PH24976A - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number: PH24976A
Authority: PH; Philippines
Prior art keywords: alkyl; compounds; disclosed; indole derivatives; headache
Prior art date: 1987-08-13

Application number

PH37409A

Other languages

English (en)

Inventor

Alexander William Oxford

Martin Richard Owen

Darki Butina

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-13

Filing date

1988-08-12

Publication date

1990-12-26

1987-08-13 Priority claimed from GB878719167A external-priority patent/GB8719167D0/en

1988-06-14 Priority claimed from GB888814002A external-priority patent/GB8814002D0/en

1988-06-17 Priority claimed from GB888814481A external-priority patent/GB8814481D0/en

1988-08-12 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1990-12-26 Publication of PH24976A publication Critical patent/PH24976A/en

Links

229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
206010009094 Chronic paroxysmal hemicrania Diseases 0.000 abstract 1
208000006561 Cluster Headache Diseases 0.000 abstract 1
206010019233 Headaches Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000018912 cluster headache syndrome Diseases 0.000 abstract 1
231100000869 headache Toxicity 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
208000007777 paroxysmal Hemicrania Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
208000019553 vascular disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PH37409A 1987-08-13 1988-08-12 Indole derivatives PH24976A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB878719167A GB8719167D0 (en)	1987-08-13	1987-08-13	Chemical compounds
GB888814002A GB8814002D0 (en)	1988-06-14	1988-06-14	Chemical compounds
GB888814481A GB8814481D0 (en)	1988-06-17	1988-06-17	Chemical compounds

Publications (1)

Publication Number	Publication Date
PH24976A true PH24976A (en)	1990-12-26

Family

ID=27263551

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH37409A PH24976A (en)	1987-08-13	1988-08-12	Indole derivatives

Country Status (28)

