CY2067A - Stereoselective glycosylation process - Google Patents

Stereoselective glycosylation process

Info

Publication number: CY2067A
Authority: CY; Cyprus
Prior art keywords: glycosylation process; stereoselective glycosylation; stereoselective; anomer; fluorocarbohydrate
Prior art date: 1992-06-22

Application number

CY206793A

Other languages

English (en)

Inventor

Ta-Sen Chou

Laurie Michelle Poteet

Douglas Patton Kjell

Cora Sue Grossman

Larry Wayne Hertel

Richard Elmer Holmes

Charles David Jones

Thomas Edward Mabry

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-22

Filing date

1993-06-21

Publication date

1993-06-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27583678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2067(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-06-22 Priority claimed from US07/902,312 external-priority patent/US5371210A/en

1993-04-07 Priority claimed from US08/044,345 external-priority patent/US5594124A/en

1993-04-07 Priority claimed from US08/044,996 external-priority patent/US5821357A/en

1993-04-07 Priority claimed from US08/044,343 external-priority patent/US5401838A/en

1993-04-07 Priority claimed from US08/044,312 external-priority patent/US5426183A/en

1993-06-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1993-06-21 Publication of CY2067A publication Critical patent/CY2067A/xx

Links

230000013595 glycosylation Effects 0.000 title abstract 2
238000006206 glycosylation reaction Methods 0.000 title abstract 2
230000000707 stereoselective effect Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
238000006073 displacement reaction Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
-1 sulfonyloxy group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CY206793A 1992-06-22 1993-06-21 Stereoselective glycosylation process CY2067A (en)

Applications Claiming Priority (12)

Application Number	Priority Date	Filing Date	Title
US90215092A	1992-06-22	1992-06-22
US90230292A	1992-06-22	1992-06-22
US90231392A	1992-06-22	1992-06-22
US90211292A	1992-06-22	1992-06-22
US90213592A	1992-06-22	1992-06-22
US07/902,312 US5371210A (en)	1992-06-22	1992-06-22	Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US4431593A	1993-04-07	1993-04-07
US4430993A	1993-04-07	1993-04-07
US08/044,345 US5594124A (en)	1992-06-22	1993-04-07	Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US08/044,996 US5821357A (en)	1992-06-22	1993-04-07	Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US08/044,343 US5401838A (en)	1992-06-22	1993-04-07	Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US08/044,312 US5426183A (en)	1992-06-22	1993-04-07	Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (1)

Publication Number	Publication Date
CY2067A true CY2067A (en)	1993-06-21

Family

ID=27583678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY206793A CY2067A (en)	1992-06-22	1993-06-21	Stereoselective glycosylation process

Country Status (20)

Country	Link
EP (1)	EP0577303B1 (es)
JP (1)	JP3313191B2 (es)
KR (1)	KR100252452B1 (es)
AT (1)	ATE158799T1 (es)
BR (1)	BR9302434A (es)
CA (1)	CA2098881C (es)
CY (1)	CY2067A (es)
DE (1)	DE69314239C5 (es)
DK (1)	DK0577303T3 (es)
ES (1)	ES2107624T3 (es)
FI (1)	FI108643B (es)
GR (1)	GR3025689T3 (es)
HU (2)	HU223837B1 (es)
IL (1)	IL106071A (es)
MX (1)	MX9303707A (es)
MY (1)	MY115775A (es)
NO (1)	NO180235B3 (es)
NZ (1)	NZ247939A (es)
PL (1)	PL172348B1 (es)
UA (1)	UA41261C2 (es)

Families Citing this family (35)

