CZ20003431A3 - Dihydro-benzo(1,4)oxazines and tetrahydroquinoxalines, their use and pharmaceutical preparation in which these compounds are comprised - Google Patents

Abstract

Physiologically active compounds of formula (I) wherein R1 is R3-Z3-, R3-L2-R4-Z3-, R3-L3-Ar'-L4-Z3-, R3-L3-Ar'-L2-R4 -Z3-, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; A1 represents an alkylene bond containing 2 to 3 carbon atoms optionally substituted; L 1 represents a direct bond, an alkenylene group, an alkylene group, an alkynylene group, a cycloalkenylene group, a cycloalkylene group, a heteroaryldiyl group, a heterocycloalkylene group, or an arylene bond, each of which is optionally substituted; Z 1 is NR 17 or O; Y represents a carboxy group, or the corresponding N-oxides and their prodrugs, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N-oxides and prodrugs. These compounds are useful for their pharmaceutical properties, in particular their ability to regulate the interaction of VCAM-1 and fibronectin with VLA-4 (α4βί).

Description

Dihydro-benzo (1,4) oxazines and tetrahydrochirioxalines, their use and pharmaceutical composition containing these compounds or compounds.

Field of the invention

The invention relates to aza-bicyclic compounds, in particular dihydro-benzo (1,4-oxazines and tetrahydroquinoxalines), to pharmaceutical compositions containing these compounds and to their pharmaceutical use in the treatment of diseases which can be modulated by inhibiting cell adhesion.

BACKGROUND OF THE INVENTION

Cell adhesion is the process by which cells connect to one another, migrate to a specific target, or settle in extracellular matter. Many cell-cell and cell-extracellular matrix interactions are mediated by protein ligands (e.g., fibronectin, VCAM-1 and vitronectin) and their integrin receptors (e.g., α5β1 (VLA-5), α4β1 (VLA-4), and dVp3). Recent studies have shown that these interactions play an important role in many physiological (such as embryo development and wound healing) and pathological conditions (such as tumor cell invasion and metastasis, inflammation, atherosclerosis, and autoimmune diseases).

Many proteins serve as ligands for integrin receptors. In general, proteins recognized by integrins fall into one of three groups: extracellular matter proteins, plasma proteins, and cell surface proteins. Extracellular matrix proteins such as collagen, fibronectin, fibrinogen, laminin, thrombospondin and vitronectin bind to a variety of integrins. Many of these adhesive proteins also circulate in plasma and bind to activated blood cells. Other plasma components that are integrin ligands include fibrinogen and factor X. Cell-bound ligands for certain integrins also include cell-bound C3bi complement and certain transmembrane proteins, such as an Ig-like cell adhesion molecule (ICAM-1,2, 3) and a vascular cell adhesion molecule (VCAM-1), which are members of the parent Ig family.

Integrins are heterodimeric cell surface receptors that consist of two subunits called α and β. There are at least fifteen distinct α (α-α, α-L, α-Μ, α-Χ, α-IIb, α-V and α-Ε) subunits and at least seven distinct β (β1-β7) subunits. The integrin family may be further subdivided into groups based on β subunits, which may be associated with one or more α subunits.

The most widespread integrins belong to the βΐ family, also known as very late antigens (VLAs). The second group of integrins are leukocyte specific receptors and consist of one of three subunits and (α-L, α-Μ or α-Χ) coupled to the β2 protein. The third group of integrins are α-ΙΙύβ3 and α ~ νβ3 cytoadhesins.

In principle, the present invention relates to compositions that modulate the interaction of VCAM-1 ligand with its α4β1 integrin receptor (VLA-4), which is expressed on a number of hemopoietic cells and stable cell lines, including hemopoietic precursors, peripheral and cytotoxic T lymphocytes, B lymphocytes , monocytes, thymocytes and eosinophils.

Integrin α4β1 mediates both types of cell-cell and cell-extracellular matter interactions. Cells expressing α4β1 bind the carboxy-terminal cell binding domain (CS-1) of the extracellular mass of fibronectin, to the cytokine-inducible endothelial cell surface protein VCAM-1 and to each other, thereby promoting homotypic aggregation. VCAM-1 expression by endothelial cells is activated by pro-inflammatory cytokines such as INF-gamma, TNF-alpha, IL-1beta and IL-4.

Regulation of α4β1-mediated cellular adhesion is important in a number of physiological processes, including T cell proliferation, germ cell localization of B cells, and adhesion of activated T cells and eosinophils to endothelial cells. Evidence for the involvement of VLA-4 / VCAM-1 interactions in various disease processes such as melanoma cell division in metastases, synovial membrane infiltration by T lymphocytes in rheumatoid arthritis, autoimmune diabetes, colitis and leukocyte penetration of the blood-brain barrier in experimental autoimmune encephalomyelitis peripheral blood vessels, cardiovascular disease, and multiple sclerosis, have been accumulated in investigating the role of CS-1 (a fibronectin variable region to which α4β1 binds via the Leu-Asp-Val sequence), and VLA-4 or VCAM-1 specific antibodies on various in vitro and in vivo experimental models of inflammation. For example, in an experimental model of streptococcal cell wall arthritis in a rat, intravenous administration of CS-1 at the onset of arthritis suppressed both acute and chronic inflammation (Wahl, SM, et al., J. Clin. Invest., 94, 655-662, 1994) .

In an oxazalone-induced inflammation model (hypersensitivity reaction on contact) in mice, intravenous administration of anti-α4 specific monoclonal antibodies significantly inhibited (50-60% reduction in ear swelling) effector response (Chisholm, PL et al., J. Immunol., 23, 682-638 (1993). In the model · · · · · · · · · · · · · · · · · · · · · ·

allergic bronchoconstriction in sheep was blocked by HP1 / 2, an anti-α4 monoclonal antibody, administered intravenously or by aerosol, late response and development of airway hypersensitivity (Abraham, W.M., et al., J. Clin. Invest.,

93, 776-787, 1994).

A new class of aza-bicyclic compounds having valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with integrin VLA-4 (α4β1) has been found.

SUMMARY OF THE INVENTION

One aspect of the present invention are aza-bicyclic compounds of formula (I):

in which:

R 1 represents a group selected from (i) R ³ -Z ³ (ii) R ³ -L ² -R ⁴ -Z ³ (iii) R ³ -L ³ -Ar ¹ -L ⁴ -Z ³ (iv) ) R ³ -L ³ -Ar ¹ -L ² -R ⁴ -Z ³ -,

R ² is hydrogen, halogen, lower alkyl or lower alkoxy;

·· ·. . ..

_E represents an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an arylalkyl group, an arylalkenyl group, an arylalkinyl group, a cycloalkyl group, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkinyl, cycloalkenyl, cycloalkenylalkyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl heterocycloalkyl or heterocycloalkylalkyl;

R ⁴ represents an alkylene group, an alkenylene group or an alkynylene group;

r5 represents a hydrogen atom or a lower alkyl group;

r6 is hydrogen, alkyl, alkenyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl or heteroarylalkyl;

v>

R is hydrogen or lower alkyl;

r8 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl;

R 6 represents an alkyl group, an aryl group, a cycloalkyl group, a heteroaryl group or a heterocycloalkyl group or an alkyl group

substituted with aryl, acidic, cycloalkyl, heteroaryl, heterocycloalkyl, -S (O) _m R ³ , -C (= O) -NY ⁴ Y ³ or _NY ⁴ Y ⁵ ;

R -Ιθ represents a hydrogen atom, R ³ or an alkyl group substituted with an alkoxy group, a cycloalkyl group, a hydroxy group, a mercapto group, an alkylthio group or -NY ⁴ Y ⁵ ;

13,

R ^xx and R ^J independently of each other are selected from the group consisting of 2-2 amino acids, an acidic functional group, R, -C (= O) -R, or -C (= O) -NY ⁴ Y ³ , or an alkyl group substituted with R ³ , -NY ⁴ Y ⁵ , -NH-C (= O) -R ³ , -C (= O) -R ⁴ -NH 2, -C (= O) -Ar ¹ -NH 2 , -C (= O) -R ⁴ -CO ₂ H or -C (= O) -NY ⁴ Y ⁵ ;

or R ¹ and R ^1, or R ¹ and R ¹³ together with the atoms to which they are attached form a three to six membered heterocyclic ring,

9

R is C 1 -C 6 alkylene optionally substituted with R;

R ⁴ represents an alkyl group, an aryl group, an arylalkyl group, a cycloalkyl group, a cycloalkylalkyl group, a heteroaryl group, a heteroarylalkyl group, a heterocycloalkyl group or a heterocycloalkylalkyl group;

Ri? represents a hydrogen atom, R 6, -C (= O) -R 6, -C (= O) -OR ⁴ ', or -SO ₂ R 9;

Means an alkylene bond containing 2 to 3 carbon atoms, which is optionally substituted by one or more groups selected from the group consisting of alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, imino, oxo, thioxo, or alkyl substituted with -ZR ⁶ , -NY ⁴ Y ² , -CO ₂ R ^6, or -C -CCO-NYY;

Ar ⁴ represents an arylene group or a heteroaryldiyl group;

L ¹ is (i) a direct bond, (ii) an alkenylene group, an alkylene group, an alkynylene group, a cycloalkenylene group, a cycloalkylene group, a heteroaryldiyl group, a heterocycloalkylene group or an arylene bond, each optionally substituted with an acidic functional group; cyano, oxo, -S (O) _m R ⁹ , R ³ , -C (= O) -R ³ , -C (= O) -OR ³ , -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ R ⁹ , -NY ⁴ Y ⁵ or - [C (= O) -N (R ¹⁰ ) - C (R ⁵ ) (R ¹¹ )] - C (= O) -NY ⁴ Y ⁵ , or (b) an alkyl group substituted with an acidic functional group or -S (O) _m R ⁹ , -C (= O) -NY ⁴ Y ⁴ or -NY ⁴ Y ⁴ ;

(iii) - [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ )] _p - linkage, (iv) -Z ² -R ⁴² - linkage;

(v) -C (= O) -CH ₂ -C (= O) - linkage;

(vi) -R ¹² -Z ² -R ¹² - linkage, (vii) -C (r ⁵ ) (R ¹³ ) - [C (= O) -N (R ¹⁰ ) -C (R ¹¹ ) (R ¹¹ ) ] - connection or (viii) -L ⁶ -L ⁶ -L ² - connection,

means -NR ⁵ -C (= Z) -NR ⁵ -, -C (= Z) -NR ⁵ -, -C (= O) -,

-C (= Z) -O-, -NR ⁵ -C (= Z) -, -Z-, -SO-, -SO 2 -, -NR ⁵ -, -SO 2 -NR ⁵ -,

-NR ⁵ -SO ₂ -, -NR ⁵ -C (= O) -O-, -OC (= O) -, or -OC (= O) -NR ⁵ coupling,

L ⁵ represents a heteroaryldiyl group, a heterocycloalkylene group, -NR ⁵ -C (= Z) -NR ⁵ -,

-C (= Z) -NR ⁵ -, -C (= Z) -O-, -NR ⁵ -C (= Z) -, -Z-,

-S0-, -S0 ₂ -, -NR ⁵ -, -SO 2 NR ⁵ -, -NR ⁵ -SO 2, -NR ⁵ -C (= O) -O-,

-O-C (= O) -, or -O-C (= O) -NR ⁵ - linkage, represents a direct bond, an alkylene group, an alkenylene group or an alkynylene group;

And L ⁵ independently each represent a direct bond or an alkylene group, represents a cycloalkylene or heterocycloalkylene group,

Y stands for carboxy (or bioisosteric acid), γΐ. _and γζ _on mutual independently each represent hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl or heteroarylalkyl group, 1 to 9, or the group -NY Y may form a cyclic amine, and Y ⁵ each each independently represents a hydrogen atom, an alkenyl group, an alkyl group, an alkynyl group, an aryl group, a cycloalkenyl group, a cycloalkyl group, a heteroaryl group, a heterocycloalkyl group, or an alkyl group

substituted alkoxy, aryl, cyano, cycloalkyl, heteroaryl, heterocycloalkyl, hydroxy, η 7 oxo, -NY Y, or one or more -CO ₂ R or -C (= O) -NY ⁴ Y ² , or NY ⁴ Y ⁵ may form a 5- to 7-membered cyclic amine which (i) may be optionally substituted with one or more substituents selected from alkoxy, carboxamide, carboxy, hydroxy, oxo (or a 5-, 6-membered or 7-membered cyclic acetal derivative thereof )

R ⁹ ;

(ii) may also contain another heteroatom selected from the group consisting of O, S, SO ₂ , or NY 2;

(iii) may also be fused to other aryl, heteroaryl, heterocycloalkyl or eycloalkyl rings to form a bicyclic or tricyclic ring system, γ6 represents a hydrogen atom, an alkyl group, an aryl group, an arylalkyl group -C (= O) -R ⁴⁴ , - C (= O) -OR ¹⁴ or -SO ₂ R ¹⁴ ,

Z is an oxygen or sulfur atom,

17

Z ^x is NR or O;

Z ² is O, S (O) _n , NR ⁵ , SONR ⁵ , C (= O) NR ⁵ or C (= O);

Z ³ is C (= O), OC (= O), NR ⁵ C (= O), or SO ₂ ;

m is 1 or 2, n is zero or 1 or 2, and p is zero or 1 to 4, but excluding compounds in which an oxygen, nitrogen or sulfur atom is attached directly to a carbon-carbon multiple bond of an alkenylene or alkynylene and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N-oxides and prodrugs.

As used herein, the term compound of the invention and equivalent terms are those of formula (I) as described and defined hereinabove and include prodrugs protected by derivatives of these compounds of formula (I) containing one or more acidic compounds. functional groups and / or amino acid side chains, pharmaceutically acceptable salts and solvates, such as hydrates, where possible in the context. Similarly, the term intermediates, whether or not as such protected by the claims, include their salts and solvates where this is possible in the context. For the sake of clarity and clarity, individual cases where indicated in the context are indicated directly in the text, but these are merely illustrative and do not exclude other forms as far as possible in the context.

As used herein, certain terms are used in the description of the present invention, the meaning of which, unless otherwise specifically stated, is as follows.

The term patient refers to both a human individual and other mammals.

By acidic bioisoster is meant a group that is chemically and physically similar and exhibits substantially similar biological properties to the carboxy group (Lipinski, Annual Reports in Medicine! Chemistry, 1986, 21, p. 283 Bioisosterism In Drug Design, Yun, Hwahak Sekye, 1993, 33, pp. 576-579 Application of Bioisosterism To New Drug Design, Zhao, Huaxue Tongbao, 1995, pp. 34-38, Bioisosteric Replacement And Development Of Lead Compounds In Drug Design, Ab initio Electronic Distributions In Bioisosteres ). Examples of suitable acidic bioisosteres include: -C (= O) -NHOH-, -C (= O) -CH ₂ OH, -C (= O) -CH ₂ SH, -C (= O) -NH -CN, sulfo, phosphono, alkylsulfonylcarbamoyl, tetrazolyl, arylsulfonylcarbamoyl, heteroarylsulfonylcarbamoyl, N-methoxycarbamoyl,

3-hydroxy-3-cyclobutene-1,2-dione group,

3,5-dioxo-1,2,4-oxadiazolidinyl or heterocyclic phenols such as

3-hydroxyisoxazolyl and 3-hydroxy-1-methylpyrazolyl.

By acidic functional group is meant a group with acidic hydrogen. Corresponding protected derivatives are derivatives in which the acidic hydrogen atom is replaced by a suitable protecting group. Examples of suitable protecting groups include T. W. Greene and P.G.M. Wuts Protective Groups in Organic Chemistry John Wiley & Sons, 1991. Examples of acidic functional groups include the carboxyl group (and acidic bioisosteres), the hydroxy group,

mercapto and imidazole. Examples of protected derivatives include carboxylic acid esters (i.e., -CO ² R ¹⁴ ), hydroxy ethers (i.e. -OR ¹⁴ ), mercapto thioethers (i.e. -SR ¹⁴ ), and N-benzyl derivatives of imidazoles.

The term acyl group refers to the group H-CO- or alkyl-CO-, in which the alkyl group has the same meaning as defined herein.

The term acylamino means acyl--, wherein acyl has the same meaning as defined herein.

By alkenyl is meant an aliphatic hydrocarbon group containing a carbon-carbon double bond, which group may be straight or branched and contains about 2 to about 12 carbon atoms in the chain. Preferred alkenyl groups include groups having from 2 to about 12 carbon atoms in the chain and more preferably alkenyl groups having from about 2 to about 4 carbon atoms in the chain. Branched throughout is meant that one or more lower alkyl groups, such as methyl, ethyl or propyl, in this case linear alkenyl, are attached to the linear chain. Examples of alkenyl groups include ethenyl, propenyl, n-butenyl, i-butenyl, 3-methylbut-2-enyl, n-pentenyl, heptenyl, octenyl, cyclohexylbutenyl and decenyl.

The term alkenylene group refers to an aliphatic group.

A divalent radical derived from a straight or branched chain alkenyl group in which the alkenyl group has the same meaning as defined herein. Examples of alkenylene groups include vinylene and propylene.

The term alkoxy refers to an alkyl-O- group in which the alkyl group has the same meaning as defined herein. Examples of alkoxy include methoxy, ethoxy, n-propoxy, i-propoxy, n-butoxy and heptoxy.

The term alkoxycarbonyl means an alkyl-O-CO- group in which the alkyl group has the same meaning as previously defined. Examples of alkoxycarbonyl groups include methoxy and ethoxycarbonyl.

The term alkyl, unless otherwise specified, refers to an aliphatic hydrocarbon group which may be straight or branched chain containing from about 1 to about 15 carbon atoms in the chain, optionally substituted with alkoxy or one or more halogen atoms. A particular example of an alkyl group is an alkyl group having from about 1 to about 6 carbon atoms. The term lower alkyl refers to a group or part of a lower alkoxy group, a lower alkylthio group, a lower alkylsulfinyl group, or a lower alkylsulfonyl group, unless specifically specified, an aliphatic hydrocarbon group which may be straight or branched chain containing from about 1 to about 4 atoms of carbon in the chain. Examples of alkyl groups include methyl, ethyl, n-propyl, i-propyl, n-butyl

«» · · * 4 4 5

44 ··· 4 44 4

444 group, s-butyl group, ΐ-butyl group, n-pentyl group, 3-pentyl group, heptyl group, octyl group, nonyl group, decyl group a dodecyl group.

The term alkylene group refers to an aliphatic divalent radical derived from a straight or branched chain alkyl group in which the alkyl group has the same meaning as defined herein. Examples of alkylene groups include methylene, ethylene and trimethylene.

The term alkylenedioxy means an O-alkyl-O- group in which the alkyl group has the same meaning as defined herein. Examples of alkylenedioxy groups are methylenedioxy and ethylenedioxy.

The term alkylsulfinyl means an alkyl-SO- group in which the alkyl group has the same meaning as defined herein. Preferred alkylsulfinyl groups include those in which the alkyl group contains 1 to 4 carbon atoms.

The term alkylsulfonyl refers to the group alkyl-S0 ₂ - group in which the alkyl group is as defined herein. Preferred alkylsulfonyl groups include those in which the alkyl group contains 1 to 4 carbon atoms.

By &Alkylsulfonylcarbamoyl; means an alkyl-S0 ₂ -NH-C (= 0) - group in which the alkyl group is as defined herein. Preferred alkylsulfonyl groups include those in which the alkyl group contains 1 to 4 carbon atoms.

The term alkylthio is a mini-alkyl-S- group in which the alkyl group has the same meaning as defined herein. Examples of alkylthio groups include methylthio, ethylthio, isopropylthio and heptylthio.

By alkynyl is meant an aliphatic hydrocarbon group containing a carbon-carbon triple bond, which group may be straight or branched chain and contains about 2 to about 15 carbon atoms in the chain. Preferred alkynyl groups include groups having from 2 to about 12 carbon atoms in the chain, and more preferably an alkynyl group having from about 2 to about 4 carbon atoms in the chain. Examples of alkynyl groups include ethynyl, propynyl, n-butynyl, i-butynyl,

3-methylbut-2-ynyl and n-heptinyl.

By alkynylene is meant an aliphatic divalent radical derived from a straight or branched chain alkynyl group in which the alkynyl group has the same meaning as defined herein. Examples of alkynylene groups include ethynylene and propynylene.

By amino acid side chain is meant a substituent that is located on the carbon between amino and carboxy groups of α-amino acids. Examples of corresponding protected amino acid side chain derivatives can be found in T. W. Greene and P.G.M. Wuts

• · · · · · · · · ·

Protective Groups in Organic Chemistry, John Wiley & Sons, 1991.

The term aroyl group refers to an aryl-CO- group in which the aryl group has the same meaning as defined herein. Examples of aroyl groups include benzoyl and 1-naphthoyl and 2-naphthoyl.

The term aroylamino group means an aroyl-NH- group in which aroyl has the same meaning as defined herein.

The term aryl as a separate group or as part of a group means:

(i) an optionally substituted monocyclic or multicyclic aromatic carbocyclic moiety containing from about 6 to about 14 carbon atoms, such as phenyl or naphthyl, or (ii) an optionally substituted partially saturated multicyclic aromatic carbocyclic moiety wherein they are the aryl and cycloalkyl or cycloalkenyl moieties are condensed together to form a cyclic structure such as a tetrahydronaphthyl ring, an indenyl ring or an indanyl ring. Aryl groups may be substituted by one or more aryl group substituents, which may be the same or different, and include, for example, acyl group, acylamino group, alkoxy group, alkoxycarbonyl group, alkylenedioxy group, alkylsulfinyl group, alkylsulfonyl group, alkylthio group, aroyl group group, aroylamino group, aryl group, arylalkyloxy group, arylalkyloxycarbonyl group, ·

Arylalkylthio, aryloxy, aryloxycarbonyl, arylsulfinyl, arylsulfonyl, arylsulfonyl, arylthio, carboxy, cyano, halogen, heteroaroyl, heteroaryl, heteroarylalkyloxy, heteroarylamino, heteroaroylamino, heteroaroylamino, heteroarylamino, -, Y ^ Y ^ NCO group Y ^ Y ^ NSC ^ - Y ^ Y ^ N-alkylene-Z ⁴ - (in which the alkylene moiety contains 2 to 6 carbon atoms, and Z ⁴ is 0, NR ³ or S (O) _n ), alkylC (= O) -Y 4 N-, alkylSC 4 -Y 4 N-, or alkyl optionally substituted with aryl, heteroaryl, hydroxy or Υ Y N-.

The term "arylalkenyl" refers to an aryl-alkenyl group in which the aryl and alkenyl groups have the same meaning as defined herein. Preferred arylalkenyl groups contain a lower alkenyl moiety. Examples of arylalkenyl groups include styryl and phenylallyl.

The term "arylalkyl" refers to an aryl-alkyl group in which the aryl and alkyl groups have the same meaning as defined herein. Preferred arylalkyl groups also contain an alkyl moiety having 1 to 4 carbon atoms. Examples of arylalkyl groups include benzyl, 2-phenethyl and naphthalenomethyl.

The term "arylalkyloxy" refers to an arylalkyl-group in which the arylalkyl groups have the same meaning as defined herein. An example of such arylalkyloxy is benzyloxy

and 1-naphthalenmethoxy or 2-naphthalenmethoxy.

The term arylalkyloxycarbonyl means an arylalkyl-O-CO- group in which the arylalkyl groups have the same meaning as defined herein. An example of an arylalkyloxycarbonyl group is benzyloxycarbonyl.

The term "arylalkylthio" refers to an arylalkyl-S group in which the arylalkyl group has the same meaning as defined herein. An example of an arylalkylthio group is benzylthio.

The term "arylalkinyl" refers to an aryl-alkynyl group in which the aryl and alkynyl groups have the same meaning as defined herein. Examples of such arylalkynyl are phenylethynyl and 3-phenylbut-2-ynyl.

By arylene group is meant an optionally substituted divalent radical derived from an aryl group. Examples of arylene groups include an optionally substituted phenylene group, a naphthylene group, and an indanylene group. When Ar ¹ is an arylene group, this group may specifically represent an optionally substituted phenylene group. Suitable substituents include one or more aryl group substituents as defined above, in particular halogens, methyl or methoxy.

The term "aryloxy" refers to an aryl-O- group in which the aryl moiety has the same meaning as previously defined

in this text. Examples of aryloxy are optionally substituted phenoxy and naphthoxy.

The term aryloxycarbonyl means an aryl-O-C (= O) - group in which the aryl moiety has the same meaning as defined herein. Examples of aryloxycarbonyl include phenoxycarbonyl and naphthoxycarbonyl.

The term "arylsulfinyl" refers to an aryl-SO- group in which the aryl moiety has the same meaning as defined herein.

The term "arylsulfonyl" refers to an aryl-SO 2 - group in which the aryl moiety has the same meaning as defined herein.

The term "arylsulfonylcarbamoyl" refers to an aryl-SO ₂ -NH-C (= O) - group in which the aryl moiety has the same meaning as defined herein.

The term arylthio refers to an aryl-S- group in which the aryl moiety has the same meaning as defined herein. Examples of arylthio are phenylthio and naphthylthio.

The term azaheteroaryl refers to an aromatic carbocyclic moiety containing from about 5 to about 10 ring members, one of which ring members is nitrogen and the other ring members are selected from the group consisting of carbon, oxygen, sulfur, and nitrogen. Examples of such azaheteroaryl groups include pyridyl, pyrimidinyl, quinolinyl, isoquinolinyl,

a quinazolinyl group, an imidazolyl group and a benzimidazolyl group.

The term "azaheteroaryldiyl" refers to an optionally substituted divalent group derived from a heteroaryl group.

By cyclic amine is meant a 3- to 8-membered monocyclic cycloalkyl ring system in which one of the ring carbon atoms is replaced by nitrogen, and which (i) may optionally contain another heteroatom selected from a and O, S or NY (where Y is an atom) hydrogen, alkyl, arylalkyl and aryl) and (ii) may be fused to another aryl or heteroaryl ring to form a bicyclic ring system. Examples of such cyclic amines are pyrrolidine, piperidine, morpholinyl, piperazine, indoline and pyrindoline.

By cycloalkenyl is meant a non-aromatic monocyclic or multi-cyclic ring system containing at least one carbon-carbon double bond containing about 3 to about 10 carbon atoms. Examples of such monocyclic cycloalkenyl rings include cyclopentenyl, cyclohexenyl or cycloheptenyl.

The term cycloalkenylaalkyl means a cycloalkenyl-alkyl group in which the cycloalkenyl and alkyl moieties have the same meaning as previously defined.

in this text. Examples of cycloalkenylalkyl groups are cyclopentenylmethyl, cyclohexenylmethyl or cycloheptenylmethyl.

φφφ

The term cycloalkenylene refers to a divalent radical derived from an unsaturated monocyclic hydrocarbon containing from about 3 to about 10 carbon atoms by removing the hydrogen atom from each of the two different ring carbon atoms. Examples of cycloalkenylene groups are cyclopentenylene and cyclohexenylene.

The term cycloalkyl refers to a saturated monocyclic or bicyclic ring system containing from about 3 to about 10 carbon atoms, optionally substituted with an oxo group. Exemplary monocyclic cycloalkyl rings include C 3 -C 8 cycloalkyl rings such as cyclopropyl, cyclopentyl, cyclohexyl and cycloheptyl.

The term cycloalkylalkenyl refers to a cycloalkyl-alkenyl group in which the cycloalkyl moiety and the alkenyl moiety have the same meaning as defined herein. Examples of monocyclic cycloalkylalkenyl groups include cyclopentylvinylene and cyclohexylvinylene.

The term cycloalkylalkyl refers to a cycloalkyl-alkyl group in which the cycloalkyl moiety and the alkyl moiety have the same meaning as defined herein. Exemplary monocyclic cycloalkylalkyl groups include cyclopentylmethyl, cyclopropylmethyl, cyclohexylmethyl and cycloheptylmethyl.

The term cycloalkylalkynyl refers to a cycloalkyl-alkynyl group in which the cycloalkyl and alkynyl moieties have the same meaning as defined herein. Examples of monocyclic cycloalkylalkynyl groups include cyclopropylethynyl, cyclopentylethynyl and cyclohexylethynyl.

By cycloalkylene is meant a divalent radical derived from a saturated monocyclic hydrocarbon containing from about 3 to about 10 carbon atoms, which is obtained by removing a hydrogen atom from each of the two different ring carbon atoms. Examples of such cycloalkylene groups include cyclopentylene group and cyclohexylene group.

The term halo or halogen means a fluorine, chlorine, bromine or iodine atom. It is preferably fluorine or chlorine.

The term heteroaroyl refers to a heteroaryl-C (= O) - group in which the heteroaryl group has the same meaning as defined herein. An example of a heteroaroyl group is pyridylcarbonyl.

The term heteroaroylamino means a heteroaroyl-NH- group in which the heteroaryl moiety has the same meaning as defined herein.

The term heteroaryl means both a group and a portion of a group which means:

(i) an optionally substituted aromatic monocyclic or multi-cyclic organic moiety comprising about 5 to about 10 ring members wherein one or more of the ring members is (or is) a member (s) other than a carbon atom, such as a nitrogen atom, oxygen or sulfur (exemplified by benzimidazolyl, benzthiazolyl, furyl, imidazolyl, indolyl, indalizinyl, isoxazolyl, isoquinolinyl, isothiazolyl, oxadiazolyl, pyrazinyl, pyridazinyl, pyrazolyl, pyrazolyl pyridyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolinyl, 1,3,4-thiadiazolyl, thiazolyl, thienyl and triazolyl, which may optionally be substituted by one or more aryl group substituents as defined above, (ii) an optionally substituted partially saturated multicyclic heterocarbocyclic moiety in which the heteroaryl and cycloalkyl or cycloalkenyl groups are fused together to form a cyclic structure (an example of which is pyrindanyl). Optional substituents are one or more aryl group substituents as defined above.

The term heteroarylalkenyl means a heteroaryl-alkenyl group in which the heteroaryl and alkenyl moieties have the same meaning as previously defined. Preferred heteroarylalkenyl groups contain a lower alkenyl group. Examples of heteroarylalkenyl groups include pyridylethenyl and pyridylallyl.

The term heteroarylalkyl refers to a heteroaryl-alkyl group in which the heteroaryl moiety and the alkyl moiety have the same meanings as defined above. Preferred heteroarylalkyl groups also contain an alkyl group having 1 to 4 carbon atoms. Exemplary heteroarylalkyl groups include pyridylmethyl.

The term heteroarylalkoxy refers to a heteroarylalkyl-O- group in which the heteroarylalkyl group has the same meaning as defined herein. An example of a heteroaryloxy group is an optionally substituted pyridylmethoxy group.

The term heteroarylalkinyl means a heteroaryl-alkynyl group in which the heteroaryl and alkynyl groups have the same meaning as defined herein. Exemplary heteroarylalkenyl groups include pyridylethynyl a

3-pyridylbut-2-ynyl.

By a heteroaryldiyl group is meant a divalent radical derived from an aromatic monocyclic or multicyclic organic moiety containing about 5 to about 10 ring members in which one or more of the ring members are (or is) elements (or an element) other than a carbon atom, for example, nitrogen, oxygen or sulfur, and optionally is substituted with one or more aryl substituents

groups as defined herein. When Ar ¹ is an optionally substituted heteroaryldiyl group, the group may be an optionally substituted azaheteroaryldiyl group.

The term heteroaryloxy refers to a heteroaryl-OS group in which the heteroaryl group has the same meaning as previously defined. An example of a heteroaryloxy group is an optionally substituted pyridyloxy group.

The term heteroarylsulfonylcarbamoyl refers to a heteroaryl-SO2-NH-C (= O) - group in which the heteroaryl group has the same meaning as previously defined.

The term heterocycloalkyl means:

(i) a cycloalkyl group of about 3 to about 7 ring members which contains one or more -2 heteroatoms selected from oxygen, sulfur or NY and which may be optionally substituted by oxo; (ii) optionally substituted partially saturated multicyclic a heterocarbocyclic moiety in which an aryl ring (or heteroaryl ring) and a heterocycloalkyl group are fused together to form a cyclic structure (examples include chromanyl, dihydrobenzofuranyl, indolinyl and pyrindolinyl).

The term heterocycloalkylalkyl means a heterocycloalkyl-alkyl group in which the heterocycloalkyl moiety and the alkyl moiety have the same meaning as previously defined.

Tff tff

The term heterocycloalkylene refers to a divalent radical derived from a saturated monocyclic hydrocarbon containing from about 5 to about 7 carbon atoms and containing one or more heteroatoms selected from the group consisting of oxygen, sulfur and NY and optionally substituted by an oxo group, which residue is obtained by removal a hydrogen atom from each of the two different ring carbon atoms, or when NY is NH by removing a hydrogen atom from one ring carbon atom and a hydrogen atom from that NH group, or if the ring contains two NY heteroatoms and NY is NH by removing the hydrogen atom from both nitrogen atoms.

When L ⁴ is a heterocycloalkylene group, this group may in particular represent a divalent radical derived from pyrrolidine, in particular 3,4-pyrrolidinediyl.

By prodrug is meant a compound that is convertible in vivo by metabolic means (such as by hydrolysis) to a compound of Formula I, including N-oxides thereof. For example, an ester of a compound of formula I containing a hydroxy group can be converted by hydrolysis in vivo to the parent molecule. Alternatively, an ester of a compound of Formula I containing a carboxy group may be convertible by hydrolysis in vivo to a parent molecule.

Suitable hydroxy-containing esters of the compounds of formula (I) include, for example, acetates, citrates, lactates, tartrates, malonates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-p-hydroxynaphthoates, gentisates, isothionates, di-p-toluoyltartrate , methanesulfonates, ethanesulfonates, benzenesulfonates, p-toluenesulfonates, cyclohexylsulfamates, and quinates.

Suitable carboxy-containing esters of the compound of formula (I) include, for example, those described in F.J. Leinweber, Drug Metab. Res., 1987, 18, 379.

Suitable esters of the compounds of formula I containing both a carboxy group and a hydroxy group in the-části-Υ- moiety include lactones formed by the loss of water between said carboxy group and the hydroxy group. Examples of lactones include caprolactones and butyrolactones.

A particularly suitable group of hydroxyl-containing esters of the compounds of formula (I) may be obtained from acid moieties selected from Bundgaard et al., J. Med. Chem., 1989, 32, pp. 2503-2507, which may include substituted (aminomethyl) benzoates, for example dialkylaminomethylbenzoates, in which two alkyl groups may be joined together and / or interrupted by an oxygen atom or optionally substituted a nitrogen atom, such as an alkylated nitrogen atom, especially (morpholinomethyl) benzoates, such as e.g.

3- (morpholinomethyl) benzoates or

4- (morpholinomethyl) benzoates a

4- (alkylpiperazin-1-yl) benzoates, such as, for example

3- (4-alkylpiperazin-1-yl) benzoates;

4- (4-alkylpiperazin-1-yl) benzoates.

Where the compounds of the present invention contain a carboxy group or a sufficiently acidic bioisoster, base addition salts can be readily obtained,

Φ ·

Wherein these base addition salts represent a suitable form for use and, in practice, the salt form of the compound in itself means the same as the free acid forms. Bases which can be used to prepare these base addition salts include those which, when combined with the free acid, provide pharmaceutically acceptable salts, i.e. salts whose cations are nontoxic to the patient in pharmaceutically administered formulations. doses of these salts, so that the beneficial inhibitory effect inherent in the free base is not diminished by the side effects that occur due to the presence of cations. Pharmaceutically acceptable salts, including those derived from the alkali or alkaline earth metals within the scope of the present invention, include those derived from the following bases: sodium hydride, sodium hydroxide, potassium hydroxide, calcium hydroxide, hydroxide aluminum, lithium hydroxide, magnesium hydroxide, zinc hydroxide, ammonia, ethylenediamine,

N-methylglucamine, lysine, arginine, ornithine, choline,

Ν, N'-dibenzylethylenediamine, chloroprocaine, diethanolamine, procaine, N-benzylphenethylamine, diethylamine, piperazine, tris (hydroxymethyl) aminomethane, tetramethylammonium hydroxide and the like.

Some of the compounds of the present invention are basic and are useful in the form of the free bases or in the form of pharmaceutically acceptable acid addition salts thereof.

Acid addition salts are a more convenient form for use, and in practice the use of these salts is the same as the use of the free base form. Between

• »· • * · • · · Iv • · 4 · • · 9 • • · 9 9 9 9 9 4 • · • · • • ·· ·· 49 944 t · •

The acids which can be used to prepare these acid addition salts preferably include those which, when combined with the free bases, provide pharmaceutically acceptable salts, i.e. salts whose cations are nontoxic to the patient at pharmaceutically administered doses of these salts, so that the beneficial inhibitory effect inherent in the free base is not diminished by the side effects that occur due to the presence of cations. While pharmaceutically acceptable salts of said basic compounds are preferred, all acid addition salts are used as sources of the free base forms, unless the specific salt per se is not only required as an intermediate, such as when the salt is obtained only for purification and identification, or when used as an intermediate in the preparation of a pharmaceutically acceptable salt by ion exchange procedures. Pharmaceutically acceptable salts, including those derived from mineral acids and organic acids within the scope of the present invention, include hydrohalides such as hydrochlorides and hydrobromides, sulfates, phosphates, nitrates, sulfamates, acetates, citrates, lactates, tartrates, malonates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-p-hydroxynaphthoates, gentisates, isethionates, di-p-toluoyltartrates, methanesulfonates, ethanesulfonates, benzenesulfonates, p-toluenesulfonates, cyclohexylsulfonates, cyclohexylsulfonates, cyclohexylsulfonates.

Salts of the compounds of the present invention are both suitable as such as active compounds and are useful for purification purposes, for example, to extend the solubility range between the salt and the parent compound, by-products and / or starting materials,

4 to 4 using methods well known in the art.

With respect to the compounds of formula (I) above, the following groups of compounds are particularly preferred:

3 3 3

In particular, R may be a group R -Z- in which it has the same meaning as defined above, in particular C (= O), and R ^ has the same meaning as defined above, in particular (i) an optionally substituted aryl group such as optionally substituted phenyl [preferred optional substituents are aryloxy, cyano, halogen (such as chlorine or fluorine), lower alkoxy (such as methoxy), lower alkyl (such as methyl), nitro and perfluoro-lower-alkyl (such as trifluoromethyl), (ii) optionally substituted heteroaryl such as isoquinolinyl, isoxazolyl, pyrazolopyrimidinyl, pyridyl, pyrimidinyl, quinolinyl, thiazolyl and triazolyl, each of which may be optionally substituted with one n or more aryl substituents as defined above [preferred optional substituents include alkyl-C (= O) -, aryl, cyano, halogens (such as chlorine or fluorine), lower alkoxy (such as methoxy) ), a lower alkyl group (such as a methyl group), a lower alkylsulfonyl group, a lower alkylthio group, a nitro group and a perfluoro-lower-alkyl group (such as a trifluoromethyl group) or (iii) an optionally substituted arylalkyl group in which the aryl group is optionally substituted with one or preferably two aryl group substituents (preferred optional substituents include halogens, hydroxy and methoxy).

R ^x may in particular be an R -C (= O) - group in which R ³ represents a substituted aryl group selected from 2-chlorophenyl,

5-chloro-2-cyanophenyl, 2-chloro-6-methylphenyl, 2,6-dichlorophenyl, 2,6-difluorophenyl, 4-fluoro-2-trifluoromethyl,

2-methyl-4-nitrophenyl, 2-methyl-5-nitrophenyl, 2-nitrophenyl, 3-nitrophenyl, 2-phenoxyphenyl or an optionally substituted heteroaryl group selected from quinolin-4-yl, isoquinoline A -2-yl group,

2,4-pyridin-3-yl,

2,6-dimethyl-4-trifluoromethylpyridin-3-yl;

A 4-trifluoromethylpyridin-3-yl group,

A 2-phenyl-4-methyl-1,2,3-triazol-5-yl group,

3,5-dimethylisoxazol-4-yl;

A 2,7-dimethylpyrazolo [1,5-a] pyrimidin-6-yl group,

A 2-isopropyl-4-methylthiazol-5-yl group,

4-trifluoromethylpyrimidin-5-yl, 4-hydroxybenzyl, 3-chloro-4-hydroxybenzyl,

3-fluoro-4-hydroxybenzyl and 4-hydroxy-3-methoxybenzyl.

it may also in particular be a group R ³ -L ³ -Ar ¹ -L ⁴ -Z ³ - in which

Z ³ has the same meaning as described above, in particular

C (= 0)

L ⁴ represents a straight or branched chain alkylene group having 1 to 6 carbon atoms, preferably

a straight chain alkylene group having 1 to 4 carbon atoms, such as a methylene group or an ethylene group, preferably a methylene group,

Ar * * represents an optionally substituted phenylene group, such as an optionally substituted m-phenylene group or a p-phenylene group, preferably an optionally substituted p-phenylene group, more preferably a 3-substituted p-phenylene group in which a substituent in the ortho-position to position the R 1 -C 1 - group, (preferred optional substituents include halogens, C 1 -C 4 alkyl groups, C 1 -C 4 alkoxy groups, C 1 -C 4 alkylthio groups, alkylsulfinyl groups C 1 -C 4 alkyl and C 1 -C 4 alkylsulfonyl, in particular suitable optional substituents are chlorine, methyl, ethyl, methoxy, methylthio, methylsulfinyl and methylsulfonyl), or Ar 1 represents an optionally substituted heteroaryldiyl group such as an optionally substituted azaheteroaryldiyl group (such as an optionally substituted pyridindiyl group, preferably a p-pyridindiyl group), wherein the optional substituents include, for example, a C 1 -C 4 alkyl group and a C 1 -C 4 alkoxy group, particularly methyl. and methoxy, particularly preferred is pyridine-2,5-diyl a and the group in which the R-L-group is adjacent to the pyridyl nitrogen atom, which group is substituted in the

A 4-position or a 6-position by a methyl or methoxy group,

ΦΦΦ

φ. φ represents the group -NH-C (= O) -NH-, and has the same meaning as above, in particular an optionally substituted aryl group (such as an optionally substituted phenyl group) or an optionally substituted heteroaryl group (such as an optionally substituted pyridyl group) The group is preferably 2-methyl (or methoxy) phenyl or 3-methyl (or methoxy) phenyl, more preferably 2-methylphenyl or 3-methyl-2-pyridyl.

In particular, the substituent R ⁴ may also be a group R ¹ -L ⁴ -Ar ⁴ -L ⁴ -Z ⁴ - in which:

7? has the same meaning as previously defined, in particular C (= O),

L ⁴ represents a straight-chain or branched alkylene group having 1 to 6 carbon atoms, in particular an alkylene group having 1 to 4 straight-chain carbon atoms, such as methylene or ethylene, preferably methylene,

Ar ⁴ stands for an eight- to ten-membered bicyclic system?

(i) the ring represents a 5- or 6-membered optionally substituted heterocycle, preferably a 5-membered heteroaryl ring, (ii) a ring means a 5- or 6-membered optionally substituted heterocycle, or an optionally substituted benzene ring, preferably a benzene ring, (iii) each the ring is optionally substituted with one or more aryl group substituents as defined above; (iv) the two rings are joined together by a carbon-carbon or carbon-nitrogen bond, which system is preferably optionally substituted by a benzoxazolyl group or an optionally substituted benzimidazolyl group, each [especially circle

optionally substituted with one or more aryl group substituents as defined above [examples of particular aryl group substituents include lower alkyl (such as methyl), lower alkoxy (such as methoxy), amino, halogens, hydroxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro or trifluoromethyl],

L is NR, especially NH, and * 3

R ^J has the same meaning as defined above, in particular an optionally substituted aryl group such as a 2-substituted phenyl group [examples of particular aryl group substituents include lower alkyl (such as methyl), lower alkoxy (such as for example methoxy), halogens (such as fluorine or chlorine) and Υ Y N- (such as dimethylamino)], and is preferably 2-methylphenyl.

In particular, R ^ may also be R ^ -L ^ -Ar--L ^ -Z - - in which:

has the same meaning as defined above, in particular means the group C (= O),

L ⁴ represents a straight or branched chain alkylene group having 1 to 6 carbon atoms, in particular a straight chain branched alkylene group having 1 to 4 carbon atoms, such as a methylene group or an ethylene group, preferably a methylene group,

Ar3 represents an optionally substituted phenylene group, such as an optionally substituted m-phenylene group or a p-phenylene group, preferably an optionally substituted p-phenylene group, more preferably a 3-substituted p-phenylene group. - a phenylene group in which the substituent is located in the ortho position by 3 relative to the location of the group R-L - (preferred optional substituents include chlorine, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, alkylthio) (C 1 -C 4 -alkyl, C 1 -C 4 -alkylsulfinyl and C 1 -C 4 -alkylsulfonyl, in particular chloro, methyl, ethyl, methoxy, methylthio, methylsulfinyl and methylsulfonyl), or Ar 1 is optionally substituted heteroaryldiyl such as an optionally substituted azaheteroaryldiyl group (e.g. an optionally substituted pyridinediyl group, preferably a p-pyridinediyl group) in which the optional substituents include an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 carbon atoms, in particular methyl and a methoxy group, and more preferably a pyridine-2,5-diyl group wherein R ⁵ -L ⁵ - is adjacent to the nitrogen atoms of the pyridyl moiety and is substituted at the 4-position or the 6-position with a methyl group, or a methoxy group,

L ⁵ represents a group -C (= O) -NH-, and

R ⁵ represents a heterocycloalkyl group, in particular a bicyclic amino group having 9 to 10 atoms, preferably an indolinyl group.

O

In particular, R can be a hydrogen atom.

In particular, R ^ may also represent a lower alkyl group (such as a methyl group).

O

In particular, the substituent R may also be a lower alkoxy group (such as a methoxy group).

Substituent A ⁴ may in particular be an alkylene chain having 2 to 3 carbon atoms, such as an ethylene group and a trimethylene group, in particular an ethylene group.

In particular, the substituent Z - * - may be 0.

The substituent Z ⁴ may also particularly represent a group

Ύ Ύ 17

NR in which R represents:

(i) a hydrogen atom, (ii) a -C (= O) -R 9 group in which R 6 has the same meaning as defined above, in particular an optionally substituted aryl group (such as an optionally substituted phenyl group), an alkyl group containing C 1 -C 4 alkyl (such as methyl), C 1 -C 4 alkyl substituted with an acidic group (such as -CH 2 -CH 2 CO 2 H), or C 2 -C 4 alkyl substituted with -NY ⁴ Y ^4; wherein Y ⁴ and Y ^ are as defined above (e.g. -CH2CH2NMe2 group), or (iii) -C (= 0) -0R ¹⁴ in which R ¹⁴ has the same meaning as defined above in particular an alkyl group (such as a tertiary butyl group).

In particular, the substituent li may be an optionally substituted alkylene group, in particular an optionally substituted ethylene or propylene group, preferably an optionally substituted

ethylene. Preferred substituents include lower alkyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -n (r ⁸ ) -so 2 -r ⁹ , -ny ⁴ y ⁵ a - [C (= O) -N (R ⁴⁰ ) -C (r ⁵ ) (R ⁴⁴ )] p C (= O) - ΝΥ ⁴ γ5 or an alkyl group substituted with a carboxy group (or an acidic bioisoster), -ZH, -ZR ⁴⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ . In one preferred embodiment, L ⁴ is a group

R ⁵

-C —CH ₂ R ¹⁵ [in which:

R @ 1 is hydrogen or lower alkyl (such as methyl);

R ⁴ represents a hydrogen atom or a lower alkyl group,

S is or R is hydrogen and R is aryl

OQ, heteroaryl, -N (R 0) -C (= O) -R, -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ or - [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ )] -C (= O) -NY ⁴ Y ⁵ or is an alkyl group substituted with carboxy (or acidic bioisoster), -ZH, -ZR ⁴⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ ], and is preferably a group

Ή — CH ₂ - especially -CH-CH ₂ - | 15 [in which R ⁴ is hydrogen, lower alkyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ⁴ γ ⁵ or an alkyl group substituted with

carboxy, -OH, -OR ¹⁴ or -C = O) -NY ⁴ Y ⁴ ].

In another preferred embodiment, L ¹ is -CH.

R ^15a [in which:

r5 represents a hydrogen atom or a lower alkyl group (such as a methyl group, and

Rl5a _is lower alkyl, or

R is hydrogen, and R A _is a aryl, heteroaryl, -N ^(R8) -C (= 0) -R ^9, -N (R ⁸⁾ -C (= O) -OR ^9, -N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ or

- [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ )] -C (== O) -NY ⁴ Y ⁵ or is

Ir is an alkyl group substituted with a carboxy group (or an acidic bioisoster), -ZH, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁴ or -NY ⁴ Y ⁴ ], and is preferably a group

-CH ₂ —CH— especially a group

R ^15a [where R ^ ³ · ¹ is -N (R ⁸⁾ -C (= 0) -R ⁹ or -N (R ⁸⁾ -SO ₂ -R ^9].

In particular, L ¹ may also be -Z ² -R ¹² -, such as -O-CH ₂ -, -O-CH ₂ -CH ₂ -, -S (O) _n -CH ₂ -, -S ( O) _n -CH ₂ -CH ₂ -, -NH-CH ₂ - or -NH-CH ₂ -CH ₂ -.

In particular, L ¹ may also represent a group

-CH.

-CH—

R ^15a

-iAl ⁶ -L ⁷ , in which:

(i) L ³ and both are a direct bond and L g is an optionally substituted heterocycloalkylene group, such as a pyrrolidinediyl group, in particular

3,4-pyrrolidinediyl, or cycloalkylene, such as cyclopentyl, (ii) L ³ is alkylene, such as methylene, L ³ is cycloalkylene, such as cyclopentyl, and L is a direct bond, or (iii) L 0 represents a direct bond, L 0 represents a cycloalkylene group such as a cyclopentyl group, and L 2 represents a direct bond; means an alkylene group such as a methylene group.

In particular, the substituent Y may be a carboxy group.

It is to be understood that all suitable combinations of the individual and preferred groups mentioned above are within the scope of the present invention.

A particular group of compounds of the present invention are compounds of formula (Ix):

in which:

11 ^ 4

R, R, Ar, L, L, L, and Y have the same meaning as previously defined, and

17 17

Z- ¹ represents a group NR (in which R has the same meaning as defined above), and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of the compounds of formula (Ix) above, and prodrugs thereof.

Another particular group of compounds of the present invention are compounds of formula (Ia):

(la)

Q i 114 1 in which R, R, Ar ^χ, L, L, Y and Z ^x as previously defined, and the corresponding N-oxides and their prodrugs, as well as pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N-oxides and prodrugs.

According to the invention, compounds of formula a (Ia) in which R represents an optionally substituted aryl group, in particular an optionally substituted phenyl group, such as a 2-substituted phenyl group, in particular a 2-methylphenyl group, are preferred.

Also preferred according to the invention are compounds of formula (Ia) in which R represents an optionally substituted heteroaryl group, in particular an optionally substituted pyridyl group, such as an optionally substituted 2-pyridyl group, in particular

2-methyl-2-pyridyl.

Also preferred are compounds of formula (Ia) wherein Ar 1 is an optionally substituted phenylene group, especially an optionally substituted m- or p-phenylene group, especially an optionally substituted p-phenylene group. Particularly preferred are compounds of the above formula (ia) in which Ar 1 is

A 3-substituted p-phenylene group in which said substituent is located in the ortho position to position the R ³ -NH-C (= O) -NH- group. Preferred optional substituents include halogens, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfinyl, and C 1 -C 4 alkylsulfonyl. in particular chlorine, methyl, ethyl, methoxy, methylthio, methylsulfinyl and methylsulfonyl.

Also preferred are compounds of the above formula (Ia) wherein Ar 1 is an optionally substituted heteroaryldiyl group, such as an optionally substituted pyridinediyl group, especially a p-pyridinediyl group, especially pyridine-2,5-diyl, and a group in which R -NH-C (= O) -NH- is adjacent to the nitrogen atom of the pyridyl moiety which is substituted in the 4 or 6 position. Preferred optional substituents include an alkyl group containing 1 to 4 carbon atoms and an alkoxy group containing 1 to 4 carbon atoms,

In particular methyl and methoxy.

Also preferred are compounds of formula (Ia) wherein L ⁴ is a straight or branched chain alkylene group having 1 to 6 carbon atoms, preferably a straight chain branched alkylene group having 1 to 4 carbon atoms, such as a methylene group; an ethylene group, particularly preferably a methylene group.

Preferred are compounds of formula (Ia) wherein A ⁴ is an ethylene group.

Preferred are compounds of formula (Ia) wherein Z ⁴ is O.

Also preferred are compounds of formula (Ia) wherein Z ³ is NH.

Also preferred are compounds of the above formula (Ia) wherein Z ⁴ is NC (= O) -R ⁹ wherein R ⁹ is:

(i) an optionally substituted aryl group, such as an optionally substituted phenyl group, (ii) an alkyl group having 1 to 4 carbon atoms (such as a methyl group), an alkyl group having 1 to 4 carbon atoms substituted with an acidic group (such as -CH 2 -CH 2 CO 2 H) or a (C 2 -C 4) alkyl group substituted with -NY ⁴ Y ⁴ wherein Y ⁴ and Y ⁵ have the same meaning as previously defined (such as -CH ₂ CH ₂ NMe ₂ ).

Also preferred are compounds of the above general

of formula (Ia) in which Z ¹ represents an -NC (= O) -OR ^{14 group} in which R ⁴ represents an alkyl group (such as a tertiary butyl group).

Preference is also given to compounds of the above general formula (Ia) in which R represents a hydrogen atom.

Also preferred are compounds of formula (Ia) in which ΐΛ represents an optionally substituted alkylene group, in particular an optionally substituted ethylene group or an optionally substituted propylene group, in particular an optionally substituted ethylene group substituted by lower alkyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ or

- [C (= O) -N (r 10) -C (r 5) (rH)] -C (= O) -NY ⁴ Y ⁵ or an alkyl Jr substituted by carboxy (or acidic bioisoster), -ZH, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ . In one preferred embodiment, ΐΛ is a group

-C-CH ₉ I

R ¹⁵ [in which:

r5 is a hydrogen atom or a lower alkyl group (such as a methyl group); and r5 is a hydrogen atom or a lower alkyl group; -C (= O) -R, -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ or _ [C (= O) ) -N (R - ^) - C (r5) (rH)] pC (= O) - ΝΥ ⁴ γ5 or

alkyl substituted by carboxy (or an acid bioisostere), -ZH, -zr ^14, -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ^5], and preferably represents a group: H ₉ CH - group, particularly

CH-CH15 [wherein R is hydrogen, lower alkyl, aryl, heteroaryl, -N ^(R8) -C (= O) ^-R9, -N ^(R8) -C (= O -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ^{4 5 5} or an alkyl group substituted with a carboxy group, -OH, -OR ⁴⁴ or -C = O) -NY ⁴ Y ⁴ ].

In another preferred embodiment, L ⁴ is a group

R ~ _O -C- CH

15a [in which:

R 6 represents a hydrogen atom or a lower alkyl group (such as a methyl group), and

⁴ R 5a _represents a lower alkyl group, or represents hydrogen and R ⁴ is aryl ^and $ OQ, heteroaryl, -N (R c) -C (= 0) -R, -N (R ⁸⁾ -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ or - [c (= O) -N (R ⁴⁰ ) -C (R 8) (R ⁴⁴ ) ] -C (= O) -NY ⁴ Y ⁵ or is an alkyl group substituted with carboxy (or an acidic bioisoster), -ZH, -ZR ⁴⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ ], and in a preferred embodiment, the group: h _{2 is} -CH ₂ especially

R ^15a

CH _{O -} CH - i

R ^45a [in which R ^13a means R ^13a means R 45a] -N (R ⁸ ) -C (= O) -R ⁹ or -N (R ⁸ ) -SO ₂ -R ⁹ ].

Also preferred are compounds of the above formula (Ia) wherein Y is carboxy.

Preference is also given to compounds of the general formula (Ia) in which:

means a hydrogen atom,

R ^j represents a 2-substituted phenyl [especially

2-methylphenyl or 2-methoxyphenyl],

A ¹ represents an ethylene group,

Ar ¹ represents an optionally substituted m-phenylene or p-phenylene group (especially

3-chloro-p-phenylene, 3-methyl-p-phenylene, 3-ethyl-p-phenylene,

3-methoxy-p-phenylene, 3-methylthio-p-phenylene, 3-methylsulfinyl-p-phenylene and 3-methylsulfonyl-p-phenylene) or optionally substituted p-pyridinediyl group [especially 4 (or 6)] -methyl (or methoxy) -p-pyridine-2,5-diyl group],

L ¹ represents a group

especially the group

-CH15 CH ₂ - in which R ¹³ is hydrogen, lower alkyl, aryl, heteroaryl, -N ^(R8) -C (= O) ^-R9, -N ^(R8) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -NY ⁴ Y ³ or an alkyl group substituted with a carboxy group (or an acidic bioisoster), -OH, -OR ¹⁴ , -C = O) -NY ⁴ Y ⁵ ,

L ⁴ represents a straight-chain or branched alkylene group having 1 to 6 carbon atoms, in particular a methylene group,

Y is carboxy, and

Ά means 0, NH, NC (= O) R ^ [especially NC (= O) -Ph, NC (= O) -CH ₃ , NC (= O) -CH ₂ CH ₂ CO ₂ H and NC (= O) ) -CH ₂ CH ₂ NMe ₂ ] or NC (= O) -OR ⁴ [particularly NC (= O) -OCMe ₃ ], and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as are, for example, hydrates) of these compounds and their N-oxides and prodrugs.

Another preferred group of compounds of the present invention are those compounds of formula (Ia), wherein:

R 6 represents a hydrogen atom,

R ³ represents a 2-substituted phenyl group [in particular a 2-methylphenyl group or a 2-methoxyphenyl group], means an ethylene group,

Ar 1 represents an optionally substituted m-phenylene or p-phenylene group (especially 3-chloro-p-phenylene, 3-methyl-p-phenylene, 3-methoxy-p-phenylene,

3-methylthio-p-phenylene,

3-methylsulfinyl-p-phenylene and 3-methylsulfonyl-p-phenylene) or optionally substituted p-pyridinediyl group [in particular 4 (or 6) -methyl (or methoxy) -p-pyridine-2,5-diyl] , ΐΛ stands for a group

_O -CH -CH -CH especially ₇ -CH

I l jjl5a r15u [wherein R ^3a represents a radical -N (R ^) - C (= 0) -R, or • »9 and 9 ·» ·.

··· · ·. ··· · · «J ·· ♦ ··! I9 ·· ·

9 9 99 9 9 9 9 ··· 99 9 9 999 99 99

-N (R ⁸ ) -SO ₂ -R ⁹ ],

L ⁴ represents a straight-chain or branched alkylene group having 1 to 6 carbon atoms, in particular a methylene group,

Y is carboxy, and

Z ^ means 0, NH, NC (= O) R ⁹ [especially NC (= O) -Ph, NC (= O) -CH 3, NC (= O) -CH 2 CH 2 CO 2 H and NC (= O) -CH 2 CH 2 NH 2) or NC (= O) -Or ¹⁴ (especially NC (= O) -OCMe 3), and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds, and N-oxides and prodrugs thereof pharmaceuticals.

Another preferred group of compounds of the present invention are compounds of formula (Ib):

(Ib) in which:

R ² , R ³ , A ⁴ , L ² , Y and Z ¹ have the same meaning as previously defined,

X is NR ³ or O,

Z ⁴ is a direct bond, NR ³ , O or S (O) _n (wherein R ³ and N have the same meaning as previously defined), and

R represents a hydrogen atom or a substituent of an aryl group, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and N-oxides and prodrugs thereof.

According to the invention, compounds of the general formula (Ib) are preferred in which they represent an optionally substituted aryl group, in particular a 2-substituted phenyl group. Preferred optional substituents are lower alkyl groups (such as a methyl group), lower alkoxy groups (such as a methoxy group), halogens (such as a fluorine or chlorine) and a Y Y Na group (for example a dimethylamino group). In particular, R represents an ortho-tolyl group.

Also preferred are compounds of formula (Ib) wherein Z ⁴ is NH.

Also preferred are compounds of formula (Ib) wherein R is hydrogen, halogen (such as chlorine), lower alkyl (such as methyl or ethyl), or lower alkoxy (such as methoxy) ).

Also preferred according to the present invention are compounds of formula (Ib) wherein L ⁴ is a straight or branched chain alkylene group having 1 to 6 carbon atoms, in particular a straight or branched chain alkylene group having 1 to 4 carbon atoms, yet more preferably a methylene group.

They are also preferred according to the present invention

• 9 9 • · · • β · (· · · 9 · ·· • · · j: • · • · · · • 9 99 • ·

a compound of formula (Ib) in which it is an ethylene group.

Also preferred are compounds of formula (Ib) wherein O is O.

Also preferred are compounds of formula (Ib) wherein Z 1 is NH.

Also preferred are compounds of formula (Ib) wherein Z 1 is N-C (= O) -R 9 wherein R 1 is:

(i) an optionally substituted aryl group, such as an optionally substituted phenyl group, (ii) an alkyl group having 1 to 4 carbon atoms (such as a methyl group), an alkyl group having 1 to 4 carbon atoms substituted with an acidic group (such as -CT (CT (CC (H)) or a (C 4-C alky) alkyl group substituted with -NY ^ Y ^ in which Y ⁴ and Y ^ have the same meaning as previously defined (such as -CH ² CH ² NMe ² ).

Also preferred are compounds of formula (Ib) wherein Z 1 is NC (= O) -OR ⁴ *, in which R ⁴ * ⁴ is an alkyl group (such as a tertiary butyl group) .

Also preferred are compounds of formula (Ib) wherein R is hydrogen.

• · · • · · • ·· • · ·· · • * • »· • f · t • 9 9 • · « • · • * 9 • · · 9 • 9 9 · 9 9

Also preferred are compounds of formula (1b), wherein L ¹ represents an optionally substituted alkylene group, especially an optionally substituted ethylene group or an optionally substituted propylene group, especially an optionally substituted ethylene group substituted with a lower alkyl group, aryl group, heteroaryl group, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ or

- [C (= O) -N (R 10) -C (R ⁵ ) (R ¹¹ )] _D -C (= O) -NY ⁴ Y ⁵ or an alkyl group substituted with a carboxy group (or an acidic bioisoster), -ZH , -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ . In one preferred embodiment, L ¹ is a group

-C-CH ₉ I

R ¹⁵ [in which:

R @ ⁵ is hydrogen or lower alkyl (such as methyl);

R ¹⁵ is hydrogen or lower alkyl, or R ⁵ is hydrogen and R ¹⁵ is aryl, heteroaryl, -N (R °) -C (= O) -R, -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ or - [C (= O) -N (R ⁴ O) -C (R ⁵ ) (R ¹¹⁾ )] -C (= O) -NY ⁴ Y ⁵ or is an alkyl group substituted with carboxy (or an acidic bioisoster), -ZH, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ ] , and is preferably a group

H-CH 15 especially a group

-CH15 ch ₂ - • φ φ φ φ φ φ φ φ φ φ

[in which R ¹ is hydrogen, lower alkyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) - OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ^{4 5} or an alkyl group substituted with a carboxy group, -OH, -OR ¹⁴ or -C = O) -NY ⁴ Y ⁴ ].

In another preferred embodiment, L ¹ is -CH

15a [in which:

R1 is hydrogen or lower alkyl (such as methyl, and

R ¹ ^ ³ · is lower alkyl, or R5 is hydrogen and ^R1 ^ ³ · _Zn on AMEN aryl, heteroaryl, -N (R c) -C (= 0) -R, -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO 2 -R ⁹ , -NY ⁴ Y ⁵ or - [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) ( R ¹¹ )] n C (= O) -NY ⁴ Y ⁵ or is an alkyl group substituted with a carboxy group (or an acidic bioisoster), -ZH, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ ], and is preferably a group

-CH ₂ —CH— especially -CH ₂ -CH-

Řl5a-15a [wherein R ¹ · ^ ³ represents -N (R ⁸⁾ -C (= 0) -R ⁹ or -N (R ⁸⁾ -SO ₂ -R ^9].

Also preferred are compounds of formula (1b) above wherein Y is carboxy.

Group of formula • «·

• <

A * * •....

may preferably be attached to the ring at the 6-position or at the 5 or 6 position when X is NR 6 and R 8 is lower alkyl.

A preferred group of compounds of the present invention are those compounds of formula (Ib) wherein:

-R represents a hydrogen atom, a chlorine atom, a methyl group, an ethyl group or a methoxy group,

R is hydrogen,

R 6 represents an optionally substituted aryl group (especially an ortho-tolyl group),

A ⁴ represents an ethylene group,

L ⁴ represents a group

_-CH-CH2 - especially -CH-CH ₂ -

R 15 - R 15 wherein R ⁴ is hydrogen, lower alkyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) ) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -NY ⁴ Y 8 or an alkyl group substituted with a carboxy group (or an acidic bioisoster), -OH, -ZR ⁴⁴ , -C = O) -NY ⁴ Y ^ or -NY ⁴ Y ⁵ ,

L ⁴ represents a straight-chain or branched alkylene group having 1 to 4 carbon atoms, in particular a methylene group,

X is 0,

Y is carboxy, and

Z ¹ is 0, NH, NC (= O) R ^ [especially NC (= O) -Ph, NC (= O) -CH 3, NC (= O) -CH 2 CH 2 CO 2 H and NC (= 0) -CH 2 CH 2 NH 2) or NC (= 0) -0R ¹⁴ [especially NC (= O) -0CMe3],

Z ⁴ is NH, and a group of formula

is attached to the ring at the 6-position, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N-oxides and prodrugs.

Another preferred group of compounds of the present invention are those compounds of formula (Ib) above wherein:

-R represents a hydrogen atom, a chlorine atom, a methyl group, an ethyl group or a methoxy group,

R is hydrogen, and

R is an optionally substituted aryl group (especially an ortho-tolyl group),

A 1 represents an ethylene group, represents a group

especially the group

-CH.

-CH 15a [wherein R _6a is -N (R ⁸ ) -C (= O) -R ⁹ or

-N (R ⁸ ) -SO ₂ -R ⁹ ],

L ⁴ represents a straight or branched chain alkylene group having 1 to 4 carbon atoms, in particular a methylene group,

X is 0,

Y is carboxy, and

Z ¹ is O, NH, NC (= O) R ⁹ [especially NC (= O) -Ph, NC (= O) -CH ₃ , NC (= 0) -CH ₂ CH ₂ CO ₂ H and NC (= O) -CH ₂ CH ₂ NMe ₂ ] or NC (= O) -OR ¹⁴ [especially NC (= O) -OCMe ^],

Z ⁴ is NH, and a group of formula

is attached to the ring at the 6-position, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N-oxides and prodrugs.

Another preferred group of compounds of the present invention are those compounds of formula (1b) above wherein:

O

R is hydrogen,

R 6 represents an optionally substituted aryl group (especially an ortho-tolyl group),

A ⁴ is an ethylene group, L ⁴ is a group

H — CH2 — especially group 15

-CH-CH 15 in which R ⁴ represents hydrogen, lower alkyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -NY ⁴ Y ⁸ or a carboxy-substituted alkyl group (or an acidic bioisoster), -OH, -OR ⁴⁴ , -C = O) -NY ⁴ Y ^ or -y ⁴ y ⁵ ,

L ⁴ represents a straight-chain or branched (C 1 -C 4) alkylene group (in particular a methylene group),

X is NR (especially NH),

Y is carboxy, and

Z ⁴ denotes 0, NH, NC (= O) R ⁹ [in particular NC (= O) -Ph, NC (= O) -CH ₃ , NC (= O) -CH ₂ CH ₂ CO ₂ H and NC (= O) -CH ₂ CH ₂ NMe ₂ ] or NC (= O) -OR ⁴⁴ [especially NC (= O) -OCMe 2],

Z ⁴ is NH, and a group of formula

is attached to the ring at the 5 or 6 position, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as

hydrates) of these compounds and their N-oxides and prodrugs.

Another preferred group of compounds of the present invention are those compounds of formula (Ib) above wherein:

o _z represents a hydrogen atom,

R ³ represents an optionally substituted aryl group (especially an ortho-tolyl group),

A “* · represents an ethylene group, ΐΛ represents a group

CH _O —CH—

In particular, _R 15a is a group

CH-CH-i

> 15a [wherein R ^3a represents a group -N (R ⁸⁾ -C (= 0) -R ⁹ or -N (R ⁸⁾ -SO 2 -R ^9],

L ⁴ represents a straight or branched chain alkylene group having 1 to 4 carbon atoms, in particular a methylene group,

X is NR ³ (especially NH),

Y is carboxy, and

Z ¹ denotes 0, NH, NC (= O) R ⁹ [especially NC (= O) -Ph, NC (= O) -CH 3, NC (= O) -CH 2 CH 2 CO 2 H and NC (= O) -CH 2 CH 2 NMe 2] or NC (= 0) -0R ^ ⁴ [especially NC (= 0) -0CMe3],

Z ⁴ is NH, and a group of formula

it is attached to the ring in position 5 or 6, • * • 9 4

9 9 9

and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and N-oxides and prodrugs thereof.

Another preferred group of compounds of the present invention are compounds of formula (Ic):

(Ic) wherein: Ar ¹ , L ⁴ , A ¹ ,, L ¹ , Y and Z ¹ have the same meaning as defined above, and the corresponding N-oxides and prodrugs thereof, as well as pharmaceutically acceptable salts and solvates ( such as hydrates) of these compounds and their N-oxides and prodrugs.

Preferred are compounds of formula (Ic) wherein Ar ¹ is an optionally substituted phenylene group, especially an optionally substituted m-phenylene or p-phenylene group, particularly preferably an optionally substituted p-phenylene group. Particularly preferred are compounds of formula (Ic) in which Ar ¹ represents a 3-substituted p-phenylene group in which the substituent is located ortho to position the group

.NS

Preferred optional substituents include halogens, (C 1 -C 4) alkyl, (C 1 -C 4) alkoxy, (C 1 -C 4) alkylthio, (C 1 -C 4) alkylsulfinyl, (C 1 -C 4) alkylsulfonyl group especially substituents include chloro, methyl, ethyl, methoxy, methylthio, methylsulfinyl and methylsulfonyl.

Also preferred are compounds of formula (Ic) wherein Ar ¹ is an optionally substituted heteroaryldiyl group, such as an optionally substituted pyridinediyl group, especially a p-pyridinediyl group, especially pyridine-2,5- a diyl group in which the group is located adjacent to the pyridyl nitrogen atom, which group is optionally substituted in the 4 or 6 position. The substituents present may include an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 groups. carbon atoms, in particular methyl and methoxy.

Also preferred are compounds of the above formula (1c) wherein L ⁴ is a straight or branched chain alkylene group having 1 to 6 carbon atoms, in particular a straight chain alkylene group having 1 to 4 carbon atoms, in particular a straight chained or branched alkylene group. methylene.

Also preferred according to the invention are compounds of the above formula (1c), wherein A ⁴ represents an ethylene group.

Also preferred according to the invention are compounds of the above formula (1c) wherein Z ⁴ is O.

Also preferred according to the invention are compounds of the above formula (1c) wherein Z ⁴ is NH.

Also preferred according to the present invention are compounds of the above formula (1c), wherein Z ⁴ is NC (= O) -R ⁹ , wherein R ⁹ is:

(i) an optionally substituted aryl group such as an optionally substituted phenyl group; (ii) an alkyl group having 1 to 4 carbon atoms (such as a methyl group), an alkyl group having 1 to 4 carbon atoms substituted with an acidic group (such as for example -CH 2 -CH 2 CO 2 H) or a (C 2 -C 4) alkyl group substituted with -NY ⁴ Y ⁴ in which Y ⁴ and Y ⁵ have the same meaning as previously defined (such as ···

-CH ₂ CH ₂ NMe ₂ ).

Also preferred are compounds of formula (1c) above wherein τλ is -NC (= O) -OR ⁴ where R ⁴ is an alkyl group (such as a tertiary butyl group).

Also preferred are compounds of the above formula (1c) wherein o

R is hydrogen.

Also preferred are compounds of formula (1c) wherein ΐΛ represents an optionally substituted alkylene group, especially an optionally substituted ethylene group or an optionally substituted propylene group, especially an optionally substituted ethylene group substituted with a lower alkyl group, an aryl group, a heteroaryl group , -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ or

- [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ )] _p -C (= O) - NY ⁴ Y ⁵ or an alkyl group substituted with a carboxy group (or an acidic bioisoster), -ZH, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ . In one preferred embodiment, ΐΛ is a group

-C-CH ₉ I

R ¹³ [in which:

R is a hydrogen atom or a lower alkyl group (such as a methyl group);

R ³ is hydrogen or lower alkyl, or R is hydrogen and R ¹ is aryl of Q, heteroaryl, -N (R 0) -C (= O) -R, -N (R 3) ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO 2 -R ⁹ , -NY ⁴ Y ⁵ or - [C (= O) -NR ¹ R ³ ) -C (R ³ ) (R ³ ) ¹¹ )] n C (= O) -NY ⁴ Y ⁵ or is an alkyl group substituted with a carboxy group (or an acidic bioisoster), -ZH, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ ] , and in a preferred embodiment, is h-ch ₂ - especially a group

-CH-CH.

[wherein R ¹³ represents hydrogen, lower alkyl, aryl, heteroaryl, -N ^(R8) -C (= O) ^-R9, -N ^(R8) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ^{4 5 5} or an alkyl group substituted with a carboxy group, -OH, -OR ¹⁴ or -C = O) -NY ⁴ Y ³ ].

In another preferred embodiment, L ¹ is a group

R '; Ho — C—

15a [in which:

R ³ represents a hydrogen atom or a lower alkyl group (such as a methyl group), and

RÍ5a _represents a lower alkyl group (e.g. methyl), or

R ³ is hydrogen and R ^13a is aryl of Q, heteroaryl, -N (R °) -C (= O) -R, -N (R ⁸ ) -C (= O) -OR ⁹ , - N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ or - [C (= O) -N (R ⁶ ) - (R ³ ) (R ¹¹ )] -C (= O -NY ⁴ Y ⁵ or is an alkyl group substituted with carboxy (or an acidic bioisoster), -ZH, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ ], and is preferably a group

-CH ₂ —CH— especially -CH ₂ -CH-

Řl5a R - * - 5 [wherein R ^^ ^and represents -N (R ⁸⁾ -C (= 0) -R ⁹ or -N (R ⁸⁾ -SO ₂ -R ^9].

Also preferred are compounds of the above formula (Ic) wherein Y is carboxy.

Preferred are also compounds of the above formula (Ic) wherein: o

R is hydrogen,

Ϊ

A represents an ethylene group,

-and

Ar is optionally substituted m-phenylene or p-phenylene (especially 3-chloro-p-phenylene, 3-methyl-p-phenylene, 3-methoxy-p-phenylene,

3-methylthio-p-phenylene,

3-methylsulfinyl-p-phenylene and 3-methylsulfonyl-p-phenylene) or optionally substituted p-pyridinediyl group [in particular 4 (or 6) -methyl (or methoxy) -p-pyridine-2,5-diyl] ,

L ¹ represents a group

-CH-CH ₂ - especially -CH-CH ₂ - R 15 R 15 wherein R 14 represents hydrogen, methyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) ) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ⁴ γ ⁵ or alkyl substituted with

carboxy, -OH, -OR ⁴ or -C = O) -NY ⁴ Y ⁴ ,

L ⁴ represents a straight-chain or branched (C 1 -C 4) alkylene group (in particular a methylene group),

Y represents a carboxy group, and represents 0, NH, NC (= O) R ^ [especially NC (= O) -Ph, NC (= O) -CH ₃ , NC (= O) -CH ₂ CH ₂ CO ₂ H, and NC (= O) -CH ₂ CH ₂ NMe ₂ ] or NC (= O) -OR ¹⁴ [in particular NC (= O) -OCMe ₃ ], and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N-oxides and prodrugs.

Another preferred group of compounds of the present invention are those compounds of formula (Ic) above wherein:

O

R is hydrogen,

A ¹ represents an ethylene group,

Ar 1 represents optionally substituted m-phenylene or p-phenylene (especially 3-chloro-p-phenylene, 3-methyl-p-phenylene, 3-methoxy-p-phenylene, 3-methylthio-p-phenylene group

3-methylsulfinyl-p-phenylene and 3-methylsulfonyl-p-phenylene) or optionally substituted p-pyridinediyl group [in particular 4 (or 6) -methyl (or methoxy) -p-pyridine-2,5-diyl] , ΐΛ stands for a group

-CH ₂ —CH— especially a group

-CHh

15a

-CH l

15a [in which R ^ ^ ^a represents the group -N (R ^) - C (= O) -R ^ or

-N (R ⁸ ) -SO ₂ -R ⁹ ],

L ⁴ represents a straight-chain or branched (C 1 -C 4) alkylene group (in particular a methylene group),

Y is carboxy, and

Z ¹ is 0, NH, NC (= O) R ⁹ [especially NC (= O) -Ph, NC (= O) -CH 3, NC (= O) -CH 2 CH 2 CO 2 H and NC (= 0) -CH 2 CH 2 NH 2) or NC (= O) -OR ¹⁴ [especially NC (= O) -OCMe 3], and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds, and N-oxides and prodrugs thereof pharmaceuticals.

Another particular group of compounds of the present invention are compounds of formula (Id):

(Id) wherein R, A, R, LY and Z have the same meaning as previously defined and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N -oxides and prodrugs.

According to the invention, the compounds of the above-mentioned general formula (Id) are preferred, in which R represents an optionally substituted aryl group, in particular an optionally substituted aryl group, in particular an optionally substituted aryl group.

999

9 9

9

9 9

9

A substituted phenyl group. Preferred optionally present substituents include aryloxy, cyano, halogens (such as chloro or fluoro), lower alkoxy (such as methoxy), lower alkyl (such as methyl), nitro and perfluoro-lower-alkyl (such as trifluoromethyl. Particularly preferably, R ³ is 2-chlorophenyl, 5-chloro-2-cyanophenyl, 2-chloro-6-methylphenyl, 2,6-dichlorophenyl, 2,6-difluorophenyl, -fluoro-2-trifluoromethyl, 2-methyl-4-nitrophenyl,

2-methyl-5-nitrophenyl, 2-nitrophenyl,

3-nitrophenyl and 2-phenoxyphenyl.

Also preferred are o

compounds of the above formula (Id) in which R represents an optionally substituted heteroaryl group, in particular an isoquinolinyl group, an isoxazolyl group, a pyrazolopyrimidinyl group, a pyridyl group, a pyrimidinyl group, a quinolinyl group, a thiazolyl group and a triazolyl group, each of which may be optionally substituted with one or more aryl group substituents. Preferred optional substituents include alkyl-C (= O) -, aryl, cyano, halogens (such as chlorine or fluorine), lower alkoxy (such as methoxy), lower alkyl (such as methyl) ), lower alkylsulfonyl, lower alkylthio, nitro and perfluoro-lower-alkyl (such as trifluoromethyl).

Particularly preferably, R ³ represents quinolin-4-yl, isoquinolin-2-yl, 2,4-pyridin-3-yl,

• tftf • · • • « • · · • · • · • · tf tf · • · • •> • · · · • · • tftf < Tf · · tf e • · · • ·

tf i

tftf

2,6-dimethyl-4-trifluoromethylpyridin-3-yl,

4-trifluoromethylpyridin-3-yl,

2-phenyl-4-methyl-1,2,3-triazol-5-yl,

3,5-dimethylisoxazol-4-yl,

2,7-dimethylpyrazolo [1,5-a] pyrimidin-6-yl;

2-isopropyl-4-methylthiazol-5-yl; and 4-trifluoromethylpyrimidin-5-yl.

Also preferred are compounds of the above formula (Id) wherein q

R is an arylalkyl group in which the aryl group is optionally substituted with one or more aryl group substituents (in particular, halogen, hydroxy and methoxy are among those optional substituents). More preferably, R ⁸ is an arylalkyl group in which the aryl group is optionally substituted with one or more aryl group substituents (particularly preferred optionally present substituents include halo, hydroxy and methoxy). In particularly preferred embodiments, R ^J is an optionally substituted benzyl group, it is particularly

4-hydroxybenzyl, 3-chloro-4-hydroxybenzyl, 3-fluoro-4-hydroxybenzyl and 4-hydroxy-3-methoxybenzyl.

Also preferred are compounds of the above formula (Id) wherein A ⁴ is an ethylene group.

Also preferred are compounds of the above formula (Id) wherein Z ⁴ is O.

68 - • * 1 • · · · ·· · {: ·: • ·· • ♦ · ·· · «· • · e · · ·· 4 »

Also preferred are compounds of the above formula (Id) in which NH is.

Also preferred are compounds of the above formula (Id) wherein A is NC (= O) -R ⁹ wherein R ⁹ is:

(i) an optionally substituted aryl group, such as an optionally substituted phenyl group, (ii) an alkyl group having 1 to 4 carbon atoms (such as a methyl group), an alkyl group having 1 to 4 carbon atoms substituted with an acidic group (such as -CH ₂ CH ₂ CO ₂ H) or a (C 2 -C 4) alkyl group substituted with -NY ⁴ Y ³ in which Y ⁴ and Y ³ have the same meaning as previously defined (such as -CH ₂ CH ₂ NMe ₂ ) ·

Also preferred are compounds of the above formula (Id) wherein Z ¹ is -NC (= O) -OR ⁴ where R ⁴ is an alkyl group (such as a tertiary butyl group).

Also preferred are compounds of the above formula (Id) wherein R is hydrogen.

Also preferred are compounds of the above formula (Id) in which iA represents an optionally substituted alkylene group, in particular an optionally substituted ethylene group or an optionally substituted propylene group, in particular.

9 9 9

9 9

9 9

9 9 9

An ethylene group optionally substituted by a lower alkyl group (such as a methyl group), an aryl group, a heteroaryl group, a

-N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO 2 -R ⁹ , -NY ⁴ Y ⁵ or - [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ )] p C (= O) -NY ⁴ Y ⁵ or a carboxy-substituted alkyl group (or an acidic bioisoster), -ZH, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ . In one preferred embodiment, L ¹ is a group

R ⁵

AND

-C-CHoI

R ¹⁵ [in which:

R @ ⁵ is hydrogen or lower alkyl (such as methyl);

R ¹⁸ represents a hydrogen atom or a lower alkyl group,

S ts or R is hydrogen and R is aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , - N (R ⁸ ) -SO 2 -R ⁹ , -NY ⁴ Y ⁵ or - [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ )] p C (= O) -NY ⁴ Y ⁵ or an alkyl group substituted by carboxy (or an acid bioisostere), -ZH, -zr ^14, -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ^5], and more preferably represents a group

_-CH-CH2 - especially -CH-CH ₂ -

R ¹⁵ R ¹⁵ [wherein R ¹³ is hydrogen, lower alkyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -NY ⁴ Y ⁵ or a carboxy-substituted alkyl group, -OH, -OR ¹⁴ or -C = O) -NY ⁴ Y ⁵ ].

* »* Φ φ tt

In another preferred embodiment, L ⁴ is a group

R ~ CH.

15a [in which:

r 5 represents a hydrogen atom or a lower alkyl group (such as a methyl group), and

^And R @ ⁴ is lower alkyl, or R5 is hydrogen and R @ ^{4 a} represents aryl, heteroaryl, -N ^(R8) -C (= 0) -R ^9, -N (R ⁸⁾ - C (= O) -OR ⁹ , -N (R ⁸ ) -SO 2 -R ⁹ , -NY ⁴ Y ⁵ or - [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ ) ] pC (= O) -NY ⁴ Y ⁵ or is an alkyl group substituted with carboxy (or an acidic bioisoster), -ZH, -ZR ⁴⁴ , -C (= O) -NY ⁴ Y ⁴ or -NY ⁴ Y ⁴ ], and even more preferably, is a group

-CH ₂ —CH— especially -CH ₂ -CH-

RÍ5a j ^ LSA [in which R @ ⁴ represents ^a group -N ^(R8) -C (= 0) -R ⁹ or -N (R ⁸⁾ -SO ₂ -R ^9].

Also preferred are compounds of formula (Id) wherein Y is carboxy.

Preference is also given to compounds of the above general formula (Id) in which:

R represents a hydrogen atom, α

R represents an optionally substituted phenyl group (especially 2-chlorophenyl, 5-chloro-2-cyanophenyl) 9

9 9

A 9 * 9 group, a 2-chloro-6-methylphenyl group,

2,6-dichlorophenyl, 2,6-difluorophenyl, 4-fluoro-2-trifluoromethyl,

2-methyl-4-nitrophenyl, 2-methyl-5-nitrophenyl, 2-nitrophenyl, 3-nitrophenyl and 2-phenoxyphenyl), optionally substituted heteroaryl (especially quinolin-4-yl, isoquinolin-2) -yl, 2,4-pyridin-3-yl,

2,6-dimethyl-4-trifluoromethylpyridin-3-yl,

4-trifluoromethylpyridin-3-yl,

2-phenyl-4-methyl-1,2,3-triazol-5-yl,

3,5-dimethoxyisoxazol-4-yl,

2,7-dimethylpyrazolo [1,5-a] pyrimidin-6-yl;

2-isopropyl-4-methylthiazol-5-yl and 4-trifluoromethylpyrimidin-5-yl) or optionally substituted benzyl (especially 4-hydroxybenzyl, 3-chloro-4-hydroxybenzyl, 3-fluoro-4-hydroxybenzyl) and 4-hydroxy-3-methoxybenzyl),

A ⁴ represents an ethylene group,

L ⁴ represents a group

-CH-CH 2 - especially -CH-CH 2 -

Ø ⁴⁵ R ⁴⁵ in which R ⁴ represents hydrogen, methyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O ) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ^{4 5 5} or an alkyl group substituted with a carboxy group, -OH, -OR ⁴⁴ or -C = O) -NY ⁴ Y $,

Y is carboxy, and

Z ⁴ denotes 0, NH, NC (= O) R ⁹ [in particular NC (= O) -Ph, NC (= O) -CH ₃ , NC (= O) -CH ₂ CH ₂ CO ₂ H and NC (= O) -CH ₂ CH ₂ NMe ₂ ] or · · * * · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

NC (= O) -OR ¹⁴ [especially NC (= O) -OCMe ₃ ], and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N-oxides and prodrugs.

Another preferred class of compounds of the present invention are those compounds of formula (Id) above wherein:

R is hydrogen, and

R represents an optionally substituted phenyl group (especially a 2-chlorophenyl group,

5-chloro-2-cyanophenyl, 2-chloro-6-methylphenyl, 2,6-dichlorophenyl, 2,6-difluorophenyl, 4-fluoro-2-trifluoromethyl,

2-methyl-4-nitrophenyl,

2-methyl-5-nitrophenyl, 2-nitrophenyl,

3-nitrophenyl and 2-phenoxyphenyl), optionally substituted heteroaryl (especially quinolin-4-yl, isoquinolin-2-yl,

2,4-pyridin-3-yl,

2,6-dimethyl-4-trifluoromethylpyridin-3-yl,

4-trifluoromethylpyridin-3-yl,

2-phenyl-4-methyl-1,2,3-triazol-5-yl,

3,5-dimethoxyisoxazol-4-yl;

2,7-dimethylpyrazolo [1,5-a] pyrimidin-6-yl;

2-isopropyl-4-methylthiazol-5-yl and 4-trifluoromethylpyrimidin-5-yl) or optionally substituted benzyl (especially

4-hydroxybenzyl, 3-chloro-4-hydroxybenzyl, 3-fluoro-4-hydroxybenzyl and 4-hydroxy-3-methoxybenzyl),

A · * represents an ethylene group,

* * · • · · • Φ · > · • · 9 9 · • • · • ·· · ♦ ♦ 9 9 9 • · • « * ·· 99 · »

L ¹ represents a group

-CH _? —CH— especially the group -CH _O -CH—

I i

£ 15a R 15a [where R and _known Measured -N (R ⁸⁾ -C (= 0) -R ⁹ or -N (R ⁸⁾ -SO ₂ -R ^9],

Y is carboxy, and

Z ¹ is 0, NH, NC (= O) R ⁹ [especially NC (= O) -Ph, NC (= O) -CH ₃ , NC (= O) -CH ₂ CH ₂ CO ₂ H and NC (= O) -CH ₂ CH ₂ NMe ₂ ] or NC (= O) -OR ¹⁴ [especially NC (= O) -OCMe 2], and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as are, for example, hydrates) of these compounds and their N-oxides and prodrugs.

Preferred compounds of the present invention are those compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R ¹ is hydrogen.

Preferred compounds of the present invention are also compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R ¹ is lower alkyl (such as methyl, ethyl, propyl) , butyl group).

Preferred compounds of the present invention are also compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R- ^L 'is an aryl group (such as an optionally substituted phenyl group).

Preferred compounds of the present invention are also compounds of formula (Ia) as defined above,

·· "·· ··· ··· ** (Ib), (Ic) and (Id) in which R ¹ · ³ represents -N (R ⁸⁾ -C (= 0) -R ^9, especially said group in which R ⁸ represents a hydrogen atom or a lower alkyl group (such as a methyl group) and R ⁹ represents a lower alkyl group (such as a methyl group), an aryl group (such as an optionally substituted phenyl group), a heteroaryl group (such as pyridyl, isoxazolyl, triazolyl, pyrimidinyl, thiazolyl or pyrazolopyrimidinyl, each optionally substituted with one or more aryl substituents), alkyl substituted with alkoxy (such as -C -C-O-Cl 2) -CH? -O CH₃), alkyl substituted by carboxy (e.g. -CH ₂ -CH ₂ -CO ₂ H and -CH ₂ -CH 2 -CH ₂ -CO ₂ H) or alkyl substituted by -NY ⁴ Y group ³ (e.g. Example aminomethyl and morpholin-l-ylmethyl).

Preferred compounds of the present invention are also compounds of formulas (Ia), (Ib), (1c) and (Id) as defined above, wherein R ¹³ is -N (R ⁸ ) -C (= O) -OR ⁹ in particular said group in which R ⁸ represents a hydrogen atom or a lower alkyl group (such as a methyl group) and R ⁹ represents a lower alkyl group (such as a methyl group) or an alkyl group substituted by a aryl group (such as a benzyl group) .

Preferred compounds of the present invention are also compounds of formulas (Ia), (Ib), (1c), and (Id) as defined above, wherein R 4 = ³ is -N (R ⁸ ) -C (= O) -SO ₂ R ⁹ , in particular said group in which R ⁸ represents a hydrogen atom or a lower alkyl group (such as

t ♦ · • 4 4 4 4 4 4 4 4 4 4 « 4 4 4 4 4 4 4 4 44 444 4 4 44

R ⁹ is lower alkyl (such as methyl), aryl [such as optionally substituted phenyl or optionally substituted naphthyl (especially dimethylaminonaphth-1-yl)], heteroaryl (such as for example substituted pyridyl or optionally substituted imidazolyl.

Preferred compounds of the present invention are also compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R ¹ is -NY ⁴ Y ⁴ , especially said group in which Y ⁴ and represents a hydrogen atom.

Preferred compounds of the present invention are also compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R ¹ is -NY ⁴ Y ⁴ , especially said group in which Y ⁴ and Y 1 represents a lower alkyl group (such as a propyl group) or an alkyl group substituted with an aryl group (such as a -CH ₂ -Ph or -CH ₂ -CH ₂ -Ph) group.

Preferred compounds of the present invention are also compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R ¹ is -NY ⁴ Y ⁴ , especially said group wherein Y ⁴ and represent an alkyl group substituted with an aryl group (such as -CH ₂ -Ph or -CH (CH ₃ ) -Ph).

Preferred compounds of the present invention are also compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R ¹ is an alkyl group substituted with a carboxy group (or an acidic bioisoster),

in particular a lower alkyl group substituted by a carboxy group (such as a carboxymethyl group).

Preferred compounds of the present invention are also compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R 6 is an -OH-substituted alkyl group, especially a -OH-substituted lower alkyl group (such as such as hydroxymethyl).

Preferred compounds of the present invention are also compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R 1 is an alkyl group

Q is substituted with -OR, especially lower alkyl, and

-0R ^J substituted (such as a methoxymethyl group).

Preferred compounds of the present invention are also compounds of formulas (Ia), (1b), (Ic) and (Id) as defined above, wherein R 1 is an alkyl group substituted with -C (= O) -NY ⁴ Y ⁴ , especially a lower alkyl group substituted with -C (= O) -NY4 Y4 (such as, for example, R @ 1 R @ 1 R @ 2 R @ 3 R @ ³ );

o N — C CH— Me — N N ~ C CH—),

W ² or group • 9 ► «··

Particularly preferred compounds of the present invention are also compounds of formulas (Ia), (Ib), (Ic) and (Id) as defined above, wherein R ³ is:

-NH-C-CH-CH-CO ₂ H, NH-C-CH-CH-CH-CO ₂ H, NH-C-NH-CH.,,

-NH0

II

-c-CH-O-CH ₃ CH ₂ OCH ₃ , o

—NH — C '

·· ♦♦ φ *

ΦΦΦ Φ Φ ΦΦΦ * ΦΦ

ΦΦΦ ΦΦ ΦΦ ΦΦΦ ΦΦ ΦΦΦ

Ν = Ν

Ο

-NH - C-CH-/ / - \ ff / \

CH, CH — C — Ν Ο, / \ _ / ff Λ ~ \

-CH — C — Ν Me — Me, _ / // (in which R represents a hydrogen atom or a substituent of an aryl group), —ch ₃ , —ch _{2 and 3} ,

-ch ₂ ch ₂ ck ₃ , —ch ₂ ck ₂ ch ₂ ch ₃ , —CH (ch ₃ ) ₂ , —ch ₂ -ch (CH ₃ ) ₂ ,

CH-OH, CH-CO ₂ H, CH-OMe.

Also preferred are compounds of the formulas (Ia), (Ib), (Ic) and (Id) as defined above, wherein R ¹³ is a group

-N (R ⁸ ) -C (= O) -OR ⁹ , especially said group in which R ⁸ represents a hydrogen atom or a lower alkyl group (such as a methyl group) and R ⁹ represents a lower alkyl group (such as a methyl group) aryl) (such as optionally substituted phenyl), heteroaryl (such as pyridyl, isoxazolyl, triazolyl, pyrimidinyl, thiazolyl or pyrazolopyrimidinyl, each optionally substituted with one or more aryl substituents), an alkyl group substituted with an alkoxy group (such as -CH 2 -O-CH 2 -CH 2 -OCH 3), an alkyl group substituted with a carboxy group (such as -CH 2 -CH 2 -CO 2 H and -CH 2 -CH 2 -CH 2 -CO 2 H) or an alkyl group substituted with -NY ⁴ Y ⁴ (such as aminomethyl and morpholin-1-ylmethyl).

