CY1733A - Leukotriene antagonists - Google Patents

Leukotriene antagonists

Info

Publication number: CY1733A
Authority: CY; Cyprus
Prior art keywords: leukotriene antagonists; co2r10; intermediates; fluoro; methoxy
Prior art date: 1985-04-19

Application number

CY173394A

Other languages

English (en)

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-19

Filing date

1994-05-06

Publication date

1994-05-06

1994-05-06 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1994-05-06 Publication of CY1733A publication Critical patent/CY1733A/xx

Links

239000003199 leukotriene receptor blocking agent Substances 0.000 title abstract 2
125000004185 ester group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
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- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
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- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
- C—CHEMISTRY; METALLURGY
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- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/542—Alkylated benzaldehydes
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- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/546—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings polycyclic
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- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
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- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- C—CHEMISTRY; METALLURGY
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Epoxy Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Cosmetics (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

CY173394A 1985-04-19 1994-05-06 Leukotriene antagonists CY1733A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US72526485A	1985-04-19	1985-04-19

Publications (1)

Publication Number	Publication Date
CY1733A true CY1733A (en)	1994-05-06

Family

ID=24913819

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY173394A CY1733A (en)	1985-04-19	1994-05-06	Leukotriene antagonists

Country Status (23)

Country	Link
EP (2)	EP0358240B1 (da)
JP (3)	JPS61249958A (da)
KR (1)	KR950003335B1 (da)
CN (2)	CN1008091B (da)
AT (2)	ATE53991T1 (da)
AU (3)	AU595193B2 (da)
CA (2)	CA1276937C (da)
CY (1)	CY1733A (da)
DE (2)	DE3688561T2 (da)
DK (1)	DK176586A (da)
EG (1)	EG18226A (da)
ES (1)	ES8801175A1 (da)
FI (1)	FI88293C (da)
GR (1)	GR860993B (da)
HK (1)	HK106893A (da)
HU (2)	HU196365B (da)
IE (1)	IE58958B1 (da)
IL (1)	IL78495A (da)
MY (1)	MY102219A (da)
NO (1)	NO164414C (da)
PH (1)	PH23745A (da)
PT (1)	PT82394B (da)
ZA (1)	ZA862794B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5143931A (en) *	1982-06-24	1992-09-01	Smithkline Beecham Corporation	Leukotriene antagonists containing tetrazolyl groups
EP0358240B1 (en)	1985-04-19	1993-06-09	Smithkline Beecham Corporation	Intermediates for the preparation of leukotriene antagonists
US4937253A (en) *	1985-04-19	1990-06-26	Smithkline Beecham Corporation	Ester prodrugs
US5314918A (en) *	1987-06-24	1994-05-24	Smithkline Beecham Corporation	Leukotriene antagonists
CA1334200C (en) *	1987-06-24	1995-01-31	James Simpson Frazee	Leukotriene antagonists
US4954513A (en) *	1988-12-23	1990-09-04	Smithkline Beecham Corporation	Leukotriene antagonists
US5110959A (en) *	1989-06-14	1992-05-05	Smithkline Beckman Corp.	Process for preparation of epoxy esters and intermediates prepared thereby
PT94376A (pt) *	1989-06-14	1991-03-20	Smithkline Beecham Corp	Processo de preparacao de derivados de feniloxirano, intermediarios na preparacao de acidos 2-hidroxi-3-(tio substituido)-3-(fenil substituido)carboxilicos, de amidas e esteres
DE69123428T2 (de) *	1990-04-26	1997-05-15	Senju Pharma Co	Inhibitor von lebererkrankungen
CA2081480A1 (en) *	1990-05-01	1991-11-02	James S. Frazee	3-naphthyl-3-carboxyalkylthio or oxy substituted alkanoic acid leukotriene antagonists
EP0528957A4 (en) *	1990-05-01	1993-05-05	Smith-Kline Beecham Corporation	Five-membered ring alkanoic acid leukotriene antagonists
NZ239200A (en) *	1990-08-01	1994-08-26	Smithkline Beecham Corp	Process and intermediates for the preparation of 2-hydroxy-3-sulphido-3-phenyl propanoic acids
DE102005051788B3 (de)	2005-10-28	2007-05-16	Novelis Deutschland Gmbh	Verfahren und Vorrichtung zur Herstellung eines Wickelrohres
CN120789343B (zh) *	2025-09-15	2025-12-16	杭州之江有机硅化工有限公司	一种抗菌水凝胶及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1577550A (en) *	1976-10-18	1980-10-22	Sagami Chem Res	-thio-alkanoic acid derivatives
FR2468362A1 (fr) *	1978-07-12	1981-05-08	Oreal	Compositions cosmetiques a base de dithioethers pour le traitement de l'etat gras des cheveux et de la peau, nouveaux composes et leur procede d'obtention
DE3068213D1 (en) *	1979-09-05	1984-07-19	Glaxo Group Ltd	Phenol derivatives, processes for their preparation and pharmaceutical compositions containing them
US4513005A (en) *	1981-06-18	1985-04-23	Lilly Industries Limited	SRS-A antagonists
DE3360677D1 (en) *	1982-11-11	1985-10-03	Beecham Group Plc	Arachidonic acid analogues, processes for their preparation and their use in medicine
GB8320943D0 (en) *	1983-08-03	1983-09-07	Lilly Industries Ltd	Organic compounds
NO160576C (no) *	1984-01-19	1989-05-03	Smithkline Beckman Corp	Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive karboksylsyrederivater.
EP0161172A1 (fr) *	1984-04-19	1985-11-13	Synthelabo	Dérivés d'acide n-(phenylmethylthio-3 oxo-1 propyl)-aminoacétique, leur préparation et leur application en thérapeutique
EP0358240B1 (en)	1985-04-19	1993-06-09	Smithkline Beecham Corporation	Intermediates for the preparation of leukotriene antagonists

