ATE413398T1 - Thioamidderivate als progesteronrezeptormodulatoren - Google Patents

Thioamidderivate als progesteronrezeptormodulatoren

Info

Publication number: ATE413398T1
Authority: AT; Austria
Prior art keywords: receptor modulators; progesterone receptor; thioamide; thioamide derivatives; compounds
Prior art date: 2004-04-08

Application number

AT05735464T

Other languages

English (en)

Inventor

Bogdan Wilk

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-08

Filing date

2005-04-07

Publication date

2008-11-15

2005-04-07 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE413398T1 publication Critical patent/ATE413398T1/de

Links

150000003556 thioamides Chemical class 0.000 title abstract 3
239000002379 progesterone receptor modulator Substances 0.000 title abstract 2
229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title abstract 2
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
-1 and specifically Chemical class 0.000 abstract 2
229960003387 progesterone Drugs 0.000 abstract 1
239000000186 progesterone Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Ink Jet (AREA)

AT05735464T 2004-04-08 2005-04-07 Thioamidderivate als progesteronrezeptormodulatoren ATE413398T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56056904P	2004-04-08	2004-04-08

Publications (1)

Publication Number	Publication Date
ATE413398T1 true ATE413398T1 (de)	2008-11-15

Family

ID=34965700

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05735464T ATE413398T1 (de)	2004-04-08	2005-04-07	Thioamidderivate als progesteronrezeptormodulatoren

Country Status (14)

Country	Link
US (4)	US7358246B2 (de)
EP (1)	EP1732921B1 (de)
JP (1)	JP4869221B2 (de)
CN (1)	CN100522960C (de)
AT (1)	ATE413398T1 (de)
AU (1)	AU2005233591B2 (de)
BR (1)	BRPI0509209A (de)
CA (1)	CA2561014C (de)
DE (1)	DE602005010840D1 (de)
DK (1)	DK1732921T3 (de)
ES (1)	ES2317223T3 (de)
MX (1)	MXPA06011696A (de)
PL (1)	PL1732921T3 (de)
WO (1)	WO2005100346A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE409699T1 (de) *	2004-04-08	2008-10-15	Wyeth Corp	Verfahren zur minimierung von thioamidverunreinigungen
ATE413398T1 (de) *	2004-04-08	2008-11-15	Wyeth Corp	Thioamidderivate als progesteronrezeptormodulatoren
GT200500185A (es) *	2004-08-09	2006-04-10		Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
US20070093548A1 (en) *	2005-10-25	2007-04-26	Wyeth	Use of progesterone receptor modulators
WO2008021338A2 (en) *	2006-08-15	2008-02-21	Wyeth	Tricyclic oxazolidone derivatives useful as pr modulators
BRPI0819571A2 (pt) *	2007-12-20	2019-09-24	Teva Womenss Health Inc	"método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica"
CN107281215A (zh) *	2016-04-01	2017-10-24	复旦大学附属妇产科医院	硫化氢供体硫氢化钠在制药中的用途