According to the present invention are particularly preferred compounds of the above defined compounds of formulas (Ia), (Ib), (Ic) and (Id) in which R @ ⁴ represents ^a group -N ^(R8) -C (= 0) -R ⁹ , wherein R ⁹ is a substituted phenyl group selected from the group consisting of

2-chlorophenyl, 5-chloro-2-cyanophenyl, 2-chloro-6-methylphenyl, 2,6-dichlorophenyl, 2,6-difluorophenyl,

4-fluoro-2-trifluoromethyl,

2-methyl-4-nitrophenyl,

2-methyl-5-nitrophenyl, 2-nitrophenyl,

3-nitrophenyl or 2-phenoxyphenyl.

According to the present invention are also particularly preferred compounds of the above defined compounds of formulas (Ia), (Ib), (Ic) and (Id) in which R @ ⁴ represents ^a group -N ^(R8) -C (= 0) - R ⁹ wherein R ⁹ is an optionally substituted heteroaryl group selected from quinolin-4-yl, isoquinolin-2-yl, 2,4-pyridin-3-yl,

2,6-dimethyl-4-trifluoromethylpyridin-3-yl,

4-trifluoromethylpyridin-3-yl,

2-phenyl-4-methyl-1,2,3-triazol-5-yl,

3,5-dimethylisoxazol-4-yl,

2.7-dimethylpyrazolo [1,5-a] pyrimidin-6-yl, *, -, -, -, - * · «· ··· 9 4 9 9 10 9 94 9 9 4 ·

2-isopropyl-4-methylthiazol-5-yl; and 4-trifluoromethylpyrimidin-5-yl.

Particularly preferred compounds of the present invention are those selected from the linkage of the acyl carbon atom (C *) of one of the residues (A1 to A34) listed in Table 1 below to the nitrogen atom (N *) of one of the aza- bicyclic radicals (B1 to B6) listed in Table 2 and by attaching a carbon atom (C *) to the phenyl ring of one of the aza-bicyclic radicals (B1 to B6) listed in Table 2 to a carbon atom (C *) one of the acidic residues (C1 to C59) listed in Table 3 below.

-81 99 9 9 9 999 999

TABLE 1

-82TABLE 1 (continued)

-83 • «· · · ··

9 · · 4,444 «··

444 44 44,999,999,999

TABLE 1 (continued)

-849 9 9

9 99 9

999 · 9,999,999 9

TABLE 2

B1 > - ° WA. * \ / B2 y— ° * \ / \ = C * B3 ° in A ' ^CH 3, -N B4 Ν— ^X C * K V <2 * * \ / B5 0 χ — ch ₂ ch ₂ co ₂ h yN B6 0 y-CH ₂ CH ₂ NMe ₂ yN i_K N- (ζ ^ C *) B7 O-OCMe ₃ / -NN- B8 H y-N N-V ^ C * * \ /

-85 • O ·· 4 44

4 4 4 44 44 444 44 4

TABLE 3

Cl * CH — CH — CO ₂ H C2 * CH — CH — CO, H 1 ² ch ₃ C3 * CH — CH — CO-H 1 ^{2 2} ch ₂ ch ₃ C4 * CH — CH — CO, H 1 (CH ₂ ) ₃ CH ₃ C5 * CH — CH — COH 1 ^{2 2} CH (CH ₃ ) ₂ C6 * CH-CH-CO, H 1 CH ₂ CH (CH ₃ ) ₂ C7 * CH- C -CH 2 - CO, H C8 * CH- F -CH-CO, H ² C9 * CH- O -CH-CO ₂ H CIO * CH- 1 -CH-CO ₂ H Target * CH - CH - CO, H 0 02 / * CH — CH — CO, H \ / C 03 / _from CH - CO ₂ H * C. O 04 / * CH — CH — CO, H 1 CH ₂ CO ₂ H 05 / * CH — CH — CO, H 1 ^{2 2} o 06 / * CH — CH — CO, H and ^{2 20} .

· · · · · · · · · · · · · · · · · · · · · ·

-86TABLE 3 (continued) ··· ·· ·············

-87TABLE 3 (continued)

• 99 9 99 9 4 99 4 9 «99 9 44 4 99 9 999 99 99 949 98 49 9

• • •

-88 • · · · ·

TABLE 3 (continued)

-89TABLE 3 (continued)

· * K and • ·

-90TABLE 3 (continued)

C59 * CH ~ CH ' -CH-CO ₂ H C60 * ch ~ ch — every ₂ h C61 C62 * CH — CH — CO-H 1 * CH — CH — CO ₂ H HN ^ O Γ O ΓΪ1 W C63 * CH-CH-CO ₂ H C64 1 * C-CH-CO, H HN. 3 j 2 2 ! <· ^O ch ₃ C65 * CH — CH — CO ₂ H C66 * CH — CH — CO ₂ H and ch ₃ and ch ₃ C67 * CH — CH — CO ₂ H C68 * CH — CH — CO ₂ H HH ^ O —W • // \ o o ch ₃ ch ₃

Particular compounds of the invention are the following:

A1-B1-C1;

A1-B1-C2;

A1-B1-C3;

A1-B1-C4;

A1-B1-C5;

A1-B1-C6;

A1-B1-C7;

A1-B1-C8;

A1-B1-C9;

A1-B1-C10;

A1-B1-C11;

A1-B1-C12;

A1-B1-C13;

A1-B1-C14;

A1.B1-C15;

A1-B1-C16;

A1-B1-C17;

A1-B1-C18;

A1-B1-C19;

A1-B1-C20;

A1-B1-C21;

A1-B1-C22;

A1-B1-C23;

A1-B1-C24;

A1-B1-C2S;

A1-B1-C26;

A1-B1-C27;

A1-B1-C28;

A1-B1-C29;

A1-B1-C30;

A1-B1-C31;

A1-B1-C32;

A1-B1-C33;

A1-B1-C34;

A1-B1-C35;

A1-B1-C36;

A1-B1-C37;

A1-B1-C38;

A1-B1-C39;

A1-B1-C40;

A1-B1-C41;

A1-B1-C42;

AX-B1-C44;

A1-B1-C44;

A1-B1-C45;

A1-B1-C46;

A1-B1-C47;

A1-B1-C48;

A1-B1-C49;

A1-B1-C50;

A1-B1-C51;

A1-B1-C52;

A1-B1-C53;

A1-B1-C54;

A1-B1-C55;

A1-B1-C56;

A1-B1-C57;

A1-B1-C58;

A1-B1-C59;

A1-B1-C60;

A1-B1-C61;

A1-B1-C62;

A1-B1-C63;

A1-B1-C64;

A1-B1-C65;

A1-B1-C66;

A1-B1-C67;

A1-B1-C68;

A2-B1-C1;

A2-B1-C2;

A2-B1-C3;

A2-B1-C4;

A2-B1-C5;

A2-B1-C6;

A2-B1-C7;

A2-B1-C8;

A2-B1-C9;

A2-B1-C10;

A2-B1-C11;

A2-B1-C12;

A2-B1-C13;

A2-B1-C14;

A2-B1-C15;

A2-B1-C16;

A2-B1-C17;

A2-B1-C18;

A2-B1-C19;

A2-B1-C20;

A2-B1-C21;

A2-B1-C22;

A2-B1-C23;

A2-B1-C24;

A2-B1-C25;

A2-B1-C26;

A2-B1-C27;

A2-B1-C28;

A2-B1-C29;

A2-B1-C30;

A2-B1-C31;

A2-B1-C32;

A2-B1-C33;

A2-B1-C34;

A2-B1-C35;

A2-B1-C36;

A2-B1-C37;

A2-B1-C38;

A2-B1-C39;

A2-B1-C40;

A2-B1-C41;

A2-B1-C42;

A2-B1-C43;

A2-B1-C44;

A2-B1-C45;

A2-B1-C46;

A2-B1- C47;

A2-B1-C48;

A2-B1- C49;

A2-B1-C50;

A2-B1-C51;

A2-B1-C52;

A2-B1-C53;

A2-B1-C54;

A2-B1-C55;

A2-B1-C56;

A2-B1-C57;

A2-B1- C58;

A2-B1-C59;

A2-B1-C6O;

A2-B1-C61;

A2-B1- C62;

A2-B1-C63;

A2-B1-C64;

A2-B1-C65;

A2-B1-C66;

A2-B1-C67;

A2-B1- C68;

A3-B1-C1;

A3-B1-C2;

A3-B1-C3;

A3-B1-C4;

A3-B1-C8;

A3-B1-C6;

A3-B1-C8;

A3-B1-C7;

A3-B1-C9;

A3-B1-C10;

A3-B1-C12;

A3-B1-C12;

A3-B1-C13;

A3-B1-C14;

A3-B1-C15;

A3 - B1 - C16;

A3-B1-C17;

A3-B1-C18;

A3-B1-C19;

A3-B1-C20;

A3-B1-C21;

A3-B1-C22;

A3-B1-C23;

A3-B1-C24;

A3-B1-C25;

A3-B1-C26;

A3-B1- C27;

A3-B1-C28;

A3-B1-C29;

A3-B1-C30; A3-B1-C63; A4-B1-C28; A4-B1- C61; A5-B1-C26; A3-B1-C30; A3-B1-C64; A4-B1-C29; A4-B1- C62; A5-B1-C27; A3-B1-C32; A3-B1-C65; A4-B1-C30; A4-B1- C63; A5-B1-C28; A3-B1-C33; A3-B1-C66; A4-B1-C30; A4 - B1 - C64; A5-B1-C29; A3-B1-C34; A3-B1-C67; A4-B1-C33; A4-BI-C65; A5-B1-C30; A3-B1-C35; A3-B1-C68; A4-B1-C33; A4-B1-C66; A5-B1-C31; A3-B1-C36; A4-B1-C1; A4-B1-C33; A4-B1- C67; A5-B1-C32; A3-B1-C37; A4-B1-C2; A4-B1-C35; A4-B1- C68; A5-B1-C33; A3-B1-C38; A4-B1-C3; A4-B1-C36; A5-B1-C1; A5-B1-C34; A3-B1-C39; A4-B1-C4; A4-B1-C37; A5-B1-C2; A5-B1-C35; A3-B1-C40; A4-B1-C4; A4-B1-C38; A5-B1-C3; A5-B1-C36; A3-B1-C41; A4-B1-C6; A4-B1-C39; A5-B1-C4; A5-B1-C37; A3-B1-C42; A4-B1-C8; A4-B1-C40; A5-B1-C5; A5-B1-C38; A3-B1-C44; A4-B1-C7; A4-BI-C41; A5-B1-C6; A5-B1-C39; A3-B1-C44; A4-B1-C9; A4-B1-C42; A5-B1-C7; A5-B1-C40; A3-B1-C45; A4-B1-C10; A4-B1- C43; A5-B1-C8; A5-B1-C41; A3-B1-C46; A4-B1-C12; A4-B1-C44; A5-B1-C9; A5-B1-C42; A3-B1- C47; A4-B1-C12; A4-B1-C45; A5-B1-C10; A5-B1-C43; A3-B1-C48; A4-B1-C14; A4-B1- C46; A5-B1-C11; A5-B1-C44; A3-B1-C50; A4-B1-C14; A4-B1- C47; A5-B1-C12; A5-B1-C45; A3-B1-C50; A4 - B1 - C15; A4-B1- C48; A5-B1-C13; A5-B1-C46; A3-B1-C51; A4 - B1 - C16; A4-B1- C49; A5-B1-C14; A5-B1- C47; A3-B1-C52; A4-B1-C18; A4-B1-C50; A5-B1-C15; A5-B1-C48; A3-B1-C53; A4-B1-C18; A4-B1-C51; A5-B1-C16; A5-B1-C49; A3-B1-C54; A4-B1-C19; A4-B1-C52; A5-B1-C17; A5-B1-C50; A3-B1-C55; A4-B1-C20; A4-B1-C53; A5-B1-C18; A5-B1-C51; A3-B1-C55; A4-B1-C21; A4-B1-C54; A5-B1-C19; A5-B1-C52; A3-B1-C57; A4-B1-C22; A4-B1-C55; A5-B1-C20; A5-B1-C53; A3-B1-C58; A4-B1-C23; A4-B1-C55; A5-B1-C21; A5-B1-C54; A3-B1-C59; A4-B1-C24; A4 - B1 - C57; A5-B1-C22; A5-B1-C55; A3-B1-C60; A4-B1-C25; A4-B1- C58; A5-B1-C23; A5-B1-C56; A3-B1-C61; A4-B1-C26; A4-B1-C59; A5-B1-C24; A5-B1-C57; A3-B1- C62; A4-B1- C27; A4-BI-C60; A5-B1-C25; A5-B1-C58;

-93 · · · · · · · · · · · · · · · · ·

A5-B1-C59;

A5-B1-C60;

A5-B1-C61;

A5-B1- C62;

A5-B1-C63;

A5-B1-C64;

A5-B1-C65;

A5-B1-C66;

A5-B1-C67;

A5-B1-C68;

A6-B1-C1;

A6-B1-C2;

A6-B1-C3;

A6-B1-C4;

A6-B1-C5;

A6-B1-C6;

A6-B1-C8;

A6-B1-C8;

A6-B1-C9;

A6-B1-C10;

A6-BI-C11;

A6-B1-C12;

A6-B1-C13;

A6-B1-C14;

A6-B1-C15;

A6-B1-C16

A6-B1-C17;

AND

A6-B1-C18;

A6-B1-C19;

A6-B1-C20;

A6-B1-C21;

A6-B1-C22;

A6-B1-C23;

A6-B1-C24;

A6-B1-C2S;

A6-B1-C26;

A6-B1-C27;

A6-B1-C28;

A6-B1-C29;

A6-B1-C30;

A6-B1-C30;

A6-B1-C32;

A6-B1-C33;

A6-B1-C34

A6-B1-C35;

A6-B1-C36;

A6-B1-C37;

A6-B1-C38;

A6-B1-C39;

A6-B1-C40;

A6-B1-C41;

A6-B1-C42;

A6-B1-C43

A6-B1-C44;

A6-B1-C45;

A6-B1-C46;

A6-B1-C47;

A6-B1-C48;

A6-B1-C49

A6-B1-C50;

A6-B1-C51;

A6-B1-C52

A6-B1-C53;

A6-B1-C54

A6-B1-C55

A6-B1-C55;

A6-B1-C57;

A6-B1-C58;

A6-B1-C59;

A6-B1-C60;

A6-B1-C61;

A6-B1-C62;

A6-B1-C63;

A6-B1-C64

A6-B1-C65;

A6-B1-C66;

A6-B1-C67;

A6-B1-C68

A7-B1-C1;

A7-B1-C2;

A7-B1-C3;

A7-B1-C4;

A7-B1-C5;

A7-B1-C6;

A7-B1-C7;

A7-B1-C8;

A7-B1-C9;

A7-B1-C10;

A7-B1-C11;

A7-B1-C12;

A7-B1-C13;

A7-B1-C14;

A7-B1-C15;

A7-B1-C16;

A7-B1-C17;

A7-B1-C18;

A7-B1-C19;

A7-B1-C20;

A7-B1-C21;

A7-B1-C22;

A7-B1-C23;

A7-B1-C24;

A7-B1-C25;

A7-B1-C26;

A7-B1-C27;

A7-B1-C28;

A7-B1-C29;

A7-B1-C30;

A7-B1-C31;

A7-B1-C32;

A7-B1-C33;

A7-B1-C34;

A7-B1-C35;

A7-B1-C36;

A7-B1-C37;

A7-B1-C38;

A7-B1-C39;

A7-B1-C40;

A7-B1-C41;

A7-B1-C42;

A7-B1-C43;

A7-B1-C44;

A7-B1-C45;

A7-B1-C46;

A7-B1-C47;

A7-B1-C48;

A7-B1-C49;

A7-B1-C50;

A7-B1-C51;

A7-B1-C52;

A7-B1-C53;

A7-B1-C54;

A7-B1-C55;

A7-B1-C56;

A7-B1-C57;

A7-B1-C58;

A7-B1-C59;

A7-B1-C60;

A7-B1-C61;

A7-B1-C62;

A7-B1-C63;

A7-B1-C64;

A7-B1-C65;

A7-B1-C66;

A7-B1-C67;

A7-B1-C68;

A8-B1-C1;

A8-B1-C2;

A8-B1-C3;

A8-B1-C4;

A8-B1-C8;

A8-B1-C6;

A8-B1-C7;

A8-B1-C8;

A8-B1-C9;

A8-B1-C10;

A8-B1-C11;

A8-B1-C12;

A8-B1-C13;

A8-B1-C14;

A8-B1-C15;

A8-B1-C16;

A8-B1-C17;

A8-B1-C18;

A8-B1-C19;

-94 • ·· ·· 4 ·· • «4 4444 4« · • 44 4 4

445 4 4 «» «

A8-B1-C20; A8-B1-C53; A9-B1-C18; A9-B1-C51; A10-B1-C16; A8-B1-C21; A8-B1-C54; A9-B1-C19; A9-B1-C52; A10-B1-C17; A8-B1-C22; A8-B1-C55; A9-B1-C20; A9-B1-C53; A10-B1-C18; A8-B1-C23; A8-B1-C56; A9-BI-C21; A9-B1-C54; A10-BI-C19; A8-B1-C24; A8-B1-C57; A9-B1-C22; A9-B1-C55; A10-B1-C20; A8-B1-C25; A8-B1-C58; A9-B1-C23; A9-B1-C56; A10-B1-C21; A8-B1-C26; A8-B1-C59; A9-B1-C24; A9-B1-C57; A10-B1-C22; A8-B1-C27; A8-B1-C60; A9-B1-C25; A9-B1-C58; A10-B1-C23; A8-B1-C28; A8-B1-C61; A9-B1-C26; A9-B1-C59; A10-B1-C24; A8-B1-C29; A8-B1-C62; A9-B1-C27; A9-B1-C60; A10-B1-C25; A8-B1-C30; A8-B1-C63; A9-B1-C28; A9-B1-C61; A10-B1-C26; A8-B1-C31; A8-B1-C64; A9-B1-C29; A9-B1-C62; A10 - B1 - C27; A8-B1-C32; A8-B1-C65; A9-B1-C30; A9-B1-C63; A10-B1-C28; A8-B1-C33; A8-B1-C66; A9-B1-C31; A9-B1-C64; A10-B1-C29; A8-B1-C34; A8-B1-C67; A9-B1-C32; A9-B1-C65; A10-B1-C30; A8-B1-C35; A8-B1-C68; A9-B1-C33; A9-B1-C66; A10-B1-C30; A8-B1-C36; A9-B1-C1; A9-B1-C34; A9-B1-C67; A10-B1-C32; A8-B1-C37; A9-B1-C2; A9-B1-C35; A9-B1-C68; A10-B1-C33; A8-B1-C38; A9-B1-C3; A9-BI-C36; A10-B1-C1; A10-B1-C34; A8-B1-C39; A9-B1-C4; A9-B1-C37; A10-B1-C2; A10 - B1 - C35; A8-B1-C40; A9-B1-C5; A9-B1-C38; A10-B1-C3; A10-B1-C36; A8-B1-C41; A9-B1-C6; A9-B1-C39; A10-B1-C4; A10-B1-C37; A8-B1-C42; A9-B1-C7; A9-B1-C40; A10-B1-C8; A10-B1-C38; A8-B1-C43; A9-B1-C8; A9-B1-C41; A10-B1-C6; A10-B1-C39; A8-B1-C44; A9-B1-C9; A9-B1-C42; A10-B1-C8; A10-B1-C40; A8-B1-C45; A9-B1-C10; A9-B1-C43; A10-B1-C8; A10-B1-C41; A8-B1-C46; A9-B1-C11; A9-B1-C44; A10-B1-C9; A10-B1-C42; A8-B1-C47; A9-B1-C12; A9-B1-C45; A1O-B1-C1O; A10-B1-C44; A8-B1-C48; A9-B1-C13; A9-B1-C46; A10-B1-C11; A10-BI-C44; A8-B1-C49; A9-B1-C14; A9-B1-C47; A10-B1-C12; A10-B1-C45; A8-B1-C50; A9-B1-C15; 99-BI-C48; A10-B1-CI3; A1-B1-C46; A8-B1-C51; A9-B1-C16; A9-B1-C49; A10-B1-C14; A10-B1- C47; A8-B1-C52; A9-B1-C17; A9-B1-C50; A10 - B1 - C15; A10-B1-C48;

* ·

-95 · «···· · · · · · · ·

A10-B1-C50; A11-B1-C14; A11-B1- C47; A12-B1-C12; A12-B1-C45; A10-B1-C50; A11-B1-C15; A11-B1-C48; A12-B1-C13; A12-B1-C46; A10-B1-C51; A11 - B1 - C16; A11-B1-C50; A12-B1-C14; A12-B1- C47; A10-B1-C52; A11-B1-C17; A1I-B1-C50; A12-B1-C15; A12-B1-C48; A10-B1-C53; A11-B1-C18; A11-B1-C51; A12-B1-C16; A12-B1- C49; A10 - B1 - C54; A11-B1-C19; A11-B1-C52; A12-B1-C17; A12-B1-C50; A10-B1-C55; A11-B1-C20; A11-B1-C53; A12-B1-C18; A12-B1-C51; A10-B1-C55; A11-B1-C21; A11-B1-C54; A12-B1-C19; A12-B1-C52; A10-B1-C57; A11-B1-C22; A11-B1-C55; A12-B1-C20; A12-B1-C53; A10 - B1 - C58; A11-B1-C23; A11-B1-C55; A12-B1-C21; A12-B1-C54; A10-B1-C59; A11-B1-C24; A11-B1-C57; A12-B1-C22; A12-B1-C55; A10-B1-C60; A11-B1-C25; A11-B1-C58; A12-B1-C23; A12-B1-C55; A10-B1-C61; A11-B1-C26; A11-B1-C59; A12-B1-C24; A12-B1-C57; A10-B1-C62; A11 - B1 - C27; A11-B1-C60; A12-B1-C25; A12-B1-C58; A10-B1-C63; A11-B1-C28; A11-B1-C61; A12-B1-C26; A12-B1-C59; A10 - B1 - C64; A11-B1-C29; A11-B1-C62; A12-B1- C27; A12-B1-C60; A10-B1-C65; A11-B1-C30; A11-B1-C63; A12-B1-C28; A12-B1-C61; A10-B1-C66; A11-B1-C30; A11-B1-C64; A12-B1-C29; A12-B1-C62; A10-B1-C67; A11-B1-C32; A11-B1-C65; A12-B1-C30; A12-B1-C63; A10-B1-C68; A11-B1-C33; A11-B1-C66; A12-B1-C30; A12-B1-C64; A11-B1-C1; A11-B1-C34; A11-B1-C67; A12-B1-C32; A12-B1-C65; A11-B1-C2; AU-B1-C35; A11-B1-C68; A12-B1-C33; A12-B1-C66; A11-B1-C3; A11-B1-C36; A12-B1 Cl; A12-B1-C34; A12-B1-C67; A11-B1-C4; A11-B1-C37; A12-B1-C2; A12-B1-C35; A12-B1- C68; A11-B1-C8; A11-B1-C38; A12-B1-C3; A12-B1-C36; A13-B1-C1; A11-B1-C6; A11-B1-C39; A12-B1-C4; A12-B1-C37; A13-B1-C2; A11-B1-C8; A11-B1-C40; A12-B1-C4; A12-B1-C38; A13-B1-C3; A11-B1-C7; A11-B1-C41; A12-B1-C6; A12-B1-C39; A13-B1-C4; A11-B1-C9; A11-B1-C42; A12-B1-C8; A12-B1-C40; A13-B1- C5; A11-B1-C10; A11-B1-C43; A12-B1-C7; A12-B1-C41; A13-B1-C6; A11-B1-C11; A11-B1-C44; A12-B1-C9; A12-B1-C42; A13-B1-C7; A11-B1-C12; A11-B1-C45; A12-B1-C10; Al2-BI-C43; A13-B1-C8; A11-B1-C13; A11-B1-C46; A12-B1-C11; A12-B1-C44; A13-B1-C9;

-96A13-B1-C10;

A13-B1-C11;

A13-B1-C12;

A13-B1-C13;

A13-B1-C14;

A13-B1-C15;

A13-B1-C16;

A13-B1-C17;

A13-B1-C18;

A13-B1-C19;

A13-B1-C20;

A13-B1-C21;

A13-B1-C22;

A13-B1-C23;

A13-B1-C24;

A13-B1-C25;

A13-B1-C26;

A13-B1- C27;

A13-B1-C28;

A13-B1-C29;

A13-B1-C30;

A13-B1-C31;

A13-B1-C32;

A13-B1-C33;

A13-BI-C34;

A13-B1-C35;

A13-B1-C36;

A13-B1-C37;

A13-B1-C38;

A13-B1-C39;

A13-B1-C40;

A13-B1-C41;

A13-B1-C42;

A13-B1-C43;

A13-B1-C44;

A13-B1-C45;

A13-B1-C46;

A13-B1- C47;

A13-B1-C48;

A13-B1-C49;

A13-B1-C50;

A13-B1-C51;

A13-B1-C52;

A13-B1-C53;

A13-B1-C54;

A13-B1-C55;

A13-B1-C56;

A13-B1-C57;

A13-B1-C58;

A13-B1-C59;

A13-B1-C60;

A13-B1-C61;

A13-B1-C62;

A13-B1-C63;

A13-B1-C64;

A13-B1-C65;

A13-B1-C66;

A13-B1-C67;

A13-B1-C68;

A14-B1-C1;

A14-B1-C2;

A14-B1-C3;

A14-B1-C4;

A14-B1- C5;

A14-BI-C6;

A14-B1-C8;

A14-B1-C7;

A14-B1-C9;

A14-B1-C10;

A14-B1-C12;

A14-B1-C12;

A14-B1-C13;

A14-B1-C14;

A14-B1- C15;

A14-B1- C16;

A14-B1-C17;

A14-B1-C18;

A14-B1-C19;

A14-B1-C20;

A14-B1-C21;

A14-B1-C22;

A14-B1-C23;

A14-B1-C24;

A14-B1-C25;

A14-B1-C26;

A14-B1- C27;

A14-B1-C28;

A14-B1-C29;

A14-B1-C30;

A14-B1-C30;

A14-B1-C32;

A14-B1-C33;

A14-B1-C34;

A14-B1- C35;

A14-B1-C36;

A14-B1- C37;

A14-B1-C38;

A14-B1-C39;

A14-B1-C40;

A14-B1-C41;

A14-B1-C42;

A14-B1- C43;

A14-B1-C44;

A14-B1-C45;

A14-B1- C46;

A14-B1- C47;

A14-B1-C48;

A14-B1-C49;

A14-B1-C50;

A14-B1-C51;

A14-B1- C52;

A14-B1-C53;

A14-B1-C54;

A14-B1-C55;

A14-B1-C55;

A14-B1- C57;

A14-B1-CS7;

A14-B1- C59;

A14-B1-C60;

A14-B1-C61;

A14-B1- C62;

A14-B1-C63;

A14-B1-C64;

A14-B1-C65;

A14-B1-C66;

A14-B1-C67;

A14-B1- C68;

A15-B1-C1;

A15-B1-C2;

A15-B1-C3;

A15-B1-C4;

A15-B1-C8;

A15-B1-C6;

A15-B1-C8;

A15-B1-C7;

A15-B1-C9;

A15-BI-C10;

A15-B1-C11;

A15-B1-C12;

A15-B1-C13;

A15-B1-C14;

A15 - B1 - C15;

A15 - B1 - C16;

A15-B1-C17;

A15-B1-C18;

A15-B1-C19;

A15-B1-C20;

A15-B1-C21;

A15-B1-C22;

A15-B1-C23;

A15-B1-C24;

A15-B1-C25;

A15-B1-C26;

A15-B1- C27;

A15-B1-C28;

A15-B1-C29;

A15-B1-C30;

A15-B1-C30;

A15-B1-C32;

A15-B1-C33;

A15-B1-C34;

A15-B1-C35;

A1S-B1-C36;

A15-B1-C37;

A15-B1-C38;

-91 • 9 9 9 • 9 3 3

A15-B1-C39;

A15-B1-C40;

A15-B1-C41;

A15-B1-C42;

A15-B1- C43;

A15-B1-C44;

A15-B1-C45;

A15-B1-C46;

A15-B1- C47;

A15-B1-C48;

A15-B1-C50;

A15-B1-C50;

A15-B1-C51;

A15-B1-C52;

A15-B1-C53;

A15-B1-C54;

A15-B1-C55;

A15-B1-C55;

A15-B1-C57;

A15-B1-C58;

A15-B1-C59;

A15-B1-C60;

A15-B1-C61;

A15-B1-C62;

A15-B1-C63;

A15-B1-C64;

A15-BI-C65;

ί

A15-B1-C66;

A15-B1-C67;

A15-B1-C68;

A16-B1-C1;

A16-B1-C2;

A16-B1-C3;

A16-B1-C4;

A16-B1-C4;

A16-B1-C6;

A16-B1-C8;

A16-B1-C8;

A16-B1-C9;

A16-B1-C10;

A16-B1-CU;

A16-B1-C12;

A16 - B1 - C13;

A16-B1-C14;

A16 - B1 - C15;

A16 - B1 - C16;

A16 - B1 - C17;

A16 - B1 - C18;

A16-B1-C19;

A16-B1-C20;

A16-B1-C21;

A16-B1-C22;

A16-B1-C23;

A16-B1-C24;

A16-B1-C25;

A16-B1-C26;

A16 - B1 - C27;

A16-B1-C28;

A16-B1-C29;

A16-B1-C30;

A16-B1-C30;

A16 - B1 - C32;

A16-B1-C33;

A16-B1-C34;

A16 - B1 - C35;

A16-B1-C36;

A16-B1-C37;

A16-B1-C38;

A16-B1-C39;

A16-B1-C40;

A16-BI-C41;

A16-B1-C42;

Al6-B1-C43;

A16-B1-C44;

A16-B1-C45;

A16 - B1 - C46;

A16 - B1 - C47;

A16-B1-C48;

A16-B1-C50;

A16-B1-C50;

A16-B1-C51;

A16-B1-C52;

A16-B1-C53;

A16 - B1 - C54;

A16-B1-C55;

A16-B1-C55;

A16-B1-C57;

A16 - B1 - C58;

A16-B1-C59;

A16-B1-C60;

A16 - B1 - C61;

A16 - B1 - C62;

A16-B1-C63;

A16 - B1 - C64;

A16-B1-C65;

A16-B1-C66;

A16-B1-C67;

A16-B1-C68;

A17-B1-C1;

A17-B1-C2;

A17-B1-C3;

A17-B1-C4;

A17-B1-C8;

A17-B1-C6;

A17-B1-C8;

A17-B1-C7;

A17-B1-C9;

A17-B1-C10;

A17-B1-C12;

A17-B1-C12;

A17-B1-C13;

A17-B1-C14;

A17 - B1 - C15;

A17 - B1 - C16;

A17 - B1 - C17;

A17-B1-C18;

A17-B1-C19;

A17-B1-C20;

A17-B1-C21;

A17-B1-C22;

A17-B1-C23;

A17-B1-C24;

A17-B1-C25;

A17-B1-C26;

A17 - B1 - C27;

A17-B1-C28;

A17-B1-C29;

A17-B1-C30;

A17-B1-C30;

A17-B1-C32;

A17-B1-C33;

A17-B1-C34;

A17-B1-C35;

A17-B1-C36;

A17-B1-C37;

A17-BI-C38;

A17-B1-C39;

A17-B1-C40;

A17-B1-C41;

A17-B1-C42;

A17-B1-C44;

A17-B1-C44;

A17-B1-C45;

A17-B1-C46;

A17-B1-C47;

A17-B1-C48;

A17-B1-C49;

A17-B1-C50;

A17-B1-C51;

A17-B1-C52;

A17-B1-C53;

A17-B1-C54;

A17-B1-C55;

A17-B1-C55;

A17-B1-C57;

A17-B1-C58;

A17-B1-C59;

A17-B1-C60;

A17-B1-C61;

A17-B1-C62;

A17-B1-C63;

A17-B1-C64;

A17-B1-C65;

A17-B1-C66;

A17-B1-C67;

·· ►

··· ·· ·· ·· ·

A17-B1-C68;

A18-B1-C1;

A18-B1-C2;

A18-B1-C3;

A18-B1-C4;

A18-B1- C5;

A18-B1-C6;

A18-B1-C8;

A18-B1-C8;

A18-B1-C9;

A18-B1-C10;

A18-B1-C11;

A18-B1-C12;

A18-B1-C13;

A18-B1-C14;

A18-B1-C15;

A18-B1-C16;

A18-B1-C17;

A18-B1-C18;

A18-B1-C19;

A18-B1-C20;

A18-B1-C21;

A18-B1-C22;

A18-B1-C23;

A18-B1-C24;

A18-B1-C25;

A18-B1-C26;

AND

A18-B1- C27;

A18-B1-C28;

A18-B1-C29;

A18-B1-C30;

A18-B1-C30;

A18-B1-C32;

A18-BI-C33;

A18-B1-C34;

A18-B1-C35;

A18-B1-C36;

A18-B1-C37;

A18-B1-C38;

A18-BI-C39;

A18-B1-C40;

A18-B1-C41;

A18-B1-C42;

A18-B1-C44;

A18-B1-C44;

A18-B1-C45;

A18-B1-C46;

A18-B1-C47;

A18-B1-C48;

A18-B1-C50;

A18-B1-C50;

A18-B1-C51;

A18-B1-C52;

A18-B1-C53;

A18-B1-C54;

A18-B1-C55;

A18-B1-C56;

A18-B1-C57;

A18-B1-C58;

A18-B1-C59;

A18-B1-C60;

A18-B1-C61;

A18-B1-C62;

A18-B1-C63;

A18-B1-C64;

A18-B1-C65;

A18-B1-C66;

A18-B1-C67;

A18-BI-C68;

A19-B1-C1;

A19-B1-C2;

A19-B1-C3;

A19-B1-C4;

A19-B1-C8;

A19-B1-C6;

A19-B1-C8;

A19-B1-C7;

A19-B1-C9;

A19-B1-C10;

A19-B1-C12;

A19-B1-C12;

A19-B1-C13;

A19-B1-C14;

A19-B1-C15;

A19-B1-C16;

A19-B1-C17;

A19-B1-C18;

A19-B1-C19;

A19-B1-C20;

A19-B1-C21;

A19-B1-C22;

A19-B1-C23;

A19-B1-C24;

A19-B1-C25;

A19-B1-C26;

A19-B1- C27;

A19-B1-C28;

A19-B1-C29;

A19-B1-C30;

A19-B1-C30;

A19-B1-C32;

A19-B1-C33;

A19-B1-C34;

A19-B1-C35;

A19-B1-C36;

A19-B1-C37;

A19-B1-C38;

A19-B1-C39;

A19-B1-C40;

A19-B1-C41;

A19-B1-C42;

A19-B1-C44;

A19-B1-C44;

A19-B1-C45;

A19-B1-C46;

A19-B1- C47;

A19-B1-C48;

A19-B1-C50;

A19-B1-C50;

A19-B1-C51;

A19-B1-C52;

A19-B1-C53;

A19-BI-C54;

A19-B1-C55;

A19-B1-C55;

A19-B1-C57;

A19-B1-C58;

A19-B1-C59;

A19-B1-C60;

A19-BI-C61;

A19-B1-C62;

A19-B1-C63;

A19-B1-C64;

A19-B1-C65;

A19-B1-C66;

A19-B1-C67;

A19-B1- C68;

A20-B1-C1;

A20-B1-C2;

A20-B1-C3;

A20-B1-C4;

A20-B1-C8;

A20-B1-C6;

A20-B1-C8;

A20-B1-C7;

A20-B1-C9;

A20-B1-C10;

A20-B1-C12;

A20-B1-C12;

A20-B1-C12;

A20-B1-C14;

A20-B1-C14;

A20-B1-C16;

A20-B1-C16;

A20-B1-C18;

A20-B1-C19;

A20-B1-C20;

A20-B1-C21;

A20-B1-C22;

A20-B1-C23;

A20-B1-C24;

A20-BI-C25;

A20-B1-C26;

A20-B1- C27;

A20-B1-C28;

-99 • ·································· · · · ···

A20-B1-C29; A20-B1- C62; A21-BI-C27; A21-B1-C60; A22-B1- C25; A20-B1-C30; A20-B1- C63; A21-B1-C28; A21-B1-C61; A22-B1-C26; A20-B1-C30; A20-B1- C64; A21-B1-C29; A21-B1-C62; A22-B1- C27; A20-B1-C30; A20-B1-C65; A21-B1-C30; A21-B1-C63; A22-B1- C28; A20-B1-C33; A20-B1-C66; A21-B1-C30; A21-B1-C64; A22-B1-C29; A20-B1-C33; A20-B1-C67; A21-B1-C32; A21-B1-C65; A22-B1-C30; A20-B1-C35; A20-B1- C68; A21-BI-C33; A21-B1-C66; A22-B1- C31; A20-B1-C36; A21-B1-C1; A21-B1-C34; A21-B1-C67; A22-B1-C32; A20-B1-C37; A21-B1-C2; A21-B1-C35; A21-B1-C68; A22-B1-C33; A20-B1-C38; A21-B1-C3; A21-B1-C36; A22-B1-C1; A22-B1-C34; A20-B1-C39; A21-B1-C4; A21-B1-C37; A22-B1-C2; A22-B1- C35; A20-B1-C40; A21-B1-C8; A21-B1-C38; A22-B1-C3; A22-B1-C36; A20-B1-C41; A21-B1-C6; A21-B1-C39; A22-B1-C4; A22-B1-C37; A20-B1-C42; A21-B1-C8; A21-B1-C40; A22-B1- C5; A22-B1-C38; A20-B1-C44; A21-B1-C8; A21-B1-C41; A22-B1-C6; A22-B1-C39; A20-B1-C44; A21-B1-C9; A21-B1-C42; A22-B1-C8; A22-B1-C40; A20-B1-C45; A21-B1-C10; A21-B1-C43; A22-B1-C8; A22-B1-C41; A20-B1-C46; A21-B1-C11; A21-B1-C44; A22-B1-C9; A22-B1-C42; A20-B1- C47; A21-B1-C12; A21-B1-C45; A22-B1-C10; A22-B1- C43; A20-B1-C48; A21-B1-C13; A21-B1-C46; A22-B1-C12; A22-B1-C44; A20-B1-C50; A21-B1-C14; A21-B1-C47; A22-B1-C12; A22-B1-C45; A20-B1-C50; A21-B1-C15; A21-B1-C48; A22-B1-C13; A22-B1- C46; A20-B1-C51; A21-B1-C16; A21-B1-C50; A22-B1-C14; A22-B1- C47; A20-B1-C52; A21-B1-C17; A21-B1-C50; A22-B1-C15; A22-B1-C48; A20-B1-C53; A21-B1-C18; A21-B1-C51; A22-B1-C16; A22-B1- C49; A20-B1-C54; A21-B1-C19; A21-B1-C52; A22-B1-C17; A22-B1-C50; A20-B1-C55; t A21-B1-C20; A21-B1-C53; A22-B1-C18; A22-B1-C51; A20-B1-C55; A21-B1-C21; A21-B1-C54; A22-B1-C19; A22-B1- C52; A20-B1-C57; A21-B1-C22; A21-B1-C55; A22-B1-C20; A22-B1-C53; A20-B1-C58; A21-B1-C23; A21-B1-C56; A22-B1-C21; A22-B1-C54; A20-B1- C59; A21-B1-C24; A21-B1-C57; A22-B1-C22; A22-B1-C55; A20-B1-C60; A21-B1-C25; A21-B1-C58; A22-B1-C23; A22-B1-C55; A20-B1-C60; A21-B1-C26; A21-B1-C59; A22-B1- C24; A22-B1-C57;

φ φ φ φ φ φ · · «« «

- 100 φ 100

A22-B1- C58;

A22-B1-C59;

A22-B1-C60;

A22-B1-C61;

A22-B1- C62;

A22-B1- C63;

A22-B1- C64;

A22-B1-C65;

A22-B1-C66;

A22-B1- C67;

A22-B1- C68;

A23-B1-C1;

A23-B1-C2;

A23-B1-C3;

A23-B1-C4;

A23-B1-C8;

A23-B1-C6;

A23-B1-C8;

A23-B1-C8;

A23-B1-C9;

A23-B1-C10;

A23-B1-C12;

A23-B1-C12;

A23-B1-C13;

A23-B1-C14;

A23-B1-C15;

A23-B1-C16;

A23-B1-C17;

A23-B1-C18;

A23-B1-C19;

A23-B1-C20;

A23-B1-C21;

A23-B1-C22;

A23-B1-C23;

A23-B1-C24;

A23-B1-C25;

A23-B1-C26;

A23-B1- C27;

A23-B1-C28;

A23-B1-C29;

A23-B1-C30;

A23-B1-C30;

A23-B1-C32;

A23-B1-C33;

A23-B1-C34;

A23-B1-C35;

A23-B1-C36;

A23-B1-C37;

A23-B1-C38;

A23-B1-C39;

A23-B1-C40;

A23-B1-C41;

A23-B1-C42;

A23-B1-C44;

A23-B1-C44;

A23-B1-C45;

A23-B1-C46;

A23-B1-C47;

A23-B1-C48;

A23-B1-C49;

A23-B1-C50;

A23-B1-C51;

A23-B1-C52;

A23-B1-C53;

A23-B1-C54;

A23-B1-C55;

A23-B1-C55;

A23-B1-C57;

A23-B1-C58;

A23-B1-C59;

A23-B1-C60;

A23-B1-C61;

A23-B1-C62;

A23-B1-C63;

A23-B1-C64;

A23-BI-C65;

A23-B1-C66;

A23-B1-C67;

A23-B1-C68;

A24-B1-C1;

A24-B1-C2;

A24-B1-C3;

A24-B1-C4;

A24-B1-C8;

A24-B1-C6;

A24-B1-C8;

A24-B1-C7;

A24-B1-C9;

A24-B1-C10;

A24-B1-C12;

A24-B1-C11;

A24-B1-C12;

A24-B1-C14;

A24-B1-C14;

A24-B1-C16;

A24-B1-C18;

A24-B1-C18;

A24-B1-C19;

A24-B1-C20;

A24-B1-C21;

A24-B1-C22;

A24-B1-C23;

A24-B1-C24;

A24-B1-C25;

A24-B1-C26;

A24-B1- C27;

A24-B1-C28;

A24-B1-C29;

A24-B1-C30;

A24-B1-C30;

A24-B1-C32;

A24-B1-C33;

A24-B1-C33;

A24-B1-C35;

A24-B1-C36;

A24-B1-C37;

A24-B1-C38;

A24-B1-C39;

A24-B1-C40;

A24-B1-C41;

A24-B1-C42;

A24-B1-C44;

A24-B1-C44;

A24-B1-C45;

A24-B1-C46;

A24-B1-C47;

A24-B1-C48;

A24-B1-C49;

A24-B1-C50;

A24-B1-C51;

A24-B1-C52;

A24-B1-C53;

A24-BI-C54;

A24-B1-C55;

A24-B1-C55;

A24-B1-C57;

A24-B1-C58;

A24-BI-C59;

A24-B1-C60;

A24-B1-C6I;

A24-B1-C62;

A24-B1-C63;

A24-B1-C64;

A24-B1-C65;

A24-B1-C66;

A24-B1-C67;

A24-B1- C68;

A25-B1-C1;

A25-B1-C2;

A25-B1-C3;

A25-B1-C4;

A25-B1-C8;

A25-B1-C6;

A25-B1-C8;

A25-B1-C7;

A25-B1-C9;

A25-B1-C10;

A25-B1-C12;

A25-B1-C12;

A25-B1-C12;

A25-B1-C14;

A25 - B1 - C15;

A25-BI-C16;

A25-B1-C16;

A25-B1-C18;

- 101 • * 9 9 * «* · • 9 * 9 9 99 99 99

98 9 9 9 9 9

999 999 99 *. 99 99 999 99 9

A25-B1-C19;

A25-B1-C20;

A25-B1-C21;

A25-B1-C22;

A25-B1-C23;

A25-B1-C24;

A25-B1-C25;

A25-B1-C26;

A25 - B1 - C27;

A25-B1-C28;

A25-B1-C29;

A25-B1-C30;

A25-B1-C30;

A25-B1-C33;

A25-B1-C33;

A25-B1-C33;

A25-B1-C35;

A25-B1-C36;

A25-B1-C37;

A25-B1-C38;

A25-B1-C39;

A25-B1-C40;

A25-B1-C41;

A25-B1-C42;

A25 - B1 - C43;

A25-B1-C44;

A25-B1-C45;

A25 - B1 - C46;

A25 - B1 - C47;

A25-B1-C48;

A25-B1-C50;

A25-B1-C50;

A25-B1-C51;

A25-B1-C52;

A25-B1-C53;

A25 - B1 - C54;

A25-B1-C55;

A25-B1-C55;

A25-B1-C57;

A25-B1-C58;

A25-B1-C59;

A25-B1-C60;

A25-B1-C60;

A25-B1- C62;

A25-B1-C63;

A25-B1- C64;

A25-B1-C65;

A25-B1-C66;

A25-B1-C67;

A25-B1-C68;

A26-B1-C1;

A26-B1-C2;

A26-B1-C3;

A26-B1-C4;

A26-B1-C8;

A26-B1-C6;

A26-B1-C8;

A26-B1-C7;

A26-B1-C8;

A26-B1-C10;

A26-B1-C12;

A26-B1-C11;

A26-B1-C12;

A26-B1-C14;

A26 - B1 - C15;

A26 - B1 - C16;

A26 - B1 - C17;

A26 - B1 - C18;

A26-B1-C19;

A26-B1-C20;

A26-B1-C21;

A26-B1-C22;

A26-B1-C23;

A26 - B1 - C24;

A26 - B1 - C25;

A26-B1-C26;

A26 - B1 - C27;

A26-B1-C28;

A26-B1-C29;

A26-B1-C30;

A26-B1-C30;

A26 - B1 - C32;

A26 - B1 - C33;

A26-B1-C33;

A26 - B1 - C35;

A26-B1-C36;

A26 - B1 - C37;

A26-B1-C38;

A26-B1-C39;

A26-B1-C40;

A26-BI-C41;

A26 - B1 - C42;

A26-B1-C44;

A26-B1-C44;

A26 - B1 - C45;

A26 - B1 - C46;

A26-B1-C47;

A26 - B1 - C48;

A26-B1-C49;

A26-B1-C50;

A26-BI-C51;

A26-B1-C52;

A26-B1-C53;

A26 - B1 - C54;

A26 - B1 - C55;

A26-B1-C55;

A26-B1-C57;

A26-B1-C58;

A26 - B1 - C59;

A26 - B1 - C60;

A26 - B1 - C61;

A26-B1-C62;

A26-B1-C63;

A26 - B1 - C64;

A26 - B1 - C65;

A26-B1-C66;

A26 - B1 - C67;

A26-B1-C68;

A27-B1-C1;

A27-B1-C2;

A27-B1-C3;

A27-B1-C4;

A27-B1-C8;

A27-B1-C6;

A27-B1-C8;

A27-B1-C7;

A27-B1-C9;

A27-B1-C10;

A27-B1-C12;

A27-B1-C12;

A27-B1-C13;

A27-B1-C14;

A27-B1-C1S;

A27 - B1 - C16;

A27 - B1 - C17;

A27-B1-C18;

A27-B1-C19;

A27-B1-C20;

A27-B1-C2I;

A27-BI-C22;

A27-B1-C23;

A27-B1-C24;

A27 - B1 - C25;

A27-B1-C26;

A27 - B1 - C27;

A27-B1-C28;

A27-B1-C29;

A27-B1-C30;

A27-B1-C30;

A27 - B1 - C32;

A27-BI-C33;

A27-B1-C34;

A27 - B1 - C35;

A27-B1-C36;

A27 - B1 - C37;

A27-B1-C38;

A27-B1-C39;

A27-B1-C40;

A27-B1-C41;

A27-BI-C42;

A27 - B1 - C43;

A27-B1-C44;

A27-B1-C45;

A27 - B1 - C46;

A27 - B1 - C47;

-102; and

A27-B1-C48;

A27-B1-C49;

A27-B1-C50;

A27-B1-C51;

A27-B1-C52;

A27-B1-C53;

A27-B1-C54;

A27-B1-C55;

A27-B1-C55;

A27-B1-C57;

A27 - B1 - C58;

A27-B1-C59;

A27-B1-C60;

A27 - B1 - C61;

A27-B1-C62;

A27-B1-C63;

A27 - B1 - C64;

A27-B1-C65;

A27-B1-C66;

A27-B1-C67;

A27-B1- C68;

A28-B1-C1;

A28-B1-C2;

A28-B1-C3;

A28-B1-C4;

A28-B1-C8;

A28-BI-C6;

A28-B1-C8;

A28-B1-C7;

A28-B1-C9;

A28-B1-C10;

A28-B1-C12;

A28-B1-C12;

A28 - B1 - C13;

A28-B1-C14;

A28 - B1 - C15;

A28 - B1 - C16;

A28 - B1 - C17;

A28 - B1 - C18;

A28 - B1 - C19;

A28-B1-C20;

A28-B1-C21;

A28-B1-C22;

A28-B1-C23;

A28 - B1 - C24;

A28 - B1 - C25;

A28-B1-C26;

A28 - B1 - C27;

A28-B1-C28;

A28-B1-C29;

A28-B1-C30;

A28-B1-C30;

A28 - B1 - C32;

A28 - B1 - C33;

A28 - B1 - C34;

A28 - B1 - C35;

A28-B1-C36;

A28 - B1 - C37;

A28-B1-C38;

A28-B1-C39;

A28-B1-C40;

A28-B1-C41;

A28 - B1 - C42;

A28 - B1 - C43;

A28-B1-C44;

A28 - B1 - C45;

A28 - B1 - C46;

A28 - B1 - C47;

A28 - B1 - C48;

A28 - B1 - C49;

A28-B1-C50;

A28-B1-C51;

A28-B1-C52;

A28-B1-C53;

A28 - B1 - C54;

A28-B1-C55;

A28 - B1 - C56;

A28 - B1 - C57;

A28 - B1 - C58;

A28-B1-C59;

A28-B1-C60;

A28 - B1 - C61;

A28 - B1 - C62;

A28-B1-C63;

A28 - B1 - C64;

A28 - B1 - C65;

A28-B1-C66;

A28 - B1 - C67;

A28 - B1 - C68;

A29-B1-C1;

A29-B1-C2;

A29-B1-C3;

A29-B1-C4;

A29-B1-C5;

A29-B1-C6;

A29-B1-C7;

A29-B1-C8;

A29-B1-C9;

A29-B1-C10;

A29-B1-C11;

A29-B1-C12;

A29-B1-C13;

A29-B1-C14;

A29-B1-C15;

A29-B1-C16;

A29-B1-C17;

A29-B1-C18;

A29-B1-C19;

A29-B1-C20;

A29-B1-C21;

A29-B1-C22;

A29-B1-C23;

A29-B1-C24;

A29-B1-C25;

A29-B1-C26;

A29-B1-C27;

A29-B1-C28;

A29-B1-C29;

A29-B1-C30;

A29-B1-C31;

A29-B1-C32;

A29-B1-C33;

A29-B1-C34;

A29-B1-C35;

A29-B1-C36;

A29-B1-C37;

A29-B1-C38;

A29-B1-C39;

A29-B1-C40;

A29-B1-C41;

A29-B1-C42;

A29-B1-C43;

A29-B1-C44;

A29-B1-C45;

A29-B1-C46;

A29-B1-C47;

A29-B1-C48;

A29-B1-C49;

A29-B1-C50;

A29-B1-C51;

A29-B1-C52;

A29-B1-C53;

A29-B1-C54;

A29-B1-C55;

A29-B1-C56;

A29-B1-C57;

A29-B1-C58;

A29-B1-C59;

A29-B1-C60;

A29-B1-C61;

A29-B1-C62;

A29-B1-C63;

A29-B1-C64;

A29-B1-C65;

A29-B1-C66;

A29-B1-C67;

A29-B1-C68;

A30-B1-C1;

A30-B1-C2;

A3O-B1-C3;

A30-B1-C4;

A30-B1-C8;

A30-B1-C6;

A30-B1-C8;

A30-B1-C7;

-103 ♦ · • t • t t t t t

A30-B1-C9;

A30-B1-C10;

A30-B1-C12;

A30-B1-C11;

A30-B1-C12;

A30-B1-C14;

A30-B1-C14;

A30-B1-C17;

A30-B1-C16;

A30-B1-C18;

A30-B1-C19;

A30-B1-C20;

A30-B1-C21;

A30-B1-C22;

A30-B1-C23;

A30-B1-C24;

A30-B1-C25;

A30-B1-C26;

A30-B1-C28;

A30-B1-C28;

A30-B1-C29;

A30-B1-C30;

A30-B1-C30;

A30-B1-C33;

A30-B1-C33;

A30-B1-C33;

A30-B1-C35;

»»

A30-B1-C36;

A30-B1-C36;

A30-B1-C38;

A30-BI-C39;

A30-B1-C40;

A30-B1-C41;

A30-B1-C42;

A30-B1-C44;

A30-B1-C44;

A30-B1-C45;

A30-B1-C46;

A30-B1-C47;

A30-B1-C48;

A30-B1-C50;

A30-B1-C50;

A30-B1-C51;

A30-B1-C52;

A30-B1-C53;

A30-B1-C54;

A30-B1-C55;

A30-B1-C55;

A30-B1-C57;

A30-B1-C58;

A30-B1-C59;

A30-B1-C60;

A30-B1-C60;

A30-B1-C62;

A30-B1-C62;

A30-B1-C64;

A30-B1-C65;

A30-B1-C66;

A30-B1-C67;

A30-B1- C68;

A31-B1-C1;

A31-B1-C2;

A31-B1-C3;

A31-B1-C4;

A31-B1-C8;

A31-B1-C6;

A31-B1-C8;

A31-B1-C7;

A31-B1-C9;

A31-B1-C10;

A31-B1-C12;

A31-B1-C12;

A31-B1-C13;

A31-B1-C14;

A31 - B1 - C15;

A31 - B1 - C16;

A31-B1-C17;

A31-B1-C18;

A31-B1-C19;

A31-B1-C20;

A31-B1-C21;

A31-B1-C22;

A31-B1-C23;

A31-B1-C24;

A31-B1-C25;

A31-B1-C26;

A31 - B1 - C27;

A31-B1-C28;

A31-B1-C29;

A31-B1-C30;

A31-B1-C31;

A31-B1-C32;

A31-B1-C33;

A31-B1-C34;

A31 - B1 - C35;

A3I-B1-C36;

A31-B1-C37;

A31-B1-C38;

A31-B1-C39;

A31-B1-C40;

A31-B1-C41;

A31-B1-C42;

A31 - B1 - C43;

A31-B1-C44;

A31-B1-C45;

A31-B1-C46;

A31 - B1 - C47;

A31-B1-C48;

A31-B1-C49;

A31-B1-C50;

A31-B1-C51;

A31-B1-C52;

A31-B1-C53;

A31-B1-C54;

A31-B1-C55;

A31-B1-C55;

A31-B1-C57;

A31-B1-C58;

A31-B1-C59;

A31-B1-C60;

A31 - B1 - C61;

A31-B1-C62;

A31-B1-C63;

A31-B1-C64;

A31-B1-C65;

A31-B1-C66;

A31-B1-C67;

A31-B1-C68;

A32-B1-C1;

A32-B1-C2;

A32-BI-C3;

A32-B1-C4;

A32-B1-C8;

A32-B1-C6;

A32-B1-C8;

A32-B1-C7;

A32-B1-C9;

A32-B1-C10;

A32-B1-C12;

A32-B1-C11;

A32-B1-C12;

A32-B1-C14;

A32-B1-C14;

A32-B1-C17;

A32-B1-C16;

A32-B1-C18;

A32-B1-C19;

A32-B1-C20;

A32-B1-C21;

A32-B1-C22;

A32-B1-C22;

A32-B1-C24;

A32-B1-C25;

A32-B1-C25;

A32-B1-C28;

A32-B1-C28;

A32-B1-C29;

A32-B1-C30;

A32-B1-C30;

A32-B1-C32;

A32-B1-C33;

A32-B1-C33;

A32-B1-C35;

A32-B1-C36;

A32-B1-C36;

9 i

-103 «» • »·

9

9 9 ♦

A32-B1-C38;

A32-B1-C39;

A32-B1-C40;

A32-B1-C41;

A32-B1-C41;

A32-B1-C44;

A32-B1-C44;

A32-B1-C45;

A32-B1-C46;

A32-B1-C47;

A32-B1-C48;

A32-B1-C50;

A32-B1-C50;

A32-B1-C51;

A32-B1-C52;

A32-B1-C53;

A32-B1-C54

A32-B1-C55

A32-B1-C55;

A32-B1-C57;

A32-B1-C58;

A32-B1-C59;

A32-B1-C60;

A32-B1-C60;

A32-B1-C62;

A32-B1-C63;

A32-B1-C64;

A32-B1-C65;

A32-B1-C66;

A32-B1-C67;

A32-B1- C68;

A33-B1-C1;

A33-B1-C2;

A33-B1-C3;

A33-B1-C4;

A33-B1-C8;

A33-B1-C6;

A33-B1-C8;

A33-B1-C7;

A33-B1-C8;

A33-B1-C10;

A33-B1-C12;

A33-B1-C11;

A33-B1-C12;

A33-B1-C14;

A33-B1-C14;

A33-B1-C17;

A33-B1-C16;

A33-B1-C18;

A33-B1-C19;

A33-B1-C20;

A33-B1-C21;

A33-B1-C22;

A33-B1-C23;

A33-B1-C24;

A33-B1-C25;

A33-B1-C26;

A33-B1-C28;

A33-B1-C28;

A33-B1-C29;

A33-B1-C30;

A33-B1-C30;

A33-B1-C33;

A33-B1-C33;

A33-B1-C33;

A33-B1-C35;

A33-B1-C36;

A33-B1-C37;

A33-B1-C38;

A33-B1-C39;

A33-B1-C40;

A33-B1-C41;

A33-B1-C42;

A33-B1-C44;

A33-B1-C44;

A33-B1-C45;

A33-B1-C46;

A33 - B1 - C47;

A33-B1-C4S;

A33-B1-C50;

A33-B1-C50;

A33-B1-C51;

A33-B1-C52;

A33-B1-C53;

A33-B1-C54;

A33-B1-C55;

A33-B1-C55;

A33-B1-C57;

A33-B1-C58;

A33-B1-C59;

A33-B1-C60;

A33-B1-C60;

A33-B1-C62;

A33-B1-C63;

A33 - B1 - C64;

A33-B1-C65;

A33-B1-C66;

A33-B1-C67;

A33-B1- C68;

A34-B1-C1;

A34-B1-C2;

A34-B1-C3;

A34-B1-C4;

A34-B1-C8;

A34-B1-C6;

A34-B1-C8;

A34-B1-C7;

A34-B1-C9;

A34-B1-C10;

A34-B1-C12;

A34-B1-C12;

A34-B1-C12;

A34-B1-C14;

A34-B1-C14;

A34-B1-C16;

A34-B1-C18;

A34-B1-C18;

A34-B1-C19;

A34-B1-C20;

A34-B1-C21;

A34-B1-C22;

A34-B1-C23;

A34-B1-C24;

A34-B1-C25;

A34-B1-C26;

A34-B1-C28;

A34-B1-C28;

A34-B1-C29;

A34-B1-C30;

A34-B1-C30;

A34-B1-C33;

A34-B1-C33;

A34-B1-C34

A34-B1-C35;

A34-B1-C36;

A34-B1-C37;

A34-B1-C38;

A34-B1-C39;

A34-B1-C40;

A34-B1-C41;

A34-B1-C42;

A34-B1-C44;

A34-B1-C44;

A34-B1-C45;

A34-B1-C46;

A34-B1- C47;

A34-B1-C48;

A34-B1-C50;

A34-B1-C50;

A34-B1-C51;

A34-B1-C52;

A34-B1-C53;

A34-B1-C54;

A34-B1-C55;

A34-B1-C55;

A34-B1-C57;

A34-B1-C58;

A34-B1-C59;

A34-B1-C60;

A34-B1-C60;

A34-B1-C62;

A34-B1-C63;

A34-B1-C64;

A34-BI-C65;

A34-B1-C66;

- 105Φ »

φφφ · &

φφφ φφ φφφ

A34-B1-C67;

A34-B1-C68;

A35-B1-C1;

A35-B1-C2;

A35-B1-C3;

A35-B1-C4;

A35-B1-C8;

A35-B1-C6;

A35-B1-C8;

A35-B1-C8;

A3S-B1-C8;

A35-B1-C10;

A35-B1-C12;

A35-B1-C12;

A35-B1-C13;

A35-B1-C14;

A35-B1-C15;

A35-B1-C16;

A35-B1-C17;

A35-B1-C18;

A35-B1-C19;

A35-B1-C20;

A35-B1-C21;

A35-B1-C22;

A35-B1-C23;

A35-B1-C24;

A35-B1-C25;

ι

A35-B1-C26;

A35-B1- C27;

A35-B1-C28;

A35-B1-C29;

A35-B1-C30;

A35-B1-C30;

A35-B1-C32;

A35-B1-C33;

A35-B1-C34;

A35-B1-C35;

A35-B1-C36;

A35-B1-C37;

A35-B1-C38;

A35-B1-C39;

A35-B1-C40;

A35-B1-C41;

A35-B1-C42;

A35-B1-C43

A35-B1-C44;

A35-B1-C45;

A35-B1-C46;

A35-B1- C47;

A35-B1-C48;

A35-B1-C50;

A35-B1-C50;

A35-B1-C51;

A35-B1-C52;

A35-B1-C53;

A35-B1-C54;

A35-B1-C55;

A35-B1-C55;

A35-B1-C57;

A35-B1-C58;

A35-B1-C59;

A35-B1-C60;

A35-B1-C61;

A35-B1-C62;

A35-B1-C63;

A35-B1-C64;

A35-B1-C65;

A3S-B1-C65;

A35-B1-C67;

A35-B1-C68;

A36-B1-C1;

A36-B1-C2;

A36-B1-C3;

A36-B1-C4;

A36-B1-C8;

A36-B1-C6;

A36-B1-C8;

A36-B1-C7;

A36-B1-C9;

A36-B1-C10;

A36-B1-C12;

A36-B1-C12;

A36-B1-C12;

A36-B1-C14;

A36-B1-C14;

A36-B1-C16;

A36-B1-C17;

A36-B1-C18;

A36-B1-C19;

A36-B1-C20;

A36-B1-C21;

A36-B1-C22;

A36-B1-C23;

A36-B1-C24;

A36-B1-C25;

A36-B1-C26;

A36-B1- C27;

A36-B1-C28;

A36-B1-C29;

A36-B1-C30;

A36-B1-C30;

A36-B1-C33;

A36-B1-C33;

A36-B1-C34;

A36-B1-C35;

A36-B1-C36;

A36-B1-C37;

A36-B1-C38;

A36-B1-C39;

A36-B1-C40;

A36-B1-C41;

A36-B1-C42;

A36-B1-C44;

A36-B1-C44;

A36-B1-C45;

A36-B1-C46;

A36-B1- C47;

A36-B1-C48;

A36-B1-C50;

A36-B1-C50;

A36-B1-C51;

A36-B1-C52;

A36-B1-C53;

A36-B1-C54;

A36-B1-C55;

A36-B1-C55;

A36-B1-C57;

A36-B1-C58;

A36-B1-C59;

A36-B1-C60;

A36-B1- C61;

A36-B1-C62;

A36-B1-C63;

A36-B1-C64;

A36-B1-C65;

A36-B1-C66;

A36-B1-C67;

A36-B1- C68;

A37-B1-C1;

A37-B1-C2;

A37-B1-C3;

A37-B1-C4;

A37-B1-C8;

A37-B1-C6;

A37-B1-C8;

A37-B1-C7;

A37-B1-C9;

A37-B1-C10;

A37-B1-C12;

A37-B1-C12;

A37-B1-C13;

A37-B1-C14;

A37-B1-C15;

A37-B1-C16;

A37-B1-C17;

A37-B1-C18;

A37-B1-C19;

A37-B1-C20;

A37-B1-C21;

A37-B1-C22;

A37-B1-C23;

A37-B1-C24;

A37-B1-C25;

A37-B1-C26;

A37-B1-C27;

«·« ·· ·

- 106 • t · ···

A37-B1-C28;

A37-B1-C29;

A37-B1-C30;

A37-B1-C30;

A37-B1-C32;

A37-B1-C33;

A37-B1-C34;

A37-B1-C35;

A37-B1-C36;

A37-B1-C37;

A37-B1-C38;

A37-B1-C39;

A37-B1-C40;

A37-B1-C41;

A37-B1-C42;

A37-B1-C43;

A37-B1-C44;

A37-B1-C45;

A37-B1-C46;

A37-B1-C47;

A37-B1-C48;

A37-B1-C49;

A37-B1-C50;

A37-B1-C51;

A37-B1-C52;

A37-B1-C53;

A37-B1-P54

A37-B1-C55;

A37-B1-C55;

A37-B1-C57;

A37-B1-C58;

A37-B1-C59;

A37-B1-C60;

A37-B1-C61;

A37-B1-C62;

A37-B1-C63;

A37-B1-C64;

A37-B1-C65;

A37-B1-C66;

A37-B1-C67;

A37-B1-C68;

A38-B1-C1;

A38-B1-C2;

A38-B1-C3;

A38-B1-C4;

A38-B1- C5;

A38-B1-C6;

A38-B1-C8;

A38-B1-C7;

A38-B1-C9;

A38-B1-C10;

A38-B1-C12;

A38-B1-C12;

A38-B1-C12;

A38-B1-C14;

A38-B1-C14;

A38 - B1 - C16;

A38-B1-C17;

A38-B1-C18;

A38-B1-C19;

A38-B1-C20;

A38-B1-C21;

A38-B1-C22;

A38-B1-C23;

A38-B1-C24;

A38-B1-C25;

A38-BI-C26;

A38-B1- C27;

A38-B1-C28;

A38-B1-C29;

A38-B1-C30;

A38-B1-C30;

A38-B1-C33;

A38-BI-C33;

A38-B1-C34;

A38-B1-C35;

A38-B1-C36;

A38-B1-C37;

A38-B1-C38;

A38-B1-C39;

A38-B1-C40;

A38-B1-C41;

A38-B1-C42;

A38-B1-C43;

A38-B1-C44;

A38-B1-C45;

A38-B1- C46;

A38-B1- C47;

A38-B1- C48;

A38-BI-C49;

A38-B1-C50;

A38-B1-C51;

A38-B1-C52;

A38-B1-C53;

A38-B1-C54;

A38-B1-C55;

A38-B1-C55;

A38-B1-C57;

A38-B1- C58;

A38-B1-C59;

A38-B1-C60;

A38-B1-C61;

A38-B1-C62;

A38-B1-C63;

A38-B1- C64;

A38-B1-C65;

A38-B1-C66;

A38-B1-C67;

A38-B1- C68;

A1-B2-C1;

A1-B2-C2;

A1-B2-C3;

A1-B2-C4;

A1-B2-C5;

A1-B2-C6;

A1-B2-C7;

A1-B2-C8;

A1-B2-C9;

A1-B2-C10;

A1-B2-C11;

A1-B2-C12;

A1-B2-C13;

A1-B2-C14;

A1-B2-C15;

A1-B2-C16;

A1-B2-C17;

A1-B2-C18;

A1-B2-C19;

A1-B2-C20;

A1-B2-C21;

A1-B2-C22;

A1-B2-C23;

A1-B2-C24;

A1-B2-C25;

A1-B2-C26;

A1-B2-C27;

A1-B2-C28;

A1-B2-C29;

A1-B2-C30;

A1-B2-C31;

A1-B2-C32;

A1-B2-C33;

A1-B2-C34;

A1-B2-C35;

A1-B2-C36;

A1-B2-C37;

A1-B2-C38;

A1-B2-C39;

A1-B2-C40;

A1-B2-C41;

A1-B2-C42;

A1-B2-C43;

A1-B2-C44;

A1-B2-C45;

A1-B2-C46;

A1-B2-C47;

A1-B2-C48;

A1-B2-C49;

A1-B2-C50;

A1-B2-C51;

A1-B2-C52;

A1-B2-C53;

A1-B2-C54;

A1-B2-C55;

A1-B2-C56;

- 107-

·· ♦ ··

A1-B2-C57;

A1-B2-C58;

A1-B2-C59;

A1-B2-C60;

A1-B2-C61;

A1-B2-C62;

A1-B2-C63;

A1-B2-C64;

A1-B2-C65;

A1-B2-C66;

A1-B2-C67;

A1-B2-C68;

A2-B2-C1;

A2-B2-C2;

A2-B2-C3;

A2-B2-C4;

A2-B2-C5;

A2-B2-C6;

A2-B2-C7;

A2-B2-C8;

A2-B2-C9;

A2-B2-C10;

A2-B2-C11;

A2-B2-C12;

A2-B2-C13;

A2-B2-C14;

A2-B2-C15;

(

A2-B2-C16;

A2-B2-C17;

A2-B2-C18;

A2-B2-C19;

A2-B2-C20;

A2-B2-C21;

A2-B2-C22;

A2-B2-C23;

A2-B2-C24;

A2-B2-C25;

A2-B2-C26;

A2-B2-C27;

A2-B2-C28;

A2-B2-C29;

A2-B2-C30;

A2-B2-C31;

A2-B2-C32;

A2-B2-C33;

A2-B2-C34;

A2-B2-C35;

A2-B2-C36;

A2-B2-C37;

A2-B2-C38;

A2-B2-C39:

A2-B2-C40;

A2-B2-C41;

A2-B2-C42;

A2-B2-C43;

A2-B2-C44;

A2-B2-C45;

A2-B2-C46;

A2-B2-C47;

A2-B2-C48;

A2-B2-C49;

A2-B2-C50;

A2-B2-C51;

A2-B2-C52;

A2-B2-CS3;

A2-B2-C54;

A2-B2-C55;

A2-B2-C56;

A2-B2-C57;

A2-B2-C58;

A2-B2-C59;

A2-B2-C60;

A2-B2-C61;

A2-B2-C62;

A2-B2-C63;

A2-B2-C64;

A2-B2-C65;

A2-B2-C66;

A2-B2-C67;

A2-B2-C68;

A3-B2-C1;

A3-B2-C2;

A3-B2-C3;

A3-B2-C4;

A3-B2-C5;

A3-B2-C6;

A3-B2-C7;

A3-B2-C8;

A3-B2-C9;

A3-B2-C10;

A3-B2-C11;

A3-B2-C12;

A3-B2-C13;

A3-B2-C14;

A3-B2-C15;

A3-B2-C16;

A3-B2-C17;

A3-B2-C18;

A3-B2-C19;

A3-B2-C20;

A3-B2-C21;

A3-B2-C22;

A3-B2-C23;

A3-B2-C24;

A3-B2-C25;

A3-B2-C26;

A3-B2-C27;

A3-B2-C28;

A3-B2-C29;

A3-B2-C30;

A3-B2-C31;

A3-B2-C32;

A3-B2-C33;

A3-B2-C34;

A3-B2-C35;

A3-B2-C36;

A3-B2-C37;

A3-B2-C38;

A3-B2-C39;

A3-B2-C40;

A3-B2-C41;

A3-B2-C42;

A3-B2-C43;

A3-B2-C44;

A3-B2-C45;

A3-B2-C46;

A3-B2-C47;

A3-B2-C48;

A3-B2-C49;

A3-B2-CS0;

A3-B2-C51;

A3-B2-C52;

A3-B2-C53;

A3-B2-CS4;

A3-B2-C55;

A3-B2-C56;

A3-B2-C57;

A3-B2-C58;

A3-B2-C59;

A3-B2-C60;

A3-B2-C61;

A3-B2-C62;

A3-B2-C63;

A3-B2-C64;

A3-B2-C65;

A3-B2-C66;

A3-B2-C67;

A3-B2-C68;

A4-B2-C1;

A4-B2-C2;

A4-B2-C3;

A4-B2-C4;

A4-B2-C5;

A4-B2-C6;

A4-B2-C7;

A4-B2-C8;

A4-B2-C9;

A4-B2-C10;

A4-B2-C11;

A4-B2-C12;

A4-B2-C13;

A4-B2-C14;

A4-B2-C15;

A4-B2-C16;

A4-B2-C17;

- 108-

A4-B2-C18; A4-B2-CS2; A5-B2-C16; A5-B2-C49; A6-B2-C14; A4-B2-C19; A4-B2-C52; A5-B2-C17; A5-B2-C50; A6-B2-C15; A4-B2-C20; A4-B2-C53; A5-B2-C18; A5-B2-C51; A6-B2-C16; A4-B2-C21; A4-B2-C54; A5-B2-C19; A5-B2-C52; A6-B2-Cl7; A4-B2-C22; A4-B2-C55; A5-B2-C20; A5-B2-C53; A6-B2-C18; A4-B2-C23; A4-B2-C55; A5-B2-C21; A5-B2-C54; A6-B2-C19; A4-B2-C24; A4-B2-C57; A5-B2-C22; A5-B2-C55; A6-B2-C20; A4-B2-C25; A4-B2-C58; A5-B2-C23; A5-B2-C56; A6-B2-C21; A4-B2-C26; A4-B2-C59; A5-B2-C24; A5-B2-C57; A6-B2-C22; A4-B2-C27; A4-B2-C60; A5-B2-C25; A5-B2-C58; A6-B2-C23; A4-B2-C28; A4-B2-C61; A5-B2-C26; A5-B2-C59; A6-B2-C24; A4-B2-C29; A4-B2-C62; A5-B2-C27; A5-B2-C60; A6-B2-C25; A4-B2-C30; A4-B2-C63; A5-B2-C28; A5-B2-C61; A6-B2-C26; A4-B2-C31; A4-B2-C64; A5-B2-C29; A5-B2-C62; A6-B2-C27; A4-B2-C32; A4-B2-C65; A5-B2-C30; A5-B2-C63; A6-B2-C28; A4-B2-C33; A4-B2-C66; A5-B2-C31; A5-B2-C64; A6-B2-C29; A4-B2-C34; A4-B2-C67; A5-B2-C32; A5-B2-C65; A6-B2-C30; A4-B2-C35; A4-B2-C68; A5-B2-C33; A5-B2-C66; A6-B2-C31; A4-B2-C36; A5-B2-C1; A5-B2-C34; A5-B2-C67; A6-B2-C32; A4-B2-C37; A5-B2-C2; A5-B2-C35; A5-B2-C68; A6-B2-C33; A4-B2-C38; A5-B2-C3; A5-B2-C36; A6-B2-C1; A6-B2-C34; A4-B2-C39; A5-B2-C4; A5-B2-C37; A6-B2-C2; A6-B2-C35; A4-B2-C40; A5-B2-C5; A5-B2-C38; A6-B2-C3; A6-B2-C36; A4-B2-C41; A5-B2-C6; A5-B2-C39; A6-B2-C4; A6-B2-C37; A4-B2-C42; A5-B2-C7; A5-B2-C40; A6-B2-C5; A6-B2-C38; A4-B2-C43; A5-B2-C8; A5-B2-C41; A6-B2-C6; A6-B2-C39; A4-B2-C44; AND A5-B2-C9; A5-B2-C42; A6-B2-C7; A6-B2-C40; A4-B2-C45; A5-B2-C10; A5-B2-C43; A6-B2-C8; A6-B2-C41; A4-B2-C46; A5-B2-C11; A5-B2-C44; A6-B2-C9; A6-B2-C42; A4-B2-C47; A5-B2-C12; A5-B2-C45; A6-B2-C10; A6-B2-C43; A4-B2-C48; A5-B2-C13; A5-B2-C46; A6-B2-C11; A6-B2-C44; A4-B2-C49; A5-B2-C14; A5-B2-C47; A6-B2-C12; A6-B2-C45; A4-B2-C50; A5-B2-C15; A5-B2-C48; A6-B2-C13; A6-B2-C46;

-109 * ·· · »· •» »» · «-10 ·· ·· φφ ΦΦΦ φφ ΦΦΦ

A6-B2-C47; A7-B2-C12; A7-B2-C45; A8-B2-C10; A8-B2-C43; A6-B2-C48; A7-B2-C13; A7-B2-C46; A8-B2-C11; A8-B2-C44; A6-B2-C49; A7-B2-C14; A7-B2-C47; A8-B2-C12; A8-B2-C45; A6-B2-C50; A7-B2-C15; A7-B2-C48; A8-B2-C13; A8-B2-C46; A6-B2-C51; A7-B2-C16; A7-B2-C49; A8-B2-C14; A8-B2-C47; A6-B2-C52; A7-B2-C17; A7-B2-C50; A8-B2-C15; A8-B2-C48; A6-B2-C53; A7-B2-C18; A7-B2-C51; A8-B2-C16; A8-B2-C49; A6-B2-C54; A7-B2-C19; A7-B2-CS2; A8-B2-C17; A8-B2-C50; A6-B2-C55; A7-B2-C20; A7-B2-C53; A8-B2-C18; A8-B2-C51; A6-B2-C56; A7-B2-C21; A7-B2-C54; A8-B2-C19; A8-B2-C52; A6-B2-C57; A7-B2-C22; A7-B2-C55; A8-B2-C20; A8-B2-CS3; A6-B2-C58; A7-B2-C23; A7-B2-C56; A8-B2-C21; A8-B2-C54; A6-B2-C59; A7-B2-C24; A7-B2-C57; A8-B2-C22; A8-B2-C55; A6-B2-C60; A7-B2-C25; A7-B2-C58; A8-B2-C23; A8-B2-C56; A6-B2-C61; A7-B2-C26; A7-B2-C59; A8-B2-C24; A8-B2-C57; A6-B2-C62; A7-B2-C27; A7-B2-C60; A8-B2-C25; A8-B2-C58; A6-B2-C63; A7-B2-C28; A7-B2-C61; A8-B2-C26; A8-B2-C59; A6-B2-C64; A7-B2-C29; A7-B2-C62; A8-B2-C27; A8-B2-C60; A6-B2-C65; A7-B2-C30; A7-B2-C63; A8-B2-C28; A8-B2-C61; A6-B2-C66; A7-B2-C31; A7-B2-C64; A8-B2-C29; A8-B2-C62; A6-B2-C67; A7-B2-C32; A7-B2-C65; A8-B2-C30; A8-B2-C63; A6-B2-C68; A7-B2-C33; A7-B2-C66; A8-B2-C31; A8-B2-C64; A7-B2-C1; A7-B2-C34; A7-B2-C67; A8-B2-C32; A8-B2-C65; A7-B2-C2; A7-B2-C35; A7-B2-C68; A8-B2-C33; A8-B2-C66; A7-B2-C3; A7-B2-C36; A8-B2-C1; A8-B2-C34; A8-B2-C67; A7-B2-C4; A7-B2-C37; A8-B2-C2; A8-B2-C35; A8-B2-C68; A7-B2-C5; A7-B2-C38; A8-B2-C3; A8-B2-C36; A9-B2-C1; A7-B2-C6; A7-B2-C39; A8-B2-C4; A8-B2-C37; A9-B2-C2; A7-B2-C7; A7-B2-C40; A8-B2-C5; A8-B2-C38; A9-B2-C3; A7-B2-C8; A7-B2-C41; A8-B2-C6; A8-B2-C39; A9-B2-C4; A7-B2-C9; A7-B2-C42; A8-B2-C7; A8-B2-C40; A9-B2-C5; A7-B2-C10; A7-B2-C43; A8-B2-C8; A8-B2-C41; A9-B2-C6; A7-B2-C11; A7-B2-C44; A8-B2-C9; A8-B2-C42; A9-B2-C7;

-110- · »• ΦΦΦ • φφ φ φ • φ φφφ φ φφφ φ « φφφφφ φφ Φ φ φ φ ·· «φ φφ • φφφ • Φφφ · • · · · ··· φφ φφφ A9-B2-C8; A9-B2-C41; A10-B2-C6; A10-B2-C39; A11-B2-C4; A9-B2-C9; A9-B2-C42; A10-B2-C7; A10-B2-C40; A11-B2-C5; A9-B2-C10; A9-B2-C43; A10-B2-C8; A10-B2-C41; A11-B2-C6; A9-B2-C11; A9-B2-C44; A10-B2-C9; A10-B2-C42; A11-B2-C7; A9-B2-C12; A9-B2-C45; A10-B2-C10; A10-B2-C43; A11-B2-C8; A9-B2-C13; A9-B2-C46; A10-B2-C11; A10-B2-C44; A11-B2-C9; A9-B2-C14; A9-B2-C47; A10-B2-C12; A10-B2-C45; A11-B2-C10; A9-B2-C15; A9-B2-C48; A10-B2-C13; A10-B2-C46; A11-B2-C11; A9-B2-C16; A9-B2-C49; A10-B2-C14; A10-B2-C47; A11-B2-C12; A9-B2-C17; A9-B2-C50; A10-B2-C15; A10-B2-C48; A11-B2-C13; A9-B2-C18; A9-B2-C51; A10-B2-C16; A10-B2-C49; A11-B2-C14; A9-B2-C19; A9-B2-CS2; A10-B2-C17; A10-B2-C50; A11-B2-C15; A9-B2-C20; A9-B2-C53; A10-B2-C18; A10-B2-C51; A11-B2-C16; A9-B2-C21; A9-B2-C54; A10-B2-C19; A10-B2-C52; A11-B2-C17; A9-B2-C22; A9-B2-C55; A10-B2-C20; A10-B2-C53; A11-B2-C18; A9-B2-C23; A9-B2-C56; A10-B2-C21; A10-B2-C54; A11-B2-C19; A9-B2-C24; A9-B2-C57; A10-B2-C22; A10-B2-C55; A11-B2-C20; A9-B2-C25; A9-B2-C58; A10-B2-C23; A10-B2-C56; A11-B2-C21; A9-B2-C26; A9-B2-C59; A10-B2-C24; A10-B2-C57; A11-B2-C22; A9-B2-C27; A9-B2-C60; A10-B2-C25; A10-B2-C58; A11-B2-C23; A9-B2-C28; A9-B2-C61; A10-B2-C26; A10-B2-C59; A11-B2-C24; A9-B2-C29; A9-B2-C62; A10-B2-C27; A10-B2-C60; A11-B2-C25; A9-B2-C30; A9-B2-C63; A10-B2-C28; A10-B2-C61; A11-B2-C26; A9-B2-C31; A9-B2-C64; A10-B2-C29; A10-B2-C62; A11-B2-C27; A9-B2-C32; A9-B2-C65; A10-B2-C30; A10-B2-C63; A11-B2-C28; A9-B2-C33; A9-B2-C66; A10-B2-C31; A10-B2-C64; A11-B2-C29; A9-B2-Q34; A9-B2-C67; A10-B2-C32; A10-B2-C65; A11-B2-C30; A9-B2-C35; A9-B2-C68; A10-B2-C33; A10-B2-C66; A11-B2-C31; A9-B2-C36; A10-B2-C1; A10-B2-C34; A10-B2-C67; A11-B2-C32; A9-B2-C37; Al0-B2-C2; A10-B2-C35; A10-B2-C68; A11-B2-C33; A9-B2-C38; A10-B2-C3; A10-B2-C36; A11-B2-C1; A11-B2-C34; A9-B2-C39; A10-B2-C4; Al0-B2-C37; A11-B2-C2; A11-B2-C35; A9-B2-C40; A10-B2-C5; A10-B2-C38; A11-B2-C3; A11-B2-C36;

- 111 · * * 111 111 111 111 111 - 111

9 9 9 9 9

9 9 9 9 999 99 9 9

A11-B2-C37;

A11-B2-C38;

A11-B2-C39;

A11-B2-C40;

A11-B2-C41;

A11-B2-C42;

A11-B2-C43;

A11-B2-C44;

A11-B2-C45;

A11-B2-C46;

A11-B2-C47;

A11-B2-C48;

A11-B2-C49;

A11-B2-C50;

A11-B2-C51;

A11-B2-C52;

A11-B2-C53;

A11-B2-C54;

A11-B2-C55;

A11-B2-C56;

A11-B2-C57;

A11-B2-C58;

A11-B2 C59;

A11-B2-C60;

A11-B2-C61;

A11-B2-C62;

A11-B2-C63;

A11-B2-C64;

A11-B2-C65;

A11-B2-C66;

A11-B2-C67;

A11-B2-C68;

A12-B2-C1;

A12-B2-C2;

A12-B2-C3;

A12-B2-C4;

A12-B2-C5;

A12-B2-C6;

A12-B2-C7;

A12-B2-C8;

A12-B2-C9;

A12-B2-C10;

A12-B2-C11;

A12-B2-C12;

A12-B2-C13;

A12-B2-C14;

A12-B2-C15;

A12-B2-C16;

A12-B2-C17;

A12-B2-C18;

A12-B2-C19;

A12-B2-C20;

A12-B2-C21;

A12-B2-C22;

A12-B2-C23;

A12-B2-C24;

A12-B2-C25;

A12-B2-C26;

A12-B2-C27;

A12-B2-C28;

A12-B2-C29;

A12-B2-C30;

A12-B2-C31;

A12-B2-C32;

A12-B2-C33;

A12-B2-C34;

A12-B2-C35;

A12-B2-C36;

A12-B2-C37;

A12-B2-C38;

A12-B2-C39;

A12-B2-C40;

A12-B2-C41;

Al2-B2-C42;

A12-B2-C43;

Al2-B2-C44;

A12-B2-C45;

A12-B2-C46;

A12-B2-C47;

A12-B2-C48;

A12-B2-C49;

A12-B2-C50;

A12-B2-C51;

A12-B2-C52;

A12-B2 * C53;

A12-B2-C54;

A12-B2-C55;

A12-B2-C56;

A12-B2-C57;

A12-B2-C58;

A12-B2-C59;

A12-B2-C60;

A12-B2-C61;

A12-B2-C62;

A12-B2-C63;

A12-B2-C64;

A12-B2-C65;

A12-B2-C66;

Al2-B2-C67;

A12-B2-C68;

A13-B2-C1;

A 3 -B 2 -C 2;

A13-B2-C3;

A13-B2-C4;

A13-B2-C5;

A13-B2-C6;

A13-B2-C7;

A13-B2-C8;

A13-B2-C9;

A13-B2-C10;

A13-B2-C11;

A13-B2-C12;

A13-B2-C13;

A13-B2-C14;

A13-B2-C15;

A13-B2-C16;

A13-B2-C17;

A13-B2-C18;

A13-B2-C19;

A13-B2-C20;

A13-B2-C21;

A13-B2-C22;

A13-B2-C23;

A13-B2-C24;

A13-B2-C25;

A13-B2-C26;

A13-B2-C27;

A13-B2-C28;

A13-B2-C29;

A13-B2-C30;

Al3-B2-C31;

A13-B2-C32;

A13-B2-C33;

A13-B2-C34;

A13-B2-C35;

A13-B2-C36;

A13-B2-C37;

A13-B2-C38;

A13-B2-C39;

A13-B2-C40;

A13-B2-C41;

A13-B2-C42;

A13-B2-C43;

A13-B2-C44;

A13-B2-C45;

A13-B2-C46;

A13-B2-C47;

A13-B2-C48;

A13-B2-C49;

A13-B2-C50;

A13-B2-C51;

A13-B2-C52;

A13-B2-C53;

A13-B2-C54;

A13-B2-C55;

A13-B2-C56;

A13-B2-C57;

A13-B2-C58;

A13-B2-C59;

A13-B2-C60;

A13-B2-C61;

A13-B2-C62;

A13-B2-C63;

A13-B2-C64;

A13-B2-C65;

-112A13-B2-C66;

A13-B2-C67;

A13-B2-C68;

A14-B2-C1;

A14-B2-C2;

A14-B2-C3;

A14-B2-C4;

A14-B2-C5;

A14-B2-C6;

A14-B2-C7;

A14-B2-C8;

A14-B2-C9;

A14-B2-C10;

A14-B2-C11;

A14-B2-C12;

A14-B2-C13;

A14-B2-C14;

A14-B2-C15;

A14-B2-C16;

A14-B2-C17;

A14-B2-C18;

A14-B2-C19;

A14-B2-C20;

A14-B2-C21;

A14-B2-C22;

A14-B2-C23;

A14-B2-C24;

and

A14-B2-C25;

A14-B2-C26;

A14-B2-C27;

A14-B2-C28;

A14-B2-C29;

A14-B2-C30;

A14-B2-C31;

A14-B2-C32;

A14-B2-C33;

A14-B2-C34;

A14-B2-C35;

A14-B2-C36;

A14-B2-C37;

A14-B2-C38;

A14-B2-C39;

A14-B2-C40;

A14-B2-C41;

A14-B2-C42;

A14-B2-C43;

A14-B2-C44;

A14-B2-C45;

A14-B2-C46;

A14-B2-C47;

A14-B2-C48;

A14-B2-C49;

A14-B2-C50;

A14-B2-C51;

A14-B2-C52;

A14-B2-C53;

A14-B2-C54;

A14-B2-C55;

A14-B2-C56;

A14-B2-C57;

A14-B2-C58;

A14-B2-C59;

A14-B2-C60;

A14-B2-C61;

A14-B2-C62;

A14-B2-C63;

A14-B2-C64;

A14-B2-C65;

A14-B2-C66;

A14-B2-C67;

A14-B2-C68;

A15-B2-C1;

A15-B2-C2;

A15-B2-C3;

A15-B2-C4;

A15-B2-C5;

A15-B2-C6;

A15-B2-C7;

A15-B2-C8;

A15-B2-C9;

A15-B2-C10;

A15-B2-C11;

A15-B2-C12;

A15-B2-C13;

A15-B2-C14;

A15-B2-C15;

A15-B2-C16;

A15-B2-C17;

A15-B2-C18;

A15-B2-C19;

A15-B2-C20;

A15-B2-C21;

A15-B2-C22;

A15-B2-C23;

A15-B2-C24;

A15-B2-C25;

A15-B2-C26;

A15-B2-C27;

A15-B2-C28;

A15-B2-C29;

A15-B2-C30;

A15-B2-C31;

A15-B2-C32;

A15-B2-C33;

A15-B2-C34;

A15-B2-C35;

A15-B2-C36;

A15-B2-C37;

A15-B2-C38;

A15-B2-C39;

A15-B2-C40;

A15-B2-C41;

A15-B2-C42;

A15-B2-C43;

A15-B2-C44;

A15-B2-C45;

A15-B2-C46;

A15-B2-C47;

A15-B2-C48;

A15-B2-C49;

A15-B2-C50;

A15-B2-C51;

Al5-B2-C52;

A15-B2-C53;

A15-B2-C54;

A15-B2-C55;

A15-B2-C56;

A15-B2-C57;

A15-B2-C58;

A15-B2-C59;

A15-B2-C60;

A15-B2-C61;

A15-B2-C62;

A15-B2-C63;

A15-B2-C64;

A15-B2-C65;

A15-B2-C66;

A15-B2-C67;

A15-B2-C68;

A16-B2-C1;

A16-B2-C2;

A16-B2-C3;

A16-B2-C4;

A16-B2-C5;

A16-B2-C6;

A16-B2-C7;

A16-B2-C8;

A16-B2-C9;

A16-B2-C10;

A16-B2-C11;

A16-B2-C12;

A16-B2-C13;

A16-B2-C14;

A16-B2-C15;

A16-B2-C16;

A16-B2-C17;

A16-B2-C18;

A16-B2-C19;

A16-B2-C20;

A16-B2-C21;

A16-B2-C22;

A16-B2-C23;

A16-B2-C24;

A16-B2-C25;

A16-B2-C26;

-113 ♦ ·· * · tftf · · tftf tf

A16-B2-C27; A16-B2-C60; A17-B2-C25; A17-B2-CS8; A18-B2-C23; A16-B2-C28; A16-B2-C61; A17-B2-C26; A17-B2-C59; A18-B2-C24; A16-B2-C29; A16-B2-C62; A17-B2-C27; A17-B2-C60; A18-B2-C25; A16-B2-C30; A16-B2-C63; Al7-B2-C28; A17-B2-C61; A18-B2-C26; A16-B2-C31; A16-B2-C64; A17-B2-C29; A17-B2-C62; A18-B2-C27; A16-B2-C32; A16-B2-C65; A17-B2-C30; A17-B2-C63; A18-B2-C28; A16-B2-C33; A16-B2-C66; A17-B2-C31; A17-B2-C64; A18-B2-C29; A16-B2-C34; A16-B2-C67; A17-B2-C32; A17-B2-C65; A18-B2-C30; Al6-B2-C35; A16-B2-C68; A17-B2-C33; A17-B2-C66; A18-B2-C31; A16-B2-C36; A17-B2-C1; A17-B2-C34; A17-B2-C67; A18-B2-C32; A16-B2-C37; A17-B2-C2; A17-B2-C35; A17-B2-C68; A18-B2-C33; A16-B2-C38; A17-B2-C3; A17-B2-C36; A18-B2-C1; A18-B2-C34; A16-B2-C39; A17-B2-C4; A17-B2-C37; A18-B2-C2; A18-B2-C35; A16-B2-C40; A17-B2-C5; A17-B2-C38; A18-B2-C3; A18-B2-C36; A16-B2-C41; A17-B2-C6; A17-B2-C39; A18-B2-C4; A18-B2-C37; A16-B2-C42; A17-B2-C7; A17-B2-C40; A18-B2-C5; A18-B2-C38; A16-B2-C43; A17-B2-C8; A17-B2-C41; A18-B2-C6; A18-B2-C39; A16-B2-C44; A17-B2-C9; A17-B2-C42; A18-B2-C7; A18-B2-C40; A16-B2-C45; A17-B2-C10; A17-B2-C43; A18-B2-C8; A18-B2-C41; A16-B2-C46; A17-B2-C11; A17-B2-C44; A18-B2-C9; A18-B2-C42; A16-B2-C47; A17-B2-C12; A17-B2-C45; A18-B2-C10; A18-B2-C43; A16-B2-C48; A17-B2-C13; A17-B2-C4O; A18-B2-C11; A18-B2-C44; A16-B2-C49; ΛΓ7-Β2-Ο4; A17-B2-C47; A18-B2-C12; A18-B2-C45; A16-B2-C50; A17-B2-C15; A17-B2-C48; A18-B2-C13; A18-B2-C46; A16-B2-C51; A17-B2-C16; A17-B2-C49; A18-B2-C14; A18-B2-C47; A16-B2-C52; A17-B2-C17; A17-B2-C50; A18-B2-C15; A18-B2-C48; A16-B2-C53; A17-B2-C18; A17-B2-C51; A18-B2-C16; A18-B2-C49; Al6-B2-C54; A17-B2-C19; A17-B2-C52; A18-B2-C17; A18-B2-C50; A16-B2-C55; A17-B2-C20; A17-B2-C53; A18-B2-C18; A18-B2-C51; A16-B2-C56; A17-B2-C21; A17-B2-C54; A18-B2-C19; A18-B2-C52; A16-B2-CS7; A17-B2-C22; A17-B2-C55; A18-B2-C20; A18-B2-C53; A16-B2-C58; A17-B2-C23; A17-B2-C56; A18-B2-C21; A18-B2-CS4; A16-B2-C59; A17-B2-C24; A17-B2-C57; A18-B2-C22; A18-B2-C55;