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US5606048A (en) *	1992-06-22	1997-02-25	Eli Lilly And Company	Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) *	1993-08-25	1995-06-13	Eli Lilly And Company	Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US5637688A (en) *	1994-12-13	1997-06-10	Eli Lilly And Company	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5559222A (en) *	1995-02-03	1996-09-24	Eli Lilly And Company	Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
AU1289697A (en)	1995-12-13	1997-07-03	Eli Lilly And Company	Alpha, alpha-difluoro-beta-hydroxy thiol esters and their synthesis
US6326507B1 (en)	1998-06-19	2001-12-04	Trustees Of Dartmouth College	Therapeutic compounds and methods of use
JP4555536B2 (ja)	2000-02-18	2010-10-06	サザン・リサーチ・インスティテュート	２−クロロ−９−（２−デオキシ−２−フルオロ−β−Ｄ−アラビノフラノシル）−９Ｈ−プリン−６−アミンの合成方法
US7435755B2 (en)	2000-11-28	2008-10-14	The Trustees Of Dartmouth College	CDDO-compounds and combination therapies thereof
ES2306783T3 (es) *	2001-08-02	2008-11-16	Ilex Oncology, Inc.	Procedimiento para preparar nucleosidos purinicos.
US7176237B2 (en)	2002-01-15	2007-02-13	The Trustees Of Dartmouth College	Tricyclic-bis-enone derivatives and methods of use thereof
US6884880B2 (en) *	2002-08-21	2005-04-26	Ash Stevens, Inc.	Process for the preparation of 9-β-anomeric nucleoside analogs
US7265096B2 (en)	2002-11-04	2007-09-04	Xenoport, Inc.	Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US8148505B2 (en)	2003-05-22	2012-04-03	Japan Science And Technology Agency	Method of α-selective glycosylation
WO2006070985A1 (en)	2004-12-30	2006-07-06	Hanmi Pharm. Co., Ltd.	METHOD FOR THE PREPARATION OF 2&num;-DEOXY-2&num;,2&num;-DIFLUOROCYTIDINE
KR20070112774A (ko) *	2005-03-04	2007-11-27	다브르 파마 리미티드	베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법
US7572898B2 (en) *	2005-06-03	2009-08-11	Scinopharm Taiwan, Ltd.	Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
CN100391966C (zh) *	2005-06-17	2008-06-04	华东师范大学	一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
US8921340B2 (en)	2006-11-17	2014-12-30	Trustees Of Dartmouth College	Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8299046B2 (en)	2006-11-17	2012-10-30	Trustees Of Dartmouth College	Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
WO2008064133A1 (en)	2006-11-17	2008-05-29	Trustees Of Dartmouth College	Synthesis and biological activities of new tricyclic-bis-enones (tbes)
US20080262215A1 (en) *	2007-04-23	2008-10-23	Chemagis Ltd.	Gemcitabine production process
CN100475832C (zh)	2007-05-31	2009-04-08	南京卡文迪许生物工程技术有限公司	一种新颖的高立体选择性合成吉西他滨工艺及中间体
EP2048151A1 (en) *	2007-10-10	2009-04-15	Cilag AG	Method for producing nucleosides by direct glycosylation of the nucleoside base
EP2050757A1 (en) *	2007-10-10	2009-04-22	Cilag AG	Method of producing 2' -deoxy-5-azacytidine (Decitabine)
HUE043175T2 (hu)	2008-01-11	2019-08-28	Reata Pharmaceuticals Inc	Szintetikus triterpenoidok és alkalmazásuk betegség kezelésében
CN104250280A (zh)	2008-04-18	2014-12-31	里亚塔医药公司	抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物
ES2703274T3 (es)	2008-04-18	2019-03-07	Reata Pharmaceuticals Inc	Moduladores de la inflamación antioxidantes: derivados del ácido oleanólico con modificaciones amino y otras en C-17
MX339476B (es)	2008-04-18	2016-05-27	Reata Pharmaceuticals Inc	Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
US8071632B2 (en)	2008-04-18	2011-12-06	Reata Pharmaceuticals, Inc.	Antioxidant inflammation modulators: novel derivatives of oleanolic acid
KR101713140B1 (ko)	2008-04-18	2017-03-08	리타 파마슈티컬스 잉크.	Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체
NZ700073A (en)	2012-04-04	2016-08-26	Halozyme Inc	Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
US8921419B2 (en)	2012-05-08	2014-12-30	Trustees Of Dartmouth College	Triterpenoids and compositions containing the same
CN105229020B (zh) *	2013-03-15	2018-09-25	表观遗传学药业有限责任公司	氟化嘧啶类似物及其使用方法
CA3061621A1 (en)	2017-04-26	2018-11-01	Thomas I. Kalman	Multitargeted nucleoside derivatives
US20190351031A1 (en)	2018-05-16	2019-11-21	Halozyme, Inc.	Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1295998C (en) *	1985-07-29	1992-02-18	Sai P. Sunkara	Nucleosides and their use as antineoplastic agents
DE3856477T2 (de) *	1987-08-28	2001-11-08	Eli Lilly And Co., Indianapolis	Verfahren zur Herstellung von 2'-deoxy-2',2'-difluornukleosiden
JPH0217199A (ja) *	1988-07-05	1990-01-22	Japan Tobacco Inc	２’−デオキシ−β−アデノシンの製造方法
GB8816345D0 (en) *	1988-07-08	1988-08-10	Hoffmann La Roche	Purine derivatives
HU906976D0 (en) *	1989-11-13	1991-05-28	Bristol Myers Squibb Co	Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
WO1991015498A2 (en) *	1990-04-04	1991-10-17	Nycomed Imaging As	Nucleoside derivatives
US5817799A (en) *	1990-07-23	1998-10-06	The United States Of America As Represented By The Department Of Health And Human Services	2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5371210A (en) *	1992-06-22	1994-12-06	Eli Lilly And Company	Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5256798A (en) *	1992-06-22	1993-10-26	Eli Lilly And Company	Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

