CY2009006I2 - ΑΜΙΔΙΑ δ-AMINO-γ-ΥΔΡΟΞΥ-ω-ΑΡΥΛΟ-ΑΛΚΑΝΙΚΟΥ ΟΞΕΟΣ ΜΕ ΙΔΙΟΤΗΤΕΣ ΑΝΑΣΤΟΛΗΣ ΕΝΖΥΜΩΝ, ΙΔΙΑΙΤΕΡΑ ΤΗΣ ΡΕΝΙΝΗΣ - Google Patents

ΑΜΙΔΙΑ δ-AMINO-γ-ΥΔΡΟΞΥ-ω-ΑΡΥΛΟ-ΑΛΚΑΝΙΚΟΥ ΟΞΕΟΣ ΜΕ ΙΔΙΟΤΗΤΕΣ ΑΝΑΣΤΟΛΗΣ ΕΝΖΥΜΩΝ, ΙΔΙΑΙΤΕΡΑ ΤΗΣ ΡΕΝΙΝΗΣ

Info

Publication number
CY2009006I2
CY2009006I2 CY2009006C CY2009006C CY2009006I2 CY 2009006 I2 CY2009006 I2 CY 2009006I2 CY 2009006 C CY2009006 C CY 2009006C CY 2009006 C CY2009006 C CY 2009006C CY 2009006 I2 CY2009006 I2 CY 2009006I2
Authority
CY
Cyprus
Prior art keywords
renin
aryl
hydroxy
amino
acid amides
Prior art date
Application number
CY2009006C
Other languages
English (en)
Other versions
CY2009006I1 (el
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4204102&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2009006(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY2009006I1 publication Critical patent/CY2009006I1/el
Publication of CY2009006I2 publication Critical patent/CY2009006I2/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
CY2009006C 1994-04-18 2009-05-11 ΑΜΙΔΙΑ δ-AMINO-γ-ΥΔΡΟΞΥ-ω-ΑΡΥΛΟ-ΑΛΚΑΝΙΚΟΥ ΟΞΕΟΣ ΜΕ ΙΔΙΟΤΗΤΕΣ ΑΝΑΣΤΟΛΗΣ ΕΝΖΥΜΩΝ, ΙΔΙΑΙΤΕΡΑ ΤΗΣ ΡΕΝΙΝΗΣ CY2009006I2 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH116994 1994-04-18

Publications (2)

Publication Number Publication Date
CY2009006I1 CY2009006I1 (el) 2010-07-28
CY2009006I2 true CY2009006I2 (el) 2010-07-28

Family

ID=4204102

Family Applications (4)

Application Number Title Priority Date Filing Date
CY0000064A CY2208B1 (en) 1994-04-18 2000-12-01 Delta-amino-gamma-hydroxy-omega-aryl alkanoic acidamides with enzyme especially renin inhibiting ac tivities
CY200700027C CY2007027I2 (el) 1994-04-18 2007-10-31 ΑΜΙΔΙΑ δ-ΑΜΙΝΟ-γ-ΥΔΡΟΞΥ-ω-ΑΡΥΛΟ-ΑΛΚΑΝΙΚΟΥ ΟΞΕΟΣ ΜΕ ΙΔΙΟΤΗΤΕΣ ΑΝΑΣΤΟΛΗΣ ΕΝΖΥΜΩΝ, ΙΔΙΑΙΤΕΡΑ ΤΗΣ ΡΕΝΙΝΗΣ
CY2009006C CY2009006I2 (el) 1994-04-18 2009-05-11 ΑΜΙΔΙΑ δ-AMINO-γ-ΥΔΡΟΞΥ-ω-ΑΡΥΛΟ-ΑΛΚΑΝΙΚΟΥ ΟΞΕΟΣ ΜΕ ΙΔΙΟΤΗΤΕΣ ΑΝΑΣΤΟΛΗΣ ΕΝΖΥΜΩΝ, ΙΔΙΑΙΤΕΡΑ ΤΗΣ ΡΕΝΙΝΗΣ
CY2011015C CY2011015I1 (el) 1994-04-18 2011-09-27 ΑΜΙΔΙΑ δ-AMINO-γ-ΥΔΡΟΞΥ-ω-ΑΡΥΛΟ-ΑΛΚΑΝΙΚΟΥ ΟΞΕΟΣ ΜΕ ΙΔΙΟΤΗΤΕΣ ΑΝΑΣΤΟΛΗΣ ΕΝΖΥΜΩΝ, ΙΔΙΑΙΤΕΡΑ ΤΗΣ ΡΕΝΙΝΗΣ