9

- 114-

A18-B2-C56;

A18-B2-C57;

A18-B2-C58;

A18-B2-C59;

A18-B2-C60;

A18-B2-C61;

A18-B2-C62;

A18-B2-C63;

A18-B2-C64;

A18-B2-C65;

A18-B2-C66;

A18-B2-C67;

A18-B2-C68;

A19-B2-C1;

A19-B2-C2;

A19-B2-C3;

A19-B2-C4;

A19-B2-C5;

A19-B2-C6;

A19-B2-C7;

A19-B2-C8;

A19-B2-C9;

A19-B2-C10;

A19-B2-C11;

A19-B2-C12;

A19-B2-C13;

A19-B2-C14;

A19-B2-C15;

A19-B2-C16;

A19-B2-C17;

A19-B2-C18;

A19-B2-C19;

A19-B2-C20;

A19-B2-C21;

A19-B2-C22;

A19-B2-C23;

A19-B2-C24;

A19-B2-C25;

A19-B2-C26;

A19-B2-C27;

A19-B2-C28;

A19-B2-C29;

A19-B2-C30;

A19-B2-C31;

A19-B2-C32;

A19-B2-C33;

A19-B2-C34;

A19-B2-C35;

A19-B2-C36;

A19-B2-C37;

A19-B2-C38;

A19-B2-C39;

A19-B2-C40;

A19-B2-C41;

A19-B2-C42;

A19-B2-C43;

A19-B2-C44;

A19-B2-C45;

A19-B2-C46;

A19-B2-C47;

A19-B2-C48;

A19-B2-C49;

A19-B2-C50;

A19-B2-C51;

A19-B2-C52;

A19-B2-C53;

A19-B2-C54;

A19-B2-C55;

A19-B2-C56;

A19-B2-C57;

A19-B2-C58;

A19-B2-C59;

A19-B2-C60;

A19-B2-C61;

A19-B2-C62;

A19-B2-C63;

A19-B2-C64;

A19-B2-CO5;

A19-B2-C66;

A19-B2-C67;

A19-B2-C68;

A20-B2-C1;

A20-B2-C2;

A20-B2-C3;

A20-B2-C4;

A20-B2-C5;

A20-B2-C6;

A20-B2-C7;

A20-B2-C8;

A20-B2-C9;

A20-B2-C10;

A20-B2-C11;

A20-B2-C12;

A20-B2-C13;

A20-B2-C14;

A20-B2-C15;

A20-B2-C16;

A20-B2-C17;

A20-B2-C18;

A20-B2-C19;

A20-B2-C20;

A20-B2-C21;

A20-B2-C22;

A20-B2-C23;

A20-B2-C24;

A20-B2-C25;

A20-B2-C26;

A20-B2-C27;

A20-B2-C28;

A20-B2-C29;

A20-B2-C30;

A20-B2-C31;

A20-B2-C32;

A20-B2-C33;

A20-B2-C34;

A20-B2-C35;

A20-B2-C36;

A20-B2-C37;

A20-B2-C38;

A20-B2-C39;

A20-B2-C40;

A20-B2-C41;

A20-B2-C42;

A20-B2-C43;

A20-B2-C44;

A20-B2-C45;

A20-B2-C46;

A20-B2-C47;

A20-B2-C48;

A20-B2-C49;

A20-B2-C50;

A20-B2-C51;

A20-B2-C52;

A20-B2-C53;

A20-B2-C54;

A20-B2-C55;

A20-B2-C56;

A20-B2-C57;

A20-B2-C58;

A20-B2-C59;

A20-B2-C60;

A20-B2-C61;

A20-B2-C62;

A20-B2-C63;

A20-B2-C64;

A20-B2-C65;

A20-B2-C66;

A20-B2-C67;

A20-B2-C68;

A21-B2-C1;

A21-B2-C2;

A21-B2-C3;

A21-B2-C4;

A21-B2-C5;

A21-B2-C6;

A21-B2-C7;

A21-B2-C8;

A21-B2-C9;

A21-B2-C10;

A21-B2-C11;

A21-B2-C12;

A21-B2-C13;

A21-B2-C14;

A21-B2-C15;

A21-B2-C16;

- 115-

A21-B2-C17; A21-B2-C50; A22-B2-C15; A22-B2-C48; A23-B2-C13; A21-B2-C18; A21-B2-C51; A22-B2-C16; A22-B2-C49; A23-B2-C14; A21-B2-C19; A21-B2-C52; A22-B2-C17; A22-B2-C50; A23-B2-C15; A21-B2-C20; A21-B2-C53; A22-B2-C18; A22-B2-C51; A23-B2-C16; A21-B2-C21; A21-B2-C54; A22-B2-C19; A22-B2-C52; A23-B2-Cl7; A21-B2-C22; A21-B2-C55; A22-B2-C20; A22-B2-C53; A23-B2-C18; A21-B2-C23; A21-B2-C56; A22-B2-C21; A22-B2-CS4; A23-B2-C19; A21-B2-C24; A21-B2-C57; A22-B2-C22; A22-B2-C55; A23-B2-C20; A21-B2-C25; A21-B2-C58; A22-B2-C23; A22-B2-C56; A23-B2-C21; A21-B2-C26; A21-B2-C59; A22-B2-C24; A22-B2-C57; A23-B2-C22; A21-B2-C27; A21-B2-C60; A22-B2-C25; A22-B2-C58; A23-B2-C23; A21-B2-C28; A21-B2-C61; A22-B2-C26; A22-B2-C59; A23-B2-C24; A21-B2-C29; A21-B2-C62; A22-B2-C27; A22-B2-C60; A23-B2-C2S; A21-B2-C30; A21-B2-C63; A22-B2-C28; A22-B2-C61; A23-B2-C26; A21-B2-C31; A21-B2-C64; A22-B2-C29; A22-B2-C62; A23-B2-C27; A21-B2-C32; A21-B2-C65; A22-B2-C30; A22-B2-C63; A23-B2-C28; A21-B2-C33; A21-B2-C66; A22-B2-C31; A22-B2-C64; A23-B2-C29; A21-B2-C34; A21-B2-C67; A22-B2-C32; A22-B2-C65; A23-B2-C30; A21-B2-C35; A21-B2-C68; A22-B2-C33; A22-B2-C66; A23-B2-C31; A21-B2-C36; A22-B2-C1; A22-B2-C34; A22-B2-C67; A23-B2-C32; A21-B2-C37; A22-B2-C2; A22-B2-C35; A22-B2-C68; A23-B2-C33; A21-B2-C38; A22-B2-C3; A22-B2-C36; A23-B2-C1; A23-B2-C34; A21-B2-C39; A22-B2-C4; A22-B2-C37; A23-B2-C2; A23-B2-C35; A21-B2-C40; A22-B2-C5; A22-B2-C38; A23-B2-C3; A23-B2-C36; A21-B2-C41; A22-B2-C6; A22-B2-C39; A23-B2-C4; A23-B2-C37; A21-B2-C42; A22-B2-C7; A22-B2-C40; A23-B2-C5; A23-B2-C38; A21-B2-C43; A22-B2-C8; A22-B2-C41; A23-B2-C6; A23-B2-C39; A21-B2-C44; A22-B2-C9; A22-B2-C42; A23-B2-C7; A23-B2-C40; A21-B2-C45; A22-B2-C10; A22-B2-C43; A23-B2-C8; A23-B2-C41; A21-B2-C46; A22-B2-C11; A22-B2-C44; A23-B2-C9; A23-B2-C42; A21-B2-C47; A22-B2-C12; A22-B2-C45; A23-B2-C10; A23-B2-C43; A21-B2-C48; A22-B2-C13; A22-B2-C46; A23-B2-C11; A23-B2-C44; A21-B2-C49; A22-B2-C14; A22-B2-C47; A23-B2-C12; A23-B2-C45;

-116 ··· ·················································

A23-B2-C46;

A23-B2-C47;

A23-B2-C48;

A23-B2-C49;

A23-B2-C50;

A23-B2-C51;

A23-B2-C52;

A23-B2-C53;

A23-B2-C54;

A23-B2-C55;

A23-B2-C56;

A23-B2-C57;

A23-B2-CS8;

A23-B2-C59;

A23-B2-C60;

A23-B2-C61;

A23-B2-C62;

A23-B2-C63;

A23-B2-C64;

A23-B2-C65;

A23-B2-C66;

A23-B2-C67;

A23-B2-C68;

A24-B2-C1;

A24-B2-C2;

A24-B2-C3;

A24-B2-C4;

t

A24-B2-C5;

A24-B2-C6;

A24-B2-C7;

A24-B2-C8;

A24-B2-C9;

A24-B2-C10;

A24-B2-C1I;

A24-B2-C12;

A24-B2-Cl3;

A24-B2-C14;

A24-B2-C15;

A24-B2-C16;

A24-B2-C17;

A24-B2-C18;

A24-B2-C19;

A24-B2-C20;

A24-B2-C21;

A24-B2-C22;

A24-B2-C23;

A24-B2-C24;

A24-B2-C25;

A24-B2-C26;

A24-B2-C27;

A24-B2-C28;

A24-B2-C29;

A24-B2-C30;

A24-B2-C31;

A24-B2-C32;

A24-B2-C33;

A24-B2-C34;

A24-B2-C35;

A24-B2-C36;

A24-B2-C37;

A24-B2-C38;

A24-B2-C39;

A24-B2-C40;

A24-B2-C41;

A24-B2-C42;

A24-B2-C43;

A24-B2-C44;

A24-B2-C45;

A24-B2-C46;

A24-B2-C47;

A24-B2-C48;

A24-B2-C49;

A24-B2-C50;

A24-B2-CS2;

A24-B2-C52;

A24-B2-C53;

A24-B2-C54;

A24-B2-C55;

A24-B2-C56;

A24-B2-C57;

A24-B2-C58;

A24-B2-C59;

A24-B2-C60;

A24-B2-C61;

A24-B2-C62;

A24-B2-C63;

A24-B2-C64;

A24-B2-C65;

A24-B2-C66;

A24-B2-C67;

A24-B2-C68;

A25-B2-C1;

A25-B2-C2;

A25-B2-C3;

A25-B2-C4;

A25-B2-CS;

A25-B2-C6;

A25-B2-C7;

A25-B2-C8;

A25-B2-C9;

A25-B2-C10;

A25-B2-C11;

A25-B2-C12;

A25-B2-C13;

A25-B2-C14;

A25-B2-C15;

A25-B2-C16;

A25-B2-C17;

A25-B2-C18;

A25-B2-C19;

A25-B2-C20;

A25-B2-C21;

A25-B2-C22;

A25-B2-C23;

A25-B2-C24;

A25-B2-C25;

A25-B2-C26;

A25-B2-C27;

A25-B2-C28;

A25-B2-C29;

A25-B2-C30;

A25-B2-C31;

A25-B2-C32;

A25-B2-C33;

A25-B2-C34;

A25-B2-C35;

A25-B2-C36;

A25-B2-C37;

A25-B2-C38;

A25-B2-C39;

A25-B2-C40;

A25-B2-C41;

A25-B2-C42;

A25-B2-C43;

A25-B2-C44;

A25-B2-C45;

A25-B2-C46;

A25-B2-C47;

A25-B2-C48;

A25-B2-C49;

A25-B2-C50;

A25-B2-C51;

A25-B2-C52;

A25-B2-C53;

A25-B2-C54;

A25-B2-C55;

A25-B2-C56;

A25-B2-C57;

A25-B2-C58;

A25-B2-C59;

A25-B2-C60;

A2S-B2-C61;

A25-B2-C62;

A25-B2-C63;

A25-B2-C64;

A25-B2-C65;

A25-B2-C66;

A25-B2-C67;

A25-B2-C68;

A26-B2-C1;

A26-B2-C2;

A26-B2-C3;

A26-B2-C4;

A26-B2-C5;

A26-B2-C6;

4 4 4

-1178 4 4 4 9 9 4 9

98 94 449 44 4

A26-B2-C7; A26-B2-C40; A27-B2-C5; A27-B2-C38; A28-B2-C3; A26-B2-C8; A26-B2-C41; A27-B2-C6; A27-B2-C39; A28-B2-C4; A26-B2-C9; A26-B2-C42; A27-B2-C7; A27-B2-C40; A28-B2-C5; A26-B2-C10; A26-B2-C43; A27-B2-C8; A27-B2-C41; A28-B2-C6; A26-B2-C11; A26-B2-C44; A27-B2-C9; A27-B2-C42; A28-B2-C7; A26-B2-C12; A26-B2-C45; A27-B2-C10; A27-B2-C43; A28-B2-C8; A26-B2-C13; A26-B2-C46; A27-B2-C11; A27-B2-C44; A28-B2-C9; A26-B2-C14; A26-B2-C47; A27-B2-C12; A27-B2-C45; A28-B2-C10; A26-B2-C15; A26-B2-C48; A27-B2-C13; A27-B2-C46; A28-B2-C11; A26-B2-C16; A26-B2-C49; A27-B2-C14; A27-B2-C47; A28-B2-C12; A26-B2-C17; A26-B2-C50; A27-B2-C15; A27-B2-C48; A28-B2-C13; A26-B2-C18; A26-B2-C51; A27-B2-C16; A27-B2-C49; A28-B2-C14; A26-B2-C19; A26-B2-C52; A27-B2-C17; A27-B2-C50; A28-B2-C15; A26-B2-C20; A26-B2-C53; A27-B2-C18; A27-B2-C51; A28-B2-C16; A26-B2-C21; A26-B2-C54; A27-B2-C19; A27-B2-C52; A28-B2-C17; A26-B2-C22; A26-B2-C55; A27-B2-C20; A27-B2-C53; A28-B2-C18; A26-B2-C23; A26-B2-C56; A27-B2-C21; A27-B2-C54; A28-B2-C19; A26-B2-C24; A26-B2-C57; A27-B2-C22; A27-B2-C55; A28-B2-C20; A26-B2-C25; A26-B2-C58; A27-B2-C23; A27-B2-C56; A28-B2-C21; A26-B2-C26; A26-B2-C59; A27-B2-C24; A27-B2-C57; A28-B2-C22; A26-B2-C27; A26-B2-C60; A27-B2-C25; A27-B2-C58; A28-B2-C23; A26-B2-C28; A26-B2-C61; A27-B2-C26; A27-B2-C59; A28-B2-C24; A26-B2-C29; A26-B2-C62; A27-B2-C27; A27-B2-C60; A28-B2-C25; A26-B2-C30; A26-B2-C63; A27-B2-C28; A27-B2-C61; A28-B2-C26; A26-B2-C31; A26-B2-C64; A27-B2-C29; A27-B2-C62; A28-B2-C27; A26-B2-C32; A26-B2-C65; A27-B2-C30; A27-B2-C63; A28-B2-C28; A26-B2-C33; A26-B2-C66; A27-B2-C31; A27-B2-C64; A28-B2-C29; A26-B2-C34; A26-B2-C67; A27-B2-C32; A27-B2-C65; A28-B2-C30; A26-B2-C35; A26-B2-C68; A27-B2-C33; A27-B2-C66; A28-B2-C31; A26-B2-C36; A27-B2-C1; A27-B2-C34; A27-B2-C67; A28-B2-C32; A26-B2-C37; A27-B2-C2; A27-B2-C35; A27-B2-C68; A28-B2-C33; A26-B2-C38; A27-B2-C3; A27-B2-C36; A28-B2-C1; A28-B2-C34; A26-B2-C39; A27-B2-C4; A27-B2-C37; A28-B2-C2; A28-B2-C35;

-118 • 9

A28-B2-C36;

A28-B2-C37;

A28-B2-C38;

A28-B2-C39;

A28-B2-C40;

A28-B2-C41;

A28-B2-C42;

A28-B2-C43;

A28-B2-C44;

A28-B2-C45;

A28-B2-C46;

A28-B2-C47;

A28-B2-C48;

A28-B2-C49;

A28-B2-C50;

A28-B2-C51;

A28-B2-C52;

A28-B2-C53;

A28-B2-C54;

A28-B2-C55;

A28-B2-C56;

A28-B2-C57;

A28-B2-C58;

A28-B2-C59;

A28-B2-C60;

A28-B2-C61;

A28-B2-C62;

A28-B2-C63;

A28-B2-C64;

A28-B2-C65;

A28-B2-C66;

A28-B2-C67;

A28-B2-C68;

A29-B2-C1;

A29-B2-C2;

A29-B2-C3;

A29-B2-C4;

A29-B2-C5;

A29-B2-C6;

A29-B2-C7;

A29-B2-C8;

A29-B2-C9;

A29-B2-C10;

A29-B2-C11;

A29-B2-C12;

A29-B2-C13;

A29-B2-C14;

A29-B2-C15;

A29-B2-C16;

A29-B2-C17;

A29-B2-C18;

A29-B2-C19;

A29-B2-C20;

A29-B2-C21;

A29-B2-C22;

A29-B2-C23;

A29-B2-C24;

A29-B2-C25;

A29-B2-C26;

A29-B2-C27;

A29-B2-C28;

A29-B2-C29;

A29-B2-C30;

A29-B2-C31;

A29-B2-C32;

A29-B2-C33;

A29-B2-C34;

A29-B2-C35;

A29-B2-C36;

A29-B2-C37;

A29-B2-C38;

A29-B2-C39;

A29-B2-C40;

A29-B2-C41;

A29-B2-C42;

A29-B2-C43;

A29-B2-C44;

A29-B2-C45;

A29-B2-C46;

A29-B2-C47;

A29-B2-C48;

A29-B2-C49;

A29-B2-C50;

A29-B2-C51;

A29-B2-C52;

A29-B2-C53;

A29-B2-C54;

A29-B2-C55;

A29-B2-C56;

A29-B2-C57;

A29-B2-C58;

A29-B2-C59;

A29-B2-C60;

A29-B2-C61;

A29-B2-C62;

A29-B2-C63;

A29-B2-C64;

A29-B2-C65;

A29-B2-C66;

A29-B2-C67;

A29-B2-C68;

A30-B2-C1;

A30-B2-C2;

A30-B2-C3;

A30-B2-C4;

A30-B2-C5;

A30-B2-C6;

A30-B2-C7;

A30-B2-C8;

A30-B2-C9;

A30-B2-C10;

A30-B2-C11;

A30-B2-C12;

A30-B2-C13;

A30-B2-C14;

A30-B2-C15;

A30-B2-C16;

A30-B2-C17;

A30-B2-C18;

A30-B2-C19;

A30-B2-C20;

A30-B2-C21;

A30-B2-C22;

A30-B2-C23;

A30-B2-C24;

A30-B2-C25;

A30-B2-C26;

A30-B2-C27;

A30-B2-C28;

A30-B2-C29;

A30-B2-C30;

A30-B2-C31;

A30-B2-C32;

A30-B2-C33;

A30-B2-C34;

A30-B2-C35;

A30-B2-C36;

A30-B2-C37;

A30-B2-C38;

A30-B2-C39;

A30-B2-C40;

A30-B2-C41;

A30-B2-C42;

A30-B2-C43;

A30-B2-C44;

A30-B2-C45;

A30-B2-C46;

A30-B2-C47;

A30-B2-C48;

A30-B2-C49;

A30-B2-C50;

A30-B2-C51;

A30-B2-C52;

A30-B2-C53;

A30-B2-C54;

A30-B2-C55;

A30-B2-C56;

A30-B2-C57;

A30-B2-C58;

A30-B2-C59;

A30-B2-C60;

A30-B2-C61;

A30-B2-C62;

A30-B2-C63;

A30-B2-C64;

- 119 • 4 · 4 4 4 4 4 44 4 4 4 4 4 4 4 44 4 4 4 4 4 4 4 4 4 ® 4 4 4 ··· 44 «« 4

A30-B2-C65;

A30-B2-C66;

A30-B2-C67;

A30-B2-C68;

A31-B2-C1;

A31-B2-C2;

A31-B2-C3;

A31-B2-C4;

A31-B2-C5;

A31-B2-C6;

A31-B2-C7;

A31-B2-C8;

A31-B2-C9;

A31-B2-C10;

A31-B2-C11;

A31-B2-C12;

A31-B2-C13;

A31-B2-C14;

A31-B2-C15;

A31-B2-C16;

A31-B2-C17;

A31-B2-C18;

A31-B2-C19;

A31-B2-C20;

A31-B2-C21;

A31-B2-C22;

A31-B2-Cl3;

A31-B2-C24;

A31-B2-C25;

A31-B2-C26;

A31-B2-C27;

A31-B2-C28;

A31-B2-C29;

A31-B2-C30;

A31-B2-C31;

A31-B2-C32;

A31-B2-C33;

A31-B2-C34;

A31-B2-C35;

A31-B2-C36;

A31-B2-C37;

A31-B2-C38;

A31-B2-C39;

A31-B2-C40;

A31-B2-C41;

A31-B2-C42;

A31-B2-C43;

A31-B2-C44;

A31-B2-C45;

A31-B2-C46;

A31-B2-C47;

A31-B2-C48;

A31-B2-C49;

A31-B2-C50;

A31-B2-C51;

A31-B2-C52;

A31-B2-C53;

A31-B2-C54;

A31-B2-C55;

A31-B2-C56;

A31-B2-C57;

A31-B2-C58;

A31-B2-C59;

A31-B2-C60;

A31-B2-C61;

A31-B2-C62;

A31-B2-C63;

A31-B2-C64;

A31-B2-C65;

A31-B2-C66;

A31-B2-C67;

A31-B2-C68;

A32-B2-C1;

A32-B2-C2;

A32-B2-C3;

A32-B2-C4;

A32-B2-C5;

A32-B2-C6;

A32-B2-C7;

A32-B2-C8;

A32-B2-C9;

A32-B2-C10;

A32-B2-C11;

A32-B2-C12;

A32-B2-C13;

A32-B2-C14;

A32-B2-C15;

A32-B2-C16;

A32-B2-C17;

A32-B2-C18;

A32-B2-C19;

A32-B2-C20;

A32-B2-C21;

A32-B2-C22;

A32-B2-C23;

A32-B2-C24;

A32-B2-C25;

A32-B2-C26;

A32-B2-C27;

A32-B2-C28;

A32-B2-C29;

A32-B2-C30;

A32-B2-C31;

A32-B2-C32;

A32-B2-C33;

A32-B2-C34;

A32-B2-C35;

A32-B2-C36;

A32-B2-C37;

A32-B2-C38;

A32-B2-C39;

A32-B2-C40;

A32-B2-C41;

A32-B2-C42;

A32-B2-C43;

A32-B2-C44;

A32-B2-C45;

A32-B2-C46;

A32-B2-C47;

A32-B2-C48;

A32-B2-C49;

A32-B2-C50

A32-B2-C51;

A32-B2-C52;

A32-B2-C53;

A32-B2-C54;

A32-B2-C55;

A32-B2-C56;

A32-B2-C57;

A32-B2-C58;

A32-B2-C59;

A32-B2-C60;

A32-B2-C61;

A32-B2-C62;

A32-B2-C63;

A32-B2-C64;

A32-B2-C65;

A32-B2-C66;

A32-B2-C67;

A32-B2-C68;

A33-B2-C1;

A33-B2-C2;

A33-B2-C3;

A33-B2-C4;

A33-B2-C5;

A33-B2-C6;

A33-B2-C7;

A33-B2-C8;

A33-B2-C9;

A33-B2-C10;

A33-B2-C11;

A33-B2-C12;

A33-B2-C13;

A33-B2-C14;

A33-B2-C15;

A33-B2-C16;

A33-B2-C17;

A33-B2-C18;

A33-B2-C19;

A33-B2-C20;

A33-B2-C21;

A33-B2-C22;

A33-B2-C23;

A33-B2-C24;

A33-B2-C25;

Φ ·

- 1209 9 9 9 · * 9 9 9 99 99 9 9 9 9 9 9

999 9 9 9 9 99 9 99

A33-B2-C26;

A33-B2-C27;

A33-B2-C28;

A33-B2-C29;

A33-B2-C30;

A33-B2-C31;

A33-B2-C32;

A33-B2-C33;

A33-B2-C34;

A33-B2-C35;

A33-B2-C36;

A33-B2-C37;

A33-B2-C38;

A33-B2-C39;

A33-B2-C40;

A33-B2-C41;

A33-B2-C42;

A33-B2-C43;

A33-B2-C44;

A33-B2-C45;

A33-B2-C46;

A33-B2-C47;

A33-B2-C48;

A33-B2-C49;

A33-B2-C50;

A33-B2-C51;

A33-B2-C52;

AND

A33-B2-C53;

A33-B2-C54;

A33-B2-C55;

A33-B2-C56;

A33-B2-C57;

A33-B2-C58;

A33-B2-C59;

A33-B2-C60;

A33-B2-C61;

A33-B2-C62;

A33-B2-C63;

A33-B2-C64;

A33-B2-C65;

A33-B2-C66;

A33-B2-C67;

A33-B2-C68;

A34-B2-C1;

A34-B2-C2;

A34-B2-C3;

A34-B2-C4;

A34-B2-C5;

A34-B2-C6;

A34-B2-C7;

A34-B2-C8;

A34-B2-C9;

A34-B2-C10;

A34-B2-C11;

A34-B2-C12;

A34-B2-C13;

A34-B2-C14;

A34-B2-C15;

A34-B2-C16;

A34-B2-C17;

A34-B2-C18;

A34-B2-C19;

A34-B2-C20;

A34-B2-C21;

A34-B2-C22;

A34-B2-C23;

A34-B2-C24;

A34-B2-C25;

A34-B2-C26;

A34-B2-C27;

A34-B2-C28;

A34-B2-C29;

A34-B2-C30;

A34-B2-C31;

A34-B2-C32;

A34-B2-C33;

A34-B2-C34;

A34-B2-C35;

A34-B2-C36;

A34-B2-C37;

A34-B2-C38;

A34-B2-C39;

A34-B2-C40;

A34-B2-C41;

A34-B2-C42;

A34-B2-C43;

A34-B2-C44;

A34-B2-C45;

A34-B2-C46;

A34-B2-C47;

A34-B2-C48;

A34-B2-C49;

A34-B2-C50;

A34-B2-C51;

A34-B2-C52;

A34-B2-C53;

A34-B2-C54;

A34-B2-C55;

A34-B2-C56;

A34-B2-C57;

A34-B2-C58;

A34-B2-CS9;

A34-B2-C60;

A34-B2-C61;

A34-B2-C62;

A34-B2-C63;

A34-B2-C64;

A34-B2-C65;

A34-B2-C66;

A34-B2-C67;

A34-B2-C68;

A35-B2-C1;

A35-B2-C2;

A35-B2-C3;

A35-B2-C4;

A35-B2-C5;

A35-B2-C6;

A35-B2-C7;

A35-B2-C8;

A35-B2-C9;

A35-B2-C10;

A35-B2-C11;

A35-B2-C12;

A35-B2-C13;

A35-B2-C14;

A35-B2-C15;

A35-B2-C16;

A35-B2-C17;

A35-B2-C18;

A35-B2-C19;

A35-B2-C20;

A35-B2-C21;

A35-B2-C22;

A35-B2-C23;

A35-B2-C24;

A35-B2-C25;

A35-B2-C26;

A35-B2-C27;

A35-B2-C28;

A35-B2-C29;

A35-B2-C30;

A35-B2-C31;

A35-B2-C32;

A35-B2-C33;

A35-B2-C34;

A35-B2-C35;

A35-B2-C36;

A35-B2-C37;

A35-B2-C38;

A35-B2-C39;

A35-B2-C40;

A35-B2-C41;

A35-B2-C42;

A35-B2-C43;

A35-B2-C44;

A35-B2-C45;

A35-B2-C46;

A35-B2-C47;

A35-B2-C48;

A35-B2-C49;

A35-B2-C50;

A35-B2-C51;

A35-B2-C52;

A35-B2-C53;

A35-B2-C54;

• · · · · · · · · · · · · · · ·

- 121 · · · · φ · · · φφφφφφφφφφφφφφφ

A35-B2-C55; A36-B2-C20; A36-B2-C53; A37-B2-C18; A37-B2-C51; A35-B2-C56; A36-B2-C21; A36-B2-C54; A37-B2-C19; A37-B2-C52; A35-B2-C57; A36-B2-C22; A36-B2-CS5; A37-B2-C20; A37-B2-C53; A35-B2-C58; A36-B2-C23; A36-B2-C56; A37-B2-C21; A37-B2-C54; A35-B2-C59; A36-B2-C24; A36-B2-C57; A37-B2-C22; A37-B2-C55; A35-B2-C60; A36-B2-C25; A36-B2-C58; A37-B2-C23; A37-B2-C56; A35-B2-C61; A36-B2-C26; A36-B2-C59; A37-B2-C24; A37-B2-C57; A35-B2-C62; A36-B2-C27; A36-B2-C60; A37-B2-C25; A37-B2-C58; A35-B2-C63; A36-B2-C28; A36-B2-C61; A37-B2-C26; A37-B2-C59; A35-B2-C64; A36-B2-C29; A36-B2-C62; A37-B2-C27; A37-B2-C60; A35-B2-C65; A36-B2-C30; A36-B2-C63; A37-B2-C28; A37-B2-C61; A35-B2-C66; A36-B2-C31; A36-B2-C64; A37-B2-C29; A37-B2-C62; A35-B2-C67; A36-B2-C32; A36-B2-C65; A37-B2-C30; A37-B2-C63; A35-B2-C68; A36-B2-C33; A36-B2-C66; A37-B2-C31; A37-B2-C64; A36-B2-C1; A36-B2-C34; A36-B2-C67; A37-B2-C32; A37-B2-C65; A36-B2-C2; A36-B2-C35; A36-B2-C68; A37-B2-C33; A37-B2-C66; A36-B2-C3; A36-B2-C36; A37-B2-C1; A37-B2-C34; A37-B2-C67; A36-B2-C4; A36-B2-C37; A37-B2-C2; A37-B2-C35; A37-B2-C68; A36-B2-C5; A36-B2-C38; A37-B2-C3; A37-B2-C36; A38-B2-C1; A36-B2-C6; A36-B2-C39; A37-B2-C4; A37-B2-C37; A38-B2-C2; A36-B2-C7; A36-B2-C40; A37-B2-C5; A37-B2-C38; A38-B2-C3; A36-B2-C8; A36-B2-C41; A37-B2-C6; A37-B2-C39; A38-B2-C4; A36-B2-C9; A36-B2-C42; A37-B2-C7; A37-B2-C40; A38-B2-C5; A36-B2-C10; A36-B2-C43; A37-B2-C8; A37-B2-C41; A38-B2-C6; A36-B2-C11; A36-B2-C44; A37-B2-C9; A37-B2-C42; A38-B2-C7; A36-B2-C12; A36-B2-C45; A37-B2-C10; A37-B2-C43; A38-B2-C8; A36-B2-C13; A36-B2-C46; A37-B2-C11; A37-B2-C44; A38-B2-C9; A36-B2-C14; A36-B2-C47; A37-B2-C12; A37-B2-C45; A38-B2-C10; A36-B2-C15; A36-B2-C48; A37-B2-C13; A37-B2-C46; A38-B2-C11; A36-B2-C16; A36-B2-C49; A37-B2-C14; A37-B2-C47; A38-B2-C12; A36-B2-C17; A36-B2-C50; A37-B2-C15; A37-B2-C48; A38-B2-C13; A36-B2-C18; A36-B2-C51; A37-B2-C16; A37-B2-C49; A38-B2-C14; A36-B2-C19; A36-B2-CS2; A37-B2-C17; A37-B2-C50; A38-B2-C15;

* · 4 · 4 · 4 · 4 ·

4 4 4 4 4

- 1224 * 4 · · φ «44 ·· ·

A38-B2-C16;

A38-B2-C17;

A38-B2-C18;

A38-B2-C19;

A38-B2-C20;

A38-B2-C21;

A38-B2-C22;

A38-B2-C23;

A38-B2-C24;

A38-B2-C25;

A38-B2-C26;

A38-B2-C27;

A38-B2-C28;

A38-B2-C29;

A38-B2-C30;

A38-B2-C31;

A38-B2-C32;

A38-B2-C33;

A38-B2-C34;

A38-B2-C35;

A38-B2-C36;

A38-B2-C37;

A38-B2-C38;

A38-B2-C39;

A38-B2-C40;

A38-B2-C41;

A38-B2-C42;

A38-B2-C43;

A38-B2-C44;

A38-B2-C45;

A38-B2-C46;

A38-B2-C47;

A38-B2-C48;

A38-B2-C49;

A38-B2-C50;

A38-B2-C51;

A38-B2-C52;

A38-B2-C53;

A38-B2-C54;

A38-B2-C55;

A38-B2-C56;

A38-B2-C57;

A38-B2-C58;

A38-B2-C59;

A38-B2-C60;

A38-B2-C61;

A38-B2-C62;

A38-B2-C63;

A38-B2-C64;

A38-B2-C65;

A38-B2-C66;

A38-B2-C67;

A38-B2-C68;

A1-B3-C1;

A1-B3-C2;

A1-B3-C3;

A1-B3-C4;

A1-B3-C5;

A1-B3-C6;

A1-B3-C7;

A1-B3-C8;

A1-B3-C9; .

A1-B3-C10;

A1-B3-C11;

A1-B3-C12;

A1-B3-C13;

A1-B3-C14;

A1-B3-C15;

A1-B3-C16;

A1-B3-C17;

A1-B3-C18;

A1-B3-C19;

A1-B3-C20;

A1-B3-C21;

A1-B3-C22;

A1-B3-C23;

A1-B3-C24;

A1-B3-C25;

A1-B3-C26;

A1-B3-C27;

A1-B3-C28;

A1-B3-C29;

A1-B3-C30;

A1-B3-C31;

A1-B3-C32;

A1-B3-C33;

A1-B3-C34;

A1-B3-C35;

A1-B3-C36;

A1-B3-C37;

A1-B3-C38;

A1-B3-C39;

A1-B3-C40;

A1-B3-C41;

A1-B3-C42;

A1-B3-C43;

A1-B3-C44;

A1-B3-C45;

A1-B3-C46;

A1-B3-C47;

A1-B3-C48;

A1-B3-C49;

A1-B3-C50;

A1-B3-C51;

A1-B3-C52;

A1-B3-C53;

A1-B3-C54;

A1-B3-C55;

A1-B3-C56;

A1-B3-C57;

A1-B3-C58;

A1-B3-C59;

A1-B3-C60;

A1-B3-C61;

A1-B3-C62;

A1-B3-C63;

A1-B3-C64;

A1-B3-C65;

A1-B3-C66;

A1-B3-C67;

A1-B3-C68;

A2-B3-C1;

A2-B3-C2;

A2-B3-C3;

A2-B3-C4;

A2-B 3 -C 5;

A2-B3-C6;

A2-B3-C7;

A2-B3-C8;

A2-B3-C9;

A2-B3-C10;

A2-B3-C11;

A2-B3-C12;

A2-B3-C13;

A2-B3-C14;

A2-B3-C15;

A2-B3-C16;

A2-B3-C17;

A2-B3-C18;

A2-B3-C19;

A2-B3-C20;

A2-B3-C21;

A2-B3-C22;

A2-B3-C23;

A2-B3-C24;

A2-B3-C25;

A2-B3-C26;

A2-B3-C27;

A2-B3-C28;

A2-B3-C29;

A2-B3-C30;

A2-B3-C31;

A2-B3-C32;

A2-B3-C33;

A2-B3-C34;

A2-B3-C35;

A2-B3-C36;

A2-B3-C37;

A2-B3-C38;

A2-B3-C39;

A2-B3-C40;

A2-B3-C41;

A2-B3-C42;

A2-B3-C43;

A2-B3-C44;

• ·· · 9 · · ·

® Φ Φ · ® Φ Φ · ®

ΦΦΦ ΦΦΦ ΦΦ

-123ΦΦΦ ΦΦ Φφ ΦΦΦ Φ «ΦΦΦ

A2-B3-C45; A3-B3-C10; A3-B3-C43; A4-B3-C8; A4-B3-C41; A2-B3-C46; A3-B3-C11; A3-B3-C44; A4-B3-C9; A4-B3-C42; A2-B3-C47; A3-B3-C12; A3-B3-C45; A4-B3-C10; A4-B3-C43; A2-B3-C48; A3-B3-C13; A3-B3-C46; A4-B3-C11; A4-B3-C44; A2-B3-C49; A3-B3-C14; A3-B3-C47; A4-B3-C12; A4-B3-C45; A2-B3-C50; A3-B3-C15; A3-B3-C48; A4-B3-C13; A4-B3-C46; A2-B3-C51; A3-B3-C16; A3-B3-C49; A4-B3-C14; A4-B3-C47; A2-B3-C52; A3-B3-C17; A3-B3-C50; A4-B3-C15; A4-B3-C48; A2-B3-C53; A3-B3-C18; A3-B3-C51; A4-B3-C16; A4-B3-C49; A2-B3-C54; A3-B3-C19; A3-B3-C52; A4-B3-C17; A4-B3-C50; A2-B3-C55; A3-B3-C20; A3-B3-CS3; A4-B3-C18; A4-B3-C51; A2-B3-C56; A3-B3-C21; A3-B3-C54; A4-B3-C19; A4-B3-C52; A2-B3-C57; A3-B3-C22; A3-B3-C55; A4-B3-C20; A4-B3-C53; A2-B3-C58; A3-B3-C23; A3-B3-C55; A4-B3-C21; A4-B3-C54; A2-B3-C59; A3-B3-C24; A3-B3-C57; A4-B3-C22; A4-B3-C55; A2-B3-C60; A3-B3-C25; A3-B3-C58; A4-B3-C23; A4-B3-C55; A2-B3-C61; A3-B3-C26; A3-B3-C59; A4-B3-C24; A4-B3-C57; A2-B3-C62; A3-B3-C27; A3-B3-C60; A4-B3-C25; A4-B3-CS8; A2-B3-C63; A3-B3-C28; A3-B3-C61; A4-B3-C26; A4-B3-C59; A2-B3-C64; A3-B3-C29; A3-B3-C62; A4-B3-C27; A4-B3-C60; A2-B3-C65; A3-B3-C30; A3-B3-C63; A4-B3-C28; A4-B3-C61; A2-B3-C66; A3-B3-C31; A3-B3-C64; A4-B3-C29; A4-B3-C62; A2-B3-C67; A3-B3-C32; A3-B3-C65; A4-B3-C30; A4-B3-C63; A2-B3-C68; A3-B3-C33; A3-B3-C66; A4-B3-C31; A4-B3-C64; A3-B3-C1; A3-B3-C34; A3-B3-C67; A4-B3-C32; A4-B3-C65; A3-B3-C2; A3-B3-C35; A3-B3-C68; A4-B3-C33; A4-B3-C66; A3-B3-C3; ι A3-B3-C36; A4-B3-C1; A4-B3-C34; A4-B3-C67; A3-B3-C4; A3-B3-C37; A4-B3-C2; A4-B3-C35; A4-B3-C68; A3-B3-CS; A3-B3-C38; A4-B3-C3; A4-B3-C36; A5-B3-C1; A3-B3-C6; A3-B3-C39; A4-B3-C4; A4-B3-C37; A5-B3-C2; A3-B3-C7; A3-B3-C40; A4-B3-C5; A4-B3-C38; A5-B 3 -C 3; A3-B3-C8; A3-B3-C41; A4-B 3 -C 6; A4-B3-C39; A5-B3-C4; A3-B3-C9; A3-B3-C42; A4-B3-C7; A4-B3-C40; A5-B 3 -C 5;

-124- 9 99 • * · · 9 · · · 9 99 99 • 999 9,999 9 9 9 9 9 9 9 A5-B 3 -C 6; A5-B3-C39; A6-B3-C4; A6-B3-C37; A7-B3-C2; A5-B 3 -C 7; A5-B3-C40; A6-B3-C5; A6-B3-C38; A7-B3-C3; A5-B3-C7: A5-B3-C41; A6-B3-C6; A6-B3-C39; A7-B3-C4; A5-B3-C9; AS-B3-C42; A6-B3-C7; A6-B3-C40; A7-B3-C5; A5-B3-C10; A5-B3-C43; A6-B3-C8; A6-B3-C41; A7-B3-C6; A5-B3-C11; A5-B3-C44; A6-B3-C9; A6-B3-C42; A7-B3-C7; A5-B3-C12; A5-B3-C45; A6-B3-C10; A6-B3-C43; A7-B3-C8; A5-B3-C13; A5-B3-C46; A6-B3-C11; A6-B3-C44; A7-B3-C9; A5-B3-C14; A5-B3-C47; A6-B3-C12; A6-B3-C45; A7-B3-C10; A5-B3-C15; A5-B3-C48; A6-B3-C13; A6-B3-C46; A7-B3-C11; A5-B3-C16; A5-B3-C49; A6-B3-C14; A6-B3-C47; A7-B3-C12; A5-B3-C17; A5-B3-C50; A6-B3-C15; A6-B3-C48; A7-B3-C13; A5.B3-C18; A5-B3-C51; A6-B3-C16; A6-B3-C49; A7-B3-C14; A5-B3-C19; A5-B3-C52; A6-B3-C17; A6-B3-C50; A7-B3-C15; A5-B3-C20; A5-B3-C53; A6-B3-C18; A6-B3-C51; A7-B3-C16; A5-B3-C21; A5-B3-C54; A6-B3-C19; A6-B3-C52; A7-B3-C17; A5-B3-C22; A5-B3-C55; A6-B3-C20; A6-B3-C53; A7-B3-C18; A5-B3-C23; A5-B3-C56; A6-B3-C21; A6-B3-C54; A7-B3-C19; A5-B3-C24; A5-B3-C57; A6-B3-C22; A6-B3-C55; A7-B3-C20; A5-B3-C25; A5-B3-C58; A6-B3-C23; A6-B3-C55; A7-B3-C21; A5-B3-C26; A5-B3-C59; A6-B3-C24; A6-B3-C57; A7-B3-C22; A5-B3-C27; A5-B3-C60; A6-B3-C25; A6-B3-C58; A7-B3-C23; A5-B3-C28; A5-B3-C61; A6-B3-C26; A6-B3-C59; A7-B3-C24; A5-B3-C29; A5-B3-C62; A6-B3-C27; A6-B3-C60; A7-B3-C25; A5-B3-C30; A5-B3-C63; A6-B3-C28; A6-B3-C61; A7-B3-C26; A5-B3-C31; A5-B3-C64; A6-B3-C29; A6-B3-C62; A7-B3-C27; A5-B3-C32; A5-B3-C65; A6-B3-C30; A6-B3-C63; A7-B3-C28; A5-B3-C33; A5-B3-C66; A6-B3-C31; A6-B3-C64; A7-B3-C29; A5-B3-C34; A5-B3-C67; A6-B3-C32; A6-B3-C65; A7-B3-C30; A5-B3-C35; A5-B3-C68; A6-B3-C33; A6-B3-C66; A7-B3-C31; A5-B3-C36; A6-B3-C1; A6-B3-C34; A6-B3-C67; A7-B3-C32; A5-B3-C37; A6-B3-C2; A6-B3-C35; A6-B3-C68; A7-B3-C33; A5-B3-C38; A6-B3-C3; A6-B3-C36; A7-B3-C1; A7-B3-C34;

-125φφφ φ · · φ ·· φφφ φφ φ

A7-B3-C35;

A7-B3-C36;

A7-B3-C37;

A7-B3-C38;

A7-B3-C39;

77-B3-C40;

77-B3-C41;

A7-B3-C42;

A7-B3-C43;

A7-B3-C44;

A7-B3-C45;

A7-B3-C46;

A7-B3-C47;

77-B3-C48;

A7-B3-C49;

A7-B3-C50;

A7-B3-C51;

77-B3-C52;

A7-B3-C53;

A7-B3-C54;

A7-B3-C55;

A7-B3-C56;

A7-B3-C57;

A7-B3-C58;

A7-B3-C59;

A7-B3-C60;

A7-B3-C11;

A7-B3-C62;

A7-B3-C63;

A7-B3-C64;

A7-B3-C65;

A7-B3-C66;

A7-B3-C67;

A7-B3-C68;

A8-B3-C1;

A8-B3-C2;

A8-B3-C3;

A8-B3-C4;

A8-B3-C5;

A8-B3-C6;

A8-B3-C7;

A8-B3-C8;

A8-B3-C9;

A8-B3-C10;

A8-B3-C11;

A8-B3-C12;

A8-B3-C13;

A8-B3-C14;

A8-B3-C15;

A8-B3-C16;

A8-B3-C17;

A8-B3-C18;

A8-B3-C19;

A8-B3-C20;

A8-B3-C21;

A8-B3-C22;

A8-B3-C23;

A8-B3-C24;

A8-B3-C25;

A8-B3-C26;

A8-B3-C27;

A8-B3-C28;

A8-B3-C29;

A8-B3-C30;

A8-B3-C31;

A8-B3-C32;

A8-B3-C33;

A8-B3-C34;

A8-B3-C35;

A8-B3-C36;

A8-B3-C37;

A8-B3-C38;

A8-B3-C39;

A8-B3-C40;

A8-B3-C41;

A8-B3-C42;

A8-B3-C43;

A8-B3-C44;

A8-B3-C45;

A8-B3-C46;

A8-B3-C47;

88-B3-C48;

88-B3-C49;

A8-B3-C50;

A8-B3-C51;

88-B3-C52;

A8-B3-C53;

A8-B3-C54;

A8-B3-C55;

A8-B3-C56;

A8-B3-C57;

88-B3-C58;

A8-B3-C59;

A8-B3-C60;

A8-B3-C61;

A8-B3-C62;

A8-B3-C63;

88-B3-C64;

A8-B3-C65;

A8-B3-C66;

A8-B3-C67;

A8-B3-C68;

A9-B3-C1;

A9-B3-C2;

A9-B3-C3;

9 9 -B 3 -C 4;

A9-B3-C5;

A9-B3-C6;

A9-B3-C7;

99-B3-C8;

A9-B3-C9;

99-B3-C10;

A9-B3-C11;

99-B3-C12;

A9-B3-C13;

A9-B3-C14;

99-B3-C15;

99-B3-C16;

A9-B3-C17;

99-B3-C18;

99-B3-C19;

A9-B3-C20;

99-B3-C21;

A9-B3-C22;

99-B3-C23;

99-B3-C24;

99-B3-C25;

A9-B3-C26;

99-B3-C27;

A9-B3-C28;

A9-B3-C29;

99-B3-C30;

99-B3-C31;

99-B3-C32;

99-B3-C33;

99-B3-C34;

99-B3-C35;

99-B3-C36;

99-B3-C37;

99-B3-C38;

99-B3-C39;

99-B3-C40;

99-B3-C41;

99-B3-C42;

99-B3-C43;

99-B3-C44;

99-B3-C45;

99-B3-C46;

99-B3-C47;

99-B3-C48;

99-B3-C49;

99-B3-C50;

99-B3-C51;

99-B3-C52;

99-B3-C53;

99-B3-C54;

99-B3-C55;

99-B3-C56;

99-B3-C57;

99-B3-C58;

99-B3-C59;

99-B3-C60;

99-B3-C61;

99-B3-C62;

99-B3-C63;

-126 -

99-B3-C64;

99-B3-C65;

99-B3-C66;

99-B3-C67;

A9-B3-C68;

A10-B3-C1;

A10-B3-C2;

A10-B3-C3;

A10-B3-C4;

A10-B3-C5;

A10-B3-C6;

A10-B3-C7;

A10-B3-C8;

A10-B3-C9;

A10-B3-C10;

A10-B3-C11;

A10-B3-C12;

A10-B3-C13;

A10-B3-C14;

A10-B3-C15;

A10-B3-C16;

A10-B3-C17;

A10-B3-C18;

A10-B3-C19;

A10-B3-C20;

A10-B3-C21;

A10-B3-C22;

A10-B3-C23;

A10-B3-C24;

A10-B3-C25;

A10-B3-C26;

A10-B3-C27;

A10-B3-C28;

A10-B3-C29;

A10-B3-C30;

A10-B3-C31;

A10-B3-C32;

A10-B3-C33;

A10-B3-C34;

A10-B3-C35;

A10-B3-C36;

A10-B3-C37;

A10-B3-C38;

A10-B3-C39;

A10-B3-C40;

A10-B3-C41;

A10-B3-C42;

A10-B3-C43;

A10-B3-C44;

A10-B3-C45;

A10-B3-C46;

A10-B3-C47;

A10-B3-C48;

A10-B3-C49;

A10-B3-C50;

A10-B3-C51;

A10-B3-C52;

A10-B3-C53;

A10-B3-C54;

A10-B3-C55;

A10-B3-CS6;

A10-B3-C57;

A10-B3-C58;

A10-B3-C59;

A10-B3-C60;

A10-B3-C61;

A10-B3-C62;

A10-B3-C63;

A10-B3-C64;

A10-B3-C65;

A10-B3-C66;

A10-B3-C67;

A10-B3-C68;

A11-B3-C1;

A11-B3-C2;

A11-B3-C3;

A11-B3-C4;

A11-B3-C5;

A11-B3-C6;

A11-B3-C7;

A11-B3-C8;

A11-B3-C9;

A11-B3-C10;

A11-B3-C11;

A11-B3-C12;

A11-B3-C13;

A11-B3-C14;

A11-B3-C15;

A11-B3-C16;

A11-B3-C17;

A11-B3-C18;

A11-B3-C19;

A11-B3-C20;

A11-B3-C21;

A11-B3-C22;

A11-B3-C23;

AX1-B3-C24;

AXI-B3-C25;

AXX-B3-C26

A11-B3-C27;

A11-B3-C28;

A11-B3-C29;

A11-B3-C30;

A11-B3-C31;

A11-B3-C32;

A11-B3-C33;

AXX-B3-C33;

AXX-B3-C40;

A11-B3-C36;

AXX-B3-C36;

AXX-B3-C38;

A11-B3-C39;

A11-B3-C40;

A11-B3-C41;

AXX-B3-C41;

A11-B3-C43;

A11-B3-C44;

A11-B3-C45;

A11-B3-C46;

A11-B3-C47;

A11-B3-C48;

A11-B3-C49;

A11-B3-C50;

A11-B3-C51;

A11-B3-C52;

AXX-B3-C53

AXI-B3-C54;

AIX-B3-C55;

AII-B3-C56;

AXI-B3-C58;

AXI-B3-C58;

AXI-B3-C59;

AXX-B3-C60;

A11-B3-C61;

A11-B3-C62;

A11-B3-C63;

A11-B3-C64;

AXX-B3-C65

A11-B3-C66;

A11-B3-C67;

A11-B3-C68;

A12-B3-C1;

A12-B3-C2;

AX2-B3-C3;

A12-B3-C4;

AX2-B3-C4;

A12-B3-C6;

AX2-B3-C8;

A12-B3-C8;

A12-B3-C9;

A12-B3-C10;

A12-B3-C11;

A12-B3-C12;

A12-B3-C13;

A12-B3-C14;

AX2-B3-CX4;

A12-B3-C16;

A12-B3-C17;

A12-B3-C18;

A12-B3-C19;

A12-B3-C20;

A12-B3-C21;

A12-B3-C22;

A12-B3-C23;

A12-B3-C24;

- 127 9 9 · 9 «« · · · «127 127 127 127 127 127 127 127 127 127 127 127 127 127 127 127

A12-B3-C25;

A12-B3-C26;

A12-B3-C27;

A12-B3-C28;

A12-B3-C29;

A12-B3-C30;

A12-B3-C31;

A12-B3-C32;

A12-B3-C33;

A12-B3-C34;

A12-B3-C35;

A12-B3-C36;

A12-B3-C37;

A12-B3-C38;

A12-B3-C39;

A12-B3-C40;

A12-B3-C41;

A12-B3-C42;

A12-B3-C43;

A12-B3-C44;

A12-B3-C45;

A12-B3-C46;

A12-B3-C47;

A12-B3-C48;

A12-B3-C49;

A12-B3-C50;

A12-B3-C51;

A12-B3-C52;

A12-B3-C53;

A12-B3-C54;

A12-B3-C55;

A12-B3-C56;

A12-B3-C57;

A12-B3-C58;

A12-B3-C59;

A12-B3-C60;

A12-B3-C61;

A12-B3-C62;

A12-B3-C63;

A12-B3-C64;

A12-B3-C65;

A12-B3-C66;

A12-B3-C67;

A12-B3-C68;

A13-B3-C1;

A13-B3-C2;

A13-B3-C3;

A13-B3-C4;

A13-B3-C5;

A13-B3-C6;

A13-B3-C7;

A13-B3-C8;

A13-B3-C9;

A13-B3-C10;

A13-B3-C11;

A13-B3-C12;

A13-B3-C13;

A13-B3-C14;

A13-B3-C15;

A13-B3-C16;

A13-B3-C17;

A13-B3-C18;

A13-B3-C19;

A13-B3-C20;

A13-B3-C21;

A13-B3-C22;

A13-B3-C23;

A13-B3-C24;

A13-B3-C25;

A13-B3-C26;

A13-B3-C27;

A13-B3-C28;

A13-B3-C29;

A13-B3-C30;

A13-B3-C31;

A13-B3-C32;

A13-B3-C33;

A13-B3-C34;

A13-B3-C35;

A13-B3-C36;

A13-B3-C37;

A13-B3-C38;

A13-B3-C39;

A13-B3-C40;

A13-B3-C41;

A13-B3-C42;

A13-B3-C43;

A13-B3-C44;

A13-B3-C45;

A13-B3-C46;

A13-B3-C47;

A13-B3-C48;

A13-B3-C49;

A13-B3-C50;

A13-B3-C51;

A13-B3-C52;

A13-B3-C53;

A13-B3-C54;

A13-B3-C55;

A13-B3-C56;

A13-B3-C57;

A13-B3-C58;

A13-B3-C59;

A13-B3-C60;

A13-B3-C61;

A13-B3-C62;

A13-B3-C63;

A13-B3-C64;

A13-B3-C65;

A13-B3-C66;

A13-B3-C67;

A13-B3-C68;

A14-B3-C1;

A14-B3-C2;

A14-B3-C3;

A14-B3-C4;

A14-B3-C5;

A14-B3-C6;

A14-B3-C7;

A14-B3-C7:

A14-B3-C9;

A14-B3-C10;

A14-B3-C11;

A14-B3-C12;

A14-B3-C13;

A14-B3-C14;

A14-B3-C15;

A14-B3-C16;

A14-B3-C17;

A14-B3-C18;

A14-B3-C19;

A14-B3-C20;

A14-B3-C21;

A14-B3-C22;

A14-B3-C23;

A14-B3-C24;

A14-B3-C25;

A14-B3-C26;

A14-B3-C27;

A14-B3-C28;

A14-B3-C29;

A14-B3-C30;

A14-B3-C31;

A14-B3-C32;

A14-B3-C33;

A14-B3-C34;

A14-B3-C3S;

A14-B3-C36;

A14-B3-C37;

A14-B3-C38;

A14-B3-C39;

A14-B3-C40;

A14-B3-C41;

A14-B3-C42;

A14-B3-C43;

A14-B3-C44;

A14-B3-C45;

A14-B3-C46;

A14-B3-C47;

A14-B3-C48;

A14-B3-C49;

A14-B3-C50;

A14-B3-C51;

A14-B3-C52;

A14-B3-C53;

·· · · · · · · · · · · · · · · ·

- 128-

·· ·

A14-B3-C54;

A14-B3-C55;

A14-B3-C56;

A14-B3-C57;

A14-B3-C58;

A14-B3-C59;

A14-B3-C60;

A14-B3-C61;

A14-B3-C62;

A14-B3-C63;

A14-B3-C64;

A14-B3-C65;

A14-B3-C66;

A14-B3-C67;

A14-B3-C68;

A15-B3-C1;

A15-B3-C2;

A15-B3-C3;

A15-B3-C4;

A15-B3-C5;

A15-B3-C6;

A15-B3-C7;

A15-B3-C8;

A15-B3-C9;

A15-B3-C10;

A15-B3-C11;

A15-B3-Q2;

A15-B3-C13;

A15-B3-C14;

A15-B3-C15;

A15-B3-C16;

A15-B3-C17;

A15-B3-C18;

A15-B3-C19;

A15-B3-C20;

A15-B3-C21;

A15-B3-C22;

A15-B3-C23;

A15-B3-C24;

A15-B3-C25;

A15-B3-C26;

A15-B3-C27;

A15-B3-C28;

A15-B3-C29;

A15-B3-C30;

A15-B3-C31;

A15-B3-C32;

A15-B3-C33;

A15-B3-C34;

A15-B3-C35;

A15-B3-C36;

A15-B3-C37;

A15-B3-C38;

A15-B3-C39;

A15-B3-C40;

A15-B3-C41;

A15-B3-C42;

A15-B3-C43;

A15-B3-C44;

A15-B3-C45;

A15-B3-C46;

A15-B3-C47;

A15-B3-C48;

A15-B3-C49;

A15-B3-C50;

A15-B3-C51;

A15-B3-C52;

A15-B3-C53;

A15-B3-C54;

A15-B3-C55;

A15-B3-C56;

A15-B3-C57;

A15-B3-C58;

A15-B3-C59;

A15-B3-C60;

A15-B3-C61;

A15-B3-C62;

A15-B3-C63;

A15-B3-C64;

A15-B3-C65;

A15-B3-C66;

A15-B3-C67;

A15-B3-C68;

A16-B3-C1;

A16-B3-C2;

A16-B3-C3;

A16-B3-C4;

A16-B3-C5;

A16-B3-C6;

A16-B3-C7;

A16-B3-C8;

A16-B3-C9;

A16-B3-C10;

A16-B3-C11;

A16-B3-C12;

A16-B3-C13;

A16-B3-C14;

A16-B3-C15;

A16-B3-C16;

A16-B3-C17;

A16-B3-C18;

A16-B3-C19;

A16-B3-C20;

A16-B3-C21;

A16-B3-C22;

A16-B3-C23;

A16-B3-C24;

A16-B3-C25;

A16-B3-C26;

A16-B3-C27;

A16-B3-C28;

A16-B3-C29;

A16-B3-C30;

A16-B3-C31;

A16-B3-C32;

A16-B3-C33;

A16-B3-C34;

A16-B3-C35;

A16-B3-C36;

A16-B3-C37;

A16-B3-C38;

A16-B3-C39;

A16-B3-C40;

A16-B3-C41;

A16-B3-C42;

A16-B3-C43;

A16-B3-C44;

A16-B3-C45;

A16-B3-C46;

A16-B3-C47;

A16-B3-C48;

A16-B3-C49;

A16-B3-C50;

A16-B3-C51;

A16-B3-C52;

A16-B3-C53;

A16-B3-C54;

A16-B3-C55;

A16-B3-C56;

A16-B3-C57;

A16-B3-C58;

A16-B3-C59;

A16-B3-C60;

A16-B3-C61;

A16-B3-C62;

A16-B3-C63;

A16-B3-C64;

1616-B3-C65;

A16-B3-C66;

A16-B3-C67;

A16-B3-C68;

A17-B3-C1;

A17-B3-C2;

A17-B3-C3;

A17-B3-C4

A17-B3-C5;

A17-B3-C6;

A17-B3-C7;

A17-B3-C8;

A17-B3-C9;

A17-B3-C10;

A17-B3-C11;

A17-B3-C12;

A17-B3-C13;

A17-B3-C14;

• 99 99 99 • 99 99

- 129 • 9 9 9 9 9 9 99 99 999 99 999

A17-B3-C15;

A17-B3-C16;

A17-B3-C17;

A17-B3-C18;

A17-B3-C19;

A17-B3-C20;

A17-B3-C21;

A17-B3-C22;

A17-B3-C23;

A17-B3-C24;

A17-B3-C25;

A17-B3-C26;

A17-B3-C27;

A17-B3-C28;

A17-B3-C29;

A17-B3-C30;

A17-B3-C3I;

A17-B3-C32;

A17-B3-C33;

A17-B3-C34;

A17-B3-C35;

A17-B3-C36;

A17-B3-C37;

A17-B3-C38;

A17-B3-C39;

A17-B3-C40;

A17-B3-C41;

A17-B3-C42;

A17-B3-C43;

A17-B3-C44;

A17-B3-C45;

A17-B3-C46;

A17-B3-C47;

A17-B3-C48;

A17-B3-C49;

A17-B3-C50;

A17-B3-C51;

A17-B3-C52;

A17-B3-C53;

A17-B3-CS4;

A17-B3-C55;

A17-B3-C56;

A17-B3-C57;

A17-B3-C58;

A17-B3-C59;

A17-B3-C60;

A17-B3-C61;

A17-B3-C62;

A17-B3-C63;

A17-B3-C64;

A17-B3-C65;

A17-B3-C66;

A17-B3-C67;

A17-B3-C68;

A18-B3-C1;

A18-B3-C2;

A18-B3-C3;

A18-B3-C4;

A18-B3-C5;

A18-B3-C6;

A18-B3-C7;

A18-B3-C8;

A18-B3-C9;

A18-B3-C10;

A18-B3-C11;

A18-B3-C12;

A18-B3-C13;

A18-B3-C14;

A18-B3-C15;

A18-B3-C16;

A18-B3-C17;

A18-B3-C18;

A18-B3-C19;

A18-B3-C20;

A18-B3-C21;

A18-B3-C22;

A18-B3-C23;

A18-B3-C24;

A18-B3-C25;

A18-B3-C26;

A18-B3-C27;

A18-B3-C28;

A18-B3-C29;

A18-B3-C30;

A18-B3-C31;

A18-B3-C32;

A18-B3-C33;

A18-B3-C34;

A18-B3-C35;

A18-B3-C36;

A18-B3-C37;

A18-B3-C38;

A18-B3-C39;

A18-B3-C40;

A18-B3-C41;

A18-B3-C42;

A18-B3-C43;

A18-B3-C44;

A18-B3-C45;

A18-B3-C46;

A18-B3-C47;

A18-B3-C48;

A18-B3-C49;

A18-B3-C50;

A18-B3-C51;

A18-B3-C52;

A18-B3-C53;

A18-B3-C54;

A18-B3-C55;

A18-B3-C56;

A18-B3-C57;

A18-B3-C58;

A18-B3-C59;

A18-B3-C60;

A18-B3-C61;

A18-B3-C62;

A18-B3-C63;

A18-B3-C64;

A18-B3-C65;

A18-B3-C66;

A18-B3-C67;

A18-B3-C68;

A19-B3-C1;

A19-B3-C2;

A19-B3-C3;

A19-B3-C4;

A19-B3-C5;

A19-B3-C6;

A19-B3-C7;

A19-B3-C8;

A19-B3-C9;

A19-B3-C10;

A19-B3-C11;

A19-B3-C12;

A19-B3-C13;

A19-B3-C14;

A19-B3-C15;

A19-B3-C16;

A19-B3-C17;

A19-B3-C18;

A19-B3-C19;

A19-B3-C20;

A19-B3-C21;

A19-B3-C22;

A19-B3-C23;

A19-B3-C24;

A19-B3-C25;

A19-B3-C26;

A19-B3-C27;

A19-B3-C28;

A19-B3-C29;

A19-B3-C30;

A19-B3-C31;

A19-B3-C32;

A19-B3-C33;

A19-B3-C34;

A19-B3-C35;

A19-B3-C36;

A19-B3-C37;

A19-B3-C38;

A19-B3-C39;

A19-B3-C40;

A19-B3-C41;

A19-B3-C42;

A19-B3-C43;

-130.

A19-B3-C44; A20-B3-C9; A20-B3-C42; A21-B3-C7; A21-B3-C40; A19-B3-C45; A20-B3-C10; A20-B3-C43; A21-B3-C8; A21-B3-C41; A19-B3-C46; A20-B3-C11; A20-B3-C44; A21-B3-C9; A21-B3-C42; A19-B3-C47; A20-B3-C12; A20-B3-C45; A21-B3-C10; A21-B3-C43; A19-B3-C48; A20-B3-C13; A20-B3-C46; A21-B3-C11; A21-B3-C44; A19-B3-C49; A20-B3-C14; A20-B3-C47; A21-B3-C12; A21-B3-C45; A19-B3-C50; A20-B3-C15; A20-B3-C48; A21-B3-C13; A21-B3-C46; A19-B3-C51; A20-B3-C16; A20-B3-C49; A21-B3-C14; A21-B3-C47; A19-B3-C52; A20-B3-C17; A20-B3-C50; A21-B3-C15; A21-B3-C48; A19-B3-C53; A20-B3-C18; A20-B3-C51; A21-B3-C16; A21-B3-C49; A19-B3-C54; A20-B3-C19; A20-B3-C52; A21-B3-C17; A21-B3-C50; A19-B3-C55; A20-B3-C20; A20-B3-C53; A21-B3-C18; A21-B3-C51; A19-B3-C56; A20-B3-C21; A20-B3-C54; A21-B3-C19; A21-B3-C52; A19-B3-C57; A20-B3-C22; A20-B3-C55; A21-B3-C20; A21-B3-C53; A19-B3-C58; A20-B3-C23; A20-B3-C56; A21-B3-C21; A21-B3-C54; A19-B3-C59; A20-B3-C24; A20-B3-C57; A21-B3-C22; A21-B3-C55; A19-B3-C60; A20-B3-C25; A20-B3-C58; A21-B3-C23; A21-B3-C56; A19-B3-C61; A20-B3-C26; A20-B3-C59; A21-B3-C24; A21-B3-C57; A19-B3-C62; A20-B3-C27; A20-B3-C60; A21-B3-C25; A21-B3-C58; A19-B3-C63; A20-B3-C28; A20-B3-C61; A21-B3-C26; A21-B3-C59; A19-B3-C64; A20-B3-C29; A20-B3-C62; A21-B3-C27; A21-B3-C60; A19-B3-C65; A20-B3-C30; A20-B3-C63; A21-B3-C28; A21-B3-C61; A19-B3-C66; A20-B3-C31; A20-B3-C64; A21-B3-C29; A21-B3-C62; A19-B3-C67; A20-B3-C32; A20-B3-C65; A21-B3-C30; A21-B3-C63; A19-B3-C68; A20-B3-C33; A20-B3-C66; A21-B3-C31; A21-B3-C64; A20-B3-C1; A20-B3-C34; A20-B3-C67; A21-B3-C32; A21-B3-C65; A20-B3-JC2; A20-B3-C35; A20-B3-C68; A21-B3-C33; A21-B3-C66; A20-B3-C3; A20-B3-C36; A21-B3-C1; A21-B3-C34; A21-B3-C67; A20-B3-C4; A20-B3-C37; A21-B3-C2; A21-B3-C35; A21-B3-C68; A20-B3-C5; A20-B3-C38; A21-B3-C3; A21-B3-C36; A22-B3-C1; A20-B3-C6; A20-B3-C39; A21-B3-C4; A21-B3-C37; A22-B3-C2; A20-B3-C7; A20-B3-C40; A21-B3-C5; A21-B3-C38; A22-B3-C3; A20-B3-C8; A20-B3-C41; A21-B3-C6; A21-B3-C39; A22-B3-C4;

· · · · · · · · · · · · · · · · · · · · ·

- 131 • · · · · · · · · · · · · · · · · · · · · · · ·

A22-B3-C5; A22-B3-C38; A23-B3-C3; A23-B3-C36; A24-B3-C1; A22-B3-C6; A22-B3-C39; A23-B3-C4; A23-B3-C37; A24-B3-C2; A22-B3-C7; A22-B3-C40; A23-B3-C5; A23-B3-C38; A24-B3-C3; A22-B3-C8; A22-B3-C41; A23-B3-C6; A23-B3-C39; A24-B3-C4; A22-B3-C9; A22-B3-C42; A23-B3-C7; A23-B3-C40; A24-B3-C5; A22-B3-C10; A22-B3-C43; A23-B3-C8; A23-B3-C41; A24-B3-C6; A22-B3-C11; A22-B3-C44; A23-B3-C9; A23-B3-C42; A24-B3-C7; A22-B3-C12; A22-B3-C45; A23-B3-C10; A23-B3-C43; A24-B3-C8; A22-B3-C13; A22-B3-C46; A23-B3-C11; A23-B3-C44; A24-B3-C9; A22-B3-C14; A22-B3-C47; A23-B3-C12; A23-B3-C45; A24-B3-C10; A22-B3-C15; A22-B3-C48; A23-B3-C13; A23-B3-C46; A24-B3-C11; A22-B3-C16; A22-B3-C49; A23-B3-C14; A23-B3-C47; A24-B3-C12; A22-B3-C17; A22-B3-C50; A23-B3-C15; A23-B3-C48; A24-B3-C13; A22-B3-C18; A22-B3-C51; A23-B3-C16; A23-B3-C49; A24-B3-C14; A22-B3-C19; A22-B3-C52; A23-B3-C17; A23-B3-C50; A24-B3-C15; A22-B3-C20; A22-B3-C53; A23-B3-C18; A23-B3-C51; A24-B3-C16; A22-B3-C21; A22-B3-C54; A23-B3-C19; A23-B3-C52; A24-B3-C17; A22-B3-C22; A22-B3-C55; A23-B3-C20; A23-B3-C53; A24-B3-C18; A22-B3-C23; A22-B3-C56; A23-B3-C21; A23-B3-C54; A24-B3-C19; A22-B3-C24; A22-B3-C57; A23-B3-C22; A23-B3-C55; A24-B3-C20; A22-B3-C25; A22-B3-C58; A23-B3-C23; A23-B3-C56; A24-B3-C21; A22-B3-C26; A22-B3-C59; A23-B3-C24; A23-B3-C57; A24-B3-C22; A22-B3-C27; A22-B3-C60; A23-B3-C25; A23-B3-C58; A24-B3-C23; A22-B3-C28; A22-B3-C61; A23-B3-C26; A23-B3-C59; A24-B3-C24; A22-B3-C29; A22-B3-C62; A23-B3-C27; A23-B3-C60; A24-B3-C25; A22-B3-C30; A22-B3-C63; A23-B3-C28; A23-B3-C61; A24-B3-C26; A22-B3-C31; A22-B3-C64; A23-B3-C29; A23-B3-C62; A24-B3-C27; A22-B3-C32; A22-B3-C65; A23-B3-C30; A23-B3-C63; A24-B3-C28; A22-B3-C33; A22-B3-C66; A23-B3-C31; A23-B3-C64; A24-B3-C29; A22-B3-C34; A22-B3-C67; A23-B3-C32; A23-B3-C65; A24-B3-C30; A22-B3-C35; A22-B3-C68; A23-B3-C33; A23-B3-C66; A24-B3-C31; A22-B3-C36; A23-B3-C1; A23-B3-C34; A23-B3-C67; A24-B3-C32; A22-B3-C37; A23-B3-C2; A23-B3-C35; A23-B3-C68; A24-B3-C33;

-132-

A24-B3-C34;

A24-B3-C35;

A24-B3-C36;

A24-B3-C37;

A24-B3-C38;

A24-B3-C39;

A24-B3-C40;

A24-B3-C41;

A24-B3-C42;

A24-B3-C43;

A24-B3-C44;

A24-B3-C45;

A24-B3-C46;

A24-B3-C47;

A24-B3-C48;

A24-B3-C49;

A24-B3-C50;

A24-B3-C51;

A24-B3-C52;

A24-B3-C53;

A24-B3-C54;

A24-B3-C55;

A24-B3-C56;

A24-B3-C57;

A24-B3-C58;

A24-B3-C59;

A24-B3-C60;

A24-B3-C61;

A24-B3-C62;

A24-B3-C63;

A24-B3-C64;

A24-B3-C65;

A24-B3-C66;

A24-B3-C67;

A24-B3-C68;

A25-B3-C1;

A25-B3-C2;

A25-B3-C3;

A25-B3-C4;

A25-B3-C5;

A25-B3-C6;

A25-B3-C7;

A25-B3-C8;

A25-B3-C9;

A25-B3-C10;

A25-B3-C11;

A25-B3-C12;

A25-B3-C13;

A25-B3-C14;

A25-B3-C15;

A25-B3-C16;

A25-B3-C17;

A25-B3-C18;

A25-B3-C19;

A25-B3-C20;

A25-B3-C21;

A25-B3-C22;

A25-B3-C23;

A25-B3-C24;

A25-B3-C25;

A25-B3-C26;

A25-B3-C27;

A25-B3-C28;

A25-B3-C29;

A25-B3-C30;

A2S-B3-C31;

A25-B3-C32;

A25-B3-C33;

A25-B3-C34;

A25-B3-C35;

A25-B3-C36;

A25-B3-C37;

A25-B3-C38;

A25-B3-C39;

A25-B3-C40;

A25-B3-C41;

A25-B3-C42;

A25-B3-C43;

A25-B3-C44;

A25-B3-C45;

A25-B3-C46;

A25-B3-C47;

A25-B3-C48;

A25-B3-C49;

A25-B3-C50;

A25-B3-C51;

A25-B3-C52;

A25-B3-C53;

A25-B3-C54;

A25-B3-C55;

A25-B3-C56;

A25-B3-C57;

A25-B3-C58;

A25-B3-C59;

A25-B3-C60;

A25-B3-C61;

A25-B3-C62;

A25-B3-C63;

A25-B3-C64;

A25-B3-C65;

A25-B3-C66;

A25-B3-C67;

A25-B3-C68;

A26-B3-C1;

A26-B3-C2;

A26-B3-C3;

A26-B3-C4;

A26-B3-C5;

A26-B3-C6;

A26-B3-C7;

A26-B3-C8;

A26-B3-C9;

A26-B3-C10;

A26-B3-C11;

A26-B3-C12;

A26-B3-C13;

A26-B3-C14;

A26-B3-C15;

A26-B3-C16;

A26-B3-C17;

A26-B3-C18;

A26-B3-C19;

A26-B3-C20;

A26-B3-C21;

A26-B3-C22;

A26-B3-C23;

A26-B3-C24;

A26-B3-C25;

A26-B3-C26;

A26-B3-C27;

A26-B3-C28;

A26-B3-C29;

A26-B3-C30;

A26-B3-C31;

A26-B3-C32;

A26-B3-C33;

A26-B3-C34;

A26-B3-C35;

A26-B3-C36;

A26-B3-C37;

A26-B3-C38;

A26-B3-C39;

A26-B3-C40;

A26-B3-C41;

A26-B3-C42;

A26-B3-C43;

A26-B3-C44;

A26-B3-C45;

A26-B3-C46;

A26-B3-C47;

A26-B3-C48;

A26-B3-C49;

A26-B3-C50;

A26-B3-C51;

A26-B3-C52;

A26-B3-C53;

A26-B3-C54;

A26-B3-C55;

A26-B3-C56;

A26-B3-C57;

A26-B3-C58;

A26-B3-C59;

A26-B3-C60;

A26-B3-C61;

A26-B3-C62;

«Tftf

-133 tff tff tff tff tff tff tff

A26-B3-C63;

A26-B3-C64;

A26-B3-C65;

A26-B3-C66;

A26-B3-C67;

A26-B3-C68;

A27-B3-C1;

A27-B3-C2;

A27-B3-C3;

A27-B3-C4;

A27-B3-C5;

A27-B3-C6;

A27-B3-C7;

A27-B3-C8;

A27-B3-C9;

A27-B3-C10;

A27-B3-C11;

A27-B3-C12;

A27-B3-C13;

A27-B3-C14;

A27-B3-C15;

A27-B3-C16;

A27-B3-C17;

A27-B3-C18;

A27-B3-C19;

A27-B3-C20;

A27-B3-C21;

AND

A27-B3-C22;

A27-B3-C23;

A27-B3-C24;

A27-B3-C25;

A27-B3-C26;

A27-B3-C27;

A27-B3-C28;

A27-B3-C29;

A27-B3-C30;

A27-B3-C31;

A27-B3-C32;

A27-B3-C33;

A27-B3-C34;

A27-B3-C35;

A27-B3-C36;

A27-B3-C37;

A27-B3-C38;

A27-B3-C39;

A27-B3-C40;

A27-B3-C41;

A27-B3-C42;

A27-B3-C43;

A27-B3-C44;

A27-B3-C45;

A27-B3-C46;

A27-B3-C47;

A27-B3-C48;

A27-B3-C49;

A27-B3-C50;

A27-B3-C51;

A27-B3-C52;

A27-B3-C53;

A27-B3-C54;

A27-B3-C55;

A27-B3-C56;

A27-B3-C57;

A27-B3-C58;

A27-B3-C59;

A27-B3-C60;

A27-B3-C61;

A27-B3-C62;

A27-B3-C63;

A27-B3-C64;

A27-B3-C65;

A27-B3-C66;

A27-B3-C67;

A27-B3-C68;

A28-B3-C1;

A28-B3-C2;

A28-B3-C3;

A28-B3-C4;

A28-B3-C5;

A28-B3-C6;

A28-B3-C7;

A28-B3-C8;

A28-B3-C9;

A28-B3-C10;

A28-B3-C11;

A28-B3-C12;

A28-B3-C13;

Α28-Β3-4;

A28-B3-C15;

A28-B3-C16;

A28-B3-C17;

A28-B3-C18;

A28-B3-C19;

A28-B3-C20;

A28-B3-C21;

A28-B3-C22;

A28-B3-C23;

A28-B3-C24;

A28-B3-C25;

A28-B3-C26;

A28-B3-C27;

A28-B3-C28;

A28-B3-C29;

A28-B3-C30;

A28-B3-C31;

A28-B3-C32;

A28-B3-C33;

A28-B3-C34;

A28-B3-C35;

A28-B3-C36;

A28-B3-C37;

A28-B3-C38;

A28-B3-C39;

A28-B3-C40;

A28-B3-C41;

A28-B3-C42;

A28-B3-C43;

A28-B3-C44;

A28-B3-C45;

A28-B3-C46;

A28-B3-C47;

A28-B3-C48;

A28-B3-C49;

A28-B3-C50;

A28-B3-C51;

A28-B3-C52;

A28-B3-C53;

A28-B3-C54;

A28-B3-C55;

A28-B3-C56;

A28-B3-C57;

A28-B3-C58;

A28-B3-C59;

A28-B3-C60;

A28-B3-C61;

A28-B3-C62;

A28-B3-C63;

A28-B3-C64;

A28-B3-C65;

A28-B3-C66;

A28-B3-C67;

A28-B3-C68;

A29-B3-C1;

A29-B3-C2;

A29-B3-C3;

A29-B3-C4;

A29-B3-C5;

A29-B3-C6;

A29-B3-C7;

A29-B3-C8;

A29-B3-C9;

A29-B3-C10;

A29-B3-C11;

A29-B3-C12;

A29-B3-C13;

A29-B3-C14;

A29-B3-C15;

A29-B3-C16;

A29-B3-C17;

A29-B3-C18;

A29-B3-C19;

A29-B3-C20;

A29-B3-C21;

A29-B3-C22;

A29-B3-C23;

A29-B3-C24; A29-B3-C57; A30-B3-C22; A30-B3-C55; A31-B3-C20; A29-B3-C25; A29-B3-CS8; A30-B3-C23; A30-B3-C50; A31-B3-C21; A29-B3-C26; A29-B3-C59; A30-B3-C24; A30-B3-C57; A31-B3-C22; A29-B3-C27; A29-B3-C60; A30-B3-C2S; A30-B3-CS8; A31-B3-C23; A29-B3-C28; A29-B3-C61; A30-B3-C26; A30-B3-C59; A31-B3-C24; A29-B3-C29; A29-B3-C62; A30-B3-C27; A30-B3-C60; A31-B3-C25; A29-B3-C30; A29-B3-C63; A30-B3-C28; A30-B3-C61; A31-B3-C26; A29-B3-C31; A29-B3-C64; A30-B3-C29; A30-B3-C62; A31-B3-C27; A29-B3-C32; A29-B3-C65; A30-B3-C30; A30-B3-C63; A31-B3-C28; A29-B3-C33; A29-B3-C66; A30-B3-C31; A30-B3-C64; A31-B3-C29; A29-B3-C34; A29-B3-C67; A30-B3-C32; A30-B3-C65; A31-B3-C30; A29-B3-C35; A29-B3-C68; A30-B3-C33; A30-B3-C66; A31-B3-C31; A29-B3-C36; A30-B3-C1; A30-B3-C34; A30-B3-C67; A31-B3-C32; A29-B3-C37; A30-B3-C2; A30-B3-C35; A30-B3-C68; A31-B3-C33; A29-B3-C38; A30-B3-C3; A30-B3-C36; A31-B3-C1; A31-B3-C34; A29-B3-C39; A30-B3-C4; A30-B3-C37; A31-B3-C2; A31-B3-C35; A29-B3-C40; A30-B3-C5; A30-B3-C38; A31-B3-C3; A31-B3-C36; A29-B3-C41; A30-B3-C6; A30-B3-C39; A31-B3-C4; A31-B3-C37; A29-B3-C42; A30-B3-C7; A30-B3-C40; A31-B3-C5; A31-B3-C38; A29-B3-C43; A30-B3-C8; A30-B3-C41; A31-B3-C6; A31-B3-C39; A29-B3-C44; A30-B3-C9; A30-B3-C42; A31-B3-C7; A31-B3-C40; A29-B3-C45; A30-B3-C10; A30-B3-C43; A31-B3-C8; A31-B3-C41; A24-B3-C46; A30-B3-C11; A30-B3-C44; A31-B3-C9; A31-B3-C42; A29-B3-C47; A30-B3-C12; A30-B3-C45; A31-B3-C10; A31-B3-C43; A29-B3-C48; A30-B3-C13; A30-B3-C46; A31-B3-C11; A31-B3-C44; A29-B3-C49; A30-B3-C14; A30-B3-C47; A31-B3-C12; A31-B3-C45; A29-B3-C50; A30-B3-C15; A30-B3-C48; A31-B3-C13; A31-B3-C46; A29-B3-C51; A30-B3-C16; A30-B3-C49; A31-B3-C14; A31-B3-C47; A29-B3-C52; A30-B3-C17; A30-B3-C50; A31-B3-C15; A31-B3-C48; A29-B3-C53; A30-B3-C18; A30-B3-C51; A31-B3-C16; A31-B3-C49; A29-B3-CS4; A30-B3-C19; A30-B3-C52; A31-B3-C17; A31-B3-C50; A29-B3-C55; A30-B3-C20; A30-B3-C53; A31-B3-C18; A31-B3-C51; A29-B3-C50; A30-B3-C21; A30-B3-C54; A31-B3-C19; A31-B3-C52;

-135 -

A31-B3-C53;

A31-B3-C54;

A31-B3-C55;

A31-B3-C56;

A31-B3-C57;

A31-B3-C58;

A31-B3-C59;

A31-B3-C60;

A31-B3-C61;

A31-B3-C62;

A31-B3-C63;

A31-B3-C64;

A31-B3-C65;

A31-B3-C66;

A31-B3-C67;

A31-B3-C68;

A32-B3-C1;

A32-B3-C2;

A32-B3-C3;

A32-B3-C4;

A32-B3-C5;

A32-B3-C6;

A32-B3-C7;

A32-B3-C8;

A32-B3-C9;

A32-B3-C10;

A32-B3-C11;

A32-B3-C12;

A32-B3-C13;

A32-B3-C14;

A32-B3-C15;

A32-B3-C16;

A32-B3-C17;

A32-B3-C18;

A32-B3-C19;

A32-B3-C20;

A32-B3-C21;

A32-B3-C22;

A32-B3-C23;

A32-B3-C24;

A32-B3-C25;

A32-B3-C26;

A32-B3-C27;

A32-B3-C28;

A32-B3-C29;

A32-B3-C30;

A32-B3-C31;

A32-B3-C32;

A32-B3-C33;

A32-B3-C34;

A32-B3-C35;

A32-B3-C36;

A32-B3-C37;

A32-B3-C38;

A32-B3-C39;

A32-B3-C40;

A32-B3-C41;

A32-B3-C42;

A32-B3-C43;

A32-B3-C44;

A32-B3-C45;

A32-B3-C46;

A32-B3-C47;

A32-B3-C48;

A32-B3-C49;

A32-B3-C50;

A32-B3-C51;

A32-B3-C52;

A32-B3-C53;

A32-B3-C54;

A32-B3-C55;

A32-B3-C56;

A32-B3-C57;

A32-B3-C58;

A32-B3-C59;

A32-B3-C60;

A32-B3-C61;

A32-B3-C62;

A32-B3-C63;

A32-B3-C64;

A32-B3-C65;

A32-B3-C66;

A32-B3-C67;

A32-B3-C68;

A33-B3-C1;

A33-B3-C2;

A33-B3-C3;

A33-B3-C4;

A33-B3-CS;

A33-B3-C6;

A33-B3-C7;

A33-B3-C8;

A33-B3-C9;

A33-B3-C10;

A33-B3-C11;

A33-B3-C12;

A33-B3-C13;

A33-B3-C14;

A33-B3-C15;

A33-B3-C16;

A33-B3-C17;

A33-B3-C18;

A33-B3-C19;

A33-B3-C20;

A33-B3-C21;

A33-B3-C22;

A33-B3-C23;

A33-B3-C24;

A33-B3-C25;

A33-B3-C26;

A33-B3-C27;

A33-B3-C28;

A33-B3-C29;

A33-B3-C30;

A33-B3-C31;

A33-B3-C32;

A33-B3-C33;

A33-B3-C34;

A33-B3-C35;

A33-B3-C36;

A33-B3-C37;

A33-B3-C38;

A33-B3-C39;

A33-B3-C40;

A33-B3-C41;

A33-B3-C42;

A33-B3-C43;

A33-B3-C44;

A33-B3-C45;

A33-B3-C46;

A33-B3-C47;

A33-B3-C48;

A33-B3-C50:

A33-B3-C50;

A33-B3-C51;

A33-B3-C52;

A33-B3-C53;

A33-B3-C54;

A33-B3-C55;

A33-B3-C56;

A33-B3-C57;

A33-B3-C58;

A33-B3-C59;

A33-B3-C60;

A33-B3-C61;

A33-B3-C62;

A33-B3-C63;

A33-B3-C64;

A33-B3-C65;

A33-B3-C66;

A33-B3-C67;

A33-B3-C68;

A34-B3-C1;

A34-B3-C2;

A34-B3-C3;

A34-B3-C4;

A34-B3-C5;

A34-B3-C6;

A34-B3-C7;

A34-B3-C8;

A34-B3-C9;

A34-B3-C10;

A34-B3-C11;

A34-B3-C12;

A34-B3-C13;

136A34-B3-C14;

A34-B3-C15;

A34-B3-C16;

A34-B3-C17;

A34-B3-C18;

A34-B3-C19;

A34-B3-C20;

A34-B3-C21;

A34-B3-C22;

A34-B3-C23;

A34-B3-C24;

A34-B3-C25;

A34-B3-C26;

A34-B3-C27;

A34-B3-C28;

A34-B3-C29;

A34-B3-C30;

A34-B3-C31;

A34-B3-C32;

A34-B3-C33;

A34-B3-C34;

A34-B3-C35;

A34-B3-C36;

A34-B3-C37;

A34-B3-C38;

A34-B3-C39;

A34-B3-C40;

A34-B3-C41;

A34-B3-C42;

A34-B3-C43;

A34-B3-C44;

A34-B3-C45;

A34-B3-C46;

A34-B3-C47;

A34-B3-C48;

A34-B3-C49;

A34-B3-C50;

A34-B3-C51;

A34-B3-C52;

A34-B3-C53;

A34-B3-C54;

A34-B3-C55;

A34-B3-C56;

A34-B3-C57;

A34-B3-C58;

A34-B3-C59;

A34-B3-C60;

A34-B3-C61;

A34-B3-C62;

A34-B3-C63;

A34-B3-C64;

A34-B3-C65;

A34-B3-C66;

A34-B3-C67;

A34-B3-C68;

A35-B3-C1;

A35-B3-C2;

A35-B3-C3;

A35-B3-C4;

A35-B3-C5;

A35-B3-C6;

A35-B3-C7;

A35-B3-C8;

A35-B3-C9;

A35-B3-C10;

A35-B3-C11;

A35-B3-C12;

A35-B3-C13;

A35-B3-C14;

A35-B3-C15;

A35-B3-C16;

A35-B3-C17;

A35-B3-C18;

A35-B3-C19;

A35-B3-C20;

A35-B3-C21;

A35-B3-C22;

A35-B3-C23;

A35-B3-C24;

A35-B3-C25;

A35-B3-C26;

A35-B3-C27;

A35-B3-C28;

A35-B3-C29;

A35-B3-C30;

A35-B3-C31;

A35-B3-C32;

A35-B3-C33;

A35-B3-C34;

A35-B3-C35;

A35-B3-C36;

A35-B3-C37;

A35-B3-C38;

A35-B3-C39;

A35-B3-C40;

A35-B3-C41;

A35-B3-C42;

A35-B3-C43;

A35-B3-C44;

A35-B3-C45;

A35-B3-C46;

A35-B3-C47;

A35-B3-C48;

A35-B3-C49;

A35-B3-C50;

A35-B3-C51;

A35-B3-C52;

A35-B3-C53;

A35-B3-C54;

A35-B3-C55;

A35-B3-C56;

A35-B3-C57;

A35-B3-C58;

A35-B3-C59;

A35-B3-C60;

A35-B3-C61;

A35-B3-C62;

A35-B3-C63;

A35-B3-C64;

A35-B3-C65;

A35-B3-C66;

A35-B3-C67;

A35-B3-C68;

A36-B3-C1;

A36-B3-C2;

A36-B3-C3;

A36-B3-C4;

A36-B3-C5;

A36-B3-C6;

A36-B3-C7;

A36-B3-C8;

A36-B3-C9;

A36-B3-C10;

A36-B3-C11;

A36-B3-C12;

A36-B3-C13;

A36-B3-C14;

A36-B3-C15;

A36-B3-C16;

A36-B3-C17;

A36-B3-C18;

A36-B3-C19;

A36-B3-C20;

A36-B3-C21;

A36-B3-C22;

A36-B3-C23;

A36-B3-C24;

3636-B3-C25;

A36-B3-C26;

A36-B3-C27;

A36-B3-C28;

A36-B3-C29;

A36-B3-C30;

A36-B3-C31;

A36-B3-C32;

A36-B3-C33;

A36-B3-C34;

A36-B3-C35;

A36-B3-C36;

A36-B3-C37;

A36-B3-C38;

A36-B3-C39;

A36-B3-C40;

A36-B3-C41;

A36-B3-C42;

·· · * · · · · · ·

A36-B3-C43; A37-B3-C8; A37-B3-C41; A38-B3-C6; A38-B3-C39; A36-B3-C44; A37-B3-C9; A37-B3-C42; A38-B3-C7; A38-B3-C40; A36-B3-C45; A37-B3-C10; A37-B3-C43; A38-B3-C8; A38-B3-C41; A36-B3-C46; A37-B3-C11; A37-B3-C44; A38-B3-C9; A38-B3-C42; A36-B3-C47; A37-B3-C12; A37-B3-C45; A38-B3-C10; A38-B3-C43; A36-B3-C48; A37-B3-C13; A37-B3-C46; A38-B3-C11; A38-B3-C44; A36-B3-C49; A37-B3-C14; A37-B3-C47; A38-B3-C12; A38-B3-C45; A36-B3-C50; A37-B3-C15; A37-B3-C48; A38-B3-C13; A38-B3-C46; A36-B3-C51; A37-B3-C16; A37-B3-C49; A38-B3-C14; A38-B3-C47; A36-B3-C52; A37-B3-C17; A37-B3-C50; A38-B3-C15; A38-B3-C48; A36-B3-C53; A37-B3-C18; A37-B3-C51; A38-B3-C16; A38-B3-C49; A36-B3-C54; A37-B3-C19; A37-B3-C52; A38-B3-C17; A38-B3-C50; A36-B3-C55; A37-B3-C20; A37-B3-C53; A38-B3-C18; A38-B3-C51; A36-B3-C56; A37-B3-C21; A37-B3-C54; A38-B3-C19; A38-B3-C52; A36-B3-C57; A37-B3-C22; A37-B3-C55; A38-B3-C20; A38-B3-C53; A36-B3-C58; A37-B3-C23; A37-B3-C56; A38-B3-C21; A38-B3-C54; A36-B3-C59; A37-B3-C24; A37-B3-C57; A38-B3-C22; A38-B3-C55; A36-B3-C60; A37-B3-C25; A37-B3-C58; A38-B3-C23; A38-B3-C56; A36-B3-C61; A37-B3-C26; A37-B3-C59; A38-B3-C24; A38-B3-C57; A36-B3-C62; A37-B3-C27; A37-B3-C60; A38-B3-C25; A38-B3-C58; A36-B3-C63; A37-B3-C28; A37-B3-C61; A38-B3-C26; A38-B3-C59; A36-B3-C64; A37-B3-C29; A37-B3-C62; A38-B3-C27; A38-B3-C60; A36-B3-C65; A37-B3-C30; A37-B3-C63; A38-B3-C28; A38-B3-CO1; A36-B3-C66; A37-B3-C31; A37-B3-C64; A38-B3-C29; A38-B3-C62; A36-B3-C67; A37-B3-C32; A37-B3-C65; A38-B3-C30; A38-B3-C63; A36-B3-C68; A37-B3-C33; A37-B3-C66; A38-B3-C31; A38-B3-C64; A37-B3-C1; ( A37-B3-C34; A37-B3-C67; A38-B3-C32; A38-B3-C65; A37-B3-C2; A37-B3-C35; A37-B3-C68; A38-B3-C33; A38-B3-C66; A37-B3-C3; A37-B3-C36; A38-B3-C1; A38-B3-C34; A38-B3-C67; A37-B3-C4; A37-B3-C37; A38-B3-C2; A38-B3-C35; A38-B3-C68; A37-B3-C5; A37-B3-C38; A38-B3-C3; A38-B3-C36; A1-B4-C1; A37-B3-C6; A37-B3-C39; A38-B3-C4; A38-B3-C37; A1-B4-C2; A37-B3-C7; A37-B3-C40; A38-B3-C5; A38-B3-C38; A1-B4-C3;

