CZ117294A3 - Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised - Google Patents

Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised Download PDF

Info

Publication number
CZ117294A3
CZ117294A3 CZ941172A CZ117294A CZ117294A3 CZ 117294 A3 CZ117294 A3 CZ 117294A3 CZ 941172 A CZ941172 A CZ 941172A CZ 117294 A CZ117294 A CZ 117294A CZ 117294 A3 CZ117294 A3 CZ 117294A3
Authority
CZ
Czechia
Prior art keywords
group
carbon atoms
straight
branched
different
Prior art date
Application number
CZ941172A
Other languages
Czech (cs)
English (en)
Inventor
Peter Dr Fey
Walter Dr Hubsch
Jurgen Dr Dressel
Rudolf Dr Hanko
Thomas Dr Kramer
Ulrich Dr Muller
Matthias Dr Muller-Gliemann
Martin Dr Beuck
Hilmar Dr Bischoff
Stefan Dr Wohlfeil
Dirk Dr Denzer
Stanislav Prof Dr Kazda
Johannes-Peter Dr Stasch
Andreas Dr Knorr
Siegfried Dr Zaiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CZ117294A3 publication Critical patent/CZ117294A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CZ941172A 1993-05-13 1994-05-12 Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised CZ117294A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4316077A DE4316077A1 (de) 1993-05-13 1993-05-13 Substituierte Mono- und Bihydridylmethylpyridone

Publications (1)

Publication Number Publication Date
CZ117294A3 true CZ117294A3 (en) 1994-11-16

Family

ID=6488035

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ941172A CZ117294A3 (en) 1993-05-13 1994-05-12 Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised

Country Status (21)

Country Link
US (1) US5407948A (2)
EP (1) EP0624583B1 (2)
JP (1) JPH06329669A (2)
CN (1) CN1102648A (2)
AT (1) ATE155782T1 (2)
AU (1) AU672679B2 (2)
CA (1) CA2123243A1 (2)
CZ (1) CZ117294A3 (2)
DE (2) DE4316077A1 (2)
DK (1) DK0624583T3 (2)
ES (1) ES2105408T3 (2)
FI (1) FI942160L (2)
GR (1) GR3024465T3 (2)
HU (1) HUT70485A (2)
IL (1) IL109604A0 (2)
NO (1) NO941770L (2)
NZ (1) NZ260490A (2)
PH (1) PH30908A (2)
SK (1) SK55694A3 (2)
TW (1) TW245718B (2)
ZA (1) ZA943246B (2)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
KR100581199B1 (ko) 1998-06-19 2006-05-17 카이론 코포레이션 글리코겐 신타제 키나제 3의 억제제
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
WO2003059884A1 (en) * 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
RS52392B (sr) * 2002-02-14 2013-02-28 Pharmacia Corporation Supstituisani piridinoni kao modulatori p38 map kinaze
US6930117B2 (en) * 2002-11-09 2005-08-16 The Procter & Gamble Company N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
US6946479B2 (en) * 2002-11-09 2005-09-20 The Procter & Gamble Company N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
EP1919905B1 (en) * 2005-08-29 2011-02-23 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-recptor tyrosine kinases
WO2007027594A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
JP2009506123A (ja) 2005-08-29 2009-02-12 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
US8722894B2 (en) * 2007-09-14 2014-05-13 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
US8252937B2 (en) 2007-09-14 2012-08-28 Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
PL2203439T3 (pl) 2007-09-14 2011-06-30 Addex Pharmaceuticals Sa 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony
RU2492170C9 (ru) * 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
RU2517181C2 (ru) 2008-10-16 2014-05-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY153912A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
EP3698794A1 (en) * 2009-11-06 2020-08-26 Aerpio Therapeutics, Inc. Compositions and methods for treating colitis
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20220049612A (ko) 2014-01-21 2022-04-21 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
HUE053734T2 (hu) 2014-01-21 2021-07-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk
JP2024506858A (ja) 2021-02-02 2024-02-15 リミナル・バイオサイエンシーズ・リミテッド Ｇｐｒ８４アンタゴニストおよびその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5196537A (en) * 1991-03-21 1993-03-23 G. D. Searle & Co. 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
US5128327A (en) * 1991-03-25 1992-07-07 Merck & Co., Inc. Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle
US5164403A (en) * 1991-04-05 1992-11-17 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
US5155117A (en) * 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
US5332750A (en) * 1991-09-04 1994-07-26 Merck Patent Gesellschaft Mit Beschrankter Haftung 1,2-dihydro-2-oxopyridines
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
ES2105408T3 (es) 1997-10-16
FI942160A7 (fi) 1994-11-14
JPH06329669A (ja) 1994-11-29
HU9401417D0 (en) 1994-08-29
SK55694A3 (en) 1995-02-08
DE4316077A1 (de) 1994-11-17
DE59403427D1 (de) 1997-08-28
HUT70485A (en) 1995-10-30
AU6056194A (en) 1994-11-17
NZ260490A (en) 1995-12-21
ZA943246B (en) 1995-01-18
IL109604A0 (en) 1994-08-26
CA2123243A1 (en) 1994-11-14
PH30908A (en) 1997-12-23
EP0624583B1 (de) 1997-07-23
FI942160L (fi) 1994-11-14
US5407948A (en) 1995-04-18
TW245718B (2) 1995-04-21
NO941770D0 (no) 1994-05-11
NO941770L (no) 1994-11-14
CN1102648A (zh) 1995-05-17
GR3024465T3 (en) 1997-11-28
AU672679B2 (en) 1996-10-10
EP0624583A1 (de) 1994-11-17
DK0624583T3 (da) 1998-03-02
FI942160A0 (fi) 1994-05-10
ATE155782T1 (de) 1997-08-15