1986
- 1986-04-14 EP EP89118801A patent/EP0358240B1/en not_active Expired - Lifetime
- 1986-04-14 EP EP86302752A patent/EP0202759B1/en not_active Expired - Lifetime
- 1986-04-14 AU AU56050/86A patent/AU595193B2/en not_active Expired
- 1986-04-14 AT AT86302752T patent/ATE53991T1/de not_active IP Right Cessation
- 1986-04-14 AT AT89118801T patent/ATE90330T1/de not_active IP Right Cessation
- 1986-04-14 DE DE8989118801T patent/DE3688561T2/de not_active Expired - Fee Related
- 1986-04-14 CA CA000506607A patent/CA1276937C/en not_active Expired - Lifetime
- 1986-04-14 DE DE8686302752T patent/DE3672130D1/de not_active Expired - Lifetime
- 1986-04-15 IL IL78495A patent/IL78495A/xx not_active IP Right Cessation
- 1986-04-15 PT PT82394A patent/PT82394B/pt unknown
- 1986-04-15 ZA ZA862794A patent/ZA862794B/xx unknown
- 1986-04-15 GR GR860993A patent/GR860993B/el unknown
- 1986-04-17 FI FI861635A patent/FI88293C/fi not_active IP Right Cessation
- 1986-04-17 HU HU861607A patent/HU196365B/hu unknown
- 1986-04-17 DK DK176586A patent/DK176586A/da not_active Application Discontinuation
- 1986-04-17 EG EG217/86A patent/EG18226A/xx active
- 1986-04-17 HU HU883764A patent/HU198918B/hu not_active IP Right Cessation
- 1986-04-18 JP JP61091151A patent/JPS61249958A/ja active Granted
- 1986-04-18 NO NO861534A patent/NO164414C/no unknown
- 1986-04-18 PH PH33678A patent/PH23745A/en unknown
- 1986-04-18 KR KR1019860002994A patent/KR950003335B1/ko not_active Expired - Fee Related
- 1986-04-18 CN CN86102482A patent/CN1008091B/zh not_active Expired
- 1986-04-18 IE IE102586A patent/IE58958B1/en not_active IP Right Cessation
- 1986-04-18 ES ES554135A patent/ES8801175A1/es not_active Expired
1987
- 1987-09-30 MY MYPI87002366A patent/MY102219A/en unknown
- 1987-10-01 AU AU79291/87A patent/AU604060B2/en not_active Ceased
1989
- 1989-08-31 CA CA000610102A patent/CA1314899C/en not_active Expired - Fee Related
- 1989-10-10 CN CN89107865A patent/CN1025564C/zh not_active Expired - Fee Related
1990
- 1990-06-26 AU AU57897/90A patent/AU5789790A/en not_active Abandoned
1992
- 1992-06-03 JP JP4142513A patent/JPH0643358B2/ja not_active Expired - Lifetime
- 1992-06-03 JP JP4142503A patent/JPH0692380B2/ja not_active Expired - Lifetime
1993
- 1993-10-07 HK HK1068/93A patent/HK106893A/en not_active IP Right Cessation
1994
- 1994-05-06 CY CY173394A patent/CY1733A/xx unknown