- 138 -

A1-B4-C4;

A1-B4-C5;

A1-B4-C6;

A1-B4-C7;

A1-B4-C8;

A1-B4-C9;

A1-B4-C10;

A1-B4-C11;

A1-B4-C12;

A1-B4-C13;

A1-B4-C14;

A1-B4-C15;

A1-B4-C16;

A1-B4-C17;

A1-B4-C18;

A1-B4-C19;

A1-B4-C20;

A1-B4-C21;

A1-B4-C22;

A1-B4-C23;

A1-B4-C24;

A1-B4-C25;

A1-B4-C26;

A1-B4-C27;

A1-B4-C28;

A1-B4-C29;

A1-B4-C30;

AND

A1-B4-C31;

A1-B4-C32;

A1-B4-C33;

A1-B4-C34;

A1-B4-C35;

A1-B4-C36;

A1-B4-C37;

A1-B4-C38;

A1-B4-C39;

A1-B4-C40;

A1-B4-C41;

A1-B4-C42;

A1-B4-C43;

A1-B4-C44;

A1-B4-C45;

A1-B4-C46;

A1-B4-C47;

A1-B4-C48;

A1-B4-C49;

A1-B4-C50;

A1-B4-C51;

A1-B4-C52;

A1-B4-C53;

A1-B4-C54;

A1-B4-C55;

A1-B4-C56;

A1-B4-C57;

A1-B4-C58;

A1-B4-C59;

A1-B4-C60;

A1-B4-C61;

A1-B4-C62;

A1-B4-C63;

A1-B4-C64;

Al-B 4 -C 60;

A1-B4-C66;

A1-B4-C67;

A1-B4-C68;

A2-B4-C1;

A2-B4-C2;

A2-B4-C3;

A2-B4-C4;

A2-B4-C5;

A2-B4-C6;

A2-B4-C7;

A2-B4-C8;

A2-B4-C9;

A2-B4-C10;

A2-B4-C11;

A2-B4-C12;

A2-B4-C13;

A2-B4-C14;

A2-B4-C15;

A2-B4-C16;

A2-B4-C17;

A2-B4-C18;

A2-B4-C19;

A2-B4-C20;

A2-B4-C21;

A2-B4-C22;

A2-B4-C23;

A2-B4-C24;

A2-B4-C25;

A2-B4-C26;

A2-B4-C27;

A2-B4-C28;

A2-B4-C29;

A2-B4-C30;

A2-B4-C31;

A2-B4-C32;

A2-B4-C33;

A2-B4-C34;

A2-B4-C35;

A2-B4-C36;

A2-B4-C37;

A2-B4-C38;

A2-B4-C39;

A2-B4-C40;

A2-B4-C41;

A2-B4-C42;

A2-B4-C43;

A2-B4-C44;

A2-B4-C45;

A2-B4-C46;

A2-B4-C47;

A2-B4-C48;

A2-B4-C49;

A2-B4-C50;

A2-B4-C51;

A2-B4-C52;

A2-B4-C53;

A2-B4-C54;

A2-B4-C55;

A2-B4-C56;

A2-B4-C57;

A2-B4-C58;

A2-B4-C59;

A2-B4-C60;

A2-B4-C61;

A2-B4-C62;

A2-B4-C63;

A2-B4-C64;

A2-B4-C65;

A2-B4-C66;

A2-B4-C67;

A2-B4-C68;

A3-B4-C1;

A3-B4-C2;

A3-B4-C3;

A3-B4-C4;

A3-B4-C5;

A3-B4-C6;

A3-B4-C7;

A3-B4-C8;

A3-B4-C9;

A3-B4-C10;

A3-B4-C11;

A3-B4-C12;

A3-B4-C13;

A3-B4-C14;

A3-B4-C15;

A3-B4-C16;

A3-B4-C17;

A3-B4-C18;

A3-B4-C19;

A3-B4-C20;

A3-B4-C21;

A3-B4-C22;

A3-B4-C23;

A3-B4-C24;

A3-B4-C25;

A3-B4-C26;

A3-B4-C27;

A3-B4-C28;

A3-B4-C29;

A3-B4-C30;

A3-B4-C31;

A3-B4-C32;

-139Φ Φ φ Ο Φ · Φ φ φ φ φ φ φ φ φ φ φ φ φ φ

A3-B4-C33;

A3-B4-C34;

A3-B4-C35;

A3-B4-C36;

A3-B4-C37;

A3-B4-C38;

A3-B4-C39;

A3-B4-C40;

A3-B4-C41;

A3-B4-C42;

A3-B4-C43;

A3-B4-C44;

A3-B4-C45;

A3-B4-C46;

A3-B4-C47;

A3-B4-C48;

A3-B4-C49;

A3-B4-CS1;

A3-B4-C51;

A3-B4-C52;

A3-B4-C53;

A3-B4-C54;

A3-B4-C55;

A3-B4-C55;

A3-B4-C57;

A3-B4-C58;

A3-B4-C59;

<

A3-B4-C60;

A3-B4-C61;

A3-B4-C62;

A3-B4-C63;

A3-B4-C64;

A3-B4-C65;

A3-B4-C66;

A3-B4-C67;

A3-B4-C68;

A4-B4-C1;

A4-B4-C2;

A4-B4-C3;

A4-B4-C4;

A4-B4-C5;

A4-B4-C6;

A4-B4-C7;

A4-B4-C8;

A4-B4-C9;

A4-B4-C10;

A4-B4-C11;

A4-B4-C12;

A4-B4-C13;

A4-B4-C14;

A4-B4-C15;

A4-B4-C16;

A4-B4-C17;

A4-B4-C18;

A4-B4-C19;

A4-B4-C20;

A4-B4-C21;

A4-B4-C22;

A4-B4-C23;

A4-B4-C24;

A4-B4-C25;

A4-B4-C26;

A4-B4-C27;

A4-B4-C28;

A4-B4-C29;

A4-B4-C30;

A4-B4-C31;

A4-B4-C32;

A4-B4-C33;

A4-B4-C34;

A4-B4-C35;

A4-B4-C36;

A4-B4-C37;

A4-B4-C38;

A4-B4-C39;

A4-B4-C40;

A4-B4-C41;

A4-B4-C42;

A4-B4-C43;

A4-B4-C44;

A4-B4-C45;

A4-B4-C46;

A4-B4-C47;

A4-B4-C48;

A4-B4-C49;

A4-B4-C50;

A4-B4-C51;

A4-B4-C52;

A4-B4-C53;

A4-B4-C54;

A4-B4-C55;

A4-B4-C55;

A4-B4-C57;

A4-B4-C58;

A4-B4-C59;

A4-B4-C60;

A4-B4-C61;

A4-B4-C62;

A4-B4-C63;

A4-B4-C64;

A4-B4-C65;

A4-B4-C66;

A4-B4-C67;

A4-B4-C68;

A5-B4-C1;

A5-B4-C2;

A5-B4-C3;

A5-B4-C4;

A5-B4-C5;

A5-B 4 -C 6;

A5-B4-C7;

A5-B4-C8;

A5-B4-C9;

A5-B4-C10;

A5-B4-C11;

A5-B4-C12;

A5-B4-C13;

A5-B4-C14;

A5-B4-C15;

A5-B4-C16;

A5-B4-C17;

A5-B4-C18;

A5-B4-C19;

A5-B4-C20;

A5-B4-C21;

A5-B4-C22;

A5-B4-C23;

A5-B4-C24;

A5-B4-C25;

A5-B4-C26;

A5-B4-C27;

A5-B4-C28;

A5-B4-C29;

A5-B4-C30;

A5-B4-C31;

A5-B4-C32;

A5-B4-C33;

A5-B4-C34;

A5-B4-C35;

A5-B4-C36;

A5-B4-C37;

A5-B4-C38;

A5-B4-C39;

A5-B4-C40;

A5-B4-C41;

A5-B4-C42;

A5-B4-C43;

A5-B4-C44;

A5-B4-C45;

A5-B4-C46;

A5-B4-C47;

A5-B4-C48;

A5-B4-C49;

A5-B4-C50;

A5-B4-C51;

A5-B4-C52;

A5-B4-CS3;

A5-B4-C54;

A5-B4-C55;

A5-B4-C56;

A5-B4-C57;

A5-B4-C58;

A5-B4-C59;

A5-B4-C60;

A5-B4-C61;

-140 -

A5-B4-C62;

A5-B4-C63;

A5-B4-C64;

A5-B4-C65;

A5-B4-C66;

A5-B4-C67;

A5-B4-C68;

A6-B4-C1;

A6-B4-C2;

A6-B4-C3;

A6-B4-C4;

A6-B4-C5;

A6-B4-C6;

A6-B4-C7;

A6-B4-C8;

A6-B4-C9;

A6-B4-C10;

A6-B4-C11;

A6-B4-C12;

A6-B4-C13;

A6-B4-C14;

A6-B4-C15;

A6-B4-C16;

A6-B4-C17;

A6-B4-C18;

A6-B4-C19;

A6-B4-C20;

A6-B4-C21;

A6-B4-C22;

A6-B4-C23;

A6-B4-C24;

A6-B4-C25;

A6-B4-C26;

A6-B4-C27;

A6-B4-C28;

A6-B4-C29;

A6-B4-C30;

A6-B4-C31;

A6-B4-C32;

A6-B4-C33;

A6-B4-C34;

A6-B4-C35;

A6-B4-C36;

A6-B4-C37;

A6-B4-C38;

A6-B4-C39;

A6-B4-C40;

A6-B4-C41;

A6-B4-C42;

A6-B4-C43;

A6-B4-C44;

A6-B4-C45;

A6-B4-C46;

A6-B4-C47;

A6-B4-C48;

A6-B4-C49;

A6-B4-C50;

A6-B4-C51;

A6-B4-C52;

A6-B4-C53;

A6-B4-CS4

A6-B4-C55;

A6-B4-C55;

A6-B4-C57;

A6-B4-C58;

A6-B4-C59;

A6-B4-C60;

A6-B4-C61;

A6-B4-C62;

A6-B4-C63;

A6-B4-C64;

A6-B4-C65;

A6-B4-C66;

A6-B4-C67;

A6-B4-C68;

A7-B4-C1;

A7-B4-C2;

A7-B4-C3;

A7-B4-C4;

A7-B4-C5;

A7-B4-C6;

A7-B4-C7;

A7-B4-C8;

A7-B4-C9;

77-B4-C10;

A7-B4-C11;

A7-B4-C12;

A7-B4-C13;

A7-B4-C14;

A7-B4-C15;

A7-B4-C16;

A7-B4-C17;

A7-B4-C18;

A7-B4-C19;

A7-B4-C20;

A7-B4-C21;

A7-B4-C22;

A7-B4-C23;

A7-B4-C24;

A7-B4-C25;

A7-B4-C26;

A7-B4-C27;

A7-B4-C28;

A7-B4-C29;

A7-B4-C30;

A7-B4-C31;

77-B4-C32;

A7-B4-C33;

A7-B4-C34;

77-B4-C35;

77-B4-C36;

A7-B4-C37;

A7-B4-C38;

A7-B4-C39;

77-B4-C40;

A7-B4-C41;

A7-B4-C42;

A7-B4-C43;

A7-B4-C44;

A7-B4-C45;

77-B4-C46;

A7-B4-C47;

77-B4-C48;

77-B4-C49;

A7-B4-C50;

A7-B4-C51;

77-B4-C52;

77-B4-C53;

A7-B4-C54;

A7-B4-C55;

A7-B4-C56;

77-B4-C57;

77-B4-C58;

A7-B4-C59;

A7-B4-C60;

77-B4-C61;

A7-B4-C62;

A7-B4-C63;

77-B4-C64;

77-B4-C65;

A7-B4-C66;

A7-B4-C67;

A7-B4-C68;

A8-B4-C1;

A8-B4-C2;

A8-B4-C3;

A8-B4-C4;

88-B4-C5;

A8-B4-C6;

A8-B4-C7;

A8-B4-C8;

A8-B4-C9;

A8-B4-C10;

A8-B4-C11;

A8-B4-C12;

A8-B4-C13;

A8-B4-C14;

A8-B4-C15;

A8-B4-C16;

A8-B4-C17;

A8-B4-C18;

A8-B4-C19;

A8-B4-C20;

A8-B4-C21;

A8-B4-C22;

- 141 -

A8-B4-C23;

A8-B4-C24;

A8-B4-C25;

A8-B4-C26;

A8-B4-C27;

A8-B4-C28;

A8-B4-C29;

A8-B4-C30;

A8-B4-C31;

A8-B4-C32;

A8-B4-C33;

A8-B4-C34;

88-B4-C35;

A8-B4-C36;

A8-B4-C37;

A8-B4-C38;

A8-B4-C39;

A8-B4-C40;

A8-B4-C41;

A8-B4-C42;

A8-B4-C43;

A8-B4-C44;

A8-B4-C45;

A8-B4-C46;

A8-B4-C47;

A8-B4-C48;

88-B4-C49;

(

A8-B4-C50;

A8-B4-C51;

A8-B4-C52;

A8-B4-C53;

A8-B4-C54;

A8-B4-C55;

A8-B4-C56;

A8-B4-C57;

88-B4-C58;

A8-B4-C59;

A8-B4-C60;

A8-B4-C61;

A8-B4-C62;

A8-B4-C63;

A8-B4-C64;

A8-B4-C65;

A8-B4-C66;

A8-B4-C67;

A8-B4-C68;

A9-B4-C1;

A9-B4-C2;

A9-B4-C3;

99-B4-C4;

A9-B4-C5;

A9-B4-C6;

A9-B4-C7;

A9-B4-C8;

A9-B4-C9;

99-B4-C10;

A9-B4-C11;

99-B4-C12;

A9-B4-C13;

A9-B4-C14;

A9-B4-C15;

99-B4-C16;

A9-B4-C17;

99-B4-C18;

A9-B4-C19;

A9-B4-C20;

A9-B4-C21;

A9-B4-C22;

A9-B4-C23;

A9-B4-C24;

A9-B4-C25;

A9-B4-C26;

A9-B4-C27;

A9-B4-C28;

99-B4-C29;

99-B4-C30;

99-B4-C31;

99-B4-C32;

99-B4-C33;

99-B4-C34;

99-B4-C35;

99-B4-C36;

99-B4-C37;

99-B4-C38;

99-B4-C39;

99-B4-C40;

99-B4-C41;

99-B4-C42;

A9-B4-C43;

99-B4-C44;

99-B4-C45;

99-B4-C46;

99-B4-C47;

99-B4-C48;

99-B4-C49;

99-B4-C50;

99-B4-C51;

99-B4-C52;

99-B4-C53;

99-B4-C54;

99-B4-C55;

99-B4-C56;

99-B4-C57;

99-B4-C58;

99-B4-C59;

99-B4-C60;

99-B4-C61;

A9-B4-C62;

99-B4-C63;

99-B4-C64;

99-B4-C65;

99-B4-C66;

A9-B4-C67;

99-B4-C68;

A10-B4-C1;

A10-B4-C2;

A10-B4-C3;

A10'B4-C4;

A10-B4-C5;

A10-B4-C6;

A10-B4-C7;

A10-B4-C8;

A10-B4-C9;

A10-B4-C10;

A10-B4-C11;

A10-B4-C12;

A10-B4-C13;

A10-B4-C14;

A10-B4-C15;

A10-B4-C16;

A10-B4-C17;

A10-B4-C18;

A10-B4-C19;

A10-B4-C20;

A10-B4-C21;

A10-B4-C22;

A10-B4-C23;

A10-B4-C24;

A10-B4-C25;

A10-B4-C26;

A10-B4-C27;

A10-B4-C28;

A10-B4-C29;

A10-B4-C30;

A10-B4-C31;

A10-B4-C32;

A10-B4-C33;

A10-B4-C34;

A10-B4-C35;

A10-B4-C36;

A10-B4-C37;

A10-B4-C38;

A10-B4-C39;

A10-B4-C40;

A10-B4-C41;

A10-B4-C42;

A10-B4-C43;

A10-B4-C44;

A10-B4-C45;

A10-B4-C46;

A10-B4-C47;

A10-B4-C48;

A10-B4-C49;

A10-B4-C50;

A10-B4-C51;

- 142 · · · · · · 142 142

ΦΦΦ ΦΦΦ ·· •• φ φφ φφ ΦΦΦ φφ ΦΦΦ

A10-B4-C52; A11-B4-C17; A11-B4-C50; A12-B4-C15; A12-B4-C48; A10-B4-C53; A11-B4-C18; A11-B4-C51; A12-B4-C16; A12-B4-C49; A10-B4-C54; A11-B4-C19; AU-B4-C52; A12-B4-C17; A12-B4-C50; A10-B4-C55; A11-B4-C20; A11-B4-C53; A12-B4-C18; A12-B4-CS1; A10-B4-C56; A11-B4-C21; A11-B4-C54; A12-B4-C19; A12-B4-C52; A10-B4-C57; A11-B4-C22; A11-B4-C55; A12-B4-C20; A12-B4-C53; A10-B4-C58; A11-B4-C23; A11-B4-C56; A12-B4-C21; A12-B4-C54; A10-B4-C59; A11-B4-C24; A11-B4-C57; A12-B4-C22; A12-B4-C55; A10-B4-C60; A11-B4-C25; A11-B4-C58; A12-B4-C23; A12-B4-C56; A10-B4-C61; A11-B4-C26; A11-B4-C59; A12-B4-C24; A12-B4-C57; A10-B4-C62; A11-B4-C27; A11-B4-C60; A12-B4-C25; A12-B4-C58; A10-B4-C63; A11-B4-C28; A11-B4-C61; A12-B4-C26; A12-B4-C59; A10-B4-C64; A11-B4-C29; A11-B4-C62; A12-B4-C27; A12-B4-C60; A10-B4-C65; A11-B4-C30; A11-B4-C63; A12-B4-C28; A12-B4-C61; A10-B4-C66; A11-B4-C31; A11-B4-C64; A12-B4-C29; A12-B4-C62; A10-B4-C67; A11-B4-C32; A11-B4-C65; A12-B4-C30; A12-B4-C63; A10-B4-C68; A11-B4-C33; A11-B4-C66; A12-B4-C31; A12-B4-C64; A11-B4-C1; A11-B4-C34; A11-B4-C67; A12-B4-C32; A12-B4-C65; A11-B4-C2; A11-B4-C35; A11-B4-C68; A12-B4-C33; A12-B4-C66; A11-B4-C3; A11-B4-C36; A12-B4-C1; A12-B4-C34; A12-B4-C67; A11-B4-C4; A11-B4-C37; A12-B4-C2; A12-B4-C35; A12-B4-C68; A11-B4-C5; A11-B4-C38; A12-B4-C3; A12-B4-C36; A13-B4-C1; A11-B4-C6; A11-B4-C39; A12-B4-C4; A12-B4-C37; A13-B4-C2; A11-B4-C7; A11-B4-C40; A12-B4-C5; A12-B4-C38; A13-B4-C3; A11-B4-C8; A11-B4-C41; A12-B4-C6; A12-B4-C39; A13-B4-C4; A11-B4-C9; A11-B4-C42; A12-B4-C7; A12-B4-C40; A13-B4-C5; All-B4rC10; A11-B4-C43; A12-B4-C8; A12-B4-C41; A13-B4-C6; A11-B4-C11; A11-B4-C44; A12-B4-C9; A12-B4-C42; A13-B4-C7; A11-B4-C12; A11-B4-C45; A12-B4-C10; A12-B4-C43; A13-B4-C8; A11-B4-C13; A11-B4-C46; A12-B4-C11; A12-B4-C44; A13-B4-C9; A11-B4-C14; A11-B4-C47; A12-B4-C12; A12-B4-C45; A13-B4-C10; A11-B4-C15; A11-B4-C48; A12-B4-C13; A12-B4-C46; A13-B4-C11; A11-B4-C16; A11-B4-C49; A12-B4-C14; A12-B4-C47; A13-B4-C12;

-143A13-B4-C13;

A13-B4-C14;

A13-B4-C15;

A13-B4-C16;

A13-B4-C17;

A13-B4-C18;

A13-B4-C19;

A13-B4-C20;

A13-B4-C21;

A13-B4-C22;

A13-B4-C23;

A13-B4-C24;

A13-B4-C25;

A13-B4-C26;

A13-B4-C27;

A13-B4-C28;

A13-B4-C29;

A13-B4-C30;

A13-B4-C31;

A13-B4-C32;

A13-B4-C33;

A13-B4-C34;

A13-B4-C35;

A13-B4-C36;

A13-B4-C37;

A13-B4-C38;

A13-B4-C39;

AND

A13-B4-C40;

A13-B4-C41;

A13-B4-C42;

A13-B4-C43;

A13-B4-C44;

A13-B4-C45;

A13-B4-C46;

A13-B4-C47;

A13-B4-C48;

A13-B4-C49;

A13-B4-C50;

A13-B4-C51;

A13-B4-C52;

A13-B4-C53;

A13-B4-C54;

A13-B4-C55;

A13-B4-C56;

A13-B4-C57;

A13-B4-C58;

A13-B4-C59;

A13-B4-C60;

A13-B4-C61;

A13-B4-C62;

A13-B4-C63;

A13-B4-C64;

A13-B4-C65;

A13-B4-C66;

A13-B4-C67;

A13-B4-C68;

A14-B4-C1;

A14-B4-C2;

A14-B4-C3;

A14-B4-C4;

A14-B4-C5;

A14-B4-C6;

A14-B4-C7;

A14-B4-C8;

A14-B4-C9;

A14-B4-C10;

A14-B4-C11;

A14-B4-C12;

A14-B4-C13;

A14-B4-C14;

A14-B4-C15;

A14-B4-C16;

A14-B4-C17;

A14-B4-C18;

A14-B4-C19;

A14-B4-C20;

A14-B4-C21;

A14-B4-C22;

A14-B4-C23;

A14-B4-C24;

A14-B4-C25;

A14-B4-C26;

A14-B4-C27;

A14-B4-C28;

A14-B4-C29;

A14-B4-C30;

A14-B4-C31;

A14-B4-C32;

A14-B4-C33;

A14-B4-C34;

A14-B4-C35;

A14-B4-C36;

A14-B4-C37;

A14-B4-C38;

A14-B4-C39;

A14-B4-C40;

A14-B4-C41;

A14-B4-C42;

A14-B4-C43;

A14-B4-C44;

A14-B4-C45;

A14-B4-C46;

A14-B4-C47;

A14-B4-C48;

A14-B4-C49;

A14-B4-C50;

A14-B4-C51;

A14-B4-C52;

A14-B4-C53;

A14-B4-C54;

A14-B4-C55;

A14-B4-C56;

A14-B4-C57;

A14-B4-C58;

A14-B4-C59;

A14-B4-C60;

A14-B4-C61;

A14-B4-CO2;

A14-B4-C63;

A14-B4-C64;

A14-B4-C65;

A14-B4-C66;

A14-B4-C67;

A14-B4-C68;

A15-B4-C1;

A15-B4-C2;

A15-B4-C3;

A15-B4-C4;

A15-B4-C5;

A15-B4-C6;

A15-B4-C7;

A15-B4-C8;

A15-B4-C9;

A15-B4-C10;

A15-B4-C11;

A15-B4-C12;

A15-B4-C13;

A15-B4-C14;

A15-B4-C15;

A15-B4-C16;

A15-B4-C17;

A15-B4-C18;

A15-B4-C19;

A15-B4-C20;

A15-B4-C21;

A15-B4-C22;

A15-B4-C23;

A15-B4-C24;

A15-B4-C25;

A15-B4-C26;

A15-B4-C27;

A15-B4-C28;

A15-B4-C29;

A15-B4-C30;

A15-B4-C31;

A15-B4-C32;

A15-B4-C33;

A15-B4-C34;

A15-B4-C35;

A15-B4-C36;

A15-B4-C37;

A15-B4-C38;

A15-B4-C39;

A15-B4-C40;

A15-B4-C41;

-144 • 99 99 9 ♦ · 9 9 9 9 ·· • 99 9 · 9 · · 99 99 999 99

A15-B4-C42;

A15-B4-C43;

A15-B4-C44;

A15-B4-C45;

A15-B4-C46;

A15-B4-C47;

A15-B4-C48;

A15-B4-C49;

A15-B4-C50;

A15-B4-C51;

A15-B4-C52;

A15-B4-C53;

A15-B4-C54;

A15-B4-C55;

A15-B4-C56;

A15-B4-C57;

A15-B4-C58;

A15-B4-C59;

A15-B4-C60;

A15-B4-C61;

A15-B4-C62;

A15-B4-C63;

A15-B4-C64;

A15-B4-C65;

A15-B4-C66;

A15-B4-C67;

A15-B4-C68;

AND

A16-B4-C1;

A16-B4-C2;

A16-B4-C3;

A16-B4-C4;

Al6-B4-C5;

A16-B4-C6;

A16-B4-C7;

A16-B4-C8;

A16-B4-C9;

A16-B4-C10;

A16-B4-C11;

A16-B4-C12;

A16-B4-C13;

A16-B4-C14;

A16-B4-C15;

A16-B4-C16;

A16-B4-C17;

A16-B4-C18;

A16-B4-C19;

A16-B4-C20;

A16-B4-C21;

A16-B4-C22;

A16-B4-C23;

A16-B4-C24;

A16-B4-C25;

A16-B4-C26;

A16-B4-C27;

A16-B4-C28;

A16-B4-C29;

A16-B4-C30;

A16-B4-C31;

A16-B4-C32;

A16-B4-C33;

A16-B4-C34;

A16-B4-C35;

A16-B4-C36;

A16-B4-C37;

A16-B4-C38;

A16-B4-C39;

A16-B4-C40;

A16-B4-C41;

A16-B4-C42;

A16-B4-C43;

A16-B4-C44;

A16-B4-C45;

A16-B4-C46;

A16-B4-C47;

A16-B4-C48;

A16-B4-C49;

A16-B4-C50;

A16-B4-C51;

A16-B4-C52;

A16-B4-C53;

A16-B4-C54;

A16-B4-C55;

A16-B4-C56;

A16-B4-C57;

A16-B4-C58;

A16-B4-C59;

A16-B4-C60;

A16-B4-C61;

A16-B4-C62;

A16-B4-C63;

A16-B4-C64;

A16-B4-C65;

A16-B4-C66;

A16-B4-C67;

A16-B4-C68;

A17-B4-C1;

A17-B4-C2;

A17-B4-C3;

A17-B4-C4;

Al7-B4-C5;

A17-B4-C6;

A17-B4-C7;

A17-B4-C8;

A17-B4-C9;

A17-B4-C10;

A17-B4-C11;

A17-B4-C12;

A17-B4-C13;

A17-B4-C14;

A17-B4-C15;

A17-B4-C16;

A17-B4-C17;

A17-B4-C18;

A17-B4-C19;

A17-B4-C20;

A17-B4-C21;

A17-B4-C22;

A17-B4-C23;

A17-B4-C24;

A17-B4-C25;

A17-B4-C26;

A17-B4-C27;

A17-B4-C28;

A17-B4-C29;

A17-B4-C30;

A17-B4-C31;

A17-B4-C32;

A17-B4-C33;

A17-B4-C34;

A17-B4-C35;

A17-B4-C36;

A17-B4-C37;

A17-B4-C38;

A17-B4-C39;

A17-B4-C40;

A17-B4-C41;

A17-B4-C42;

A17-B4-C43;

A17-B4-C44;

A17-B4-C45;

A17-B4-C46;

A17-B4-C47;

A17-B4-C48;

A17-B4-C49;

A17-B4-C50;

A17-B4-C51;

A17-B4-C52;

A17-B4-C53;

A17-B4-C54;

A17-B4-C55;

A17-B4-C56;

A17-B4-C57;

A17-B4-C58;

A17-B4-C59;

A17-B4-C60;

A17-B4-C61;

A17-B4-C62;

A17-B4-C63;

A17-B4-C64;

A17-B4-C65;

A17-B4-C66;

A17-B4-C67;

A17-B4-C68;

A18-B4-C1;

A18-B4-C2;

• · · · · · · · · · · · · · · · · · · · · · ·

-145 ··· ·· ·· ··· ·· ···

A18-B4-C3;

A18-B4-C4;

A18-B4-C5;

A18-B4-C6;

A18-B4-C7;

A18-B4-C8;

A18-B4-C9;

A18-B4-C10;

A18-B4-C11;

A18-B4-C12;

A18-B4-C13;

A18-B4-C14;

A18-B4-C15;

A18-B4-C16;

A18-B4-C17;

A18-B4-C18;

A18-B4-C19;

A18-B4-C20;

A18-B4-C21;

A18-B4-C22;

A18-B4-C23;

A18-B4-C24;

A18B4-C25;

A18-B4-C26;

A18-B4-C27;

A18-B4-C28;

A18-B4-C29;

A18-B4-C30;

A18-B4-C31;

A18-B4-C32;

A18-B4-C33;

A18-B4-C34;

A18-B4-C35;

A18-B4-C36;

A18-B4-C37;

A18-B4-C38;

A18-B4-C39;

A18-B4-C40;

A18-B4-C41;

A18-B4-C42;

A18-B4-C43;

A18-B4-C44;

A18-B4-C45;

A18-B4-C46;

A18-B4-C47;

A18-B4-C48;

A18-B4-C49;

A18-B4-C50;

A18-B4-C51;

A18-B4-C52;

A18-B4-C53;

A18-B4-C54;

A18-B4-C55;

A18-B4-C50;

A18-B4-C57;

A18-B4-C58;

A18-B4-C59;

A18-B4-C60;

A18-B4-C61;

A18-B4-C62;

A18-B4-C63;

A18-B4-C64;

A18-B4-C65;

A18-B4-C66;

A18-B4-C67;

A18-B4-C68;

A19-B4-C1;

A19-B4-C2;

A19-B4-C3;

A19-B4-C4;

A19-B4-C5;

A19-B4-C6;

A19-B4-C7;

A19-B4-C8;

A19-B4-C9;

A19-B4-C10;

A19-B4-C11;

A19-B4-C12;

A19-B4-C13;

A19-B4-C14;

A19-B4-C15;

A19-B4-C16;

A19-B4-C17;

A19-B4-C18;

A19-B4-C19;

A19-B4-C20;

A19-B4-C21;

A19-B4-C22;

A19-B4-C23;

A19-B4-C24;

A19-B4-C25;

A19-B4-C26;

A19-B4-C27;

A19-B4-C28;

A19-B4-C29;

A19-B4-C30;

A19-B4-C31;

A19-B4-C32;

A19-B4-C33;

A19-B4-C34;

A19-B4-C35;

A19-B4-C36;

A19-B4-C37;

A19-B4-C38;

A19-B4-C39;

A19-B4-C40;

A19-B4-C41;

A19-B4-C42;

A19-B4-C43;

A19-B4-C44;

A19-B4-C45;

A19-B4-C46;

A19-B4-C47;

A19-B4-C48;

A19-B4-C49;

A19-B4-C50;

A19-B4-C51;

A19-B4-C52;

A19-B4-C53;

A19-B4-C54;

A19-B4-C55;

A19-B4-C56;

A19-B4-C57;

A19-B4-C58;

A19-B4-C59;

A19-B4-C60;

A19-B4-C61;

A19-B4-C62;

A19-B4-C63;

A19-B4-C64;

A19-B4-C65;

A19-B4-C6O;

A19-B4-C67;

A19-B4-C68;

A20-B4-C1;

A20-B4-C2;

A20-B4-C3;

A20-B4-C4;

A20-B4-C5;

A20-B4-C6;

A20-B4-C7;

A2G-B4-C8;

A20-B4-C9;

A20-B4-C10;

A20-B4-C11;

A20-B4-C12;

A20-B4-C13;

A20-B4-C14;

A20-B4-C15;

A20-B4-C16;

A20-B4-C17;

A20-B4-C18;

A20-B4-C19;

A20-B4-C20;

A20-B4-C21;

A20-B4-C22;

A20-B4-C23;

A20-B4-C24;

A20-B4-C25;

A20-B4-C26;

A20-B4-C27;

A20-B4-C28;

A20-B4-C29;

A20-B4-C30;

A20-B4-C31;

A20-B4-C32;

A20-B4-C33;

A20-B4-C34;

A20-B4-C35;

A20-B4-C36;

A20-B4-C37;

A20-B4-C38;

A20-B4-C39;

A20-B4-C40;

A20-B4-C41;

A20-B4-C42;

A20-B4-C43;

A20-B4-C44;

A20-B4-C45;

A20-B4-C46;

A20-B4-C47;

A20-B4-C48;

A20-B4-C49;

A20-B4-C50;

A20-B4-C51;

A20-B4-C52;

A20-B4-C53;

A20-B4-C54;

A20-B4-C55;

A20-B4-C56;

A20-B4-C57;

A20-B4-C58;

A20-B4-C59;

A20-B4-C60;

A20-B4-C61;

A20-B4-C62;

A20-B4-C63;

A20-B4-C64;

A20-B4-C65; A21-B4-C30; A21-B4-C63; A20-B4-C66; A21-B4-C31; A21-B4-C64; A20-B4-C67; A21-B4-C32; A21-B4-C65; A20-B4-C68; A21-B4-C33; A21-B4-C66; A21-B4-C1; A21-B4-C34; A21-B4-C67; A21-B4-C2; A21-B4-C35; A21-B4-C68; A21-B4-C3; A21-B4-C36; A22-B4-C1; A21-B4-C4; A21-B4-C37; A22-B4-C2; A21-B4-C5; A21-B4-C38; A22-B4-C3; A21-B4-C6; A21-B4-C39; A22-B4-C4; A21-B4-C7; A21-B4-C40; A22-B4-C5; A21-B4-C8; A21-B4-C41; A22-B4-C6; A21-B4-C9; A21-B4-C42; A22-B4-C7; A21-B4-C10; A21-B4-C43; A22-B4-C8; A21-B4-C11; A21-B4-C44; A22-B4-C9; A21-B4-C12; A21-B4-C45; A22-B4-C10; A21-B4-C13; A21-B4-C46; A22-B4-C11; A21-B4-C14; A21-B4-C47; A22-B4-C12; A21-B4-C15; A21-B4-C48; A22-B4-C13; A21-B4-C16; A21-B4-C49; A22-B4-C14; A21-B4-C17; A21-B4-C50; A22-B4-C15; A21-B4-C18; A21-B4-C51; A22-B4-C16; A21-B4-C19; A21-B4-C52; A22-B4-C17; A21-B4-C20; A21-B4-C53; A22-B4-C18; A21-B4-C21; A21-B4-C54; A22-B4-C19; A21-B4-C22; A21-B4-C55; A22-B4-C20; A21-B4-C23; A21-B4-C56; A22-B4-C21; A21-B4-C24; A21-B4-C57; A22-B4-C22; A21-B4-C25; A21-B4-C58; A22-B4-C23; A2I-B4-C26; A21-B4-C59; A22-B4-C24; A21-B4-C27; A21-B4-C60; A22-B4-C25; A21-B4-C28; A21-B4-C61; A22-B4-C26; A21-B4-C29; A21-B4-C62; A22-B4-C27;

A22-B4-C28;

A22-B4-C29;

A22-B4-C30;

A22-B4-C31;

A22-B4-C32;

A22-B4-C33;

A22-B4-C34;

A22-B4-C35;

A22-B4-C36;

A22-B4-C37;

A22-B4-C38;

A22-B4-C39;

A22-B4-C40;

A22-B4-C41;

A22-B4-C42;

A22-B4-C43;

A22-B4-C44;

A22-B4-C45;

A22-B4-C46;

A22-B4-C47;

A22-B4-C48;

A22-B4-C49;

A22-B4-C50;

A22-B4-C51;

A22-B4-C52;

A22-B4-C53;

A22-B4-C54;

A22-B4-C55;

A22-B4-C56;

A22-B4-C57;

A22-B4-C58;

A22-B4-C59;

A22-B4-C60;

- 147-

A22-B4-C61; A23-B4-C26; A23-B4-C59; A24-B4-C24; A24-B4-C57; A22-B4-C62; A23-B4-C27; A23-B4-C60; A24-B4-C25; A24-B4-C58; A22-B4-C63; A23-B4-C28; A23-B4-C61; A24-B4-C26; A24-B4-C59; A22-B4-C64; A23-B4-C29; A23-B4-C62; A24-B4-C27; A24-B4-C60; A22-B4-C65; A23-B4-C30; A23-B4-C63; A24-B4-C28; A24-B4-C61; A22-B4-C66; A23-B4-C31; A23-B4-C64; A24-B4-C29; A24-B4-C62; A22-B4-C67; A23-B4-C32; A23-B4-C65; A24-B4-C30; A24-B4-C63; A22-B4-C68; A23-B4-C33; A23-B4-C66; A24-B4-C31; A24-B4-C64; A23-B4-C1; A23-B4-C34; A23-B4-C67; A24-B4-C32; A24-B4-C65; A23-B4-C2; A23-B4-C35; A23-B4-C68; A24-B4-C33; A24-B4-C66; A23-B4-C3; A23-B4-C36; A24-B4-C1; A24-B4-C34; A24-B4-C67; A23-B4-C4; A23-B4-C37; A24-B4-C2; A24-B4-C35; A24-B4-C68; A23-B4-C5; A23-B4-C38; A24-B4-C3; A24-B4-C36; A25-B4-C1; A23-B4-C6; A23-B4-C39; A24-B4-C4; A24-B4-C37; A25-B4-C2; A23-B4-C7; A23-B4-C40; A24-B4-C5; A24-B4-C38; A25-B4-C3; A23-B4-C8; A23-B4-C41; A24-B4-C6; A24-B4-C39; A25-B4-C4; A23-B4-C9; A23-B4-C42; A24-B4-C7; A24-B4-C40; A25-B4-C5; A23-B4-C10; A23-B4-C43; A24-B4-C8; A24-B4-C41; A25-B4-C6; A23-B4-C11; A23-B4-C44; A24-B4-C9; A24-B4-C42; A25-B4-C7; A23-B4-C12; A23-B4-C45; A24-B4-C10; A24-B4-C43; A25-B4-C8; A23-B4-C13; A23-B4-C46; A24-B4-C11; A24-B4-C44; A25-B4-C9; A23-B4-C14; A23-B4-C47; A24-B4-C12; A24-B4-C45; A25-B4-C10; A23-B4-C15; A23-B4-C48; A24-B4-C13; A24-B4-C46; A25-B4-C11; A23-B4-C16; A23-B4-C49; A24-B4-C14; A24-B4-C47; A25-B4-C12; A23-B4-C17; A23-B4-C50; A24-B4-C15; A24-B4-C48; A25-B4-C13; A23-B4-C18; A23-B4-C51; A24-B4-C16; A24-B4-C49; A25-B4-C14; A23-B4-C19; A23-B4-C52; A24-B4-C17; A24-B4-C50; A25-B4-C15; A23-B4-C20; A23-B4-C53; A24-B4-C18; A24-B4-C51; A25-B4-C16; A23-B4-C21; A23-B4-C54; A24-B4-C19; A24-B4-C52; A25-B4-C17; A23-B4-C22; A23-B4-C55; A24-B4-C20; A24-B4-C53; A25-B4-C18; A23-B4-C23; A23-B4-C56; A24-B4-C21; A24-B4-C54; A25-B4-C19; A23-B4-C24; A23-B4-C57; A24-B4-C22; A24-B4-C55; A25-B4-C20; A23-B4-C25; A23-B4-C58; A24-B4-C23; A24-B4-C56; A25-B4-C21;

- 148 -

A25-B4-C22;

A25-B4-C23;

A25-B4-C24;

A25-B4-C25;

A25-B4-C26;

A25-B4-C27;

A25-B4-C28;

A25-B4-C29;

A25-B4-C30;

A25-B4-C31;

A25-B4-C32;

A25-B4-C33;

A25-B4-C34;

A25-B4-C35;

A25-B4-C36;

A25-B4-C37;

A25-B4-C38;

A25-B4-C39;

A25-B4-C40;

A25-B4-C41;

A25-B4-C42;

A25-B4-C43;

A25-B4-C44;

A25-B4-C45;

A25-B4-C46;

A25-B4-C47;

A25-B4-C48;

(

A25-B4-C49;

A25-B4-C50;

A25-B4-C51;

A25-B4-C52;

A25-B4-C53;

A25-B4-C54;

A25-B4-C55;

A2S-B4-CS6;

A25-B4-C57;

A25-B4-C58;

A25-B4-C59;

A25-B4-C60;

A25-B4-C61;

A25-B4-C62;

A25-B4-C63;

A25-B4-C64;

A25-B4-C65;

A25-B4-C66;

A25-B4-C67;

A25-B4-C68;

A26-B4-C1;

A26-B4-C2;

A26-B4-C3;

A26-B4-C4;

A26-B4-C5;

A26-B4-C6;

A26-B4-C7;

A26-B4-C8;

A26-B4-C9;

A26-B4-C10;

A26-B4-C11;

A26-B4-C12;

A26-B4-C13;

A26-B4-C14;

A26-B4-C15;

A26-B4-C16;

A26-B4-C17;

A26-B4-C18;

A26-B4-C19;

A26-B4-C20;

A26-B4-C21;

A26-B4-C22;

A26-B4-C23;

A26-B4-C24;

A26-B4-C25;

A26-B4-C26;

A26-B4-C27;

A26-B4-C28;

A26-B4-C29;

A26-B4-C30;

A26-B4-C31;

A26-B4-C32;

A26-B4-C33;

A26-B4-C34;

A26-B4-C35;

A26-B4-C36;

A26-B4-C37;

A26-B4-C38;

A26-B4-C39;

A26-B4-C40;

A26-B4-C41;

A26-B4-C42;

A26-B4-C43;

A26-B4-C44;

A26-B4-C45;

A26-B4-C46;

A26-B4-C47;

A26-B4-C48;

A26-B4-C49;

A26-B4-C50;

A26-B4-C51;

A26-B4-C52;

A26-B4-C53;

A26-B4-C54;

A26-B4-C55;

A26-B4-C56;

A26-B4-C57;

A26-B4-C58;

A26-B4-C59;

A26-B4-C60;

A26-B4-C61;

A26-B4-C62;

A26-B4-C63;

A26-B4-C64;

A26-B4-C65;

A26-B4-C66;

A26-B4-C67;

A26-B4-C68;

A27-B4-C1;

A27-B4-C2;

A27-B4-C3;

A27-B4-C4;

A27-B4-C5;

A27-B4-C6;

A27-B4-C7;

A27-B4-C8;

A27-B4-C9;

A27-B4-C10;

A27-B4-C11;

A27-B4-C12;

A27-B4-C13;

A27-B4-C14;

A27-B4-C15;

A27-B4-C16;

A27-B4-C17;

A27-B4-C18;

A27-B4-C19;

A27-B4-C20;

A27-B4-C21;

A27-B4-C22;

A27-B4-C23;

A27-B4-C24;

A27-B4-C25;

A27-B4-C26;

A27-B4-C27;

A27-B4-C28;

A27-B4-C29;

A27-B4-C30;

A27-B4-C31;

A27-B4-C32;

A27-B4-C33;

A27-B4-C34;

A27-B4-C35;

A27-B4-C36;

A27-B4-C37;

A27-B4-C38;

A27-B4-C39;

A27-B4-C40;

A27-B4-C41;

A27-B4-C42;

A27-B4-C43;

A27-B4-C44;

A27-B4-C45;

A27-B4-C46;

A27-B4-C47;

A27-B4-C48;

A27-B4-C49;

A27-B4-C50;

- 149 • φ φ • · · · «· · · · · φ φ φ φ

A27-B4-C51;

A27-B4-C52;

A27-B4-C53;

A27-B4-C54;

A27-B4-C55;

A27-B4-C56;

A27-B4-C57;

A27-B4-C58;

A27-B4-C59;

A27-B4-C60;

A27-B4-C61;

A27-B4-C62;

A27-B4-C63;

A27-B4-C64;

A27-B4-C65;

A27-B4-C66;

A27-B4-C67;

A27-B4-C68;

A28-B4-C1;

A28-B4-C2;

A28-B4-C3;

A28-B4-C4;

A28-B4-C5;

A28-B4-C6;

A28-B4-C7;

A28-B4-C8;

A28-B4-C9;

A28-B4-C10;

A28-B4-C11;

A28-B4-C12;

A28-B4-C13;

A28-B4-C14;

A28-B4-CIS;

A28-B4-C16;

A28-B4-C17;

A28-B4-C18;

A28-B4-C19;

A28-B4-C20;

A28-B4-C21;

A28-B4-C22;

A28-B4-C23;

A28-B4-C24;

A28-B4-C25;

A28-B4-C26;

A28-B4-C27;

A28-B4-C28;

A28-B4-C29;

A28-B4-C30;

A28-B4-C31;

A28-B4-C32;

A28-B4-C33;

A28-B4-C34;

A28-B4-C35;

A28-B4-C36;

A28-B4-C37;

A28-B4-C38;

A28-B4-C39;

A28-B4-C40;

A28-B4-C41;

A28-B4-C42;

A28-B4-C43;

A28-B4-C44;

A28-B4-C45;

A28-B4-C46;

A28-B4-C47;

A28-B4-C48;

A28-B4-C49;

A28-B4-C50;

A28-B4-C51;

A28-B4-C52;

A28-B4-C53;

A28-B4-C54;

A28-B4-C55;

A28-B4-C56;

A28-B4-C57;

A28-B4-C58;

A28-B4-C59;

A28-B4-C60;

A28-B4-C61;

A28-B4-C62;

A28-B4-C63;

A28-B4-C64;

A28-B4-C65;

A28-B4-C66;

A28-B4-C67;

A28-B4-C68;

A29-B4-C1;

A29-B4-C2;

A29-B4-C3;

A29-B4-C4;

A29-B4-C5;

A29-B4-C6;

A29-B4-C7;

A29-B4-C8;

A29-B4-C9;

A29-B4-C10;

A29-B4-C11;

A29-B4-C12;

A29-B4-C13;

A29-B4-C14;

A29-B4-C15;

A29-B4-C16;

A29-B4-C17;

A29-B4-C18;

A29-B4-C19;

A29-B4-C20;

A29-B4-C21;

A29-B4-C22;

A29-B4-C23;

A29-B4-C24;

A29-B4-C25;

A29-B4-C26;

A29-B4-C27;

A29-B4-C28;

A29-B4-C29;

A29-B4-C30;

A29-B4-C31;

A29-B4-C32;

A29-B4-C33;

A29-B4-C34;

A29-B4-C35;

A29-B4-C36;

A29-B4-C37;

A29-B4-C38;

A29-B4-C39;

A29-B4-C40;

A29-B4-C41;

A29-B4-C42;

A29-B4-C43;

A29-B4-C44;

A29-B4-C45;

A29-B4-C46;

A29-B4-C47;

A29-B4-C48;

A29-B4-C49;

A29-B4-C50;

A29-B4-C51;

A29-B4-C52;

A29-B4-C53;

A29-B4-C54;

A29-B4-C55;

A29-B4-C56;

A29-B4-C57;

A29-B4-C58;

A29-B4-C59;

A29-B4-C60;

A29-B4-C61;

A29-B4-C62;

A29-B4-C63;

A29-B4-C64;

A29-B4-C65;

A29-B4-C66;

A29-B4-C67;

A29-B4-C68;

A30-B4-C1;

A30-B4-C2;

A30-B4-C3;

A30-B4-C4;

A30-B4-C5;

A30-B4-C6;

A30-B4-C7;

A30-B4-C8;

A30-B4-C9;

A30-B4-C10;

A30-B4-C11;

A30-B4-C12;

A30-B4-C13;

A30-B4-C14;

A30-B4-C15;

A30-B4-C16;

A30-B4-C17;

A30-B4-C18;

A30-B4-C19;

A30-B4-C20;

A30-B4-C21;

A30-B4-C22;

A30-B4-C23;

A30-B4-C24;

A30-B4-C25;

A30-B4-C26;

A30-B4-C27;

A30-B4-C28;

A30-B4-C29;

A30-B4-C30;

A30-B4-C31;

A30-B4-C32;

A30-B4-C33;

A30-B4-C34;

A30-B4-C35;

A30-B4-C36;

A30-B4-C37;

A30-B4-C38;

A30-B4-C39;

A30-B4-C40;

A30-B4-C41;

A30-B4-C42;

A30-B4-C43;

A30-B4-C44;

♦ ·· ·· · • ·· -150- ::: Υ · · ·· ·· · ·· φ «·· ·» φφφ · · • · · · · · · ·· φφφ ΦΦ • • · • • • φφφ A30-B4-C45; A31-B4-C10; A31-B4-C43; A32-B4-C8; A30-B4-C46; A31-B4-C11; A31-B4-C44; A32-B4-C9; A30-B4-C47; A31-B4-C12; A31-B4-C45; A32-B4-C10; A30-B4-C48; A31-B4-C13; A31-B4-C46; A32-B4-C11; A30-B4-C49; A31-B4-C14; A31-B4-C47; A32-B4-C12; A30-B4-C50; A31-B4-C15; A31-B4-C48; A32-B4-C13; A30-B4-C51; A31-B4-C16; A31-B4-C49; A32-B4-C14; A30-B4-C52; A31-B4-C17; A31-B4-C50; A32-B4-C15; A30-B4-C53; A31-B4-C18; A31-B4-C51; A32-B4-C16; A30-B4-C54; A31-B4-C19; A31-B4-C52; A32-B4-C17; A30-B4-C55; A31-B4-C20; A31-B4-C53; A32-B4-C18; A30-B4-C56; A31-B4-C21; A31-B4-C54; A32-B4-C19; A30-B4-C57; A31-B4-C22; A31-B4-C55; A32-B4-C20; A30-B4-C58; A31-B4-C23; A31-B4-C56; A32-B4-C21; A30-B4-C59; A31-B4-C24; A31-B4-C57; A32-B4-C22; A30-B4-C60; A31-B4-C25; A31-B4-C58; A32-B4-C23; A30-B4-C61; A31-B4-C26; A31-B4-C59; A32-B4-C24; A30-B4-C62; A31-B4-C27; A31-B4-C60; A32-B4-C25; A30-B4-C63; A31-B4-C28; A31-B4-C61; A32-B4-C26; A30-B4-C64; A31-B4-C29; A31-B4-C62; A32-B4-C27; A30-B4-C65; A31-B4-C30; A31-B4-C63; A32-B4-C28; A30-B4-C66; A31-B4-C31; A31-B4-C64; A32-B4-C29; A30-B4-C67; A31-B4-C32; A31-B4-C65; A32-B4-C30; A30-B4-C68; A31-B4-C33; A31-B4-C66; A32-B4-C31; A31-B4-C1; A31-B4-C34; A31-B4-C67; A32-B4-C32; A31-B4-C2; A31-B4-C35; A31-B4-C68; A32-B4-C33; A31-B4-C3; A31-B4-C36; A32-B4-C1; A32-B4-C34; A31-B4-C4; A31-B4-C37; A32-B4-C2; A32-B4-C35; A31-B4-C5; A31-B4-C38; A32-B4-C3; A32-B4-C36; A31-B4-C6; A31-B4-C39; A32-B4-C4; A32-B4-C37; A31-B4-C7; A31-B4-C40; A32-B4-C5; A32-B4-C38; A3I-B4-C8; A31-B4-C41; A32-B4-C6; A32-B4-C39; A31-B4-C9; A31-B4-C42; A32-B4-C7; A32-B4-C40;

- 150 -

151 A32-B4-C41;

A32-B4-C42;

A32-B4-C43;

A32-B4-C44;

A32-B4-C45;

A32-B4-C46;

A32-B4-C47;

A32-B4-C48;

A32-B4-C49;

A32-B4-C50;

A32-B4-C51;

A32-B4-C52;

A32-B4-C53;

A32-B4-C54;

A32-B4-C55;

A32-B4-C56;

A32-B4-C57;

A32-B4-C58;

A32-B4-C59;

A32-B4-C60;

A32-B4-C61;

A32-B4-C62;

A32-B4-C63;

A32-B4-C64;

A32-B4-C65;

A32-B4-C66;

A32-B4-C67;

AND

A32-B4-C68;

A33-B4-C1;

A33-B4-C2;

A33-B4-C3;

A33-B4-C4;

A33-B4-C5;

A33-B4-C6;

A33-B4-C7;

A33-B4-C8;

A33-B4-C9;

A33-B4-C10;

A33-B4-C11;

A33-B4-C12;

A33-B4-C13;

A33-B4-C14;

A33-B4-C15;

A33-B4-C16;

A33-B4-C17;

A33-B4-C18;

A33-B4-C19;

A33-B4-C20;

A33-B4-C21;

A33-B4-C22;

A33-B4-C23;

A33-B4-C24;

A33-B4-C25;

A33-B4-C26;

A33-B4-C27;

A33-B4-C28;

A33-B4-C29;

A33-B4-C30;

A33-B4-C31;

A33-B4-C32;

A33-B4-C33;

A33-B4-C34;

A33-B4-C35;

A33-B4-C36;

A33-B4-C37;

A33-B4-C38;

A33-B4-C39;

A33-B4-C40;

A33-B4-C41;

A33-B4-C42;

A33-B4-C43;

A33-B4-C44;

A33-B4-C45;

A33-B4-C46;

A33-B4-C47;

A33-B4-C48;

A33-B4-C49;

A33-B4-C50;

A33-B4-C51;

A33-B4-C52;

A33-B4-C53;

A33-B4-C54;

A33-B4-C55;

A33-B4-C56;

A33-B4-C57;

A33-B4-C58;

A33-B4-C59;

A33-B4-C60;

A33-B4-C61;

A33-B4-C62;

A33-B4-C63;

A33-B4-C64;

A33-B4-C65;

A33-B4-C66;

A33-B4-C67;

A33-B4-C68;

A34-B4-C1;

A34-B4-C2;

A34-B4-C3;

A34-B4-C4;

A34-B4-C5;

A34-B4-C6;

A34-B4-C7;

A34-B4-C8;

A34-B4-C9;

A34-B4-C10;

A34-B4-C11;

A34-B4-Cl2;

A34-B4-C13;

A34-B4-C14;

A34-B4-C15;

A34-B4-C16;

A34-B4-C17;

A34-B4-C18;

A34-B4-C19;

A34-B4-C20;

A34-B4-C21;

A34-B4-C22;

A34-B4-C23;

A34-B4-C24;

A34-B4-C25;

A34-B4-C26;

A34-B4-C27;

A34-B4-C28;

A34-B4-C29;

A34-B4-C30;

A34-B4-C31;

A34-B4-C32;

A34-B4-C33;

A34-B4-C34;

A34-B4-C35;

A34-B4-C36;

A34-B4-C37;

A34-B4-C38;

A34-B4-C39;

A34-B4-C40;

A34-B4-C41;

A34-B4-C42;

A34-B4-C43;

A34-B4-C44;

A34-B4-C45;

A34-B4-C46;

A34-B4-C47;

A34-B4-C48;

A34-B4-C49;

A34-B4-C50;

A34-B4-C51;

A34-B4-C52;

A34-B4-C53;

A34-B4-C54;

A34-B4-C55;

A34-B4-C56;

A34-B4-C57;

A34-B4-C58;

A34-B4-C59;

A34-B4-C60;

A34-B4-C61;

A34-B4-C62;

A34-B4-C63;

A34-B4-C64;

A34-B4-C65;

A34-B4-C66;

A34-B4-C67;

A34-B4-C68;

A35-B4-C1;

-152-

A35-B4-C2;

A35-B4-C3;

A35-B4-C4;

A35-B4-C5;

A35-B4-C6;

A35-B4-C7;

A35-B4-C8;

A35-B4-C9;

A35-B4-C10;

A35-B4-C11;

A35-B4-C12;

A35-B4-C13;

A35-B4-C14;

A35-B4-C15;

A35-B4-C16;

A35-B4-C17;

A35-B4-C18;

A35-B4-C19;

A35-B4-C20;

A35-B4-C21;

A35-B4-C22;

A35-B4-C23;

A35-B4-C24;

A35-B4-C25;

A35-B4-C26;

A35-B4-C27;

A35-B4-C28;

(

A35-B4-C29;

A35-B4-C30;

A35-B4-C31;

A35-B4-C32;

A35-B4-C33;

A35-B4-C34;

A35-B4-C35;

A35-B4-C36;

A35-B4-C37;

A35-B4-C38;

A35-B4-C39;

A35-B4-C40;

A35-B4-C41;

A35-B4-C42;

A35-B4-C43;

A35-B4-C44;

A35-B4-C45;

A35-B4-C46;

A35-B4-C47;

A35-B4-C48;

A35-B4-C49;

A35-B4-C50;

A35-B4-C51;

A35-B4-C52;

A35-B4-C53;

A35-B4-C54;

A35-B4-C55;

A35-B4-C56;

A35-B4-C57;

A35-B4-C58;

A35-B4-C59;

A35-B4-C60;

A35-B4-C61;

A35-B4-C62;

A35-B4-C63;

A35-B4-C64;

A35-B4-C65;

A35-B4-C66;

A35-B4-C67;

A35-B4-C68;

A36-B4-C1;

A36-B4-C2;

A36-B4-C3;

A36-B4-C4;

A36-B4-C5;

A36-B4-C6;

A36-B4-C7;

A36-B4-C8;

A36-B4-C9;

A36-B4-C10;

A36-B4-C11;

A36-B4-C12;

A36-B4-C13;

A36-B4-C14;

A36-B4-C15;

A36-B4-C16;

A36-B4-C17;

A36-B4-C18;

A36-B4-C19;

A36-B4-C20;

A36-B4-C21;

A36-B4-C22;

A36-B4-C23;

A36-B4-C24;

A36-B4-C25;

A36-B4-C26;

A36-B4-C27;

A36-B4-C28;

A36-B4-C29;

A36-B4-C30;

A36-B4-C31;

A36-B4-C32;

A36-B4-C33;

A36-B4-C34;

A36-B4-C35;

A36-B4-C36;

A36-B4-C37;

A36-B4-C38;

A36-B4-C39;

A36-B4-C40;

A36-B4-C41;

A36-B4-C42;

A36-B4-C43;

A36-B4-C44;

A36-B4-C45;

A36-B4-C46;

A36-B4-C47;

A36-B4-C48;

A36-B4-C49;

A36-B4-C50;

A36-B4-C51;

A36-B4-C52;

A36-B4-C53;

A36-B4-C54;

A36-B4-C55;

A36-B4-C56;

A36-B4-C57;

A36-B4-C58;

A36-B4-C59;

A36-B4-C60;

A36-B4-C61;

A36-B4-C62;

A36-B4-C63;

A36-B4-C64;

A26-K4-C65-

A36-B4-C66;

A36-B4-C67;

A36-B4-C68;

A37-B4-C1;

A37-B4-C2;

A37-B4-C3;

A37-B4-C4;

A37-B4-C5;

A37-B4-C6;

A37-B4-C7;

A37-B4-C8;

A37-B4-C9;

A37-B4-C10;

A37-B4-C11;

A37-B4-C12;

A37-B4-C13;

A37-B4-C14;

A37-B4-C15;

A37-B4-C16;

A37-B4-C17;

A37-B4-C18;

A37-B4-C19;

A37-B4-C20;

A37-B4-C21;

A37-B4-C22;

A37-B4-C23;

A37-B4-C24;

A37-B4-C25;

A37-B4-C26;

A37-B4-C27;

A37-B4-C28;

A37-B4-C29;

A37-B4-C30;

-153A37-B4-C31;

A37-B4-C32;

A37-B4-C33;

A37-B4-C34;

A37-B4-C35;

A37-B4-C36;

A37-B4-C37;

A37-B4-C38;

A37-B4-C39;

A37-B4-C40;

A37-B4-C41;

A37-B4-C42;

A37-B4-C43;

A37-B4-C44;

A37-B4-C45;

A37-B4-C46;

A37-B4-C47;

A37-B4-C48;

A37-B4-C49;

A37-B4-C50;

A37-B4-C51;

A37-B4-C52;

A37-B4-C53;

A37-B4-C54;

A37-B4-C55;

A37-B4-C56;

A37-B4-C57;

A37-B4-C58;

A37-B4-C59;

A37-B4-C60;

A37-B4-C61;

A37-B4-C62;

A37-B4-C63;

A37-B4-C64;

A37-B4-C65;

A37-B4-C66;

A37-B4-C67;

A37-B4-C68;

A38-B4-C1;

A38-B4-C2;

A38-B4-C3;

A38-B4-C4;

A38-B4-C5;

A38-B4-C6;

A38-B4-C7;

A38-B4-C8;

A38-B4-C9;

A38-B4-C10;

A38-B4-C11;

A38-B4-C12;

A38-B4-C13;

A38-B4-C14;

A38-B4-C15;

A38-B4-C16;

A38-B4-C17;

A38-B4-C18;

A38-B4-C19;

A38-B4-C20;

A38-B4-C21;

A38-B4-C22;

A38-B4-C23;

A38-B4-C24;

A38-B4-C25;

A38-B4-C26;

A38-B4-C27;

A38-B4-C28;

A38-B4-C29;

A38-B4-C30;

A38-B4-C31;

A38-B4-C32;

A38-B4-C33;

A38-B4-C34;

A38-B4-C35;

A38-B4-C36;

A38-B4-C37;

A38-B4-C38;

A38-B4-C39;

A38-B4-C40;

A38-B4-C41;

A38-B4-C42;

A38-B4-C43;

A38-B4-C44;

A38-B4-C45;

A38-B4-C46;

A38-B4-C47;

A38-B4-C48;

A38-B4-C49;

A38-B4-C50;

A38-B4-C51;

A38-B4-C52;

A38-B4-C53;

A38-B4-C54;

A38-B4-C55;

A38-B4-C56;

A38-B4-C57;

A38-B4-C58;

A38-B4-C59;

A38-B4-C60;

A38-B4-C6I;

A38-B4-C62;

A38-B4-C63;

A38-B4-C64;

A38-B4-C65;

A38-B4-C66;

A38-B4-C67;

A38-B4-C68;

A1-B5-C1;

A1-B5-C2;

A1-B5-C3;

A1-B5-C4;

A1-B5-C5;

A1-B5-C6;

A1-B5-C7;

A1-B5-C8;

A1-B5-C9;

A1-B5-C10;

A1-B5-C11;

A1-B5-C12;

A1-B5-C13;

A1-BS-C14;

A1-B5-C15;

A1-B5-C16;

A1-B5-C17;

A1-B5-C18;

A1-B5-C19;

A1-B5-C20;

A1-B5-C21;

A1-B5-C22;

A1-B5-C23;

A1-B5-C24;

A1-B5-C25;

A1-B5-C26;

A1-B5-C27;

A1-B5-C28;

A1-B5-C29;

A1-B5-C30;

A1-B5-C31;

A1-B5-C32;

A1-B5-C33;

A1-B5-C34;

A1-BS-C35;

A1-B5-C36;

A1-B5-C37;

A1-B5-C38;

A1-B5-C39;

A1-B5-C40;

A1-B5-C41;

A1-B5-C42;

A1-B5-C43;

A1-B5-C44;

A1-B5-C45;

A1-BS-C46;

A1-B5-C47;

A1-B5-C48;

A1-B5-C49;

A1-B5-C50;

A1-B5-C51;

A1-B5-C52;

A1-B5-C53;

A1-B5-C54;

A1-B5-C55;

A1-B5-C56;

A1-B5-C57;

A1-B5-C58;

A1-B5-C59;

- 154 -

A1-B5-C60;

A1-B5-C61;

A1-B5-C62;

A1-B5-C63;

A1-B5-C64;

A1-B5-C65;

A1-B5-C66;

A1-B5-C67;

A1-B5-C68;

A2-B5-C1;

A2-B5-C2;

A2-B5-C3;

A2-B5-C4;

A2-B5-C5;

A2-B5-C6;

A2-B5-C7;

A2-B5-C8;

A2-B5-C9;

A2-B5-C10;

A2-B5-C11;

A2-B5-C12;

A2-B5-C13;

A2-B5-C14;

A2-B5-C15;

A2-B5-C16;

A2-B5-C17;

A2-B5-C18;

AND

A2-B5-C19;

A2-B5-C20;

A2-B5-C21;

A2-B5-C22;

A2-B5-C23;

A2-B5-C24;

A2-B5-C25;

A2-B5-C26;

A2-B5-C27;

A2-B5-C28;

A2-B5-C29;

A2-B5-C30;

A2-B.7-C31;

A2-B5-C32;

A2-B5-C33;

A2-B5-C34;

A2-B5-C35;

A2-B5-C36;

A2-B5-C37;

A2-B5-C38;

A2-B5-C39;

A2-B5-C40;

A2-B5-C41;

A2-B5-C42;

A2-B5-C43;

A2-B5-C44;

A2-B5-C45;

A2-B5-C46;

A2-B5-C47;

A2-B5-C48;

A2-B5-C49;

A2-B5-C50;

A2-B5-C51;

A2-B5-C52;

A2-B5-C53;

A2-B5-C54;

A2-B5-C55;

A2-B5-C56;

A2-B5-C57;

A2-B5-C58;

A2-B5-C59;

A2-B5-C60;

A2-B5-C61;

A2-B5-C62;

A2-B5-C63;

A2-B5-C64;

A2-B5-C65;

A2-B5-C66;

A2-B5-C67;

A2-B5-C68;

A3-B5-C1;

A3-B5-C2;

A3-B5-C3;

A3-B5-C4;

A3-B5-C5;

A3-B5-C6;

A3-B5-C7;

A3-B5-C8;

A3-B5-C9;

A3-B5-C10;

A3-B5-C11;

A3-B5-C12;

A3-B5-C13;

A3-B5-C14;

A3-B5-C15;

A3-B5-C16;

A3-B5-C17;

A3-B5-C18;

A3-B5-C19;

A3-B5-C20;

A3-B5-C21;

A3-B5-C22;

A3-B5-C23;

A3-B5-C24;

A3-B5-C25;

A3-B5-C26;

A3-B5-C27;

A3-B5-C28;

A3-B5-C29;

A3-B5-C30;

A3-B5-C31;

A3-B5-C32;

A3-B5-C33;

A3-B5-C34;

A3-B5-C35;

A3-B5-C36;

A3-B5-C37;

A3-B5-C38;

A3-B5-C39;

A3-B5-C40;

A3-B5-C41;

A3-B5-C42;

A3-B5-C43;

A3-B5-C44;

A3-B5-C45;

A3-B5-C46;

A3-B5-C47;

A3-B5-C48;

A3-B5-C50;

A3-B5-C50;

A3-B5-C51;

A3-B5-C52;

A3-B5-C53;

A3-B5-C54;

A3-B5-C55;

A3-B5-C55;

A3-B5-C57;

A3-B5-C58;

A3-B5-C59;

A3-B5-C60;

A3-B5-C61;

A3-B5-C62;

A3-B5-C63;

A3-B5-C64;

A3-B5-C65;

A3-B5-C66;

A3-B5-C67;

A3-B5-C68;

A4-B5-C1;

A4-B5-C2;

A4-B5-C3;

A4-B5-C4;

A4-B5-C4;

A4-B5-C6;

A4-B5-C8;

A4-B5-C8;

A4-B5-C9;

A4-B5-C10;

A4-B5-C12;

A4-B5-C12;

A4-B5-C13;

A4-B5-C14;

A4-B5-C14;

A4-B5-C17;

A4-B5-C17;

A4-B5-C18;

A4-B5-C19;

A4-B5-C20;

·· · β · · • • · • •

-155-

··· ♦ · · # ··· ·· ··· A4-B5-C21; A4-B5-C54; A5-B5-C19; A5-B5-C52; A6-B5-C17; A4-B5-C22; A4-B5-C55; A5-B5-C20; A5-B5-C53; A6-B5-C18; A4-B5-C23; A4-B5-C55; A5-B5-C21; A5-B5-C54; A6-B5-C19; A4-B5-C24; A4-B5-C57; A5-B5-C22; A5-B5-C55; A6-B5-C20; A4-B5-C25; A4-B5-C58; A5-B5-C23; A5-B5-C55; A6-B5-C21; A4-B5-C26; A4-B5-C59; A5-B5-C24; A5-B5-C57; A6-B5-C22; A4-B5-C27; A4-B5-C60; A5-B5-C25; A5-B5-C58; A6-B5-C23; A4-B5-C28; A4-B5-C61; A5-B5-C26; A5-B5-C59; A6-B5-C24; A4-B5-C29; A4-B5-C62; A5-B5-C27; A5-B5-C60; A6-B5-C25; A4-B5-C30; A4-B5-C63; A5-B5-C28; A5-B5-C61; A6-B5-C26; A4-B5-C30; A4-B5-C64; A5-B5-C29; A5-B5-C62; A6-B5-C27; A4-B5-C32; A4-B5-C65; A5-B5-C30; A5-B5-C63; A6-B5-C28; A4-B5-C33; A4-B5-C66; A5-B5-C31; A5-B5-C64; A6-B5-C29; A4-B5-C34; A4-B5-C67; A5-B5-C32; A5-B5-C65; A6-B5-C30; A4-B5-C35; A4-B5-C68; A5-B5-C33; A5-B5-C66; A6-B5-C31; A4-B5-C36; A5-B5-C1; A5-B5-C34; A5-B5-C67; A6-B5-C32; A4-B5-C37; A5-B5-C2; A5-B5-C35; A5-B5-C68; A6-B5-C33; A4-B5-C38; A5-B5-C3; A5-B5-C36; A6-B5-C1; A6-B5-C34; A4-B5-C39; A5-B5-C4; A5-B5-C37; A6-B5-C2; A6-B5-C35; A4-B5-C40; A5-B5-C5; A5-B5-C38; A6-B5-C3; A6-B5-C36; A4-B5-C41; A5-B5-C6; A5-B5-C39; A6-B5-C4; A6-BS-C37; A4-B5-C42; A5-B5-C7; A5-B5-C40; A6-B5-C5; A6-B5-C38; A4-B5-C43; A5-B5-C8; A5-B5-C41; A6-B5-C6; 66-B5-C39; A4-B5-C44; A5-B5-C9; A5-B5-C42; A6-B5-C7; A6-B5-C40; A4-B5-C45; A5-B5-C10; A5-B5-C43; A6-B5-C8; A6-B5-C41; A4-B5-C46; A5-B5-C11; A5-B5-C44; A6-B5-C9; A6-B5-C42; A4-B5-C47; A5-B5-C12; A5-B5-C45; A6-B5-C10; A6-B5-C43; A4-B5-C48; A5-B5-C13; A5-B5-C46; A6-B5-C11; A6-B5-C44; A4-B5-C50; A5-B5-C14; A5-B5-C47; A6-B5-C12; A6-B5-C45; A4-B5-C50; A5-B5-C15; A5-B5-C48; A6-B5-C13; A6-B5-C46; A4-B5-C51; A5-B5-C16; A5-B5-C49; A6-B5-C14; A6-B5-C47; A4-B5-C52; A5-B5-C17; A5-B5-C50; A6-B5-C15; A6-B5-C48; A4-B5-C53; A5-B5-C18; A5-B5-C51; A6-B5-C16; A6-B5-C49;

-156A.6-B5-C50;

A6-B5-C51;

A6-B5-C52;

A6-B5-C53;

A6-B5-C54;

A6-B5-C55;

A6-B5-C55;

A6-B5-C57;

A6-B5-C58;

A6-B5-C59;

A6-B5-C60;

A6-B5-C61;

A6-B5-C62;

A6-B5-C63;

A6-B5-C64;

A6-B5-C65;

A6-B5-C66;

A6-B5-C67;

A6-B5-C68;

A7-B5-C1;

A7-B5-C2;

A7-B5-C3;

A7-B5-C4;

A7-B5-C5;

A7-B5-C6;

A7-B5-C7;

Α7-Β5- £ 8;

A7-B5-C9;

77-B5-C10;

A7-B5-C11;

A7-B5-C12;

A7-B5-C13;

A7-B5-C14;

A7-B5-C15;

A7-B5-C16;

A7-B5-C17;

77-B5-C18;

A7-B5-C19;

A7-B5-C20;

A7-B5-C21;

A7-B5-C22;

A7-B5-C23;

A7-B5-C24;

A7-B5-C25;

A7-B5-C26;

A7-B5-C27;

A7-B5-C28;

A7-B5-C29;

A7-B5-C30;

A7-B5-C31;

77-B5-C32;

A7-B5-C33;

A7-B5-C34;

A7-B5-C35;

A7-B5-C36;

A7 B5-C37;

A7-B5-C38;

A7-B5-C39;

77-B5-C40;

A7-B5-C41;

A7-B5-C42;

A7-B5-C43;

A7-B5-C44;

A7-B5-C45;

A7-B5-C46;

A7-B5-C47;

77-B5-C48;

77-B5-C49;

A7-B5-C50;

A7-B5-C51;

77-B5-C52;

A7-B5-C53;

A7-B5-C54;

A7-B5-C55;

A7-B5-C56;

77-B5-C57;

77-B5-C58;

A7-B5-C59;

A7-B5-C60;

A7-B5-C61;

A7-B5-C62;

A7-B5-C63;

77-B5-C64;

A7-B5-C65;

A7-B5-C66;

A7-B5-C67;

A7-B5-C68;

A8-B5-C1;

A8-B5-C2;

A8-B5-C3;

A8-B5-C4;

A8-B5-C5;

A8-B5-C6;

A8-B5-C7;

A8-B5-C8;

A8-B5-C9;

A8-B5-C10;

A8-B5-C11;

A8-B5-Cl2;

A8-B5-C13;

A8-B5-C14;

A8-B5-C15;

A8-B5-C16;

A8-B5-C17;

A8-B5-C18;

A8-B5-C19;

A8-B5-C20;

A8-B5-C21;

A8-B5-C22;

A8-B5-C23;

A8-B5-C24;

A8-B5-C25;

A8-B5-C26;

A8-B5-C27;

A8-B5-C28;

A8-B5-C29;

A8-B5-C30;

A8-B5-C31;

A8-B5-C32;

A8-B5-C33;

A8-B5-C34;

A8-B5-C35;

A8-B5-C36;

A8-B5-C37;

A8-B5-C38;

A8-B5-C39;

A8-B5-C40;

A8-B5-C41;

A8-B5-C42;

A8-B5-C43;

A8-B5-C44;

A8-B5-C45;

A8-B5-C46;

A8-B5-C47;

A8-B5-C48;

88-B5-C49;

A8-B5-C50;

A8-B5-C51;

A8-B5-C52;

A8-B5-C53;

A8-B5-C54;

A8-B5-C55;

A8-B5-C56;

A8-B5-C57;

A8-B5-C58;

A8-B5-C59;

A8-B5-C60;

A8-B5-C61;

A8-B5-C62;

A8-B5-C63;

A8-B5-C64;

A8-B5-C65;

A8-B5-C66;

A8-B5-C67;

A8-B5-C68;

A9-B5-C1;

A9-B5-C2;

A9-B5-C3;

A9-B5-C4;

A9-B5-C5;

A9-B5-C6;

A9-B5-C7;

A9-B5-C8;

A9-B5-C9;

99-B5-C10;

157 A9-B5-C11;

99-B5-CX2;

A9-B5-C13;

99-B5-CX4;

9 9 -B 5 -C 15;

99-B5-C16;

99-B5-CX7;

99-B5-C18;

A9-B5-CX9;

A9-B5-C20;

A9-B5-C21;

A9-B5-C22;

99-B5-C23;

99-B5-C24;

99-B5-C25;

99-B5-C26;

A9-B5-C27;

A9-B5-C28;

A9-B5-C29;

99-B5-C30;

99-B5-C31;

99-B5-C32;

99-B5-C33;

99-B5-C34;

99-B5-C35;

99-B5-C36;

99-B5-C37;

99-B5-C38;

99-B5-C39;

99-B5-C40;

99-B5-C41;

99-B5-C42;

99-B5-C43;

99-B5-C44;

99-B5-C45;

99-B5-C46;

99-B5-C47;

99-B5-C48;

99-B5-C49;

99-B5-C50;

99-B5-C51;

99-B5-C52;

99-B5-C53;

99-B5-C54;

99-B5-C55;

99-B5-C56;

A9-B5-C57;

99-B5-C58;

99-B5-C59;

99-B5-C60;

99-B5-C61;

99-B5-C62;

99-B5-C63;

99-B5-C64;

99-B5-C65;

99-B5-C66;

99-B5-C67;

99-B5-C68;

A10-B5-C1;

A10-B5-C2;

A1Q-B5-C3;

A10-B5-C4;

A10-B5-C5;

A10-B5-C6;

A10-B5-C7;

AX0-B5-C7;

A10-B5-C9;

A10-B5-C10;

A10-B5-C11;

A10-B5-C12;

A10-B5-C13;

A10-B5-C14;

A10-B5-C15;

A10-B5-C16;

A10-B5-C17;

AX0-B5-CX7;

A10-B5-C19;

A10-B5-C20;

A10-B5-C21;

AX0-B5-C22;

A10-B5-C23;

A10-B5-C24;

A10-B5-C25;

A10-B5-C26;

A10-B5-C27;

A10-B5-C28;

AX0-B5-C29;

A10-B5-C30;

A10-B5-C31;

A10-B5-C32;

A10-B5-C33;

A10-B5-C34;

A10-B5-C35;

A10-B5-C36;

A10-B5-C37;

A10-B5-C38;

A10-B5-C39;

AX0-B5-C40;

AX0-BS-C4I;

A10-B5-C42;

A10-B5-C43;

A10-B5-C44;

A10-B5-C45;

A10-B5-C46;

A10-B5-C47;

A10-B5-C48;

A10-B5-C49;

A10-B5-C50;

A10-B5-C51;

AX0-B5-C52;

A10-B5-C53;

A10-B5-C54;

A10-B5-C55;

A10-B5-C56;

A10-B5-C57;

A10-B5-CS8;

A10-B5-C59;

A1Q-B5-C60;

A10-B5-C61;

A10-B5-C62;

A10-B5-C63;

A10-B5-C64;

A10-B5-C65;

AX0-B5-C66;

AX0-B5-C68;

AX0-B5-C68;

A11-B5-C1;

AX1-B5-C2;

A11-B5-C3;

A11-B5-C4;

A11-B5-C5;

AIX-BS-C6;

A11-B5-C7;

A11-B5-C8;

A11-B5-C9;

AXX-B5-CX1;

AX1-B5-CXX

AXX-B5-CX1;

AIX-B5-CX2;

AXX-B5-CX5;

AXI-B5-CX4;

AXX-B5-CX7;

AXX-B5-C18;

AXX-B5-CX7;

AXX-B5-CX8;

AX1-B5-C20;

AXX-B5-C2X;

AXX-B5-C22

AXX-B5-C22;

AXX-B5-C22;

AXX-B5-C25

AXX-B5-C25;

AXX-B5-C28;

AXX-B5-C27;

AXX-B5-C30;

AXX-B5-C30

A1X-B5-C3X;

AXX-B5-C33;

A11-B5-C33;

AXX-B5-C33;

AXX-B5-C40;

AXX-B5-C35;

AXX-B5-C36;

A1X-B5-C38;

AXX-BS-C40;

-158-

············································

A11-B5-C40;

A11-B5-C41;

A11-B5-C42;

A11-B5-C43;

A11-B5-C44;

A11-B5-C45;

A11-B5-C46;

A11-B5-C47;

A11-B5-C48;

A11-B5-C49;

A11-B5-C50;

A11-B5-C51;

A11-B5-C52;

A11-B5-C53;

A11-B5-C54;

A11-B5-C55;

A11-B5-C56;

A11-B5-C57;

A11-B5-C58;

A11-B5-C59;

A11-B5-C60;

A11-B5-C61;

A11-B5-C62;

A11-B5-C63;

A11-B5-C64;

A11-B5-C65;

A11-BS-C66;

A11-B5-C67;

A11-B5-C68;

A12-B5-C1;

A12-B5-C2;

A12-B5-C3;

A12-B5-C4;

A12-B5-C5;

A12-B5-C6;

A12-B5-C7;

A12-B5-C8;

A12-B5-C9;

A12-B5-C10;

A12-B5-C11;

A12-B5-C12;

A12-B5-C13;

A12-B5-C14;

A12-B5-C15;

A12-B5-C16;

A12-B5-C17;

A12-B5-C18;

A12-B5-C19;

A12-B5-C20;

A12-B5-C21;

A12-B5-C22;

A12-B5-C23;

A12-B5-C24;

A12-B5-C25;

A12-B5-C26;

A12-B5-C27;

A12-B5-C28;

A12-B5-C29;

A12-B5-C30;

A12-B5-C31;

A12-B5-C32;

A12-B5-C33;

A12-B5-C34;

A12-B5-C35;

A12-B5-C36;

A12-B5-C37;

A12-B5-C38;

A12-B5-C39;

A12-B5-C40;

A12-B5-C41;

A12-B5-C42;

A12-B5-C43;

A12-B5-C44;

A12-B5-C45;

A12-B5-C46;

A12-B5-C47;

A12-B5-C48;

A12-B5-C49;

A12-B5-C50;

A12-B5-C51;

A12-B5-C52;

A12-B5-C53;

A12-B5-C54;

A12-B5-C55;

A12-B5-C56;

A12-B5-C57;

A12-B5-C58;

A12-B5-C59;

A12-B5-C60;

A12-B5-C61;

A12-B5-C62;

A12-B5-C63;

A12-B5-C64;

A12-B5-C65;

A12-B5-C66;

A12-B5-C67;

A12-B5-C68;

A13-B5-C1;

A13-B5-C2;

A13-B5-C3;

A13-B5-C4;

A13-B5-C5;

A13-B5-C6;

A13-B5-C7;

A13-B5-C8;

A13-B5-C9;

A13-B5-C10;

A13-B5-C11;

A13-B5-C12;

A13-B5-C13;

A13-B5-C14;

A13-B5-C15;

A13-B5-C16;

A13-B5-C17;

A13-B5-C18;

A13-B5-C19;

A13-B5-C20;

A13-B5-C21;

A13-B5-C22;

A13-B5-C23;

A13-B5-C24;

A13-B5-C25;

A13-B5-C26;

A13-B5-C27;

A13-B5-C28;

A13-B5-C29;

A13-B5-C30;

A13-B5-C31;

A13-B5-C32;

A13-B5-C33;

A13-B5-C34;

A13-B5-C35;

A13-BS-C36;

A13-B5-C37;

A13-B5-C38;

A13-B5-C39;

A13-B5-C40;

A13-B5-C41;

A13-B5-C42;

A13-B5-C43;

A13-B5-C44;

A13-B5-C45;

A13-B5-C46;

A13-B5-C47;

A13-B5-C48;

A13-B5-C49;

A13-B5-C50;

A13-B5-C51;

A13-B5-C52;

A13-B5-C53;

A13-B5-C54;

A13-B5-C55;

A13-B5-C56;

A13-B5-C57;

A13-B5-C58;

A13-B5-C59;

A13-B5-C60;

A13-B5-C61;

A13-B5-C62;

A13-B5-C63;

A13-B5-C64;

A13-B5-C65;

A13-B5-C66;

A13-B5-C67;

A13-B5-C68;

-159A14-B5-C1;

A14-B5-C2;

A14-B5-C3;

A14-B5-C4;

A14-B5-CS;

A14-B5-C6;

A14-B5-C7;

A14-B5-C8;

A14-B5)

A14-B5-C10;

A14-B5-C11;

A14-B5-C12;

A14-B5-C13;

A14-B5-C14;

A14-B5-C15;

A14- BS-C16;

A14-B5-C17;

A14-B5-C18;

A14-B5-C19;

A14-B5-C20;

A14-B5-C21;

A14-B5-C22;

A14-B5-C23;

A14-B5-C24;

A14-B5-C25;

A14-B5-C26;

A14-B5-C27;

A14 - BS - C28;

A14-B5-C29;

A14-B5-C30;

A14-B5-C31;

A14-B5-C32;

A14-B5-C33;

A14-B5-C34;

A14-B5-C35;

A14-B5-C36;

A14-B5-C37;

A14-B5-C38;

A14-B5-C39;

A14-B5-C40;

A14-B5-C41;

A14-B5-C42;

A14-B5-C43;

A14-B5-C44;

A14-B5-C45;

A14-B5-C46;

A14-B5-C47;

A14-B5-C48;

A14-B5-C49;

A14-B5-C50;

A14-B5-C51;

A14-B5-C52;

A14-B5-C53;

A14-B5-C54;

A14-B5-C55;

A14-B5-C56;

A14- BS-C57;

A14-B5-C58;

A14-B5-C59;

A14-B5-C60;

A14-B5-C61;

A14-B5-C62;

A14-B5-C63;

A14-B5-C64;

A14-B5-C65;

A14-B5-C66;

A14-B5-C67;

A14-B5-C68;

A15-B5-C1;

A15-B5-C2;

A15-B5-C3;

A15-B5-C4;

A15-B5-C5;

A15-B5-C6;

A15-B5-C7;

A15-B5-C8;

A15-B5-C9;

A15-B5-C10;

A15-B5-C11;

A15-B5-C12;

A15-B5-C13;

A15-B5-C14;

A15-B5-C15;

A15-B5-C16;

A15-B5-C17;

A15-B5-C18;

A15-B5-C19;

A15-B5-C20;

A15-B5-C21;

A15-B5-C22;

A15-B5-C23;

A15-B5-C24;

A15-B5-C25;

A15-B5-C26;

A15-B5-C27;

A15-B5-C28;

A15-B5-C29;

A15-B5-C30;

A15-B5-C31;

A15-B5-C32;

A15-B5-C33;

A15-B5-C34;

A15-B5-C35;

A15-B5-C36;

A15-B5-C37;

A15-B5-C38;

A15-B5-C39;

A15-B5-C40;

A15-B5-C41;

A15-B5-C42;

A15-B5-C43;

A15-B5-C44;

A15-B5-C45;

A15-B5-C46;

A15-B5-C47;

A15-B5-C48;

A15-B5-C49;

A15-B5-C50;

A15-B5-C51;

A15-B5-C52;

A15-B5-C53;

A15-B5-C54;

A15-B5-C55;

A15-B5-C56;

A15-B5-C57;

A15-B5-C58;

A15-B5-C59;

A15-B5-C60;

A15-B5-C61;

A15-B5-C62;

A15-B5-C63;

A1S-B5-C64;

A15-B5-C65;

A15-B5-C66;

A15-B5-C67;

A15-B5-C68;

A16-B5-C1;

A16-B5-C2;

A16-B5-C3;

A16-B5-C4;

A16-B5-C5;

A16-B5-C6;

A16-B5-C7;

A16-B5-C8;

A16-B5-C9;

A16-B5-C10;

A16-B5-C11;

A16-B5-C12;

A16-B5-C13;

A16-B5-C14;

A16-B5-C15;

A16-B5-C16;

A16-B5-C17;

A16-B5-C18;

A16-B5-C19;

A16-B5-C20;

A16-B5-C21;

A16-B5-C22;

A16-B5-C23;

A16-B5-C24;

A16-B5-C25;

A16-B5-C26;

A16-B5-C27;

A16-B5-C28;

Al6-BS-C29;

-160 A16-B5-C30;

A16-B5-C31;

A16-B5-C32;

A16-B5-C33;

A16-B5-C34;

A16-B5-C35;

A16-B5-C36;

A16-B5-C37;

A16-B5-C38;

A16-B5-C39;

A16-B5-C40;

A16-B5-C41;

A16-B5-C42;

A16-B5-C43;

A16-B5-C44;

A16-B5-C45;

A16-B5-C46;

A16-B5-C47;

A16-B5-C48;

A16-B5-C49;

A16-B5-C50;

A16-B5-C51;

A16-B5-C52;

A16-B5-C53;

A16-B5-C54;

A16-B5-C55;

A16-B5-C56;

A16-B5-C57;

A16-B5-C58;

A16-B5-C59;

A16-B5-C60;

A16-B5-C61;

A16-B5-C62;

A16-B5-C63;

A16-B5-C64;

A16-B5-C65;

A16-B5-C66;

A16-B5-C67;

A16-B5-C68;

A17-B5-C1;

A17-B5-C2;

A17-B5-C3;

A17-B5-C4;

A17-B5-C5;

A17-B5-C6;

A17-B5-C7;

A17-B5-C8;

A17-B5-C9;

A17-B5-C10;

A17-B5-C11;

A17-B5-C12;

A17-B5-C13;

A17-B5-C14;

A17-B5-C15;

A17-B5-C16;

A17-B5-C17;

A17-B5-C18;

A17-B5-C19;

A17-B5-C20;

A17-B5-C21;

A17-B5-C22;

A17-B5-C23;

A17-B5-C24;

A17-B5-C25;

A17-B5-C26;

A17-B5-C27;

A17-B5-C28;

A17-B5-C29;

A17-B5-C30;

A17-B5-C31;

A17-B5-C32;

A17-B5-C33;

A17-B5-C34;

A17-B5-C35;

A17-B5-C36;

A17-B5-C37;

A17-B5-C38;

A17-B5-C39;

A17-B5-C40;

A17-B5-C41;

A17-B5-C42;

A17-B5-C43;

A17-B5-C44;

A17-B5-C45;

A17-B5-C46;

A17-B5-C47;

A17-B5-C48;

A17-B5-C49;

A17-B5-C50;

A17-B5-C51;

A17-B5-C52;

A17-B5-C53;

A17-B5-C54;

A17-B5-C55;

A17-B5-C56;

A17-B5-C57;

A17-B5-C58;

A17-B5-C59;

A17-B5-C60;

A17-B5-C61;

A17-B5-C62;

A17-B5-C63;

A17-B5-C64;

A17-B5-C65;

A17-B5-C66;

A17-B5-C67;

A17-B5-C68;

A18-B5-C1;

A18-B5-C2;

A18-B5-C3;

A18-B5-C4;

A18-B5-C5;

A18-B5-C6;

A18-B5-C7;

A18-B5-C8;

A18-B5-C9;

A18-B5-C10;

A18-B5-C11;

A18-B5-C12;

A18-B5-C13;

A18-B5-C14;

A18-B5-C15;

A18-B5-C16;

A18-B5-C17;

A18-B5-C18;

A18-B5-C19;

A18-B5-C20;

A18-B5-C21;

A18-B5-C22;

A18-B5-C23;

A18-B5-C24;

A18-B5-C25;

A18-B5-C26;

A18-B5-C27;

A18-B5-C28;

A18-B5-C29;

A18-B5-C30;

A18-B5-C31;

A18-B5-C32;

A18-B5-C33;

A18-B5-C34;

A18-B5-C35;

A18-B5-C36;

A18-B5-C37;

A18-B5-C38;

A18-B5-C39;

A18-B5-C40;

A18-B5-C41;

A18-B5-C42;

A18-B5-C43;

A18-B5-C44;

A18-B5-C45;

A18-B5-C46;

A18-B5-C47;

Α18-Β5-φ48;

A18-B5-C49;

A18-B5-C50;

A18-B5-C51;

A18-B5-C52;

A18-B5-C53;

A18-B5-C54;

A18-B5-C55;

A18-B5-C56;

A18-B5-C57;

A18-B5-C58;

-161 -

A18-B5-C59;

A18-B5-C60;

A18-B5-C61;

A18-B5-C62;

A18-B5-C63;

A18-B5-C64;

A18-B5-C65;

A18-B5-C66;

A18-B5-C67;

A18-B5-C68;

A19-B5-C1;

A19-B5-C2;

A19-B5-C3;

A19-B5-C4;

A19-B5-C5;

A19-B5-C6;

A19-B5-C7;

A19-B5-C8;

A19-B5-C9;

A19-B5-C10;

A19-B5-C11;

A19-B5-C12;

A19-B5-C13;

A19-B5-C14;

A19-B5-C15;

A19-B5-C16;

A19-B5-C17;

A19-B5-C18;

A19-B5-C19;

A19-B5-C20;

A19-B5-C21;

A19-B5-C22;

A19-B5-C23;

A19-B5-C24;

A19-B5-C25;

A19-B5-C26;

A19-B5-C27;

A19-B5-C28;

A19-B5-C29;

A19-B5-C30;

A19-B5-C31;

A19-B5-C32;

A19-B5-C33;

A19-B5-C34;

A19-B5-C35;

A19-B5-C36;

A19-B5-C37;

A19-B5-C38;

A19-B5-C39;

A19-B5-C40;

A19-B5-C41;

A19-B5-C42;

A19-B5-C43;

A19-B5-C44;

A19-B5-C45;

A19-B5-C46;

A19-B5-C47;

A19-B5-C48;

A19-B5-C49;

A19-B5-C50;

A19-B5-C51;

A19-B5-C52;

A19-B5-C53;

A19-B5-C54;

A19-B5-C55;

A19-B5-C56;

A19-BS-C57;

A19-B5-C58;

A19-B5-C59;

A19-B5-C60;

A19-B5-C61;

A19-B5-C62;

A19-B5-C63;

A19-B5-C64;

A19-B5-C65;

A19-B5-C66;

A19-B5-C67;

A19-B5-C68;

A20-B5-C1;

A20-B5-C2;

A20-B5-C3;

A20-B5-C4;

A20-B5-C5;

A20-B5-C6;

A20-B5-C7;

A20-B5-C8;

A20-B5-C9;

A20-B5-C10;

A20-B5-C11;

A20-B5-C12;

A20-B5-C13;

A20-B5-C14;

A20-B5-C15;

A20-B5-C16;

A20-B5-C17;

A20-B5-C18;

A20-B5-C19;

A20-B5-C20;

A20-B5-C21;

A20-B5-C22;

A20-B5-C23;

A20-B5-C24;

A20-B5-C25;

A20-B5-C26;

A20-B5-C27;

A20-B5-C28;

A20-B5-C29;

A20-B5-C30;

A20-B5-C31;

A20-B5-C32;

A20-B5-C33;

A20-B5-C34;

A20-B5-C35;

A20-B5-C36;

A20-B5-C37;

A20-B5-C38;

A20-B5-C39;

A20-B5-C40;

A20-B5-C41;

A20-B5-C42;

A20-B5-C43;

A20-B5-C44;

A20-B5-C45;

A20-B5-C46;

A20-B5-C47;

A20-B5-C48;

A20-B5-C49;

A20-B5-C50;