Similar Documents

Publication Publication Date Title
CZ117294A3 (en) Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised
CZ15793A3 (en) Sulfonylbenzyl-substituted pyridones
CZ289096B6 (cs) Heterocyklicky substituované deriváty kyseliny fenyl-cyklohexankarboxylové, způsob jejich výroby, jejich pouľití a farmaceutický prostředek tyto látky obsahující
CZ72393A3 (en) Sulfonylbenzyl-substituted benzopyridones and pyridopyridones
CZ29793A3 (en) Phenylacetic acid substituted amides
CZ297692A3 (en) Substituted derivatives of imidazolyl-propenoic acid
CZ283482B6 (cs) Trisubstituované bifenyly
CZ72193A3 (en) Biphenylmethyl substituted pyridones
CZ297792A3 (en) Cyclically substituted derivatives of imidazolyl-propenoic acid
CZ298892A3 (en) Derivatives of imidazolyl-propenoic acid
CZ29693A3 (en) Imidazolyl-substituted amides of phenylacetic acid
PT610698E (pt) Imidazo(4,5-b)piridinas e benzimidazoles substituidos como antagonistas de anguitensina ii
CZ62494A3 (en) Hetero-tricyclically substituted derivatives of phenyl-cyclohexanecarboxylic acid, process of their preparation, medicaments in which they are comprised, process for preparing such medicaments and their use
CZ71094A3 (en) Phenylglycinamides of heterocyclically substituted derivatives of phenylacetic acid, process of their preparation, medicaments in which said derivatives are comprised, process of their preparation and use
JPH0748369A (ja) 置換モノピリジルメチルおよびビピリジルメチル誘導体
CZ51693A3 (en) Propenoyl-imidazole derivatives
US5492923A (en) Substituted pyridines and 2-oxo-1,2-dihydropyridines
CZ117493A3 (en) Imidazolyl-substituted derivatives of phenylpropionic and cinnamic acids
CZ117393A3 (en) Imidazolyl-substituted cyclohexane derivatives
US5414003A (en) Pyridinylmethyl-substituted pyridines and pyridones
CZ221693A3 (en) Alkoxymethyl-substituted pyridonebiphenyls
CZ15993A3 (en) Sulfonylbenzyl-substituted derivatives of imidazolylpropenoic acid
CZ15893A3 (en) Sulfonylbenzyl-substituted imidazoles
CZ16093A3 (en) Sulfonylbenzyl-substituted imidazopyridines
SK27593A3 (en) Cycloalkyl and heterocyclyl substituted derivatives of imidazolylpropenoic acid