Also Published As

Publication number	Publication date
FI861635A0 (fi)	1986-04-17
DE3688561T2 (de)	1993-09-23
ZA862794B (en)	1987-06-24
KR860008131A (ko)	1986-11-12
CA1314899C (en)	1993-03-23
KR950003335B1 (ko)	1995-04-10
EP0358240A3 (en)	1990-06-20
AU5605086A (en)	1986-10-23
EP0358240A2 (en)	1990-03-14
ATE90330T1 (de)	1993-06-15
EP0202759A2 (en)	1986-11-26
AU604060B2 (en)	1990-12-06
IE861025L (en)	1986-10-19
PH23745A (en)	1989-11-03
IL78495A0 (en)	1986-08-31
EP0202759A3 (en)	1988-09-07
DE3688561D1 (de)	1993-07-15
NO164414B (no)	1990-06-25
MY102219A (en)	1992-05-15
JPH05194460A (ja)	1993-08-03
EP0202759B1 (en)	1990-06-20
ES554135A0 (es)	1987-12-16
PT82394B (pt)	1988-08-17
JPH0643358B2 (ja)	1994-06-08
CA1276937C (en)	1990-11-27
HK1006838A1 (en)	1999-03-19
IE58958B1 (en)	1993-12-01
NO164414C (no)	1990-10-03
AU595193B2 (en)	1990-03-29
CN1025564C (zh)	1994-08-03
HU198918B (en)	1989-12-28
DK176586D0 (da)	1986-04-17
DK176586A (da)	1986-10-20
IL78495A (en)	1993-01-14
HU196365B (en)	1988-11-28
EG18226A (en)	1992-10-30
EP0358240B1 (en)	1993-06-09
HUT43812A (en)	1987-12-28
PT82394A (en)	1986-05-01
JPH0692380B2 (ja)	1994-11-16
GR860993B (en)	1986-08-12
CN86102482A (zh)	1987-02-04
CN1008091B (zh)	1990-05-23
AU7929187A (en)	1988-03-17
JPS61249958A (ja)	1986-11-07
JPH0474348B2 (da)	1992-11-26
DE3672130D1 (de)	1990-07-26
AU5789790A (en)	1990-12-13
HK106893A (en)	1993-10-15
NO861534L (no)	1986-10-20
CN1040586A (zh)	1990-03-21
ATE53991T1 (de)	1990-07-15
FI88293C (fi)	1993-04-26
FI88293B (fi)	1993-01-15
ES8801175A1 (es)	1987-12-16
FI861635A7 (fi)	1986-10-20
JPH05194302A (ja)	1993-08-03

Publication	Publication Date	Title
PT82394A (en)	1986-05-01	Leukotriene antagonists
GB8611396D0 (en)	1986-06-18	Determination of thermophysical properties
GB8627583D0 (en)	1986-12-17	Measurement of thermal conditions
GB2170317B (en)	1988-08-03	Measuring the thermal conductivity of gases
EP0199210A3 (en)	1988-12-21	Conversion of 1,3-dioxanes into 4-oxa-aldehydes
AU589120B2 (en)	1989-10-05	Multiply-tritiated steroidal-20,17-spirolactones and their use as tracer compounds
GB8520202D0 (en)	1985-09-18	Gas turbine aero-engine
GB8515613D0 (en)	1985-07-24	Constant temperature probe
DE3663868D1 (en)	1989-07-13	Transformer comprising an air gap
KR870007064U (ko)	1987-05-11	가스 연소기용 취사용기 받침구
GB8609125D0 (en)	1986-05-21	Determination of nitrite
SU1259554A1 (ru)	1996-04-20	Шарнир универсального шпинделя
GB2186961B (en)	1989-10-11	Gas burner
GB8527865D0 (en)	1985-12-18	Graphite probe & electrothermal atomiser
GB8530850D0 (en)	1986-01-22	Measuring minor ingredient of gas
SU1269465A1 (ru)	1996-04-10	Способ получения 2-анилино-7-гидрокси-6н-1,3,4-тиадиазепинов
EP0076017A3 (en)	1984-03-28	Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor
BG39597A1 (en)	1986-07-15	Whirling head of gas burner
GB8510335D0 (en)	1985-05-30	Co-generation of energy & carbon dioxide
LV10498A (lv)	1995-02-20	Plazmidas iegusanas panemiens mikroorganisms
IL74814A0 (en)	1985-07-31	Detector for determination of combustible gases
PL255138A1 (en)	1987-03-23	Personal methane detector
ZA817866B (en)	1982-10-27	Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor
GB8523895D0 (en)	1985-10-30	Tapping & dieing attachments