A20-B5-C51;

A20-B5-C52;

A20-B5-C53;

A20-B5-C54;

A20-B5-C55;

A20-B5-C56;

A20-B5-C57;

A20-B5-C58;

A20-B5-C59;

A20-B5-C60;

A20-B5-C61;

A20-B5-C62;

A20-B5-C63;

A20-B5-C64;

A20-B5-C65;

A20-B5-C66;

A20-B5-C67;

A20-B5-C68;

A21-B5-C1;

A21-B5-C2;

A21-B5-C3;

A21-B5-C4;

A21-B5-C5;

A21-B5-C6;

A21-B5-C7;

A21-B5-C8;

A21-B5-C9;

A21-B5-C10;

A21-B5-C11;

A21-B5-C12;

A21-B5-C13;

A21-B5-C14;

A21-B5-C15;

A21-B5-C16;

A21-B5-C17;

A21-B5-C18;

A21-B5-C19;

- 162 • - - - - - - - - - -

A21-B5-C20; A21-B5-C53; A22-B5-C18; A22-B5-C51; A23-B5-C16; A21-B5-C21; A21-B5-C54; A22-B5-C19; A22-B5-C52; A23-B5-C17; A21-B5-C22; A21-B5-C55; A22-B5-C20; A22-B5-C53; A23-B5-C18; A21-B5-C23; A21-B5-C56; A22-B5-C21; A22-B5-C54; A23-B5-C19; A21-B5-C24; A21-B5-C57; A22-B5-C22; A22-B5-C55; A23-B5-C20; A21-B5-C25; A21-B5-C58; A22-B5-C23; A22-B5-C56; A23-B5-C21; A21-B5-C26; A21-B5-C59; A22-B5-C24; A22-B5-C57; A23-B5-C22; A21-B5-C27; A21-B5-C60; A22-B5-C25; A22-B5-C58; A23-B5-C23; A21-B5-C28; A21-B5-C61; A22-B5-C26; A22-B5-C59; A23-B5-C24; A21-B5-C29; A21-B5-C62; A22-B5-C27; A22-B5-C60; A23-B5-C25; A21-B5-C30; A21-B5-C63; A22- BS-C28; A22-B5-C61; A23-B5-C26; A21-B5-C31; A21-B5-C64; A22-B5-C29; A22-B5-C62; A23-B5-C27; A21-B5-C32; A21-B5-C65; A22-B5-C30; A22-B5-C63; A23-B5-C28; A21-B5-C33; A21-B5-C66; A22-B5-C31; A22-B5-C64; A23-B5-C29; A21-B5-C34; A21-B5-C67; A22-B5-C32; A22-B5-C65; A23-B5-C30; A21-B5-C35; A21-B5-C68; A22-B5-C33; A22-B5-C66; A23-B5-C31; A21-B5-C36; A22-B5-C1; A22-B5-C34; A22-B5-C67; A23-B5-C32; A21-B5-C37; A22-B5-C2; A22-B5-C35; A22-B5-C68; A23-B5-C33; A21-B5-C38; A22-B5-C3; A22-B5-C36; A23-B5-C1; A23-B5-C34; A21-B5-C39; A22-B5-C4; A22-B5-C37; A23-B5-C2; A23-B5-C35; A21-B5-C40; A22-B5-C5; A22-B5-C38; A23-B5-C3; A23-B5-C36; A21-B5-C41; A22-B5-C6; A22-B5-C39; A23-B5-C4; A23-B5-C37; A21-B5-C42; A22-B5-C7; A22-B5-C40; A23-B5-C5; A23-B5-C38; A21-B5-C43; A22-B5-C8; A22-B5-C41; A23-B5-C6; A23-B5-C39; A21-B5-C44; A22-B5-C9; A22-B5-C42; A23-B5-C7; A23-B5-C40; A21-B5-C45; A22-B5-C10; A22-B5-C43; A23-B5-C8; A23-B5-C41; A21-B5-C46; A22-B5-C11; A22-B5-C44; A23-B5-C9; A23-B5-C42; A21-B5-C47; A22-B5-C12; A22-B5-C45; A23-B5-C10; A23-B5-C43; A21-B5-C48; A22-B5-C13; A22-B5-C46; A23-B5-C11; A23-B5-C44; A21-B5-C49; A22-B5-C14; A22-B5-C47; A23-B5-C12; A23-B5-C45; A21-B5-C50; A22-B5-C15; A22-B5-C48; A23-B5-C13; A23-B5-C46; A21-B5-C51; A22-B5-C16; A22-B5-C49; A23-B5-C14; A23-B5-C47; A21-B5-C52; A22-B5-C17; A22-B5-C50; A23-B5-C15; A23-B5-C48;

-162 • · ·

A23-B5-C49;

A23-B5-C50;

A23-B5-C51;

A23-B5-C52;

A23-B5-C53;

A23-B5-C54;

A23-B5-C55;

A23-B5-C56;

A23-B5-C57;

A23-B5-C58;

A23-B5-C59;

A23-B5-C60;

A23-B5-C61;

A23-B5-C62;

A23-B5-C63;

A23-B5-C64;

A23-B5-C65;

A23-B5-C66;

A23-B5-C67;

A23-B5-C68;

A24-B5-C1;

A24-B5-C2;

A24-B5-C3;

A24-B5-C4;

A24-B5-C5;

A24-B5-C6;

A24-B5-C7;

A24-B5-C8;

A24-B5-C9;

A24-B5-C10;

A24-B5-C11;

A24-B5-C12;

A24-B5-C13;

A24-B5-C14;

A24-B5-C15;

A24-B5-C16;

A24-B5-C17;

A24-B5-C18;

A24-B5-C19;

A24-B5-C20;

A24-B5-C21;

A24-B5-C22;

A24-B5-C23;

A24-B5-C24;

A24-B5-C25;

A24-B5-C26;

A24-B5-C27;

A24-B5-C28;

A24-B5-C29;

A24-B5-C30;

A24-B5-C31;

A24-B5-C32;

A24-B5-C33;

A24-B5-C34;

A24-B5-C35;

A24-B5-C36;

A24-B5-C37;

A24-B5-C38;

A24-B5-C39;

A24-B5-C40;

A24-B5-C41;

A24-B5-C42;

A24-B5-C43;

A24-B5-C44;

A24-B5-C45;

A24-B5-C46;

A24-B5-C47;

A24-B5-C48;

A24-B5-C49;

A24-B5-C50;

A24-B5-O51;

A24-B5-C52;

A24-B5-C53;

A24-B5-C54;

A24-B5-C55;

A24-B5-C56;

A24-B5-C57;

A24-B5-C58;

A24-B5-C59;

A24-B5-C60;

A24-B5-C61;

A24-B5-C62;

A24-B5-C63;

A24-B5-C64;

A24-B5-C65;

A24-B5-C66;

A24-B5-C67;

A24-B5-C68;

2525-B5-C1;

A25-B5-C2;

A25-B5-C3;

A25-B5-C4;

A25-B5-C5;

A25-B5-C6;

A25-B5-C7;

A25-B5-C8;

A25-B5-C9;

A25-B5-C10;

A25-B5-C11;

A25-B5-Cl2;

A25-B5-C13;

A25-B5-C14;

A25-B5-C15;

A25-B5-C16;

A25-B5-C17;

A25-B5-C18;

A25-B5-C19;

A25-B5-C20;

A25-B5-C21;

A25-B5-C22;

A25-B5-C23;

A25-B5-C24;

A25-B5-C25;

A25-B5-C26;

A25-B5-C27;

A25-B5-C28;

A25-B5-C29;

A25-B5-C30;

A25-B5-C31;

A25-B5-C32;

A25-B5-C33;

A25-35-C34;

A25-B5-C35;

A2S-B5-C36;

A25-B5-C37;

A25-B5-C38;

A25-B5-C39;

A25-B5-C40;

A25-B5-C41;

A25-B5-C42;

A25-B5-C43;

A25-B5-C44;

A25-B5-C45;

A25-B5-C46;

A25-B5-C47;

A25-B5-C48;

A25-B5-C49;

A25-B5-C50;

A25-B5-C51;

A25-B5-C52;

A25-B5-C53;

A25-B5-C54;

A25-B5-C55;

A25-B5-C56;

2525-B5-C57;

A25-B5-C58;

A25-B5-C59;

A25-B5-C60;

A25-B5-C61;

A25-B5-C62;

A25-B5-C63;

A25-B5-C64;

A25-B5-C65;

A25-B5-C66;

A25-B5-C67;

A25-B5-C68;

A26-B5-C1;

A26-B5-C2;

A26-B5-C3;

A26-B5-C4;

A26-B5-C5;

A26-B5-C6;

A26-B5-C7;

A26-B5-C8;

A26-B5-C9;

· · ·· · ·

-164 ··· ·· ·· ··· ·· ···

A26-B5-C10; A26-B5-C43; A27-B5-C8; A27-B5-C41; A28-B5-C6; A26-B5-C11; A26-B5-C44; A27-B5-C9; A27-B5-C42; A28-B5-C7; A26-B5-C12; A26-B5-C45; A27-B5-C10; A27-B5-C43; A28-B5-C8; A26-B5-C13; A26-B5-C46; A27-B5-C11; A27-B5-C44; A28-B5-C9; A26-B5-C14; A26-B5-C47; A27-B5-C12; A27-B5-C45; A28-B5-C10; A26-B5-C15; A26-B5-C48; A27-B5-C13; A27-B5-C46; A28-B5-C11; A26-B5-C16; A26-B5-C49; A27-B5-C14; A27-B5-C47; A28-B5-C12; A26-B5-C17; A26-B5-C50; A27-B5-C15; A27-B5-C48; A28-B5-C13; A26-B5-C18; A26-B5-C51; A27-B5-C16; A27-B5-C49; 2828-B5-C14; A26-B5-C19; A26-B5-C52; A27-B5-C17 ^ / A27-B5-C50; A28-B5-C15; A26-B5-C20; A26-B5-C53; A27-B5-C18; A27-B5-C51; A28-B5-C16; A26-B5-C21; A206-B5-C54; A27-B5-C19; A27-B5-C52; A28-B5-C17; A26-B5-C22; A26-B5-C55; A27-B5-C20; A27-B5-C53; A28-B5-C18; A26-B5-C23; A26-B5-C56; A27-B5-C21; A27-B5-C54; A28-B5-C19; A26-B5-C24; A26-B5-C57; A27-B5-C22; A27-B5-C55; A28-B5-C20; A26-B5-C25; A26-B5-C58; A27-B5-C23; A27-B5-C56; A28-B5-C21; A26-B5-C26; A26-B5-C59; A27-B5-C24; A27-B5-C57; A28-B5-C22; A26-B5-C27; A26-B5-C60; A27-B5-C25; A27-B5-C58; A28-B5-C23; A26-B5-C28; A26-B5-C61; A27-B5-C26; A27-B5-C59; A28-B5-C24; A26-B5-C29; A26-B54362; A27-B5-C27; A27-B5-C60; A28-B5-C25; A26-B5-C30; A206-5-C63; A27-B5-C28; A27-B5-C61; A28-B5-C26; A26-B5-C31; A26-B5-C64; A27-B5-C29; A27-B5-C62; A28-B5-C27; A26-B5-C32; A26-B5-C65; A27-B5-C30; A27-B5-C63; A28-B5-C28; A26-B5-C33; A26-B5-C66; A27-B5-C31; A27-B5-C64; A28-B5-C29; A26-B5-C34; A26-B5-C67; A27-B5-C32; A27-B5-C65; A28-B5-C30; A26-B5-C35; A26-B5-C68; A27-B5-C33; A27-B5-C66; A28-B5-C31; A26-B5-C36; A27-B5-C1; A27-B5-C34; A27-B5-C67; A28-B5-C32; A26-B5-C37; A27-B5-C2; A27-B5-C35; A27-B5-C68; A28-B5-C33; A26-B5-C38; A27-B5-C3; A27-B5-C36; A28-B5-C1; A28-B5-C34; A26-B5-C39; A27-B5-C4; A27-B5-C37; A28-B5-C2; A28-B5-C35; A26-B5-C40; A27-B5-C5; A27-B5-C38; A28-B5-C3; A28-B5-C36; A26-B5-C4J; A27-B5-C6; A27-B5-C39; A28-B5-C4; A28-B5-C37; A26-B5-C42; A27-B5-C7; A27-B5-C40; A28-B5-C5; A28-B5-C38;

• φ * · •

-165 • · · φ φ φ φφφ φφφφΦΦΦΦφφφφφφ

A28-B5-C39;

A28-B5-C40;

A28-B5-C41;

A28-B5-C42;

A28-B5-C43;

A28-B5-C44;

A28-B5-C45;

A28-B5-C46;

A28-B5-C47;

A28-B5-C48;

A28-B5-C49;

A28-B5-C50;

A28-B5-C51;

A28-B5-C52;

A28-B5-C53;

A28-B5-C54;

A28-B5-C55;

A28-B5-C56;

A28-B5-C57;

A28-B5-C58;

A28-B5-C59;

A28-B5-C60;

A28-B5-C61;

A28-B5-C62;

A28-B5-C63;

A28-B5-C64;

A28-B5-C65;

A28-B5-C66;

A28-B5-C67;

A28-B5-C68;

A29-B5-C1;

A29-B5-C2;

A29-B5-C3;

A29-B5-C4;

A29-B5-C5;

A29-B5-C6;

A29-B5-C7;

A29-B5-C8;

A29-B5-C9;

A29-B5-C10;

A29-B5-C11;

A29-B5-C12;

A29-B5-C13;

A29-B5-C14;

A29-B5-C15;

A29-B5-C16;

A29-B5-C17;

A29-B5-C18;

A29-B5-C19;

A29-B5-C20;

A29-B5-C21;

A29-B5-C22;

A29-B5-C23;

A29-B5-C24;

A29-B5-C25;

A29-B5-C26;

A29-B5-C27;

A29-B5-C28;

A29-B5-C29;

A29-B5-C30;

A29-B5-C31;

A29-B5-C32;

A29-B5-C33;

A29-B5-C34;

A29-B5-C3S;

A29-B5-C36;

A29-B5-C37;

A29-B5-C38;

A29-B5-C39;

A29-B5-C40;

A29-B5-C41;

A29-B5-C42;

A29-B5-C43;

A29-B5-C44;

A29-B5-C45;

A29-B5-C46;

A29-B5-C47;

A29-B5-C48;

A29-B5-C49;

A29-B5-C50;

A29-B5-C51;

A29-B5-C52;

A29-B5-C53;

A29-B5-C54;

A29-B5-C55;

A29-B5-C56;

A29-B5-C57;

A29-B5-C58;

A29-B5-C59;

A29-B5-C60;

A29-B5-C61;

A29-B5-C62;

A29-B5-C63;

A29-B5-C64;

A29-B5-C65;

A29-B5-C66;

A29-B5-C67;

A29-B5-C68;

A30-B5-C1;

A30-B5-C2;

A30-B5-C3;

A30-B5-C4;

A30-B5-C5;

A30-B5-C6;

A30-B5-C7;

A30-B5-C8;

A30-BS-C9;

A30-B5-C10;

A30-B5-C11;

A30-B5-C12;

A30-B5-C13;

A30-B5-C14;

A30-B5-C15;

A30-B5-C16;

A30-B5-C17;

A30-B5-C18;

A30-B5-C19;

A30-B5-C20;

A30-B5-C21;

A30-B5-C22;

A30-B5-C23;

A30-B5-C24;

A30-B5-C25;

A30-B5-C26;

A30-B5-C27;

A30-B5-C28;

A30-B5-C29;

A30-B5-C30;

A30-B5-C31;

A30-B5-C32;

A30-B5-C33;

A30-B5-C34;

A30-B5-C35;

A30-B5-C36;

A30-B5-C37;

A30-B5-C38;

A30-B5-C39;

A30-B5-C40;

A30-B5-C41;

A30-B5-C42;

A30-B5-C43;

A30-B5-C44;

A30-B5-C45;

A30-B5-C46;

A30-B5-C47;

A30-B5-C48;

A30-B5-C49;

A30-B5-C50;

A30-B5-C51;

A30-B5-C52;

A30-B5-C53;

A30-B5-C54;

A30-B5-C55;

A30-B5-C55;

A30-B5-C57;

A30-B5-C58;

A30-B5-C59;

A30-B5-C60;

A30-B5-C61;

A30-B5-C62;

A30-B5-C63;

A30-B5-C64;

A30-B5-C65;

A30-B5-C66;

A30-B5-C67;

• · · · · · · · · · · · · · · · · ·

-166A30-B5-C68;

A31-B5-C1;

A31-B5-C2;

A31-B5-C3;

A31-B5-C4;

A31-B5-C5;

A31-B5-C6;

A31-B5-C7;

A31-B5-C8;

A31-B5-C9;

A31-B5-C10;

A31-B5-C11;

A31-B5-C12;

A31-B5-C13;

A31-B5-C14;

A31-B5-C15;

A31-B5-C16;

A31-B5-C17;

A31-B5-C18;

A31-B5-C19;

A31-B5-C20;

A31-B5-C21;

A31-B5-C22;

A31-B5-C23;

A31-B5-C24;

A31-B5-C25;

A31-B5-C26;

A31-B5-C27;

A31-B5-C28;

A31-B5-C29;

A31-B5-C30;

A31-B5-C31;

A31-B5-C32;

A31-B5-C33;

A31-B5-C34;

A31-B5-C35;

A31-B5-C36;

A31-B5-C37;

A31-B5-C38;

A31-B5-C39;

A31-B5-C40;

A31-B5-C41;

A31-B5-C42;

A31-B5-C43;

A31-B5-C44;

A31-B5-C45;

A31-B5-C46;

A31-B5-C47;

A31-B5-C48;

A31-B5-C49;

A31-B5-C50;

A31-B5-C51;

A31-B5-C52;

A31-B5-C53;

A31-B5-C54;

A31-B5-C55;

A31-B5-C56;

A31-B5-C57;

A31-B5-C58;

A31-B5-C59;

A31-B5-C60;

A31-B5-C61;

A31-B5-C62;

A31-B5-C63;

A31-B5-C64;

A31-B5-C65;

A31-B5-C66;

A31-B5-C67;

A31-B5-C68;

A32-B5-C1;

A32-B5-C2;

A32-B5-C3;

A32-B5-C4;

A32-B5-C5;

A32-B5-C6;

A32-B5-C7;

A32-B5-C8;

A32-B5-C9;

A32-B5-C10;

A32-B5-C11;

A32-B5-C12;

A32-B5-C13;

A32-B5-C14;

A32-B5-C15;

A32-B5-C16;

A32-B5-C17;

A32-B5-C18;

A32-B5-C19;

A32-B5-C20;

A32-B5-C21;

A32-B5-C22;

A32-B5-C23;

A32-B5-C24;

A32-B5-C25;

A32-B5-C26;

A32-B5-C27;

A32-B5-C28;

A32-B5-C29;

A32-B5-C30;

A32-B5-C31;

A32-B5-C32;

A32-B5-C33;

A32-B5-C34;

A32-B5-C35;

A32-B5-C36;

A32-B5-C37;

A32-B5-C38;

A32-B5-C39;

A32-B5-C40;

A32-B5-C41;

A32-B5-C42;

A32-B5-C43;

A32-B5-C44;

A32-B5-C45;

A32-B5-C46;

A32-B5-C47;

A32-B5-C48;

A32-B5-C49;

A32-B5-C50;

A32-B5-C51;

A32-B5-C52;

A32-B5-C53;

A32-B5-C54;

A32-B5-C55;

A32-B5-C56;

A32-B5-C57;

A32-B5-C58;

A32-B5-C59;

A32-B5-C60;

A32-B5-C61;

A32-B5-C62;

A32-B5-C63;

A32-B5-C64;

A32-B5-C65;

A32-B5-C66;

A32-B5-C67;

A32-B5-C68;

A33-B5-C1;

A33-B5-C2;

A33-B5-C3;

A33-B5-C4;

A33-B5-C5;

A33-B5-C6;

A33-B5-C7;

A33-B5-C8;

A33-B5-C9;

A33-B5-C10;

A33-B5-C11;

A33-B5-C12;

A33-B5-C13;

A33-B5-C14;

A33rB5-C15;

A33-B5-C16;

Α33-Β5Ό7;

A33-B5-C18;

A33-B5-C19;

A33-B5-C20;

A33-B5-C21;

A33-B5-C22;

A33-B5-C23;

A33-B5-C24;

A33-B5-C25;

A33-B5-C26;

A33-B5-C27;

A33-B5-C28;

- 167 • · · ·

A33-B5-C29;

A33-B5-C30;

A33-B5-C31;

A33-B5-C32;

A33-B5-C33;

A33-B5-C34;

A33-B5-C35;

A33-B5-C36;

A33-B5-C37;

A33-B5-C38;

A33-B5-C39;

A33-B5-C40;

A33-B5-C41;

A33-B5-C42;

A33-B5-C43;

A33-B5-C44;

A33-B5-C45;

A33-B5-C46;

A33-B5-C47;

A33-B5-C48;

A33-B5-C49;

A33-B5-C50;

A33-B5-C51;

A33-B5-C52;

A33-B5-C53;

A33-B5-C54;

A33-B5-C55;

A33-B5-C56;

A33-B5-C57;

A33-B5-C58;

A33-B5-C59;

A33-B5-C60;

A33-B5-C61;

A33-B5-C62;

A33-B5-C63;

A33-B5-C64;

A33-B5-C65;

A33-B5-C66;

A33-B5-C67;

A33-B5-C68;

A34-B5-C1;

A34-B5-C2;

A34-B5-C3;

A34-B5-C4;

A34-B5-C5;

A34-B5-C6;

A34-B5-C7;

A34-B5-C8;

A34-B5-C9;

A34-B5-C10;

A34-B5-C11;

A34-B5-C12;

A34-B5-C13;

A34-B5-C14;

A34-B5-C15;

A34-B5-C16;

A34-B5-C17;

A34-B5-C18;

A34-B5-C19;

A34-B5-C20;

A34-B5-C21;

A34-B5-C22;

A34-B5-C23;

A34-B5-C24;

A34-B5-C25;

A34-B5-C26;

A34-B5-C27;

A34-B5-C28;

A34-B5-C29;

A34-B5-C30;

A34-B5-C31;

A34-B5-C32;

A34-B5-C33;

A34-B5-C34;

A34-B5-C35;

A34-B5-C36;

A34-B5-C37;

A34-B5-C38;

A34-B5-C39;

A34-B5-C40;

A34-B5-C41;

A34-B5-C42;

A34-B5-C43;

A34-B5-C44;

A34-B5-C45;

A34-B5-C46;

A34-B5-C47;

A34-B5-C48;

A34-B5-C49;

A34-B5-C50;

A34-B5-C51;

A34-B5-C52;

A34-B5-C53;

A34-B5-C54;

A34-B5-C55;

A34-B5-C56;

A34-B5-C57;

A34-B5-C58;

A34-B5-C59;

A34-B5-C60;

A34-B5-C61;

A34-B5-C62;

A34-B5-C63;

A34-B5-C64;

A34-B5-C65;

A34-B5-C66;

A34-B5-C67;

A34-B5-C68;

A35-B5-C1;

A35-B5-C2;

A35-B5-C3;

A35-B5-C4;

A35-B5-C5;

A35-B5-C6;

A35-B5-C7;

A35-B5-C8;

A35-B5-C9;

A35-B5-C10;

A35-B5-C11;

A35-B5-C12;

A35-B5-C13;

A35-B5-C14;

A35-B5-C15;

A35-B5-C16;

A35-B5-C17;

A35-B5-C18;

A35-B5-C19;

A35-B5-C20;

A35-B5-C21;

A35-B5-C22;

A35-B5-C23;

A35-B5-C24;

A35-B5-C25;

A35-B5-C26;

A35-B5-C27;

A35-B5-C28;

A35-B5-C29;

A35-B5-C30;

A35-B5-C31;

A35-B5-C32;

A35-B5-C33;

A35-B5-C34;

A35-B5-C35;

A35-B5-C36;

A35-B5-C37;

A35-B5-C38;

A35-B5-C39;

A35-B5-C40;

A35-B5-C41;

A35-B5-C42;

A35-B5-C43;

A35-B5-C44;

A35-B5-C45;

A35-B5-C46;

A35-B5-C47;

A35-B5-C48;

A35-B5-C49;

A35-B5-C50;

A35-B5-C51;

A35-B5-C52;

A35-B5-C53;

A35-B5-C54;

A35-B5-C55;

A35-B5-C56;

A35-B5-C57;

-168-

A35-B5-C58;

A35-B5-C59;

A35-B5-C60;

A35-B5-C61;

A35-B5-C62;

A35-B5-C63;

A35-B5-C64;

A35-B5-C65;

A35-B5-C66;

A35-B5-C67;

A35-B5-C68;

A36-B5-C1;

A36-B5-C2;

A36-B5-C3;

A36-B5-C4;

A36-B5-C5;

A36-B5-C6;

A36-B5-C7;

A36-B5-C8;

A36-B5-C9;

A36-B5-C10;

A36-B5-C11;

A36-B5-C12;

A36-B5-C13;

A36-B5-C14;

A36-B5-C15;

A36-B5-C16;

A36-B5-C17;

A36-B5-C18;

A36-B5-C19;

A36-B5-C20;

A36-B5-C21;

A36-B5-C22;

A36-B5-C23;

A36-B5-C24;

A36-B5-C25;

A36-B5-C26;

A36-B5-C27;

A36-B5-C28;

A36-B5-C29;

A36-B5-C30;

A36-B5-C31;

A36-B5-C32;

A36-B5-C33;

A36-B5-C34;

A36-B5-C35;

A36-BS-C36;

A36 - BS - C37;

A36-B5-C38;

A36-B5-C39;

A36-B5-C40;

A36-B5-C41;

A36-B5-C42;

A36-B5-C43;

A36-B5-C44;

A36-B5-C45;

A36-B5-C46;

A36-B5-C47;

A36-B5-C48;

A36-B5-C49;

A36-B5-C50;

A36-B5-C51;

A36-B5-C52;

A36-B5-C53;

A36-B5-C54;

A36-B5-C55;

A36-B5-C56;

A36-B5-C57;

A36-B5-C58;

A36-B5-C59;

A36-B5-C60;

A36-B5-C61;

A36-B5-C62;

A36-B5-C63;

A36-B5-C64;

A36-B5-C65;

A36-B5-C66;

A36-B5-C67;

A36-B5-C68;

A37-B5-C1;

A37-B5-C2;

A37-B5-C3;

A37-B5-C4;

A37-B5-C5;

A37-B5-C6;

A37-B5-C7;

A37-B5-C8;

A37-B5-C9;

A37-B5-C10;

A37-B5-C11;

A37-B5-C12;

A37-B5-C13;

A37-B5-C14;

A37-B5-C15;

A37-B5-C16;

A37-B5-C17;

A37-B5-C18;

A37-B5-C19;

A37-B5-C20;

A37-BS-C21;

A37-B5-C22;

A37-B5-C23;

A37-B5-C24;

A37-B5-C25;

A37-B5-C26;

A37-B5-C27;

A37-B5-C28;

A37-B5-C29;

A37-B5-C30;

A37-B5-C31;

A37-B5-C32;

A37-B5-C33;

A37-B5-C34;

A37-B5-C35;

A37-B5-C36;

A37-B5-C37;

A37-B5-C38;

A37-B5-C39;

A37-B5-C40;

A37-B5-C41;

A37-B5-C42;

A37-B5-C43;

A37-B5-C44;

A37-B5-C45;

A37-B5-C46;

A37-B5-C47;

A37-B5-C48;

A37-B5-C49;

A37-B5-C50;

A37-B5-C51;

A37-B5-C52;

A37-B5-C53;

A37-B5-C54;

A37-B5-C55;

A37-B5-C56;

A37-B5-C57;

A37-B5-C58;

A37-B5-C59;

A37-B5-C60;

A37-B5-C61;

A37-B5-C62;

A37-B5-C63;

A37-B5-C64;

A37-B5-C65;

A37-B5-C66;

A37-B5-C67;

A37-BS-C68;

A38-B5-C1;

A38-B5-C2;

A38-B5-C3;

A38-B5-C4;

A38-B5-C5;

A38-B5-C6;

A38-B5-C7;

A38-B5-C8;

A38-B5-C9;

A38-B5-C10;

A38-B5-C11;

A38-B5-C12;

A38-B5-C13;

A38-B5-C14;

A38-B5-C15;

A38-B5-C16;

A38-B5-C17;

A38-B5-C18;

• ·

- 169-

A38-B5-C19;

A38-B5-C20;

A38-B5-C21;

A38-B5-C22;

A38-B5-C23;

A38-B5-C24;

A38-B5-C25;

A38-B5-C26;

A38-B5-C27;

A38-B5-C28;

A38-B5-C29;

A38-B5-C30;

A38-B5-C31;

A38-B5-C32;

A38-B5-C33;

A38-B5-C34;

A38-B5-C35;

A38-B5-C36;

A38-B5-C37;

A38-B5-C38;

A38-B5-C39;

A38-B5-C40;

A38-B5-C41;

A38-B5-C42;

A38-B5-C43;

A38-B5-C44;

A38-B51C45;

A38-B5-C46;

A38-B5-C47;

A38-B5-C48;

A38 - BS - C49;

A38-B5-C50;

A38-B5-C51;

A38-B5-C52;

A38-B5-C53;

A38-B5-C54;

A38-B5-C55;

A38-B5-C56;

A38-B5-C57;

A38-B5-C58;

A38-B5-C59;

A38-B5-C60;

A38-B5-C61;

A38-B5-C62;

A38-B5-C63;

A38-B5-C64;

A38-B5-C65;

A38-B5-C66;

A38-B5-C67;

A3S-B5-C68;

A1-B6-C1;

A1-B6-C2;

A1-B6-C3;

A1-B6-C4;

A1-B6-C5;

A1-B6-C6;

A1-B6-C7;

A1-B6-C8;

A1-B6-C9;

A1-B6-C10;

A1-B6-C11;

A1-B6-C12;

A1-B6-C13;

A1-B6-C14;

A1-B6-C15;

A1-B6-C16;

A1-B6-C17;

A1-B6-C18;

A1-B6-C19;

A1-B6-C20;

A1-B6-C21;

A1-B6-C22;

A1-B6-C23;

A1-B6-C24;

A1-B6-C25;

A1-B6-C26;

A1-B6-C27;

A1-B6-C28;

A1-B6-C29;

A1-B6-C30;

A1-B6-C31;

A1-B6-C32;

A1-B6-C33;

A1-B6-C34;

A1-B6-C35;

A1-B6-C36;

A1-B6-C37;

A1-B6-C38;

A1-B6-C39;

A1-B6-C40;

A1-B6-C41;

A1-B6-C42;

A1-B6-C43;

A1-B6-C44;

A1-B6-C45;

A1-B6-C46;

A1-B6-C47;

A1-B6-C48;

A1-B6-C49;

A1-B6-C50;

A1-B6-C51;

A1-B6-C52;

A1-B6-C53;

A1-B6-C54;

A1-B6-C55;

A1-B6-C56;

A1-B6-C57;

A1-B6-C58;

A1-B6-C59:

A1-B6-C60;

A1-B6-C61;

A1-B6-C62;

A1-B6-C63;

A1-B6-C64;

A1-B6-C65;

A1-B6-C66;

A1-B6-C67;

A1-B6-C68;

A2-B6-C1;

A2-B6-C2;

A2-B6-C3;

A2-B6-C4;

A2-B6-C5;

A2-B6-C6;

A2-B6-C7;

A2-B6-C8;

A2-B6-C9;

A2-B6-C10;

A2-B6-C11;

A2-B6-C12;

A2-B6-C13;

A2-B6-C14;

A2-B6-C15;

A2-B6-C16;

A2-B6-C17;

A2-B6-C18;

A2-B6-C19;

A2-B6-C20;

A2-B6-C21;

A2-B6-C22;

A2-B6-C23;

A2-B6-C24;

A2-B6-C25;

A2-B6-C26;

A2-B6-C27;

A2-B6-C28;

A2-B6-C29;

A2-B6-C30;

A2-B6-C31;

A2-B6-C32;

A2-B6-C33;

A2-B6-C34;

A2-B6-C35;

A2-B6-C36;

A2-B6-C37;

A2-B6-C38;

A2-B6-C39;

A2-B6-C40;

A2-B6-C41;

A2-B6-C42;

A2-B6-C43;

A2-B6-C44;

A2-B6-C45;

A2-B6-C46;

A2-B6-C47;

tftf · tff tff tff tff

-170 «• tf tftf tftf ··· tftf

A2-B6-C48; A3-B6-C13; A3-B6-C46; A4-B6-C11; A4-B6-C44; A2-B6-C49; A3-B6-C14; A3-B6-C47; A4-B6-C12; A4-B6-C45; A2-B6-C50; A3-B6-C15; A3-B6-C48; A4-B6-C13; A4-B6-C46; A2-B6-C51; A3-B6-C16; A3-B6-C49; A4-B6-C14; A4-B6-C47; A2-B6-C52; A3-B6-C17; A3-B6-C50; A4-B6-C15; A4-B6-C48; A2-B6-C53; A3-B6-C18; A3-B6-CS2; A4-B6-C16; A4-B6-C49; A2-B6-C54; A3-B6-C19; A3-B6-C52; A4-B6-C17; A4-B6-C50; A2-B6-C55; A3-B6-C20; A3-B6-C53; A4-B6-C18; A4-B6-C51; A2-B6-C56; A3-B6-C21; A3-B6-C54; A4-B6-C19; A4-B6-C52; A2-B6-C57; A3-B6-C22; A3-B6-C55; A4-B6-C20; A4-B6-C53; A2-B6-C58; A3-B6-C23; A3-B6-C55; A4-B6-C21; A4-B6-C54; A2-B6-C59; A3-B6-C24; A3-B6-C57; A4-B6-C22; A4-B6-C55; A2-B6-C60; A3-B6-C25; A3-B6-C58; A4-B6-C23; A4-B6-C55; A2-B6-C61; A3-B6-C26; A3-B6-C59; A4-B6-C24; A4-B6-C57; A2-B6-C62; A3-B6-C27; A3-B6-C60; A4-B6-C25; A4-B6-C58; A2-B6-C63; A3-B6-C28; A3-B6-C61; A4-B6-C26; A4-B6-C59; A2-B6-C64; A3-B6-C29; A3-B6-C62; A4-B6-C27; A4-B6-C60; A2-B6-C65; A3-B6-C30; A3-B6-C63; A4-B6-C28; A4-B6-C61; A2-B6-C66; A3-B6-C31; A3-B6-C64; A4-B6-C29; A4-B6-C62; A2-B6-C67; A3-B6-C32; A3-B6-C65; A4-B6-C30; A4-B6-C63; A2-B6-C68; A3-B6-C33; A3-B6-C66; A4-B6-C31; A4-B6-C64; A3-B6-C1; A3-B6-C34; A3-B6-C67; A4-B6-C32; A4-B6-C65; A3-B6-C2; A3-B6-C35; A3-B6-C68; A4-B6-C33; A4-B6-C66; A3-B6-C3; A3-B6-C36; A4-B6-C1; A4-B6-C34; A4-B6-C67; A3-B6-C4; A3-B6-C37; A4-B6-C2; A4-B6-C35; A4-B6-C68; A3-B6-C5; A3-B6-C38; A4-B6-C3; A4-B6-C36; A5-B6-C1; A3-B6-C6; A3-B6-C39; A4-B6-C4; A4-B6-C37; A5-B6-C2; A3-B6-C7; A3-B6-C40; A4-B6-C5; A4-B6-C38; A5-B6-C3; A3-B6-C8; A3-B6-C41; A4-B6-C6; A4-B6-C39; A5-B6-C4; A3-B6-C9; A3-B6-C42; A4-B6-C7; A4-B6-C40; A5-B6-C5; A3-B6-C10; A3-B6-C43; A4-B6-C8; A4-B6-C41; A5-B6-C6; A3-B6-C11; A3-B6-C44; A4-B6-C9; A4-B6-C42; A5-B6-C7; A3-B6-C12; A3-B6-C45; A4-B6-C10; A4-B6-C43; A5-B6-C8;

-171-

A5-B6-C9;

A5-B6-C10;

A5-B6-C11;

A5-B6-C12;

A5-B6-C13;

A5-B6-C14;

A5-B6-C15;

A5-B6-C16;

A5-B6-C17;

A5-B6-C18;

A5-B6-C19;

A5-B6-C20;

A5-B6-C21;

A5-B6-C22;

A5-B6-C23;

A5-B6-C24;

A5-B6-C25;

A5-B6-C26;

A5-B6-C27;

A5-B6-C28;

A5-B6-C29;

A5-B6-C30;

A5-B6-C31;

A5-B6-C32;

A5-B6-C33;

A5-B6-C34;

A5-B6-JC35;

AS-B6-C36;

A5-B6-C37;

A5-B6-C38;

A5-B6-C39;

A5-B6-C40;

A5-B6-C41;

A5-B6-C42;

A5-B6-C43;

A5-B6-C44;

AS-B6-C45;

A5-B6-C46;

A5-B6-C47;

A5-B6-C48;

A5-B6-C49;

A5-B6-C50;

A5-B6-C51;

A5-B6-C52;

A5-B6-C53;

A5-B6-C54;

A5-B6-C55;

A5-B6-C56;

A5-B6-C57;

A5-B6-C58;

A5-B6-C59;

A5-B6-C60;

A5-B6-C61;

A5-B6-C62;

A5-B6-C63;

A5-B6-C64;

A5-B6-C65;

A5-B6-C66;

A5-B6-C67;

A5-B6-C68;

A6-B6-C1;

A6-B6-C2;

A6-B6-C3;

A6-B6-C4;

A6-B6-C5;

A6-B6-C6;

A6-B6-C7;

A6-B6-C8;

A6-B6-C9;

A6-B6-C10;

A6-B6-C11;

A6-B6-C12;

A6-B6-C13;

A6-B6-C14;

A6-B6-C15;

A6-B6-C16;

A6-B6-C17;

A6-B6-C18;

A6-B6-C19;

A6-B6-C20;

A6-B6-C21;

A6-B6-C22;

A6-B6-C23;

A6-B6-C24;

A6-B6-C25;

A6-B6-C26;

A6-B6-C27;

A6-B6-C28;

A6-B6-C29;

A6-B6-C30;

A6-B6-C31;

A6-B6-C32;

A6-B6-C33;

A6-B6-C34;

A6-B6-C35;

A6-B6-C36;

A6-B6-C37;

A6-B6-C38;

A6-B6-C39;

A6-B6-C40;

A6-B6-C41;

A6-B6-C42;

A6-B6-C43;

A6-B6-C44;

A6-B6-C45;

A6-B6-C46;

A6-B6-C47;

A6-B6-C48;

A6-B6-C49;

A6-B6-C50;

A6-B6-C51;

A6-B6-C52;

A6-B6-C53;

A6-B6-C54;

A6-B6-C55;

A6-B6-C55;

A6-B6-C57;

A6-B6-C58;

A6-B6-C59;

A6-B6-C60;

A6-B6-C61;

A6-B6-C62;

A6-B6-C63;

A6-B6-C64;

A6-B6-C65;

A6-B6-C66;

A6-B6-C67;

A6-B6-C68;

A7-B6-C1;

A7-B6-C2;

A7-B6-C3;

A7-B6-C4;

A7-B6-C5;

A7-B6-C6;

A7-B6-C7;

A7-B6-C8;

A7-B6-C9;

A7-B6-C10;

A7-B6-C11;

A7-B6-C12;

A7-B6-C13;

A7-B6-C14;

A7-B6-C15;

A7-B6-C16;

A7-B6-C17;

A7-B6-C18;

A7-B6-C19;

A7-B6-C20;

A7-B6-C21;

A7-B6-C22;

A7-B6-C23;

A7-B6-C24;

A7-B6-C25;

A7-B6-C26;

A7-B6-C27;

A7-B6-C28;

A7-B6-C29;

A7-B6-C30;

A7-B6-C31;

A7-B6-C32;

A7-B6-C33;

A7-B6-C34;

A7-B6-C35;

A7-B6-C36;

A7-B6-C37;

Φ ·

-172 ·· ···

A7-B6-C38;

A7-B6-C39;

A7-B6-C40;

A7-B6-C41;

A7-B6-C42;

A7-B6-C43;

A7-B6-C44;

A7-B6-C45;

A7-B6-C46;

A7-B6-C47;

A7-B6-C48;

A7-B6-C49;

A7-B6-C50;

A7-B6-C51;

A7-B6-C52;

A7-B6-C53;

A7-B6-C54;

A7-B6-C55;

A7-B6-C56;

A7-B6-C57;

A7-B6-C58;

A7-B6-C59;

A7-B6-C60;

A7-B6-C61;

A7-B6-C62;

A7-B6-C63;

A7-B6-C64;

A7-B6-C65;

A7-B6-C66;

A7-B6-C67;

A7-B6-C68;

A8-B6-C1;

A8-B6-C2;

A8-B6-C3;

A8-B6-C4;

A8-B6-C5;

A8-B6-C6;

A8-B6-C7;

A8-B6-C8;

A8-B6-C9;

A8-B6-C10;

A8-B6-C11;

A8-B6-C12;

A8-B6-C13;

A8-B6-C14;

A8-B6-C15;

A8-B6-C16;

A8-B6-C17;

A8-B6-C18;

A8-B6-C19;

A8-B6-C20;

A8-B6-C21;

A8-B6-C22;

A8-B6-C23;

A8-B6-C24;

A8-B6-C25;

A8-B6-C26;

A8-B6-C27;

A8-B6-C28;

A8-B6-C29;

A8-B6-C30;

A8-B6-C31;

A8-B6-C32;

A8-B6-C33;

A8-B6-C34;

A8-B6-C35;

A8-B6-C36;

A8-B6-C37;

A8-B6-C38;

A8-B6-C39;

A8-B6-C40;

A8-B6-C41;

A8-B6-C42;

A8-B6-C43;

A8-B6-C44;

A8-B6-C45;

A8-B6-C46;

A8-B6-C47;

A8-B6-C48;

A8-B6-C49;

A8-B6-C50;

A8-B6-C51;

A8-B6-C52;

A8-B6-C53;

A8-B6-C54;

A8-B6-C55;

A8-B6-C56;

A8-B6-C57;

A8-B6-C5S;

A8-B6-C59;

A8-B6-C60;

A8-B6-C61;

A8-B6-C62;

A8-B6-C63;

A8-B6-C64;

A8-B6-C65;

A8-B6-C66;

A8-B6-C67;

A8-B6-C68;

A9-B6-C1;

A9-B6-C2;

A9-B6-C3;

A9-B6-C4;

A9-B6-C5;

A9-B6-C6;

A9-B6-C7;

A9-B6-C8;

A9-B6-C9;

A9-B6-C10;

A9-B6-C11;

A9-B6-C12;

A9-B6-C13;

A9-B6-C14;

A9-B6-C15;

A9-B6-C16;

A9-B6-C17;

A9-B6-C18;

A9-B6-C19;

A9-B6-C20;

A9-B6-C21;

A9-B6-C22;

A9-B6-C23;

A9-B6-C24;

A9-B6-C25;

A9-B6-C26;

A9-B6-C27;

A9-B6-C28;

A9-B6-C29;

A9-B6-C30;

99-B6-C31;

A9-B6-C32;

A9-B6-C33;

A9-B6-C34;

99-B6-C35;

A9-B6-C36;

A9-B6-C37;

A9-B6-C38;

A9-B6-C39;

A9-B6-C40;

A9-B6-C41;

A9-B6-C42;

A9-B6-C43;

A9-B6-C44;

A9-B6-C45;

A9-B6-C46;

99-B6-C47;

99-B6-C48;

99-B6-C49;

A9-B6-C50;

99-B6-C51;

A9-B6-C52;

A9-B6-C53;

A9-B6-C54;

A9-B6-C55;

99-B6-C56;

A9-B6-C57;

99-B6-C58;

A9-B6-C59;

A9-B6-C60;

A9-B6-C61;

A9-B6-C62;

A9-B6-C63;

A9-B6-C64;

A9-B6-C65;

A9-B6-C66;

-173-

·· ·· *

A9-B6-C67;

A9-B6-C68;

A10-B6-C1;

A10-B6-C2;

A10-B6-C3;

A10-B6-C4;

A10-B6-C5;

A10-B6-C6;

A10-B6-C7;

A10-B6-C8;

A10-B6-C9;

A10-B6-C10;

A10-B6-C11;

A10-B6-C12;

A10-B6-C13;

A10-B6-C14;

A10-B6-C15;

A10-B6-C16;

A10-B6-C17;

A10-B6-C18;

A10-B6-C19;

A10-B6-C20;

A10-B6-C21;

A10-B6-C22;

A10-B6-C23;

A10-B6-C24;

A10-B6-C25;

A10-B6-C26;

A10-B6-C27;

A10-B6-C28;

A10-B6-C29;

A10-B6-C30;

A10-B0-C31;

A10-B6-C32;

A10-B6-C33;

A10-B6-C34;

A10-B6-C35;

A10-B6-C36;

A10-B6-C37;

A10-B6-C38;

A10-B6-C39;

A10-B6-C40;

A10-B6-C41;

A10-B6-C42;

A10-B6-C43;

A10-B6-C44;

A10-B6-C45;

A10-B6-C46;

A10-B6-C47;

A10-B6-C48;

A10-B6-C49;

A10-B6-C50;

A10-B6-C51;

A10-B6-C52;

A10-B6-C53;

A10-B6-C54;

A10-B6-C55;

A10-B6-CS6;

A10-B6-C57;

A10-B6-C58;

A10-B6-C59;

A10-B6-C60;

A10-B6-C61;

A10-B6-C62;

A10-B6-C63;

A10-B6-C64;

A10-B6-C65;

A10-B6-C66;

A10-B6-C67;

A10-B6-C68;

A11-B6-C1;

A11-B6-C2;

A11-B6-C3;

A11-B6-C4;

A11-B6-C5;

A11-B6-C6;

A11-B6-C7;

A11-B6-C8;

A11-B6-C9;

A11-B6-C10;

A11-B6-C11;

A11-B6-C12;

A11-B6-C13;

A11-B6-C14;

A11-B6-C15;

A11-B6-C16;

A11-B6-C17;

A11-B6-C18;

A11-B6-C19;

A11-B6-C20;

A11-B6-C21;

A11-B6-C22;

A11-B6-C23;

A11-B6-C24;

A11-B6-C25;

A11-B6-C26;

A11-B6-C27;

A11-B6-C28;

A11-B6-C29;

A11-B6-C30;

A11-B6-C31;

A11-B0-C32;

A11-B6-C33;

A11-B6-C34;

A11-B6-C35;

A11-B6-C36;

A11-B6-C37;

A11-B6-C38;

A11-B6-C39;

A11-B6-C40;

A11-B6-C41;

A11-B6-C42;

A11-B6-C43;

A11-B6-C44;

A11-B6-C45;

A11-B6-C46;

A11-B6-C47;

A11-B6-C48;

A11-B6-C49;

A11-B6-CS0;

A11-B6-C51;

A11-B6-CS2;

A11-B6-C53;

A11-B6-C54;

A11-B6-C55;

A11-B6-C56;

A11-B6-C57;

Al1-B6-C58;

A11-B6-C59;

A11-B6-C60;

A11-B6-C61;

A11-B6-C62;

A11-B6-C63;

A11-B6-C64;

A11-B6-C65;

Al1-B6-C66;

A11-B6-C67;

A11-B6-C68;

A12-B6-C1;

A12-B6-C2;

A12-B6-C3;

A12-B6-C4;

A12-B6-C5;

A12-B6-C6;

A12-B6-C7;

A12-B6-C8;

A12-B6-C9;

Al2-B6-C10;

A12-B6-C11;

A12-B6-C12;

A12-B6-C13;

A12-B0-C14;

A12-B6-C15;

A12-B6-C16;

A12-B6-C17;

A12-B6-C18;

A12-B6-C19;

A12-B6-C20;

A12-B6-C21;

A12-B6-C22;

A12-B6-C23;

A12-B6-C24;

A12-B6-C25;

A12-B6-C26;

A12-B6-C27;

44 44 44

4 4 4 4 43 4

43 4 4 4 4

- 1745 4 4 4 4 4 4

444 44 44

A12-B6-C28;

A12-B6-C29;

A12-B6-C30;

A12-B6-C31;

A12-B6-C32;

A12-B6-C33;

A12-B6-C34;

A12-B6-C35;

A12-B6-C36;

A12-B6-C37;

A12-B6-C38;

A12-B6-C39;

A12-B6-C40;

A12-B6-C41;

A12-B6-C42;

A12-B6-C43;

A12-B6-C44;

A12-B6-C45;

A12-B6-C46;

A12-B6-C47;

A12-B6-C48;

A12-B6-C49;

A12-B6-C50;

A12-B6-C51;

A12-B6-C52;

A12-B6-C53;

A12-B6-C54;

A12-B6-C55;

A12-B6-C56;

A12-B6-C57;

A12-B6-C58;

A12-B6-C59;

A12-B6-C60;

A12-B6-C61;

A12-B6-C62;

A12-B6-C63;

A12-B6-C64;

A12-B6-C65;

A12-B6-C66;

A12-B6-C67;

A12-B6-C68;

A13-B6-C1;

A13-B6-C2;

A13-B6-C3;

A13-B6-C4;

A13-B6-C5;

A13-B6-C6;

A13-B6-C7;

A13-B6-C8;

A13-B6-C9;

A13-B6-C10;

A13-B6-C11;

A13-B6-C12;

A13-B6-C13;

A13-B6-C14;

A13-B6-C15;

A13-B6-C16;

A13-B6-C17;

A13-B6-C18;

A13-B6-C19;

A13-B6-C20;

A13-B6-C21;

A13-B6-C22;

A13-B6-C23;

A13-B6-C24;

A13-B6-C25;

A13-B6-C26;

A13-B6-C27;

A13-B6-C28;

A13-B6-C29;

A13-B6-C30;

A13-B6-C31;

A13-B6-C32;

A13-B6-C33;

A13-B6-C34;

A13-B6-C35;

A13-B6-C36;

A13-B6-C37;

A13-B6-C38;

A13-B6-C39;

A13-B6-C40;

A13-B6-C41;

A13-B6-C42;

A13-B6-C43;

A13-B6-C44;

A13-B6-C45;

A13-B6-C46;

A13-B6-C47;

A13-B6-C48;

A13-B6-C49;

A13-B6-C50;

A13-B6-C51;

A13-B6-C52;

A13-B6-C53;

A13-B6-C54;

A13-B6-C55;

A13-B6-C56;

A13-B6-C57;

A13-B6-C58;

A13-B6-C59;

A13-B6-C60;

A13-B6-C61;

A13-B6-C62;

A13-B6-C63;

A13-B6-C64;

A13-B6-C65;

A13-B6-C66;

A13-B6-C67;

A13-B6-C68;

A14-B6-C1;

A14-B6-C2;

A14-B6-C3;

A14-B6-C4;

A14-B6-C5;

A14-B6-C6;

A14-B6-C7;

A14-B6-C8;

A14-B6-C9;

A14-B6-C10;

A14-B6-C11;

A14-B6-C12;

A14-B6-C13;

A14-B6-C14;

A14-B6-C15;

44-B6-C16;

A14-B6-C17;

A14-B6-C18;

A14-B6-C19;

A14-B6-C20;

A14-B6-C21;

A14-B6-C22;

A14-B6-C23;

A14-B6-C24;

A14-B6-C25;

A14-B6-C26;

A14-B6-C27;

A14-B6-C28;

A14-B6-C29;

A14-B6-C30;

A14-B6-C31;

A14-B6-C32;

A14-B6-C33;

A14-B6-C34;

A14-B6-C35;

A14-B6-C36;

A14-B6-C37;

A14-B6-C38;

A14-B6-C39;

A14-B6-C40;

A14-B6-C41;

A14-B6-C42;

A14-B6-C43;

A14-B6-C44;

A14-B6-C45;

A14-B6-C46;

A14-B6-C47;

A14-B6-C48;

A14-B6-C49;

A14-B6-C50;

A14-B6-C51;

A14-B6-C52;

A14-B6-C53;

A14-B6-C54;

A14-B6-C55;

A14-B6-C56;

175 A14-B6-C57;

A14-B6-C58;

A14-B6-C59;

A14-B6-C60;

A14-B6-C61;

A14-B6-C62;

A14-B6-C63;

A14-B6-C64;

A14-B6-C65;

A14-B6-C66;

A14-B6-C67;

A14-B6-C68;

A15-B6-C1;

A15-B6-C2;

A15-B6-C3;

A15-B6-C4;

A15-B6-C5;

A15-B6-C6;

A15-B6-C7;

A15-B6-C8;

A15-B6-C9;

A15-B6-C10;

A15-B6-C11;

A15-B6-C12;

A15-B6-C13;

A15-B6-C14;

Α15-»6 »· Ο5;

A15-B6-C16;

A15-B6-C17;

A15-B6-C18;

A15-B6-C19;

A15-B6-C20;

A15-B6-C21;

A15-B6-C22;

A15-B6-C23;

A15-B6-C24;

A15-B6-C25;

A15-B6-C26;

A15-B6-C27;

A15-B6-C28;

A15-B6-C29;

A15-B6-C30;

A15-B6-C31;

A15-B6-C32;

A15-B6-C33;

A15-B6-C34;

A15-B6-C35;

A15-B6-C36;

A15-B6-C37;

A15-B6-C38;

A15-B6-C39;

A15-B6-C40;

A15-B6-C41;

A15-B6-C42;

A15-B0-C43;

A15-B6-C44;

A15-B6-C45;

A15-B6-C46;

A15-B6-C47;

A15-B6-C48;

A15-B6-C49;

A15-B6-C50;

A15-B6-C51;

A15-B6-C52;

A15-B6-C53;

A15-B6-C54;

A15-B6-C55;

A15-B6-C56;

A15-B6-C57;

A15-B6-C58;

A15-B6-C59;

A15-B6-C60;

A15-B6-C61;

A15-B6-C62;

A15-B6-C63;

A15-B6-C64;

A15-B6-C65;

A15-B6-C66;

A15-B6-C67;

A15-B6-C68;

A16-B6-C1;

A16-B6-C2;

A16-B6-C3;

A16-B6-C4;

A16-B6-C5;

A16-B6-C6;

A16-B6-C7;

A16-B6-C8;

A16-B6-C9;

Al6-B6-C10;

A16-B6-C11;

A16-B6-C12;

A16-B6-C13;

A16-B6-C14;

A16-B6-C15;

A16-B6-C155

A16-B6-C17;

A16-B6-C18;

A16-B6-C19;

A16-B6-C20;

A16-B6-C21;

A16-B6-C22;

A16-B6-C23;

A16-B6-C24;

A16-B6-C25;

A16-B6-C26;

A16-B6-C27;

A16-B6-C28;

A16-B6-C29;

A16-B6-C30;

A16-B6-C31;

A16-B6-C32;

A16-B6-C33;

A16-B6-C34;

A16-B6-C35;

A16-B6-C36;

A16-B6-C37;

A16-B6-C38;

A16-B6-C39;

A16-B6-C40;

A16-B6-C41;

A16-B6-C42;

A16-B6-C43;

A16-B6-C44;

A16-B6-C45;

A16-B6-C46;

A16-B6-C47;

A16-B6-C48;

A16-B6-C49;

A16-B6-C50;

A16-B6-C51;

A16-B6-C52;

A16-B6-C53;

A16-B6-C54;

A16-B6-C55;

A16-B6-C56;

A16-B6-C57;

A16-B6-C58;

A16-B6-C59;

A16-B6-C60;

A16-B6-C61;

A16-B6-C62;

A16-B6-C63;

A16-B6-C64;

A16-B6-C65;

A16-B6-C66;

A16-B6-C67;

A16-B6-C68;

A17-B6-C1;

A17-B6-C2;

A17-B6-C3;

A17-B6-C4;

A17-B6-C5;

A17-B6-C6;

A17-B6-C7;

A17-B6-C8;

A17-B6-C9;

A17-B6-C10;

A17-B6-C11;

A17-B6-C12;

A17-B6-C13;

A17-B6-C14;

A17-B6-C15;

A17-B0-C16;

A17-B6-C17;

-176-

• · « • · · • · · • φ φ • φφφ φφφ φφ φ φ φ φ φ φ · · φφ φφφ φ φ

AX7-B6-CX7; AX7-B6-C5X; AX8-B6-C16; A18-B6-C49; A19-B6-C14; A17-B6-C19; A17-B6-C52; A18-B6-C17; A18-B6-C50; A19-B6-C15; A17-B6-C20; A17-B6-C53; A18-B6-C18; A18-B6-C51; A19-B6-C16; A17-B6-C21; A17-B6-C54; A18-B6-C19; A18-B6-C52; A19-B6-C17; A17-B6-C22; A17-B6-C55; A18-B6-C20; A18-B6-C53; AX9-B6-CX7; A17-B6-C23; A17-B6-C56; A18-B6-C21; A18-B6-C54; AX9-B6-C19; A17-B6-C24; Al7-B6-C57; A18-B6-C22; A18-B6-C55; A19-B6-C20; AX7-B6-C25; A17-B6-C58; A18-B6-C23; A18-B6-C56; AX9-B6-C2X; A17-B6-C26; A17-B6-C59; A18-B6-C24; A18-B6-C57; AX9-B6-C22; A17-B6-C27; A17-B6-C60; A18-B6-C25; A18-B6-C58; AX9-B6-C23; A17-B6-C28; A17-B6-C61; A18-B6-C26; A18-B6-C59; AX9-B6-C24; AX7-B6-C29; A17-B6-C62; A18-B6-C27; A18-B6-C60; AX9-B6-C25; A17-B6-C30; A17-B6-C63; A18-B6-C28; A18-B6-C61; AX9-B6-C26; AX7-B6-C3X; AX7-B6-C64; A18-B6-C29; A18-B6-C62; A19-B6-C27; A17-B6-C32; A17-B6-C65; A18-B6-C30; AX8-B6-C62; AX9-B6-C28; AX7-B6-C33; AX7-B6-C66; A18-B6-C31; A18-B6-C64; AX9-B6-C29; A17-B6-C34; A17-B6-C67; A18-B6-C32; A18-B6-C65; AX9-B6-C30; A17-B6-C35; AX7-B6-C68; A18-B6-C33; A18-B6-C66; A19-B6-C31; A17-B6-C36; A18-B6-C1; A18-B6-C34; A18-B6-C67; AX9-B6-C33; A17-B6-C37; A18-B6-C2; A18-B6-C35; A18-B6-C68; AX9-B6-C33; A17-B6-C38; A18-B6-C3; A18-B6-C36; A19-B6-C1; A19-B6-C34; A17-B6-C39; A18-B6-C4; A18-B6-C37; A19-B6-C2; AX9-B6-C35; AX7-B6-C40; A18-B6-C5; A18-B6-C38; A19-B6-C3; AX9-B6-C36; A17-B6-C4X; A18-B6-C6; A18-B6-C39; A19-B6-C4; AX9-B6-C37; Al7-B6-C42; A18-B6-C7; A18-B6-C40; A19-B6-C5; A19-B6-C38; A17-B6-C43; A18-B6-C8; A18-B6-C41; AX9-B6-C6; AX9-B6-C39; AX7-B6-C44; A18-B6-C9; A18-B6-C42; A19-B6-C7; AX9-B6-C40; AX7-B6-C45; A18-B6-C10; A18-B6-C43; AX9-B6-C7; A19-B6-C4X; AX7-B6-C46; AX8-B5-CXX; A18-B6-C44; A19-B6-C9; AX9-B6-C41; AX7-B6-C46; A18-B6-CX2; A18-B6-C45; AX9-B6-CX1; A19-B6-C43; AX7-B6-C48; A18-B6-C13; A18-B6-C46; AX9-B5-CXX; AX9-B6-C44; A17-B6-C49; AX8-B6-C14; A18-B6-C47; A19-B6-C12; A19-B6-C45; A17-B6-C50; A18-B6-C15; A18-B6-C48; A19-B6-CX 3; A19-B6-C46;

177A19-B6-C47;

A19-B6-C48;

A19-B6-C49;

A19-B6-C50;

A19-B6-C51;

A19-B6-CS2;

A19-B6-C53;

A19-B6-C54;

A19-B6-C55;

A19-B6-C56;

A19-B6-C57;

A19-B6-C58;

A19-B6-C59;

A19-B6-C60;

A19-B6-C61;

A19-B6-C62;

A19-B6-C63;

A19-B6-C64;

A19-B6-C65;

A19-B6-C66;

A19-B6-C67;

A19-B6-C68;

A20-B6-C1;

A20-B6-C2;

A20-B6-C3;

A20-B6-C4;

A20-B6 ₁ -C5;

A20-B6-C6;

A20-B6-C7;

A20-B6-C8;

A20-B6-C9;

A20-B6-C1G;

A20-B6-C11;

A20-B6-C12;

A20-B6-C13;

A20-B6-C14;

A20-B6-C15;

A20-B6-C16;

A20-B6-C17;

A20-B6-C18;

A20-B6-C19;

A20-B6-C20;

A20-B6-C21;

A20-B6-C22;

A20-B6-C23;

A20-B6-C24;

A20-B6-C25;

A20-B6-C26;

A20-B6-C27;

A20-B6-C28;

A20-B6-C29;

A20-B6-C30;

A20-B6-C31;

A20-B6-C32;

A20-B6-C33;

A20-B6-C34;

A20-B6-C35;

A20-B6-C36;

A20-B6-C37;

A20-B6-C38;

A20-B6-C39;

A20-B6-C40;

A20-B6-C41;

A20-B6-C42;

A20-B6-C43;

A20-B6-C44;

A20-B6-C45;

A 20-Β 6-C 46;

A20-B6-C47;

A20-B6-C48;

A20-B6-C49;

A20-B6-C50;

A20-B6-C51;

A20-B6-C52;

A20-B6-C53;

A20-B6-C54;

A20-B6-C55;

A20-B6-C56;

A20-B6-C57;

A20-B6-C58;

A20-B6-C59;

A20-B6-C60;

A20-B6-C61;

A20-B6-C62;

A20-B6-C63;

A20-B6-C64;

A20-B6-C65;

A20-B6-C66;

A20-B6-C67;

A20-B6-C68;

A21-B6-C1;

A21-B6-C2;

A21-B6-C3;

A21-B6-C4;

A21-B6-C5;

A21-B6-C6;

A21-B6-C7;

A21-B6-C8;

A21-B6-C9;

A21-B6-C10;

A21-B6-C11;

A21-B6-C12;

A21-B6-C13;

A21-B6-C14;

A21-B6-C15;

A21-B6-C16;

A21-B6-C17;

A21-B6-C18;

A21-B6-C19;

A21-B6-C20;

A21-B6-C21;

A21-B6-C22;

A21-B6-C23;

A21-B6-C24;

A21-B6-C25;

A21-B6-C26;

A21-B6-C27;

A21-B6-C28;

A21-B6-C29;

A21-B6-C30;

A21-B6-C31;

A21-B6-C32;

A21-B6-C33;

A21-B6-C34;

A21-B6-C35;

A21-B6-C36;

A21-B6-C37;

A21-B6-C38;

A21-B6-C39;

A21-B6-C40;

A21-B6-C41;

A21-B6-C42;

A21-B6-C43;

A21-B6-C44;

A21-B6-C45;

A21-B6-C46;

A21-B6-C47;

A21-B6-C48;

A21-B6-C49;

A21-B6-C50;

A21-B6-C51;

A21-B6-C52;

A21-B6-C53;

A21-B6-C54;

A21-B6-C55;

A21-B6-C56;

A21-B6-C57;

A21-B6-C58;

A21-B6-C59;

A21-B6-C60;

A21-B6-C61;

A21-B6-C62;

A21-B6-C63;

A21-B6-C64;

A21-B6-C65;

A21-B6-C66;

A21-B6-C67;

A21-B6-C68;

A22-B6-C1;

A22-B6-C2;

A22-B6-C3;

A22-B6-C4;

A22-B6-C5;

A22-B6-C6;

A22-B6-C7;

• · · · · · · · · · · · · · · · ·

-178 • · · · · · · · · ·

A22-B6-C8;

A22-B6-C9;

A22-B6-C10;

A22-B6-C11;

A22-B6-C12;

A22-B6-C13;

A22-B6-C14;

A22-B6-C15;

A22-B6-C16;

A22-B6-C17;

A22-B6-C18;

A22-B6-C19;

A22-B6-C20;

A22-B6-C21;

A22-B6-C22;

A22-B6-C23;

A22-B6-C24;

A22-B6-C25;

A22-B6-C26;

A22-B6-C27;

A22-B6-C28;

A22-B6-C29;

A22-B6-C30;

A22-B6-C31;

A22-B6-C32;

A22-B6-C33;

A22-B6-C34;

A22-B6-C35;

A22-B6-C36;

A22-B6-C37;

A22-B6-C38;

A22-B6-C39;

A22-B6-C40;

A22-B6-C41;

A22-B6-C42;

A22-B6-C43;

A22-B6-C44;

A22-B6-C45;

A22-B6-C46;

A22-B6-C47;

A22-B6-C48;

A22-B6-C49;

A22-B6-C50;

A22-B6-C51;

A22-B6-C52;

A22-B6-C53;

A22-B6-C54;

A22-B6-C55;

A22-B6-C56;

A22-B6-C57;

A22-B6-C58;

A22-B6-C59;

A22-B6-C60;

A22-B6-C61;

A22-B6-C62;

A22-B6-C63;

A22-B6-C64;

A22-B6-C65;

A22-B6-C66;

A22-B6-C67;

A22-B6-C68;

A23-B6-C1;

A23-B6-C2;

A23-B6-C3;

A23-B6-C4;

A23-B6-C5;

A23-B6-C6;

A23-B6-C7;

A23-B6-C8;

A23-B6-C9;

A23-B6-C10;

A23-B6-C11;

A23-B6-C12;

A23-B6-C13;

A23-B6-C14;

A23-B6-C15;

A23-B6-C16;

A23-B6-C17;

A23-B6-C18;

A23-B6-C19;

A23-B6-C20;

A23-B6-C21;

A23-B6-C22;

A23-B6-C23;

A23-B6-C24;

A23-B6-C25;

A23-B6-C26;

A23-B6-C27;

A23-B6-C28;

A23-B6-C29;

A23-B6-C30;

A23-B6-C31;

A23-B6-C32;

A23-B6-C33;

A23-B6-C34;

A23-B6-C35;

A23-B6-C36;

A23-B6-C37;

A23-B6-C38;

A23-B0-C39;

A23-B6-C40;

A23-B6-C41;

A23-B6-C42;

A23-B6-C43;

A23-B6-C44;

A23-B6-C45;

A23-B6-C46;

A23-B6-C47;

A23-B6-C48;

A23-B6-C49;

A23-B6-C50;

A23-B6-C51;

A23-B6-C52;

A23-B6-C53;

A23-B6-C54;

A23-B6-C55;

A23-B6-C56;

A23-B6-C57;

A23-B6-C58;

A23-B0-C59;

A23-B6-C60;

A23-B6-C61;

A23-B6-C62;

A23-B6-C63;

A23-B6-C64;

A23-B6-C65;

A23-B6-C66;

A23-B6-C67;

A23-B6-C68;

A24-B6-C1;

A24-B6-C2;

A24-B6-C3;

A24-B6-C4;

A24-B6-C5;

A24-B6-C6;

A24-B6-C7;

A24-B6-C8;

A24-B6-C9;

A24-B6-C10;

A24-B6-C11;

A24-B6-C12;

A24-B6-C13;

A24-B6-C14;

A24-B6-C15;

A24-B6-C16;

A24-B6-C17;

A24-B6-C18;

A24-B6-C19;

A24-B6-C20;

A24-B6-C21;

A24-B6-C22;

A24-B6-C23;

A24-B6-C24;

A24-B6-C25;

A24-B6-C26;

A24-B6-C27;

A24-B6-C28;

A24-B6-C29;

A24-B6-C30;

A24-B6-C31;

A24-B6-C32;

A24-B6-C33;

A24-B6-C34;

A24-B6-C35;

A24-B6-C36;

- 179 • ··

A24-B6-C37;

A24-B6-C38;

A24-B6-C39;

A24-B6-C40;

A24-B6-C41;

A24-B6-C42;

A24-B6-C43;

A24-B6-C44;

A24-B6-C45;

A24-B6-C46;

A24-B6-C47;

A24-B6-C48;

A24-B6-C49;

A24-B6-C50;

A24-B6-C51;

A24-B6-C52;

A24-B6-C53;

A24-B6-C54;

A24-B6-C55;

A24-B6-C56;

A24-B6-C57;

A24-B6-C58;

A24-B6-C59;

A24-B6-C60;

A24-B6-C61;

A24-B6-C62;

A24-B6-C63;

(

A24-B6-C64;

A24-B6-C65;

A24-B6-C66;

A24-B6-C67;

A24-B6-C68;

A25-B6-C1;

A25-B6-C2;

A25-B6-C3;

A25-B6-C4;

A25-B6-C5;

A25-B6-C6;

A25-B6-C7;

A25-B6-C8;

A25-B6-C9;

A25-B6-C10;

A25-B6-C11;

A25-B6-C12;

A25-B6-C13;

A25-B6-C14;

A25-B6-C15;

A25-B6-C16;

A25-B6-C17;

A25-B6-C18;

A25-B6-C19;

A25-B6-C20;

A25-B6-C21;

A25-B6-C22;

A25-B6-C23;

A25-B6-C24;

A25-B6-C25;

A25-B6-C26;

A25-B6-C27;

A25-B6-C28;

A25-B6-C29;

A25-B6-C30;

A25-B6-C31;

A25-B6-C32;

A25-B6-C33;

A25-B6-C34;

A25-B6-C35;

A25-B6-C36;

A25-B6-C37;

A25-B6-C38;

A25-B6-C39;

A25-B6-C40;

A25-B6-C41;

A25-B6-C42;

A25-B6-C43;

A25-B6-C44;

A25-B6-C45;

A25-B6-C46;

A25-B6-C47;

A25-B6-C48;

A25-B6-C49;

A25-B6-C50;

A25-B6-C51;

A25-B6-C52;

A25-B6-C53;

A25-B6-C54;

A25-B6-C55;

A25-B6-C56;

A25B6-C57;

A25-B6-C58;

A25-B6-C59;

A25-B6-C60;

A25-B6-C61;

A25-B6-C62;

A25-B6-C63;

A25-B6-C64;

A25-B6-C65;

A25-B6-C66;

A25-B6-C67;

A25-B6-C68;

A26-B6-C1;

A26-B6-C2;

A26-B6-C3;

A26-B6-C4;

A26-B6-C5;

A26-B6-C6;

A26-B6-C7;

A26-B6-C8;

A26-B6-C9;

A26-B6-C10;

A26-B6-C11;

A26-B6-C12;

A26-B6-C13;

A26-B6-C14;

A26-B6-C15;

A26-B6-C16;

A26-B6-C17;

A26-B6-C18;

A26-B6-C19;

A26-B6-C20;

A26-B6-C21;

A26-B6-C22;

A26-B6-C23;

A26-B6-C24;

A26-B6-C25;

A26-B6-C26;

A26-B6-C27;

A26-B6-C28;

A26-B6-C29;

A26-B6-C30;

A26-B6-C31;

A26-B6-C32;

A26-B6-C33;

A26-B6-C34;

A26-B6-C35;

A26-B6-C36;

A26-B6-C37;

A26-B6-C38;

A26-B6-C39;

A26-B6-C40;

A26-B6-C41;

A26-B6-C42;

A26-B6-C43;

A26-B6-C44;

A26-B6-C45;

A26-B6-C46;

A26-B6-C47;

A26-B6-C48;

A26-B6-C49;

A26-B6-C50;

A26-B6-C51;

A26-B6-C52;

A26-B6-C53;

A26-B6-C54;

A26-B6-C55;

A26-B6-C56;

A26-B6-C57;

A26-B6-C58;

A26-B6-C59;

A26-B6-C60;

A26-B6-C61;

A26-B6-C62;

A26-B6-C63;

A26-B6-C64;

A26-B6-C65;

• * »9 · t ·· ···· · · · 9 9 9

98 9 C 9 9 9

- 9 • 9 9 9 9 0 9 99 9 99 9

A26-B6-C66; A27-B6-C31; A27-B6-C64; A28-B6-C29; A28-B6-C62; A26-B6-C67; A27-B6-C32; A27-B6-C65; A28-B6-C30; A28-B6-C63; A26-B6-C68; A27-B6-C33; A27-B6-C66; A28-B6-C31; A28-B6-C64; A27-B6-C1; A27-B6-C34; A27-B6-C67; A28-B6-C32; A28-B6-C65; A27-B6-C2; A27-B6-C35; A27-B6-C68; A28-B6-C33; A28-B6-C66; A27-B6-C3; A27-B6-C36; A28-B6-C1; A28-B6-C34; A28-B6-C67; A27-B6-C4; A27-B6-C37; A28-B6-C2; A28-B6-C35; A28-B6-C68; A27-B6-C5; A27-B6-C38; A28-B6-C3; A28-B6-C36; A29-B6-C1; A27-B6-C6; A27-B6-C39; A28-B6-C4; A28-B6-C37; A29-B6-C2; A27-B6-C7; A27-B6-C40; A28-B6-C5; A28-B6-C38; A29-B6-C3; A27-B6-C8; A27-B6-C41; A28-B6-C6; A28-B6-C39; A29-B6-C4; A27-B6-C9; A27-B6-C42; A28-B6-C7; A28-B6-C40; A29-B6-C5; A27-B6-C10; A27-B6-C43; A28-B6-C8; A28-B6-C41; A29-B6-C6; A27-B6-C11; A27-B6-C44; A28-B6-C9; A28-B6-C42; A29-B6-C7; A27-B6-C12; A27-B6-C45; A28-B6-C10; A28-B6-C43; A29-B6-C8; A27-B6-C13; A27-B6-C46; A28-B6-C11; A28-B6-C44; A29-B6-C9; A27-B6-C14; A27-B0-C47; A28-B6-C12; A28-B6-C45; A29-B6-C10; A27-B6-C15; A27-B6-C48; A28-B6-C13; A28-B6-C46; A29-B6-C11; A27-B6-C16; A27-B6-C49; A28-B6-C14; A28-B6-C47; A29-B6-C12; A27-B6-C17; A27-B6-C50; A28-B6-C15; A28-B6-C48; A29-B6-C13; A27-B6-C18; A27-B6-C51; A28-B6-C16; A28-B6-C49; A29-B6-C14; A27-B6-C19; A27-B6-C52; A28-B6-C17; A28-B6-C50; A29-B6-C15; A27-B6-C20; A27-B6-C53; A28-B6-C18; A28-B6-C51; A29-B6-C16; A27-B6-C21; A27-B6-C54; A28-B6-C19; A28-B6-C52; A29-B6-C17; A27-B6-C22; A27-B6-C55; A28-B6-C20; A28-B6-C53; A29-B6-C18; A27-B6-C23; A27-B6-C56; A28-B6-C21; A28-B6-C54; A29-B6-C19; A27-B6-C24; A27-B6-C57; A28-B6-C22; A28-B6-C55; A29-B6-C20; A27-B6-C25; A27-B6-C58; A28-B6-C23; A28-B6-C56; A29-B6-C21; A27-B6-C26; A27-B6-C59; A28-B6-C24; A28-B6-C57; A29-B6-C22; A27-B6-C27; A27-B6-C60; A28-B6-C25; A28-B6-C58; A29-B6-C23; A27-B6-C28; A27-B6-C61; A28-B6-C26; A28-B6-C59; A29-B6-C24; A27-B6-C29; A27-B6-C62; A28-B6-C27; A28-B6-C60; A29-B6-C25; A27-B6-C30; A27-B6-C63; A28-B6-C28; A28-B6-C61; A29-B6-C26;

- 181 -

A29-B6-C27; A29-B6-C60; A30-B6-C25; A30-B6-C58; A31-B6-C23; A29-B6-C28; A29-B6-C61; A30-B6-C26; A30-B6-C59; A31-B6-C24; A29-B6-C29; A29-B6-C62; A30-B6-C27; A30-B6-C60; A31-B6-C25; A29-B6-C30; A29-B6-C63; A30-B6-C28; A30-B6-C61; A31-B6-C26; A29-B6-C31; A29-B6-C64; A30-B6-C29; A30-B6-C62; A31-B6-C27; A29-B6-C32; A29-B6-C65; A30-B6-C30; A30-B6-C63; A31-B6-C28; A29-B6-C33; A29-B6-C66; A30-B6-C31; A30-B6-C64; A31-B6-C29; A29-B6-C34; A29-B6-C67; A30-B6-C32; A30-B6-C65; A31-B6-C30; A29-B6-C35; A29-B6-C68; A30-B6-C33; A30-B6-C66; A31-B6-C31; A29-B6-C36; A30-B6-C1; A30-B6-C34; A30-B6-C67; A31-B6-C32; A29-B6-C37; A30-B6-C2; A30-B6-C35; A30-B6-C68; A3X-B6-C33; A29-B6-C38; A30-B6-C3; A30-B6-C36; A31-B6-C1; A31-B6-C34; A29-B6-C39; A30-B6-C4; A30-B6-C37; A31-B6-C2; A31-B6-C35; A29-B6-C40; A30-B6-C5; A30-B6-C38; A31-B6-C3; A31-B6-C36; A29-B6-C41; A30-B6-C6; A30-B6-C39; A31-B6-C4; A31-B6-C37; A29-B6-C42; A30-B6-C7; A30-B6-C40; A31-B6-C5; A31-B6-C38; A29-B6-C43; A30-B6-C8; A30-B6-C41; A31-B6-C6; A31-B6-C39; A29-B6-C44; A30-B6-C9; A30-B6-C42; A31-B6-C7; A31-B6-C40; A29-B6-C45; A30-B6-C10; A30-B6-C43; A31-B6-C8; A31-B6-C41; A29-B6-C46; A30-B6-C11; A30-B6-C44; A31-B6-C9; A31-B6-C42; A29-B6-C47; A30-B6-C12; A30-B6-C45; A31-B6-C10; A31-B6-C43; A29-B6-C48; A30-B6-C13; A30-B6-C46; A31-B6-C11; A31-B6-C44; A29-B6-C49; A30-B6-C14; A30-B6-C47; A31-B6-C12; A31-B6-C45; A29-B6-C50; A30-B6-C15; A30-B6-C48; A31-B6-C13; A31-B6-C46; A29-B6-C51; A30-B6-C16; A30-B6-C49; A31-B6-C14; A31-B6-C47; A29-B6-C52; A30-B6-C17; A30-B6-C50; A31-B6-C15; A31-B6-C48; A29-B6-, C53; A30-B6-C18; A30-B6-C51; A31-B6-C16; A31-B6-C49; A29-B6-C54; A30-B6-C19; A30-B6-C52; A31-B6-C17; A31-B6-C50; A29-B6-C55; A30-B6-C20; A30-B6-C53; A31-B6-C18; A31-B6-C51; A29-B6-C56; A30-B6-C21; A30-B6-C54; A31-B6-C19; A31-B6-C52; A29-B6-C57; A30-B6-C22; A30-B6-C55; A31-B6-C20; A31-B6-C53; A29-B6-C58; A30-B6-C23; A30-B6-C56; A31-B6-C21; A31-B6-C54; A29-B6-C59 A30-B6-C24; A30-B6-C57; A31-B6-C22; A31-B6-C55;

• * * · · · · · · · · · · · · · · · · · · · · ·

A · · · · 4 «· ·«

- 182 • · t t t · t

A31-B6-C56;

A31-B6-C57;

A31-B6-C58;

A31-B6-C59;

A31-B6-C60;

A31-B6-C61;

A31-B6-C62;

A31-B6-C63;

A31-B6-C64;

A31-B6-C65;

A31-B6-C66;

A31-B6-C67;

A31-B6-C68;

A32-B6-C1;

A32-B6-C2;

A32-B6-C3;

A32-B6-C4;

A32-B6-C5;

A32-B6-C6;

A32-B6-C7;

A32-B6-C8;

A32-B6-C9;

A32-B6-C10;

A32-B6-C11;

A32-B6-C12;

A32-B6-C13;

A32-B6-C1.4;

A32-B6-C15;

A32-B6-C16;

A32-B6-C17;

A32-B6-C18;

A32-B6-C19;

A32-B6-C20;

A32-B6-C21;

A32-B6-C22;

A32-B6-C23;

A32-B6-C24;

A32-B6-C25;

A32-B6-C26;

A32-B6-C27;

A32-B6-C28;

A32-B6-C29;

A32-B6-C30;

A32-B6-C31;

A32-B6-C32;

A32-B6-C33;

A32-B6-C34;

A32-B6-C35;

A32-B6-C36;

A32-B6-C37;

A32-B6-C38;

A32-B6-C39;

A32-B6-C40;

A32-B6-C41;

A32-B6-C42;

A32-B6-C43;

A32-B6-C44;

A32-B6-C45;

A32-B6-C46;

A32-B6-C47;

A32-B6-C48;

A32-B6-C49;

A32-B6-C50;

A32-B6-C51;

A32-B6-C52;

A32-B6-C53;

A32-B6-C54;

A32-B6-C55;

A32-B6-C56;

A32-B6-C57;

A32-B6-C58;

A32-B6-C59;

A32-B6-C60;

A32-B6-C61;

A32-B6-C62;

A32-B6-C63;

A32-B6-C64;

A32-B6-C65;

A32-B6-C66;

A32-B6-C67;

A32-B6-C68;

A33-B6-C1;

A33-B6-C2;

A33-B6-C3;

A33-B6-C4;

A33-B6-C5;

A33-B6-C6;

A33-B6-C7;

A33-B6-C8;

A33-B6-C9;

A33-B6-C10;

A33-B6-C11;

A33-B6-C12;

A33-B6-C13;

A33-B6-C14;

A33-B6-C15;

A33-B6-C16;

A33-B6-C17;

A33-B6-C18;

A33-B6-C19;

A33-B6-C20;

A33-B6-C21;

A33-B6-C22;

A33-B6-C23;

A33-B6-C24;

A33-B6-C25;

A33-B6-C26;

A33-B6-C27;

A33-B6-C28;

A33-B6-C29;

A33-B6-C30;

A33-B6-C31;

A33-B6-C32;

A33-B6-C33;

A33-B6-C34;

A33-B6-C35;

A33-B6-C36;

A33-B6-C37;

A33-B6-C38;

A33-B6-C39;

A33-B6-C40;

A33-B6-C41;

A33-B6-C42;

A33-B6-C43;

A33-B6-C44;

A33-B6-C45;

A33-B6-C46;

A33-B6-C47;

A33-B6-C48;

A33-B6-C49;

A33-B6-C50;

A33-B6-C51;

A33-B6-C52;

A33-B6-C53;

A33-B6-C54;

A33-B6-C55;

A33-B6-C56;

A33-B6-C57;

A33-B6-C58;

A33-B6-C59;

A33-B6-C60;

A33-B6-C61;

A33-B6-C62;

A33-B6-C63;

A33-B6-C64;

A33-B6-C65;

A33-B6-C66;

A33-B6-C67;

A33-B6-C68;

A34-B6-C1;

A34-B6-C2;

A34-B6-C3;

A34-B6-C4;

A34-B6-C5;

A34-B6-C6;

A34-B6-C7;

A34-B6-C8;

A34-B6-C9;

A34-B6-C10;

A34-B6-C11;

A34-B6-C12;

A34-B6-C13;

A34-B6-C14;

A34-B6-C15;

A34-B6-C16;

-183 -

and • · • · 4 • · • · ♦ · · 4 · • · 4 4 ·· • · • 9 4 • » 9 4 4 · • 9 9 4 • · • · 4 • 4 9 • · «· * 4 • · · 49 4 4

A34-B6-C17; A34-B6-C50; A35-B6-C15; A35-B6-C48; A36-B6-C13; A34-B6-C18; A34-B6-C51; A35-B6-C16; A35-B6-C49; A36-B6-C14; A34-B6-C19; A34-B6-C52; A35-B6-C17; A35-B6-C50; A36-B6-C15; A34-B6-C20; A34-B6-C53; A35-B6-C18; A35-B6-C51; A36-B6-C16; A34-B6-C21; A34-B6-C54; A35-B6-C19; A35-B6-C52; A36-B6-C17; A34-B6-C22; A34-B6-C55; A35-B6-C20; A35-B6-C53; A36-B6-C18; A34-B6-C23; A34-B6-C56; A35-B6-C21; A35-B6-C54; A36-B6-C19; A34-B6-C24; A34-B6-C57; A35-B6-C22; A35-B6-C55; A36-B6-C20; A34-B6-C25; A34-B6-C58; A35-B6-C23; A35-B6-C56; A36-B6-C21; A34-B6-C26; A34-B6-C59; A35-B6-C24; A35-B6-C57; A36-B6-C22; A34-B6-C27; A34-B6-C60; A35-B6-C25; A35-B6-C58; A36-B6-C23; A34-B6-C28; A34-B6-C61; A35-B6-C26; A35-B6-C59; A36-B6-C24; A34-B6-C29; A34-B6-C62; A35-B6-C27; A35-B6-C60; A36-B6-C25; A34-B6-C30; A34-B6-C63; A35-B6-C28; A35-B6-C61; A36-B6-C26; A34-B6-C31; A34-B6-C64; A35-B6-C29; A35-B6-C62; A36-B6-C27; A34-B6-C32; A34-B6-C65; A35-B6-C30; A35-B6-C63; A36-B6-C28; A34-B6-C33; A34-B6-C66; A35-B6-C31; A35-B6-C64; A36-B6-C29; A34-B6-C34; A34-B6-C67; A35-B6-C32; A35-B6-C65; A36-B6-C30; A34-B6-C35; A34-B6-C68; A35-B6-C33; A35-B6-C66; A36-B6-C31; A34-B6-C36; A35-B6-C1; A35-B6-C34; A35-B6-C67; A3O-B6-C32; A34-B6-C37; A35-B6-C2; A35-B6-C35; A35-B6-C68; A36-B6-C33; A34-B6-C38; A35-B6-C3; A35-B6-C36; A36-B6-C1; A36-B6-C34; A34-B6-C39; A35-B6-C4; A35-B6-C37; A36-B6-C2; A36-B6-C35; A34-B6-C40; A35-B6-C5; A35-B6-C38; A36-B6-C3; A36-B6-C36; A34-B6-C41; A35-B6-C6; A35-B6-C39; A36-B6-C4; A36-B6-C37; A34-B6-C42; A35-B6-C7; A35-B6-C40; A36-B6-C5; A36-B6-C38; Α34-Β6-ς43; A35-B6-C8; A35-B6-C41; A36-B6-C6; A36-B6-C39; A34-B6-C44; A35-B6-C9; A35-B6-C42; A36-B6-C7; A36-B6-C40; A34-B6-C45; A35-B6-C10; A35-B6-C43; A36-B6-C8; A36-B6-C41; A34-B6-C46; A35-B6-C11; A35-B6-C44; A36-B6-C9; A36-B6-C42; A34-B6-C47; A35-B6-C12; A35-B6-C45; A36-B6-C10; A36-B6-C43; A34-B6-C48; A35-B6-C13; A35-B6-C46; A36-B6-C11; A36-B6-C44; A34-B6-C49; A35-B6-C14; A35-B6-C47; A36-B6-C12; A36-B6-C45;

-184 ft ft ft ft ft ft c c c c c t t t 18 18 18 18 18 18 18 18 18 18 18 18 18

A36-B6-C46;

A36-B6-C47;

A36-B6-C48;

A36-B6-C49;

A36-B6-C50;

A36-B6-C51;

A36-B6-C52;

A36-B6-C53;

A36-B6-C54;

A36-B6-C55;

A36-B6-C56;

A36-B6-C57;

A36-B6-C58;

A36-B6-C59;

A36-B6-C60;

A36-B6-C61;

A36-B6-C62;

A36-B6-C63;

A36-B6-C64;

A36-B6-C65;

A36-B6-C66;

A36-B6-C67;

A36-B6-C68;

A37-B6-C1;

A37-B6-C2;

A37-B6-C3;

A37-B6-C4;

A37-B6-C5;

A37-B6-C6;

A37-B6-C7;

A37-B6-C8;

A37-B6-C9;

A37-B6-C10;

A37-B6-C11;

A37-B6-C12;

A37-B6-C13;

A37-B6-C14;

A37-B6-C15;

A37-B6-C16;

A37-B0-C17;

A37-B6-C18;

A37-B6-C19;

A37-B6-C20;

A37-B6-C21;

A37-B6-C22;

A37-B6-C23;

A37-B6-C24;

A37-B6-C25;

A37-B6-C26;

A37-B6-C27;

A37-B6-C28;

A37-B6-C29;

A37-S6-C30;

A37-B6-C31;

A37-B6-C32;

A37-B6-C33;

A37-B6-C34;

A37-B6-C35;

A37-B6-C36;

A37-B6-C37;

A37-B6-C38;

A37-B6-C39;

A37-B6-C40;

A37-B6-C41;

A37-B6-C42;

A37-B6-C43;

A37-B6-C44;

A37-B6-C45;

A37-B6-C46;

A37-B6-C47;

A37-B6-C48;

A37-B6-C49;

A37-B6-C50;

A37-B6-C51;

A37-B6-C52;

A37-B6-C53;

A37-B6-C54;

A37-B6-C55;

A37-B6-C56;

A37-B6-C57;

A37-B6-C58;

A37-B6-C59;

A37-B6-C60

A37-B6-C61;

A37-B6-C62;

A37-B6-C63;

A37-B6-C64;

A37-B6-C65;

A37-B6-C66;

A37-B6-C67;

A37-B6-C68;

A38-B6-C1;

A38-B6-C2;

A38-B6-C3;

A38-B6-C4;

A38-B6-C5;

A38-B6-C6;

A38-B6-C7;

A38-B6-C8;

A38-B6-C9;

A38-B6-C10;

A38-B6-C11;

A38-B6-C12;

A38-B6-C13;

A38-B6-C14;

A38-B6-C15;

A38-B6-C16;

A38-B6-C17;

A38-B6-C18;

A38-B6-C19;

A38-B6-C20;

A38-B6-C21;

A38-B6-C22;

A38-B6-C23;

A38-B6-C24;

A38-B6-C25;

A38-B6-C26;

A38-B6-C27;

A38-B6-C28;

A38-B6-C29;

A38-B6-C30;

A38-B6-C31;

A38-B6-C32;

A38-B6-C33;

A38-B6-C34;

A38-B6-C35;

A38-B6-C36;

A38-B6-C37;

A38-B6-C38;

A38-B6-C39;

A38-B6-C40;

A38-B6-C41;

A38-B6-C42;

A38-B6-C43;

A38-B6-C44;

A38-B6-C45;

A38-B6-C46;

A38-B6-C47;

A38-B6-C48;

A38-B6-C49;

A38-B6-C50;

A38-B6-C51;

A38-B6-C52;

A38-B6-C53;

A38-B6-C54;

A38-B6-C55;

A38-B6-C56;

A38-B6-C57;

A38-B6-C58;

A38-B6-C59;

A38-B6-C60;

A38-B6-C61;

A38-B6-C62;

A38-B6-C63;

A38-B6-C64;

A38-B6-C65;

A38-B6-C66;

A38-B6-C67;

A38-B6-C68;

A1-B7-C1;

A1-B7-C2;

A1-B7-C3;

A1-B7-C4;

A1-B7-C5;

A1-B7-C6;

ί

AND

-185A1-B7-C7;

A1-B7-C8;

A1-B7-C9;

A1-B7-C10;

A1-B7-C11;

A1-B7-C12;

A1-B7-C13;

A1-B7-C14;

A1-B7-C15;

A1-B7-C16;

A1-B7-C17;

A1-B7-C18;

A1-B7-C19;

A1-B7-C20;

A1-B7-C21;

A1-B7-C22;

A1-B7-C23;

A1-B7-C24;

A1-B7-C25;

A1-B7-C26;

A1-B7-C27;

A1-B7-C28;

A1-B7-C29;

A1-B7-C30;

A1-B7-C31;

A1-B7-C32;

A1-B7-Q3;

A1-B7-C34;

A1-B7-C35;

A1-B7-C36;

A1-B7-C37;

A1-B7-C38;

A1-B7-C39;

A1-B7-C40;

A1-B7-C41;

A1-B7-C42;

A1-B7-C43;

A1-B7-C44;

A1-B7-C45;

A1-B7-C46;

A1-B7-C47;

A1-B7-C48;

A1-B7-C49;

A1-B7-C50;

A1-B7-C51;

A1-B7-C52;

A1-B7-C53;

A1-B7-C54;

A1-B7-C55;

A1-B7-C56;

A1-B7-C57;

A1-B7-C58;

A1-B7-C59;

A1-B7-C60;

A1-B7-C61;

A1-B7-C62;

A1-B7-C63;

A1-B7-C64;

A1-B7-C65;

A1-B7-C66;

A1-B7-C67;

A1-B7-C68;

A2-B7-C1;

A2-B7-C2;

A2-B7-C3;

A2-B7-C4;

A2-B7-C5;

A2-B7-C6;

A2-B7-C7;

A2-B7-C8;

A2-B7-C9;

A2-B7-C10;

A2-B7-C11;

A2-B7-C12;

A2-B7-C13;

A2-B7-C14;

A2-B7-C15;

A2-B7-C16;

A2-B7-C17;

A2-B7-C18;

A2-B7-C19;

A2-B7-C20;

A2-B7-C21;

A2-B7-C22;

A2-B7-C23;

A2-B7-C24;

A2-B7-C25;

A2-B7-C26;

A2-B7-C27;

A2-B7-C28;

A2-B7-C29;

A2-B7-C30;

A2-B7-C31;

A2-B7-C32;

A2-B7-C33;

A2-B7-C34;

A2-B7-C35;

A2-B7-C36;

A2-B7-C37;

A2-B7-C38;

A2-B7-C39;

A2-B7-C40;

A2-B7-C41;

A2-B7-C42;

A2-B7-C43;

A2-B7-C44;

A2-B7-C45;

A2-B7-C46;

A2-B7-C47;

A2-B7-C48;

A2-B7-C49;

A2-B7-C50;

A2-B7-C51;

A2-B7-C52;

A2-B7-C53;

A2-B7-C54;

A2-B7-C55;

A2-B7-C56;

A2-B7-C57;

A2-B7-C58;

A2-B7-C59;

A2-B7-C60;

A2-B7-C61;

A2-B7-C62;

A2-B7-C63;

A2-B7-C64;

A2-B7-C65;

A2-B7-C66;

A2-B7-C67;

A2-B7-C68;

A3-B7-C1;

A3-B7-C2;

A3-B7-C3;

A3-B7-C4;

A3-B7-C5;

A3-B7-C6;

A3-B7-C7;

A3-B7-C8;

A3-B7-C9;

A3-B7-C10;

A3-B7-C11;

A3-B7-C12;

A3-B7-C13;

A3-B7-C14;

A3-B7-C15;

A3-B7-C16;

A3-B7-C17;

A3-B7-C18;

A3-B7-C19;

A3-B7-C20;

A3-B7-C21;

A3-B7-C22;

A3-B7-C23;

A3-B7-C24;

A3-B7-C25;

A3-B7-C26;

A3-B7-C27;

A3-B7-C28;

A3-B7-C29;

A3-B7-C30;

A3-B7-C31;

A3-B7-C32;

A3-B7-C33;

A3-B7-C34;

J.