1993
- 1993-06-18 UA UA93003070A patent/UA41261C2/uk unknown
- 1993-06-19 MY MYPI93001200A patent/MY115775A/en unknown
- 1993-06-21 HU HU0201196A patent/HU223837B1/hu active IP Right Grant
- 1993-06-21 ES ES93304817T patent/ES2107624T3/es not_active Expired - Lifetime
- 1993-06-21 EP EP93304817A patent/EP0577303B1/en not_active Expired - Lifetime
- 1993-06-21 CA CA002098881A patent/CA2098881C/en not_active Expired - Lifetime
- 1993-06-21 AT AT93304817T patent/ATE158799T1/de active
- 1993-06-21 DK DK93304817.5T patent/DK0577303T3/da active
- 1993-06-21 JP JP14913093A patent/JP3313191B2/ja not_active Expired - Lifetime
- 1993-06-21 IL IL106071A patent/IL106071A/en not_active IP Right Cessation
- 1993-06-21 MX MX9303707A patent/MX9303707A/es unknown
- 1993-06-21 BR BR9302434A patent/BR9302434A/pt not_active Application Discontinuation
- 1993-06-21 KR KR1019930011312A patent/KR100252452B1/ko not_active Ceased
- 1993-06-21 PL PL93299415A patent/PL172348B1/pl unknown
- 1993-06-21 HU HU9301822A patent/HUT64358A/hu unknown
- 1993-06-21 FI FI932869A patent/FI108643B/fi not_active IP Right Cessation
- 1993-06-21 DE DE69314239T patent/DE69314239C5/de not_active Expired - Lifetime
- 1993-06-21 CY CY206793A patent/CY2067A/xx unknown
- 1993-06-21 NO NO19932288A patent/NO180235B3/no not_active IP Right Cessation
- 1993-06-21 NZ NZ247939A patent/NZ247939A/xx not_active IP Right Cessation
1997
- 1997-12-16 GR GR970403339T patent/GR3025689T3/el unknown