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY0000064A CY2208B1 (en) 1994-04-18 2000-12-01 Delta-amino-gamma-hydroxy-omega-aryl alkanoic acidamides with enzyme especially renin inhibiting ac tivities
CY200700027C CY2007027I2 (el) 1994-04-18 2007-10-31 ΑΜΙΔΙΑ δ-ΑΜΙΝΟ-γ-ΥΔΡΟΞΥ-ω-ΑΡΥΛΟ-ΑΛΚΑΝΙΚΟΥ ΟΞΕΟΣ ΜΕ ΙΔΙΟΤΗΤΕΣ ΑΝΑΣΤΟΛΗΣ ΕΝΖΥΜΩΝ, ΙΔΙΑΙΤΕΡΑ ΤΗΣ ΡΕΝΙΝΗΣ

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2011015C CY2011015I1 (el) 1994-04-18 2011-09-27 ΑΜΙΔΙΑ δ-AMINO-γ-ΥΔΡΟΞΥ-ω-ΑΡΥΛΟ-ΑΛΚΑΝΙΚΟΥ ΟΞΕΟΣ ΜΕ ΙΔΙΟΤΗΤΕΣ ΑΝΑΣΤΟΛΗΣ ΕΝΖΥΜΩΝ, ΙΔΙΑΙΤΕΡΑ ΤΗΣ ΡΕΝΙΝΗΣ

Country Status (26)

