CY2057B1 - Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents - Google Patents

Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents

Info

Publication number: CY2057B1
Authority: CY; Cyprus
Prior art keywords: oxime; chem; hydrogen; independently; arylamino
Prior art date: 1990-08-08

Application number

CY9802057A

Other languages

English (en)

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-08

Filing date

1998-04-30

Publication date

1998-04-30

1998-04-30 Application filed by American Home Prod filed Critical American Home Prod

1998-04-30 Publication of CY2057B1 publication Critical patent/CY2057B1/xx

Links

229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
229940124630 bronchodilator Drugs 0.000 title 1
239000000168 bronchodilator agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000001769 aryl amino group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
-1 loweralkylamino Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
108010044467 Isoenzymes Proteins 0.000 abstract 1
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
230000003182 bronchodilatating effect Effects 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
229940095074 cyclic amp Drugs 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
210000004969 inflammatory cell Anatomy 0.000 abstract 1
208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
150000002923 oximes Chemical class 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
230000002685 pulmonary effect Effects 0.000 abstract 1
210000002460 smooth muscle Anatomy 0.000 abstract 1
210000001519 tissue Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/62—Oximes having oxygen atoms of oxyimino groups esterified
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Polyesters Or Polycarbonates (AREA)
Reinforced Plastic Materials (AREA)
Quinoline Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CY9802057A 1990-08-08 1998-04-30 Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents CY2057B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/564,263 US5124455A (en)	1990-08-08	1990-08-08	Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents

Publications (1)

Publication Number	Publication Date
CY2057B1 true CY2057B1 (en)	1998-04-30

Family

ID=24253782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY9802057A CY2057B1 (en)	1990-08-08	1998-04-30	Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents

Country Status (24)

Country	Link
US (1)	US5124455A (cs)
EP (1)	EP0470805B1 (cs)
JP (1)	JP2651292B2 (cs)
KR (1)	KR920004335A (cs)
CN (1)	CN1029613C (cs)
AT (1)	ATE111076T1 (cs)
AU (1)	AU640251B2 (cs)
CA (1)	CA2048518A1 (cs)
CS (1)	CS245091A3 (cs)
CY (1)	CY2057B1 (cs)
DE (1)	DE69103846T2 (cs)
DK (1)	DK0470805T3 (cs)
ES (1)	ES2060307T3 (cs)
FI (1)	FI913738A7 (cs)
GB (1)	GB2246777B (cs)
HU (3)	HU207289B (cs)
IE (1)	IE66049B1 (cs)
IL (1)	IL99081A (cs)
MX (1)	MX9100549A (cs)
NO (1)	NO174805B (cs)
NZ (1)	NZ239279A (cs)
PT (1)	PT98596B (cs)
RU (1)	RU2051145C1 (cs)
ZA (1)	ZA916154B (cs)

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US4475945A (en) *	1980-01-14	1984-10-09	Ciba-Geigy Corporation	Aminoglyoxyloitrile oximino carboxylic acid esters and thio esters for the protection of crops against injury by herbicides
DE3438839A1 (de) *	1984-10-19	1986-04-24	Schering AG, 1000 Berlin und 4709 Bergkamen	Pharmazeutische praeparate
EP0186817B1 (en) *	1984-12-10	1989-08-02	Nissan Chemical Industries Ltd.	3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it
FI875724A0 (fi) *	1986-04-29	1987-12-28	Pfizer	Av kalcium oberoende camp fosfodiesteras-inhibitordepressant.
GB8711802D0 (en) *	1987-05-19	1987-06-24	Fujisawa Pharmaceutical Co	Dithioacetal compounds
RU2104306C1 (ru) *	1989-11-13	1998-02-10	Пфайзер Инк.	Способ получения оптически активного (2s)- или (2r)-эндо-бицикло[2.2.1]гептан-2-ола, способ получения 5-(3-[(2r)-экзо-бицикло[2.2.1]гепт-2-илокси]-4-метоксифенил)-3,4,5,6-тетрагидропиримидин-2(1н)-она, оптически активный 5-(3-[экзо-бицикло[2.2.1]гепт-2-илокси]4-метоксифенил)-3,4,5,6-тетрагидропиримидин-2(1н)-он, оптически активные промежуточные соединения и способ их получения

