CZ135899A3 - Analogy vitamínu D - Google Patents

Analogy vitamínu D

Info

Publication number: CZ135899A3
Authority: CZ; Czechia
Prior art keywords: hydrogen; methylene; substituted; optionally; formula
Prior art date: 1996-10-30

Application number

CZ991358A

Other languages

English (en)

Other versions

CZ290933B6 (cs

Inventor

Martin John Calverley

Henrik Pedersen

Original Assignee

Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-30

Filing date

1997-10-27

Publication date

1999-07-14

1997-10-27 Application filed by Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) filed Critical Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab)

1999-07-14 Publication of CZ135899A3 publication Critical patent/CZ135899A3/cs

2002-11-13 Publication of CZ290933B6 publication Critical patent/CZ290933B6/cs

Links

229940046008 vitamin d Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical group C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Steroid Compounds (AREA)

CZ19991358A 1996-10-30 1997-10-27 Analogy vitaminu D, způsob jeho přípravy a pouľití a farmaceutický prostředek na jeho bázi CZ290933B6 (cs)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9622590.9A GB9622590D0 (en)	1996-10-30	1996-10-30	Chemical compounds

Publications (2)

Publication Number	Publication Date
CZ135899A3 true CZ135899A3 (cs)	1999-07-14
CZ290933B6 CZ290933B6 (cs)	2002-11-13

Family

ID=10802170

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ19991358A CZ290933B6 (cs)	1996-10-30	1997-10-27	Analogy vitaminu D, způsob jeho přípravy a pouľití a farmaceutický prostředek na jeho bázi

Country Status (20)

Country	Link
US (1)	US6310226B1 (cs)
EP (1)	EP0937038B1 (cs)
JP (1)	JP3907010B2 (cs)
KR (1)	KR100526644B1 (cs)
CN (1)	CN1107669C (cs)
AT (1)	ATE216361T1 (cs)
AU (1)	AU722659B2 (cs)
CA (1)	CA2266479C (cs)
CZ (1)	CZ290933B6 (cs)
DE (1)	DE69712086T2 (cs)
DK (1)	DK0937038T3 (cs)
ES (1)	ES2173425T3 (cs)
GB (1)	GB9622590D0 (cs)
HU (1)	HUP9904333A3 (cs)
NZ (1)	NZ334328A (cs)
PL (1)	PL192660B1 (cs)
PT (1)	PT937038E (cs)
RO (1)	RO120338B1 (cs)
RU (1)	RU2183622C2 (cs)
WO (1)	WO1998018759A1 (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2206981T3 (es) *	1997-07-17	2004-05-16	F.Hoffmann-La Roche Ag	Dihomo-seco-colestanos con dos enlaces insaturados en la cadena lateral.
US7351869B2 (en) *	2002-11-18	2008-04-01	Teva Pharmaceutical Industries Ltd	Crystallization method for purification of calcipotriene
CN1934078B (zh) *	2004-03-18	2011-07-06	利奥制药有限公司	维生素d类似物的立体选择性合成
CA2586679A1 (en)	2004-11-12	2006-05-18	Bioxell Spa	Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
WO2006113990A2 (en) *	2005-04-25	2006-11-02	Cytochroma Inc.	LOW-CALCEMIC 16,23-DIENE 25-OXIME ANALOGS OF 1α ,25-DIHYDROXY VITAMIN D3
US20080051375A1 (en) *	2006-08-25	2008-02-28	Auerbach Alan H	Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
CA2838089A1 (en)	2006-08-25	2008-02-28	Cougar Biotechnology, Inc.	Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
US20080051380A1 (en) *	2006-08-25	2008-02-28	Auerbach Alan H	Methods and compositions for treating cancer
BRPI0715636A2 (pt) *	2006-08-29	2013-07-02	Teva Pharma	composiÇÕes farmacologicamente ativas estÁveis incluindo compostos contendo vitamina d e corticosteràide com compatibilidade para ph baixo
SG173119A1 (en)	2009-01-27	2011-08-29	Berg Biosystems Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
WO2011002756A2 (en) *	2009-07-01	2011-01-06	Vitamin Derivatives, Inc.	Vitamin d compounds and methods for preparing same
MX366076B (es)	2009-08-14	2019-06-27	Berg Llc	Vitamina d3 y analogos de la misma para tratar alopecia.
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
WO2018023017A1 (en)	2016-07-29	2018-02-01	Janssen Pharmaceutica Nv	Methods of treating prostate cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8914963D0 (en) *	1989-06-29	1989-08-23	Leo Pharm Prod Ltd	Chemical compounds
US5260290A (en) *	1990-02-14	1993-11-09	Wisconsin Alumni Research Foundation	Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
GB9017890D0 (en) *	1990-08-15	1990-09-26	Leo Pharm Prod Ltd	Chemical compounds i
GB9206648D0 (en) *	1992-03-26	1992-05-06	Leo Pharm Prod Ltd	Chemical compounds
GB9223061D0 (en) *	1992-11-04	1992-12-16	Leo Pharm Prod Ltd	Chemical compounds
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
US5552392A (en) *	1993-11-03	1996-09-03	Wisconsin Alumni Research Foundation	Method of treating hypoparathyroidism with (20S) vitamin D compounds
JP3228488B2 (ja) *	1993-12-24	2001-11-12	株式会社クラレ	２０−エピステロイド誘導体およびその製造方法
JPH0888281A (ja) *	1994-09-19	1996-04-02	Fujitsu Ltd	半導体装置
IL118156A (en) *	1995-05-09	2001-08-26	Duphar Int Res	Vitamin d compounds, their preparation and pharmaceutical compositions containing them