Country	Link
US (1)	US4997841A (da)
EP (1)	EP0303507B1 (da)
JP (1)	JPH0633252B2 (da)
KR (1)	KR0131327B1 (da)
AT (1)	ATE92057T1 (da)
AU (1)	AU611469B2 (da)
CA (1)	CA1310968C (da)
CY (1)	CY1728A (da)
CZ (1)	CZ404291A3 (da)
DE (2)	DE3882614T2 (da)
DK (1)	DK172696B1 (da)
ES (1)	ES2058292T3 (da)
FI (1)	FI92397C (da)
GB (1)	GB2208646B (da)
HK (1)	HK86793A (da)
HU (1)	HU211576A9 (da)
IE (1)	IE61488B1 (da)
IL (1)	IL87437A0 (da)
LU (1)	LU90160I2 (da)
LV (1)	LV5736B4 (da)
NL (1)	NL970035I2 (da)
NO (2)	NO174052C (da)
NZ (1)	NZ225820A (da)
PH (1)	PH24976A (da)
PT (1)	PT88255B (da)
SG (1)	SG65393G (da)
SK (1)	SK281495B6 (da)
UY (1)	UY23657A1 (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
GB8903036D0 (en) *	1989-02-10	1989-03-30	Glaxo Group Ltd	Chemical compounds
CZ288351B6 (en) *	1990-06-07	2001-05-16	Astrazeneca Ab	Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
DK152090D0 (da) *	1990-06-22	1990-06-22	Lundbaek A S H	Piperidylsubstituerede indolderivater
US5643784A (en) *	1990-12-04	1997-07-01	H, Lundbeck A/S	Indan derivatives
NZ243065A (en)	1991-06-13	1995-07-26	Lundbeck & Co As H	Piperidine derivatives and pharmaceutical compositions
TW222631B (da) *	1991-07-15	1994-04-21	Duphar Int Res
GB9209882D0 (en) *	1992-05-07	1992-06-24	Glaxo Lab Sa	Compositions
GB9211277D0 (en)	1992-05-28	1992-07-15	Glaxo Group Inc	Pharmaceutical compositions
AU675964B2 (en) *	1992-08-05	1997-02-27	John Wyeth & Brother Limited	Amide derivatives
GB9320115D0 (en) *	1993-09-29	1993-11-17	Glaxo Group Ltd	Process
US5521196A (en) *	1994-10-05	1996-05-28	Eli Lilly And Company	5-HT1F agonists for the treatment of migraine
US5521197A (en) *	1994-12-01	1996-05-28	Eli Lilly And Company	3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
FR2731222A1 (fr) *	1995-03-02	1996-09-06	Pf Medicament	Nouveaux derives de piperazine aminoindoles cycliques, leur procede de preparation et leur utilisation a titre de medicaments
FR2731224B1 (fr) *	1995-03-02	1997-05-30	Pf Medicament	Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
KR19980703048A (ko) *	1995-03-20	1998-09-05	피터쥐.스트링거	5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
AU2104097A (en) *	1996-03-13	1997-10-01	Glaxo Group Limited	Medicaments comprising 5ht1-like receptor agonists with an increased absorption
AR013669A1 (es) *	1997-10-07	2001-01-10	Smithkline Beecham Corp	Compuestos y metodos
US6066092A (en) *	1997-11-06	2000-05-23	Cady; Roger K.	Preemptive prophylaxis of migraine device and method
US7189753B1 (en)	1997-11-06	2007-03-13	Cady Roger K	Preemptive prophylaxis of migraine
MXPA02012927A (es) *	2000-07-21	2003-05-15	Lundbeck & Co As H	Derivados de indol utiles para el tratamiento de padecimientos del sistema nervioso central.
WO2002044159A2 (en) *	2000-11-29	2002-06-06	Eli Lilly And Company	1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence
US8329734B2 (en)	2009-07-27	2012-12-11	Afgin Pharma Llc	Topical therapy for migraine
EP2316468A1 (en)	2002-02-22	2011-05-04	Shire LLC	Delivery system and methods for protecting and administering dextroamphetamine
EP1644004A4 (en)	2003-06-20	2010-10-06	Ronald Aung-Din	LOCAL THERAPY FOR THE TREATMENT OF MIGRAINS, MUSCLE CLARIFICATIONS, MUSCLE SPASMS, SPASTICITY AND RELATED CONDITIONS
PL1814538T3 (pl) *	2004-11-24	2010-02-26	Alcon Inc	Sposób dostarczania donosowego sprayu
WO2008049116A2 (en) *	2006-10-19	2008-04-24	Auspex Pharmaceuticals, Inc.	Substituted indoles
WO2008056378A2 (en) *	2006-11-09	2008-05-15	Natco Pharma Limited	Novel process for the preparation of naratriptan hydrochloride
WO2008072257A2 (en) *	2006-12-12	2008-06-19	Ind-Swift Laboratories Limited	Process for the preparation of indole derivatives
WO2009016466A2 (en) *	2007-07-30	2009-02-05	Orchid Chemicals & Pharmaceuticals Limited	A process for the preparation of naratriptan hydrochloride
WO2009118753A2 (en) *	2008-03-07	2009-10-01	Usv Limited	Process for preparation of naratriptan hydrochloride
CA2729346A1 (en)	2008-06-30	2010-01-14	Afgin Pharma, Llc	Topical regional neuro-affective therapy
WO2010004580A2 (en) *	2008-07-11	2010-01-14	Ind-Swift Laboratories Limited	Process for preparing indole derivatives
WO2010084507A2 (en) *	2008-07-15	2010-07-29	Sun Pharmaceutical Industries Ltd.	Process for the preparation of n-methyl-2-[3-(1-methyl-4-piperidyl)-1h-indol-5-yl]-ethanesulfonamide and its acid addition salts
US8735589B2 (en)	2009-08-20	2014-05-27	Cipla Limited	Process for the synthesis of naratriptan
CN102276581B (zh) *	2011-08-05	2013-06-12	上海师范大学	N-取代四氢吡啶连吲哚类化合物及其制备方法及应用
US10383816B2 (en)	2015-03-02	2019-08-20	Afgin Pharma, Llc	Topical regional neuro-affective therapy with cannabinoid combination products
BR112017018944A2 (en)	2015-03-02	2018-05-15	Afgin Pharma, Llc	method of treating a disease state or condition in humans with a carbinoid drug, and method of treating a disease state or condition in a mammal other than a human with carbinoid drug (s)
US20180049994A1 (en)	2016-08-16	2018-02-22	Afgin Pharma, Llc	Topical regional neuro-affective therapy with caryophyllene
EP3766483A1 (en)	2019-07-19	2021-01-20	BioPharma Synergies, S. L.	Orodispersible powder composition comprising a triptan