Country Link
US (5) US5559111A (el)
EP (1) EP0678503B1 (el)
JP (1) JP3240322B2 (el)
KR (1) KR100353779B1 (el)
CN (2) CN1153759C (el)
AT (1) ATE183997T1 (el)
AU (1) AU699616B2 (el)
BR (1) BR1100656A (el)
CA (1) CA2147056C (el)
CY (4) CY2208B1 (el)
CZ (1) CZ287935B6 (el)
DE (4) DE122007000071I2 (el)
DK (1) DK0678503T3 (el)
ES (1) ES2137478T3 (el)
FI (1) FI118336B (el)
GR (1) GR3031997T3 (el)
HU (2) HUT71701A (el)
IL (1) IL113403A (el)
LU (2) LU91373I2 (el)
MY (1) MY119161A (el)
NL (2) NL300296I2 (el)
NO (4) NO310410B1 (el)
NZ (1) NZ270936A (el)
RU (1) RU95105970A (el)
TW (2) TW366341B (el)
ZA (3) ZA953050B (el)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
EP0716077A1 (de) * 1994-12-08 1996-06-12 Ciba-Geigy Ag Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
WO1999031074A2 (en) * 1997-12-16 1999-06-24 Warner-Lambert Company ((cyclo)alkyl substituted)-.gamma.-aminobutyric acid derivatives (=gaba analogues), their preparation and their use in the treatment of neurological disorders
US6846799B1 (en) 1998-08-18 2005-01-25 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
US7354894B2 (en) * 1998-08-18 2008-04-08 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
US6833460B2 (en) * 1999-06-18 2004-12-21 E. I. Du Pont De Nemours And Company Preparation and use of gamma-butyrolactones as cross-linking agents
US6423850B1 (en) 1999-06-18 2002-07-23 E.I. Du Pont De Nemours And Company Preparation and use of gamma-butyrolactones as cross-linking agents
US6777574B1 (en) * 1999-07-29 2004-08-17 Speedel Pharma Ag 2-alkyl-5-halogen-pent-4-ene carboxylic acids and their production
US6881868B2 (en) * 2000-07-03 2005-04-19 Speedel Pharma Ag Process for the preparation of (R)-2-alkyl-3-phenyl-1-propanols
US6730798B2 (en) * 2000-07-05 2004-05-04 Speedel Pharma Ag Process for the preparation of substituted octanoyl amides
AU2001273764A1 (en) * 2000-07-25 2002-02-05 Speedel Pharma Ag Process for the preparation of substituted octanoyl amides
US8168616B1 (en) * 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
ATE342887T1 (de) 2000-12-14 2006-11-15 Speedel Pharma Ag Verfahren zur herstellung von aryloctanoyl-amiden
JP3440082B2 (ja) 2001-02-19 2003-08-25 科学技術振興事業団 電気自動車用インホイールモーター
PT1412514E (pt) 2001-05-15 2010-04-27 Novartis Ag Processo enzimático para a preparação de ésteres carboxílicos substituídos
JP2004535424A (ja) * 2001-06-11 2004-11-25 イーラン　ファーマスーティカルズ、インコーポレイテッド アルツハイマー病の治療に有用な置換アミノアルコール
CN1571668A (zh) * 2001-10-18 2005-01-26 诺瓦提斯公司 At1－受体拮抗剂和心血管药物形成的盐
US20050101638A1 (en) * 2002-11-08 2005-05-12 Webb Randy L. Combination of organic compounds
KR20100137026A (ko) 2002-05-17 2010-12-29 노파르티스 아게 레닌 억제제, 칼슘 채널 차단제 및 이뇨제를 포함하는 약제학적 조성물
GB0212410D0 (en) * 2002-05-29 2002-07-10 Novartis Ag Organic compounds
AU2003237546A1 (en) * 2002-06-11 2003-12-22 Elan Pharmaceuticals, Inc. METHODS OF TREATING ALZHEIMER'S DISEASE USING AROMATICALLY SUBSTITUTED Omega-AMINO-ALKANOIC ACID AMIDES AND ALKANOIC ACID DIAMIDES
US20060154926A1 (en) * 2002-06-11 2006-07-13 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
EP2573079A3 (en) * 2002-08-23 2015-03-11 Novartis AG Benzimidazole quinolinones and uses thereof
US7049469B2 (en) 2002-10-24 2006-05-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing (R)-salbutamol
