CY2055B1 - N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives - Google Patents

N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives

Info

Publication number: CY2055B1
Authority: CY; Cyprus
Prior art keywords: glutamic acid; hydrogen; tetrahydropyrido; alkanoyl; pyrimidin
Prior art date: 1988-05-25

Application number

CY9802055A

Other languages

English (en)

Original Assignee

Univ Princeton

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-25

Filing date

1998-06-12

Publication date

1998-06-12

1988-05-25 Priority claimed from US07/198,201 external-priority patent/US4882333A/en

1988-05-25 Priority claimed from US07/198,207 external-priority patent/US4882334A/en

1998-06-12 Application filed by Univ Princeton, Lilly Co Eli filed Critical Univ Princeton

1998-06-12 Publication of CY2055B1 publication Critical patent/CY2055B1/xx

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000004956 cyclohexylene group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
150000002306 glutamic acid derivatives Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrane Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)

CY9802055A 1988-05-25 1998-06-12 N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives CY2055B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/198,201 US4882333A (en)	1988-05-25	1988-05-25	N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
US07/198,207 US4882334A (en)	1988-05-25	1988-05-25	N-(5,6,7,8-tetrahydropyrido]2,3-d]pyrimidin-6-ylethl-thineyl-and furylcarbonyl)-glutamic acid derivatives

Publications (1)

Publication Number	Publication Date
CY2055B1 true CY2055B1 (en)	1998-06-12

Family

ID=26893557

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY9802055A CY2055B1 (en)	1988-05-25	1998-06-12	N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives

Country Status (18)

Country	Link
EP (1)	EP0343801B1 (de)
JP (1)	JP2818198B2 (de)
KR (1)	KR0131589B1 (de)
CN (1)	CN1025334C (de)
AT (1)	ATE109480T1 (de)
AU (1)	AU611027B2 (de)
CA (1)	CA1340631C (de)
CY (1)	CY2055B1 (de)
DE (1)	DE68917211T2 (de)
DK (1)	DK172753B1 (de)
ES (1)	ES2057116T3 (de)
HK (1)	HK1000284A1 (de)
HU (1)	HU205356B (de)
IE (1)	IE63620B1 (de)
IL (1)	IL90179A (de)
NZ (1)	NZ229242A (de)
PT (1)	PT90635B (de)
RU (1)	RU2002747C1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH03173890A (ja) *	1989-09-21	1991-07-29	Takeda Chem Ind Ltd	ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
IL96531A (en) *	1989-12-11	1995-08-31	Univ Princeton	History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
CA2032695A1 (en) *	1989-12-20	1991-06-21	Hiroshi Akimoto	Condensed heterocyclic compounds, their production and use
CZ66893A3 (en) *	1992-04-23	1993-12-15	Lilly Co Eli	Application of gar - transformylase inhibitor
US5608082A (en) *	1994-07-28	1997-03-04	Agouron Pharmaceuticals, Inc.	Compounds useful as antiproliferative agents and GARFT inhibitors
FI971953A7 (fi) *	1994-11-14	1997-05-12	Warner Lambert Co	Proteiinityrosiinikinaasin välittämää soluproliferaatiota inhiboivat 6 -aryyli-pyrido(2,3-d)pyrimidiinit ja naftyridiinit
ATE212632T1 (de) *	1995-09-08	2002-02-15	Univ Princeton	Nicht-klassische antifolate
CA2251813A1 (en) *	1996-05-01	1997-11-06	The Trustees Of Princeton University	5,6,7,8-tetrahydropyrido[2,3-d]pyrimidines
US6426417B1 (en) *	1998-02-11	2002-07-30	Eli Lilly And Company	Processes and intermediates useful to make antifolates
RU2305677C2 (ru) *	2001-12-27	2007-09-10	Адзиномото Ко., Инк.	Способы получения производных глутаминовой кислоты, способы получения промежуточных соединений и новое промежуточное соединение для данных способов
KR101160473B1 (ko) *	2003-01-09	2012-06-28	아지노모토 가부시키가이샤	글루탐산 유도체 및 피로글루탐산 유도체의 제조 방법 및신규 제조 중간체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4684653A (en) *	1985-03-08	1987-08-04	The Trustees Of Princeton University	Pyrido(2,3-d)pyrimidine derivatives
ZA861235B (en) *	1985-03-08	1986-10-29	Univ Princeton	Pyrido(2,3-d)pyrimidine derivatives
NZ219971A (en) *	1986-06-06	1989-08-29	Univ Princeton	Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
IE60038B1 (en) *	1986-06-30	1994-05-18	Univ Princeton	4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives

1989
- 1989-05-02 DK DK198902152A patent/DK172753B1/da not_active IP Right Cessation
- 1989-05-03 IL IL9017989A patent/IL90179A/en not_active IP Right Cessation
- 1989-05-04 DE DE68917211T patent/DE68917211T2/de not_active Expired - Fee Related
- 1989-05-04 AT AT89304499T patent/ATE109480T1/de not_active IP Right Cessation
- 1989-05-04 ES ES89304499T patent/ES2057116T3/es not_active Expired - Lifetime
- 1989-05-04 EP EP89304499A patent/EP0343801B1/de not_active Expired - Lifetime
- 1989-05-17 CA CA000599937A patent/CA1340631C/en not_active Expired - Fee Related
- 1989-05-23 PT PT90635A patent/PT90635B/pt not_active IP Right Cessation
- 1989-05-23 NZ NZ229242A patent/NZ229242A/xx unknown
- 1989-05-24 AU AU35109/89A patent/AU611027B2/en not_active Ceased
- 1989-05-24 RU SU894614259A patent/RU2002747C1/ru active
- 1989-05-25 KR KR1019890007041A patent/KR0131589B1/ko not_active Expired - Fee Related
- 1989-05-25 JP JP1132541A patent/JP2818198B2/ja not_active Expired - Lifetime
- 1989-05-25 CN CN89103686A patent/CN1025334C/zh not_active Expired - Fee Related
- 1989-05-25 HU HU892684A patent/HU205356B/hu not_active IP Right Cessation
- 1989-06-12 IE IE176789A patent/IE63620B1/en not_active IP Right Cessation
1997
- 1997-09-24 HK HK97101830A patent/HK1000284A1/en not_active IP Right Cessation
1998
- 1998-06-12 CY CY9802055A patent/CY2055B1/xx unknown

Also Published As

Publication number	Publication date
DE68917211D1 (de)	1994-09-08
EP0343801B1 (de)	1994-08-03
DK215289A (da)	1989-11-26
DK172753B1 (da)	1999-06-28
NZ229242A (en)	1990-10-26
JPH0267281A (ja)	1990-03-07
RU2002747C1 (ru)	1993-11-15
AU611027B2 (en)	1991-05-30
AU3510989A (en)	1989-11-30
IL90179A0 (en)	1989-12-15
ES2057116T3 (es)	1994-10-16
EP0343801A2 (de)	1989-11-29
ATE109480T1 (de)	1994-08-15
IE63620B1 (en)	1995-05-17
IL90179A (en)	1994-02-27
HUT50342A (en)	1990-01-29
PT90635A (pt)	1989-11-30
CN1025334C (zh)	1994-07-06
IE891767L (en)	1989-11-25
KR900018100A (ko)	1990-12-20
KR0131589B1 (ko)	1998-04-17
PT90635B (pt)	1994-10-31
DK215289D0 (da)	1989-05-02
CN1038098A (zh)	1989-12-20
EP0343801A3 (de)	1991-05-02
HU205356B (en)	1992-04-28
HK1000284A1 (en)	1998-02-20
JP2818198B2 (ja)	1998-10-30
DE68917211T2 (de)	1994-11-24
CA1340631C (en)	1999-07-06

Publication	Publication Date	Title
AU3821889A (en)	1990-01-25	4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
DE3660010D1 (en)	1988-02-04	Peptide derivatives with a polycyclic nitrogen structure, process for their preparation and pharmaceutical compositions containing them
NO890723D0 (no)	1989-02-21	Fremgangsmaate for fremstilling av terapeutisk aktive 3-alkenyl-1-azabicyklo(3.2.0)hept2-en-2-karboksylsyrederivater.
IL110151A0 (en)	1994-10-07	Amide and urea derivatives and pharmaceutical compositions containing the same
EP0193904A3 (en)	1988-09-07	Amino acid derivatives and processes for preparation thereof
AU3510989A (en)	1989-11-30	N-(5,6,7,8-tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl) -glutamic acid derivatives
GR3001874T3 (en)	1992-11-23	Process for the preparation of n-alkylated amino acids and their esters, use in the synthesis of carboxyalkyl dipeptides
TW273553B (de)	1996-04-01
HU895648D0 (en)	1990-01-28	Process for the preparation of n,n-disubstituted diaryl-alkancarboxylic acid amide derivatives and pharmaceutical compositions containing such compounds
AU580162B2 (en)	1989-01-05	1,3-oxathiane derivatives
DE3665593D1 (en)	1989-10-19	Peptide immunostimulants
EP0408106A3 (en)	1991-04-24	Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine
ATE92461T1 (de)	1993-08-15	Gegen die zerebrale insuffizienz wirksame verbindungen.