1996
- 1996-10-30 GB GBGB9622590.9A patent/GB9622590D0/en active Pending
1997
- 1997-10-27 EP EP97910261A patent/EP0937038B1/en not_active Expired - Lifetime
- 1997-10-27 DE DE69712086T patent/DE69712086T2/de not_active Expired - Lifetime
- 1997-10-27 CN CN97198407A patent/CN1107669C/zh not_active Expired - Lifetime
- 1997-10-27 HU HU9904333A patent/HUP9904333A3/hu unknown
- 1997-10-27 CA CA002266479A patent/CA2266479C/en not_active Expired - Lifetime
- 1997-10-27 RO RO99-00325A patent/RO120338B1/ro unknown
- 1997-10-27 NZ NZ334328A patent/NZ334328A/xx not_active IP Right Cessation
- 1997-10-27 PT PT97910261T patent/PT937038E/pt unknown
- 1997-10-27 WO PCT/DK1997/000472 patent/WO1998018759A1/en not_active Ceased
- 1997-10-27 US US09/297,387 patent/US6310226B1/en not_active Expired - Lifetime
- 1997-10-27 DK DK97910261T patent/DK0937038T3/da active
- 1997-10-27 KR KR10-1999-7002315A patent/KR100526644B1/ko not_active Expired - Lifetime
- 1997-10-27 AT AT97910261T patent/ATE216361T1/de active
- 1997-10-27 AU AU47717/97A patent/AU722659B2/en not_active Expired
- 1997-10-27 JP JP51993198A patent/JP3907010B2/ja not_active Expired - Lifetime
- 1997-10-27 RU RU99111777/04A patent/RU2183622C2/ru active
- 1997-10-27 ES ES97910261T patent/ES2173425T3/es not_active Expired - Lifetime
- 1997-10-27 PL PL333068A patent/PL192660B1/pl unknown
- 1997-10-27 CZ CZ19991358A patent/CZ290933B6/cs not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3907010B2 (ja)	2007-04-18
PT937038E (pt)	2002-09-30
WO1998018759A1 (en)	1998-05-07
KR100526644B1 (ko)	2005-11-08
HK1022298A1 (en)	2000-08-04
DE69712086T2 (de)	2002-11-14
HUP9904333A3 (en)	2001-06-28
CZ290933B6 (cs)	2002-11-13
HUP9904333A2 (hu)	2000-06-28
DE69712086D1 (de)	2002-05-23
AU722659B2 (en)	2000-08-10
NZ334328A (en)	2000-09-29
RU2183622C2 (ru)	2002-06-20
CA2266479A1 (en)	1998-05-07
CN1107669C (zh)	2003-05-07
ATE216361T1 (de)	2002-05-15
EP0937038A1 (en)	1999-08-25
RO120338B1 (ro)	2005-12-30
DK0937038T3 (da)	2002-07-15
US6310226B1 (en)	2001-10-30
PL333068A1 (en)	1999-11-08
AU4771797A (en)	1998-05-22
ES2173425T3 (es)	2002-10-16
PL192660B1 (pl)	2006-11-30
EP0937038B1 (en)	2002-04-17
GB9622590D0 (en)	1997-01-08
KR20000036233A (ko)	2000-06-26
CA2266479C (en)	2008-09-23
CN1232448A (zh)	1999-10-20
JP2001503403A (ja)	2001-03-13

Legal Events

Date	Code	Title	Description
2000-06-30	PD00	Pending as of 2000-06-30 in czech republic
2017-11-08	MK4A	Patent expired	Effective date: 20171027

Publication	Publication Date	Title
HU9402484D0 (en)	1994-11-28	Vitamin d analogues
PT937038E (pt)	2002-09-30	Analogos de vitamina d
CA2078555A1 (en)	1992-02-16	Novel vitamin d analogues
EP0633878A1 (en)	1995-01-18	NEW VITAMIN D ANALOGS
DE69409811D1 (de)	1998-05-28	Neue vitamin d-derivate
PL339668A1 (en)	2001-01-02	Novel analogues of vitamin d
NZ332237A (en)	2000-07-28	Vitamin D analogues
AU7691396A (en)	1997-06-27	Vitamin d analogues
DK0662953T3 (da)	1997-10-13	Nye D-vitaminanaloger
PT944592E (pt)	2005-04-29	Derivados de vitamina d3
SE8803143L (sv)	1990-03-08	Alternativa energisubstrat
CA2222785A1 (en)	1997-06-12	Vitamin d analogues