1990
- 1990-08-08 US US07/564,263 patent/US5124455A/en not_active Expired - Fee Related
1991
- 1991-08-05 JP JP3195183A patent/JP2651292B2/ja not_active Expired - Lifetime
- 1991-08-05 ZA ZA916154A patent/ZA916154B/xx unknown
- 1991-08-05 IL IL9908191A patent/IL99081A/en unknown
- 1991-08-05 AU AU81623/91A patent/AU640251B2/en not_active Ceased
- 1991-08-06 FI FI913738A patent/FI913738A7/fi unknown
- 1991-08-06 KR KR1019910013552A patent/KR920004335A/ko not_active Abandoned
- 1991-08-06 DK DK91307197.3T patent/DK0470805T3/da active
- 1991-08-06 NZ NZ239279A patent/NZ239279A/xx unknown
- 1991-08-06 DE DE69103846T patent/DE69103846T2/de not_active Expired - Fee Related
- 1991-08-06 MX MX9100549A patent/MX9100549A/es unknown
- 1991-08-06 GB GB9116950A patent/GB2246777B/en not_active Expired - Fee Related
- 1991-08-06 ES ES91307197T patent/ES2060307T3/es not_active Expired - Lifetime
- 1991-08-06 AT AT91307197T patent/ATE111076T1/de active
- 1991-08-06 EP EP91307197A patent/EP0470805B1/en not_active Expired - Lifetime
- 1991-08-07 HU HU912634A patent/HU207289B/hu not_active IP Right Cessation
- 1991-08-07 HU HU9202417A patent/HU215159B/hu not_active IP Right Cessation
- 1991-08-07 RU SU915001278A patent/RU2051145C1/ru active
- 1991-08-07 NO NO913065A patent/NO174805B/no unknown
- 1991-08-07 IE IE279491A patent/IE66049B1/en not_active IP Right Cessation
- 1991-08-07 CA CA002048518A patent/CA2048518A1/en not_active Abandoned
- 1991-08-07 CN CN91105530A patent/CN1029613C/zh not_active Expired - Fee Related
- 1991-08-07 PT PT98596A patent/PT98596B/pt not_active IP Right Cessation
- 1991-08-07 CS CS912450A patent/CS245091A3/cs unknown
1995
- 1995-06-28 HU HU95P/P00483P patent/HU211643A9/hu unknown
1998
- 1998-04-30 CY CY9802057A patent/CY2057B1/xx unknown

Also Published As

Publication number	Publication date
MX9100549A (es)	1992-04-01
ES2060307T3 (es)	1994-11-16
NO174805C (cs)	1994-07-13
ZA916154B (en)	1993-04-28
JPH04253945A (ja)	1992-09-09
DK0470805T3 (da)	1994-10-17
HUT61273A (en)	1992-12-28
DE69103846D1 (de)	1994-10-13
KR920004335A (ko)	1992-03-27
HU211643A9 (en)	1995-12-28
HU912634D0 (en)	1992-01-28
FI913738A0 (fi)	1991-08-06
AU640251B2 (en)	1993-08-19
GB2246777A (en)	1992-02-12
IE912794A1 (en)	1992-02-12
HK1000103A1 (en)	1997-11-28
ATE111076T1 (de)	1994-09-15
EP0470805A1 (en)	1992-02-12
US5124455A (en)	1992-06-23
JP2651292B2 (ja)	1997-09-10
FI913738A7 (fi)	1992-02-09
CN1029613C (zh)	1995-08-30
NZ239279A (en)	1993-09-27
HUT58694A (en)	1992-03-30
RU2051145C1 (ru)	1995-12-27
NO913065D0 (no)	1991-08-07
GB2246777B (en)	1994-08-17
GB9116950D0 (en)	1991-09-18
NO913065L (no)	1992-02-10
PT98596B (pt)	1999-03-31
NO174805B (no)	1994-04-05
IL99081A0 (en)	1992-07-15
IE66049B1 (en)	1995-12-13
DE69103846T2 (de)	1995-01-12
IL99081A (en)	1995-05-26
CA2048518A1 (en)	1992-02-09
PT98596A (pt)	1992-07-31
CS245091A3 (en)	1992-03-18
HU215159B (hu)	1998-12-28
HU207289B (en)	1993-03-29
AU8162391A (en)	1992-02-13
CN1058771A (zh)	1992-02-19
EP0470805B1 (en)	1994-09-07

Publication	Publication Date	Title
GB2246777B (en)	1994-08-17	Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
GR3025920T3 (en)	1998-04-30	Triazolopyrimidine derivatives with fungicidal activity
PL293316A1 (en)	1993-08-23	Method of obtaining quinozolinone derivatives
DK0756595T3 (da)	2002-06-17	Substituerede 1,3-oxathiolaner med antivirale egenskaber
IL114061A0 (en)	1995-10-31	Methods of administering crf antagonists
IE893230L (en)	1990-04-07	Hydrocarbon substituted pyrrolidinones
TW197944B (cs)	1993-01-11
EP0201350A3 (en)	1987-10-28	1,3-oxathiane derivatives
ES8704961A1 (es)	1987-04-16	Procedimiento para preparar n6-benzopirano- y benzotiopira- no-adenosinas
IE890977L (en)	1989-09-24	Isoxazolinones
GR3004091T3 (cs)	1993-03-31
EP0490598B1 (en)	1996-05-22	Antitumor and antiviral compound
TH33845A (cs)	1999-07-16
GR3029624T3 (en)	1999-06-30	New process for preparing 2'-(diethylamino)rifamycin P (P/DEA)