PE20040762A1 (es) 2002-11-27 2004-11-06 Elan Pharm Inc Ureas substituidas y carbamatos utiles para el tratamiento de la enfermedad de alzheimer
WO2004100871A2 (en) * 2003-05-09 2004-11-25 Pharmacia Corporation Combination of an aldosterone receptor antagonist and a renin inhibitor
MXPA06002188A (es) * 2003-08-25 2006-04-27 Warner Lambert Co Nuevos compuestos antimicrobianos de ariloxazolidinona.
CA2600973C (en) * 2003-11-26 2012-08-07 Novartis Ag .delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid
GB0327839D0 (en) * 2003-12-01 2003-12-31 Novartis Ag Organic compounds
PE20050596A1 (es) * 2003-12-19 2005-10-18 Novartis Ag Microemulsion que comprende un inhibidor renina
BRPI0507030A (pt) * 2004-01-22 2007-06-05 Novartis Ag combinação de compostos orgánicos
TW200535131A (en) * 2004-01-23 2005-11-01 Speedel Experimenta Ag Organic compounds
DE602005025344D1 (de) * 2004-01-23 2011-01-27 Novartis Ag Aminoalkoholderivate und deren wirkung als renininhibitoren
MY144477A (en) 2004-03-17 2011-09-30 Novartis Ag Galenic formulations of organic compounds
US20070191487A1 (en) * 2004-03-17 2007-08-16 Rigassi-Dietrich Petra G Galenic formulations of organic compounds
RU2426532C2 (ru) 2004-03-17 2011-08-20 Новартис Аг Применение органических соединений
WO2005090304A1 (en) * 2004-03-19 2005-09-29 Speedel Experimenta Ag Organic compounds
EP1699762A1 (en) * 2004-03-19 2006-09-13 Speedel Experimenta AG 5-amino-4-hydroxy-7-(1h-indolmethyl)-8-methylnonamide derivatives as renin inhibitors for the treatment of hypertension
WO2005095876A1 (en) 2004-04-01 2005-10-13 Cucumber Limited Delivery and storage of goods
PE20060416A1 (es) * 2004-08-03 2006-06-09 Novartis Ag Composicion de inhibidores de renina e inhibidores de proteinas de efusion
GB0419361D0 (en) 2004-08-31 2004-10-06 Novartis Ag Organic compounds
RU2407523C2 (ru) 2004-10-08 2010-12-27 Новартис Аг Применение ингибиторов ренина для профилактики или лечения диастолической дисфункции или диастолической сердечной недостаточности
TW200633983A (en) * 2004-12-10 2006-10-01 Speedel Experimenta Ag 5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-nonanamides
TW200631929A (en) * 2004-12-10 2006-09-16 Speedel Experimenta Ag ω -phenyloctanamides
CA2596444A1 (en) * 2005-02-02 2006-08-10 Vitae Pharmaceuticals, Inc. 1-acylamino-2-hydroxy-3-amino-w-arylalkanes as renin inhibitors
BRPI0609158A2 (pt) * 2005-03-11 2010-02-23 Speedel Experimenta Ag alcanamidas substituìdas heterocìclicas úteis como inibidores de renina
CN101171230A (zh) * 2005-03-11 2008-04-30 斯皮德尔实验股份公司 用作肾素抑制剂的杂环取代的链烷酰胺
JP4763771B2 (ja) * 2005-03-17 2011-08-31 ビーエーエスエフ ソシエタス・ヨーロピア 光学活性３−フェニルプロピオン酸誘導体を生成する方法、およびその誘導体の後続生成物
GB0511686D0 (en) * 2005-06-08 2005-07-13 Novartis Ag Organic compounds
PT1904469E (pt) * 2005-07-11 2012-01-06 Novartis Ag Novos derivados de pirocatequina
US20070021413A1 (en) 2005-07-20 2007-01-25 Peter Herold Diamino alcohols as therapeutic compounds
CA2615048A1 (en) * 2005-07-22 2007-01-25 Merck Frosst Canada Ltd. Renin inhibitors
AR057816A1 (es) * 2005-09-17 2007-12-19 Speedel Experimenta Ag Compuestos organicos
EP1764098A1 (en) * 2005-09-17 2007-03-21 Speedel Experimenta AG Diaminoalcohols derivatives for the treatment of Alzheimer, malaria, HIV
CN101268074B (zh) 2005-09-17 2011-09-21 斯皮德尔实验股份公司 5-氨基-4-羟基-7-（咪唑并[1,2-a]吡啶-6-基甲基）-8-甲基-壬酰胺衍生物和相关用作肾素抑制剂治疗高血压的化合物