A3-B7-C35;

-186 9 9 9 99 9 9 9

98 9 4 4 4 4

9 99 99 999 94 999

A3-B7-C36; A4-B7-C1; A4-B7-C34; A4-B7-C67; A5-B7-C32; A3-B7-C37; A4-B7-C2; A4-B7-C35; A4-B7-C68; A5-B7-C33; A3-B7-C38; A4-B7-C3; A4-B7-C36; A5-B7-C1; A5-B7-C34; A3-B7-C39; A4-B7-C4; A4-B7-C37; A5-B7-C2; A5-B7-C35; A3-B7-C40; A4-B7-C4; A4-B7-C38; A5-B7-C3; A5-B7-C36; A3-B7-C41; A4-B7-C6; A4-B7-C39; A5-B7-C4; A5-B7-C37; A3-B7-C42; A4-B7-C7; A4-B7-C40; A5-B7-C5; A5-B7-C38; A3-B7-C43; A4-B7-C8; A4-B7-C41; A5-B7-C6; A5-B7-C39; A3-B7-C44; A4-B7-C9; A4-B7-C42; A5-B7-C7; A5-B7-C40; A3-B7-C45; A4-B7-C10; A4-B7-C43; A5-B7-C8; A5-B7-C41; A3-B7-C46; A4-B7-C11; A4-B7-C44; A5-B7-C9; A5-B7-C42; A3-B7-C47; A4-B7-C12; A4-B7-C45; A5-B7-C10; A5-B7-C43; A3-B7-C48; A4-B7-C13; A4-B7-C46; A5-B7-C11; A5-B7-C44; A3-B7-C49; A4-B7-C14; A4-B7-C47; A5-B7-C12; A5-B7-C45; A3-B7-C50; A4-B7-C15; A4-B7-C48; A5-B7-C13; A5-B7-C46; A3-B7-C51; A4-B7-C16; A4-B7-C50; A5-B7-C14; A5-B7-C47; A3-B7-C52; A4-B7-C17; A4-B7-C50; A5-B7-C15; A5-B7-C48; A3-B7-C53; A4-B7-C18; A4-B7-C51; A5-B7-C16; A5-B7-C49; A3-B7-C54; A4-B7-C19; A4-B7-C52; A5-B7-C17; A5-B7-C50; A3-B7-C55; A4-B7-C20; A4-B7-C53; A5-B7-C18; A5-B7-C51; A3-B7-C55; A4-B7-C21; A4-B7-C54; A5-B7-C19; A5-B7-C52; A3-B7-C57; A4-B7-C22; A4-B7-C55; A5-B7-C20; A5-B7-C53; A3-B7-C58; A4-B7-C23; A4-B7-C55; A5-B7-C21; A5-B7-C54; A3-B7-C59; A4-B7-C24; A4-B7-C57; A5-B7-C22; A5-B7-C55; A3-B7-C60; A4-B7-C25; A4-B7-C58; A5-B7-C23; A5-B7-C56; A3-B7-C61; A4-B7-C26; A4-B7-C59; A5-B7-C24; A5-B7-C57; A3-B7-C62; Ί A4-B7-C27; A4-B7-C60; A5-B7-C25; A5-B7-C58; A3-B7-C63; A4-B7-C28; A4-B7-C61; A5-B7-C26; A5-B7-C59; A3-B7-C64; A4-B7-C29; A4-B7-C62; A5-B7-C27; A5-B7-C60; A3-B7-C65; A4-B7-C30; A4-B7-C63; A5-B7-C28; A5-B7-C61; A3-B7-C66; A4-B7-C31; A4-B7-C64; A5-B7-C29; A5-B7-C62; A3-B7-C67; A4-B7-C32; A4-B7-C65; A5-B7-C30; A5-B7-C63; A3-B7-C68; A4-B7-C33; A4-B7-C66; A5-B7-C31; A5-B7-C64;

• ·

-187A5-B7-C65;

A5-B7-C66;

A5-B7-C67;

A5-B7-C68;

A6-B7-C1;

A6-B7-C2;

A6-B7-C3;

A6-B7-C4;

A6-B7-C5;

A6-B7-C6;

A6-B7-C7;

A6-B7-C8;

A6-B7-C9;

A6-B7-C10;

A6-B7-C11;

A6-B7-C12;

A6-B7-C13;

A6-B7-C14;

A6-B7-C15;

A6-B7-C16;

A6-B7-C17;

A6-B7-C18;

A6-B7-C19;

A6-B7-C20;

A6-B7-C21;

A6-B7-C22;

A6-B7-C23;

A6-B7-C24;

A6-B7-C25;

A6-B7-C26;

A6-B7-C27;

A6-B7-C28;

A6-B7-C29;

A6-B7-C30;

A6-B7-C31;

A6-B7-C32;

A6-B7-C33;

A6-B7-C34;

A6-B7-C35;

A6-B7-C36;

A6-B7-C37;

A6-B7-C38;

A6-B7-C39;

A6-B7-C40;

A6-B7-C41;

A6-B7-C42;

A6-B7-C43;

A6-B7-C44;

A6-B7-C45;

A6-B7-C46;

A6-B7-C47;

A6-B7-C48;

A6-B7-C49;

A6-B7-C50;

A6-B7-C51;

A6-B7-C52;

A6-B7-C53;

A6-B7-C54;

A6-B7-C55;

A6-B7-C55;

A6-B7-C57;

A6-B7-C58;

A6-B7-C59;

A6-B7-C60;

A6-B7-C61;

A6-B7-C62;

A6-B7-C63;

A6-B7-C64;

A6-B7-C65;

A6-B7-C66;

A6-B7-C67;

A6-B7-C68;

A7-B7-C1;

A7-B7-C2;

A7-B7-C3;

A7-B7-C4;

A7-B7-C5;

A7-B7-C6;

A7-B7-C7;

A7-B7-C8;

A7-B7-C9;

A7-B7-C10;

A7-B7-C11;

A7-B7-C12;

A7-B7-C13;

A7-B7-C14;

A7-B7-C15;

A7-B7-C16;

A7-B7-C17;

A7-B7-C18;

A7-B7-C19;

A7-B7-C20;

A7-B7-C21;

A7-B7-C22;

A7-B7-C23;

A7-B7-C24;

A7-B7-C25;

A7-B7-C26;

A7-B7-C27;

A7-B7-C28;

A7-B7-C29;

A7-B7-C30;

A7-B7-C31;

A7-B7-C32;

A7-B7-C33;

A7-B7-C34;

A7-B7-C35;

A7-B7-C36;

A7-B7-C37;

A7-B7-C38;

A7-B7-C39;

A7-B7-C40;

A7-B7-C41;

A7-B7-C42;

A7-B7-C43;

A7-B7-C44;

A7-B7-C45;

A7-B7-C46;

A7-B7-C47;

A7-B7-C48;

A7-B7-C49;

A7-B7-C50;

A7-B7-C51;

A7-B7-C52;

A7-B7-C53;

A7-B7-C54;

A7-B7-C55;

A7-B7-C56;

A7-B7-C57;

A7-B7-C58;

A7-B7-C59;

A7-B7-C60;

A7-B7-C61;

A7-B7-C62;

A7-B7-C63;

A7-B7-C64;

A7-B7-C65;

A7-B7-C66;

A7-B7-C67;

A7-B7-C68;

A8-B7-C1;

A8-B7-C2;

A8-B7-C3;

A8-B7-C4;

A8-B7-C5;

A8-B7-C6;

A8-B7-C7;

A8-B7-C8;

A8-B7-C9;

A8-B7-C10;

A8-B7-C11;

A8-B7-C12;

A8-B7-C13;

A8-B7-C14;

A8-B7-C15;

A8-B7-C16;

A8-B7-C17;

A8-B7-C18;

A8-B7-C19;

A8-B7-C20;

A8-B7-C21;

A8-B7-C22;

A8-B7-C23;

A8-B7-C24;

A8-B7-C25;

-188ΦΦΦ φ · φ ΦΦΦ φφ φφ ΦΦΦ

A8-B7-C26;

A8-B7-C27;

A8-B7-C28;

A8-B7-C29;

A8-B7-C30;

A8-B7-C31;

A8-B7-C32;

A8-B7-C33;

A8-B7-C34;

A8-B7-C35;

A8-B7-C36;

A8-B7-C37;

A8-B7-C38;

A8-B7-C39;

A8-B7-C40;

A8-B7-C41;

A8-B7-C42;

A8-B7-C43;

A8-B7-C44;

A8-B7-C45;

A8-B7-C46;

A8-B7-C47;

A8-B7-C48;

88-B7-C49;

A8-B7-C50;

A8-B7-C51;

A8-B7-C52J

A8-B7-C53;

A8-B7-C54;

A8-B7-C55;

A8-B7-C56;

A8-B7-C57;

A8-B7-C58;

A8-B7-C59;

A8-B7-C60;

A8-B7-C61;

A8-B7-C62;

A8-B7-C63;

A8-B7-C64;

A8-B7-C65;

A8-B7-C66;

A8-B7-C67;

A8-B7-C68;

A9-B7-C1;

A9-B7-C2;

A9-B7-C3;

A9-B7-C4;

A9-B7-C5;

A9-B7-C6;

A9-B7-C7;

A9-B7-C8;

A9-B7-C9;

A9-B7-C10;

A9-B7-C11;

A9-B7-C12;

9 9 -B ' ⁷ -C ¹³ ;

A9-B7-C14;

A9-B7-C15;

A9-B7-C16;

A9-B7-C17;

A9-B7-C18;

A9-B7-C19;

A9-B7-C20;

A9-B7-C21;

A9-B7-C22;

A9-B7-C23;

A9-B7-C24;

A9-B7-C25;

A9-B7-C26;

A9-B7-C27;

A9-B7-C28;

A9-B7-C29;

A9-B7-C30;

99-B7-C31;

A9-B7-C32;

A9-B7-C33;

99-B7-C34;

99-B7-C35;

99-B7-C36;

99-B7-C37;

99-B7-C38;

A9-B7-C39;

99-B7-C40;

99-B7-C41;

99-B7-C42;

A9-B7-C43;

A9-B7-C44;

A9-B7-C45;

A9-B7-C46;

99-B7-C47;

99-B7-C48;

99-B7-C49;

A9-B7-C50;

99-B7-C51;

99-B7-C52;

A9-B7-C53;

99-B7-C54;

99-B7-C55;

99-B7-C56;

99-B7-C57;

99-B7-C58;

A9-B7-C59;

99-B7-C60;

99-B7-C61;

A9-B7-C62;

99-B7-C63;

99-B7-C64;

99-B7-C65;

A9-B7-C66;

A9-B7-C67;

A9-B7-C68;

A10-B7-C1;

A10-B7-C2;

A10-B7-C3;

A10-B7-C4;

A10-B7-C5;

A10-B7-C6;

A10-B7-C7;

A10-B7-C8;

A10-B7-C9;

A10-B7-C10;

A10-B7-C11;

A10-B7-C12;

A10-B7-C13;

A10-B7-C14;

A10-B7-C15;

A10-B7-C16;

A10-B7-C17;

A10-B7-C18;

A10-B7-C19;

A10-B7-C20;

A10-B7-C21;

A10-B7-C22;

A10-B7-C23;

A10-B7-C24;

A10-B7-C25;

A10-B7-C26;

A10-B7-C27;

A10-B7-C28;

A10-B7-C29;

A10-B7-C30;

A10-B7-C31;

A10-B7-C32;

A10-B7-C33;

A10-B7-C34;

A10-B7-C35;

A10-B7-C36;

A10-B7-C37;

A10-B7-C38;

A10-B7-C39;

A10-B7-C40;

A10-B7-C41;

A10-B7-C42;

A10-B7-C43;

A10-B7-C44;

A10-B7-C45;

A10-B7-C46;

A10-B7-C47;

A10-B7-C48;

A10-B7-C49;

A10-B7-C50;

A10-B7-C51;

A10-B7-C52;

A10-B7-CS3;

A10-B7-C54;

-189 t · tftf tftf tftf tftf tftf tftf tftf tftf tftf tftf tftf tftf tftf tftf

A10-B7-C55;

A10-B7-C56;

A10-B7-C57;

A10-B7-C58;

A10-B7-C59;

A10-B7-C60;

A10-B7-C61;

A10-B7-C62;

A10-B7-C63;

A10-B7-C64;

A10-B7-C65;

A10-B7-C66;

A10-B7-C67;

A10-B7-C68;

A11-B7-C1;

A11-B7-C2;

A11-B7-C3;

A11-B7-C4;

A11-B7-C5;

A11-B7-C6;

A11-B7-C7;

A11-B7-C8;

A11-B7-C9;

A11-B7-C10;

A11-B7-C11;

A11-B7-C12;

A11-B7 _T C13;

A11-B7-C14;

A11-B7-C15;

A11-B7-C16;

A11-B7-C17;

A11-B7-C18;

A11-B7-C19;

A11-B7-C20;

A11-B7-C21;

A1I-B7-C22;

A11-B7-C23;

A11-B7-C24;

A11-B7-C25;

A11-B7-C26;

A11-B7-C27;

A11-B7-C28;

A1I-B7-C29;

A11-B7-C30;

A11-B7-C31;

A11-B7-C32;

A11-B7-C33;

A11-B7-C34;

A11-B7-C35;

A11-B7-C36;

A11-B7-C37;

A11-B7-C38;

A11-B7-C39;

A11-B7-C40;

A11-B7-C41;

A11-B7-C42;

A11-B7-C43;

A11-B7-C44;

A11-B7-C45;

A11-B7-C46;

A11-B7-C47;

A11-B7-C48;

A11-B7-C49;

A11-B7-C50;

A11-B7-C51;

A11-B7-C52;

A11-B7-C53;

A11-B7-C54;

A11-B7-C55;

A11-B7-C56;

A11-B7-C57;

A11-B7-C58;

A11-B7-C59;

A11-B7-C60;

A11-B7-C61;

A11-B7-C62;

A11-B7-C63;

A11-B7-C64;

A11-B7-C65;

A11-B7-C66;

A11-B7-C67;

A11-B7-C68;

A12-B7-C1;

A12-B7-C2;

A12-B7-C3;

A12-B7-C4;

A12-B7-C5;

A12-B7-C6;

A12-B7-C7;

A12-B7-C8;

A12-B7-C9;

A12-B7-C10;

A12-B7-C11;

A12-B7-C12;

A12-B7-C13;

A12-B7-C14;

A12-B7-C15;

A12-B7-C16;

A12-B7-C17;

A12-B7-C18;

A12-B7-C19;

A12-B7-C20;

A12-B7-C21;

A12-B7-C22;

A12-B7-C23;

A12-B7-C24;

A12-B7-C25;

A12-B7-C26;

A12-B7-C27;

A12-B7-C28;

A12-B7-C29;

A12-B7-C30;

A12-B7-C31;

A12-B7-C32;

A12-B7-C33;

A12-B7-C34;

A12-B7-C35;

A12-B7-C36;

A12-B7-C37;

A12-B7-C38;

A12-B7-C39;

A12-B7-C40;

A12-B7-C41;

A12-B7-C42;

A12-B7-C43;

Al2-B7-C44;

A12-B7-C45;

A12-B7-C46;

A12-B7-C47;

A12-B7-C48;

A12-B7-C49;

A12-B7-C50;

A12-B7-C51

A12-B7-C52;

A12-B7-C53;

A12-B7-C54;

A12-B7-C55;

A12-B7-C56;

A12-B7-C57;

A12-B7-C58;

A12-B7-C59;

A12-B7-C60;

A12-B7-C61;

A12-B7-C62;

A12-B7-C63;

A12-B7-C64;

A12-B7-C65;

A12-B7-C66;

A12-B7-C67;

A12-B7-C68;

A13-B7-C1;

A13-B7-C2;

A13-B7-C3;

A13-B7-C4;

A13-B7-C5;

A13-B7-C6;

A13-B7-C7;

A13-B7-C8;

A13-B7-C9;

A13-B7-C10;

A13-B7-C11;

A13-B7-C12;

A13-B7-C13;

A13-B7-C14;

A13-B7-C15;

-190 • 44 4 4 444

4 4 4 4 4

444 44 44 444

A13-B7-C16;

A13-B7-C17;

A13-B7-C18;

A13-B7-C19;

A13-B7-C20;

A13-B7-C21;

A13-B7-C22;

A13-B7-C23;

A13-B7-C24;

A13-B7-C25;

A13-B7-C26;

A13-B7-C27;

A13-B7-C28;

A13-B7-C29;

A13-B7-C30;

A13-B7-C31;

A13-B7-C32;

A13-B7-C33;

A13-B7-C34;

A13-B7-C35;

A13-B7-C36;

A13-B7-C37;

A13-B7-C38;

A13-B7-C39;

A13-B7-C40;

A13-B7-C41;

A13-B7-C42;

AND

A13-B7-C43;

A13-B7-C44;

A13-B7-C45;

A13-B7-C46;

A13-B7-C47;

A13-B7-C48;

A13-B7-C49;

A13-B7-C50;

A13-B7-C51;

A13-B7-C52;

A13-B7-C53;

A13-B7-C54;

A13-B7-C55;

A13-B7-C56;

A13-B7-C57;

A13-B7-C58;

A13-B7-C59;

A13-B7-C60;

A13-B7-C61;

A13-B7-C62;

A13-B7-C63;

A13-B7-C64;

A13-B7-C65;

A13-B7-C66;

A13-B7-C67;

A13-B7-C68;

A14-B7-C1;

A14-B7-C2;

A14-B7-C3;

A14-B7-C4;

A14-B7-C5;

A14-B7-C6;

A14-B7-C7;

A14-B7-C8;

A14-B7-C9;

A14-B7-C10;

A14-B7-C11;

A14-B7-C12;

A14-B7-C13;

A14-B7-C14;

A14-B7-C15;

A14-B7-C16;

A14-B7-C17;

A14-B7-C18;

A14-B7-C19;

A14-B7-C20;

A14-B7-C21;

A14-B7-C22;

A14-B7-C23;

A14-B7-C24;

A14-B7-C25;

A14-B7-C26;

A14-B7-C27;

A14-B7-C28;

A14-B7-C29;

A14-B7-C30;

A14-B7-C31;

A14-B7-C32;

A14-B7-C33;

A14-B7-C34;

A14-B7-C35;

A14-B7-C36;

A14-B7-C37;

A14-B7-C38;

A14-B7-C39;

A14-B7-C40;

44-B7-C41;

A14-B7-C42;

A14-B7-C43;

A14-B7-C44;

A14-B7-C45;

A14-B7-C46;

A14-B7-C47;

A14-B7-C48;

A14-B7-C49;

A14-B7-C50;

A14-B7-C51;

A14-B7-C52;

A14-B7-C53;

A14-B7-C54;

A14-B7-C55;

A14-B7-C56;

A14-B7-C57;

A14-B7-C58;

A14-B7-C59;

A14-B7-C60;

A14-B7-C61;

A14-B7-C62;

A14-B7-C63;

A14-B7-C64;

A14-B7-C65;

A14-B7-C66;

A14-B7-C67;

A14-B7-C68;

A15-B7-C1;

A15-B7-C2;

A15-B7-C3;

A15-B7-C4;

A15-B7-C5;

A15-B7-C6;

A15-B7-C7;

A15-B7-C8;

A15-B7-C9;

A15-B7-C10;

A15-B7-C11;

A15-B7-C12

A15-B7-C13;

A15-B7-C14;

A15-B7-C15;

A15-B7-C16;

A15-B7-C17;

A15-B7-C18;

A15-B7-C19;

A15-B7-C20;

A15-B7-C21;

A15-B7-C22;

A15-B7-C23;

A15-B7-C24;

A15-B7-C25;

A15-B7-C26;

A15-B7-C27;

A15-B7-C28;

A15-B7-C29;

A15-B7-C30;

A15-B7-C31;

A15-B7-C32;

A15-B7-C33;

A15-B7-C34;

A15-B7-C35;

A15-B7-C36;

A15-B7-C37;

A15-B7-C38;

A15-B7-C39;

A15-B7-C40;

A15-B7-C41;

A15-B7-C42;

A15-B7-C43;

A15-B7-C44;

- 191 -

A15-B7-C45; A16-B7-C10; A16-B7-C43; A17-B7-C8; A17-B7-C41; A15-B7-C46; A16-B7-C11; A16-B7-C44; A17-B7-C9; A17-B7-C42; A15-B7-C47; A16-B7-C12; A16-B7-C45; A17-B7-C10; A17-B7-C43; A15-B7-C48; A16-B7-C13; A16-B7-C46; A17-B7-C11; A17-B7-C44; A15-B7-C49; A16-B7-C14; A16-B7-C47; A17-B7-C12; A17-B7-C45; A15-B7-C50; A16-B7-C15; A16-B7-C48; A17-B7-C13; A17-B7-C46; A15-B7-C51; A16-B7-C16; A16-B7-C49; A17-B7-C14; A17-B7-C47; A15-B7-C52; A16-B7-C17; A16-B7-C50; A17-B7-C15; A17-B7-C48; A15-B7-C53; A16-B7-C18; A16-B7-C51; A17-B7-C16; A17-B7-C49; A15-B7-C54; A16-B7-C19; A16-B7-C52; A17-B7-C17; A17-B7-C50; A15-B7-C55; A16-B7-C20; A16-B7-C53; A17-B7-C18; A17-B7-C51; A15-B7-C56; A16-B7-C21; A16-B7-C54; A17-B7-C19; A17-B7-C52; A15-B7-C57; A16-B7-C22; A16-B7-C55; A17-B7-C20; A17-B7-C53; A15-B7-C58; A16-B7-C23; A16-B7-C56; A17-B7-C21; A17-B7-C54; A15-B7-C59; A16-B7-C24; A16-B7-C57; A17-B7-C22; A17-B7-C55; A15-B7-C60; A16-B7-C25; A16-B7-C58; A17-B7-C23; A17-B7-C56; A15-B7-C61; A16-B7-C26; A16-B7-C59; A17-B7-C24; A17-B7-C57; A15-B7-C62; A16-B7-C27; A16-B7-C60; A17-B7-C25; A17-B7-C58; A15-B7-C63; A16-B7-C28; A16-B7-C61; A17-B7-C26; A17-B7-C59; A15-B7-C64; A16-B7-C29; A16-B7-C62; A17-B7-C27; A17-B7-C60; A15-B7-C65; A16-B7-C30; A16-B7-C63; A17-B7-C28; A17-B7-C61; A15-B7-C66; A16-B7-C31; A16-B7-C64; A17-B7-C29; A17-B7-C62; A15-B7-C67; A16-B7-C32; A16-B7-C65; A17-B7-C30; A17-B7-C63; A15-B7-C68; A16-B7-C33; A16-B7-C66; A17-B7-C31; A17-B7-C64; A16-B7-C1; A16-B7-C34; A16-B7-C67; A17-B7-C32; A17-B7-C65; A16-B7-C2; A16-B7-C35; A16-B7-C68; A17-B7-C33; Al7-B7-C66; A16-B7-C3; A16-B7-C36; A17-B7-C1; A17-B7-C34; A17-B7-C67; A16-B7-C4; A16-B7-C37; A17-B7-C2; A17-B7-C35; A17-B7-C68; A16-B7-C5; A16-B7-C38; A17-B7-C3; A17-B7-C36; A18-B7-C1; A16-B7-C6; A16-B7-C39; A17-B7-C4; A17-B7-C37; A18-B7-C2; A16-B7-C7; A16-B7-C40; A17-B7-C5; A17-B7-C38; A18-B7-C3; A16-B7-C8; A16-B7-C41; A17-B7-C6; A17-B7-C39; A18-B7-C4; A16-B7-C9; A16-B7-C42; A17-B7-C7; A17-B7-C40; A18-B7-C5;

• 4 4

49 9 4

9 4 9 9 5

4 4 4 9

4 4 4 4 4

4

4

-1929 · ·

A18-B7-C6;

A18-B7-C7;

A18-B7-C8;

A18-B7-C9;

A18-B7-C10;

A18-B7-C11;

A18-B7-C12;

A18-B7-C13;

A18-B7-C14;

A18-B7-C15;

A18-B7-C16;

A18-B7-C17;

A18-B7-C18;

A18-B7-C19;

A18-B7-C20;

A18-B7-C21;

A18-B7-C22;

A18-B7-C23;

A18-B7-C24;

A18-B7-C25;

A18-B7-C26;

A18-B7-C27;

A18-B7-C28;

A18-B7-C29;

A18-B7-C30;

A18-B7-C31;

A18-B7-Cl2;

A18-B7-C33;

A18-B7-C34;

A18-B7-C35;

A18-B7-C36;

A18-B7-C37;

A18-B7-C38;

A18-B7-C39;

A18-B7-C40;

A18-B7-C41;

A18-B7-C42;

A18-B7-C43;

A18-B7-C44;

A18-B7-C45;

A18-B7-C46;

A18-B7-C47;

A18-B7-C48;

A18-B7-C49;

A18-B7-C50;

A18-B7-C51;

A18-B7-C52;

A18-B7-C53;

A18-B7-C54;

A18-B7-C55;

A18-B7-C56;

A18-B7-C57;

A18-B7-C58;

A18-B7-C59;

A18-B7-C60;

A18-B7-C61;

A18-B7-C62;

A18-B7-C63;

A18-B7-C64;

A18-B7-C65;

A18-B7-C66;

A18-B7-C67;

A18-B7-C68;

A19-B7-C1;

A19-B7-C2;

A19-B7-C3;

A19-B7-C4;

A19-B7-C5;

A19-B7-C6;

A19-B7-C7;

A19-B7-C8;

A19-B7-C9;

A19-B7-C10;

A19-B7-C11;

A19-B7-C12;

A19-B7-C13;

A19-B7-C14;

A19-B7-C15;

A19-B7-C16;

A19-B7-C17;

A19-B7-C18;

A19-B7-C19;

A19-B7-C20;

A19-B7-C21;

A19-B7-C22;

A19-B7-C23;

A19-B7-C24;

A19-B7-C25;

A19-B7-C26;

A19-B7-C27;

A19-B7-C28;

A19-B7-C29;

A19-B7-C30;

A19-B7-C31;

A19-B7-C32;

A19-B7-C33;

A19-B7-C34;

A19-B7-C35;

A19-B7-C36;

A19-B7-C37;

A19-B7-C38;

A19-B7-C39;

A19-B7-C40;

A19-B7-C41;

A19-B7-C42;

A19-B7-C43;

A19-B7-C44;

A19-B7-C45;

A19-B7-C46;

A19-B7-C47;

A19-B7-C48;

A19-B7-C49;

A19-B7-C50;

A19-B7-C51;

A19-B7-C52;

A19-B7-C53;

A19-B7-C54;

A19-B7-C55;

A19-B7-C56;

A19-B7-C57;

A19-B7-C58;

A19-B7-C59;

A19-B7-C60;

A19-B7-C61;

A19-B7-C62;

A19-B7-C63;

A19-B7-C64;

A19-B7-C65;

A19-B7-C66;

A19-B7-C67;

A19-B7-C68;

A20-B7-C1;

A20-B7-C2;

A20-B7-C3;

A20-B7-C4;

A20-B7-C5;

A20-B7-C6;

A20-B7-C7;

A20-B7-C8;

A20-B7-C9;

A20-B7-C10;

A20-B7-C11;

A20-B7-C12;

A20-B7-C13;

A20-B7-C14;

A20-B7-C15;

A20-B7-C16;

A20-B7-C17;

A20-B7-C18;

A20-B7-C19;

A20-B7-C20;

A20-B7-C21;

A20-B7-C22;

A20-B7-C23;

A20-B7-C24;

A20-B7-C25;

A20-B7-C26;

A20-B7-C27;

A20-B7-C28;

A20-B7-C29;

A20-B7-C30;

A20-B7-C31;

A20-B7-C32;

A20-B7-C33;

A20-B7-C34;

A20-B7-C35;

A20-B7-C36;

A20-B7-C37;

A20-B7-C38;

A20-B7-C39;

A20-B7-C40;

A20-B7-C41;

A20-B7-C42;

A20-B7-C43;

A20-B7-C44;

A20-B7-C45;

A20-B7-C46;

A20-B7-C47;

A20-B7-C48;

A20-B7-C49;

A20-B7-C50;

A20-B7-C51;

A20-B7-C52;

A20-B7-C53;

A20-B7-C54;

A20-B7-C55;

A20-B7-C56;

A20-B7-C57;

A20-B7-C58;

A20-B7-C59;

A20-B7-C60;

A20-B7-C61;

A20-B7-C62;

A20-B7-C63;

A20-B7-C64;

A20-B7-C65;

A20-B7-C66;

A20-B7-C67;

-193 - • ·· • · · ♦ • ·· • ♦ · • · · · · · ♦ · ·· · ♦ · ·· · · ·· • · · · · · * ·· · · t · ·· ··· ·· «·· A20-B7-C68; A21-B7-C33; A21-B7-C66; A22-B7-C31; A21-B7-C1; A21-B7-C34; A21-B7-C67; A22-B7-C32; A21-B7-C2; A21-B7-C35; A21-B7-C68; A22-B7-C33; A21-B7-C3; A21-B7-C36; A22-B7-C1; A22-B7-C34; A21-B7-C4; A21-B7-C37; A22-B7-C2; A22-B7-C35; A21-B7-C5; A21-B7-C38; A22-B7-C3; A22-B7-C36; A21-B7-C6; A21-B7-C39; A22-B7-C4; A22-B7-C37; A21-B7-C7; A21-B7-C40; A22-B7-C5; A22-B7-C38; A21-B7-C8; A21-B7-C41; A22-B7-C6; A22-B7-C39; A21-B7-C9; A21-B7-C42; A22-B7-C7; A22-B7-C40; A21-B7-C10; A21-B7-C43; A22-B7-C8; A22-B7-C41; A21-B7-C11; A21-B7-C44; A22-B7-C9; A22-B7-C42; A21-B7-C12; A21-B7-C45; A22-B7-C10; A22-B7-C43; A21-B7-C13; A21-B7-C46; A22-B7-C11; A22-B7-C44; A21-B7-C14; A21-B7-C47; A22-B7-C12; A22-B7-C45; A21-B7-C15; A21-B7-C48; A22-B7-C13; A22-B7-C46; A21-B7-C16; A21-B7-C49; A22-B7-C14; A22-B7-C47; A21-B7-C17; A21-B7-C50; A22-B7-C15; A22-B7-C48; A21-B7-C18; A21-B7-C51; A22-B7-C16; A22-B7-C49; A21-B7-C19; A21-B7-C52; A22-B7-C17; A22-B7-C50; A21-B7-C20; A21-B7-C53; A22-B7-C18; A22-B7-C51; A21-B7-C21; A21-B7-C54; A22-B7-C19; A22-B7-C52; A21-B7-C22; A21-B7-C55; A22-B7-C20; A22-B7-C53; A21-B7-C23; A21-B7-C56; A22-B7-C21; A22-B7-C54; A21-B7-C24; A21-B7-C57; A22-B7-C22; A22-B7-C55; A21-B7-C25; A21-B7-C58; A22-B7-C23; A22-B7-C56; A21-B7-C26; A21-B7-C59; A22-B7-C24; A22-B7-C57; A21-B7-C27; A21-B7-C60; A22-B7-C25; A22-B7-C58; A21-B7-C28; A21-B7-C61; A22-B7-C26; A22-B7-C59; A21-B7-C29; A21-B7-C62; A22-B7-C27; A22-B7-C60; A21-B7-C30; A21-B7-C63; A22-B7-C28; A22-B7-C61; A21-B7-C31; A21-B7-C64; A22-B7-C29; A22-B7-C62; A21-B7-C32; A21-B7-C65; A22-B7-C30; A22-B7-C63;

· · * · «* * * · · ·

- 194 · · · · · · · ···

A22-B7-C64;

A22-B7-C65;

A22-B7-C66;

A22-B7-C67;

A22-B7-C68;

A23-B7-C1;

A23-B7-C2;

A23-B7-C3;

A23-B7-C4;

A23-B7-C5;

A23-B7-C6;

A23-B7-C7;

A23-B7-C8;

A23-B7-C9;

A23-B7-C10;

A23-B7-C11;

A23-B7-C12;

A23-B7-C13;

A23-B7-C14;

A23-B7-C15;

A23-B7-C16;

A23-B7-C17;

A23-B7-C18;

A23-B7-C19;

A23-B7-C20;

A23-B7-C21;

A23-B7-C22;

AND

A23-B7-C23;

A23-B7-C24;

A23-B7-C25;

A23-B7-C26;

A23-B7-C27;

A23-B7-C28;

A23-B7-C29;

A23-B7-C30;

A23-B7-C31;

A23-B7-C32;

A23-B7-C33;

A23-B7-C34;

A23-B7-C35;

A23-B7-C36;

A23-B7-C37;

A23-B7-C38;

A23-B7-C39;

A23-B7-C40;

A23-B7-C41;

A23-B7-C42;

A23-B7-C43;

A23-B7-C44;

A23-B7-C45;

A23-B7-C46;

A23-B7-C47;

A23-B7-C48;

A23-B7-C49;

A23-B7-C50;

A23-B7-C51;

A23-B7-C52;

A23-B7-C53;

A23-B7-C54;

A23-B7-C55;

A23-B7-C56;

A23-B7-C57;

A23-B7-C58;

A23-B7-C59;

A23-B7-C60;

A23-B7-C61;

A23-B7-C62;

A23-B7-C63;

A23-B7-C64;

A23-B7-C65;

A23-B7-C66;

A23-B7-C67;

A23-B7-C68;

A24-B7-C1;

A24-B7-C2;

A24-B7-C3;

A24-B7-C4;

A24-B7-C5;

A24-B7-C6;

A24-B7-C7;

A24-B7-C8;

A24-B7-C9;

A24-B7-C10;

A24-B7-C11;

A24-B7-C12;

A24-B7-C13;

A24-B7-C14;

A24-B7-C15;

A24-B7-C16;

A24-B7-C17;

A24-B7-C18;

A24-B7-C19;

A24-B7-C20;

A24-B7-C21;

A24-B7-C22;

A24-B7-C23;

A24-B7-C24;

A24-B7-C25;

A24-B7-C26;

A24-B7-C27;

A24-B7-C28;

A24-B7-C29;

A24-B7-C30;

A24-B7-C31;

A24-B7-C32;

A24-B7-C33;

A24-B7-C34;

A24-B7-C35;

A24-B7-C36;

A24-B7-C37;

A24-B7-C38;

A24-B7-C39;

A24-B7-C40;

A24-B7-C41;

A24-B7-C42;

A24-B7-C43;

A24-B7-C44;

A24-B7-C45;

A24-B7-C46;

A24-B7-C47;

A24-B7-C48;

A24-B7-C49;

A24-B7-C50;

A24-B7-C51;

A24-B7-C52;

A24-B7-C53;

A24-B7-C54;

A24-B7-C55;

A24-B7-C56;

A24-B7-C57;

A24-B7-C58;

A24-B7-C59;

A24-B7-C60

A24-B7-C60:

A24-B7-C61:

A24-B7-C63;

A24-B7-C64;

A24-B7-C65;

A24-B7-C66;

A24-B7-C67;

A24-B7-C68;

A25-B7-C1;

A25-B7-C2;

A25-B7-C3;

A25-B7-C4;

A25-B7-C5;

A25-B7-C6;

A25-B7-C7;

A25-B7-C8;

A25-B7-C9;

A25-B7-C10;

A25-B7-C11;

A25-B7-C12;

A25-B7-C13;

A25-B7-C14;

A25-B7-C15;

A25-B7-C16;

A25-B7-C17;

A25-B7-C18;

A25-B7-C19;

A25-B7-C20;

A25-B7-C21;

A25-B7-C22;

A25-B7-C23;

A25-B7-C24;

-195 9 9 9 9 9 9 9

9 9 · 9 9 9 99 • 9 9 9 9 99 99

A25-B7-C25;

A25-B7-C26;

A25-B7-C27;

A25-B7-C28;

A25-B7-C29;

A25-B7-C30;

A25-B7-C31;

A25-B7-C32;

A25-B7-C33;

A25-B7-C34;

A25-B7-C35;

A25-B7-C36;

A25-B7-C37;

A25-B7-C38;

A25-B7-C39;

A25-B7-C40;

A25-B7-C41;

A25-B7-C42;

A25-B7-C43;

A25-B7-C44;

A25-B7-C45;

A25-B7-C46;

A25-B7-C47;

A25-B7-C48;

A25-B7-C49;

A25-B7-C50;

A25-B7 ₁ C51;

A25-B7-C52;

A25-B7-C53;

A25-B7-C54;

A25-B7-C55;

A25-B7-C56;

A25-B7-C57;

A25-B7-CS8;

A25-B7-C59;

A25-B7-C60;

A25-B7-C61;

A25-B7-C62;

A25-B7-C63;

A25-B7-C64;

A25-B7-C65;

A25-B7-C66;

A25-B7-C67;

A25-B7-C68;

A26-B7-C1;

A26-B7-C2;

A26-B7-C3;

A26-B7-C4;

A26-B7-C5;

A26-B7-C6;

A26-B7-C7;

A26-B7-C8;

A26-B7-C9;

A26-B7-C10;

A26-B7-C11;

A26-B7-C12;

A26-B7-C13;

A26-B7-C14;

A26-B7-C15;

A26-B7-C16;

A26-B7-C17;

A26-B7-C18;

A26-B7-C19;

A26-B7-C20;

A26-B7-C21;

A26-B7-C22;

A26-B7-C23;

A26-B7-C24;

A26-B7-C25;

A26-B7-C26;

A26-B7-C27;

A26-B7-C28;

A26-B7-C29;

A26-B7-C30;

A26-B7-C31;

A26-B7-C32;

A26-B7-C33;

A26-B7-C34;

A26-B7-C35;

A26-B7-C36;

A26-B7-C37;

A26-B7-C38;

A26-B7-C39;

A26-B7-C40;

A26-B7-C41;

A26-B7-C42;

A26-B7-C43;

A26-B7-C44;

A26-B7-C45;

A26-B7-C46;

A26-B7-C47;

A26-B7-C48;

A26-B7-C49;

A26-B7-C50;

A26-B7-C51;

A26-B7-C52;

A26-B7-CS3;

A26-B7-C54;

A26-B7-C55;

A26-B7-C56;

A26-B7-C57;

A26-B7-C58;

A26-B7-C59;

A26-B7-C60;

A26-B7-C61;

A26-B7-C62;

A26-B7-C63;

A26-B7-C64;

A26-B7-C65;

A26-B7-C66;

A26-B7-C67;

A26-B7-C68;

A27-B7-C1;

A27-B7-C2;

A27-B7-C3;

A27-B7-C4;

A27-B7-C5;

A27-B7-C6;

A27-B7-C7;

A27-B7-C8;

A27-B7-C9;

A27-B7-C10;

A27-B7-C11;

A27-B7-C12;

A27-B7-C13;

A27-B7-C14;

A27-B7-C15;

A27-B7-C16;

A27-B7-C17;

A27-B7-C18;

A27-B7-C19;

A27-B7-C20;

A27-B7-C21

A27-B7-C22

A27-B7-C22:

A27-B7-C24;

A27-B7-C25;

A27-B7-C26;

A27-B7-C27;

A27-B7-C28;

A27-B7-C29;

A27-B7-C30;

A27-B7-C31;

A27-B7-C32;

A27-B7-C33;

A27-B7-C34;

A27-B7-C35;

A27-B7-C36;

A27-B7-C37;

A27-B7-C38;

A27-B7-C39;

A27-B7-C40;

A27-B7-C41;

A27-B7-C42;

A27-B7-C43;

A27-B7-C44;

A27-B7-C45;

A27-B7-C46;

A27-B7-C47;

A27-B7-C48;

A27-B7-C49;

A27-B7-CS0;

A27-B7-C51;

A27-B7-C52;

A27-B7-C53;

• · ·

196A27-B7-C54;

A27-B7-C55;

A27-B7-C56;

A27-B7-C57;

A27-B7-C58;

A27-B7-C59;

A27-B7-C60;

A27-B7-C61;

A27-B7-C62;

A27-B7-C63;

A27-B7-C64;

A27-B7-C65;

A27-B7-C66;

A27-B7-C67;

A27-B7-C68;

A28-B7-C1;

A28-B7-C2;

A28-B7-C3;

A28-B7-C4;

A28-B7-C5;

A28-B7-C6;

A28-B7-C7;

A28-B7-C8;

A28-B7-C9;

A28-B7-C10;

A28-B7-C11;

A28-B7-C12;

A28-B7-C13;

A28-B7-C14;

A28-B7-C15;

A28-B7-C16;

A28-B7-C17;

A28-B7-C18;

A28-B7-C19;

A28-B7-C20;

A28-B7-C21;

A28-B7-C22;

A28-B7-C23;

A28-B7-C24;

A28-B7-C25;

A28-B7-C26;

A28-B7-C27;

A28-B7-C28;

A28-B7-C29;

A28-B7-C30;

A28-B7-C31;

A28-B7-C32;

A28-B7-C33;

A28-B7-C34;

A28-B7-C35;

A28-B7-C36;

A28-B7-C37;

A28-B7-C38;

A28-B7-C39;

A28-B7-C40;

A28-B7-C41;

A28-B7-C42;

A28-B7-C43;

A28-B7-C44;

A28-B7-C45;

A28-B7-C46;

A28-B7-C47;

A28-B7-C48;

A28-B7-C49;

A28-B7-C50;

A28-B7-C51;

A28-B7-C52;

A28-B7-C53;

A28-B7-C54;

A28-B7-C55;

A28-B7-C56;

A28-B7-C57;

A28-B7-C58;

A28-B7-C59;

A28-B7-C60;

A28-B7-C61;

A28-B7-C62;

A28-B7-C63;

A28-B7-C64;

A28-B7-C65;

A28-B7-C66;

A28-B7-C67;

A28-B7-C68;

A29-B7-C1;

A29-B7-C2;

A29-B7-C3;

A29-B7-C4;

A29-B7-C5;

A29-B7-C6;

A29-B7-C7;

A29-B7-C8;

A29-B7-C9;

A29-B7-C10;

A29-B7-C11;

A29-B7-C12;

A29-B7-C13;

A29-B7-C14;

A29-B7-C15;

A29-B7-C16;

A29-B7-C17;

A29-B7-C18;

A29-B7-C19;

A29-B7-C20;

A29-B7-C21;

A29-B7-C22;

A29-B7-C23;

A29-B7-C24;

A29-B7-C25;

A29-B7-C26;

A29-B7-C27;

A29-B7-C28;

A29-B7-C29;

A29-B7-C30;

A29-B7-C31;

A29-B7-C32;

A29-B7-C33;

A29-B7-C34;

A29-B7-C35;

A29-B7-C36;

A29-B7-C37;

A29-B7-C38;

A29-B7-C39;

A29-B7-C40;

A29-B7-C41;

A29-B7-C42;

A29-B7-C43;

A29-B7-C44;

A29-B7-C45;

A29-B7-C46;

A29-B7-C47;

A29-B7-C48;

A29-B7-C49;

A29-B7-C50;

A29-B7-C51;

A29-B7-C52;

A29-B7-C53;

A29-B7-C54;

A29-B7-C55;

A29-B7-C56;

A29-B7-C57;

A29-B7-C58;

A29-B7-C59;

A29-B7-C60;

A29-B7-C61;

A29-B7-C62;

A29-B7-C63;

A29-B7-C64;

A29-B7-C65;

A29-B7-C66;

A29-B7-C67;

A29-B7-C68;

A30-B7-C1;

A30-B7-C2;

A30-B7-C3;

A30-B7-C4;

A30-B7-C5;

A30-B7-C6;

A30-B7-C7;

A30-B7-C8;

A30-B7-C9;

A30-B7-C10;

A30-B7-C11;

A30-B7-C12;

A30-B7-C13;

A30-B7-C14;

· · · · · · · · · · · · · · · · · · · · · · · · · · ·

-197 ··· ··· ··· ·· ···

A30-B7-C15;

A30-B7-C16;

A30-B7-C17;

A30-B7-C18;

A30-B7-C19;

A30-B7-C20;

A30-B7-C21;

A30-B7-C22;

A30-B7-C23;

A30-B7-C24;

A30-B7-C25;

A30-B7-C26;

A30-B7-C27;

A30-B7-C28;

A30-B7-C29;

A30-B7-C30;

A30-B7-C31;

A30-B7-C32;

A30-B7-C33;

A30-B7-C34;

A30-B7-C35;

A30-B7-C36;

A30-B7-C37;

A30-B7-C38;

A30-B7-C39;

A30-B7-C40;

A30-B7-C41;

A30-B7-C42;

A30-B7-C43;

A30-B7-C44;

A30-B7-C45;

A30-B7-C46;

A30-B7-C47;

A30-B7-C48;

A30-B7-C49;

A3O-B7-C50;

A30-B7-C51;

A30-B7-C52;

A30-B7-C53;

A30-B7-C54;

A30-B7-C55;

A30-B7-CS6;

A30-B7-C57;

A30-B7-C58;

A30-B7-C59;

A30-B7-C60;

A30-B7-C61;

A30-B7-C62;

A30-B7-C63;

A30-B7-C64;

A30-B7-C65;

A30-B7-C66;

A30-B7-C67;

A30-B7-C68;

A31-B7-C1;

A31-B7-C2;

A31-B7-C3;

A31-B7-C4;

A31-B7-C5;

A31-B7-C6;

A31-B7-C7;

A31-B7-C8;

A31-B7-C9;

A31-B7-C10;

A31-B7-C11;

A31-B7-C12;

A31-B7-C13;

A31-B7-C14;

A31-B7-C15;

A31-B7-C16;

A31-B7-C17;

A31-B7-C18;

A31-B7-C19;

A31-B7-C20;

A31-B7-C21;

A31-B7-C22;

A31-B7-C23;

A31-B7-C24;

A31-B7-C25;

A31-B7-C26;

A31-B7-C27;

A31-B7-C28;

A31-B7-C29;

A31-B7-C30;

A31-B7-C31;

A31-B7-C32;

A31-B7-C33;

A31-B7-C34;

A31-B7-C35;

A31-B7-C36;

A31-B7-C37;

A31-B7-C38;

A31-B7-C39;

A31-B7-C40;

A31-B7-C41;

A31-B7-C42;

A31-B7-C43;

A31-B7-C44;

A31-B7-C45;

A31-B7-C46;

A31-B7-C47;

A31-B7-C48;

A31-B7-C49;

A31-B7-C50;

A31-B7-C51;

A31-B7-C52;

A31-B7-C53;

A31-B7-C54;

A31-B7-C55;

A31-B7-C56;

A31-B7-C57;

A31-B7-C58;

A31-B7-C59;

A31-B7-C60;

A31-B7-C61;

A31-B7-C62;

A31-B7-C63;

A31-B7-C64;

A31-B7-C65;

A31-B7-C66;

A31-B7-C67;

A3I-B7-C68;

A32-B7-C1;

A32-B7-C2;

A32-B7-C3;

A32-B7-C4;

A32-B7-C5;

A32-B7-C6;

A32-B7-C7;

A32-B7-C8;

A32-B7-C9;

A32-B7-C10;

A32-B7-CU;

A32-B7-C12;

A32-B7-C13;

A32-B7-C14;

A32-B7-C15;

A32-B7-C16;

A32-B7-C17;

A32-B7-C18;

A32-B7-C19;

A32-B7-C20;

A32-B7-C21;

A32-B7-C22;

A32-B7-C23;

A32-B7-C24;

A32-B7-C25;

A32-B7-C26;

A32-B7-C27;

A32-B7-C28;

A32-B7-C29;

32 32 -B7-C30;

A32-B7-C31;

A32-B7-C32;

A32-B7-C33;

A32-B7-C34;

A32-B7-C35;

A32-B7-C36;

A32-B7-C37;

A32-B7-C38;

A32-B7-C39;

A32-B7-C40;

A32-B7-C41;

A32-B7-C42;

A32-B7-C43;

• ·· ♦ · · · · · · · · · ·

- 198 ··· ··· ··· ·· ·· ··· ·· ·

A32-B7-C44; A33-B7-C9; A33-B7-C42; A34-B7-C7; A34-B7-C40; A32-B7-C45; A33-B7-C10; A33-B7-C43; A34-B7-C8; A34-B7-C41; A32-B7-C46; A33-B7-C11; A33-B7-C44; A34-B7-C9; A34-B7-C42; A32-B7-C47; A33-B7-C12; A33-B7-C45; A34-B7-C10; A34-B7-C43; A32-B7-C48; A33-B7-C13; A33-B7-C46; A34-B7-C11; A34-B7-C44; A32-B7-C49; A33-B7-C14; A33-B7-C47; A34-B7-C12; A34-B7-C45; A32-B7-C50; A33-B7-C15; A33-B7-C48; A34-B7-C13; A34-B7-C46; A32-B7-C51; A33-B7-C16; A33-B7-C49; A34-B7-C14; A34-B7-C47; A32-B7-C52; A33-B7-C17; A33-B7-C50; A34-B7-C15; A34-B7-C48; A32-B7-C53; A33-B7-C18; A33-B7-C51; A34-B7-C16; A34-B7-C49; A32-B7-C54; A33-B7-C19; A33-B7-C52; A34-B7-C17; A34-B7-C50; A32-B7-C55; A33-B7-C20; A33-B7-C53; A34-B7-C18; A34-B7-C51; A32-B7-C56; A33-B7-C21; A33-B7-C54; A34-B7-C19; A34-B7-C52; A32-B7-C57; A33-B7-C22; A33-B7-C55; A34-B7-C20; A34-B7-C53; A32-B7-C58; A33-B7-C23; A33-B7-C56; A34-B7-C21; A34-B7-C54; A32-B7-C59; A33-B7-C24; A33-B7-C57; A34-B7-C22; A34-B7-C55; A32-B7-C60; A33-B7-C25; A33-B7-C58; A34-B7-C23; A34-B7-C56; A32-B7-C61; A33-B7-C26; A33-B7-C59; A34-B7-C24; A34-B7-C57; A32-B7-C62; A33-B7-C27; A33-B7-C60; A34-B7-C25; A34-B7-C58; A32-B7-C63; A33-B7-C28; A33-B7-C61; A34-B7-C26; A34-B7-C59; A32-B7-C64; A33-B7-C29; A33-B7-C62; A34-B7-C27; A34-B7-C60; A32-B7-C65; A33-B7-C30; A33-B7-C63; A34-B7-C28; A34-B7-C61; A32-B7-C66; A33-B7-C31; A33-B7-C64; A34-B7-C29; A34-B7-C62; A32-B7-C67; A33-B7-C32; A33-B7-C65; A34-B7-C30; A34-B7-C63; A32-B7-C68; A33-B7-C33; A33-B7-C66; A34-B7-C31; A34-B7-C64; A33-B7-C1; A33-B7-C34; A33-B7-C67; A34-B7-C32; A34-B7-C65; A33-B7-C2; A33-B7-C35; A33-B7-C68; A34-B7-C33; A34-B7-C66; A33-B7-C3; A33-B7-C36; A34-B7-C1; A34-B7-C34; A34-B7-C67; A33-B7-C4; A33-B7-C37; A34-B7-C2; A34-B7-C35; A34-B7-C68; A33-B7-C5; A33-B7-C38; A34-B7-C3; A34-B7-C36; A35-B7-C1; A33-B7-C6; A33-B7-C39; A34-B7-C4; A34-B7-C37; A35-B7-C2; A33-B7-C7; A33-B7-C40; A34-B7-C5; A34-B7-C38; A35-B7-C3; A33-B7-C8; A33-B7-C41; A34-B7-C6; A34-B7-C39; A35-B7-C4;

- 199 Φ Φ · 199 199 199 199 199 199 199 199 199 199 199 199 199 199 199 199 199 199 199

A35-B7-C5;

A35-B7-C6;

A35-B7-C7;

A35-B7-C8;

A35-B7-C9;

A35-B7-C10;

A35-B7-C11;

A35-B7-C12;

A35-B7-C13;

A35-B7-C14;

A35-B7-C15;

A35-B7-C16;

A35-B7-C17;

A35-B7-C18;

A35-B7-C19;

A35-B7-C20;

A35-B7-C21;

A35-B7-C22;

A35-B7-C23;

A35-B7-C24;

A35-B7-C25;

A35-B7-C26;

A35-B7-C27;

A35-B7-C28;

A35-B7-C29;

A35-B7-C30;

A35-B7-C31;

A35-B7-C32;

A35-B7-C33;

A35-B7-C34;

A35-B7-C35;

A35-B7-C36;

A35-B7-C37;

A35-B7-C38;

A35-B7-C39;

A35-B7-C40;

A35-B7-C41;

A35-B7-C42;

A35-B7-C43;

A35-B7-C44;

A35-B7-C45;

A35-B7-C46;

A35-B7-C47;

A35-B7-C48;

A35-B7-C49;

A35-B7-C50;

A35-B7-C51;

A35-B7-C52;

A35-B7-C53;

A35-B7-C54;

A35-B7-C55;

A35-B7-C56;

A35-B7-C57;

A35-B7-C58;

A35-B7-C59;

A35-B7-C60;

A35-B7-C61;

A35-B7-C62;

A35-B7-C63;

A35-B7-C64;

A35-B7-C65;

A35-B7-C66;

A35-B7-C67;

A35-B7-C68;

A36-B7-C1;

A36-B7-C2;

A36-B7-C3;

A36-B7-C4;

A36-B7-C5;

A36-B7-C6;

A36-B7-C7;

A36-B7-C8;

A36-B7-C9;

A36-B7-C10;

A36-B7-C11;

A36-B7-C12;

A36-B7-C13;

A36-B7-C14;

A36-B7-C15;

A36-B7-C16;

A36-B7-C17;

A36-B7-C18;

A36-B7-C19;

A36-B7-C20;

A36-B7-C21;

A36-B7-C22;

A36-B7-C23;

A36-B7-C24;

A36-B7-C25;

A36-B7-C26;

A36-B7-C27;

A36-B7-C28;

A36-B7-C29;

A36-B7-C30;

A36-B7-C31;

A36-B7-C32;

A36-B7-C33;

A36-B7-C34;

A36-B7-C35;

A36-B7-C36;

A36-B7-C37;

A36-B7-C38;

A36-B7-C39;

A36-B7-C40;

A36-B7-C41;

A36-B7-C42;

A36-B7-C43;

A36-B7-C44;

A36-B7-C45;

A36-B7-C46;

A36-B7-C47;

A36-B7-C48;

A36-B7-C49;

A36-B7-C50;

A36-B7-C51;

A36-B7-C52;

A36-B7-C53;

A36-B7-C54;

A36-B7-C55;

A36-B7-C56;

A36-B7-C57;

A36-B7-C58;

A36-B7-CS9;

A36-B7-C60;

A36-B7-C61;

A36-B7-C62;

A36-B7-C63;

A36-B7-C64;

A36-B7-C65;

A36-B7-C66;

A36-B7-C67;

A36-B7-C68;

A37-B7-C1;

A37-B7-C2;

A37-B7-C3;

A37-B7-C4;

A37-B7-C5;

A37-B7-C6;

A37-B7-C7;

A37-B7-C8;

A37-B7-C9;

A37-B7-C10;

A37-B7-C11;

A37-B7-C12;

A37-B7-C13;

A37-B7-C14;

A37-B7-C15;

A37-B7-C16;

A37-B7-C17;

A37-B7-C18;

A37-B7-C19;

37 37 -B7-C20;

A37-B7-C21;

A37-B7-C22;

A37-B7-C23;

A37-B7-C24;

A37-B7-C2S;

A37-B7-C26;

A37-B7-C27;

A37-B7-C28;

A37-B7-C29;

A37-B7-C30;

A37-B7-C31;

A37-B7-C32;

A37-B7-C33;

9 9 9 9 9 9 9 9 9 9 9 9

999 · · 99 9)

-200 ·· 9 • 9 99 • 99

9 9 9

9 9

999

A37-B7-C34;

A37-B7-C35;

A37-B7-C36;

A37-B7-C37;

A37-B7-C38;

A37-B7-C39;

A37-B7-C40;

A37-B7-C41;

A37-B7-C42;

A37-B7-C43;

A37-B7-C44;

A37-B7-C45;

A37-B7-C46;

A37-B7-C47;

A37-B7-C48;

A37-B7-C49;

A37-B7-C50;

A37-B7-C51;

A37-B7-CS2;

A37-B7-C53;

A37-B7-C54;

A37-B7-C55;

A37-B7-C56;

A37-B7-C57;

A37-B7-C58;

A37-B7-C59;

A37-B7-C60;

A37-B7-C61;

A37-B7-C62;

A37-B7-C63;

A37-B7-C64;

A37-B7-C65;

A37-B7-C66;

A37-B7-C67;

A37-B7-C68;

A38-B7-C1;

A38-B7-C2;

A38-B7-C3;

A38-B7-C4;

A38-B7-C5;

A38-B7-C6;

A38-B7-C7;

A38-B7-C8;

A38-B7-C9;

A38-B7-C10;

A38-B7-C11;

A38-B7-C12;

A38-B7-C13;

A38-B7-C14;

A38-B7-C15;

A38-B7-C16;

A38-B7-C17;

A38-B7-C18;

A38-B7-C19;

A38-B7-C20;

A38-B7-C21;

A38-B7-C22;

A38-B7-C23;

A38-B7-C24;

A38-B7-C25;

A38-B7-C26;

A38-B7-C27;

A38-B7-C28;

A38-B7-C29;

A38-B7-C30;

A38-B7-C31;

A38-B7-C32;

A38-B7-C33;

A38-B7-C34;

A38-B7-C35;

A38-B7-C36;

A38-B7-C37;

A38-B7-C38;

A38-B7-C39;

A38-B7-C40;

A38-B7-C41;

A38-B7-C42;

A38-B7-C43;

A38-B7-C44;

A38-B7-C45;

A38-B7-C46;

A38-B7-C47;

A38-B7-C48;

A38-B7-C49;

A38-B7-C50;

A38-B7-C51;

A38-B7-C52;

A38-B7-C53;

A38-B7-C54;

A38-B7-C55;

A38-B7-C56;

A38-B7-C57;

A38-B7-C58;

A38-B7-C59;

A38-B7-C60;

A38-B7-C61;

A38-B7-C62;

A38-B7-C63;

A38-B7-C64;

A38-B7-C65;

A38-B7-C66;

A38-B7-C67;

A38-B7-C68;

A1-B8-C1;

Al-B8-C2;

A1-B8-C3;

A1-B8-C4;

A1-B8-C5;

A1-B8-C6;

A1-B8-C7;

A1-B8-C8;

A1-B8-C9;

A1-B8-C10;

A1-B8-C11;

A1-B8-C12;

A1-B8-C13;

A1-B8-C14;

A1-B8-C15;

A1-B8-C16;

A1-B8-C17;

A1-B8-C18;

A1-B8-C19;

A1-B8-C20;

A1-B8-C21;

A1-B8-C22;

A1-B8-C23;

A1-B8-C24;

A1-B8-C25;

A1-B8-C26;

A1-B8-C27;

A1-B8-C28;

A1-B8-C29;

A1-B8-C30;

A1-B8-C31;

A1-B8-C32;

A1-B8-C33;

A1-B8-C34;

A1-B8-C35;

A1-B8-C36;

A1-B8-C37;

A1-B8-C38;

A1-B8-C39;

A1-B8-C40;

A1-B8-C41;

A1-B8-C42;

A1-B8-C43;

A1-B8-C44;

A1-B8-C45;

A1-B8-C46;

A1-B8-C47;

A1-B8-C48;

Al-B8-C49;

A1-B8-C50;

A1-B8-C51;

A1-B8-C52;

A1-B8-C53;

A1-B8-C54;

A1-B8-C55;

A1-B8-C56;

A1-B8-C57;

A1-B8-C58;

A1-B8-C59;

A1-B8-C60;

A1-B8-C61;

A1-B8-C62;

-201 • I

A1-B8-C63;

A1-B8-C64;

A1-B8-C65;

A1-B8-C66;

A1-B8-C67;

A1-B8-C68;

A2-B8-C1;

A2-B8-C2;

A2-B8-C3;

A2-B8-C4;

A2-B8-C5;

A2-B8-C6;

A2-B8-C7;

A2-B8-C8;

A2-B8-C9;

A2-B8-C10;

A2-B8-C11;

A2-B8-C12;

A2-B8-C13;

A2-B8-C14;

A2-B8-C15;

A2-B8-C16;

A2-B8-C17;

A2-B8-C18;

A2-B8-C19;

A2-B8-C20;

A2-B8-C21;

A2-B8-C22;

A2-B8-C23;

A2-B8-C24;

A2-B8-C25;

A2-B8-C26;

A2-B8-C27;

A2-B8-C28;

A2-B8-C29;

A2-B8-C30;

A2-B8-C31;

A2-B8-C32;

A2-B8-C33;

A2-B8-C34;

A2-B8-C35;

A2-B8-C36;

A2-B8-C37;

A2-B8-C38;

A2-B8-C39;

A2-B8-C40;

A2-B8-C41;

A2-B8-C42;

A2-B8-C43;

A2-B8-C44;

A2-B8-C45;

A2-B8-C46;

A2-B8-C47;

A2-B8-C48;

A2-B8-C49;

A2-B8-C50;

A2-B8-C51;

A2-B8-C52;

A2-B8-C53;

A2-B8-C54;

A2-B8-C55;

A2-B8-C56;

A2-B8-C57;

A2-B8-C58;

A2-B8-CS9;

A2-B8-C60;

A2-B8-C61;

A2-B8-C62;

A2-B8-C63;

A2-B8-C64;

A2-B8-C65;

A2-B8-C66;

A2-B8-C67;

A2-B8-C68;

A3-B8-C1;

A3-B8-C2;

A3-B8-C3;

A3-B8-C4;

A3-B8-C5;

A3-B8-C6;

A3-B8-C7;

A3-B8-C8;

A3-B8-C9;

A3-B8-C10;

A3-B8-C11;

A3-B8-C12;

A3-B8-C13;

A3-B8-C14;

A3-B8-C15;

A3-B8-C16;

A3-B8-C17;

A3-B8-C18;

A3-B8-C19;

A3-B8-C20;

A3-B8-C21;

A3-B8-C22;

A3-B8-C23;

A3-B8-C24;

A3-B8-C25;

A3-B8-C26;

A3-B8-C27;

A3-B8-C28;

A3-B8-C29;

A3-B8-C30;

A3-B8-C31;

A3-B8-C32;

A3-B8-C33;

A3-B8-C34;

A3-B8-C35;

A3-B8-C36;

A3-B8-C37;

A3-B8-C38;

A3-B8-C39;

A3-B8-C40;

A3-B8-C41;

A3-B8-C42;

A3-B8-C43;

A3-B8-C44;

A3-B8-C45;

A3 - BS - C46;

A3-B8-C47;

A3-B8-C48;

A3-B8-C49;

A3-B8-C50;

A3-B8-C51;

A3-B8-C52;

A3-B8-C53;

A3-B8-C54;

A3-B8-C55;

A3-B8-C55;

A3-B8-C57;

A3-B8-C58;

A3-B8-C59;

A3-B8-C60;

A3-B8-C61;

A3-B8-C62;

A3-B8-C63;

A3-B8-C64;

A3-B8-C65;

A3-B8-C66;

A3-B8-C67;

A3-B8-C68;

A4-B8-C1;

A4-B8-C2;

A4-B8-C3;

A4-B8-C4;

A4-B8-C4;

A4-B8-C6;

A4-B8-C7;

A4-B8-C8;

A4-B8-C9;

A4-B8-C10;

A4-B8-C11;

A4-B8-C12;

A4-B8-C13;

A4-B8-C14;

A4 - B8 - C15;

A4 - B8 - C16;

A4-B8-C17;

A4-B8-C18;

A4-B8-C19;

A4-B8-C20;

A4-B8-C21;

A4-B8-C22;

A4-B8-C23;

-202- f · · • · · · • · · • φ φ • φ · φφφ φ φ ·· « φ φ · φ φ φφφ · * J • φ φ · C Φ ΦΦΦ A4-B8-C24; A4-B8-C57; A5-B8-C22; A5-B8-C55; A6-B8-C20; A4-B8-C25; A4-B8-C58; A5-B8-C23; A5-B8-C56; A6-B8-C21; A4-B8-C26; A4-B8-C59; A5-B8-C24; A5-B8-C57; A6-B8-C22; A4-B8-C27; A4-B8-C60; A5-B8-C25; A5-B8-C58; A6-B8-C23; A4-B8-C28; A4-B8-C61; A5-B8-C26; A5-B8-C59; A6-B8-C24; A4-B8-C29; A4-B8-C62; A5-B8-C27; A5-B8-C60; A6-B8-C25; A4-B8-C30; A4-B8-C63; A5-B8-C28; A5-B8-C61; A6-B8-C26; A4-B8-C31; A4-B8-C64; A5-B8-C29; A5-B8-C62; A6-B8-C27; A4-B8-C32; A4-B8-C65; A5-B8-C30; A5-B8-C63; A6-B8-C28; A4-B8-C33; A4-B8-C66; A5-B8-C31; A5-B8-C64; A6-B8-C29; A4-B8-C34; A4-B8-C67; A5-B8-C32; A5-B8-C65; A6-B8-C30; A4-B8-C35; A4-B8-C68; A5-B8-C33; A5-B8-C66; A6-B8-C31; A4-B8-C36; A5-B8-C1; A5-B8-C34; A5-B8-C67; A6-B8-C32; A4-B8-C37; A5-B8-C2; A5-B8-C35; A5-B8-C68; A6-B8-C33; A4-B8-C38; A5-B8-C3; A5-B8-C36; A6-B8-C1; A6-B8-C34; A4-B8-C39; A5-B8-C4; A5-B8-C37; A6-B8-C2; A6-B8-C35; A4-B8-C40; A5-B8-C5; A5-B8-C38; A6-B8-C3; A6-B8-C36; A4-B8-C41; A5-B8-C6; A5-B8-C39; A6-B8-C4; A6-B8-C37; A4-B8-C42; A5-B8-C7; A5-B8-C40; A6-B8-C5; A6-B8-C38; A4-B8-C43; A5-B8-C8; AS-B8-C41; A6-B8-C6; A6-B8-C39; A4-B8-C44; A5-B8-C9; A5-B8-C42; A6-B8-C7; A6-B8-C40; A4-B8-C45; A5-B8-C10; A5-B8-C43; A6-B8-C8; A6-B8-C41; A4 - BS - C46; A5-B8-C11; A5-B8-C44; A6-B8-C9; A6-B8-C42; A4-B8-C47; A5-B8-C12; A5-B8-C45; A6-B8-C10; A6-B8-C43; A4-B8-C48; A5-B8-C13; A5-B8-C46; A6-B8-C11; A6-B8-C44; A4-B8-C50; A5-B8-C14; A5-B8-C47; A6-B8-C12; A6-B8-C45; A4-B8-C50; A5-B8-C15; A5-B8-C48; A6-B8-C13; A6-B8-C46; A4-B8-C51; A5-B8-C16; A5-B8-C49; A6-B8-C14; A6-B8-C47; A4-B8-C52; A5-B8-C17; A5-B8-C50; A6-B8-C15; A6-B8-C48; A4-B8-C53; A5-B8-C18; A5-B8-C51; A6-B8-C16; A6-B8-C49; A4-B8-C54; A5-B8-C19; A5-B8-C52; A6-B8-C17; A6-B8-C50; A4-B8-C55; A5-B8-C20; A5-B8-C53; A6-B8-C18; A6-B8-C51; A4-B8-C55; A5-B8-C21; A5-B8-C54; A6-B8-C19; A6-B8-CS1;

• · ·

-203 • ···

A6-B8-C53;

A6-B8-C54;

A6-B8-C55;

A6-B8-C55;

A6-B8-C57;

A6-B8-C58;

A6-B8-C59;

A6-B8-C60;

A6-B8-C61;

A6-B8-C62;

A6-B8-C63;

A6-B8-C64;

A6-B8-C65;

A6-B8-C66;

A6-B8-C67;

A6-B8-C68;

A7-B8-C1;

A7-B8-C2;

A7-B8-C3;

A7-B8-C4;

A7-B8-C5;

A7-B8-C6;

A7-B8-C7;

A7-B8-C8;

A7-B8-C9;

A7-B8-C10;

A7-B8-C11;

(

A7-B8-C12;

A7-B8-C13;

A7-B8-C14;

A7-B8-C15;

A7-B8-C16;

A7-B8-C17;

A7-B8-C18;

A7-B8-C19;

A7-B8-C20;

A7-B8-C21;

A7-B8-C22;

A7-B8-C23;

A7-B8-C24;

A7-B8-C25;

A7-B8-C26;

A7-B8-C27;

A7-B8-C28;

A7-B8-C29;

A7-B8-C30;

A7-B8-C31;

A7-B8-C32;

A7-B8-C33;

A7-B8-C34;

77-B8-C35;

A7-B8-C36;

77-B8-C37;

A7-B8-C38;

A7-B8-C39;

77-B8-C40;

77-B8-C41;

A7-B8-C42;

A7-B8-C43;

A7-B8-C44;

A7-B8-C45;

A7-B8-C46;

A7-B8-C47;

77-B8-C48;

77-B8-C49;

A7-B8-C50;

A7-B8-C51;

77-B8-C52;

A7-B8-C53;

A7-B8-C54;

A7-B8-C55;

A7-B8-C56;

A7-B8-C57;

A7-B8-C58;

A7-B8-C59;

A7-B8-C60;

A7-B8-C61;

A7-B8-C62;

A7-B8-C63;

A7-B8-C64;

A7-B8-C65;

A7-B8-C66;

A7-B8-C67;

A7-B8-C68;

A8-B8-C1;

A8-B8-C2;

A8-B8-C3;

A8-B8-C4;

A8-B8-C5;

A8-B8-C6;

A8-B8-C7;

A8-B8-C8;

A8-B8-C95

A8-B8-C10;

A8-B8-C11;

A8-B8-C12;

A8-B8-C13;

A8-B8-C14;

A8-B8-C15;

A8-B8-C16;

A8-B8-C17;

A8-B8-C18;

A8-B8-C19;

A8-B8-C20;

A8-B8-C21;

A8-B8-C22;

A8-B8-C23;

A8-B8-C24;

A8-B8-C25;

A8-B8-C26;

A8-B8-C27;

A8-B8-C28;

A8-B8-C29;

A8-B8-C30;

A8-B8-C31;

A8-B8-C32;

A8-B8-C33;

A8-B8-C34;

A8-B8-C35;

A8-B8-C36;

A8-B8-C37;

A8-B8-C38;

A8-B8-C39;

A8-B8-C40;

A8-B8-C41;

A8-B8-C42;

A8-B8-C43;

A8-B8-C44;

A8-B8-C45;

A8-B8-C46;

A8-B8-C47;

A8-B8-C48;

A8-B8-C49;

A8-B8-C50;

A8-B8-C51;

A8-B8-C52;

A8-B8-C53;

A8-B8-C54;

A8-B8-C55;

A8-B8-C56;

A8-B8-C57;

A8-B8-C58;

A8-B8-C59;

A8-B8-C60;

A8-B8-C61;

A8-B8-C62;

A8-B8-C63;

A8-B8-C64;

A8-B8-C65;

A8-B8-C66;

A8-B8-C67;

A8-B8-C68;

A9-B8-C1;

A9-B8-C2;

A9-B8-C3;

A9-B8-C4;

A9-B8-C5;

A9-B8-C6;

A9-B8-C7;

A9-B8-C8;

A9-B8-C9;

A9-B8-C10;

A9-B8-C11;

A9-B8-Cl2;

A9-B8-C13;

-204-

• * · • · • · ♦ • »· • • • » • 4 • ·· 4 * • 4 4 β 4 4 4 i · · 0 • 4 · • · · 4 • · · 44

* • ·

A9-B8-C14;

A9-B8-C15;

A9-B8-C16;

A9-B8-C17;

A9-B8-C18;

A9-B8-C19;

A9-B8-C20;

A9-B8-C21;

A9-B8-C22;

A9-B8-C23;

99-B8-C24;

99-B8-C25;

A9-B8-C26;

A9-B8-C27;

A9-B8-C28;

A9-B8-C29;

99-B8-C30;

99-B8-C31;

99-B8-C32;

99-B8-C33;

A9-B8-C34;

99-B8-C35;

99-B8-C36;

99-B8-C37;

99-B8-C38;

99-B8-C39;

99-B8-C40;

99-B8-C41;

99-B8-C42;

A9-B8-C43;

A9-B8-C44;

99-B8-C45;

99-B8-C46;

99-B8-C47;

99-B8-C48;

99-B8-C49;

99-B8-C50;

99-B8-C51;

99-B8-C52;

A9-B8-C53;

99-B8-C54;

99-B8-C55;

99-B8-C56;

99-B8-C57;

99-B8-C58;

99-B8-C59;

99-B8-C60;

99-B8-C61;

99-B8-C62;

99-B8-C63;

99-B8-C64;

99-B8-C65;

A9-B8-C66;

A9-B8-C67;

A9-B8-C68;

A10-B8-C1;

A10-B8-C2;

A10-B8-C3;

A10-B8-C4;

A10-B8-C5;

A10-B8-C6;

A10-B8-C7;

A10-B8-C8;

A10-B8-C9;

A10-B8-C10;

A10-B8-C11;

A10-B8-C12;

A10-B8-C13;

A10-B8-C14;

A10-B8-C15;

A10-B8-C16;

A10-B8-C17;

A10-B8-C18;

A10-B8-C19;

A10-B8-C20;

A10-B8-C21;

A10-B8-C22;

A10-B8-C23;

A10-B8-C24;

A10-B8-C25;

A10-B8-C26;

A10-B8-C27;

A10-B8-C28;

A10-B8-C29;

A10-B8-C30;

A10-B8-C31;

A10-B8-C32;

A10-B8-C33;

A10-B8-C34;

A10-B8-C35;

A10-B8-C36;

A10-B8-C37;

A10-B8-C38;

A10-B8-C39;

A10-B8-C40;

A10-B8-C41;

A10-B8-C42;

A10-B8-C43;

A10-B8-C44;

A10-B8-C45;

A10-B8-C46;

A10-B8-C47;

A10-B8-C48;

A10-B8-C49;

A10-B8-C50;

A10-B8-C51;

A10-B8-C52;

A10-B8-C53;

A10-B8-C54;

A10-B8-C55;

A10-B8-C56;

A10-B8-C57;

A10-B8-C58;

A10-B8-C59;

A10-B8-C60;

A10-B8-C61;

A10-B8-C62;

A10-B8-C63;

A10-B8-C64;

A10-B8-C65;

A10-B8-C66;

A10-B8-C67;

A10-B8-C68;

AX1-B8-C1;

A11-B8-C2;

A11-B8-C3;

A11-B8-C4;

A11-B8-C5;

A11-B8-C6;

A11-B8-C7;

A11-B8-C8;

A11-B8-C9;

A11-B8-C10;

A11-B8-C11;

A11-B8-C12;

A11-B8-C13;

A11-B8-C14;

A11-B8-C15;

A11-B8-C16;

A11-B8-C17;

A11-B8-C18;

A11-B8-C19;

A11-B8-C20;

A11-B8-C21;

A11-B8-C22;

A11-B8-C23;

A11-B8-C24;

A11-B8-C25;

A11-B8-C26;

A11-B8-C27;

A11-B8-C28;

A11-B8-C29;

A11-B8-C30;

A11-B8-C31;

A11-B8-C32;

A11-B8-C33;

A11-B8-C34;

A11-B8-C35;

A11-B8-C36;

A11-B8-C37;

A11-B8-C38;

A11-B8-C39;

A11-B8-C40;

A11-B8-C41;

AU-B8-C42;

• · ·

-205I »· · · φ · · · φ · · · φ · φ · · · · · φ · φ · φ · φ · · · ·

A11-B8-C43;

A11-B8-C44;

A11-B8-C45;

A11-B8-C46;

A11-B8-C47;

A11-B8-C48;

A11-B8-C49;

A11-B8-C50;

A11-B8-C51;

A11-B8-C52;

A11-B8-C53;

A11-B8-C54;

A11-B8-C55;

A11-B8-C56;

A11-B8-C57;

A11-B8-C58;

A11-B8-C59;

A11-B8-C60;

A11-B8-C61;

A11-B8-C62;

A11-B8-C63;

A11-B8-C64;

A11-B8-C65;

A1I-B8-C66;

A11-B8-C67;

A11-B8-C68;

Al2-B8-C1;

(

A12-B8-C2;

A12-B8-C3;

A12-B8-C4;

A12-B8-C5;

A12-B8-C6;

A12-B8-C7;

A12-B8-C8;

A12-B8-C9;

A12-B8-C10;

A12-B8-C11;

A12-B8-C12;

A12-B8-C13;

A12-B8-C14;

A12-B8-C15;

A12-B8-C16;

A12-B8-C17;

A12-B8-C18;

A12-B8-C19;

A12-B8-C20;

A12-B8-C21;

A12-B8-C22;

A12-B8-C23;

A12-B8-C24;

A12-B8-C25;

A12-B8-C26;

A12-B8-C27;

A12-B8-C28;

A12-B8-C29;

A12-B8-C30;

A12-B8-C31;

A12-B8-C32;

A12-B8-C33;

A12-B8-C34;

A12-B8-C35;

A12-B8-C36;

A12-B8-C37;

A12-B8-C38;

Al2-B8-C39;

A12-B8-C40;

A12-B8-C41;

A12-B8-C42;

Al2-B8-C43;

A12-B8-C44;

A12-B8-C45;

A12-B8-C46;

A12-B8-C47;

A12-B8-C48;

A12-B8-C49;

A12-B8-C50;

A12-B8-C51;

A12-B8-C52;

A12-B8-C53;

A12-B8-C54;

A12-B8-C55;

A12-B8-C56;

A12-B8-C57;

A12-B8-C58;

A12-B8-C59;

A12-B8-C60;

A12-B8-C61;

A12-B8-C62;

A12-B8-C63;

A12-B8-C64;

A12-B8-C65;

A12-B8-C66;

A12-B8-C67;

A12-B8-C68;

A13-B8-C1;

A13-B8-C2;

A13-B8-C3;

A13-B8-C4;

A13-B8-C5;

A13-B8-C6;

A13‘B8-C7;

A13-B8-C8;

Al3-B8-C9;

A13-B8-C10;

A13-B8-C11;

A13-B8-C12;

A13-B8-C13;

A13-B8-C14;

A13-B8-C15;

A13-B8-C16;

A13-B8-C17;

A13-B8-C18;

A13-B8-C19;

A13-B8-C20;

A13-B8-C21;

A13-B8-C22;

A13-B8-C23;

A13-B8-C24;

A13-B8-C25;

A13-B8-C26;

A13-B8-C27;

A13-B8-C28;

A13-B8-C29;

A13-B8-C30;

A13-B8-C31;

A13-B8-C32;

A13-B8-C33;

A13-B8-C34;

A13-B8-C35;

A13-B8-C36;

A13-B8-C37;

A13-B8-C38;

A13-B8-C39;

A13-B8-C40;

A13-B8-C41;

A13-B8-C42;

A13-B8-C43;

A13-B8-C44;

A13-B8-C45;

A13-B8-C46;

A13-B8-C47;

A13-B8-C48;

A13-B8-C49;

A13-B8-C50;

A13-B8-C51;

A13-B8-C52;

A13-B8-C53;

A13-B8-C54;

A13-B8-C55;

A13-B8-C56;

A13-B8-C57;

A13-B8-C58;

A13-B8-C59;

Al3-B8-C60;

A13-B8-C61;

A13-B8-C62;

A13-B8-C63;

A13-B8-C64;

A13-B8-C65;

A13-B8-C66;

A13-B8-C67;

A13-B8-C68;

A14-B8-C1;

A14-B8-C2;

A14-B8-C3;

-206-

A14-B8-C4; A14-B8-C37; A15-B8-C2; A15-B8-C35; A15-B8-C68; A14-B8-C5; A14-B8-C38; A15-B8-C3; A15-B8-C36; A16-B8-C1; A14-B8-C6; A14-B8-C39; A15-B8-C4; A15-B8-C37; A16-B8-C2; A14-B8-C7; A14-B8-C40; A15-B8-C5; A15-B8-C38; A16-B8-C3; A14-B8-C8; A14-B8-C41; A15-B8-C6; A15-B8-C39; A16-B8-C4; A14-B8-C9; A14-B8-C42; A15-B8-C7; A15-B8-C40; A16-B8-C5; A14-B8-C10; A14-B8-C43; A15-B8-C8; A15-B8-C41; A16-B8-C6; A14-B8-C11; A14-B8-C44; A15-B8-C9; A15-B8-C42; A16-B8-C7; A14-B8-C12; A14-B8-C45; A15-B8-C10; A15-B8-C43; A16-B8-C8; A14-B8-C13; A14-B8-C46; A15-B8-C11; A15-B8-C44; A16-B8-C9; A14-B8-C14; A14-B8-C47; A15-B8-C12; A15-B8-C45; A16-B8-C10; A14-B8-C15; A14-B8-C48; A15-B8-C13; A15-B8-C46; A16-B8-C11; A14-B8-C16; A14-B8-C49; A15-B8-C14; A15-B8-C47; A16-B8-C12; A14-B8-C17; A14-B8-C50; A15-B8-C15; A15-B8-C48; A16-B8-C13; A14-B8-C18; A14-B8-C51; A15-B8-C16; A15-B8-C49; A16-B8-C14; A14-B8-C19; A14-B8-C52; A15-B8-C17; A15-B8-C50; A16-B8-C15; A14-B8-C20; A14-B8-C53; A15-B8-C18; A15-B8-C51; A16-B8-C16; A14-B8-C21; A14-B8-C54; A15-B8-C19; A15-B8-C52; A16-B8-C17; A14-B8-C22; A14-B8-C55; A15-B8-C20; A15-B8-C53; A16-B8-C17: A14-B8-C23; A14-B8-C56; A15-B8-C21; A15-B8-C54; A16-B8-C19; A14-B8-C24; A14-B8-C57; A15-B8-C22; A15-B8-C55; A16-B8-C20; A14-B8-C25; A14-B8-C58; A15-B8-C23; A15-B8-C56; A16-B8-C21; A14-B8-C26; A14-B8-C59; A15-B8-C24; A15-B8-C57; A16-B8-C22; A14-B8-C27; A14-B8-C60; A15-B8-C25; A15-B8-C58; A16-B8-C23; A14-B8-C28; A14-B8-C61; A15-B8-C26; A15-B8-C59; A16-B8-C24; A14-B8-C29; A14-B8-C62; A15-B8-C27; A15-B8-C60; A16-B8-C25; A14-B8-C30; < A14-B8-C63; A15-B8-C28; A15-B8-C61; A16-B8-C26; A14-B8-C31; A14-B8-C64; A15-B8-C29; A15-B8-C62; A16-B8-C27; A14-B8-C32; A14-B8-C65; A15-B8-C30; A15-B8-C63; A16-B8-C28; A14-B8-C33; A14-B8-C66; A15-B8-C31; A15-B8-C64; A16-B8-C29; A14-B8-C34; A14-B8-C67; A15-B8-C32; A15-B8-C65; A16-B8-C30; A14-B8-C35; A14-B8-C68; A15-B8-C33; A15-B8-C66; A16-B8-C31; A14-B8-C36; A15-B8-C1; A15-B8-C34; A15-B8-C67; A16-B8-C32;

Φ φ φ φ

-207A16-B8-C33;

A16-B8-C34;

A16-B8-C35;

A16-B8-C36;

A16-B8-C37;

A16-B8-C38;

A16-B8-C39;

A16-B8-C40;

A16-B8-C41;

A16-B8-C42;

A16-B8-C43;

A16-B8-C44;

A16-B8-C45;

A16-B8-C46;

A16-B8-C47;

A16-B8-C48;

A16-B8-C49;

A16-B8-C50;

A16-B8-C51;

A16-B8-C52;

A16-B8-C53;

A16-B8-C54;

A16-B8-C55;

A16-B8-C56;

A16-B8-C57;

A16-B8-C58;

A16-B8-C59;

A16-B8-C60;

A16-B8-C61;

A16-B8-C62;

A16-B8-C63;

A16-B8-C64;

A16-B8-C65;

A16-B8-C66;

A16-B8-C67;

A16-B8-C68;

A17-B8-C1;

A17-B8-C2;

A17-B8-C3;

A17-B8-C4;

A17-B8-C5;

A17-B8-C6;

A17-B8-C7;

A17-B8-C8;

A17-B8-C9;

A17-B8-C10;

A17-B8-C11;

A17-B8-C12;

A17-B8-C13;

A17-B8-C14;

A17-B8-C15;

A17-B8-C16;

A17-B8-C17;

A17-B8-C18;

A17-B8-C19;

A17-B8-C20;

A17-B8-C21;

A17-B8-C22;

A17-B8-C23;

A17-B8-C24;

A17-B8-C25;

A17-B8-C26;

A17-B8-C27;

A17-B8-C28;

A17-B8-C29;

A17-B8-C30;

A17-B8-C31;

A17-B8-C32;

A17-B8-C33;

A17-B8-C34;

A17-B8-C35;

A17-B8-C36;

A17-B8-C37;

A17-B8-C38;

A17-B8-C39;

A17-B8-C40;

A17-B8-C41;

A17-B8-C42;

A17-B8-C43;

A17-B8-C44;

A17-B8-C45;

A17-B8-C46;

A17-B8-C47;

A17-B8-C48;

A17-B8-C49;

A17-B8-C50;

A17-B8-C51;

A17-B8-C52;

A17-B8-C53;

A17-B8-C54;

A17-B8-C55;

A17-B8-C56;

A17-B8-C57;

A17-B8-C58;

A17-B8-C59;

A17-B8-C60;

A17-B8-C61;

A17-B8-C62;

A17-B8-C63;

A17-B8-C64;

A17-B8-C65;

A17-B8-C66;

A17-B8-C67;

A17-B8-C68;

A18-B8-C1;

A18-B8-C2;

A18-B8-C3;

A18-B8-C4;

A18-B8-C5;

A18-B8-C6;

A18-B8-C7;

A18-B8-C8;

A18-B8-C9;

A18-B8-C10;

A18-B8-C11;

A18-B8-C12;

A18-B8-C13;

A18-B8-C14;

A18-B8-C15;

A18-B8-C16;

A18-B8-C17;

A18-B8-C18;

A18-B8-C19;

A18-B8-C20;

A18-B8-C21;

A18-B8-C22;

A18-B8-C23;

A18-B8-C24;

A18-B8-C25;

A18-B8-C26;

A18-B8-C27;

A18-B8-C28;

A18-B8-C29;

A18-B8-C30;

A18-B8-C31;

A18-B8-C32;

A18-B8-C33;

A18-B8-C34;

A18-B8-C35;

A18-B8-C36;

A18-B8-C37;

A18-B8-C38;

A18-B8-C39;

A18-B8-C40;

A18-B8-C41;

A18-B8-C42;

A18-B8-C43;

A18-B8-C44;

A18-B8-C45;

A18-B8-C46;

A18-B8-C47;

A18-B8-C48;

A18-B8-C49;

A18-B8-C50;

A18-B8-C51;

A18-B8-C52;

A18-B8-C53;

A18-B8-C54;

A18-B8-C55;

A18-B8-C56;

A18-B8-C57;

A18-B8-C58;

A18-B8-C59;

A18-B8-C60;

A18-B8-C61;

• · · · · · · · · ·

-208A18-B8-C62;

A18-B8-C63;

A18-B8-C64;

A18-B8-C65;

A18-B8-C66;

A18-B8-C67;

A18-B8-C68;

A19-B8-C1;

A19-B8-C2;

A19-B8-C3;

A19-B8-C4;

A19-B8-C5;

A19-B8-C6;

A19-B8-C7;

A19-B8-C8;

A19-B8-C9;

A19-B8-C10;

A19-B8-C11;

A19-B8-C12;

A19-B8-C13;

A19-B8-C14;

A19-B8-C15;

A19-B8-C16;

A19-B8-C17;

A19-B8-C18;

A19-B8-C19;

A19-B8-C20;

A19-B8-C21;

A19-B8-C22;

A19-B8-C23;

A19-B8-C24;

A19-B8-C25;

A19-B8-C26;

A19-B8-C27;

A19-B8-C28;

A19-B8-C29;

A19-B8-C30;

A19-B8-C31;

A19-B8-C32;

A19-B8-C33;

A19-B8-C34;

A19-B8-C35;

A19-B8-C36;

A19-B8-C37;

A19-B8-C38;

A19-B8-C39;

A19-B8-C40;

A19-B8-C41;

A19-B8-C42;

A19-B8-C43;

A19-B8-C44;

A19-B8-C45;

A19-B8-C46;

A19-B8-C47;

A19-B8-C48;

A19-B8-C49;

A19-B8-C50;

A19-B8-C51;

A19-B8-C52;

A19-B8-C53;

A19-B8-C54;

A19-B8-C55;

A19-B8-C56;

A19-B8-C57;

A19-B8-C58;

A19-B8-C59;

A19-B8-C60;

A19-B8-C61;

A19-B8-C62;

A19-B8-C63;

A19-B8-C64;

A19-B8-C65;

A19-B8-C66;

A19-B8-C67;

A19-B8-C68;

A20-B8-C1;

A20-B8-C2;

A20-B8-C3;

A20-B8-C4;

A20-B8-C5;

A20-B8-C6;

A20-B8-C7;

A20-B8-C8;

A20-B8-C9;

A20-B8-C10;

A20-B8-C11;

A20-B8-C12;

A20-B8-C13;

A20-B8-C14;

A20-B8-C15;

A20-B8-C16;

A20-B8-C17;

A20-B8-C18;

A20-B8-C19;

A20-B8-C20;

A20-B8-C21;

A20-B8-C22;

A20-B8-C23;

A20-B8-C24;

A20-B8-C25;

A20-B8-C26;

A20-B8-C27;

A20-B8-C28;

A20-B8-C29;

A20-B8-C30;

A20-B8-C31;

A20-B8-C32;

A20-B8-C33;

A20-B8-C34;

A20-B8-C35;

A20-B8-C36;

A20-B8-C37;

A20-B8-C38;

A20-B8-C39;

A20-B8-C40;

A20-B8-C41;

A20-B8-C42;

A20-B8-C43;

A20-B8-C44;

A20-B8-C45;

A20-B8-C46;

A20-B8-C47;

A20-B8-C48;

A20-B8-C49;

A20-B8-C50;

A20-B8-C51;

A20-B8-C52;

A20-B8-C53;

A20-B8-C54;

A20-B8-C55;

A20-B8-C56;

A20-B8-C57;

A20-B8-C58

A20-B8-CS9

A20-B8-C60;

A20-B8-C61;

A20-B8-C62;

A20-B8-C63;

A20-B8-C64;

A20-B8-C65;

A20-B8-C66;

A20-B8-C67;

A20-B8-C68;

A21-B8-C1;

A21-B8-C2;

A21-B8-C3;

A21-B8-C4;

A21-B8-C5;

A21-B8-C6;

A21-B8-C7;

A21-B8-C8;

A21-B8-C9;

A21-B8-C10;

A21-B8-C11;

A21-B8-C12;

A21-B8-C13;

A21-B8-C14;

A21-B8-C15;

A21-B8-C16;

A21-B8-C17;

A21-B8-C18;

A21-B8-C19;

A21-B8-C20;

A21-B8-C21;

A21-B8-C22;

-209A21-B8-C23;

A21-B8-C24;

A21-B8-C25;

A21-B8-C26;

A21-B8-C27;

A21-B8-C28;

A21-B8-C29;

A21-B8-C30;

A21-B8-C31;

A21-B8-C32;

A21-B8-C33;

A21-B8-C34;

A21-B8-C35;

A21-B8-C36;

A21-B8-C37;

A21-B8-C38;

A21-B8-C39;

A21-B8-C40;

A21-B8-C41;

A21-B8-C42;

A21-B8-C43;

A21-B8-C44;

A21-B8-C45;

A21-B8-C46;

A21-B8-C47;

A21-B8-C48;

A21-B8-C49;

A21-B8-C50;

A21-B8-C51;

A21-B8-C52;

A21-B8-C53;

A21-B8-C54;

A21-B8-C55;

A21-B8-C56;

A21-B8-C57;

A21-B8-C58;

A21-B8-C59;

A21-B8-C60;

A21-B8-C61;

A21-B8-C62;

A21-B8-C63;

A21-B8-C64;

A21-B8-C65;

A21-B8-C66;

A21-B8-C67;

A21-B8-C68;

A22-B8-C1;

A22-B8-C2;

A22-B8-C3;

A22-B8-C4;

A22-B8-C5;

A22-B8-C6;

A22-B8-C7;

A22-B8-C8;

A22-B8-C9;

A22-B8-C10;

A22-B8-C11;

A22-B8-C12;

A22-B8-C13;

A22-B8-C14;

A22-B8-C15;

A22-B8-C16;

A22-B8-C17;

A22-B8-C18;

A22-B8-C19;

A22-B8-C20;

A22-B8-C21;

A22-B8-C22;

A22-B8-C23;

A22-B8-C24;

A22-B8-C25;

A22-B8-C26;

A22-B8-C27;

A22-B8-C28;

A22-B8-C29;

A22-B8-C30;

A22-B8-C31;

A22-B8-C32;

A22-B8-C33;

A22-B8-C34;

A22-B8-C35;

A22-B8-C36;

A22-B8-C37;

A22-B8-C38;

A22-B8-C39;

A22-B8-C40;

A22-B8-C41;

A22-B8-C42;

A22-B8-C43;