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US3598123A (en)	1969-04-01	1971-08-10	Alza Corp	Bandage for administering drugs
US3845770A (en)	1972-06-05	1974-11-05	Alza Corp	Osmatic dispensing device for releasing beneficial agent
US3916899A (en)	1973-04-25	1975-11-04	Alza Corp	Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en)	1976-02-02	1977-02-22	Alza Corporation	Osmotic system having laminar arrangement for programming delivery of active agent
US4295987A (en)	1979-12-26	1981-10-20	The Procter & Gamble Company	Cross-linked sodium polyacrylate absorbent
US4959217A (en)	1986-05-22	1990-09-25	Syntex (U.S.A.) Inc.	Delayed/sustained release of macromolecules
AU608891B2 (en)	1987-09-24	1991-04-18	Merck & Co., Inc.	Solubility modulated drug delivery device
US5273752A (en)	1989-07-18	1993-12-28	Alza Corporation	Controlled release dispenser comprising beneficial agent
US5124455A (en)	1990-08-08	1992-06-23	American Home Products Corporation	Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
US5459151A (en)	1993-04-30	1995-10-17	American Home Products Corporation	N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents
US5854388A (en)	1993-06-24	1998-12-29	Washington State University Research Foundation	Angiotensin IV peptides and receptor
US5817343A (en)	1996-05-14	1998-10-06	Alkermes, Inc.	Method for fabricating polymer-based controlled-release devices
US5756127A (en)	1996-10-29	1998-05-26	Wright Medical Technology, Inc.	Implantable bioresorbable string of calcium sulfate beads
FI971385A0 (fi)	1997-04-04	1997-04-04	Bioxid Oy	Biokompatibel komposition, metoder foer dess framstaellning samt anvaendning daerav
US6407101B1 (en) *	1999-05-04	2002-06-18	American Home Products Corporation	Cyanopyrroles
US6417214B1 (en)	1999-05-04	2002-07-09	Wyeth	3,3-substituted indoline derivatives
US6355648B1 (en) *	1999-05-04	2002-03-12	American Home Products Corporation	Thio-oxindole derivatives
EA005034B1 (ru) *	1999-05-04	2004-10-28	Америкэн Хоум Продактс Корпорейшн	Производные тиооксиндола
ATE386729T1 (de) *	1999-05-04	2008-03-15	Wyeth Corp	Cyclothiocarbamatderivate als progesteron- rezeptormodulatoren
US6509334B1 (en)	1999-05-04	2003-01-21	American Home Products Corporation	Cyclocarbamate derivatives as progesterone receptor modulators
US6391907B1 (en)	1999-05-04	2002-05-21	American Home Products Corporation	Indoline derivatives
MXPA02001471A (es)	1999-08-10	2002-07-02	Smithkline Beecham Corp	4,4-diaril ciclohexanos 1,4-substituidos.
US6258833B1 (en)	1999-12-23	2001-07-10	Icos Corporation	Cyclic AMP-specific phosphodiesterase inhibitors
UA73119C2 (en) *	2000-04-19	2005-06-15	American Home Products Corpoir	Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
JP4716547B2 (ja) *	2000-08-10	2011-07-06	住友精化株式会社	２−フェニルチアゾール類の製造方法
US20030225273A1 (en) *	2002-03-21	2003-12-04	Michaelides Michael R.	Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
AU2003241960B2 (en) *	2002-06-06	2009-07-30	Eisai R&D Management Co., Ltd.	Novel fused imidazole derivative
RU2005101638A (ru)	2002-06-25	2006-01-20	Уайт (Us)	Использование циклокарбаматных производных для лечения гормонзависимых состояний
KR20050012831A (ko)	2002-06-25	2005-02-02	와이어쓰	피부 질환을 치료하는 데 있어서의 티오-옥스인돌유도체의 용도
US7268149B2 (en) *	2002-06-25	2007-09-11	Wyeth	Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders
RU2005101635A (ru)	2002-06-25	2005-08-10	Уайт (Us)	Применение производных тиооксиндола в терапии гормонозависимых состояний
ATE413398T1 (de) *	2004-04-08	2008-11-15	Wyeth Corp	Thioamidderivate als progesteronrezeptormodulatoren
US7122705B2 (en) *	2004-04-08	2006-10-17	Wyeth	Method for preparing 3-cyclopentyloxy-4-methoxybenzaldehyde
ATE409699T1 (de) *	2004-04-08	2008-10-15	Wyeth Corp	Verfahren zur minimierung von thioamidverunreinigungen
EP1756072A2 (de) *	2004-04-27	2007-02-28	Wyeth	Reinigung von progesteronrezeptor-modulatoren

2005
- 2005-04-07 AT AT05735464T patent/ATE413398T1/de not_active IP Right Cessation
- 2005-04-07 PL PL05735464T patent/PL1732921T3/pl unknown
- 2005-04-07 ES ES05735464T patent/ES2317223T3/es not_active Expired - Lifetime
- 2005-04-07 DK DK05735464T patent/DK1732921T3/da active
- 2005-04-07 EP EP05735464A patent/EP1732921B1/de not_active Expired - Lifetime
- 2005-04-07 MX MXPA06011696A patent/MXPA06011696A/es active IP Right Grant
- 2005-04-07 AU AU2005233591A patent/AU2005233591B2/en not_active Ceased
- 2005-04-07 WO PCT/US2005/011757 patent/WO2005100346A1/en not_active Ceased
- 2005-04-07 BR BRPI0509209-4A patent/BRPI0509209A/pt not_active IP Right Cessation
- 2005-04-07 JP JP2007507494A patent/JP4869221B2/ja not_active Expired - Fee Related
- 2005-04-07 DE DE602005010840T patent/DE602005010840D1/de not_active Expired - Lifetime
- 2005-04-07 CN CNB2005800108301A patent/CN100522960C/zh not_active Expired - Fee Related
- 2005-04-07 CA CA2561014A patent/CA2561014C/en not_active Expired - Fee Related
- 2005-04-07 US US11/100,860 patent/US7358246B2/en not_active Expired - Fee Related
2008
- 2008-03-07 US US12/044,287 patent/US7511071B2/en not_active Expired - Fee Related
2009
- 2009-02-12 US US12/369,789 patent/US7659265B2/en not_active Expired - Fee Related
2010
- 2010-02-02 US US12/698,472 patent/US8168672B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MXPA06011696A (es)	2006-12-14
BRPI0509209A (pt)	2007-08-28
CA2561014A1 (en)	2005-10-27
US7511071B2 (en)	2009-03-31
US20090143345A1 (en)	2009-06-04
US20050227971A1 (en)	2005-10-13
JP2007532564A (ja)	2007-11-15
US7358246B2 (en)	2008-04-15
DE602005010840D1 (de)	2008-12-18
ES2317223T3 (es)	2009-04-16
EP1732921A1 (de)	2006-12-20
CN100522960C (zh)	2009-08-05
US20080167299A1 (en)	2008-07-10
AU2005233591A1 (en)	2005-10-27
PL1732921T3 (pl)	2009-04-30
US20100197645A1 (en)	2010-08-05
CN1938299A (zh)	2007-03-28
JP4869221B2 (ja)	2012-02-08
DK1732921T3 (da)	2009-02-23
AU2005233591B2 (en)	2011-10-27
CA2561014C (en)	2013-09-10
EP1732921B1 (de)	2008-11-05
WO2005100346A1 (en)	2005-10-27
US7659265B2 (en)	2010-02-09
US8168672B2 (en)	2012-05-01