GB0519764D0 (en) * 2005-09-28 2005-11-09 Novartis Ag Organic compounds
GB0521083D0 (en) * 2005-10-17 2005-11-23 Novartis Ag Organic compounds
JP2009514809A (ja) * 2005-10-18 2009-04-09 ニコックス エス エイ レニン阻害剤のニトロ誘導体
RU2008119687A (ru) 2005-10-21 2009-11-27 Новартис АГ (CH) Комбинации органических соединений
GB2431646A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431649A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431645A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431648A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431642A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
DE102005052195A1 (de) 2005-10-28 2007-05-03 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von chiralen Octensäurederivaten
TW200804241A (en) * 2006-02-24 2008-01-16 Novartis Ag New salt
GB0605688D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic compounds
US8084485B2 (en) * 2006-03-31 2011-12-27 Vitae Pharmaceuticals, Inc. 6-(aminoalkyl)indazoles
US20100298328A1 (en) * 2006-03-31 2010-11-25 Vitae Pharmaceuticals, Inc 1-Heterocyclylamino-2-Hydroxy-3-Amino-Omega-Arylalkanes
SG170830A1 (en) * 2006-04-03 2011-05-30 Novartis Ag Renin inhibitors for the treatment of hypertension
GB0612540D0 (en) 2006-06-23 2006-08-02 Novartis Ag Galenical formulations of organic compounds
CA2656079C (en) 2006-06-23 2012-08-28 Daiichi Sankyo Company, Limited Cyclic amine compound
TW200815324A (en) * 2006-06-23 2008-04-01 Daiichi Sankyo Co Ltd Straight chain amine compound
CA2657258A1 (en) 2006-07-20 2008-01-24 Novartis Ag Amino-piperidine derivatives as cetp inhibitors
EP1911762A1 (en) 2006-10-04 2008-04-16 Speedel Experimenta AG Amino alcohols and their use as renin inhibitors
US8119841B2 (en) * 2006-11-07 2012-02-21 Novartis Ag Crystalline forms of aliskiren hemifumarate
EP2089356B1 (en) * 2006-11-09 2012-04-25 Novartis AG Salt of aliskiren with orotic acid
EP1938812A1 (en) * 2006-12-22 2008-07-02 Speedel Pharma AG Pharmaceutical composition using aliskiren and avosentan
EP1958666A1 (en) 2007-02-13 2008-08-20 Speedel Experimenta AG Heterocyclic-substituted alkanamides as therapeutic compounds
WO2008113835A1 (en) * 2007-03-21 2008-09-25 Novartis Ag Process for preparing (r or s)-5-{1-azido-3-[6-methoxy-5-(3-methoxy-propoxy)-pyridin-3-ylmethyl]-4-methyl-pentyl}-3-alkyl-dihydro-furan-2-one
EP1972335A1 (en) * 2007-03-23 2008-09-24 Krka Solid dosage forms comprising aliskiren and pharmaceutically acceptable salts thereof
NZ579792A (en) * 2007-04-03 2012-03-30 Novartis Ag Processes for preparing lactone compounds
EP2173696A1 (en) 2007-07-11 2010-04-14 DSM IP Assets B.V. Preparation of a saturated aldehyde
US20090076062A1 (en) * 2007-09-13 2009-03-19 Juergen Klaus Maibaum Organic Compounds
US20090082458A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched aliskiren
KR20100076996A (ko) 2007-09-28 2010-07-06 노파르티스 아게 알리스키렌의 생약 제형
DE102007049039A1 (de) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
PL2207775T3 (pl) 2007-11-05 2012-08-31 Novartis Ag Pochodne 4-benzyloamino-1-karboksyacylo-piperydyny jako inhibitory CETP użyteczne do leczenia chorób, takich jak hiperlipidemia lub stwardnienie tętnic
BRPI0822652A2 (pt) 2007-11-13 2015-06-23 Teva Pharmáceutica Ind Ltd Petach Tirva 49131 Fórmulas polimórficas de hemifumarato de alisquireno e processos para a sua preparação