A22-B8-C44;

A22-B8-C45;

A22-B8-C46;

A22-B8-C47;

A22-B8-C48;

A22-B8-C49;

A22-B8-C50;

A22-B8-C51;

A22-B8-C52;

A22-B8-C53;

A22-B8-C54;

A22-B8-C55;

A22-B8-C56;

A22-B8-C57;

A22-B8-C58;

A22-B8-C59;

A22-B8-C60;

A22-B8-C61;

A22-B8-C62;

A22-B8-C63;

A22-B8-C64;

A22-B8-C65;

A22-B8-C66;

A22-B8-C67;

A22-B8-C68;

A23-B8-C1;

A23-B8-C2;

A23-B8-C3;

A23-B8-C4;

A23-B8-C5;

A23-B8-C6;

A23-B8-C7;

A23-B8-C8;

A23-B8-C9;

A23-B8-C10;

A23-B8-C11;

A23-B8-C12;

A23-B8-C13;

A23-B8-C14;

A23-B8-C15;

A23-B8-C16;

A23-B8-C17;

A23-B8-C18;

A23-B8-C19;

A23-B8-C20;

A23-B8-C21;

A23-B8-C22;

A23-B8-C23;

A23-B8-C24;

A23-B8-C25;

A23-B8-C26;

A23-B8-C27;

A23-B8-C28;

A23-B8-C29;

A23-B8-C30;

A23-B8-C31;

A23-B8-C32;

A23-B8-C33;

A23-B8-C34;

A23-B8-C35;

A23-B8-C36;

A23-B8-C37;

A23-B8-C38;

A23-B8-C39;

A23-B8-C40;

A23-B8-C41;

A23-B8-C42;

A23-B8-C43;

A23-B8-C44;

A23-B8-C45;

A23-B8-C46;

A23-B8-C47;

A23-B8-C48;

A23-B8-C49;

A23-B8-C50;

A23-B8-C51;

Tff tff tff tff tff

-210 tftf tftf tftf tftf tftf tftf

A23-B8-C52; A24-B8-C17; A24-B8-C50; A25-B8-C15; A25-B8-C48; A23-B8-C53; A24-B8-C18; A24-B8-C51; A25-B8-C16; A25-B8-C49; A23-B8-C54; A24-B8-C19; A24-B8-C52; A25-B8-C17; A25-B8-C50; A23-B8-C55; A24-B8-C20; A24-B8-C53; A25-B8-C18; A25-B8-C51; A23-B8-C56; A24-B8-C21; A24-B8-C54; A25-B8-C19; A25-B8-C52; A23-B8-C57; A24-B8-C22; A24-B8-C55; A25-B8-C20; A25-B8-C53; A23-B8-C58; A24-B8-C23; A24-B8-C56; A25-B8-C21; A25-B8-C54; A23-B8-C59; A24-B8-C24; A24-B8-C57; A25-B8-C22; A25-B8-C55; A23-B8-C60; A24-B8-C25; A24-B8-C58; A25-B8-C23; A25-B8-C56; A23-B8-C61; A24-B8-C26; A24-B8-C59; A25-B8-C24; A25-B8-C57; A23-B8-C62; A24-B8-C27; A24-B8-C60; A25-B8-C25; A25-B8-C58; A23-B8-C63; A24-B8-C28; A24-B8-C61; A25-B8-C26; A25-B8-C59; A23-B8-C64; A24-B8-C29; A24-B8-C62; A25-B8-C27; A25-B8-C60; A23-B8-C65; A24-B8-C30; A24-B8-C63; A25-B8-C28; A25-B8-C61; A23-B8-C66; A24-B8-C31; A24-B8-C64; A25-B8-C29; A25-B8-C62; A23-B8-C67; A24-B8-C32; A24-B8-C65; A25-B8-C30; A25-B8-C63; A23-B8-C68; A24-B8-C33; A24-B8-C66; A25-B8-C31; A25-B8-C64; A24-B8-C1; A24-B8-C34; A24-B8-C67; A25-B8-C32; A25-B8-C65; A24-B8-C2; A24-B8-C35; A24-B8-C68; A25-B8-C33; A25-B8-C66; A24-B8-C3; A24-B8-C36; A25-B8-C1; A25-B8-C34; 2525-B8-C67; A24-B8-C4; A24-B8-C37; A25-B8-C2; A25-B8-C35; A25-B8-C68; A24-B8-C5; A24-B8-C38; A2S-B8-C3; A25-B8-C36; A26-B8-C1; A24-B8-C6; A24-B8-C39; A25-B8-C4; A25-B8-C37; A26-B8-C2; A24-B8-C7; A24-B8-C40; A25-B8-C5; A25-B8-C38; A26-B8-C3; A24-B8-C8; A24-B8-C41; A25-B8-C6; A25-B8-C39; A26-B8-C4; A24-B8-C9; A24-B8-C42; A25-B8-C7; A25-B8-C40; A26-B8-C5; A24-B8-Q10; A24-B8-C43; A25-B8-C8; A25-B8-C41; A26-B8-C6; A24-B8-C11; A24-B8-C44; A25-B8-C9; A25-B8-C42; A26-B8-C7; A24-B8-C12; A24-B8-C45; A25-B8-C10; A25-B8-C43; A26-B8-C8; A24-B8-C13; A24-B8-C46; A25-B8-C11; A25-B8-C44; A26-B8-C9; A24-B8-C14; A24-B8-C47; A25-B8-C12; A25-B8-C45; A26-B8-C10; A24-B8-C15; A24-B8-C48; A25-B8-C13; A25-B8-C46; A26-B8-C11; A24-B8-C16; A24-B8-C49; A25-B8-C14; A25-B8-C47; A26-B8-C12;

-211 • · · ··· 99 99 • 9 9 9 9 9 9 9 99 ♦ 99 9 9 9 9 9

A26-B8-C13; A26-B8-C46; A27-B8-C11; A27-B8-C44; A28-B8-C9; A26-B8-C14; A26-B8-C47; A27-B8-C12; A27-B8-C45; A28-B8-C10; A26-B8-C15; A26-B8-C48; A27-B8-C13; A27-B8-C46; A28-B8-C11; A26-B8-C16; A26-B8-C49; A27-B8-C14; A27-B8-C47; A28-B8-C12; A26-B8-C17; A26-B8-C50; A27-B8-C15; A27-B8-C48; A28-B8-C13; A26-B8-C18; A26-B8-C51; A27-B8-C16; A27-B8-C49; A28-B8-C14; A26-B8-C19; A26-B8-C52; A27-B8-C17; A27-B8-C50; A28-B8-C15; A26-B8-C20; A26-B8-C53; A27-B8-C18; A27-B8-C51; A28-B8-C16; A26-B8-C21; A26-B8-C54; A27-B8-C19; A27-B8-CS2; A28-B8-C17; A26-B8-C22; A26-B8-C55; A27-B8-C20; A27-B8-C53; A28-B8-C18; A26-B8-C23; A26-B8-C56; A27-B8-C21; A27-B8-C54; A28-B8-C19; A26-B8-C24; A26-B8-C57; A27-B8-C22; A27-B8-C55; A28-B8-C20; A26-B8-C25; A26-B8-C58; A27-B8-C23; A27-B8-C56; A28-B8-C21; A26-B8-C26; A26-B8-C59; A27-B8-C24; A27-B8-C57; A28-B8-C22; A26-B8-C27; A26-B8-C60; A27-B8-C25; A27-B8-C58; A28-B8-C23; A26-B8-C28; A26-B8-C61; A27-B8-C26; A27-B8-C59; A28-B8-C24; A26-B8-C29; A26-B8-C62; A27-B8-C27; A27-B8-C60; A28-B8-C25; A26-B8-C30; A26-B8-C63; A27-B8-C28; A27-B8-C61; A28-B8-C26; A26-B8-C31; A26-B8-C64; A27-B8-C29; A27-B8-C62; A28-B8-C27; A26-B8-C32; A26-B8-C65; A27-B8-C30; A27-B8-C63; A28-B8-C28; A26-B8-C33; A26-B8-C66; A27-B8-C31; A27-B8-C64; A28-B8-C29; A26-B8-C34; A26-B8-C67; A27-B8-C32; A27-B8-C65; A28-B8-C30; A26-B8-C35; A26-B8-C68; A27-B8-C33; A27-B8-C66; A28-B8-C31; A26-B8-C36; A27-B8-C1; A27-B8-C34; A27-B8-C67; A28-B8-C32; A26-B8-C37; A27-B8-C2; A27-B8-C35; A27-B8-C68; A28-B8-C33; A26-B8-C38; A27-B8-C3; A27-B8-C36; A28-B8-C1; A28-B8-C34; A26-B8-C39; 1 A27-B8-C4; A27-B8-C37; A28-B8-C2; A28-B8-C35; A26-B8-C40; A27-B8-C5; A27-B8-C38; A28-B8-C3; A28-B8-C36; A26-B8-C41; A27-B8-C6; A27-B8-C39; A28-B8-C4; A28-B8-C37; A26-B8-C42; A27-B8-C7; A27-B8-C40; A28-B8-C5; A28-B8-C38; A26-B8-C43; A27-B8-C8; A27-B8-C41; A28-B8-C6; A28-B8-C39; A26-B8-C44; A27-B8-C9; A27-B8-C42; A28-B8-C7; A28-B8-C40; A26-B8-C45; A27-B8-C10; A27-B8-C43; A28-B8-C8; A28-B8-C41;

• ·

-212 »··· 9« · ·· · 9 · 9

98 9 9 9 9 9

9 9 9 9 9

A28-B8-C42;

A28-B8-C43;

A28-B8-C44;

A28-B8-C45;

A28-B8-C46;

A28-B8-C47;

A28-B8-C48;

A28-B8-C49;

A28-B8-C50;

A28-B8-C51;

A28-B8-C52;

A28-B8-C53;

A28-B8-C54;

A28-B8-C55;

A28-B8-C50;

A28-B8-C57;

A28-B8-C58;

A28-B8-C59;

A28-B8-C60;

A28-B8-C61;

A28-B8-C62;

A28-B8-C63;

A28-B8-C64;

A28-B8-C65;

A28-B8-C66;

A28-B8-C67;

A28-B8-C68;

(

A29-B8-C1;

A29-B8-C2;

A29-B8-C3;

A29-B8-C4;

A29-B8-C5;

A29-B8-C6;

A29-B8-C7;

A29-B8-C8;

A29-B8-C9;

A29-B8-C10;

A29-B8-C11;

A29-B8-C12;

A29-B8-C13;

A29-B8-C14;

A29-B8-C15;

A29-B8-C16;

A29-B8-C17;

A29-B8-C18;

A29-B8-C19;

A29-B8-C20;

A29-B8-C21;

A29-B8-C22;

A29-B8-C23;

A29-B8-C24;

A29-B8-C25;

A29-B8-C26;

A29-B8-C27;

A29-B8-C28;

A29-B8-C29;

A29-B8-C30;

A29-B8-C31;

A29-B8-C32;

A29-B8-C33;

A29-B8-C34;

A29-B8-C35;

A29-B8-C36;

A29-B8-C37;

A29-B8-C38;

A29-B8-C39;

A29-B8-C40;

A29-B8-C41;

A29-B8-C42;

A29-B8-C43;

A29-B8-C44;

A29-B8-C45;

A29-B8-C46;

A29-B8-C47;

A29-B8-C48;

A29-B8-C49;

A29-B8-C50;

A29-B8-C51;

A29-B8-C52;

A29-B8-C53;

A29-B8-C54;

A29-B8-C55;

A29-B8-C56;

A29-B8-C57;

A29-B8-C58;

A29-B8-C59;

A29-B8-C60;

A29-B8-C61;

A29-B8-C62;

A29-B8-C63;

A29-B8-C64;

A29-B8-C65;

A29-B8-C66;

A29-B8-C67;

A29-B8-C68;

A30-B8-C1;

A30-B8-C2;

A30-B8-C3;

A30-B8-C4;

A30-B8-C5;

A30-B8-C6;

A30-B8-C7;

A30-B8-C8;

A30-B8-C9;

A30-B8-C10;

A30-B8-C11;

A30-B8-C12;

A30-B8-C13;

A30-B8-C14;

A30-B8-C15;

A30-B8-C16;

A30-B8-C17;

A30-B8-C18;

A30-B8-C19;

A30-B8-C20;

A30-B8-C21;

A30-B8-C22;

A30-B8-C23;

A30-B8-C24;

A30-B8-C25;

A30-B8-C26;

A30-B8-C27;

A30-B8-C28;

A30-B8-C29;

A30-B8-C30;

A30-B8-C31;

A30-B8-C32;

A30-B8-C33;

A30-B8-C34;

A30-B8-C35;

A30-B8-C36;

A30-B8-C37;

A30-B8-C38;

A30-B8-C39;

A30-B8-C40;

A30-B8-C41;

A30-B8-C42;

A30-B8-C43;

A30-B8-C44;

A30-B8-C45;

A30-B8-C46;

A30-B8-C47;

A30-B8-C48;

A30-B8-C49;

A30-B8-C50;

A30-B8-C51;

A30-B8-C52;

A30-B8-C53;

A30-B8-C54;

A30-B8-C55;

A30-B8-C56;

A30-B8-C57;

A30-B8-C58;

A30-B8-C59;

A30-B8-C60;

A30-B8-C61;

A30-B8-C62;

A30-B8-C63;

A30-B8-C64;

A30-B8-C65;

A30-B8-C66;

A30-B8-C67;

A30-B8-C68;

A31-B8-C1;

A31-B8-C2;

• 9 9 99 9 9 9

98 9 9 9 9 9

-213 • 99 9 9 9 9 999 9 9 ·

A31-B8-C3;

A31-B8-C4;

A31-B8-C5;

A31-B8-C6;

A31-B8-C7;

A31-B8-C8;

A31-B8-C9;

A31-B8-C10;

A31-B8-C11;

A31-B8-C12;

A31-B8-C13;

A31-B8-C14;

A31-B8-C15;

A31-B8-C16;

A31-B8-C17;

A31-B8-C18;

A31-B8-C19;

A31-B8-C20;

A31-B8-C21;

A31-B8-C22;

A31-B8-C23;

3131-B8-C24;

A31-B8-C2S;

A31-B8-C26;

A31-B8-C27;

A31-B8-C28;

A31-B8-C29;

A31-B8-C30;

A31-B8-C31;

A31-B8-C32;

A31-B8-C33;

A31-B8-C34;

A31-B8-C35;

A31-B8-C36;

A31-B8-C37;

A31-B8-C38;

A31-B8-C39;

A31-B8-C40;

A31-B8-C41;

A31-B8-C42;

A31-B8-C43;

A31-B8-C44;

A31-B8-C45;

A31-B8-C46;

A31-B8-C47;

A31-B8-C48;

A31-B8-C49;

A31-B8-C50;

A31-B8-C51;

A31-B8-C52;

A31-B8-C53;

A31-B8-C54;

A31-B8-C55;

A31-B8-C56;

A31-B8-C57;

A31-B8-C58;

A31-B8-CS9;

A31-B8-C60;

A31-B8-C61;

A31-B8-C62;

A31-B8-C63;

A31-B8-C64;

A31-B8-C65;

A31-B8-C66;

A31-B8-C67;

A31-B8-C68;

A32-B8-C1;

A32-B8-C2;

A32-B8-C3;

A32-B8-C4;

A32-B8-C5;

A32-B8-C6;

A32-B8-C7;

A32-B8-C8;

A32-B8-C9;

A32-B8-C10;

A32-B8-C11;

A32-B8-C12;

A32-B8-C13;

A32-B8-C14;

A32-B8-C15;

A32-B8-C16;

A32-B8-C17;

A32-B8-C18;

A32-B8-C19;

A32-B8-C20;

A32-B8-C21;

A32-B8-C22;

A32-B8-C23;

A32-B8-C24;

A32-B8-C25;

A32-B8-C26;

A32-B8-C27;

A32-B8-C28;

A32-B8-C29;

A32-B8-C30;

A32-B8-C31;

A32-B8-C32;

A32-B8-C33;

A32-B8-C34;

A32-B8-C35;

A32-B8-C36;

A32-B8-C37;

A32-B8-C38;

A32-B8-C39;

A32-B8-C40;

A32-B8-C41;

A32-B8-C42;

A32-B8-C43;

A32-B8-C44;

A32-B8-C45;

A32-B8-C46;

A32-B8-C47;

A32-B8-C48;

A32-B8-C49;

A32-B8-C50;

A32-B8-C51;

A32-B8-C52;

A32-B8-C53;

A32-B8-C54;

A32-B8-C55;

A32-B8-C56;

A32-B8-C57;

A32-B8-C58;

A32-B8-C59;

A32-B8-C60;

A32-B8-C61;

A32-B8-C62;

A32-B8-C63;

A32-B8-C64;

A32-B8-C65;

A32-B8-C66;

A32-B8-C67;

A32-B8-C68;

A33-B8-C1;

A33-B8-C2;

A33-B8-C3;

A33-B8-C4;

A33-B8-C5;

A33-B8-C6;

A33-B8-C7;

A33-B8-C8;

A33-B8-C9;

A33-B8-C10;

A33-B8-C11;

A33-B8-C12;

A33-B8-C13;

A33-B8-C14;

A33-B8-C15;

A33-B8-C16;

A33-B8-C17;

A33-B8-C18;

A33-B8-C19;

A33-B8-C20;

A33-B8-C21;

A33-B8-C22;

A33-B8-C23;

A33-B8-C24;

A33-B8-C25;

A33-B8-C26;

A33-B8-C27;

A33-B8-C28;

A33-B8-C29;

A33-B8-C30;

A33-B8-C31;

-214 * · ♦ ·· · 9 · 9 9

9 9 9 9 9 · · ·

9 9 9 9 9 9

9 9 9 9 9

A33-B8-C32;

A33-B8-C33;

A33-B8-C34;

A33-B8-C35;

A33-B8-C36;

A33-B8-C37;

A33-B8-C38;

A33-B8-C39;

A33-B8-C40;

A33-B8-C41;

A33-B8-C42;

A33-B8-C43;

A33-B8-C44;

A33-B8-C45;

A33-B8-C46;

A33-B8-C47;

A33-B8-C48;

A33-B8-C49;

A33-B8-C50;

A33-B8-C51;

A33-B8-C52;

A33-B8-C53;

A33-B8-C54;

A33-B8-C55;

A33-B8-C56;

A33-B8-C57;

A33-B8-C8;

A33-B8-C59;

A33-B8-C60;

A33-B8-C61;

A33-B8-C62;

A33-B8-C63;

A33-B8-C64;

A33-B8-C65;

A33-B8-C66;

A33-B8-C67;

A33-B8-C68;

A34-B8-C1;

A34-B8-C2;

A34-B8-C3;

A34-B8-C4;

A34-B8-C5;

A34-B8-C6;

A34-B8-C7;

A34-B8-C8;

A34-B8-C9;

A34-B8-C10;

A34-B8-C11;

A34-B8-C12;

A34-B8-C13;

A34-B8-C14;

A34-B8-C15;

A34-B8-C16;

A34-B8-C17;

A34-B8-C18;

A34-B8-C19;

A34-B8-C20;

A34-B8-C21;

A34-B8-C22;

A34-B8-C23;

A34-B8-C24;

A34-B8-C25;

A34-B8-C26;

A34-B8-C27;

A34-B8-C28;

A34-B8-C29;

A34-B8-C30;

A34-B8-C31;

A34-B8-C32;

A34-B8-C33;

A34-B8-C34;

A34-B8-C35;

A34-B8-C36;

A34-B8-C37;

A34-B8-C38;

A34-B8-C39;

A34-B8-C40;

A34-B8-C41;

A34-B8-C42;

A34-B8-C43;

A34-B8-C44;

A34-B8-C45;

A34-B8-C46;

A34-B8-C47;

A34-B8-C48;

A34-B8-C49;

A34-B8-C50;

A34-B8-C51;

A34-B8-C52;

A34-B8-C53;

A34-B8-C54;

A34-B8-C55;

A34-B8-C56;

A34-B8-C57;

A34-B8-C58;

A34-B8-C59;

A34-B8-C60;

A34-B8-C61;

A34-B8-C62;

A34-B8-C63;

A34-B8-C64;

A34-B8-C65;

A34-B8-C66;

A34-B8-C67;

A34-B8-C68;

A35-B8-C1;

A35-B8-C2;

A35-B8-C3;

A35-B8-C4;

A35-B8-C5;

A35-B8-C6;

A35-B8-C7;

A35-B8-C8;

A35-B8-C9;

A35-B8-C10;

A35-B8-C11;

A35-B8-C12;

A35-B8-C13;

A35-B8-C14;

A35-B8-C15;

A35-B8-C16;

A35-B8-C17;

A35-B8-C18;

A35-B8-C19;

A35-B8-C20;

A35-B8-C21;

A35-B8-C22;

A35-B8-C23;

A35-B8-C24;

A35-B8-C25;

A35-B8-C26;

A35-B8-C27;

A35-B8-C28;

A35-B8-C29;

A35-B8-C30;

A35-B8-C31;

A35-B8-C32;

A35-B8-C33;

A35-B8-C34;

A35-B8-C35;

A35-B8-C36;

A35-B8-C37;

A35-B8-C38;

A35-B8-C39;

A35-B8-C40;

A35-B8-C41;

A35-B8-C42;

A35-B8-C43;

A35-B8-C44;

A35-B8-C45;

A35-B8-C46;

A35-B8-C47;

A35-B8-C48;

A35-B8-C49;

A35-B8-C50;

A35-B8-C51;

A35-B8-C52;

A35-B8-C53;

A35-B8-C54;

A35-B8-C55;

A35-B8-C56;

A35-B8-C57;

A35-B8-C58;

A35-B8-C59;

A35-B8-C60;

· *

A35-B8-C61; A36-B8-C26; A36-B8-C59; A37-B8-C24; A37-B8-C57; A35-B8-C62; A36-B8-C27; A36-B8-C60; A37-B8-C25; A37-B8-C58; A35-B8-C63; A36-B8-C28; A36-B8-C61; A37-B8-C26; A37-B8-C59; A35-B8-C64; A36-B8-C29; A36-B8-C62; A37-B8-C27; A37-B8-C60; A35-B8-C65; A36-B8-C30; A36-B8-C63; A37-B8-C28; A37-B8-C61; A35-B8-C66; A36-B8-C31; A36-B8-C64; A37-B8-C29; A37-B8-C62; A35-B8-C67; A36-B8-C32; A36-B8-C65; A37-B8-C30; A37-B8-C63; A35-B8-C68; A36-B8-C33; A36-B8-C66; A37-B8-C31; A37-B8-C64; A36-B8-C1; A36-B8-C34; A36-B8-C67; A37-B8-C32; A37-B8-C65; A36-B8-C2; A36-B8-C35; A36-B8-C68; A37-B8-C33; A37-B8-C66; A36-B8-C3; A36-B8-C36; A37-B8-C1; A37-B8-C34; A37-B8-C67; A36-B8-C4; A36-B8-C37; A37-B8-C2; A37-B8-C35; A37-B8-C68; A36-B8-C5; A36-B8-C38; A37-B8-C3; A37-B8-C36; A38-B8-C1; A36-B8-C6; A36-B8-C39; A37-B8-C4; A37-B8-C37; A38-B8-C2; A36-B8-C7; A36-B8-C40; A37-B8-C5; A37-B8-C38; A38-B8-C3; A36-B8-C8; A36-B8-C41; A37-B8-C6; A37-B8-C39; A38-B8-C4; A36 - BS - C9; A36-B8-C42; A37-B8-C7; A37-B8-C40; A38-B8-C5; A36-B8-C10; A36-B8-C43; A37-B8-C8; A37-B8-C41; A38-B8-C6; A36-B8-C11; A36-B8-C44; A37-B8-C9; A37-B8-C42; A38-B8-C7; A36-B8-C12; A36-B8-C45; A37-B8-C10; A37-B8-C43; A38-B8-C8; A36-B8-C13; A36-B8-C46; A37-B8-C11; A37-B8-C44; A38-B8-C9; A36-B8-C14; A36-B8-C47; A37-B8-C12; A37-B8-C45; A38-B8-C10; A36-B8-C15; A36-B8-C48; A37-B8-C13; A37-B8-C46; A38-B8-C11; A36-B8-C16; A36-B8-C49; A37-B8-C14; A37-B8-C47; A38-B8-C12; A36-B8-C17; A36-B8-C50; A37-B8-C15; A37-B8-C48; A38-B8-C13; A36-B8-C18; A36-B8-C51; A37-B8-C16; A37-B8-C49; A38-B8-C14; A36-B8-C19; A36-B8-C52; A37-B8-C17; A37-B8-C50; A38-B8-C15; A36-B8-C20; A36-B8-C53; A37-B8-C18; A37-B8-C51; A38-B8-C16; A36-B8-C21; A36-B8-C54; A37-B8-C19; A37-B8-C52; A38-B8-C17; A36-B8-C22; A36-B8-C55; A37-B8-C20; A37-B8-C53; A38-B8-C18; A36-B8-C23; A36-B8-C56; A37-B8-C21; A37-B8-C54; 3838-B8-C19; A36-B8-C24; A36-B8-C57; A37-B8-C22; A37-B8-C55; A38-B8-C20; A36-B8-C25; A36-B8-C58; A37-B8-C23; A37-B8-C56; A38-B8-C21;

-216φφφ

A38-B8-C22; A38-B8-C55; A38-B8-C23; A38-B8-C56; A38-B8-C24; A38-B8-C57; A38-B8-C25; A38-B8-C58; A38-B8-C26; A38-B8-C59; A38-B8-C27; A38-B8-C60; A38-B8-C28; A38-B8-C61; A38-B8-C29; A38-B8-C62; A38-B8-C30; A38-B8-C63; A38-B8-C31; A38-B8-C64; A38-B8-C32; A38-B8-C65; A38-B8-C33; A38-B8-C66; A38-B8-C34; A38-B8-C67; A38-B8-C35; A38-B8-C36; A38-B8-C68. A38-B8-C37; A38-B8-C38; A38-B8-C39; A38-B8-C40; A38-B8-C41; A38-B8-C42; A38-B8-C43; A38-B8-C44; A38-B8-C45; A38-B8-C46; A38-B8-C47; A38-B8-C48; A38-B8-C49; A38-B8-C50; A38-B8-C51; A38-B8-C52; A38-B8-C53; A38-B8-C54;

VW * · ί

I ι

- 217

Thus, for example, in the above summary, the compound designated as A1-B1-C1 represents the product obtained by combining the group A1 listed in Table 1 and the group B1 listed in Table 2a of the group C1 listed in Table 3, namely the compound formulas:

Preferred compounds of the present invention are:

3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propionic acid;

3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -butyric acid;

3- (4-Acetyl-1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propionic;

3- (4-Benzoyl-1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxaline-6-yl) -propionic;

4- (7- (2-carboxyethyl) -4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl-3,4-dihydro-2H-quinoxalin-1-yl ) -4 ··

218

-oxo-butyric;

3- (4- (3-dimethylamino-propionyl) -1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro- quinoxalin-6-yl) -propionic;

7- (2-Carboxy-ethyl) -4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-quinoxaline- tert-butyl ester 1-carboxylic;

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -5-methylhexane;

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-phenylpropane;

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-o-tolyl-propane;

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -butan;

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -4-methyl-pentanoate;

3- (4-Benzoyl-1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -butter;

219

·· and corresponding! N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and N-oxides and prodrugs thereof.

Particularly preferred compounds of the present invention are:

3- (1 - {[3-methoxy-4- (3- [2-methylphenyl] -ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propionic acid ;

3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -butyric acid;

7- (2-Carboxy-ethyl) -4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-quinoxaline- tert-butyl ester 1-carboxylic;

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -5-methylhexane;

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-phenylpropane;

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-o-tolyl-propane;

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -butan;

• ·

220 ·· »

3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazine-7- yl) -4-methylpentanoic acid;

and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and N-oxides and prodrugs thereof.

The compounds of the present invention exhibit useful pharmacological activity and, therefore, can be formulated as pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. The present invention therefore further relates to a further aspect of the compounds as defined above and compositions comprising the compounds of the invention for use in therapy.

The compounds within the scope of the present invention block the interaction of VCAM-1 ligand with its integrin receptor VLA-4 (α4β1), as shown by prior art assays and in vivo and in vitro assays. are described below, wherein these assays correlate with pharmacological activity in humans and other animals. Accordingly, in a further aspect, the present invention relates to compounds and compositions comprising the compounds of the invention for use in treating patients suffering from or susceptible to a disease state that can be alleviated by administration of an α4β1 mediated cell adhesion inhibitor. For example, the compounds of the present invention are useful in the treatment of inflammatory

221

diseases such as joint inflammation, including arthritis, rheumatoid arthritis, and other arthritic conditions such as rheumatoid spodylitis, gouty arthritis, traumatic arthritis, rubella arthritis, psoriatic arthritis, and osteoarthritis. In addition, the compounds of the invention can be used to treat acute synovitis, peripheral vascular events, cardiovascular disease, multiple sclerosis, asthma, psoriatic restenosis, myocarditis, inflammatory bowel disease and melanoma cell division in metastasis.

According to a particularly preferred embodiment of these therapeutic methods, the present invention relates to the treatment of asthma.

According to another particularly preferred embodiment of these therapeutic methods, the present invention relates to the treatment of inflammatory bowel disease.

In another aspect, the present invention relates to a method of a human individual or animal as a patient suffering from or susceptible to a disease state which may be alleviated by administering a VCAM-1 ligand interaction inhibitor to its VLA-4 (α4β1) integrin receptor, for example supra, comprising administering to said patient an effective amount of a compound of the invention or a composition comprising a compound of the invention. The term "effective amount" means a minimal amount of a compound of the present invention that is effective to inhibit the interaction of VCAM-1 ligand on its VLA-4 (α4β1) integrin receptor and thereby elicit the desired therapeutic effect.

As used herein

222 <

<

treatment, then both prophylactic therapy and treatment of the developed state.

The present invention also provides pharmaceutical compositions comprising at least one compound of the invention in association with a pharmaceutically acceptable carrier or excipient.

The compounds of the present invention may be administered in any suitable form and in any suitable composition. In practice, the compounds of the invention may generally be administered parenterally, topically, rectally, orally, or by inhalation, particularly orally.

The compositions of the present invention may be prepared by conventional methods using one or more pharmaceutically acceptable adjuvants or excipients. Adjuvants include, but are not limited to, diluents, sterile aqueous media, and various non-toxic organic solvents. The compositions may be in the form of tablets, pills, granules, powders, aqueous solutions or suspensions, injectable solutions, elixirs or syrups, which may contain one or more agents selected from the group consisting of sweetening, flavoring, coloring and stabilizing agents, the purpose is to obtain pharmaceutically acceptable compositions. The choice of vehicle and the active ingredient content of the vehicle will generally be determined by the solubility and chemical properties of the active agent, the particular mode of administration, and the usual rules of pharmaceutical practice. Lactose, sodium citrate, calcium carbonate, calcium phosphate and disintegrating agents such as

223 i:

Starch, alginic acid and certain complex silicates in combination with lubricants such as magnesium stearate, sodium lauryl sulfate and talc. Preferably, lactose and high molecular weight polyethylene glycols may be used to prepare the capsules. If aqueous suspensions are used, they may contain emulsifying agents or suspending agents. Diluents such as sucrose, ethanol, polyethylene glycol, propylene glycol, glycerol and chloroform or mixtures thereof may also be used.

For parenteral administration, emulsions, suspensions, or solutions of the compounds of the present invention in a natural oil, such as sesame oil, peanut oil or olive oil, or aqueous-organic solutions such as water and propylene glycol, injectable organic esters such as ethyl oleate as well as sterile aqueous solutions of pharmaceutically acceptable salts. Salts of the compounds of the present invention are particularly suitable for administration by intramuscular or subcutaneous injection. Aqueous solutions can also be used for intravenous administration, which also include solutions of salts in pure distilled water, provided that their pH is appropriately adjusted and that they can be further buffered as desired, and isotonic solutions can be prepared therefrom. a sufficient proportion of glucose or sodium chloride, and further provided that they can be sterilized by heating, irradiation or microfiltration.

For topical administration, gels (aqueous or alcohol based), creams or ointments containing the compounds of the present invention may be used.

9 9 · i i i i i f f f f f f f f f f f f f f f f f

224

The compounds of the present invention may also be incorporated in the form of a gel or matrix base on patches, by controlling the release of the compound across the transdermal barrier.

When the compounds of the invention are administered by inhalation, they can be dissolved or suspended in a suitable carrier and used as a nebulizer or suspension or aerosol solution, or can be absorbed or adsorbed on a suitable solid carrier and used. in the form of dry powder for inhalers.

Solid formulations for rectal administration include suppositories formulated by conventional methods of the prior art containing at least one compound of the present invention.

The percentage of active ingredient in the composition of the present invention may vary considerably as desired to provide a suitable dosage of the compound of the present invention. Usually, several dosage forms may be administered at approximately the same time intervals. The dose employed may be determined by the attending physician, depending upon the desired therapeutic effect, the method of administration and the duration of treatment, as well as the condition of the patient. For adult patients, the dose is generally in the range of about 0.001 to about 50 milligrams / kilogram body weight, preferably about 0.001 milligrams to about 5 milligrams per kilogram body weight for inhalation, in the range of about 0.01 milligrams to about 5 milligrams per kilogram body weight. about 100 milligrams per kilogram of body weight, preferably about 0.1

225

4 4

• 4 4 • 4 4 4

4 44 • 4

4 «6

4 4

4 to 4 milligrams to about 0.1 milligrams to 70 milligrams per kilogram of body weight, particularly 0.5 milligrams to about 10 milligrams per kilogram of body weight per day for oral administration, and in the range of about 0.001 milligrams to about 10 milligrams, preferably performing about 0.01 milligram to about 1 milligram per kilogram of body weight per day by intravenous administration. In each individual case, this dose will depend on factors that are critical for each subject being treated, i.e., the patient's age, weight, general health, and other characteristics that may affect the efficacy of the pharmaceutical product.

The compounds of the present invention may be administered as often as necessary to obtain a therapeutic effect. In some patients, the response may occur very quickly to both high doses and low doses, so that they can be adequately chosen with much weaker acting doses. In the case of other patients, the use of long-term treatment in an amount ranging from 1 dose to 4 doses per day may be contemplated according to the physiological requirements of each individual patient. In general, the active ingredient may be administered orally one to four times a day. Of course, for some patients, it will be necessary to prescribe a maximum of one or two doses per day.

The compounds of the present invention can be prepared by applying or adapting well-known methods known in the art to mean methods which have hitherto been used or described in the literature, such as those described in R.C. Larock, Comprehensive Organic Transformations, VCH Publishers, 1989.

9 * ♦ «• · · ·

226

In carrying out the reactions described herein, it may be necessary to protect reactive functional groups such as hydroxy, amino, imine, thio, or carboxy, when required to be present in the final product, to prevent unwanted participation in the reactions.

In these cases, commonly known and used protecting groups may be employed using conventional methods known in the art, such as T. W. Greene, P.G.M. Wuts, Protective Groups in Organic Chemistry, John Wiley &amp; Sons, 1991.

Compounds of formula I in which R ¹ , R ² , A ¹ , L ¹ and Z ¹ have the same meaning as previously described and Y is carboxy may be prepared by hydrolyzing esters of a compound of formula I wherein R 1 is R ^2, N, ΐΛ and 70 have the same meanings as above and Y is -CO ^ i * ⁰ (in which R ^3-0 represents alkyl, alkenyl or arylalkyl). The hydrolysis can be carried out in a conventional manner by alkaline hydrolysis using a base such as an alkali metal hydroxide such as lithium hydroxide or an alkali metal carbonate such as potassium carbonate in the presence of a mixture of water and an organic solvent using such organic solvents. solvents such as dioxane, tetrahydrofuran or methanol, and is operated at a temperature in the range of about ambient temperature to about the reflux temperature of the solvent used. Hydrolysis of the esters can also be carried out by acid hydrolysis using an inorganic acid such as an acid

227 hydrochloric acid, in the presence of a mixture of water and an inert organic solvent such as dioxane or tetrahydrofuran, is operated at a temperature in the range of about 50 ° C to about 80 ° C.

Another example is the preparation of compounds of formula (I) of the present invention in which:

R ⁴ , R ² , A ⁴ , L ⁴ and Z ⁴ are as defined above, wherein

Y represents a carboxy group consisting of the removal of the tertiary butyl group of the tert-butyl esters of the compound (I) of formula (I) in which R, R, A, L and Z are as defined above and Y represents a -CO ₂ R ⁴ group; (wherein R ⁴ is tert-butyl) by acid catalysis using standard reaction conditions generally used and known in the art, for example, reaction with trifluoroacetic acid at about ambient temperature.

Another example is the preparation of compounds of formula I wherein R ⁴ , R ² , and ⁴ , L ⁴ and Z ⁴ are as defined above, wherein Y is a carboxy group, which is carried out by hydrogenation of compounds of formula I, in which R ^4, R ^2, a ^4, L ⁴ and Z ⁴ are as defined above and Y is-CC ^ R ^ ⁴ (in which R ⁴⁶ is -CO ₂ R ⁴ H, wherein R @ ⁴ represents an arylmethyl group such as a benzyl group). This reaction may be carried out in the presence of ammonium formate and a suitable metal catalyst such as palladium supported on an inert support such as carbon, preferably in a solvent such as methanol or ethanol and at about the reflux temperature of the solvent used. This

Alternatively, the reaction may be carried out in the presence of a suitable metal catalyst, such as platinum or palladium, optionally deposited on an inert support material such as carbon, preferably in a solvent such as methanol or ethanol. This reaction is most suitable for the preparation of compounds of formula (I) in which the LA does not contain carbon-carbon multiple bonds.

Using process A to prepare compounds of formula I of the present invention containing an amide bond, the acid (or acid halide or anhydride) is added to the amine using standard peptide bonding conditions, which will be described further to provide amide bond.

An example of this process A is a process wherein the esters of a compound of formula I wherein R ² , A, and A are as defined above, R 4a and a group selected from the group consisting of R 2 -R ³ -L ² -R ⁴ -Z ³ -, R ³ -L ³ -Ar ¹ -L ⁴ -Z ³ - and R ³ -L ³ -Ar ¹ -L ² -R ⁴ -Z ³ - (in which R, R, L , L, L and Ar have the same meaning as previously defined and Z ³ represents a group C (= O) and Y represents a group-CC ^ R ^ (in which R ^ ³ represents a -CC ^ R ^ group in which R ^ Has the same meaning as above), by reacting a compound of formula (II):

r18_ _C ( _{= Q} ) _ _X 1 (II) in which:

R ¹⁸ represents a group R ³ -, R ³ -L ² -R ⁴ -, R ³ -L ³ -Ar ¹ -L ⁴ - or R ³ -L ³ -Ar ¹ -L ² -R ⁴ - (in which R ³ , R ⁴ , L ² , L ³ , Ar 1 and L ⁴ ) have the same meaning as previously defined), and

229 χΐ represents hydroxy, halogen, preferably chlorine, or -0-C (= 0) -R * · ⁰ - with an amine of formula III:

* · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

(III) o < i &lt; 11 &gt; in which R, R, A, L and Z ^{x have the} same meaning as previously defined. When X ¹ is hydroxy, this reaction can be performed using standard peptide bonding conditions, for example, coupling in the presence of O- (7-azabenzotriazol-1-yl) -1,1,3,3-tetramethyluronium hexafluorophosphate in tetrahydrofuran (or dimethylformamide) ), which is carried out at ambient temperature.

When X is a halogen atom, the acylation reaction is carried out using a base such as pyridine, preferably in a solvent such as tetrahydrofuran and at a temperature approximately equal to ambient temperature. When X ¹ is -O-C (= O) -R ⁸ -, the reaction is carried out in an inert solvent such as dichloromethane, optionally in the presence of a base such as triethylamine, and at a temperature approximately equal to the temperature rooms.

Esters of the compounds of formula (I) in which R1, R1, A1 and Z1 are as defined above, wherein Y is -CO ₉ -R16 (in which R1 is as defined above) and L ^x contains -N (R °) -C (= O) -R 4 (wherein R ⁸ and R ⁹ have the same meaning as previously defined

230

from above), can be prepared in a similar manner from the corresponding esters of compounds of formula I in which 1 / contains the group -NHR ° (in which R ° is as defined above) by reaction with a compound of formula

R ⁹ -C (= O) -X ¹ wherein R ⁹ and X ¹ have the same meaning as previously defined.

O

Esters of the compounds of formula I in which R,

A ¹ , L ¹ and Z ¹ have the same meaning as above, R ¹ represents an α α group selected from the group consisting of R -ZR ³ -L ² -R ⁴ -Z ³ -, R ³ -L ³ -Ar ¹ -L ⁴ -Z ³ - and R ³ -L ³ -Ar ¹ -L ² -R ⁴ -Z ³ - (in which R ³ , R ⁴ , L ² , L ³ , L ³ and Ar ¹ have the same meaning as previously defined and Z ³ is SO ₂ ) and Y is -CO ₂ R ¹⁶ (wherein R ¹⁶ has the same meaning as previously defined) may be prepared by sulfonylation of compounds of formula III wherein R ² , R ¹⁶ , A ¹ , L ¹ and Z ¹ have the same meaning as previously defined using the sulfonyl chloride of formula IV:

R ¹⁸ -SO ₂ -C1 (IV) wherein R ¹⁸ has the same meaning as previously described. This reaction is preferably carried out using a base such as a tertiary amine, for example triethylamine, preferably in a solvent such as is, for example, tetrahydrofuran, and at a temperature ranging from about 0 ° C to about room temperature.

Esters of the compounds of formula I in which R ¹ ,

231 * ·

R ?, and Z ³ have the same meaning given above, Y represents a '1 A 1 A group -C02R ^{± d} (in which R ° has the same meaning as QQ 1 described above) and L comprises a group -N (R ^a) - S0 ₂ -R (where R 8 and R ⁹ have the same meanings as defined above) can be prepared in a similar manner as the corresponding esters -1 of formula I in which L contains a -NHR o (where R & is the same as as defined above) by reaction with sulfonyl chlorides of the general formula R ⁹ -so ₂ or wherein R ⁹ has the same meaning as previously defined.

O

Esters of the compounds of formula I in which R,

A ¹ , L ¹ and have the same meaning as previously defined, R ¹ represents a group R ³ -L ³ -Ar ⁴ -L ⁴ -Z ³ - (in which R ³ , L ³ , L ⁴ and Ar ⁴ have the same as defined above, Z represents a group

NHC (= O) and Y is -CO ₂ R 4 * (where R ¹ is as defined above) may be prepared

By reacting compounds of formula III in which R, A, L, zA and r16 have the same meaning as previously defined with an isocyanate of formula V:

R ³ -L ³ -Ar ¹ -L ⁴ -NCO (V) wherein R ³ , L ³ , L ⁴ and Ar ^{1 have the} same meaning as previously defined. This reaction is preferably carried out with a base such as a tertiary amine, for example triethylamine, preferably in a solvent such as dichloromethane, and at a temperature approximately equal to room temperature.

O

Esters of the compounds of formula I in which R,

232

A ¹ , L ¹ and Z ¹ have the same meaning as previously defined, R ¹ represents a group R ³ -Z ³ - [in which R ³ has the same meaning as defined above and Z ^J represents a group NHC (= O)] can be prepared in a similar manner by reacting a compound of the general formula I 1 Ί 1 A of the formula III in which R, A ^x , L, Z and R ° have the same meaning as defined above with an isocyanate of the formula

R ³ -NCO wherein R ³ has the same meaning as previously defined.

Esters of the compounds of formula I in which R,

A ¹ , L ¹ and Z ¹ have the same meaning as above, R ¹ represents a group R ³ -Z ³ - (in which R ³ has the same meaning as previously defined [except for the aryl and heteroaryl groups] and Z ³ represents a direct bond wherein Y is -CO ₂ R ¹⁶ (in which R ¹ is as defined above) may be prepared by alkylation of a compound of formula III wherein R ² , A ¹ , L ¹ , Z ¹ and R ¹ ; have the same meaning as defined above with the compound of formula (VI):

R ³ -X ² (VI) wherein R ³ is as defined immediately above, and X ² is halogen, preferably bromine. For example, the alkylation may be carried out in the presence of a base such as an alkali metal hydride such as sodium hydride in dimethylformamide or dimethyl sulfoxide at a temperature ranging from about 0 ° C to about 100 ° C.

O

Esters of the compounds of formula I in which R,

233 • · 9 · 9 ·

Α ·, ·, ΐΛ and Z ¹ have the same meaning as previously defined, R ⁴ represents 3043 a group selected from the group consisting of R -L -R -Z-, R ³ -L ⁴ -Ar ¹ -L ⁴ -Z ³ -, R ³ -L ⁴ -Ar ¹ -L ² -R ⁴ -Z ³ - and R ³ -L ³ -Ar ¹ -L ⁴ -Z ³ - (in which R ³ , L ³ , and Ar · '· have the same meaning as defined above, L ⁴ represents an alkylene group, an alkenylene group or an alkylene group and Z represents a direct bond) and Y represents a -CC 1 R 4 group (in which R 4 ' ³ has the same meaning as defined above) is can be prepared in a similar manner by alkylation of a compound of formula III in which R ² , A '', ΐΛ, and R 6 have the same meaning as previously defined with a compound of formula VIa:

R ¹⁸ -X ² (VIa) wherein R ⁸ is R ³ -L ² -R ⁴ -, R ³ -L ³ -Ar ¹ -L ⁴ - or R ³ -L ³ -Ar ¹ -L ² - R ⁴ - (wherein R ³ , R ⁴ , L ² , L ³ , Ar ¹ and L ⁴ have the same meaning as previously defined) and X is halogen, preferably bromine.

2

Esters of compounds of formula I wherein R, R, A '' and Z ¹ are as previously defined;

Y is -CO ² R ¹ ^ (wherein R ¹ ^ has the same meaning as previously defined) and ΙΛ comprises an -NHR group (wherein R ⁸ represents an alkyl, arylalkyl, cycloalkyl, heteroarylalkyl or heterocycloalkylalkyl group) they can be prepared in a similar manner by alkylation of the corresponding derivative of formula I in which ΐΛ contains the group -NH 2 with a suitable alkyl halide (or arylalkyl halide, cycloalkylalkyl halide, heteroarylalkyl halide or heterocycloalkylalkyl halide).

1

Esters of the compounds of formula I wherein R, A,

234 a · ···

L ¹ and Z ¹ have the same meaning as previously defined, R ¹ and -2 and represent a group from the group R -Z - [in which R has the same meaning as defined above and Y represents a group OC (= O)] reacting a compound of formula III in which R ^2, a ^1, L ^1, R ¹ and Z ^lt> have the same meanings as defined above with a compound of formula VII:

R ³ -OC (= O) -X ³ (VII)

O 2 in which R 0 is as defined above and X represents a halogen atom, preferably a chlorine atom, or -OC (= O) -OR ⁹ in the presence of a suitable basic agent such as triethylamine or pyridine, and at a temperature ranging from about 0 ° C to about room temperature.

2

Esters of the compounds of formula I wherein R, R, A ¹ and Z ¹ have the same meaning as previously defined,

Y is -CO ₂ R ¹⁶ (wherein R ¹ is as defined above) and L ¹ contains -N (R ⁸ ) -C (= O) -OR ⁹ (wherein R ⁸ and R ⁹ are as defined above), can be prepared in a similar manner from the corresponding derivatives of formula I wherein L ¹ contains the group -NHR ⁸ (wherein R ⁸ has the same meaning as defined above) by reaction with compounds of formula:

R ⁹ OC (= O) -X ³ wherein R ⁹ and X ³ have the same meaning as previously defined.

2

Esters of the compounds of formula I wherein R, R, A ¹ and Z ¹ have the same meaning as previously defined,

235

ΙΑ ΊΑ

Υ represents the group -CO ₂ R ° (in which R has the same meaning as defined above) and L ⁴ represents the group -CH-CH ₂ - (or -CH-CH ₂ -)

II nh ₂ nh ₂ can be prepared by hydrogenation of the corresponding derivatives of compounds of formula I in which L ⁴ represents a group -CH-CH ₂ -

AND

N (CH ₂ Ph) ₂ —CH — CH— (or group J) ^CH 3 <.

CH CH.

I I

Ph ph

This reaction may be carried out in the presence of formic acid and a suitable metal catalyst, such as platinum or palladium optionally deposited on an inert support material such as carbon, preferably in a solvent such as methanol or ethanol.

2

Esters of compounds of formula I wherein R, R,

A ⁴ and Z ⁴ have the same meaning as defined above,

Ί A Ί A

Y is -CO ₂ R ^xo (in which R ° has the same meaning as defined above) and L ⁴ is

- 236

-CH-CH ₂ - (CH or CH ₂₎

I nh ₂ nh ₂ can also be obtained from the corresponding racemic mixture by standard recrystallization of a suitable salt (such as tartrate salt recrystallization) or by applying standard enzymatic cleavage procedures (for example, as described in Soloshonok, VA et al., Tetrahedron Asymmetry 6). (1995) 7, 1601-1610.

9

Esters of compounds of formula I wherein R, R,

A and Z ^x have the same meaning as defined above,

Y is -CO ₂ R ¹ ^ (wherein R ¹ ^ has the same meaning as previously defined) and L ¹ is -CH-CH ₂ -

AND

N (CH ₂ Ph) ₂ (or —CH — CHch ₃ <.

CH

AND

Ph

Γ ²

Ph can be prepared by reacting an ester of a compound of formula Ί 1 L

I, in which R, R, A and Z ^x have the same meaning as previously defined, Y represents a group -CO ₂ R ° (in which R has the same meaning as defined above) and ΐΛ represents • ·

A -CH = CH- group with an alkali metal hydride such as sodium hydride in an inert solvent such as tetrahydrofuran at a temperature approximately equal to room temperature, followed by reaction with the anion derived from the dibenzylamine treatment, or (S) -N-benzyl-α-methylbenzylamine with butyllithium at about -78 ° C.

2

Esters of compounds of formula I wherein R, R,

A ¹ and ΐΛ have the same meaning as defined above, “1 A 1 A

Y represents a group -CO-R ⁰ (in which R ⁰ has the same meaning as defined above), and 70 represents the group NH may be prepared by reductive cyclisation of a compound of formula VIII:

(Vin) wherein R ¹ , R ^{2 * * * *} , R ¹ ^, A ¹ and mají have the same meaning as previously described. This reaction can be carried out in a conventional manner using stannous chloride in the presence of hydrochloric acid at a temperature of up to about 80 ° C.

2

Esters of compounds of formula I wherein R, R,

A ¹ and L ¹ have the same meaning as defined above,

Y is -CC (R ¹⁰⁾ (wherein R 0 is as defined above) and L ¹ is alkenylene, alkynylene, or cycloalkenylene

238 • φ φ ΦΦ a group in which an aliphatic carbon-carbon multiple bond is attached directly to the phenyl moiety of formula I can be prepared by coupling compounds of formula IX:

In which R, R, A and Z have the same meaning as above and X ⁴ represents a halogen atom, preferably a bromine or iodine atom, with a compound of the formula X:

R ¹⁹ -CO ₂ R ¹⁶ X

And wherein R ^{10 has the} same meaning as previously defined and R ¹⁹ is alkenyl, alkynyl or cycloalkenyl. When X ⁴ is bromine or iodine, the reaction may be carried out in the conventional manner in the presence of palladium acetate, a triarylphosphine compound such as tri-o-tolylphosphine, and a tertiary amine such as tributylamine at a temperature in the range up to about Mp 110 ° C. This reaction is particularly suitable for the preparation of esters of the compounds of formula I in which A is a vinylene group. When X ⁴ is a chlorine atom, this reaction may be carried out in the usual manner in the presence of sodium iodide, nickel bromide, bis (dibenzylideneacetone) palladium, triarylphosphine such as tri-o-tolylphosphine and a tertiary amine such as tributylamine temperature range up to • · · · ·

• ·

239 ° C approximately 110 ° C.

According to another aspect of the present invention, the compounds of the present invention may be prepared by mutual conversion from other compounds of the present invention.

For example, compounds of formula (I) of the invention wherein R, R, A, L and Ζ ^{χ have the} same meaning as previously defined and Y is -C (= O) -NHOH can be prepared by reaction of a compound of formula I formula I in which R @ ^, R ^3, a · * · and Z is as defined as defined above and Y is carboxy with hydroxylamine using standard well known peptide coupling methods such as treatment with a carbodiimide, for example, dicyclohexylcarbodiimide may be used in the presence of triethylamine in an inert solvent such as dichloromethane or tetrahydrofuran at a temperature approximately equal to room temperature. This coupling reaction can also be carried out using

1-hydroxybenzotriazole and 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide in dichloromethane at room temperature. This preparation can also be carried out using

O-protected hydroxylamine; or

O- (tetrahydropyranyl) hydroxylamine followed by acid treatment.

A further example of a process for the mutual conversion of compounds of the present invention is a process wherein compounds of Formula I of the present invention that contain a sulfoxide bond can be prepared from the corresponding compounds containing an -S-bond. For example, this oxidation can be carried out in a conventional manner by reaction with a peracid, such as

240, for example, 3-chloroperbenzoic acid, preferably in an inert solvent such as dichloromethane, preferably at or near ambient temperature. or alternatively using potassium peroxymonosulphate and in a medium such as aqueous methanol buffered to about pH 5 at a temperature in the range of about 0 ° C to room temperature. This latter method is advantageous for the preparation of compounds containing labile acidic groups.

A further example of a process for the mutual conversion of compounds of the present invention is the process wherein compounds of Formula I of the present invention which contain a sulfone linkage can be prepared by oxidation of the corresponding compounds containing a -S- or sulfoxide linkage. For example, the oxidation can be carried out in a conventional manner using a reaction with a peracid such as an acid

3-chloroperbenzoic acid, preferably in an inert solvent such as dichloromethane, preferably at or near room temperature.

Another example of a process for the conversion of compounds of the present invention is the process wherein the compounds of Formula I of the present invention wherein R ⁴ ,

R, A ¹ , Z, and Y have the same meaning as previously defined and L ⁴ is an optionally substituted alkylene group, prepared by hydrogenation of the corresponding compounds of formula I wherein L ⁴ is a corresponding optionally substituted alkenylene group. This hydrogenation can be carried out using hydrogen (optionally under hydrogen pressure)

241

in the presence of a suitable metal catalyst such as platinum or palladium, optionally supported on an inert support material such as carbon, preferably in a solvent such as methanol or ethanol and at a temperature approximately equal to room temperature.

As another example of a process for the conversion of compounds of the present invention, one may include a process wherein the compounds of Formula I of the present invention wherein R ¹ ,

R, A, L and Z have the same meaning as defined above, L is an alkylene group substituted by -CONY Y and Y is carboxy, prepared by reaction of compounds of formula I wherein R ⁴ , R ² , A ¹ , L ¹ and have the same meaning as defined above, ΐΛ represents an alkylene group substituted with -CO ₂ H and Y represents a carboxy group, with an anhydride such as trifluoroacetic anhydride in an inert solvent such as tetrahydrofuran, followed by treatment with an amine HNY ¹ Y ² .

Another example of a process for the conversion of compounds of the present invention is the process wherein the compounds of Formula I of the present invention wherein R ⁴ ,

1 1

R, A and Z have the same meanings as defined above, ΐΛ is -CH-CH ₂ -

I _{2 2 2} h and Y represents a carboxy group, prepared by (i) reaction of an ester of a compound of formula I, i

Wherein R, R, A, and Z have the same meaning as before

«· • • · · ·

• as defined above, L ¹ represents the group -CH = CH- and Y represents the group -CO ₂ R ¹ ^ (in which R ¹ ^ has the same meaning as defined above), with dimethyl malonate in the presence of an alkoxide an alkali metal, such as sodium methoxide, in methanol and at a temperature approximately equal to the reflux temperature, and (ii) treating the resulting compound of formula I so obtained, wherein R, R, A and Z have the same meaning as previously defined from above, L ¹ is -CH-CH ₂ -

AND

CH (CO ₂ Me) ₂

6 and Y is -CO ₂ R °, hydrochloric acid at reflux.

A further example of a process for the mutual conversion of compounds of the invention is the process wherein compounds of formula I of the invention wherein the heteroatom is a nitrogen atom can be prepared by oxidation to their corresponding N-oxides. The oxidation may conveniently be carried out by reaction with a mixture comprising hydrogen peroxide and an organic acid, such as acetic acid, preferably at or above room temperature, for example at a temperature in the range of about 60 to 90 ° C. . Alternatively, the oxidation may be carried out by reaction with a peracid such as peracetic acid or m-chloroperbenzoic acid in an inert solvent such as chloroform or dichloromethane at a temperature of about room temperature to reflux, preferably execution at elevated temperature. This oxidation is

243 may alternatively be performed by reaction with hydrogen peroxide in the presence of sodium tungstate at a temperature ranging from room temperature to about 60 ° C.

Another example of a process for converting the compounds of the present invention is the process wherein the compounds of formula I of the present invention wherein Z ⁴ is NR ', wherein R is hydrogen, can be prepared by removing the tert-butyloxycarbonyl group in the ester of the compound. of formula I wherein Z ⁴ is

The reaction can be carried out in a conventional manner using trifluoroacetic acid in an inert solvent such as dichloromethane at a temperature of about 0 ° C.

In the case of the compounds according to the invention, it is advantageous to have asymmetric centers. These asymmetric centers may independently be either the R-configuration or the S-configuration. It will be apparent to those skilled in the art that certain compounds of the present invention may also exhibit geometric isomerism. In this connection, it is to be understood that all individual geometric isomers and stereoisomers and mixtures thereof of the present invention of formula I, including racemic mixtures, are within the scope of the present invention. These isomers may be separated from their mixtures using conventional methods for similar purposes or modified processes, for example by chromatographic methods and recrystallization processes, or may be prepared separately from suitable isomers of their intermediates.

.1

244

In another aspect, the acid addition salts of the compounds of the present invention can be prepared by reacting the free bases with a suitable acid using conventional methods or methods adapted to those skilled in the art. For example, the acid addition salts of the compounds of the invention may be prepared either by dissolving the free base in water or an aqueous alcoholic solution or other suitable solvents containing a suitable acid and separating the salt thus obtained by evaporating the solution, or using the free base reactions. and acids in an organic solvent, in which case the salt is separated directly or can be obtained by concentrating the solution.

Acid addition of the salts of the compounds of the present invention can be regenerated from the salts by conventional methods known in the art or by modified methods. For example, the parent compounds of the present invention can be regenerated from their acid addition salts by treatment with an alkaline reagent, such as an aqueous sodium bicarbonate solution or an aqueous ammonia solution.

The compounds of the present invention can be regenerated from their base addition salts using conventional methods or modified methods. For example, the base compounds of the invention can be regenerated from their base addition salts by treatment with an acid such as hydrochloric acid.

The compounds of the present invention may be conventionally

245

• * φ φφφ

by a process to prepare or obtain solvates (such as hydrates) during the process of the invention. Hydrates of the compounds of the present invention can be prepared in a conventional manner by recrystallization from a mixture of water and an organic solvent using dioxane, tetrahydrofuran or methanol as the organic solvent.

In another aspect, the base addition salts of the compounds of the present invention can be prepared by reacting the free acid with a suitable base, using any of the known methods or a modified method. For example, the base addition salts of the compounds of the present invention are prepared either by dissolving the free acid in water or an aqueous alcoholic solution or in another suitable solvent containing the appropriate base, then separating the salt by evaporating the solution, or by reacting the free acid. and a base in an organic solvent, in which case the salt is separated directly or can be obtained by concentrating the solution.

The starting materials and intermediates may be prepared by applying conventional methods known in the art or by modified methods such as those described in the Reference Examples or by chemically similar methods.

R

Compounds of formula (II) in which R represents a group R 1 -A-Ar 1 -L ⁴ - [(wherein R ³ and L ⁴ have the same meaning as previously defined, L is NH, Ar represents a group "r") t · ·

246 i · ♦

(Wherein R is as defined above)] and X ⁴ is hydroxy may be prepared by reacting a compound of Formula 1:

wherein R ⁴ and L ^{4 have the} same meaning as previously defined, R ⁴ is a lower alkyl group and X is O, with isothiocyanates of the general formula:

R ³ -N = S = O (wherein R ⁴ has the same meaning as previously defined), in ethanol and at room temperature, followed by reaction with a carbodiimide, such as dicyclohexylcarbodiimide or diisopropylcarbodiimide, in ethanol and at a temperature ranging ranging from about room temperature to reflux, followed by hydrolysis carried out under standard conditions, such as those set forth above.

R

The acids of formula II, in which R ^o is a group R ⁴ -L -Ar -L ⁴ - [(in which R ⁴ and L have the same meaning • ♦

I ϊ

As defined above, Ar ¹ represents a group

(wherein R has the same meaning as previously described), is NH and znamená · znamená represents hydroxy] can be prepared in a similar manner from compounds of formula (1) in which R, L ⁴ and R mají have the same meaning as as defined above and X is NH.

Acid chlorides of the formula II in which R is as defined above and X ³ is a chlorine atom can be prepared from the corresponding acids of the general formula

Wherein R 0 is as defined above and X 1 is hydroxy, using conventional standard methods known in the art and used to convert acids to acid chlorides, for example by reaction with oxalyl chloride.

Compounds of formula III in which R, R- ¹ ,

A ¹ , L ¹ and Z ¹ have the same meaning as defined above, and can be prepared by removing the tert-butyloxycarbonyl group of a compound of the formula:

(2)

9 «β

9 • 9 ·

248

Wherein R, R, A, L and Z have the same meaning as previously defined, and R is -COO Bu, using acid catalysis. This reaction can be conveniently carried out using trifluoroacetic acid in an inert solvent such as dichloromethane and at about 0 ° C. This reaction is particularly suitable for the preparation of 11 compounds of formula III in which Z ^x is and A is an ethylene group.

1

Compounds of formula III in which R, A and Z- ¹ have the same meaning as previously defined, R ¹⁰ is alkyl and L ⁴ is alkylene or cycloalkylene may be prepared by hydrogenation of compounds of formula 2 wherein R, And “1 Ί <

Z and ^A have ^the same meanings as defined above, R °

9Ω represents an alkyl group, R ^υ represents a hydrogen atom [or a protecting group (such as a benzyl group which can be conveniently removed during hydrogenation)] and L ⁴ represents an alkenylene group, an alkynylene group or a cycloalkenylene group. The hydrogenation may be carried out using hydrogen (optionally under pressure) in the presence of a suitable catalyst such as palladium hydroxide supported on an inert support such as carbon in an acetic acid medium and optionally in the presence of a co-solvent such as for example methanol or ethanol, and at a temperature corresponding to approximately room temperature. This reaction is particularly suitable for the preparation of compounds of formula (III) wherein Z ⁴ is N-CC 1 Bu and A ⁴ is ethylene.

Compounds of formula 2 wherein R ² have the same meanings as defined above, R

A ⁴ and Z ⁴ represent

249

An alkyl group, R is a suitable protecting group, such as a tert-butyloxycarbonyl group, and L ¹ is an alkylene group or a cycloalkylene group, can be prepared by reducing the compounds of formula 2 wherein R is ² , A ¹ and Z ¹ have the same meaning as previously defined, R ¹ represents an alkyl group, R ² represents a suitable protecting group such as a tert-butyloxycarbonyl group, and L ¹ represents an alkenylene group, an alkynylene group or a cycloalkenylene group . The reduction may be carried out in the presence of ammonium formate and a suitable metal catalyst such as palladium on an inert support such as carbon, preferably in a solvent such as methanol or ethanol at a temperature of approximately the reflux temperature. This reaction is particularly suitable for the preparation of compounds of formula 2 wherein Z ¹ is O and A ¹ is an ethylene group.

1 1

Compounds of formula 2 wherein R, A and Z have the same meanings as defined above, R ^{H +} * is an alkyl group, R represents a protecting group (e.g. benzyl or tert-butyloxycarbonyl) and L ¹ is alkenylene, an alkynylene group or a cycloalkenylene group in which a carbon-carbon multiple bond is attached directly to the phenyl portion of a compound of Formula 2 can be prepared by reacting a compound of Formula 3:

(3)

250 φ *

9 4

Φ Φ »

Φ · Φ ·

Φ ·

ΦΦ Φ

In which R, R, A and Z are as hereinbefore defined, and X ³ is an iodine atom, or preferably bromine, with a compound of formula X wherein R ³ and R ⁹ are as defined above from above, using standard Heck reaction conditions, for example, reactions carried out in the presence of palladium acetate, triphenylphosphine and tributylamine, at a temperature of up to about 120 ° C.

WITH

Compounds of formula 3 wherein R and X are as defined above, R is a protecting group (such as a benzyl group), A 1 is an optionally substituted straight chain alkylene group having 2 to 3 carbon atoms, and A is NH , may be prepared by reductive cyclization of a compound of Formula 4:

In which R, R, A and X are immediately as defined above. This reaction can be conveniently carried out using stannous chloride in the presence of hydrochloric acid at a temperature of up to about 80 ° C. This reaction is particularly suitable for the preparation of compounds of formula 3 wherein A ^x is an ethylene group, R is a benzyl group and A is NH.

C

Compounds of formula 4 in which R and X have the same meaning as previously defined, A - * - represents an optionally substituted alkylene group containing from 2 to 3

251 straight-chain carbon atoms and R is a protecting group (such as a benzyl group) can be prepared by reacting a compound of formula 5:

Wherein R, R, A and X are as hereinbefore defined with alkylsulfonyl chloride (or arylsulfonyl chloride) in the presence of a tertiary base such as triethylamine, followed by reaction with sodium iodide in acetone at reflux temperature .

Compounds of formula VIII wherein R, R,

R ⁴ 6 and L ⁴ have the same meaning as previously defined and A ⁴ represents an optionally substituted straight-chain alkylene group having 2 to 3 carbon atoms, similarly prepared from a compound of formula 6:

wherein R ⁴ , R ⁴ , R ⁴ , A ⁴ and L ⁴ are immediately as defined above.

• ·

252 • · ► and φφ

5

Compounds of formula 5 wherein R and X have:

9β as defined above, R represents a suitable protecting group, such as a benzyl group and A ¹ represents an optionally substituted straight chain alkylene group having 2 to 3 carbon atoms, may be prepared by reacting a compound of formula 7:

Wherein R and X are as defined immediately above, with a compound of Formula 8:

R ²⁰ -NH-A ¹ -OH (8) wherein R and A have the same meaning as defined immediately above, in an inert solvent such as n-butanol, and at a temperature up to reflux.

Compounds of formula 6, wherein R ^1, R ^z, R ^{± a} and L ¹ have the same meanings as defined above and A ¹ represents an optionally substituted alkylene group having 2-3 carbon atoms, straight chain, can be similarly prepared from compounds of formula 9:

i? -co ₂ y ¹⁶

Italy (9)

253 • · in which R ^2, R ¹ _and L have the same meanings as defined above.

5

Compounds of formula (3) in which R and X have the same meaning as defined immediately above, R represents a suitable protecting group (such as an acetyl group), A ¹ represents an optionally substituted straight chain alkylene group having 2 to 3 carbon atoms and Means O, may be prepared by reacting a compound of formula 10:

wherein R 1, R ^2, Q, A 4 and X 8 are as defined immediately above, with the compound of Formula 11:

Br-A 1 Br (11) wherein A 1 is as defined immediately above, in the presence of a base such as sodium hydroxide and aliquat in an inert solvent such as dichloromethane and at a temperature approximately equal to room temperature . This reaction is particularly suitable for the preparation of compounds of formula 3 wherein A ¹ is an ethylene group.

O 1 1 A

Compounds of formula (2) in which R, A ^-1 and R 6

254 have the same meaning as previously defined and ΐΛ represents an alkylene group substituted with -CHO ² (such as -CH ₂ OCH ₂ ) can be prepared from compounds 21A of formula 2 wherein R and R ⁰ are as defined above has been defined above and 1A represents an alkenylene group in which the carbon-carbon double bond is substituted by a methyl group, using the following standard reaction method:

(i) carrying out allyl bromination with N-bromosuccinimide; (ii) replacing allyl bromine with an OR ^ ^{2 * 4 group} by reaction with an alkali metal salt of the formula

R ¹⁴ O-M ⁺ (such as sodium methoxide), (iii) hydrogenating.

1 A 1

Compounds of formula (III) wherein R, R ¹⁰ , A

-É "| and having the same meaning as previously defined and L being an optionally substituted arylene or optionally substituted heteroaryldiyl group, may be prepared by reacting a compound of formula 3 wherein R, A and Z are as defined above and X 8 is iodine or bromine, with a compound of formula 12:

Br-L ¹ -CO ₂ R ¹⁶ (12) wherein R 6 has the same meaning as previously defined and when it is an optionally substituted arylene group or an optionally substituted heteroaryldiyl group, in the presence of a complex metal catalyst such as

- 255 -

for example tetrakis (triphenylphosphine) palladium, and using standard reaction conditions such as those disclosed in Trecourt et al. Tetrahedron, (1995), 43, pp. 11743-11750.

1

Compounds of formula (IX) in which R, R, A and

X ⁴ have the same meaning as previously defined and Z ¹ is NR ⁹ , NC (= O) -R ⁹ ,

NC (= O) -OR ¹⁴ or NSO ₂ R ¹⁴ may be prepared from compounds of formula 12 wherein R, R, A and X are as defined above and Z ¹ is NH by standard alkylation, by an acylation (or peptide coupling) or sulfonylation procedure, such as described above.

1 5

Compounds of formula 3 wherein R, A and X 2Ω are as defined above, R is a protecting group (such as benzyl) and Z ¹ is NR ⁹ , NC (= O) -R ⁹ , NC (= O) -OR ¹⁴ or NSO ₂ R ⁹ may be prepared from compounds of the formula wherein R ² , A ¹ and X ³ have the same meaning as previously defined,

R is a protecting group (such as a benzyl group) and Z ¹ is NH.

Compounds of formula (III) or (2) wherein R ¹ and R ¹ are as defined above and L ¹ is -CH ₂ -CH-

I nh ₂ can be prepared by standard methods used for the preparation of α-amino acids, for example, those described in Organic Syntheses Based On Name Reactions and. · · ·

256 ··· 9

9

Unnamed Reactions, A. Hassner and C. Stumer, Pergamon, pp. 275-374.

O 1 A 1

Compounds of formula 2 wherein R, R, A and Z · · * have the same meanings as defined above, and ΐΛ represents -CH ₂ -CH-

I nh ₂ can be prepared by reacting compounds of formula 13:

ch ₂ -x (13) in which:

1 1

R, A and Z have the same meaning as previously defined, and χ 16 represents a bromine or chlorine atom, with the anion derived from the reaction of (2R) - (-) - 2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine with butyllithium using the method described in DL Boger and D. Yohannes, J. Org. Chem. [JOCEAH], 1990, 55, used to prepare compounds of Formula 31 on page 6010.

1 A 1

Compounds of formula (2) in which R, R ^{+ D} and A have the same meaning as previously defined and β represents a group

257 CH-CH ₂ -

AND

CH ₂ CO ₂ Me can be prepared by reacting compounds of formula 2 wherein R 1, R 2 and have the same meaning as previously defined and L ¹ is -CH = CH- with dimethylmalonate in the presence of an alkali metal alkoxide such as sodium methoxide, in methanol and at a temperature approximately equal to the reflux temperature.

1

Compounds of formula (I) wherein R, R and A have the same meaning as previously defined and the moiety IA-Y is

This can be prepared by coupling compounds of formula 8 wherein R and A are as defined above and represents a halogen atom, preferably bromine or iodine, with 5,6-dihydropyran-2-one in the presence of tetrakis (triphenylphosphine) palladium and triethylamine in an inert solvent such as dimethylformamide at a temperature of about 95 ° C and in a sealed container.

The intermediates of formula (III), (VIII), (IX), (5) and (8) are novel compounds and therefore compounds falling within the scope of the patent protection of the present invention as well as processes for their preparation.

258

DETAILED DESCRIPTION OF THE INVENTION

The compounds of the present invention, processes for their preparation, and other aspects will be explained in more detail below with the aid of examples, which are, however, illustrative only and not limiting.

The 400MHz ⁴ H (NMR) nuclear magnetic resonance spectra were recorded on a Bruker 400DMX instrument. The 300MHz ⁴ H (NMR) nuclear magnetic resonance spectra were recorded on a Bruker 300AC or Bruker 300 DPX instrument.

For these nuclear magnetic resonance spectra (NMR), chemical shifts (δ) were expressed in ppm relative to tetramethylsilane. Use of the abbreviation has the following meaning:

s = singlet, d = doublet, t = triplet, m = multiplet, q = quartet, dd = doublet of doublets, ddd = doublet of doublets of doublets.

MS (CI) desorption chemical ionization mass spectra were recorded on a Finnigan SSQ 7000 spectrometer using ammonia as the reaction gas.

Liquid secondary ion mass spectra, MS (LSIMS), were recorded on a VG AutoSpec spectrometer using glycerol-thioglycerol 50/50 as a matrix. Electrospray mass spectra, MS (ES), were recorded on a Micromass Platform II spectrometer.

259

Example 1 (a) 3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydroquinoxalin-6-yl acid ) -propionic

A solution containing 3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxaline acid ester was used. -6-yl) -propanoic acid (0.16 g, Reference Example 1) in anhydrous ethanol (3 mL) which was treated at 25 ° C by adding a solution of lithium hydroxide monohydrate (22 mg) in distilled water (1 mL) The addition was carried out dropwise. After stirring for 4 hours at 25 ° C, an additional portion of lithium hydroxide monohydrate (10 milligrams) was added, followed by stirring for 16 hours at 25 ° C. The reaction mixture was concentrated under reduced pressure (2.7 kPa) at 40 ° C and the residue was treated with distilled water (40 ml). The resulting solution was washed twice with diethyl ether (20 ml), acidified to pH 3 by addition of hydrochloric acid (1.3 ml, 1N solution) and then extracted three times with ethyl acetate (25 ml). The combined organic extracts were washed twice with water (5 mL), dried over magnesium sulfate and then evaporated under reduced pressure (2.7 kPa) at 40 ° C to give the title compound as a foamed solid.

Yield: 132 mg.

¹ H NMR [400 MHz, (CD ₃ ) ₂ SO]: δ

2.2 (s, 3H), 2.5 (bq, 2H), 2.7 (bp, 2H),

3.2 (s band, 2H), 3.65 (s band, 2H), 3.8 (s, 5H), •

- 260

6.1 (s band, 1H), 6.4 (s band, 1H), 6.45 (s band, 1H),

6.7 (s band, 1H), 6.9 (t, J = 8Hz, 1H), 7.15 (m, 3H),

7.8 (d, J = 8 Hz, 1 H), 8 (s band, 1 H), 8.45 (s, 1 H),

8.6 (s, 1H); 12.1 (s band, 1H).

MS (LSIMS: glycerol + thioglycerol): 503 (MH ^&lt; ^{+ &gt;} ).

(b)

In this case, a procedure similar to that described in Example 1 (a) above was followed except that 3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) phenyl] ethyl ester was used) acetyl} -1,2,3,4-tetrahydroquinoxalin-6-yl) butyric (Reference Example 17), the crude product was subjected to preparative thin layer chromatography on silica (20 x 20 centimeter plates, 0.25 thickness) eluting with ethyl acetate, and 3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1-acid) was prepared as described above. 2,3,4-tetrahydro-quinoxalin-6-yl) -butyric acid as a white powder.

¹ H NMR [400 MHz, (CD 3 SO 4, at room temperature, mixture)

rotamers]: δ 1.18 (d, J = 7Hz, 3H) , 2.26 (s, 3H) 2.43 (m, 2H). 3.00 (wide band, 1H), 3.20 (wide band, 2H), 3.67 (m, 2H), 3.83 (wide band, 2H), 3.83 (s, 3H) 6.00 - 7.60 (m, 9H); 7.80 (d, J = 8 Hz, 1H) , 8.01 (wide band, 1H), 8.48 (belt with, 1H), 8.58 (passport s, 1H). MS (EI): 516 (M ⁺ ). (C)

In this case, a procedure similar to that described in Example 1 (a) above was used except that 3- (4-acetyl-1 - {[3-methoxy-

261

··

-4- (3-o-tolylureido) -phenyl] -acetyl} -1,2,3,4-tetrahydroquinoxalin-6-yl) -propanoic acid (Reference Example 16 (b)), the crude product was subjected to preparative chromatography thin layer on silica (20 x 20 centimeter plates, 0.25 mm thick) eluting with dichloromethane / methanol (9: 1 by volume) to give the acid as described above

3- (4-Acetyl-1 - {[3-methoxy-4- (3-o-tolylureido) -phenyl] acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propionic acid in the form of white foam followed by trituration of the compound with diisopropyl ether.

1 H NMR [300 MHz, (CD 3) ₂ SO at room temperature, mixture of rotamers]: δ

2.01 (broad band, 3H), 2.26 (s, 3H),

2.56 (t band, J = 7.5 Hz, 2H), 2.83 (t band, J = 7.5 Hz, 2H), 3.70-3.95 (m, 9H), 6.45 - 6,85 (very broad band, 2H),

6.95 (t band, J = 7.5 Hz, 1H), 7.05-7.25 (m, 3H),

7.20 - 7.70 (very wide band, 2H),

7.80 (band d, J = 8Hz, 1H),

7.96 (very broad band d, J = 8 Hz, 1H),

8.47 (s band, 1H), 8.55 (s band, 1H).

MS (CI): 545 (MH ^&lt; ^{+ &gt;} ).

(d)

In this case, a procedure similar to that described in Example 1 (a) above was followed except that 3- (4-benzoyl-1 - {[3-methoxy-4- (3-o-tolyl) ethyl ester was used. (ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydroquinoxalin-6-yl) -propanoic acid (Reference Example 16 (c)), followed by trituration of the reaction product with diisopropyl ether to prepare desired product, acid • · · • ·

262 • ♦ ··

3- (4-Benzoyl-1 - {[3-methoxy-4- (3-o-tolylureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propionic acid in the form of a white powder.

1 H NMR [400 MHz, (CD ₃ ) ₂ SO, at 373 ° K]: δ

2.19 (t band, J = 7.5 Hz, 2H), 2.27 (s, 3H),

2.58 (t band, J = 7.5 Hz, 2H), 3.83 (s, 3H), 3.92 (m, 2H),

3.95 (s, 2H), 4.00 (m, 2H), 6.65 (s band, 1H),

6.76 (dd, J = 8 and 1.5 Hz, IH), 6.88 (d, J = 1.5 Hz, IH),

6.95-7.05 (m, 2H), 7.15-7.25 (m, 4H),

7.34 (t band, J = 7.5 Hz, 2H), 7.42 (t band, J = 7.5 Hz, 1H),

7.56 (d, J = 8Hz, IH), 7.77 (band d, J = 8Hz, IH),

8.02 (d, J = 8 Hz, 1H), 8.21 (s band, 1H), 8.27 (s band, 1H).

MS, LSIMS 607 (MH ^&lt; ^{+ &gt;} ).

(E)

In this case, a procedure similar to that described in Example 1 (a) above was followed, except that 4- (7- (2-ethoxycarbonyl-ethyl) -4 - {[3-methoxy-4-] ethyl ester was used. (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-quinoxalin-1-yl) -4-oxo-butane [Reference Example 16 (d)], wherein the product thus obtained is subjected to Reversed phase HPLC (RP-C18 Uptisphere 3μ column, Part # UP3ODB / 10M Interchim, Montlucon, France, 10x100mm, milliliters / minute, acetonitrile: water 80:20 by volume) , eluted! for 5 minutes then up to a volume ratio of 50:50 over 3 minutes and then a steady state for 30 minutes, wavelength 254 nm] to produce the desired acid product

4- (7- (2-carboxyethyl) -4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-quinoxalin-1-yl 4-Oxo-butyric acid in the form of a white foam.

263

HPLC: R _T = 24.07 minutes.

(F)

A procedure similar to that described in Example 1 (a) above was followed except that 3- (4- (3-dimethylamino-propionyl) -1 - {[3-methoxy-4-] ethyl ester was used. (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propanoic acid (Reference Example 21) and the crude product obtained was subjected to preparative thin-layer chromatography. Silica layer (20 x 20 centimeters, 1 mm thick), eluting with dichloromethane: methanol (9: 1 by volume) to give the desired 3- (4- ( 3-Dimethylamino-propionyl) -1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propionic acid in the form of white foam.

¹ H NMR [400 MHz, (CD ₃ ) ₂ SO at 373 ° K]: δ

2.19 (with, 6H) , 2.28 (s, 3H), 2.50 - 2,60 (m, 4H) 2.65 (passport t, J = 6.5Hz, 2H) , 2.9 0 (t, J = 7.5 Hz, 2H) 3.80 - 3, 90 (m, 7H) 3 , 91 (m , 2H) , 6.69 (passport d, J = 8Hz, 1H), 6.81 (belt with, 1H), 6.98 (passport t, J = 7.5Hz, 1H) , 7.1 0 - 7.2 0 (m, 3 H), 7.40 (passport with, 1H), 7.56 (d, J = 8 Hz, 1H) 7.68 (passport d, J = 8Hz, 1H), 7.98 (d, J = 8.5 Hz, 1H) 8.22 (širi oký band, 1H), 8.29 (passport s, 1H). MS: LSIMS 60 2 (MH ^&lt; ^{+ &gt;} ). (G)

In this case, a procedure similar to that described in Example 1 (a) above was used except that 7- (2-ethoxycarbonyl-264-ethyl) -4 - {[3-methoxy-4-tert-butyl ester] was used. - (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-quinoxaline-1-carboxylic acid (Reference Example 2) to give the desired product, 7- (tert-butyl ester) ( 2-carboxy-ethyl) -4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-quinoxaline-1-carboxylic acid as a white solid substances.

Y NMR [400 MHz, (CD ₃ ) ₂ SO, at room temperature, mixture of rotamers]: δ

1.48 (s, 9H), 2.26 (s, 3H), 2.55 (m, 2H),

2.83 (t band, J = 7.5 Hz, 2H), 3.63 (m, 2H),

3.75 - 3.90 (m, 7H), 6.55 - 6.85 (very broad band, 2H),

6.90-7.05 (m, 2H), 7.10-7.25 (m, 2H),

7.45 (broad band, 1H), 7.63 (broad band, 1H),

7.78 (d, J = 8Hz, 1H), 8.03 (band d, J = 8Hz, 1H),

8.50 (s, 1H), 8.56 (s band, 1H),

II, 80-12.60 (very broad band, 1H).

MS (DCI): 620 (MNH ₄ ⁺⁾ 603 (MH ^+).

Example 2 (a) (R, S) -3- (4 - {[3-Methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzoic acid [1,4] oxazin-7-yl) -5-methylhexane.

A solution containing 3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-ethyl ester (R, S) -ethyl ester was used. -benzo [1,4] oxazin-7-yl) -5-methylhexanoic acid [95 milligrams, Reference Example 10 (a)] in methanol (20 ml) which was treated with aqueous lithium hydroxide solution (2 ml, 2M solution). After stirring at room temperature for 16 hours, the mixture was heated at 50 ° C for 16 hours

265

The mixture was concentrated to a small volume and then treated with water. The resulting solution was acidified to pH 1 by addition of aqueous hydrochloric acid (1M solution). The precipitate was collected, aspirated to dryness and then the product was dried in a desiccator at 60 ° C to give the title compound.

Yield: 85 mg.

LC-MS: R _T = 3.74 minutes (89% ELSD);

MS (ES ^&lt; ^{+ &gt;} ) 559 (MH ^&lt; ^{+ &gt;} ).

(b)

In this case, the procedure was as in Example 2, except that 3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -) - (R, S) ethyl ester was used - phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-phenylpropanoic acid [Reference Example 10 (c)], to give the desired product, acid (R, S) -3- (4 - {[3-Methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazine -7-yl) -3-phenylpropanoic acid as an off-white solid.

LC-MS: R _T = 3.59 minutes (99% by ELSD);

MS (ES ⁺ ) 580 (MH &lt; ⁺ &gt;), 602 (MNa &lt; ⁺ & gt ^; ).

(C)

The procedure was similar to Example 2 except that 3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -) - (R, S) ethyl ester was used - phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-o-tolylpropanoic acid [Reference Example 10 (d)], and using the above procedure, the desired (R, S) -3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,2-d] 4] oxazin-7-yl) -3-o-tolylpropanoic acid as a white solid.

266 ·· Φ Φ φ φ φ φ φ φ φ φ φ φ Φ Φ Φ Φ Φ Φ Φ · φ · · · · ·

LC-MS: R y = 3.67 minutes (100% ELSD);

MS (ES ⁺ ) 594 (MH &lt; ⁺ &gt;), 616 (MNa &lt; ⁺ & gt ^; ).

(d)

The procedure was similar to Example 2 except that 3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -) - (R, S) ethyl ester was used - phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -butanoic acid [Reference Example 10 (e)], and the desired product (R, S) -3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazine-7 -yl) butane as an off-white solid.

LC-MS: R y = 3.36 minutes (95% ELSD);

MS (ES ⁺ ) 518 (MH &lt; ⁺ &gt;), 540 (MNa &lt; ⁺ & gt ^; ).

Example 3 (a) (R, S) -3- (4 - {[3-Methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzoic acid [1,4] oxazin-7-yl) -4-methylpentanoate

A solution comprising 3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzoic acid (R, S) ethyl ester was used [1,4] oxazin-7-yl) -4-methylpentanoic acid [Reference Example 10 (b)] in methanol (20 ml) which was treated with aqueous sodium hydroxide solution (3 ml,

M solution). The reaction mixture was heated at 50 ° C for 1 hour, allowed to stand at room temperature for 16 hours and then evaporated to a small volume and finally treated with water (20 ml).

The resulting solution was acidified to pH 1 by the addition of * · ·· φ

Aqueous hydrochloric acid solution (1 M solution) and the resulting precipitate was collected, suction dried and then dried in a desiccator at 60 ° C to give the title compound. as a white solid.

Yield: 80 mg.

LC-MS: R _T = 3.62 minutes (100% ELSD);

MS (ES ⁺ ) 546 (MH &lt; ⁺ &gt;) 568 (MNa &lt; ⁺ & gt ^; ).

(b)

In this case, the procedure was as in Example 2, except that 3- {4- [3- (2-o-tolyl-benzoxazol-6-yl) -propionyl] ethyl ester was used. -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -butanoic acid [Reference Example 10 (f)], to give the desired product, acid

3- {4- [3- (2-o-Tolylamino-benzoxazol-6-yl) -propionyl] 3,4-dihydro-2H-benzo [1,4] oxazin-7-yl} -butanoate.

LC-MS: R _T = 3.43 minutes (100% ELSD);

MS (ES ^&lt; ^{+ &gt;} ) 500 (MH ^&lt; ^{+ &gt;} ).

Example 4

3- (4-Benzoyl-1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -buttery

A stirred solution containing 3- (4-benzoyl-1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydroquinoxaline ethyl ester was used. -6-yl) -butane [in an amount of 0.124 g,

Reference Example 16 (a)] in methanol (5 mL) was treated with sodium hydroxide solution (764 gI, 15%). The resulting reaction mixture was then heated at reflux for 30 minutes,

φ φ φ

268 φ · φφφ was then cooled to 40 ° C and then evaporated (40 mbar which is 4000 Pa, 40 ° C). The residue was treated with distilled water (40 ml) and the aqueous solution was washed three times with ether (20 ml), treated with hydrochloric acid (4 ml, 1 M solution) and extracted three times with ethyl acetate ( 25 ml). The combined extracts were dried over magnesium sulphate and evaporated to dryness (40 mbar, 4000 Pa, 40 ° C). The crude residue (91 mg) was subjected to preparative thin layer chromatography on silica (20 x 20 centimeter plates, 0.25 mm thickness), eluting with dichloromethane / methanol (9: 1 v / v): 1) to give the title compound as a white powder.

Yield: 15 mg.

1 H NMR [400 MHz, (CD ₂ ) ₂ SO, at 373 ° K]: δ

0.92 (d, J = 7Hz, 3H), 2.16 (d, J = 7.5Hz, 2Η),

2.27 (s, 3H), 2.80-3.05 (m, 1H), 3.84 (s, 3H),

3.94 (m, 2H), 3.96 (s, 2H), 4.01 (m, 2H), 6.60 (s band, 1H),

6.76 (band d, J = 8 Hz, 1H), 6.88 (band s, IH),

6.95-7.05 (m, 2H), 7.10-7.20 (m, 4H),

7.33 (t band, J = 7.5 Hz, 2H), 7.40 (t band, J = 7.5 Hz, 1H),

7.56 (d, J = 8Hz, IH), 7.68 (band d, J = 8Hz, IH),

8.04 (d, J = 8.5 Hz, 1H), 8.23 (s band, 1H),

8.29 (band s, 1H).

MS (ES): 621 (MH ^&lt; ^{+ &gt;} ).

Reference Example 1

3- (1 - {[3-Methoxy-4- (3-o-tolyl-ureido) -ethyl] -

• ·

269 phenyl] acetyl} -1,2,3,4-tetrahydroquinoxalin-6-yl) propanoic acid.

A solution containing 7- (2-ethoxycarbonyl-ethyl) -4 - {[3-methoxy-4- (3-o-tolylureido) -phenyl] -acetyl} -3-tert-butyl ester was used. 4-dihydro-2H-quinoxaline-1-carboxylic acid (0.3 g, Reference Example 2) in dichloromethane (3 mL) was treated with trifluoroacetic acid (0.5 mL) at 0 ° C which was added dropwise. After stirring for 2 hours at 0 ° C, an additional portion of trifluoroacetic acid (0.5 mL) was added, and the reaction mixture was stirred at 10 ° C for an additional hour. The reaction mixture was poured onto crushed ice (50 mL), adjusted to pH 8 by addition of sodium hydroxide (20 mL, 1 N solution) dropwise and extracted. twice with dichloromethane (25 ml). The combined organic extracts were washed twice with water (5 ml) and dried over magnesium sulphate, then evaporated under reduced pressure (2.7 kPa) at 40 ° C. The resulting white foam solid (235 mg) was flash chromatographed on silica (0.040-0.063 mm), eluting with dichloromethane: methanol (99: 1, v / v). the title compound was obtained as a white foam solid.

Yield: 170 mg.

¹ H NMR, 300 MHz, (CD ₃ ) ₂ SO: δ

270

1.2 (t, 3H), 2.3 (s, 3H), 2.6 (t, 2H), 2.8 (t, 2H),

3.25 (m, 2H), 3.7 (s, 2H), 3.85 (s, 2H), 3.9 (s, 3H),

4.1 (q, 2H), 5.8 (band s, 1H), 6.4 (dd, J = 8 Hz and 1.5 Hz, 1H), 6.5 (d, J = 1.5 Hz) 1 H, 6.7 (dd, J = 8 Hz and 1.5 Hz, 1 H), 6.85 (d, J = 1.5 Hz, 1 H), 7 (ddd, J = 8.8 and 1) , 5 Hz,

1 H), 7.2 (m, 3 H), 7.7 (band d, J = 8 Hz, 1 H), (d, J = 8 Hz, 1 H), 8.25 (s, 1 H), 8.35 (s, 1H).

MS (Cl, NH _3): MNH ₄ ⁺ 548, MH ⁺ 531st

Reference Example 2

7- (2-ethoxycarbonyl-ethyl) -4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-quinoxaline-1-tert-butyl ester carboxyl.

A solution containing 3-methoxy-4- [3-o-tolyl-ureido] phenylacetic acid (0.282 g, prepared as described in Example 52B in WO 96/22966) was used. Anhydrous tetrahydrofuran (5 mL) which was treated under argon at 25 ° C by the addition of a powdered molecular sieve 4A (0.5 grams), 7- (2-ethoxycarbonylethyl) -1,2,3,4 -tetrahydro-quinoxaline-1-carboxylic acid (0.2 grams, Reference Example 3), triethylamine,

O- (7-azabenzotriazol-1-yl) -Ν, Ν, Ν ', N'-tetramethyluronium hexafluorophosphonate (0.273 g and 4-dimethylaminopyridine (7 mg)) After stirring the reaction mixture at 25 ° The reaction mixture was filtered through a pad of celite for 3 hours and the filter pad was washed three times with ethyl acetate (10 ml) and the combined filtrate and washings were washed twice with an aqueous saturated solution.

271

ammonium chloride (20 ml), then water (20 ml), dried over magnesium sulphate and then evaporated under reduced pressure (2.7 kPa) at 40 ° C. The resulting white foam solid (0.783 g) was flash chromatographed on silica (0.040-0.063 mm) using cyclohexane / ethyl acetate (1: 1 v / v) as the eluent. The title compound was obtained as a white foamed solid.

¹ H NMR, 400 MHz, (CD ₃ ) ₂ SO: δ

1.2 (t, 3H), 1.5 (s, 9H), 2.3 (s, 3H), 2.65 (t, 2H),

2.9 (ΐ, 2H), 3.65 (ΐ, 2H), 3.85 (m, 7H), 4.1 (q, 2H),

6.7 (broad s, 2H), 7 (m, 2H), 7.2 (m, 2H),

7.5 (broad s, 1H), 7.65 (s, 1H),

7.8 (d, J = 8Hz, 1H), 8.05 (band d, J = 8Hz, 1H),

8.5 (s, 1H); 8.6 (s band, 1H).

MS (Cl, NH _3): MNH ₄ ⁺ 648, MH ⁺ 631st

Reference Example 3

7- (2-ethoxycarbonyl-ethyl) -1,2,3,4-tetrahydro-quinoxaline-1-carboxylic acid tert-butyl ester.

A stirred mixture containing 4-benzyl-7- (2-ethoxycarbonyl-vinyl) -1,2,3,4-tetrahydro-quinoxaline-1-carboxylic acid tert-butyl ester (1.83 g, Reference Example 4) was used. ), acetic acid (2 milliliters), methanol (40 milliliters) and 20% palladium dihydroxide on carbon powder (0.49 grams), the hydrogenation was carried out in a 250 milliliters stainless steel pressure reactor at 30 bar (3 MPa) ) hydrogen. After stirring this reaction mixture,

272 which was carried out for 20 hours at a temperature of 25 ° C, was obtained The reaction mixture was filtered through a pad of Celite and the filter pad was washed with dichloromethane (25 mL) and then with methanol (25 mL). The filtrate and washings were combined and evaporated under reduced pressure (2.7 kPa) at 40 ° C. The resulting brown oil (1.99 g) was flash chromatographed on silica (0.0400-0.063 mm) using initially a cyclohexane / ethyl acetate (9: 1 by volume) mixture as the eluent, and then cyclohexane / ethyl acetate (7: 3, v / v) to give the title compound as a yellow oil.