Legal Events

Date	Code	Title	Description
2009-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
TW200605882A (en)	2006-02-16	Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof
TW200607798A (en)	2006-03-01	Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof
BRPI0510170B8 (pt)	2021-05-25	composto, composição farmacêutica para o tratamento de doenças mediadas pelo receptor muscarínico de acetilcolina e uso do composto
CL2008002540A1 (es)	2009-07-17	Compuestos derivados aza-indol-2,3-sustituidos; composicion farmaceutica; y uso ene l tratamiento de una infeccion viral.
WO2004011611A3 (en)	2004-08-12	Taci antibodies and uses thereof
DE602005026290D1 (de)	2011-03-24	Zusammensetzungen mit verzögerter freisetzung mit progesteron-rezeptormodulatoren
NO20070782L (no)	2007-04-02	Tetrapeptidanaloger.
DE602005009748D1 (de)	2008-10-23	3-phenyl-pyrazol-derivate als modulatoren des zur behandlung damit zusammenhängender störungen nützlichen 5-ht-2a-serotonin-rezeptors
CL2009000200A1 (es)	2010-09-10	Compuestos derivados de 2,7-naftiridinas-1-ona, mediadores de syk; composicion farmaceutica; y uso en el tratamiento de una enfermedad inflamatoria, respiratoria, proliferativa celular o autoinmune.
DK1654253T3 (da)	2007-04-30	Substituerede 3-pyrrolidinindolderivater
EE05536B1 (et)	2012-04-16	N-karbamoüülmetüül-4-(R)-fenüül-2-pürrolidinoon, selle valmistamise meetod ja farmatseutiline kasutamine
CL2008003659A1 (es)	2009-09-04	Compuestos derivados de 6-(4-bencilpiperazin-1-il)pirimidin-4-ona, moduladores de la enzima estearoil-coa-desaturasa 1; procedimiento de preparacion; composicin farmaceutica; y uso en el tratamiento y profilaxis de la obesidad.
IL180911A0 (en)	2007-07-04	N-(1h-indolyl)-1h-indole-2-carboxamide derivatives, their preparation and their therapeutic use
CO5660287A2 (es)	2006-07-31	Derivados de tetrahidrocarbazol y su uso farmaceutico
ATE399776T1 (de)	2008-07-15	Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors
DE60303376D1 (de)	2006-04-13	Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen
ATE399777T1 (de)	2008-07-15	Pyrrol-2,5-dionderivate als modulatoren des liver-x-rezeptors
ZA201001085B (en)	2011-04-28	Indol-2-one derivatives disubstituted in the 3-position,preparation thereof and therapeutic use thereof
IL177047A0 (en)	2006-12-10	Oxazole derivatives, preparation and therapeutic use thereof
ATE413398T1 (de)	2008-11-15	Thioamidderivate als progesteronrezeptormodulatoren
TWI367879B (en)	2012-07-11	N-(heteroaryl)-1h-indole-2-carboxamide derivatives, preparation thereof and therapeutic application thereof
EA200801430A1 (ru)	2008-12-30	Производные триазола
DK2185561T3 (da)	2011-10-10	Derivater af 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6-carboxamid og 2,3,4,5-tetrahydroprrolo(1,2-a)-diazepin-7-carboxamid, fremstilling deraf og terapeutisk anvendelse deraf
IL198481A0 (en)	2010-02-17	Pyrrole derivatives, preparation use of the same in therapy
IL180867A0 (en)	2007-07-04	Pyrrole derivatives, their preparation and their therapeutic use