EP2062874B1 (en) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Process and intermediates for the preparation of aliskiren
AU2008333272B2 (en) 2007-12-03 2012-03-29 Novartis Ag 1,2-disubstituted-4-benzylamino-pyrrolidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperli pidemia or arteriosclerosis
EP2075244A1 (en) 2007-12-24 2009-07-01 DSMIP Assets B.V. New route to building block for making renin inhibitors
WO2009104939A2 (ko) 2008-02-22 2009-08-27 한올제약주식회사 약제학적 제제
WO2009125981A2 (ko) 2008-04-10 2009-10-15 한올제약주식회사 약제학적 제제
CA2724746A1 (en) * 2008-05-23 2009-11-26 Teva Pharmaceuticals Industries Ltd. Aliskiren monofumarate and processes for preparation thereof
WO2009149344A2 (en) * 2008-06-06 2009-12-10 Teva Pharmaceutical Industries Ltd. Solid states of aliskiren free base
EP2143425A1 (de) 2008-07-11 2010-01-13 Ratiopharm GmbH Direktverpresste Aliskiren-Tabletten
WO2010024772A1 (en) * 2008-08-29 2010-03-04 Medivir Ab Aspartyl protease inhibitors
EP2163245A1 (en) 2008-09-10 2010-03-17 Novartis Ag Renin inhibitors for the treatment of psoriasis
SI2189442T1 (sl) 2008-11-20 2015-03-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek in intermediati za pripravo aliskirena
TWI468191B (zh) 2009-01-28 2015-01-11 Novartis Ag 有機化合物之調配物
CN102046162A (zh) 2009-02-05 2011-05-04 特瓦制药工业有限公司 阿利吉仑化合物的固态形式
EP2393489B1 (en) 2009-02-05 2014-10-08 Krka, tovarna zdravil, d.d., Novo mesto Moisture-activated granulation process
CN102348452A (zh) 2009-03-20 2012-02-08 诺瓦提斯公司 缬沙坦和阿利吉仑的固定剂量组合的盖仑制剂
US20120003308A1 (en) 2009-03-20 2012-01-05 Sonali Bose Pharmaceutical Composition Comprising Aliskiren
JP2012522746A (ja) 2009-04-01 2012-09-27 レツク・フアーマシユーテイカルズ・デー・デー 活性メチレン基のジメチル化の方法
JP5746696B2 (ja) * 2009-08-11 2015-07-08 ノバルティス アーゲー ラクトンおよびラクタムの開環
WO2011028919A2 (en) 2009-09-03 2011-03-10 Teva Pharmaceutical Industries Ltd. Solid forms of aliskiren hemifumarate and processes for preparation thereof
UA108742C2 (uk) 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
WO2011048523A1 (en) * 2009-10-21 2011-04-28 CarboDesign LLC Process for the manufacture of enantiomerically pure aryloctanoic acids as aliskiren
WO2011051853A1 (en) * 2009-10-29 2011-05-05 CarboDesign LLC Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren
US20130005730A1 (en) * 2009-11-09 2013-01-03 Piaoyang Sun Novel 1,3-oxazolidine compounds and their use as renin inhibitors
US20110113995A1 (en) * 2009-11-13 2011-05-19 Lindsay Corporation Method and apparatus for planting and irrigation
US20110137047A1 (en) * 2009-12-07 2011-06-09 CarboDesign LLC Process for enantiomerically pure 8-Aryloctanoic acids as Aliskiren
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
CN101774986B (zh) 2010-01-06 2012-03-28 浙江天宇药业股份有限公司 一种制备阿利克伦及其中间体的方法
CN102140068B (zh) * 2010-01-30 2015-03-11 浙江华海药业股份有限公司 阿利吉仑中间体3-氨基-2,2-二甲基丙酰胺的制备方法
WO2011098258A1 (en) * 2010-02-10 2011-08-18 Ratiopharm Gmbh Salts of aliskiren
WO2011116115A1 (en) 2010-03-16 2011-09-22 Novartis Ag Aliskiren composition comprising a medium chain fatty acid, their process of manufacturing
TR201002256A1 (tr) 2010-03-24 2011-10-21 Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� Stabil aliskiren formülasyonları