Yield: 0.856 g.

¹ H NMR, 300 MHz, (CD ₃ ) ₂ SO: δ

1.2 (t, 3H), 1.5 (s, 9H), 2.5 (t, 2H), 2.7 (ΐ, 2H),

3.25 (m, 2H), 3.6 (bp, 2H), 4.1 (q, 2H), (s, 1H), 6.5 (d, J = 8 Hz, 1H),

6.7 (dd, J = 8 Hz and 1.5 Hz, 1H), 7.2 (band s, 1H).

MS (EI): M @ ⁺ 334 (40%), 278 (20%), 234 (100%), 189 (10%), 159 (10%), 147 (40%), 57 (40%).

Reference Example 4 (a) 4-Benzyl-7- (2-ethoxycarbonyl-vinyl) -1,2,3,4-tetrahydro-quinoxaline-1-carboxylic acid tert-butyl ester

A mixture containing 4-benzyl-7-bromo-1,2,3,4-tetrahydroquinoxaline-1-carboxylic acid tert-butyl ester (2.4 g, Reference Example 5), tri- o-tolylphosphine (96 milligrams), palladium acetate (24 milligrams)

273 and ethyl acrylate (1.3 milliliters) in tributylamine (20 milliliters); the solution was heated to 110 ° C. After stirring for 2 hours at 110 ° C, the reaction mixture was treated with additional portions of ethyl acrylate (1.3 ml), tri-o-tolylphosphine (96 mg) and palladium acetate (24 mg) with stirring. The reaction mixture was carried out for a further 16 hours at 110 ° C. The reaction mixture was cooled to room temperature and then acidified to pH 2 by the addition of hydrochloric acid (50 mL, 1 N solution) and extracted three times with ethyl acetate (50 mL). The combined organic extracts were washed with an aqueous saturated sodium bicarbonate solution (20 mL), then three times with water (20 mL), dried over magnesium sulfate and then evaporated under reduced pressure (2.7 kPa) at 40 ° C. Deň: 32 ° C. The resulting brown oil (5 grams) was flash chromatographed on silica (0.040-0.063 mm), eluting with cyclohexane / ethyl acetate (9: 1, v / v). prepared the title compound as a yellow oil.

Yield: 1.83 g.

¹ H NMR, 400 MHz, (CD ₃ ) ₂ SO: δ

1.3 (t, 3H), 1.5 (s, 9Η), 3, 5 (strip t, 2H) 3.8 (passport t, 2Η), 4.15 (q, 2H); 4.65 (s, 2H); 6.25 (d , J = 16 Hz, 1H) »» 6.65 (d, J = 8Hz, 1Η), 7.3 ( m, 4H), 7.4 (t, 2H) > 7.5 (d, J = 16Hz, 1H), 7.7 (belt with, 1H). MS ( EI): M ⁺ 422 (50%), 366; (60%) 322 (40 %) 277 (20 '%), 231 (40%), 185 (10%), 157 (15%) 91 (100 %) 57 (40 %).

- 274

(b)

A similar procedure to that described in Reference Example 4 (a) was used except that 4-tert-butyloxycarbonyl-7-bromo-3,4-dihydro-2H-benzo [1,4] oxazine was used. [Reference Example 5 (b)] and (E) -5-methylhex-2-enoic acid ethyl ester, the reaction was carried out in dimethylformamide at 140 ° C, to produce (E) - a ( Z) -3- (4-tert-Butyloxy-carbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -5-methylhex-2-ene.

Yield: 240 mg.

(C)

A similar procedure to that described in Reference Example 4 (a) was followed except that 4-tert-butyloxycarbonyl-7-bromo-3,4-dihydro-2H-benzo [1,4] oxazine was used. [Reference Example 5 (b)] and (E) -4-methylpent-2-enoic acid ethyl ester, the reaction was carried out in dimethylformamide at 140 ° C to produce (E) - a ( Z) -3- (4-tert-Butyloxy-carbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -4-methylpent-2-ene.

(d)

A similar procedure to that described in Reference Example 4 (a) was used except that 4-tert-butyloxycarbonyl-7-bromo-3,4-dihydro-2H-benzo [1,4] oxazine was used. [Reference Example 5 (b)] and ethyl cinnamate, the reaction was carried out in dimethylformamide at 140 ° C, and ethyl acetate (E) - 275 was prepared as described above.

and (Z) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-phenylprop-2-ene.

(E)

A similar procedure to that described in Reference Example 4 (a) was used except that 4-tert-butyloxycarbonyl-7-bromo-3,4-dihydro-2H-benzo [1,4] oxazine was used. [Reference Example 5 (b)] and (E) - 3- (2-methylphenyl) prop-2-enoic acid ethyl ester, the reaction was carried out in dimethylformamide at 140 ° C, and ethyl acetate ( E) - and (Z) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-3-o-tolylprop-2-ene ( F)

A similar procedure to that described in Reference Example 4 (a) was used except that 4-tert-butyloxycarbonyl-7-bromo-3,4-dihydro-2H-benzo [1,4] oxazine was used. [Reference Example 5 (b)] and ethyl crotonate, the reaction was carried out in dimethylformamide at 130 ° C, and the above-described ethyl ester of (E) and (Z) -3- (4-tert-butyloxycarbonyl) was prepared. -3,4-Dihydro-2H-benzo [1,4] oxazin-7-yl) -but-2-ene.

Reference Example 5 (a) 4-Benzyl-7-bromo-1,2,3,4-tetrahydroquinoxaline-1-carboxylic acid tert-butyl ester

A mixture containing 4-benzyl-7-bromo-1,2,3,4-tetrahydroquinoxaline (3.28 grams,

276

Reference Example 6), di-tert-butyl dicarbonate (2.71 g) and sodium bicarbonate (0.91 g) in anhydrous dichloromethane (20 mL) were stirred for 16 hours at 25 ° C. additional portions of di-tert-butyl dicarbonate (2.71 g) and sodium bicarbonate (0.91 g) were added and the reaction mixture was stirred at 25 ° C for 72 hours. The reaction mixture was treated with distilled water (50 mL) and the organic phase separated. The aqueous phase was extracted twice with dichloromethane (20 ml) and the combined organic phases were washed three times with water (20 ml), then dried over magnesium sulphate and then evaporated under reduced pressure (2.7 kPa) at 40 ° C. The residual solid (7.4 g) was recrystallized from diisopropyl ether to give the title compound as a reddish brown solid.

Yield : 3.5 grams. NMR, 400 MHz, (CD ₃ ) ₂ SO: δ 1.5 (s, 9H), 3.5 (t band, 2H), 3.8 (band ΐ, 2H), 4.6 (with, 2H), 6.6 (d, J = 8 Hz, 1 H), 7.0 (dd, J) = 8 Hz and J = 1.5 Hz, 1H), 7.2 (m, 3H), 7.4 (ΐ, 2H), 7.6 (passport s, 1H). MS (EI): M ⁺ 404 and 402 (20%) 348 and 346 (90%),

303 and 301 (15%), 257 and 255 (20%), 213 and 211 (20%), (100%), 57 (40%).

(b)

A similar procedure to that described in Reference Example 5 (a) was used, except that 7-bromo-3,4-dihydro-2H-benzo [1,4] oxazine was used (Reference Example). 12) and the reaction was carried out in the absence of sodium bicarbonate

277 - • ♦ · • · · · ·· · • · · · ·· • · · ·· · ·· ·· · · · • · ·

in tetrahydrofuran at 50 ° C to give 4-tert-butyloxycarbonyl-7-bromo-3,4-dihydro-2H-benzo [1,4] oxazine as a crystalline white solid.

Reference Example 6

4-Benzyl-7-bromo-1,2,3,4-tetrahydroquinoxaline.

A stirred mixture containing benzyl- (4-bromo-2-nitro-phenyl) - (2-iodoethyl) -amine (23.55 grams, Reference Example 7), stannous chloride dihydrate ( 41.48 g), hydrochloric acid (12.28 ml, 12 N solution) and distilled water (45 ml) were heated at 80 ° C for 1 hour, then cooled to room temperature and then was treated with distilled water (200 ml). The reaction mixture was neutralized to pH 7-8 by addition of 32% aqueous ammonia solution (50 mL), then filtered through a pad of celite, washed three times with dichloromethane (250 mL), and the filtrate and washings were combined. The organic phase was separated, washed four times with distilled water (200 ml), then the product was dried over magnesium sulphate and then evaporated under reduced pressure (2.7 kPa) at 40 ° C. The resulting brown oil (14.47 g was then subjected to flash chromatography on silica (0.040-0.063 mm), initially using a mixture of cyclohexane and ethyl acetate (9: 1 by volume) and then using a mixture of cyclohexane and ethyl acetate (7: 3 by volume) ) and in this manner the desired compound was prepared

278 • · · · t t t t 278 278 278 278 278 The title compound as a reddish brown solid.

Yield: 3.28 g.

¹ H NMR, 300 MHz, (CD ₃ ) ₂ SO: δ

3.1 (s, 4H), 4.2 (s, 2H), 5.6 (s, 1H),

6.1 (d, J = 8Hz, 1H), 6.2 (dd, J = 8Hz and J = 1.5Hz, 1H),

6.3 (d, J = 1.5 Hz, 1H), 7.25 (m, 5H).

MS (EI): M ⁺ 304 and 302 (100%), 213 and 211 (100%), 132 (85%), 91 (60%).

Reference Example 7

Benzyl- (4-bromo-2-nitro-phenyl) - (2-iodo-ethyl) -amine.

A reaction mixture containing methanesulfonic acid 2- [benzyl- (4-bromo-2-nitro-phenyl) -amino] -ethyl ester (25 g, Reference Example 8) and sodium iodide (16.23 g) was used. in anhydrous acetone (100 mL), refluxing for 4 hours, adding an additional portion of sodium iodide (8.12 grams) and refluxing for an additional 2 hours. 16 hours. The reaction mixture was concentrated under reduced pressure (2.7 kPa) at 40 ° C and the residue was treated with distilled water (200 mL). The resulting mixture was then extracted three times with dichloromethane (150 mL). The combined organic extracts were dried over magnesium sulphate and then evaporated under reduced pressure (2.7 kPa) at 40 ° C. The resulting brown oil (29.16 grams) was subjected to flash chromatography on silica (0.040-0.063 mm), eluting with cyclohexane: ethyl acetate (9: 1, v / v) as described above. ΦΦ · · · · · ·

279 The desired title compound was prepared as a yellow oil.

1 H-NMR, 300 MHz, (CD ₃ ) ₂ SO: δ

3.3 (m, 4H); 4.4 (s, 2H); 7.25 (m, 5H);

7.4 (d, J = 8Hz, 1H), 7.6 (dd, J = 8Hz and J = 1.5Hz, 1H), 8 (d, J = 1.5Hz, 1H).

MS (EI): M ⁺ 462 and 460 (5%), 445 and 443 (20%), 321 and 319 (10%), 91 (100%).

Reference Example 8

Methanesulfonic acid 2- [benzyl- (4-bromo-2-nitro-phenyl) -amino] -ethyl ester

A solution containing 2- [benzyl- (4-bromo-2-nitro-phenyl) -amino] -ethanol (19.52 grams, Reference Example 9) and triethylamine (7.8 mL) was used in this example. Anhydrous tetrahydrofuran (95 mL) was treated dropwise at 25 ° C by the addition of methanesulfonyl chloride (4.75 mL). After stirring for 4 hours at 25 ° C, an additional portion of methanesulfonyl chloride (4.75 ml) was added, followed by stirring the reaction mixture for a further 16 hours at 25 ° C. The reaction mixture was then treated with water (100 ml), the organic phase separated and the aqueous phase extracted three times with ethyl acetate (150 ml). The combined organic phases were washed with saturated aqueous sodium bicarbonate solution (50 ml), then three times with distilled water (50 ml), dried on magnesium sulfate and then concentrated under reduced pressure (2.7 kPa) at a pressure of 2.7 kPa. temperature of 40 ° C and above

280

The title compound was obtained as a brown oil.

Yield: 25.41 g.

1 H-NMR, 300 MHz, (CD ₃ ) ₂ SO: δ:

3.1 (s, 3H) , 3,4 (ΐ, 2H), 4.2 (ΐ, 2H), 4.4 (with, 2H) 7.2 (m, 5H) , 7.4 (d, J = 8Hz, 1H) 7.7 (dd, J = 8 Hz and J = 1.5 Hz, 1H), 8 (d, J = 1.5 Hz, IH) MS (EI): M @ ⁺ 430 a 428 (5%), 321 and 319 (20 %) 91 (100 %).

Reference Example 9

2- [Benzyl- (4-bromo-2-nitro-phenyl) -amino] -ethanol.

A mixture of 2,5-dibromonitrobenzene (40 grams) and N-benzylethanolamine (40.4 milliliters) in 1-butanol (160 milliliters) was heated at reflux. an additional portion of N-benzylethanolamine (20.2 mL) was added and refluxed for a further 1 hour. The reaction mixture was concentrated under reduced pressure (2.7 kPa) at 40 ° C and the residue was treated with water (500 mL) and extracted three times with diethyl ether (250 mL). The organic extracts were combined and washed with hydrochloric acid (180 ml,

N solution), then aqueous sodium bicarbonate (20 ml, 5%) and then twice with distilled water (50 ml), dried over magnesium sulphate and then evaporated under reduced pressure (2.7 kPa) at 40 ° C. C. The resulting brown oil (47.1 grams) was then subjected to flash chromatography on silica (0.040 to 50 mg).

281

0.063 mm) using dichloromethane as the eluent to give the title compound as a red oil. Yield: 19.66 g.

⁴ H-NMR, 400 MHz, (CD ₃ ) ₂ SO: δ:

3.1 (ΐ, 2H), 3.5 (q, 2H), 4.5 (s, 2H), 4.6 (t, 1H),

7.3 (m, 6H), 7.6 (dd, J = 8Hz and J = 1.5Hz, 1H), (d, J = 1.5Hz, 1H).

MS (EI): M ⁺ 352 and 350 (5%), 321 and 319 (20%), 91 (100%).

Reference Example 10 (a) (R, S) ethyl 3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H- benzo [1,4] oxazin-7-yl) -5-methylhexanoic acid.

A solution containing (R, S) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -5-methylhexanoic acid ethyl ester was used [ 90 mg, Reference Example 11 (a)] in dichloromethane (5 ml) which was treated with trifluoroacetic acid (2 ml). After stirring for 30 minutes, the reaction mixture was evaporated to dryness. The residue was dissolved in dimethylformamide (10 ml) and treated with diisopropylethylamine (96 mg) followed by [3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetic acid (80 mg) and then O- (7-azabenzotriazol-1-yl) 1,1,3,3-tetramethyluronium hexafluorophosphate (96 mg). The reaction mixture was stirred at room temperature for 16 hours, then partitioned between ethyl acetate (50 mL) and aqueous hydrochloric acid (50 mL, 1 M solution). The organic phase was then washed with 5% aqueous bicarbonate solution

282 ml of sodium (50 ml) was dried on magnesium sulfate and then evaporated. The residue was flash chromatographed on silica eluting with ethyl acetate / cyclohexane (1: 1, v / v) to give the title compound as a colorless oil.

Yield: 95 mg.

(b)

In a manner similar to that described in Reference Example 10 (a), except that (R, S) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1, 4] oxazin-7-yl) -4-methylpentanoic acid [Reference Example 11 (b)] 3- (4 - {[3-methoxy-4 (3-o-tolyl) (R, S) ethyl ester) was prepared according to this procedure (ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -4-methylpentanoic acid as a cream foam.

(C)

In a manner similar to that described in Reference Example 10 (a), except that (R, S) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1, 4] oxazin-7-yl) -3-phenylpropanoic acid [Reference Example 11 (c)], 3- (4 - {[3-methoxy-4- (3-o) ethyl ester (R, S) ethyl ester was prepared according to this procedure -tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-phenylpropanoic acid as a white solid.

(d)

In a similar way as in Reference

283

of Example 10 (a), except that (R, S) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) ethyl ester is used ) -3-o-tolylpropanoic acid [Reference Example 11 (d)], 3- (4 - {[3-methoxy-4- (3-o-tolyl-ureido)) (R, S) ethyl ester was prepared according to this procedure -phenyl] -acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-o-tolylpropanoic acid as a white solid.

(E)

In a manner similar to that described in Reference Example 10 (a), except that (R, S) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1, 4] oxazin-7-yl) -butanoic acid [Reference Example 11 (e)] 3- (4 - {[3-methoxy-4- (3-o-tolyl-) - (R, S) ethyl ester) was prepared according to this procedure ureido) phenyl] acetyl} -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) butanoic acid as a colorless oil.

(F)

In a similar manner to that described in Reference Example 10 (a), except that (R, S) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1,2-a] ethyl ester was used. 4] oxazin-7-yl) -butanoic acid [Reference Example 11 (e)], 3- {4- [3- (2-o-tolylamino-benzooxazole-6-) (R, S) ethyl ester was prepared according to this procedure yl) -propionyl] -3,4-dihydro-2H-benzo [1,4] oxazin-7-yl} butanoic acid in the form of a colorless gum.

Reference Example 11 (a) (R, S) -3- (4-tert-Butyloxycarbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) ethyl ester 284

-5-methylhexane

A reaction mixture containing (E) - and (Z) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -5-methylhexyl ester was used. -2-eno [240 milligrams, Reference Example 4 (b)] and 10% palladium on charcoal (40 milligrams) in ethanol (30 milliliters) treated with solid ammonium formate (2 grams) and then heated at at 60 ° C for 1 hour. Additional aliquots of palladium on activated carbon (40 milligrams) were added every hour at 5 hour intervals. After cooling to room temperature, the reaction mixture was filtered through diatomaceous earth and the filtrate was evaporated to a small volume, then partitioned between ethyl acetate (50 ml) and water (50 ml). The organic phase was dried over magnesium sulfate and evaporated to give the title compound.

Yield: 200 g.

(b)

In a similar manner to that described in Reference Example 11 (a), except that (E) - and (Z) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzoic acid ethyl ester) is used. [1,4] oxazin-7-yl) -4-methylpent-2-eno [Reference Example 4 (c)] to give (R, S) -3- (4-tert-butyloxy-) ethyl ester carbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -4-methylpentanoic acid.

(C)

In a similar manner to that described in Reference Example 11 (a), except that it is used

285 (E) - and (Z) -3- (4-tert-Butyloxycarbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-phenylprop-2-enoic acid ethyl ester [ Reference Example 4 (d)] to obtain (R, S) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzo [1,4] oxazine-7-) ethyl ester yl) -3-phenylpropanoic.

(d)

In a similar manner to that described in Reference Example 11 (a), except that (E) - and (Z) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzoic acid ethyl ester) is used. [1,4] oxazin-7-yl) -3-o-tolylprop-2-eno [Reference Example 4 (e) 3 to give (R, S) -3- (4-tert- butyloxycarbonyl-3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) -3-o-tolylpropanoic acid.

(E)

In a similar manner to that described in Reference Example 11 (a), except that (E) - and (Z) -3- (4-tert-butyloxycarbonyl-3,4-dihydro-2H-benzoic acid ethyl ester) is used. [1,4] oxazin-7-yl) -but-2-enoic acid [Reference Example 4 (f)] to give (R, S) -3- (4-tert-butyloxy-carbonyl- 3,4-dihydro-2H-benzo [1,4] oxazin-7-yl) butanoic acid as a colorless oil.

Reference Example 12

7-Bromo-3,4-dihydro-2H-benzo [1,4] oxazine

A solution containing 4-acetyl-7-bromo-3,4-dihydro-2H-benzo [1,4] oxazine (9.5 g,

286

Reference Example 13) in methanol (200 mL) was treated with aqueous sodium hydroxide solution (50 mL, 3 M solution) and then stirred at 50 ° C for 2 hours. The reaction mixture was concentrated to a small volume, diluted with water (100 mL) and extracted three times with dichloromethane (200 mL). The combined extracts were dried (MgSO 4) and evaporated to give the title compound as a brown oil.

Yield: 6.0 g.

Reference Example 13

4-Acetyl-7-bromo-3,4-dihydro-2H-benzo [1,4] oxazine

A mixture containing 4-bromo-2-hydroxyacetanilide (9.4 grams), powdered sodium hydroxide (6.56 grams), aliquat 336 (2.0 grams), and 1,2-dibromoethane (30.8 grams) was used. g) in a mixture of dichloromethane (100 ml) and acetonitrile (60 ml), the reaction mixture was stirred at room temperature for 16 hours and allowed to stand for 24 hours. The mixture was filtered through diatomaceous earth, and the filter pad was washed with dichloromethane. The filtrate and washings were combined and evaporated to give a residue which was purified by flash chromatography (silica eluting with ethyl acetate / cyclohexane 1: 1) to give the title compound as described above. in the form of a light oil.

287

Yield: 9.5 g.

Reference Example 14

3- (2-O-Tolylamino-benzoxazol-6-yl) -propanoic acid

A solution containing 3- (2-o-tolylamino-benzoxazol-6-yl) -propanoic acid ethyl ester (Reference Example 15) in methanol (50 mL) was treated with aqueous sodium hydroxide solution (5 mL). , 1 M solution). After stirring at 40 ° C for 2 hours, the reaction mixture was concentrated to a small volume and partitioned between ethyl acetate (50 mL) and water (50 mL). The aqueous phase was separated and acidified with aqueous hydrochloric acid (10 mL, 1 M solution). The resulting precipitate was dried at 60 ° C to give the title compound as described above.

Yield: 1.1 g.

Reference Example 15

3- (2-O-Tolylamino-benzoxazol-6-yl) -propanoic acid ethyl ester.

A solution containing 3- (4-amino-3-hydroxyphenyl) -propionic acid ethyl ester (1.94 g) in ethanol (50 mL) was treated with o-tolylisothiocyanate (1.66 g) and then The mixture was heated at 40 ° C for 2 hours.

The reaction mixture was evaporated and treated with ethanol (50 mL) and worked up

288

diisopropylcarbodiimide (3 mL) and then stirred at 40 ° C for 1 hour.

The reaction mixture was evaporated and the residue was treated with diethyl ether (50 mL) and then filtered. The filtrate was evaporated to dryness and the residue was flash chromatographed on silica gel using ethyl acetate / cyclohexane (2: 3 by volume) to give the title compound as a colorless oil. . Yield: 1.6 g.

Reference Example 16 (a) 3- (4-Benzoyl-1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetraethyl ethyl ester -hydroquinoxalin-6-yl) butyric acid

According to this procedure, benzoyl chloride (22 μΐ) was added to the stirred mixture containing 3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} 1,2,3-ethyl ester, 4-tetrahydro-quinoxalin-6-yl) -butyric acid (0.110 g, Reference Example 17) and triethylamine (87.8 μΐ) in tetrahydrofuran (10 mL) cooled to 0 ° C under argon. The reaction mixture was stirred for 1 hour at 0 ° C, then allowed to warm to 20 ° C, then stirred at this temperature for 2 hours and then treated with an additional aliquot of benzoyl chloride (11 µΐ). After stirring overnight, the reaction mixture was treated with water (20 mL) and then extracted three times with ethyl acetate (25 mL). The extracts were combined and dried

289

magnesium sulfate (40 ° C, 40 mbar, 4000 Pa). The crude residue (147 mg) was flash chromatographed on silica (20 grams, particle size 0.040-0.063 mm), eluting with dichloromethane: methanol (99: 1, v / v). The title compound was obtained as a white foam as described above.

Yield: 132 mg.

TLC: Rp 13/56 (cyclohexane: ethyl acetate 9: 1 by volume).

^{Χ Η} NMR [400 MHz, (CD _{3) 2} SO, at a temperature of 383 ° K]: δ

0.96 (d, J = 7Hz, 3H), 1.16 (t, J = 7Hz, 3H),

2.24 (d, J = 7.5Hz, 2H), 2.28 (s, 3H), 2.93 (m, 1H),

3.83 (s, 3H), 3.94 (m, 2H), 3.96 (s, 2H), 4.02 (m, 2H),

4.04 (q, J = 7Hz, 2H), 6.63 (s band, 1H),

6.76 (band d, J = 8 Hz, 1H), 6.90 (band s, 1H), 6.99 (m, 2H),

7.10-7.20 (m, 4H), 7.34 (t band, J = 7.5 Hz, 2H),

7.41 (t band, J = 7.5 Hz, IH), 7.57 (d, J = 8 Hz, IH),

7.67 (band d, J = 8Hz, IH), 8.02 (d, J = 8.5Hz, IH),

8.16 (band s, 1H), 8.24 (band s, 1H).

MS (EI): 648 (M ^& lt ^{; +} & gt ^; ).

(b)

Using a procedure similar to that described in Reference Example 16 (a), except that acetyl chloride and ethyl 3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -phenyl] - acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propanoic acid (Reference Example 1), and the reaction product was subjected to flash chromatography on silica, eluting with a mixture of: cyclohexane and ethyl acetate (6: 4 to 7: 3 by volume), wherein

290

3- (4-acetyl-1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-ethyl ester was prepared according to the above procedure (quinoxalin-6-yl) -propionic acid in the form of a white foam.

¹ H NMR [300 MHz, (CD ₃ ) ₂ SO, at room temperature, mixture of rotamers]: δ

1.17 (d, J = 7Hz, 3H), 1.85-2.15 (broad band, 3H),

2.26 (s, 3H), 2.65 (t band, J = 7.5 Hz, 2H),

2.86 (t band, J = 7.5 Hz, 2H), 3.70-3.95 (m, 9H),

4.06 (m, 2H); 6.40-7.70 (m, 8H);

7.81 (band d, J = 8 Hz, 1H), 7.95 (broad band, 1H),

8.48 (s band, 1H), 8.56 (broad band, 1H).

MS (EI): 572 (M ^& lt ^{; +} & gt ^; ).

(C)

Using a procedure similar to that described in Reference Example 16 (a), except that 3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl) ethyl ester was used. } -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propanoic acid (Reference Example 1) to give 3- (4-benzoyl-1 - {[3-methoxy-4- (3-methoxy-4-) - (ethyl) -acetate) -o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -propanoic acid in the form of a white powder, followed by trituration with diisopropyl ether.

1 H NMR [400 MHz, (CD ₃ ) ₂ SO at room temperature, mixture of rotamers]: δ

1.17 (d, J = 7Hz, 3H), 2.14 (t band, J = 7.5Hz, 2H),

2.24 (s, 3H), 2.51 (m, 2H), 3.80 (s, 3H), 3.89 (m, 2H),

3.90-4.00 (m, 2H), 3.97 (s, 2H), 4.02 (m, 2H),

6.48 (broad band, 1H), 6.71 (broad band, 1H),

6.90-7.25 (m, 6H), 7.31 (t band, J = 7.5 Hz, 2H),

7.40 (t band, J = 7.5 Hz, 1H), 7.60 (broad band, 1H),

7.77 (band d, J = 8Hz, 1H), 8.06 (d, J = 8.5Hz, 1H),

291> 44

44 44 444

8.47 (s, 1H), 8.54 (s, 1H).

MS (EI): 634 (M ^& lt ^{; +} & gt ^; ).

(d)

Using a procedure similar to that described in Reference Example 16 (a), except that ethyl succinyl chloride and ethyl acid ester were used.

3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} 1,2,3,4-tetrahydro-quinoxalin-6-yl) -propanoic (Reference Example 1) The reaction product was flash chromatographed on silica gel using cyclohexane / ethyl acetate (9: 1 to 1: 1 by volume) to give the ethyl ester as described above. acid

4- (7- (2-ethoxycarbonyl-ethyl) -4 - {[3-methoxy-4- (3-o-tolylureido) -phenyl] -acetyl} -3,4-dihydro-2H-quinoxalin-1-yl -4-oxo-butane in the form of a white foam.

1 H NMR [400 MHz, (CD ₃ ) ₂ SO at room temperature, mixture of rotamers]: δ

1.16 (m, 6H), 2.26 (s, 3H), 2.52 (m, 2H),

2.64 (t band, J = 7.5 Hz, 4H), 2.87 (t band, J = 7.5 Hz, 2H), 3.75-3.90 (m, 9H), 4.05 (m, 4H)

6.50 - 6.85 (very wide band, 2H),

6.95 (t band, J = 7.5 Hz, 1H), 7.05-7.20 (m, 3H),

7.30 - 7.75 (very wide band, 2H), 7.79 (d, J = 8 Hz, IH), 8.00 (band d, J = 8 Hz, IH), 8.21 (band with , IH),

8.27 (broad band, 1H).

MS (EI): 658 (M ^& lt ^{; +} & gt ^; ).

Reference Example 17

3- (1 - {[3-Methoxy-4- (3-o-tolyl-ureido) -ethyl] -ethyl ester 292 292 · · · · · · · · · · · · »···

-phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl) -butyric acid

According to this embodiment, trifluoroacetic acid (574 μΐ) was added to a stirred solution containing 7- (2-ethoxycarbonyl-1-methylethyl) -4 - {[3-methoxy-4- (3-o-tolyl-ureido) tert -butyl ester] -phenyl] -acetyl} 3,4-dihydro-2H-quinoxaline-1-carboxylic acid (376 mg, Reference Example 18) in dichloromethane (4 mL) 0 ° C. After stirring the reaction mixture at 0 ° C for 2 hours, an additional aliquot of trifluoroacetic acid (3.5 mL) was added and stirring at 0 ° C for an additional 4 hours. The reaction mixture was then poured onto a mixture of ice (75 mL) and sodium hydroxide solution (55 mL, 1 M solution). The resulting reaction mixture was extracted three times with dichloromethane (50 mL). The combined extracts were washed twice with water (20 ml), dried over magnesium sulfate and then evaporated (40 mbar, 4000 Pa, 40 ° C). The residue was flash chromatographed (20 g silica, particle size 0.040-0.063 mm), eluting with dichloromethane: methanol (99: 1, v / v) to give the title compound as a colorless solid. the title compound as a white powder.

Yield: 279 mg.

TLC: Rp 43/64 (dichloromethane: methanol, 9: 1) ¹ H NMR [250 MHz, (CD ₃ ) ₂ SO, at 373 ° K]: δ

1.16 (t, J = 7Hz, 3H), 1.23 (d, J = 7.5Hz, 3H), 1,23 (d, J = 7.5Hz, 3H), 2.28 (s, 3H), 2.45 - 2 55 (m, 2H); 3.06 (m, 1H); 3.25 (m, 2H). 3.69 (m, 2H), 3.82 (s, 2H), 3.85 (s) s, 3H),

293

4.05 (q, J = 7Hz, 2H), 5.73 (broad band, 1H),

6.43 (dd, J = 8 and 2 Hz, 1H), 6.50 (d, J = 2 Hz, IH),

6.70 (dd, J = 9 and 1.5 Hz, IH), 6.81 (d, J = 1.5 Hz, IH),

6.97 (t band, J = 7.5 Hz, 1H),

7.10 - 7.30 (m, 3H), 7.71 (band d, J = 9 Hz, 1H),

7.98 (d, J = 8.5 Hz, 1H), 8.25 (s band, 1H),

8.29 (band s, 1H).

MS (EI): 544 (M ^& lt ^{; +} & gt ^; ).

Reference Example 18

7- (2-ethoxycarbonyl-1-methyl-ethyl) -4 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -3,4-dihydro- 2H-quinoxaline-1-carboxylic acid.

A mixture containing [3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetic acid (0.563 grams) and tert-butyl ester was used in this example.

7- (2-ethoxycarbonyl-1-methyl-ethyl) -3,4-dihydro-2H-quinoxaline-1-carboxylic acid (396 milligrams, Reference Example 19) in tetrahydrofuran (10 ml) containing a molecular sieve of 4 Angstroms (0, This mixture was treated with triethylamine (638 μΐ), O- (7-azabenzotriazoll-yl) -Ν, Ν, Ν ', N'-tetramethyluronium hexafluorophosphate (518 milligrams) and 4-dimethylaminopyridine (14 g). milligrams). After stirring for 5 hours, additional aliquots of [3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetic acid (0.178 g) and O- (7-azabenzotriazole-) were added. 1-yl) - Ν, Ν, Ν ', N'-tetramethyluronium hexafluorophosphate (172 mg) and stirring for an additional 18 hours. The reaction mixture was filtered through celite, and the filter pad was washed with ethyl acetate (50 mL).

294

The filtrate and washings were combined, washed three times with aqueous saturated ammonium chloride solution (20 mL), dried over magnesium sulfate and evaporated (40 ° C, 40 mbar). The residue (1.2 g) was chromatographed (36 g silica, particle size 0.040-0.063 mm), eluting with cyclohexane / ethyl acetate (70/30; v / v). the title compound was obtained as a white powder as described above.

Yield: 379 mg.

TLC: Rp 15/65 (cyclohexane: ethyl acetate, 1: 1) ⁴ H NMR [400 MHz, (CDCl 3 SO 2 at room temperature, mixture of rotamers observed): δ

1.14 (t, J = 7Hz, 3H), 1.24 (d, J = 7Hz, 3H),

1.48 (s, 9 Η), 2.26 (s, 3H), 2.58 (d, J = 7.5 Hz, 2 Η),

3.17 (m, 1H), 3.64 (m, 2H), 3.75-3.90 (m, 7H),

4.04 (q, J = 7Hz, 2H), 6.55-6.85 (broad band, 2H),

6.96 (t, J = 7.5 Hz, 1H), 7.00 (band d, J = 8 Hz, 1H),

7.10 - 7.20 (m, 2H), 7.46 (broad band, 1H),

7.64 (band s, 1H), 7.78 (d, J = 8Hz, 1H),

8.01 (d, J = 8 Hz, 1H), 8.48 (s, 1H), 8.54 (band s, 1H).

MS (EI): 644 (M ^& lt ^{; +} & gt ^; ).

Reference Example 19

7- (2-Ethoxycarbonyl-1-methyl-ethyl) -3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester

4-Benzyl-7- (2-ethoxycarbonyl-1-methylvinyl) -3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester (0.905 g, 9.90) was used _.

9

9 9 9 9 9

295

999 99 99 999

Reference Example 20) was added to a stirred suspension containing palladium dihydroxide on carbon (240 milligrams, 20%) in acetic acid, after which the reaction mixture was subjected to hydrogenation (30 bar, 3 MPa) at 15 ° C. overnight. The resulting crude mixture was filtered through a pad of celite and the filter pad was washed with ethyl acetate. The combined filtrate and washings were evaporated (40 mbar, 4000 Pa, 40 ° C). The residue was chromatographed (30 grams silica, particle size 0.040-0.063 mm), eluting with dichloromethane to give the title compound as a colorless oil.

Yield: 485 mg.

TLC: Rf 25/65 (volume ratio of cyclohexane: ethyl acetate, 7: 3) ^X H NMR (400 MHz, (CD _{3) 2} SO): δ

1.14 (m, 6H), 1.48 (s, 9H), 2.47 (d, J = 7.5Hz, 2H),

3.00 (m, 1 H), 3.22 (m, 2 H), 3.57 (m, 2 H),

4.01 (q, J = 7Hz, 2H), 5.90 (broad band, 1H),

6.47 (d, J = 8Hz, 1H), 6.70 (dd, J = 8Hz and 2Hz, 1H),

7.20 (broad band, 1H).

MS (EI): 348 (M ^& lt ^{; +} & gt ^; ).

Reference Example 20

4-Benzyl-7- (2-ethoxycarbonyl-1-methyl-vinyl) -3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester

A mixture containing 3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -ethyl ester was used in this example. ··· ·· * · · · · · ·

296

1,2,3,4-tetrahydro-quinoxalin-6-yl) -propionic acid (4.4 grams, Reference Example 1), tributylamine (50 milliliters), tri-ortho-tolylphosphine (177 milligrams) and palladium acetate (444 milligrams) The reaction mixture was heated at 80 ° C for 15 minutes, then treated with ethyl crotonate (2.74 ml) and the resulting mixture was heated at 120 ° C overnight. After cooling the reaction mixture to 20 ° C, the reaction mixture was treated with hydrochloric acid (350 mL, 1 M solution) and then extracted four times with ethyl acetate (200 mL). The combined extracts were washed with saturated aqueous sodium bicarbonate (200 ml) and then with water (200 ml), dried over magnesium sulphate and then evaporated. The residue was chromatographed on silica (260 grams, 0.04-0.063 mm), eluting with cyclohexane / ethyl acetate (95: 5) to give the title compound. in the form of a colorless oil.

Yield: 910 mg.

⁴ H NMR (400 MHz, (CD ₃ ) ₂ SO): δ

1.23 (t, J = 7Hz, 3H), 1.49 (s, 9H),

2.47 (d, J = 1.5Hz, 3H), 3.49 (m, 2H), 3.78 (m, 2H),

4.11 (q, J = 7Hz, 2H), 4.62 (s, 2H), 6.04 (m, 1H),

6.64 (d, J = 9 Hz, 1 H), 7.19 (dd, J = 9 and 2 Hz, 1 H),

7.27 (m, 3H), 7.36 (t band, J = 7.5 Hz, 2H),

7.63 (s band, 1H).

MS (EI): 436 (M ^& lt ^{; +} & gt ^; ).

Reference Example 21

3- (4- (3-Dimethylamino-propionyl) -1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-ethyl ester (quinoxalin-6-yl) -propanoic acid.

The stirred mixture containing ethyl 3- (4-acryloyl-1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4- tetrahydro-quinoxalin-6-yl) -propanoic acid (283 milligrams, Reference Example 22) and methylamine (115 μΐ) in ethanol (5 ml) were heated at reflux for 8 hours and then treated with another aliquot of methylamine ( 50 μΐ) and then the mixture was heated at reflux for a further 2 hours. The reaction mixture was cooled to 20 ° C, diluted with ethyl acetate and then treated with hydrochloric acid (50 mL, 0.1 M solution) and partitioned. The ethyl acetate phase was washed with a saturated aqueous sodium bicarbonate solution (10 ml), washed three times with water (10 ml), dried over magnesium sulfate and evaporated under reduced pressure. The aqueous phase from the above process was extracted three times with dichloromethane (50 mL). The individual dichloromethane extracts were combined with the above ethyl acetate residue, dried over magnesium sulfate and then evaporated under reduced pressure. The crude residue (331 mg) was subjected to flash chromatography on silica (30 g, particle size 0.040-0.063 mg), eluting with dichloromethane: methanol (99: 1 to 96: v / v). 4), whereby the desired process was prepared by the above process

298 title compound in the form of a white foam.

Yield: 275 mg.

¹ H NMR [400 MHz, (CD ₃ ) ₂ SO, at 383 ° K]: δ

1.20 (t, J = 7Hz, 3H), 2.19 (s, 6H), 2.28 (s, 3H),

2.55-2.70 (m, 6H), 2.75-3.00 (m, 2H),

3.80-3.90 (m, 2H), 3.83 (s, 2H), 3.86 (s, 3H),

3.90 (m, 2H), 4.11 (q, J = 7Hz, 2H),

6.67 (band d, J = 8 Hz, 1H), 6.81 (band s, IH),

6.99 (t band, J = 7.5 Hz, 1H), 7.05-7.25 (m, 3H),

7.42 (band s, 1H), 7.56 (d, J = 8.5 Hz, 1H),

7.69 (band d, J = 8Hz, IH), 7.98 (d, J = 8.5Hz, IH),

8.17 (band s, 1H), 8.25 (band s, 1H).

MS (CI): 630 (MH ^&lt; ^{+ &gt;} ).

Reference Example 22

3- (4-Acryloyl-1 - {[3-methoxy-4- (3-o-tolyl-ureido) -phenyl] -acetyl} -1,2,3,4-tetrahydro-quinoxalin-6-yl ethyl ester ) -propane.

According to this procedure, 3-bromopropionyl bromide (262 μΐ) was added to a stirred suspension containing 3- (1 - {[3-methoxy-4- (3-o-tolyl-ureido) phenyl] -acetyl} -1,2-ethyl ester 3,4-tetrahydro-quinoxalin-6-yl) -propine (0.229 g, Reference Example 1) and triethylamine (680 μΐ) in tetrahydrofuran (10 mL) cooled to 0 ° C under argon. After stirring at 0 ° C for 1 hour and then at 20 ° C overnight, the resulting mixture was treated with 3-bromopropionyl bromide (90 μΐ) and stirred for 2 hours. hours at 21 ° C. The reaction mixture was treated with water (25 mL) and stirred

299

After stirring for 15 minutes at 20 ° C, the reaction mixture was extracted three times with ethyl acetate (25 mL). The combined extracts were washed with saturated aqueous sodium bicarbonate (10 mL), washed four times with water (10 mL), dried over magnesium sulfate and finally evaporated to dryness under reduced pressure (40 ° C). , 40 mbar, which is 4000 Pa). The residue (1.7 g) was subjected to flash chromatography on silica (50 g, particle size 0.040-0.063 mg) eluting with cyclohexane / ethyl acetate (1: 1, v / v / v). to give the title compound as a yellow foam.

Yield: 550 mg.

TLC: Rf = 30/72 silica, eluent dichloromethane / methanol 9: 1 v / v).

⁴ H NMR [400 MHz, (CD ₃ ) ₂ SO, at 373 ° K]: δ

1.20 (t, J = 7Hz, 3H); 2.28 (s, 3H);

2.64 (t, J = 7.5Hz, 2H), 2.91 (t, J = 7.5Hz, 2H),

3.81 (s, 3H), 3.84 (s, 2H), 3.87 (m, 2H), 3.93 (m, 2H),

4.11 (q, J = 7Hz, 2H), 5.68 (dd, J = 10.5 and 2Hz, 1H),

6.21 (dd, J = 17 and 2 Hz, 1 H),

6.38 (dd, J = 17 and 10.5 Hz, 1H),

6.58 (band d, J = 8 Hz, 1H), 6.75 (band s, 1H),

6.99 (t band, J = 7.5 Hz, 1H), 7.10-7.25 (m, 4H),

7.57 (d, J = 8.5 Hz, 1H), 7.69 (band d, J = 8 Hz, 1H),

7.92 (d, J = 8.5 Hz, 1H), 8.18 (s band, 1H),

8.28 (s band, 1H).

MS (EI): 584 (M ^& lt ^{; +} & gt ^; ).

300

In vitro and in vivo tests

Inhibitory effects of compounds on VLA4-dependent cell adhesion to fibronectin and VCAM

1.1 Metabolic labeling of RAMOS cells

RAMOS cells (pre-B cell line, from ECACC, Porton Down, UK) are grown in RPMI culture medium (Gibco,

UK) supplemented with 5% fetal calf serum (FCS, Gibco, UK). Prior to assay, cells are resuspended to a concentration of 0.5 x 10 6 cells / ml RPMI and labeled with 400 µCi / 100 ml [ ³ H] -methionine (Amersham, UK) for 18 hours at 37 ° C.

1.2. Preparation of 96-well plates for adhesion tests

Cytostar plates (Amersham, UK) were coated with 50 μΐ / well of either 3 pg / ml human soluble VCAM-1 (R&D Systems Ltd., UK) or 28.8 pg / ml human tissue fibronectin (Sigma, UK). 50 µl of phosphate buffered saline was added to the non-specific binding control wells. The plates were then dried in an incubator at 25 ° C overnight. The next day, the plates were blocked with 200 µl / well of Pucks buffer (Gibco, UK) supplemented with 1% BSA (Sigma, UK). Plates were left in the dark at room temperature for 2 hours. The blocking buffer was then removed and the plates dried by inverting and gently tapping the paper. 50 µl / well of 3.6% dimethylsulfoxide in Pucks buffer supplemented with 5 mM manganese chloride (for integrin receptor activation, Sigma, UK) and 0.2% were added to appropriate wells for binding assays and non-specific binding assays. BSA (Sigma, UK). 50 µl / well of test compounds in the respective wells were added to the assay wells

301

concentrations diluted with 3.6% dimethylsulfoxide in Pucks buffer supplemented with 5 mM manganese chloride and 0.2% BSA.

Metabolically labeled cells were suspended at 4 x 10 ^b cells / ml in Pucks buffer supplemented with manganese chloride and BSA as above. 50 μΐ / well of cells in 3.6% dimethylsulfoxide in supplemented Pucks buffer was added to all wells on the plate.

For VCAM-1 or fibronectin coated plates, the same procedure existed and it was examined how the compound inhibited cell binding to both substrates.

1.3 Test performance and data analysis

Plates containing cells in control or test compound wells were incubated for 1 hour in the dark at room temperature.

Plates were then read on a Vallac Microbeta scintillation counter (Vallac, UK) and the data was processed by Microsoft Excel (Microsoft, US). Data were expressed as IC 50, the inhibitor concentration at which 50% binding occurred in the control samples. The percentage of bonds was determined from the equation:

{t (CTB ^- Cnc9 ^{- -} CNS) J / (CTB ^_ CNS) ^x ιθθ ⁼ °? ° ^relation y where Cyg pulses are bound to the wells coated with fibronectin (or VCAM-1) without the occurrence of inhibitor, C ^ g pulses are occurring are in wells without substrate and Cj are pulses from wells containing a cell adhesion inhibitor.

302

Data for compounds of the present invention are expressed in the form of IC 50 for inhibition of cell adhesion to fibronectin and VCAM-1. Particular compounds of the invention inhibit cell adhesion to fibronectin and VCAM-1 with an IC 50 of 100 gmol to 0.1 nmol. Preferred compounds of the invention inhibit cell adhesion to fibronectin and VCAM-1 with an IC 50 of between 10 nmol and 0.1 nmol.

2. Inhibition of antigen-induced airway inflammation in mice and rat

Animal sensitization

Rats (Brown Norway, Harland Olac, UK) were sensitized on days 0, 12 and 21 with ovalbumin (100 gg, intraperitoneally, (i.p.), Sigma, UK) administered with aluminum hydroxide adjuvant (100 mg, i.p., Sigma,

In saline (1 ml, i.p.).

In addition, mice (C57) were sensitized on days 0 and 12 with ovalbumin (10 gg, i.p.) administered with aluminum hydroxide adjuvant (20 mg, i.p.) in saline (0.2 ml, i.p.).

2.2

Rats were stimulated on any day between days 28 to 38, while mice were stimulated on any day between days 20 to 30.

Animals were stimulated by exposure to 30 minutes (rats) or 1 hour (mice) of an ovalbumin aerosol (10 g / l) generated by an ultrasonic nebulizer.

303 ·· · · · ♦ φ ΦΦ φ φ de de de de de de (deVilbiss Ultraneb, US) and admitted to the exposure chamber.

2.3 Care protocols

Animals were treated as needed before or after the antigen challenge. The water-soluble compounds of the present invention may be formulated in water (for oral, p.o., dosing) or saline (for intratracheal, i.t., administration). Insoluble compounds were prepared as suspensions by grinding and sonicating the solid in 0.5% methylcellulose / 0.2% polysorbate 80 in water (for after administration, both by Merck UK Ltd., UK) or in saline (for it administration). were: for rats 1 ml / kg, po or 0.5 ml / kg i.t., for mice 10 ml / kg, p.o. or 1 ml / kg, i.t.

2.4 Determination of airway inflammation

Cell accumulation in the lung was determined 24 hours post challenge (rat) or 48-72 hours post challenge (mice). Animals were euthanized with sodium pentobarbital (200 mg / kg, i.p., Pasteur Merieux, France) and the cannula was immediately inserted into the trachea. Cells were harvested from the airway lumen by bronchoalveolar lavage (BAL) and from lung tissue by enzyme (collagenase, Sigma, UK) digestion as described below.

BAL was performed by rinsing the airways with 2 aliquots (10 ml / kg each) of RPMI 1640 medium (Gibco, UK) containing 10% fetal calf serum (FCS, Serotec Ltd.,

UK). The obtained BAL aliquots were pooled and cells were counted as described below.

• · 4

304 • ·· ·· · · ··· ··

4 ··

444

Immediately after BAL, pulmonary vascular supply was flushed with RPMI 1640 / FCS to remove blood cells. The lung lobes were removed and cut into 0.5 mm pieces. Samples (rats: 400 mg, mice: 150 mg) of homogenous lung tissue were incubated in RPMI 1640 / FCS with collagenase (20 U / ml for 2 hours, then 60 U / ml for 1 hour, 37 ° C) to separate from the tissue. cells. The obtained cells were washed in RPMI 1640 / FCS.

Counting of all leukocytes obtained from the lumen of the airways and lung tissue was performed by an automated cell counter (Cobas Argos, US). Differential counts of eosinophils, neutrophils, and mononuclear cells were read by light microscopy from cell preparations obtained by centrifugation stained by Vright-Giemz (Sigma, UK).

T lymphocytes were counted by flow cytometry (EPICS XL, Coulter Electronics, US) using fluorophore labeled anti-CD2 antibodies (a general marker of T cells used for total T cell quantitation), CD4, CD8, and CD25 (activated T cell marker). All antibodies were supplied by Serotec Ltd., UK.

2.5 Data Analysis

Cell data was expressed as the mean cell numbers of the non-stimulated, stimulated and vehicle treated groups, and the stimulated and compound treated groups, including the mean error of the mean. Statistical analysis of the difference between treatment groups was evaluated using a one-factor analysis of variance by Mann-Vhitney test. No statistical significance was achieved at p <0.05.

Claims (99)

PATENT CLAIMS 1. A compound of formula I: in which: R ¹ represents a group selected from (i) R ³ -Z ³ (ii) R ³ -L ² -R ⁴ -Z ³ (iii) R ³ -L ³ -Ar ¹ -L ⁴ -Z ³ (iv) ) R ³ -L ³ -Ar ¹ -L ² -R ⁴ -Z ³ -, R is hydrogen, halogen, lower alkyl or lower alkoxy; and R represents alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkinyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkinyl, cycloalkenyl, cycloalkenyl, heteroaryalkenylalkyl, heteroaryalkenylalkyl, heteroaryalkenyl, heteroarylalkinyl, heterocycloalkyl or heterocycloalkylalkyl; 306 R ⁴ represents an alkylene group, an alkenylene group or an alkynylene group; R 8 represents a hydrogen atom or a lower alkyl group; R 0 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an arylalkyl group, a cycloalkyl group, a cycloalkylalkyl group, a heteroaryl group or a heteroarylalkyl group; R 'represents a hydrogen atom or a lower alkyl group; O R is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R ⁹ represents an alkyl group, an aryl group, a cycloalkyl group, a heteroaryl group or a heterocycloalkyl group or an alkyl group substituted with an aryl group, an acidic functional group, a cycloalkyl group, a heteroaryl group, a heterocycloalkyl group, -S (O) _m R 6, -C ( = O) -NY ⁴ Y ^ or -NY ⁴ Y ^5; 10 3 R is hydrogen, R or alkyl substituted with alkoxy, cycloalkyl, hydroxy, mercapto, alkylthio or -NY ⁴ Y ⁵ ; 11 11 R and R are independently of each other ΦΦ · ·· 6 · Φ · ΦΦΦ 307 Φ ΦΦ ΦΦΦ ΦΦ is selected from the group consisting of α q amino acid side chains, an acidic functional group, R, -C (= O) -R, or -C (= O) -NY ⁴ Y ³ , or an alkyl group substituted with R ³ , - NY ⁴ Y ⁵ , -NH-C (= O) -R ³ , -C (= O) -R ⁴ -NH 2, -C (= O) -Ar ¹ -NH 2, -C (= O) -R ⁴ -CO ₂ H or -C (= O) -NY ⁴ Y ⁵ ; Or R and R or R and R together with the atoms to which they are attached form a three to six membered heterocyclic ring, 1 9 R ⁶ represents an alkylene group containing 1 to 6 O carbon atoms, optionally substituted with R; R ¹⁴ is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R ¹² represents a hydrogen atom, R ⁹ , -C (= O) -R ⁹ , -C (= O) -OR ¹⁴ or -SO ₂ R ⁹ ; A ¹ represents a C 2 -C 3 alkylene bond optionally substituted by one or more groups selected from alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, amino, oxo, thioxo, or substituted alkyl -ZR ⁶ , -NY ⁴ Y ² , -CO ₂ R ⁶ or -C (= O) -NY ¹ Y ² ; Ar ¹ represents an arylene group or a heteroaryldiyl group; 308 Τ1 L is (i) a direct bond, (ii) an alkenylene group, an alkylene group, an alkynylene group, a cycloalkenylene group, a cycloalkylene group, a heteroaryldiyl group, a heterocycloalkylene group, or an arylene bond, each optionally substituted by an acidic functional group, cyano group , oxo, -S (O) _m R ⁹ , R ³ , -C (= O) -R ³ , -C (= O) -OR ³ , -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ R ⁹ , -NY ⁴ Y ⁵ or _ [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ )] -C (= O) -NY ⁴ Y ⁵ , or (b) an alkyl group substituted with an acidic functional group or -S (O) _m R ⁹ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ ; (iii) - [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ )] _p - linkage, (iv) Z ² -R ¹² - linkage; (v) -C (= O) -CH ₂ -C (= O) - linkage; (vi) -R ¹² -Z ² -R ¹² - linkage, (vii) -C (R ⁵ ) (R ¹³ ) - [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹⁾ )] _p - join or (viii) -L ⁵ -L ⁵ -L ² - join, L ² is -NR ⁵ -C (= Z) -NR ⁵ -, -C (= Z) -NR ⁵ -, -C (= O) -, -C (= Z) -O-, -NR ⁵ - C (= Z) -, -Z-, -SO-, -SO 2 -, -NR ⁵ -, -SO ₂ -NR ⁵ -, -NR ⁵ -SO ₂ -, -NR ⁵ -C (= O) -O -, -O-C (= O) -, or -O-C (= O) -NR ⁵ connection, L ³ represents a heteroaryldiyl group, a heterocycloalkylene group, -NR -C (= Z) -NR -, -C (= Z) -NR ⁵ -, -C (= Z) -O-, -NR ⁵ -C (= Z) -, -Z-, -S0-, -S0 ₂ -, -NR ⁵ -, -SO 2 NR ⁵ -, -NR ⁵ -SO 2, -NR ⁵ -C (= 0) -0-, -0-C (= 0) -, or -O-C (= 0) -NR ⁵ - connection, • 9 · · 9 · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 4 4 4 4 4 4 4 4 4 309 ··· 44 94 9 44 L ⁴ represents a direct bond, an alkylene group, an alkenylene group or an alkynylene group; L ³ and L? each independently represents a direct bond or an alkylene group, L ⁶ represents a cycloalkylene group or a heterocycloalkylene group, Y represents a carboxy group (or an acid bioisoster), Y - * - and Y are each independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl or heteroarylalkyl, or -NY Y may form a cyclic amine, Y ⁴ and R ⁴ are each independently hydrogen, alkenyl, alkyl, alkynyl, aryl, cycloalkenyl, cycloalkyl, heteroaryl, heterocycloalkyl, or alkoxy-substituted alkyl, aryl, cyano, cycloalkyl, heteroaryl, heterocycloalkyl, hydroxy, oxo, -NY ^A Y, or one or more -CO ₂ R or -C (= O) -ΝΥ- * · γ2, or NY ⁴ Y ⁴ may form a five member to a seven membered cyclic amine which (i) may be optionally substituted with one or more substituents selected from the group consisting of alkoxy, carboxamide, carboxy, hydroxy, oxo (or a five, six, or seven membered cyclic acetal derivative thereof), · · Φ φ Φ · Φ 9 9 9 4 4 • ΦΦΦ Φ • • • • • • • Φ · Φ ΦΦ Φ · Φ ΦΦ ΦΦ 310 (ii) may also contain an additional heteroatom selected from O, S, SO ₂ , or NY; (iii) may also be fused to additional aryl, heteroaryl, heterocycloalkyl or cycloalkyl rings to form a bicyclic or tricyclic ring system, Y is a hydrogen atom, alkyl, aryl, arylalkyl, -C (= O) -R · ^4, -C (= O) -OR ¹⁴ or -SO ₂ R ^14, Z is an oxygen or sulfur atom, Z is NR or O; Z ² is O, S (O) _n , NR ⁵ , SONR ⁵ , C (= O) NR ⁵ or C (= O); Z ³ is C (= O), OC (= O), NR ⁵ C (= O), or SO ₂ ; m is 1 or 2, n is zero or 1 or 2, and p is zero or 1 to 4, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N-oxides and prodrugs, but excluding compounds in which an oxygen, nitrogen or sulfur atom is attached directly to the carbon-carbon multiple bond of an alkenylene, alkynylene or cycloalkenylene moiety, 4 9 9 9 9 99 99 99 99 99 99 99 99 99 99 99 99 99 99 99 99 311 A compound according to claim 1, wherein R 1 is R 1 -Z ² -, wherein Z ² is C (= O) and R ² is optionally substituted aryl, optionally substituted heteroaryl or optionally substituted arylalkyl. O The compound of claim 2, wherein R is phenyl or phenyl substituted with one or two aryloxy, cyano, halogens, lower alkoxy, lower alkyl, nitro or CF 8. The compound of claim 2, wherein R is isoquinolinyl, isoxazolyl, pyrazolopyrimidinyl, pyridyl, pyrimidinyl, quinolinyl, thiazolyl and triazolyl, each of which may be optionally substituted with one or two groups selected from alkylcarbonyl, aryl, cyano, halogens, lower alkoxy, lower alkyl, lower alkylsulfonyl, lower alkylthio, nitro and CF. and A compound according to claim 2, wherein R is a benzyl group optionally substituted on the phenyl ring by one or two groups selected from the group consisting of halogens, hydroxy and methoxy groups. The compound of claim 2, wherein R is 2-chlorophenyl, 5-chloro-2-cyanophenyl, 2-chloro-6-methylphenyl, 2,6-dichlorophenyl, and the like. 9 9 9 999 99 999 312, 2,6-difluorophenyl, 4-fluoro-2-trifluoromethyl, 2-methyl-4-nitrophenyl, 2-methyl-5-nitrophenyl, 2-nitrophenyl, 3-nitrophenyl or 2-phenoxyphenyl. A compound according to claim 1, wherein R ¹ represents a group R ³ -L ³ -Ar ¹ -L ⁴ -Z ³ - in which Z ³ represents a group C (= O), L ⁴ represents an alkylene group consisting of a 1-6 carbon atoms, straight or branched chain * · · Ar represents an optionally substituted phenylene or optionally substituted heteroaryldiyl 3 groups, means the group -NH-C (= O) -NH-, and R represents optionally substituted aryl or optionally substituted heteroaryl. The compound of claim 7, wherein L ⁴ is a methylene group, Ar ¹ is an optionally substituted p-phenylene group, and R is an optionally substituted phenyl group. A compound according to claim 8, wherein Ar 1 'represents a p-phenylene group or a p-phenylene group substituted in the 3-position by halogen, an alkyl group having 1 to 4 carbon atoms, an alkoxy group containing (C 1 -C 4) alkyl, (C 1 -C 4) alkylthio, (C 1 -C 4) alkylsulfinyl, or (C 1 -C 4) alkylsulfonyl, and R is phenyl substituted at the 2-position with (C 1 -C 4) alkyl carbon atoms. 313 A compound according to claim 1, wherein R ¹ represents a group R ¹ -L 2 -Ar 2 -L 2 -Z 2 -, in which O Z ^J is C (= O), a straight or branched chain alkylene group having 1 to 6 carbon atoms, Ar is an optionally substituted 8 to 10 membered bicyclic system in which: a ring means a 5- or 6-membered heterocycle or benzene ring, a ring is a 5- or 6-membered heterocycle or benzene ring, the two rings being joined together by a carbon-carbon or carbon-nitrogen bond, L is NH and O R is an optionally substituted aryl group. • · 314 The compound of claim 10, wherein L ⁴ is a methylene group and Ar 1 is an optionally substituted benzoxazolyl group or an optionally substituted benzimidazolyl group. A compound according to claim 11, wherein Ar ¹ is benzoxazolyl or benzimidazolyl, each of which is optionally substituted with one or more groups selected from the group consisting of lower alkyl, lower alkoxy, amino, halogens, hydroxy, lower alkylthio groups, lower alkylsulfinyl groups, lower alkylsulfonyl groups And R represents a phenyl group substituted in the 2-position by lower alkyl, lower alkoxy, halogen or a (C 1 -C 4) dialkylamino group in each alkyl moiety. The compound of claim 1, wherein R ⁴ is -2 α ϊ Λ * 1 and a group R -L -Ar -L -Z - in which Z represents a group C (= O), L ⁴ represents a straight-chain or branched alkylene group having 1 to 6 carbon atoms, Ar ^ represents an optionally substituted phenylene group or optionally a substituted heteroaryldiyl, ^LJ represents a -C (= O) -NH- group and R represents a heterocycloalkyl group. The compound of claim 13, wherein L ⁴ is a methylene group and Ar 1 is an optionally substituted p-phenylene group. 315 A compound according to claim 14, wherein Ar ¹ is a p-phenylene group or a p-phenylene group substituted at the 3-position by halogen, a C 1 -C 4 alkyl group, an alkoxy group C 1 -C 4 alkyl, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfinyl, or C 1 -C 4 alkylsulfonyl, and R is indolinyl. A compound according to any one of the preceding claims, wherein R is hydrogen. A compound according to any one of the preceding claims, wherein A ¹ is a straight chain unsubstituted alkylene group having 2 to 3 carbon atoms. The compound of claim 17, wherein A ¹ is an ethylene group. A compound according to any one of the preceding claims, wherein Z ¹ is an oxygen atom. A compound according to any one of the preceding claims 1 to 18, wherein Z ¹ is NH. A compound according to any one of the preceding claims 1 to 18 wherein Z ¹ is NC (= O) R ⁹ (wherein R ⁹ is optionally substituted phenyl, C 1 -C 4 alkyl, C 1 -C 4 alkyl) 4 carbon atoms substituted with an acidic group or an alkyl group having 2 to 4 carbon atoms substituted with a group -NY ⁴ Y ³ in which Y ⁴ and Y ³ have the same meaning as defined in claim 1). 316 A compound according to any one of the preceding claims 1 to 18, wherein Z ⁴ is NC (= O) OR ⁴⁴ (wherein R ⁴⁴ is alkyl). A compound according to any one of the preceding claims wherein L ⁴ is an optionally substituted alkylene group. The compound of claim 23, wherein L ⁴ is an ethylene group or a propylene group, each optionally substituted with a lower alkyl group, an aryl group, a heteroaryl group, -N (R 0) -C (= O) -R 3, -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -ny ⁴ y ^5, and - [C (= O) -N (R ⁴⁰ ) -C (r5) (R ¹¹ )] pC (= O) -ΝΥ ⁴ γ ⁵ or an alkyl substituted with a carboxy group (or an acidic bioisoster), -ZH, -ZR ⁴⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ (wherein R 6, R ⁸ , R ⁹ , R ⁴⁹ , R ⁴⁴ , R ⁴⁴ , Y ⁴ , Y ⁴ , Z and p have the same meaning as in claim 1). The compound of claim 23, wherein L ⁴ is a group R ⁵ f -C-CHoI R ⁴⁵ in which: R @ 5 is hydrogen or lower alkyl, and ^IJ R is hydrogen or lower alkyl, <1 s or R is hydrogen and R is aryl, OQ, heteroaryl, -N (R 0) -C (= O) -R, -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -NY ⁴ Y ⁵ , 317 - [C (= O) -N (R ⁴⁰ ) -C (r ⁵ ) (R ⁴⁴ )] p C (= O) -ΝΥ ⁴ γ ⁵ or is an alkyl group substituted with a carboxy group or an acidic bioisoster, or -ZH, -ZR ⁴⁴ , -C (= O) -NY ⁴ Y $ or -NY ⁴ Y ⁵ (in which R ⁵ , R ⁸ , R ⁹ , R ⁴⁰ , R ⁴⁴ , R ⁴⁴ , Υ ⁴ , Y ⁵ , Z and p have the same meaning as in claim 1). The compound of claim 25, wherein L ⁴ is a group R ⁴⁵ in which: R ⁴ represents a hydrogen atom, lower alkyl, aryl, heteroaryl, -N ^(R8) -C (= O) ^-R9, -N ^(R8) -C (= O) -OR ^9, -N (R ⁸ ) -SO ₂ -R ⁹ or -NY ⁴ Y ⁸ or a carboxy-substituted alkyl group, -OH, -OR ⁴⁴ or -C (= O) -NY ⁴ Y ⁴ (wherein R ⁸ , R ⁸⁾ R ⁴⁴ , Y ⁴ and Y ⁴ have the same meaning as in claim 1). The compound of claim 25, wherein L ⁴ is a group H-CH ₂ - in which: R ⁴ represents a hydrogen atom, lower alkyl, aryl, heteroaryl, -N ^(R8) -C (= O) ^-R9, -N ^(R8) -C (= O) -OR ^9, -N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ⁴ γ ⁵ or an alkyl group substituted with a carboxy group, -OH, -OR ⁴⁴ or -C (= O) -NY ⁴ Y ^ (in which • »♦ ·· · ·· ·· · · · · 318 R ⁸ , R ⁹ , R ¹⁴ , Y ⁴ and Y ³ have the same meaning as in claim 1). -i, The compound of claim 23, wherein L is a group R ⁵ I — c — ch ₉ I R ^15a in which: R ³ is hydrogen or lower alkyl, and R _{15a is} lower alkyl, or R ³ is hydrogen and R ^3a is aryl OQ, heteroaryl, -N (R 0) -C (= O) -R, -N (R ⁸ ) -C (= O) -OR ⁹ , -n (r ⁸ ) -so ₂ -r ⁹ , -NY ⁴ Y ⁵ , - [C (= O) -N (r ¹⁰ ) -C (R ³ ) (rH)] -C (= O) -NY ⁴ Y ⁵ or is Kar an alkyl group substituted with a carboxy group or an acidic bioisoster, or -ZH, -ZR ⁴⁴ , -C (= O) -NY ⁴ Y ³ or -NY ⁴ Y ⁵ (in which R ⁵ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹⁴ , Y ⁴ , Y ⁵ Z and p have the same meaning as in claim 1). The compound of claim 28, wherein L ⁴ is a group H ₂ —CH— R ^15a in which: R ^43a is -N (R ⁸ ) -C (= O) -R ⁹ or -N (R ⁸ ) -SO ₂ -R ⁹ (wherein R ⁸ and R ⁹ have the same meaning as in claim 1). ♦ φ · · · · · · 319 φφφ φφ φφ φφφ φφ φ 30. A compound according to claim 28 wherein it represents a group in which: Rl5a _known on _the group -N ^(R8) -C (= 0) -R ⁹ or -N (R ⁸⁾ -SO ₂ -R ⁹ (wherein R ⁸ and R ⁹ are as defined in claim 1). A compound according to any one wherein Y is carboxy. from the preceding claims, A compound according to claim 1 having the general formula (Ia): R ³ -NH-C (= O) -MH-Ar ¹ -? (Ia) wherein R 1, R 1, A ⁴ , Ar ⁴ , L ⁴ , L ⁴ , Y and Z ^{4 have the} same meaning as defined above in the corresponding claims, and pharmaceutically acceptable salts and solvates (such as hydrates) of these compounds and their N-oxides and prodrugs. ³³ A compound according to claim 1 having the general formula (Ib): 320 in which: R ² , R 2, A ¹ , L ² , Y and Z ¹ have the same meaning as defined in the corresponding claims above, X is NR ⁵ or O, Z ⁴ is a direct bond, NR ⁵ , O or S (O) _n (wherein R ⁵ and _n have the same meaning as previously defined), and R represents a hydrogen atom or a substituent of an aryl group, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates thereof, and N-oxides and prodrugs thereof. formula (Ic) A compound according to claim 1 having (Ic) wherein Ar ¹ , L ⁴ , A ¹ , R ² , L ¹ , Y and Z ¹ have the same meaning as defined above in the corresponding claims, and the corresponding N-oxides and their prodrugs, and pharmaceutically acceptable salts and solvates of these compounds. 321 and their N-oxides and prodrugs. A compound according to claim 1 having the general formula (Id): Wherein R, A ^x , R, L ^x Y and Z ^{x have the} same meaning as previously defined, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates of these compounds and their N- oxides and prodrugs. and The compound of claim 32, wherein R is phenyl substituted at the 2-position with C 1 -C 4 alkyl. A compound according to any one of claims 32, 34 and 36, wherein Ar ¹ is a p-phenylene group or a p-phenylene group substituted in the 3-position by halogen, a C 1 -C 4 alkyl group, a C 1 -C 4 alkoxy group, (C 1 -C 4) alkylthio, (C 1 -C 4) alkylsulfinyl, or (C 1 -C 4) alkylsulfonyl group; O A compound according to claim 33, wherein R is a phenyl group substituted in the 2-position by a lower alkyl group. 322, lower alkoxy, halogen, or dialkylamino having 1 to 4 carbon atoms in each alkyl moiety. The compound of claim 33 or 38, wherein Z ⁴ is NH. A compound according to any one of claims 33, 38 and 39, wherein R is hydrogen, halogen, lower alkyl or lower alkoxy. A compound according to any one of claims 32, 33, 34 and 36 to 40, wherein L ⁴ is a straight or branched chain alkylene group having 1 to 4 carbon atoms. The compound of claim 41, wherein L ⁴ is a methylene group. The compound of claim 35, wherein R is phenyl or phenyl substituted with one or two aryloxy, cyano, halogens, lower alkoxy, lower alkyl, nitro or CF ₃ . and A compound according to claim 35, wherein R is a benzyl group optionally substituted on the phenyl ring with one or two halogens, hydroxy or methoxy groups. _z o The compound of claim 35, wherein R is 2-chlorophenyl, 5-chloro-2-cyanophenyl, 2-chloro-6-methylphenyl, 2,6-dichlorophenyl 323 • · · · 4 ·· «• 4 4 4 9 · 44 4 4 44 9 99 4 9 9 9 4 9 4 4 4 4 4 4 4 9 4 5 4 4 4 4 9 4 9 4 494 49 49 ··· 44 ···, 2,6-difluorophenyl, 4-fluoro-2-trifluoromethyl, 2-methyl-4-nitrophenyl, 2-methyl-5-nitrophenyl, 2-nitrophenyl, 3-nitrophenyl or 2-phenoxyphenyl. A compound according to any one of claims 32 to 45, wherein it is an unsubstituted alkylene group having 2 to 3 straight-chain carbon atoms. The compound of claim 46, wherein A 1 is an ethylene group. A compound according to any one of claims 32 to 47, wherein Z ¹ is an oxygen atom. A compound according to any one of claims 32 to 37, wherein Z 2 is NH. A compound according to any one of claims 32 to 47, wherein Z 1 is NC (= O) R 1 (wherein R 1 is optionally substituted phenyl, C 1 -C 4 alkyl, C 1 -C 4 alkyl) 4 carbon atoms substituted with an acidic group or an alkyl group having 2 to 4 carbon atoms substituted with a -NY ⁴ Y ⁵ group in which Y ⁴ and Y ⁵ have the same meaning as defined in claim 1). A compound according to any one of claims 32 to 47, wherein Z ¹ is NC (= O) OR ¹⁴ (wherein R ¹⁴ is alkyl). A compound according to any one of claims 32 to 51, v 324 * which R represents a hydrogen atom. A compound according to any one of claims 32 to 52, wherein L ¹ is an optionally substituted alkylene group. The compound of claim 53, wherein L ¹ is an ethylene group or a propylene group, each optionally substituted with a lower alkyl group, an aryl group, a heteroaryl group, -N (R) -C (= O) -R 3, -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -ny ⁴ y ^5, and - [C (= O) -N (R ¹⁰ ) -C (R ⁵ ) (R ¹¹ )] -C (= O) -NY ⁴ Y ⁵ or alkyl Jr substituted with carboxy (or an acidic bioisoster), -ZH, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or -NY ⁴ Y ⁵ (wherein R ⁵ , R ⁸ , R ⁹ , R ¹⁰ , R ⁹ ) ¹¹ , R ¹⁴ , Y ⁴ , Y ⁵ , Z and p have the same meaning as in claim 1). The compound of claim 53, wherein L ¹ is a group wherein: R ³ is hydrogen or lower alkyl, and R ¹³ is hydrogen or lower alkyl; or R ^J is hydrogen and R is aryl, OQ, heteroaryl, -N (R 0) -C (= O) -R, -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ , -y ⁴ y ⁵ , - [C (= O) -N (R ¹⁹ ) -C (R ³ ) (R ¹¹ )] -C (= O) -NY ⁴ Y ⁵ or represents an alkyl group substituted with a carboxy group or an acidic bioisoster, or -ZH groups, -ZR ¹⁴ , -C (= O) -NY ⁴ Y ³ or 325 • 4 4 · 9 9 4 9 9 4 9 9 9 9 9 4 4 4 4 9 9 9 4 • -NY ⁴ Y ⁵ (in which R ⁵ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹⁴ , Y ⁴ , Y ⁵ , Z and p have the same meaning as in claim 1). The compound of claim 55, wherein L ¹ is a group H — CH in which: R ¹³ is hydrogen, lower alkyl, aryl, heteroaryl, -N ^(R8) -C (= O) ^-R9, -N ^(R8) -C (= O) -OR ^9, - N (R ⁸ ) -SO ₂ -R ⁹ or -NY ⁴ Y ³ or a carboxy-substituted alkyl group, -OH, -OR ¹⁴ or -C (= O) -NY ⁴ Y ³ (wherein R ⁸ , R ⁸ , R ¹⁴ , Y ⁴ and Y ⁵ have the same meaning as in claim 1). The compound of claim 55, wherein L ¹ is a group -CH — CH ₀ - i R ¹⁵ in which: R ¹³ is hydrogen, lower alkyl, aryl, heteroaryl, -N ^(R8) -C (= O) ^-R9, -N ^(R8) -C (= O) -OR ^9, - N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ^{4 5 5} or an alkyl group substituted with a carboxy group, -OH, -OR ¹⁴ or -C (= O) -NY ⁴ Y ³ (wherein R ⁸ , R ⁹ , R ⁹ ) ¹⁴ , Y ⁴ and Y ³ have the same meaning as in claim 1). The compound of claim 53, wherein L ¹ is a group 326 -C-CH ₉ I R ^ a in which: R @ 5 is hydrogen or lower alkyl, and Rl5a _significance Measured lower alkyl group, or R5 is hydrogen and ^R4 is aryl ^and $ of Q, heteroaryl, -N (R) -C (= O) -R, -N (R ⁸⁾ -C ( = O) -OR ⁹ , -n (r ⁸ ) -so ₂ -r ⁹ , -n ⁴ y ⁵ , - [C (= O) -N (R 6) - C (R ⁵ ) (R ¹¹ )] -C (= O) -NY ⁴ Y ⁵ or is an alkyl group substituted with a carboxy group or an acidic bioisoster, or -ZH, - ZR ^ ⁴ , -C (= O) -NY ⁴ Y ^ or -NY ⁴ Y ⁵ (in which R ⁵ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹⁴ , Υ ⁴ , Y ⁵ , Z and p have the same meaning as in claim 1). The compound of claim 58, wherein L ¹ is a group H ₂ —CH— R ^15a in which: R15a. is -N (R ⁸⁾ -C (= 0) -R ⁹ or -N (R ⁸⁾ -SO ₂ -R ⁹ (wherein R ⁸ and R ⁹ are as defined in claim 1). The compound of claim 58, wherein L ¹ is a group -CH ₉ —CH— * 15a 327 in which: Rl5a _is the group -N (R ⁸⁾ -C (= 0) -R ⁹ or -N (R ⁸⁾ -SO ₂ -R ⁹ (wherein R ⁸ and R ⁹ are as defined in claim 1). A compound according to any one of the preceding claims wherein Y is carboxy. A compound of formula (Ia) according to claim 32, wherein: O R is hydrogen, R ³ represents a 2-substituted phenyl group, is ethylene, Ar ⁴ represents an optionally substituted m-phenylene or p-phenylene group or an optionally substituted p-pyridinediyl group; -CH-CH ₂ - Ø ¹⁵ [wherein R ⁴³ represents hydrogen, lower alkyl, aryl, heteroaryl, -N ^(R8) -C (= O) ^-R9, -N ^(R8) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ⁴ γ ⁵ or an alkyl group substituted with a carboxy group (or an acidic bioisoster), -OH, -OR ^4, or -C (= O) -NY ⁴ Y $], L ⁴ represents a straight or branched chain alkylene group having 1 to 6 carbon atoms, Y is carboxy, and is oxygen, NH, NC (= O) R ⁹ (wherein R ⁹ is phenyl, C 1 -C 4 alkyl, C 1 -C 4 alkyl) 328 ♦ · ·· • · · · • * 9 • 9 9 t «· 4 · Φ · 4 9 4 4 8 • · 9 · · · 9 93 4 4 • 4 substituted with COOH or C 2-4 alkyl substituted with -NY ⁴ Y ³ wherein Y ⁴ and Y ³ are both C 1-4 alkyl) or NC (= O) OR ¹⁴ (where R ¹⁴ represents an alkyl group having 1 to 6 carbon atoms, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates thereof, and N-oxides and prodrugs thereof. A compound of formula (Ia) according to claim 32, wherein: R ² is hydrogen, R ³ represents a 2-substituted phenyl group, A is ethylene, Ar 1 represents an optionally substituted m-phenylene or p-phenylene group or an optionally substituted p-pyridinediyl group, iA represents a group -CH ₉ —CH— AND ^R13 [in which R ^3a represents a group -N (R ⁸⁾ -C (= 0) -R ⁹ or -N (R ⁸ ) -SO ₂ -R ⁹ ], L ⁴ represents a straight or branched chain alkylene group having 1 to 6 carbon atoms, Y is carboxy, and Z ¹ is oxygen, NH, NC (= O) R ⁹ (wherein R ⁹ is phenyl, C 1 -C 4 alkyl, C 1 -C 4 alkyl substituted with COOH, or C 2 -C 4 alkyl) carbon substituted by -NY ⁴ Y ³ , wherein Y ⁴ and Y ³ are both alkyl 329 ··· (1 to 4 carbon atoms) or NC (= O) OR ⁴⁴ (where R ⁴⁴ represents an alkyl group containing 1 to 6 carbon atoms), and the corresponding N- oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates thereof and N-oxides and prodrugs thereof. A compound of formula (Ib) according to claim 33, wherein: R represents a hydrogen atom, a chlorine atom, a methyl group, an ethyl group or a methoxy group, O R is hydrogen, R represents a substituted aryl group, A ⁴ is ethylene, L ⁴ represents a group H — CH ₂ - [wherein R ⁴ is hydrogen, lower alkyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -ΝΥ ⁴ γ ⁵ or an alkyl group substituted with a carboxy group (or an acidic bioisoster), -OH, -ZR ⁴⁴ , -C (= O) - NY ⁴ Y ^ or -NY ⁴ Y ⁵ ], L ⁴ represents a straight or branched chain alkylene group having 1 to 4 carbon atoms, X is 0, Y is carboxy, and Z ⁴ is oxygen, NH, NC (= O) R ⁹ (where R ⁹ is phenyl, C 1 -C 4 alkyl, C 4 -C 4 alkyl substituted with COOH, or C 2 -C 4 alkyl carbon substituted by a group 330 · · 9 9 · 9 9 9 9 -NY ⁴ Y ⁵ in which Y ⁴ and Y ⁵ are both C 1 -C 4 alkyl) or NC (= O) OR ¹⁴ (where R ¹⁴ is C 1 -C 6 alkyl), and is attached to the 6-position of the ring, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates of these compounds and their N-oxides and prodrugs. A compound of formula (Ib) according to claim 33, wherein: R represents a hydrogen atom, a chlorine atom, a methyl group, an ethyl group or a methoxy group, R is hydrogen, R ³ is an optionally substituted group, A ¹ is ethylene, L ¹ represents a group -CH _O —CH— Wherein R ^15a is -N (R ⁸ ) -C (= O) -R ⁹ or -N (R ⁸ ) -SO ₂ -R ⁹ ], L ⁴ represents a straight or branched chain alkylene group having 1 to 4 carbon atoms, Y is carboxy, and Z ¹ is oxygen, NH, NC (= O) R ⁹ (where R ⁹ is a 331 ·· · 9 9 · · * 9 9 9 9 9 999 ·· 99999 9 9 999 * phenyl, C1-C4alkyl, C1-C4alkyl; 1 to 4 carbon atoms substituted by COOH or alkyl containing 2-4 carbon atoms substituted by -NY ⁴ Y ^2, Y ⁴ and Y ² are both alkyl containing 1 to 4 carbon atoms) or NC (= O) OR ⁴⁴ (wherein R ⁴⁴ represents an alkyl group having 1 to 6 carbon atoms), Z ⁴ is NH, and the group is attached to the 6-position of the ring, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates of these compounds, and N-oxides and prodrugs thereof. A compound of formula (Ib) according to claim 33, wherein: R ² is hydrogen, R ² represents an optionally substituted aryl group, A ⁴ is ethylene, L ⁴ represents a group -CH — CH ₉ - AND R ⁴⁵ [wherein R ⁴² represents a hydrogen atom, a lower alkyl group, an aryl group, a heteroaryl group, a group i: ♦ ♦ 9 332 -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -NY ⁴ Y ⁵ or an alkyl group substituted with a carboxy group (or an acidic bioisoster), -OH, -OR ¹⁴ , -C (= O) -NY ⁴ Y ⁵ or _NY ⁴ Y ⁵ ], L ⁴ represents a straight or branched chain alkylene group having 1 to 4 carbon atoms, X is NR ^5, Y is carboxy, Z ¹ is oxygen, NH, NC (= O) R ⁹ (wherein R ⁹ is phenyl, C 1 -C 4 alkyl, C 1 -C 4 alkyl substituted with COOH, or C 2 -C 4 alkyl) carbon substituted by -NY ⁴ Y ⁵ , wherein Y ⁴ and Y ⁵ are both C 1 -C 4 alkyl) or NC (= O) OR ¹⁴ (where R ¹⁴ is C 1 -C 6 alkyl) , Z ⁴ is NH, and the group is attached to the 5 or 6 position of the ring, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates of these compounds, and N-oxides and prodrugs thereof. A compound of formula (1b) according to claim 33, wherein: R ² is hydrogen, R ³ is an optionally substituted group, 333 A ⁴ is ethylene, L ⁴ represents a group -CH ~ —CH— I ^ 5 [where R @ ⁴ represents ^a group -N ^(R8) -C (= 0) -R ⁹ or -N (R ⁸ ) -SO ₂ -R ⁹ ], L ⁴ represents a straight or branched chain alkylene group having 1 to 4 carbon atoms, X is NR6 Y is carboxy, and Z ⁴ is oxygen, NH, NC (= O) R ⁹ (wherein R ⁹ is phenyl, C 1 -C 4 alkyl, C 4 -C 4 alkyl substituted with COOH, or C 2 -C 4 alkyl carbon atoms substituted with a group -ΝΥ ⁴ γ5 in which Y ⁴ a represents both C 1 -C 4 alkyl) or NC (= O) OR ⁴⁴ (where R ⁴⁴ represents C 1 -C 6 alkyl), Z ⁴ is NH, and the group is attached to the 5 or 6 position of the ring, and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates of these compounds, and N-oxides and prodrugs thereof. 334 • · 4 4 · · · 44 · 4 4 4 • 44 44 4 · 44 44 44 · 44 A compound of formula (Ic) according to claim 34, wherein: O R is hydrogen, A ¹ is ethylene, Ar ¹ represents an optionally substituted m-phenylene or p-phenylene group or an optionally substituted p-pyridinediyl group, L ¹ represents a group _-CH-O - I r! 5 [where R ¹³ represents hydrogen, methyl, aryl, heteroaryl, -N ^(R8) -C (= O) ^-R9, -N ^(R8) -C (= O -OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -NY ⁴ Y ³ or a carboxy-substituted alkyl group, -OH, -OR ³ or -C (= O) -NY ⁴ Y ³ ], L ⁴ represents a straight or branched chain alkylene group having 1 to 4 carbon atoms, Y is carboxy, and Z ¹ is oxygen, NH, NC (= O) R ⁹ (wherein R ⁹ is phenyl, C 1 -C 4 alkyl, C 1 -C 4 alkyl substituted with COOH, or C 2 -C 4 alkyl) carbon substituted by -NY ⁴ Y ³ , wherein Y ⁴ and Y ³ are both C 1 -C 4 alkyl) or NC (= O) OR ¹⁴ (where R ¹⁴ is C 1 -C 6 alkyl), and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates thereof and N-oxides and prodrugs thereof. A compound of formula (Ic) according to claim 34, 335 in which: R is hydrogen, A · * - is ethylene, Ar 1 is an optionally substituted m-phenylene or p-phenylene group or an optionally substituted p-pyridinediyl group, L ¹ represents a group -CH ₉ —CH— P15a [in which R ³ - represents a group -N (R ⁸ ) -C (= O) -R ⁹ or -N (R ⁸ ) -SO ₂ -R ⁹ ], L ⁴ represents a straight or branched chain alkylene group having 1 to 4 carbon atoms, Y is carboxy, and Z- * · represents oxygen, NH, NC (= O) R ⁹ (wherein R ⁹ represents phenyl, C 1 -C 4 alkyl, C 4 -C 4 alkyl substituted with COOH or C 2 -C 4 alkyl) C4alkyl substituted with -ΝΥ γ5 ^4, Y ⁴ and Y ^ are both alkyl containing 1 to 4 carbon atoms) or NC (= 0) 0R @ ⁴ (wherein R ⁴ represents an alkyl radical containing from 1 to 6 carbon atoms), and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates thereof, and N-oxides and prodrugs thereof. A compound of formula (Id) according to claim 35, wherein: R is hydrogen, R ⁸ represents optionally substituted phenyl, optionally substituted heteroaryl or optionally • · 9 «« «· φ Φ * · * · · · Φ Φ Φ φ ΦΦ * · · · · · •• ♦ •• Φ Φφφ • ΦΦ ΦΦ ΦΦ · Φ · Φφ ΦΦφ 336 substituted benzyl, A ⁴ is ethylene, L ⁴ represents a group -CH — CH _? - AND R ⁴⁵ [wherein R ⁴³ is hydrogen, methyl, aryl, heteroaryl, -N (R ⁸ ) -C (= O) -R ⁹ , -N (R ⁸ ) -C (= O) - OR ⁹ , -N (R ⁸ ) -SO ₂ -R ⁹ or -NY ⁴ Y ³ or a carboxy-substituted alkyl group, -OH, -OR ⁴⁴ or -C (= O) -NY ⁴ Y ³ ], Y is carboxy, and Z ⁴ is oxygen, NH, NC (= O) R ⁹ (wherein R ⁹ is phenyl, C 1 -C 4 alkyl, C 4 -C 4 alkyl substituted with COOH, or C 2 -C 4 alkyl) carbon substituted by -NY ⁴ Y ³ in which Y ⁴ and Y ³ are both C 1 -C 4 alkyl) or NC (= O) OR ⁴⁴ (where R ⁴⁴ is C 1 -C 6 alkyl) , and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates thereof, and N-oxides and prodrugs thereof. A compound of formula (Id) according to claim 35, wherein: O R is hydrogen, R ³ represents an optionally substituted phenyl group, an optionally substituted heteroaryl group, or an optionally substituted benzyl group, A ⁴ is ethylene, L ⁴ represents a group 337 ··. 9 ♦ 9 9 9 • ·· 9 9 9 9 9 9 9 Wherein R @ ^13a is --N (R @ ⁸ ) --C (.dbd.O) - R @ ⁹ or -N (R ⁸ ) -SO ₂ -R ⁹ ], Y is carboxy, and Z is oxygen, NH, NC (= O) R ⁹ (wherein R ⁹ is phenyl, C 1 -C 4 alkyl, C 4 -C 4 alkyl substituted with COOH or C 2 -C 4 alkyl) carbon atoms substituted with -NY ⁴ Y ³ , wherein Y ⁴ and Y ³ are both C 1 -C 4 alkyl) or NC (= O) OR ¹⁴ (where R · ¹ · ⁴ is C 1 -C 4 alkyl) and the corresponding N-oxides and prodrugs thereof, and pharmaceutically acceptable salts and solvates thereof and N-oxides and prodrugs thereof. according to any one of claims 63, 65, 67, is a group 72. Compound 69 and 71 wherein ΐΛ: h ₉ —CH— I _R 15a A compound according to any one of claims 64, 66, 68, and 70, wherein L ¹ is a group -CH ₉ —CH— R ^15a 338 A compound according to claim 73, wherein R ¹³ is hydrogen. A compound according to claim 73, wherein R ¹³ is lower alkyl. The compound of claim 73, wherein R ³ is an optionally substituted phenyl group. The compound of claim 73, wherein R ³ is Q Q Q -N (R °) -C (= O) -R wherein R is hydrogen or lower alkyl and R ⁹ is lower alkyl, aryl, heteroaryl, alkoxy substituted alkyl, carboxy substituted alkyl or alkyl a group substituted with -NY ⁴ Y ³ . A compound according to claim 73, wherein R ⁴³ is -N (R ⁸ ) -C (= O) -OR ⁹ , wherein R ⁸ represents a hydrogen atom or a lower alkyl group and R ⁹ represents a lower alkyl group or an alkyl group substituted with aryl group. A compound according to claim 73 wherein R ³ is it -N (R 0) -SO ₂ -R ¹ 'in which R represents a hydrogen atom or a lower alkyl group and R ⁹ represents a lower alkyl group, an aryl group or a heteroaryl group. A compound according to claim 73, wherein R ³ is -NY ⁴ Y ³ , wherein Y ⁴ and Y ³ are hydrogen. A compound according to claim 73, wherein R ³ is -NY ⁴ Y ³ , wherein Y ⁴ is hydrogen and Y ³ is lower alkyl or substituted alkyl. 339 with an aryl group. The compound of claim 73, wherein -NY ^{4 is} Y ³ , wherein Y ⁴ and Y ^{3 are} both aryl. 83. A compound according to claim 73 wherein R1 is lower alkyl substituted by carboxy. 1 sec A compound according to claim 73, wherein R is a lower alkyl group substituted with -OH. 85. A compound according to claim 73, wherein R ¹³ represents a lower alkyl group substituted by -OR ^ ^4th The compound of claim 73, wherein R 1 is a lower alkyl group substituted with -C (= O) -NY ⁴ Y ⁵ . A compound according to claim 73, wherein R 1 is -H, -NH ₂ , 340 II φ ο II -23Η — C-CHt-N Ο ο II / ', - CH — C — ρ ρ, -CH-C-Ν Ν-Me \ _ / __ ν / // (wherein R is hydrogen or an aryl group substituent), -CH _3, -CH ₂ CH _3, -CH ₂ CH ₂ CH _3, -CH ₂ ch ₂ ch ₂ ch ₃ , —CH ₂ —CO ₂ H or —CH ₂ —OMe —CH ₂ —OH • · 341 • · 88. A compound according to claim 72, wherein R ^^ ^and represents -N (R8) -C (= 0) -R, in which R® is hydrogen or lower alkyl and R represents lower alkyl, aryl , heteroaryl, alkyl substituted with alkoxy, alkyl substituted with carboxy or alkyl substituted with -NY ⁴ Y ⁴ . 89. The compound of claim 72, wherein R ^^ ^and represents -N (R8) -C (= 0) -R, in which R® is hydrogen or lower alkyl and R is selected from the group consisting of 2-chlorophenyl, 5-chloro-2-cyanophenyl, 2-chloro-6-methylphenyl, 2,6-dichlorophenyl, 2,6-difluorophenyl, 4-fluoro-2-1-trifluoromethyl group, 2-methyl-4-nitrophenyl, 2-methyl-5-nitrophenyl, 2-nitrophenyl, 3-nitrophenyl and 2-phenoxyphenyl. 90. The compound of claim 72 in which R ^^ ^and represents -N (R8) -C (= 0) -R, in which R® is hydrogen or lower alkyl and R is selected from the group consisting of quinoline 4-yl, isoquinolin-2-yl, 2,4-pyridin-3-yl, 2,6-dimethyl-4-trifluoromethylpyridin-3-yl; A 4-trifluoromethylpyridin-3-yl group, A 2-phenyl-4-methyl-1,2,3-triazol-5-yl group, 3,5-dimethylisoxazol-4-yl; A 2,7-dimethylpyrazolo [1,5-a] pyrimidin-6-yl group, A 2-isopropyl-4-methylthiazol-5-yl group and a 4-trifluoromethylpyrimidin-5-yl group. 91. A pharmaceutical composition comprising: 342 comprises an effective amount of a compound of claim 1 or a corresponding N-oxide or prodrug thereof, or a pharmaceutically acceptable salt or solvate thereof, or an N-oxide or prodrug thereof, in association with a pharmaceutically acceptable carrier or excipient. A compound according to claim 1 or a corresponding N-oxide or prodrug thereof, or a pharmaceutically acceptable salt or solvate thereof, or an N-oxide or prodrug thereof, for use in therapy. 93. A compound according to claim 1 or a corresponding N-oxide or prodrug thereof, or a pharmaceutically acceptable salt or solvate thereof, or an N-oxide or prodrug thereof, for use in treating a patient suffering from or susceptible to a disease state that may be attenuated by administration of α4β1-mediated cell adhesion inhibitor. The pharmaceutical composition of claim 91 for use in treating a patient suffering from or susceptible to a disease state that can be alleviated by administration of an α4β1 mediated cell adhesion inhibitor. The compound or composition of claim 1 or 91 for use in the treatment of inflammatory diseases. The compound or composition of claim 1 or 91 for use in treating asthma. 97. The use of a compound according to claim 1 or a corresponding N-oxide or prodrug thereof 343 a compound, or a pharmaceutically acceptable salt or solvate thereof, or an N-oxide or prodrug thereof, for use in the manufacture of a medicament for treating a patient suffering from or susceptible to a disease state which can be alleviated by administration of α4β1-mediated cell adhesion inhibitor. 98. The use of a compound according to claim 1 or a corresponding N-oxide or prodrug thereof, or a pharmaceutically acceptable salt or solvate thereof, or an N-oxide or prodrug thereof, for use in the manufacture of a medicament for treating asthma. 99. A method of treating a human individual or a non-human individual suffering from or susceptible to a disease state which may be alleviated by administering an α4β1 mediated cell adhesion inhibitor comprising administering to said patient an effective amount of a compound of claim 1 or a corresponding N-oxide or prodrug thereof, or a pharmaceutically acceptable salt or solvate thereof, or an N-oxide or prodrug thereof. 100. A compound substantially described in this specification with reference to Examples.