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2362628A1 (fr) *	1976-08-26	1978-03-24	Roussel Uclaf	Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) *	1978-01-16	1979-11-02	Roussel Uclaf	Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
GR79215B (da) *	1982-06-07	1984-10-22	Glaxo Group Ltd
FR2533924A1 (fr) *	1982-10-05	1984-04-06	Roussel Uclaf	Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
GB8332437D0 (en) *	1983-12-06	1984-01-11	Glaxo Group Ltd	Chemical compounds
GB8332435D0 (en) *	1983-12-06	1984-01-11	Glaxo Group Ltd	Chemical compounds
DE3419935A1 (de) *	1984-05-28	1985-11-28	Merck Patent Gmbh, 6100 Darmstadt	Verwendung von hydroxyindolderivaten bei der senkung des blutdrucks
GB2162522B (en) *	1984-08-01	1988-02-24	Glaxo Group Ltd	An indole derivative
US4548939A (en) *	1984-10-01	1985-10-22	Janssen Pharmaceutica N. V.	1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4785016A (en) *	1984-12-04	1988-11-15	Glaxo Group Limited	Indole derivatives
IE58370B1 (en) *	1985-04-10	1993-09-08	Lundbeck & Co As H	Indole derivatives
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
GB8903036D0 (en) *	1989-02-10	1989-03-30	Glaxo Group Ltd	Chemical compounds

1988
- 1988-08-12 PH PH37409A patent/PH24976A/en unknown
- 1988-08-12 ES ES88307499T patent/ES2058292T3/es not_active Expired - Lifetime
- 1988-08-12 JP JP63201839A patent/JPH0633252B2/ja not_active Expired - Lifetime
- 1988-08-12 IE IE247788A patent/IE61488B1/en not_active IP Right Cessation
- 1988-08-12 IL IL87437A patent/IL87437A0/xx not_active IP Right Cessation
- 1988-08-12 US US07/231,274 patent/US4997841A/en not_active Expired - Lifetime
- 1988-08-12 KR KR88010367A patent/KR0131327B1/ko not_active Expired - Lifetime
- 1988-08-12 EP EP88307499A patent/EP0303507B1/en not_active Expired - Lifetime
- 1988-08-12 FI FI883744A patent/FI92397C/fi not_active IP Right Cessation
- 1988-08-12 NZ NZ225820A patent/NZ225820A/xx unknown
- 1988-08-12 DE DE88307499T patent/DE3882614T2/de not_active Expired - Lifetime
- 1988-08-12 NO NO883587A patent/NO174052C/no not_active IP Right Cessation
- 1988-08-12 AT AT88307499T patent/ATE92057T1/de active
- 1988-08-12 AU AU20692/88A patent/AU611469B2/en not_active Expired
- 1988-08-12 GB GB8819200A patent/GB2208646B/en not_active Expired - Lifetime
- 1988-08-12 DK DK198804554A patent/DK172696B1/da not_active IP Right Cessation
- 1988-08-12 CA CA000574643A patent/CA1310968C/en not_active Expired - Lifetime
- 1988-08-12 PT PT88255A patent/PT88255B/pt not_active IP Right Cessation
- 1988-08-13 SK SK4042-91A patent/SK281495B6/sk unknown
1991
- 1991-12-23 CZ CS914042A patent/CZ404291A3/cs unknown
1993
- 1993-05-19 SG SG653/93A patent/SG65393G/en unknown
- 1993-08-19 HK HK867/93A patent/HK86793A/xx not_active IP Right Cessation
- 1993-09-23 UY UY23657A patent/UY23657A1/es not_active IP Right Cessation
1994
- 1994-05-06 CY CY172894A patent/CY1728A/en unknown
1995
- 1995-06-30 HU HU95P/P00631P patent/HU211576A9/hu unknown
- 1995-12-14 LV LV950371A patent/LV5736B4/xx unknown
1997
- 1997-09-10 NL NL970035C patent/NL970035I2/nl unknown
- 1997-10-31 LU LU90160C patent/LU90160I2/fr unknown
1998
- 1998-02-05 NO NO1998008C patent/NO1998008I1/no unknown
- 1998-08-12 DE DE19983883614 patent/DE19775082I2/de active Active