EP2382967A1 (de) 2010-04-21 2011-11-02 ratiopharm GmbH Aliskiren in Form einer festen Dispersion
EP2382969A1 (en) 2010-04-30 2011-11-02 Sanovel Ilac Sanayi ve Ticaret A.S. Multicoated Aliskiren formulations
CN102241650B (zh) * 2010-05-14 2014-05-07 浙江九洲药业股份有限公司 用于制备阿立克仑的中间体化合物及相关制备方法
IT1400961B1 (it) * 2010-06-04 2013-07-05 Chemo Iberica Sa Processo per la produzione di aliskiren
TW201202178A (en) 2010-06-04 2012-01-16 Chemo Iberica Sa Process for producing Aliskiren
IT1402925B1 (it) * 2010-12-10 2013-09-27 Chemo Iberica Sa Processo per la produzione di aliskiren
CN101913998A (zh) * 2010-07-06 2010-12-15 上海朴颐化学科技有限公司 4-溴-2-(3-甲氧基丙氧基)-苯甲醚的制备方法
WO2012034065A1 (en) 2010-09-09 2012-03-15 Teva Pharmaceutical Industries Ltd. Aliskiren intermediates and a process for analyzing the purity of aliskiren
DK2630118T3 (en) 2010-10-19 2015-02-09 Mylan Lab Ltd SYNTHESIS OF aliskiren
CN102001920B (zh) 2010-11-09 2013-05-15 常州制药厂有限公司 一种药物中间体的制备方法
CN102161627A (zh) * 2011-02-24 2011-08-24 中国药科大学 ω-(N取代-氨基烷基)辛酰胺
EP2551260A1 (en) 2011-07-28 2013-01-30 Chemo Ibérica, S.A. Chemical process for opening ring compounds
CN102942477B (zh) * 2011-08-14 2015-12-02 浙江华海药业股份有限公司 辛烯酸衍生物及其制备方法
CN102351734B (zh) * 2011-09-05 2014-02-26 浙江普洛医药科技有限公司 一种阿利克仑的制备方法
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
US8703976B2 (en) * 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
US9056816B2 (en) 2011-10-25 2015-06-16 Jubilant Life Sciences Limited Process for the preparation of aliskiren
WO2013118138A1 (en) 2011-12-13 2013-08-15 Laboratories Ltd Mylan Novel process for the preparation of renin inhibitors
CN103172533B (zh) * 2011-12-20 2016-05-04 博瑞生物医药（苏州）股份有限公司 一种阿利克仑半富马酸盐的新晶型及其制备方法和用途
CN103204834A (zh) * 2012-01-11 2013-07-17 南京欧信医药技术有限公司 阿利克伦中间体及其制备方法和应用
EP2814806B1 (en) 2012-02-17 2016-05-25 Mylan Laboratories Ltd. An improved process for the preparation of aliskiren
WO2013124868A2 (en) 2012-02-21 2013-08-29 Mylan Laboratories Limited Solid form of aliskiren intermediate
ITMI20120354A1 (it) * 2012-03-07 2013-09-08 Friulchem Spa Processo per la produzione di aliskirene
WO2013144979A1 (en) 2012-03-28 2013-10-03 Maylan Laboratories Ltd Process for the preparation of aliskiren
WO2013167715A1 (en) 2012-05-11 2013-11-14 Novartis Ag Dispensing device
WO2013171767A1 (en) 2012-05-18 2013-11-21 Mylan Laboratories Limited An improved process for the preparation of aliskiren
EP2810644A1 (en) 2013-06-06 2014-12-10 Ferrer Internacional, S.A. Oral formulation for the treatment of cardiovascular diseases
CA2914899C (en) * 2013-06-27 2022-08-30 Dpx Holdings B.V. Preparation of grignard reagents using a fluidized bed
CA3103599A1 (en) 2018-06-14 2019-12-19 Astrazeneca Uk Limited Methods for treatment of hypertension with an angiotensin ii receptor blocker pharmaceutical composition
CN112679448B (zh) * 2020-12-31 2022-08-19 苏州昊帆生物股份有限公司 N-(2-氨基乙基)吗啉的制备方法
CN115340472B (zh) * 2022-09-19 2024-05-07 合肥工业大学 一种谷氨酸衍生物及其合成方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337207A (en) * 1980-09-04 1982-06-29 Regents Of The University Of California Biologically active catecholamine derivatives
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
JPH02124884A (ja) * 1988-07-08 1990-05-14 Zhongguo Yixuekexueyuan Yaowo Yanjiusuo Ｎ―置換アミド誘導体
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities

Also Published As

Publication number Publication date
HU9501076D0 (en) 1995-06-28
RU95105970A (ru) 1997-01-10
TW402582B (en) 2000-08-21
HUT71701A (en) 1996-01-29
FI951771A7 (fi) 1995-10-19
NL300386I1 (nl) 2009-07-01
HU9501078D0 (en) 1995-06-28
CA2147056C (en) 2005-10-25
US5646143A (en) 1997-07-08
NO951441L (no) 1995-10-19
NL300296I2 (nl) 2008-02-01
MY119161A (en) 2005-04-30
NO2007011I2 (el) 2011-07-25
CY2009006I1 (el) 2010-07-28
CN1266118C (zh) 2006-07-26
IL113403A (en) 2001-07-24
NO2011020I1 (no) 2011-09-26
US5627182A (en) 1997-05-06
CN1153759C (zh) 2004-06-16
BR1100656A (pt) 2000-06-06
ZA953052B (en) 1995-10-18
FI118336B (fi) 2007-10-15
HU226860B1 (en) 2009-12-28
TW366341B (en) 1999-08-11
JP3240322B2 (ja) 2001-12-17
CY2208B1 (en) 2002-11-08
EP0678503B1 (de) 1999-09-01
NO2007011I1 (no) 2007-12-11
DE122011100052I1 (de) 2012-01-19
DE122009000020I1 (de) 2009-08-06
CA2147056A1 (en) 1995-10-19
IL113403A0 (en) 1995-07-31
NO951441D0 (no) 1995-04-12
CY2007027I1 (el) 2009-11-04
DE122007000071I2 (de) 2009-01-02
DE122007000071I1 (de) 2008-01-31
US5654445A (en) 1997-08-05
AU1642195A (en) 1995-10-26
DE59506707D1 (de) 1999-10-07
ZA953051B (en) 1995-10-18
ATE183997T1 (de) 1999-09-15
KR950032037A (ko) 1995-12-20
CN1117960A (zh) 1996-03-06
AU699616B2 (en) 1998-12-10
HUT74074A (en) 1996-10-28
CY2011015I2 (el) 2014-04-09
CY2007027I2 (el) 2009-11-04
NL300296I1 (nl) 2007-12-03
KR100353779B1 (ko) 2003-01-08
FI951771A0 (fi) 1995-04-12
GR3031997T3 (en) 2000-03-31
CZ97695A3 (en) 1995-11-15
NO310410B1 (no) 2001-07-02
NZ270936A (en) 1997-06-24
US5705658A (en) 1998-01-06
NO2009011I2 (no) 2010-11-22
US5559111A (en) 1996-09-24
ES2137478T3 (es) 1999-12-16
HK1070881A1 (en) 2005-06-30
JPH0881430A (ja) 1996-03-26
DK0678503T3 (da) 2000-03-20
CN1550491A (zh) 2004-12-01
ZA953050B (en) 1995-11-08
CY2011015I1 (el) 2014-04-09
LU91373I2 (fr) 2007-12-31
EP0678503A1 (de) 1995-10-25
NO2009011I1 (no) 2009-06-02
CZ287935B6 (cs) 2001-03-14
LU91564I2 (fr) 2009-07-06

Similar Documents

Publication Publication Date Title
CY2007027I1 (el) ΑΜΙΔΙΑ δ-AMINO-γ-ΥΔΡΟΞΥ-ω-ΑΡΥΛΟ-ΑΛΚΑΝΙΚΟΥ ΟΞΕΟΣ ΜΕ ΙΔΙΟΤΗΤΕΣ ΑΝΑΣΤΟΛΗΣ ΕΝΖΥΜΩΝ, ΙΔΙΑΙΤΕΡΑ ΤΗΣ ΡΕΝΙΝΗΣ
FI962315L (fi) Entsyymi-inhibiittorit
FI965019A7 (fi) Entsyymi-inhibiittoreita
DE69621131D1 (de) 4-substituierte-phenylboronsäuren als enzymstabilisatoren
FI954330A7 (fi) EGIII -sellulaasin puhdistus ja molekyylikloonaus
DK46793D0 (da) Enzym
DK48693D0 (da) Enzym
FI942423A7 (fi) Sakkariinijohdannisia proteolyyttisen entsyymin inhibiittoreina
FI941766A7 (fi) sPLA2:n 1H-indoli-3-etikkahappohydratsidi-inhibiittoreita
FI932521A0 (fi) Nytt endoglukanasenzym
BR9408121A (pt) Solução anti-corrosão
FI942625L (fi) Peptidisiä fosfinyylioksimetyyliketoneja interleukiini-1beta-muuttuvan entsyymin inhibiittoreina
FI955130L (fi) L-aminohappo-oksidaasi
ATA248592A (de) Amperometrische enzymelektrode
FI960425A7 (fi) Fenyylisykloheksyylikarboksyylihappoamidien käyttö
BR9510426A (pt) Produção de cefotaxima
FI954422L (fi) Ferroseenin käyttö
NO973008D0 (no) Enzymstabilisering
KR970001449A (ko) 고 니트릴 다중합체용 안정화제
TH30422B (th) เดลต้า-อะมิโน-แกมมา-ไฮดรอกซี-โอเมก้า-อะริล-อัลคาโนอิคแอซิดเอไมด์ชนิดใหม่
FR2731438B1 (fr) Hydrolise enzymatique des 4-methylthiobutyronitriles
DK38993D0 (da) Enzym
DK114193D0 (da) Enzym
DK48593D0 (da) Enzym
DK112693D0 (da) Enzym