Also Published As

Publication number	Publication date
MX9303707A (es)	1994-06-30
HU223837B1 (hu)	2005-02-28
FI108643B (fi)	2002-02-28
DE69314239C5 (de)	2012-11-29
NO180235B (no)	1996-12-02
KR100252452B1 (en)	2000-04-15
JPH06157570A (ja)	1994-06-03
DE69314239T2 (de)	1998-02-19
NO180235B3 (no)	2007-10-01
CA2098881A1 (en)	1993-12-23
IL106071A (en)	2006-08-20
GR3025689T3 (en)	1998-03-31
KR940005658A (ko)	1994-03-22
NO932288A (no)	1993-12-23
NZ247939A (en)	1996-02-27
CA2098881C (en)	2005-06-07
DE69314239D1 (de)	1997-11-06
EP0577303B1 (en)	1997-10-01
ES2107624T3 (es)	1997-12-01
FI932869L (fi)	1993-12-23
NO180235C (no)	1997-03-12
DK0577303T3 (da)	1997-10-27
EP0577303A1 (en)	1994-01-05
BR9302434A (pt)	1994-02-16
IL106071A0 (en)	1993-10-20
PL299415A1 (en)	1994-03-07
ATE158799T1 (de)	1997-10-15
HU9301822D0 (en)	1993-09-28
FI932869A0 (fi)	1993-06-21
PL172348B1 (pl)	1997-09-30
NO932288D0 (no)	1993-06-21
HUT64358A (en)	1993-12-28
HU0201196D0 (es)	2002-06-29
MY115775A (en)	2003-09-30
JP3313191B2 (ja)	2002-08-12
UA41261C2 (uk)	2001-09-17

Publication	Publication Date	Title
HU0201196D0 (es)	2002-06-29
GB8803405D0 (en)	1988-03-16	Lightweight refractory & process for producing same
AU7224887A (en)	1987-11-19	Process for the printing of shaped articles derived from aramid fibers
HUT45243A (en)	1988-06-28	Process for producing cis-1-aryl-2-(fluoromethyl)-oxiranes
HUT43619A (en)	1987-11-30	Process for producing 5-amino-4-hydroxy-valeril-derivatives substituted with sulfur-containing groups
EP0223199A3 (en)	1989-07-12	Process for producing high-strenght, high-modulus carbon fibers
EP0439184A3 (en)	1992-01-08	Carbon fiber structure and process for producing the same
PT86364A (en)	1988-01-01	Process for producing antibiotic a10255 complex
EP0165465A3 (en)	1988-08-17	Process for producing carbon fibers
HUT64551A (en)	1994-01-28	A method for spearating 2-desoxi-2,2-difluorine-d-ribo furanosyle-alkyl-sulfonate anomers
HU891329D0 (en)	1990-07-28	Process for producing beta silicion carbide
EP0482560A3 (en)	1993-04-07	Process for spinning pitch
US4777596B1 (en)	1996-06-25	Text replacement typing aid for computerized text editor
EP0526787A3 (en)	1993-03-10	Process for producing pitch-based carbon fiber
DE3571991D1 (en)	1989-09-07	Process for preparing antibiotic l 17392 (deglucoteicoplanin)
GB2101575B (en)	1985-07-17	Process for producing carbon fibers
HUT58341A (en)	1992-02-28	Process for producing 2',3'4'-tris(acetyl)-4,6'-ethylidene-beta-d-glycopyranizides
PH21036A (en)	1987-06-30	Process for producing antibiotic a80190
PT85445A (en)	1987-08-01	Process for producing antibiotic ll-42067 alpha
HUT49377A (en)	1989-09-28	Process for producing polyether antibiotic a 80577
IL83976A0 (en)	1988-02-29	Process for producing glycopeptide antibiotic
IL102144A0 (en)	1993-01-14	Process for producing 2'-deoxy-2',2'-difluoro nucleosides
CS66791A3 (en)	1992-09-16	Process for preparing 5-azacytosine nucleosides
IE872065L (en)	1988-01-31	Process for producing antibiotic ll-d42067
PL240921A1 (en)	1984-09-10	Process for preparing erythromycin 2'-esters