ES2107624T3 - Procedimiento de glucosilacion estereoselectivo. - Google Patents

Procedimiento de glucosilacion estereoselectivo.

Info

Publication number
ES2107624T3
ES2107624T3 ES93304817T ES93304817T ES2107624T3 ES 2107624 T3 ES2107624 T3 ES 2107624T3 ES 93304817 T ES93304817 T ES 93304817T ES 93304817 T ES93304817 T ES 93304817T ES 2107624 T3 ES2107624 T3 ES 2107624T3
Authority
ES
Spain
Prior art keywords
stereoselective
glucosilation
procedure
fluocarbohydrate
fluoronucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93304817T
Other languages
English (en)
Inventor
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Cora Sue Grossman
Larry Wayne Hertel
Richard Elmer Holmes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27583678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2107624(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/902,312 external-priority patent/US5371210A/en
Priority claimed from US08/044,996 external-priority patent/US5821357A/en
Priority claimed from US08/044,343 external-priority patent/US5401838A/en
Priority claimed from US08/044,312 external-priority patent/US5426183A/en
Priority claimed from US08/044,345 external-priority patent/US5594124A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2107624T3 publication Critical patent/ES2107624T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCESO DE GLICOSILACION ESTEREOSELECTIVA PARA LA PREPARACION DE FLUORONUCLEOSIDOS CON (BETA) ANOMEROS MEDIANTE EL DESPLAZAMIENTO DE SN2 DE UN GRUPO SULFONILOXI ANOMERICO DE UN FLUOCARBOHIDRATO ENRIQUECIDO CON UN ANOMERO CON UNA NUCLEOBASE.
ES93304817T 1992-06-22 1993-06-21 Procedimiento de glucosilacion estereoselectivo. Expired - Lifetime ES2107624T3 (es)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US90230292A 1992-06-22 1992-06-22
US90215092A 1992-06-22 1992-06-22
US90213592A 1992-06-22 1992-06-22
US90211292A 1992-06-22 1992-06-22
US90231392A 1992-06-22 1992-06-22
US07/902,312 US5371210A (en) 1992-06-22 1992-06-22 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US4430993A 1993-04-07 1993-04-07
US4431593A 1993-04-07 1993-04-07
US08/044,996 US5821357A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US08/044,343 US5401838A (en) 1992-06-22 1993-04-07 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US08/044,312 US5426183A (en) 1992-06-22 1993-04-07 Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US08/044,345 US5594124A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof

Publications (1)

Publication Number Publication Date
ES2107624T3 true ES2107624T3 (es) 1997-12-01

Family

ID=27583678

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93304817T Expired - Lifetime ES2107624T3 (es) 1992-06-22 1993-06-21 Procedimiento de glucosilacion estereoselectivo.

Country Status (20)

Country Link
EP (1) EP0577303B1 (es)
JP (1) JP3313191B2 (es)
KR (1) KR100252452B1 (es)
AT (1) ATE158799T1 (es)
BR (1) BR9302434A (es)
CA (1) CA2098881C (es)
CY (1) CY2067A (es)
DE (1) DE69314239C5 (es)
DK (1) DK0577303T3 (es)
ES (1) ES2107624T3 (es)
FI (1) FI108643B (es)
GR (1) GR3025689T3 (es)
HU (2) HU223837B1 (es)
IL (1) IL106071A (es)
MX (1) MX9303707A (es)
MY (1) MY115775A (es)
NO (1) NO180235B3 (es)
NZ (1) NZ247939A (es)
PL (1) PL172348B1 (es)
UA (1) UA41261C2 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
CA2239891A1 (en) 1995-12-13 1997-06-19 John Ashley Weigel .alpha., .alpha.-difluoro-.beta.-hydroxy thiol esters and their synthesis
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
ATE332910T1 (de) 2000-02-18 2006-08-15 Southern Res Inst Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
DE60226447D1 (de) * 2001-08-02 2008-06-19 Ilex Oncology Inc Verfahren zur herstellung von purinnukleosiden
DK1465615T3 (da) 2002-01-15 2012-11-12 Dartmouth College Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
US7265096B2 (en) 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
CN100384862C (zh) 2003-05-22 2008-04-30 独立行政法人科学技术振兴机构 α-选择性糖基化反应方法
WO2006070985A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
JP2008531680A (ja) * 2005-03-04 2008-08-14 ダブール・ファーマ・リミテッド βアノマーが富化された２１−デオキシ−２１，２１−ジフルオロ−Ｄ−リボフラノシルヌクレオシドの調製のための中間体と方法
CA2610283C (en) * 2005-06-03 2011-08-30 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-diflouro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
PL2252283T3 (pl) 2008-01-11 2019-09-30 Reata Pharmaceuticals, Inc. Syntetyczne triterpenoidy i sposoby zastosowania w leczeniu choroby
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
CN102164941B (zh) 2008-04-18 2015-05-27 里亚塔医药公司 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物
RS55631B1 (sr) 2008-04-18 2017-06-30 Reata Pharmaceuticals Inc Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline
WO2009129546A1 (en) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
CA2721665C (en) 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
HRP20181187T1 (hr) 2012-04-04 2018-09-21 Halozyme, Inc. Kombinirana terapija s hijaluronidazom i taksanom koji ciljano djeluje na tumor
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
CA2906284A1 (en) * 2013-03-15 2014-09-18 Epigenetics Pharma Llc Fluorinated pyrimidine analogs and methods of use thereof
CN110831605A (zh) 2017-04-26 2020-02-21 托马斯·I.·卡尔曼 多靶标的核苷衍生物
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
CA1324128C (en) * 1987-08-28 1993-11-09 Ta-Sen Chou 2', 2'-difluoronucleosides
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
EP0523110A1 (en) * 1990-04-04 1993-01-20 Nycomed Imaging As Nucleoside derivatives
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Also Published As

Publication number Publication date
GR3025689T3 (en) 1998-03-31
HU9301822D0 (en) 1993-09-28
HU0201196D0 (es) 2002-06-29
NO932288A (no) 1993-12-23
FI108643B (fi) 2002-02-28
HUT64358A (en) 1993-12-28
KR100252452B1 (en) 2000-04-15
NO180235B3 (no) 2007-10-01
CA2098881A1 (en) 1993-12-23
NO932288D0 (no) 1993-06-21
NZ247939A (en) 1996-02-27
CA2098881C (en) 2005-06-07
DE69314239T2 (de) 1998-02-19
ATE158799T1 (de) 1997-10-15
FI932869A0 (fi) 1993-06-21
MX9303707A (es) 1994-06-30
UA41261C2 (uk) 2001-09-17
IL106071A (en) 2006-08-20
DK0577303T3 (da) 1997-10-27
NO180235B (no) 1996-12-02
NO180235C (no) 1997-03-12
KR940005658A (ko) 1994-03-22
PL172348B1 (pl) 1997-09-30
CY2067A (en) 1993-06-21
IL106071A0 (en) 1993-10-20
PL299415A1 (en) 1994-03-07
DE69314239D1 (de) 1997-11-06
FI932869L (fi) 1993-12-23
DE69314239C5 (de) 2012-11-29
JPH06157570A (ja) 1994-06-03
EP0577303A1 (en) 1994-01-05
BR9302434A (pt) 1994-02-16
HU223837B1 (hu) 2005-02-28
EP0577303B1 (en) 1997-10-01
MY115775A (en) 2003-09-30
JP3313191B2 (ja) 2002-08-12

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