Also Published As

Publication number	Publication date
CY1728A (en)	1994-05-06
CZ404291A3 (en)	1993-04-14
LV5736B4 (lv)	1997-06-20
SK404291A3 (en)	2000-09-12
JPH0633252B2 (ja)	1994-05-02
AU2069288A (en)	1989-02-16
KR890003731A (ko)	1989-04-17
PT88255A (pt)	1989-06-30
IE882477L (en)	1989-02-13
DE3882614D1 (de)	1993-09-02
GB2208646A (en)	1989-04-12
DK455488A (da)	1989-02-14
DK172696B1 (da)	1999-05-31
NO174052B (no)	1993-11-29
NO883587D0 (no)	1988-08-12
EP0303507A3 (en)	1990-09-19
DE3882614T2 (de)	1993-11-18
KR0131327B1 (en)	1998-04-17
LV5736A4 (lv)	1996-06-20
GB2208646B (en)	1991-06-26
CA1310968C (en)	1992-12-01
FI92397C (fi)	1994-11-10
EP0303507A2 (en)	1989-02-15
FI92397B (fi)	1994-07-29
HK86793A (en)	1993-08-27
NO1998008I1 (no)	1998-02-05
NO174052C (no)	1994-03-09
PT88255B (pt)	1995-03-01
IL87437A0 (en)	1989-01-31
DK455488D0 (da)	1988-08-12
LU90160I2 (fr)	1998-01-14
ES2058292T3 (es)	1994-11-01
US4997841A (en)	1991-03-05
FI883744L (fi)	1989-02-14
SK281495B6 (sk)	2001-04-09
NL970035I2 (nl)	1998-01-05
FI883744A0 (fi)	1988-08-12
NZ225820A (en)	1990-09-26
GB8819200D0 (en)	1988-09-14
AU611469B2 (en)	1991-06-13
ATE92057T1 (de)	1993-08-15
UY23657A1 (es)	1994-02-25
EP0303507B1 (en)	1993-07-28
JPH01207288A (ja)	1989-08-21
IE61488B1 (en)	1994-11-02
NL970035I1 (nl)	1997-11-03
HU211576A9 (en)	1995-12-28
DE19775082I2 (de)	2006-04-27
NO883587L (no)	1989-02-14
SG65393G (en)	1993-08-06

Publication	Publication Date	Title
KR0131327B1 (en)	1998-04-17	Indole derivatives
DK391289A (da)	1990-02-11	Indolderivater
PL309874A1 (en)	1996-02-05	Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
ZA90974B (en)	1991-10-30	Indole derivatives
MY103509A (en)	1993-06-30	Indole derivatives.
CS548987A2 (en)	1988-09-16	Process for preparing new tetracycline derivatives of indole