CZ2003141A3 - Léčivo pro omezení výskytu a/nebo závažnosti nového vzplanutí nového chorobného procesu COPD - Google Patents
Léčivo pro omezení výskytu a/nebo závažnosti nového vzplanutí nového chorobného procesu COPD Download PDFInfo
- Publication number
- CZ2003141A3 CZ2003141A3 CZ2003141A CZ2003141A CZ2003141A3 CZ 2003141 A3 CZ2003141 A3 CZ 2003141A3 CZ 2003141 A CZ2003141 A CZ 2003141A CZ 2003141 A CZ2003141 A CZ 2003141A CZ 2003141 A3 CZ2003141 A3 CZ 2003141A3
- Authority
- CZ
- Czechia
- Prior art keywords
- copd
- pde4 inhibitor
- ratio
- pde4
- rolipram
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims description 14
- 230000005713 exacerbation Effects 0.000 title abstract description 3
- 238000000034 method Methods 0.000 claims abstract description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 42
- 230000008569 process Effects 0.000 claims description 30
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 29
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims description 21
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims description 20
- 229950005741 rolipram Drugs 0.000 claims description 20
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 claims description 19
- 230000027455 binding Effects 0.000 claims description 13
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- 230000003197 catalytic effect Effects 0.000 claims description 4
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- 229940002612 prodrug Drugs 0.000 claims description 3
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- 150000003839 salts Chemical class 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- HJORMJIFDVBMOB-LBPRGKRZSA-N (-)-rolipram Chemical compound COC1=CC=C([C@H]2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-LBPRGKRZSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- KLPQJJKXRIDASJ-UHFFFAOYSA-N 3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-N-ethyl-8-propan-2-yl-7H-purin-6-imine Chemical compound CCN=C1C2=C(N=C(N2)C(C)C)N(C=N1)CC3=CC(=C(C=C3)OC)OC4CCCC4 KLPQJJKXRIDASJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 abstract description 10
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 abstract 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22127500P | 2000-07-27 | 2000-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ2003141A3 true CZ2003141A3 (cs) | 2004-07-14 |
Family
ID=22827112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ2003141A CZ2003141A3 (cs) | 2000-07-27 | 2001-07-26 | Léčivo pro omezení výskytu a/nebo závažnosti nového vzplanutí nového chorobného procesu COPD |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1320361A4 (pl) |
| JP (1) | JP2004505039A (pl) |
| KR (1) | KR20030019620A (pl) |
| CN (1) | CN1444476A (pl) |
| AR (1) | AR029984A1 (pl) |
| AU (2) | AU2001279023B2 (pl) |
| BR (1) | BR0112682A (pl) |
| CA (1) | CA2417336A1 (pl) |
| CZ (1) | CZ2003141A3 (pl) |
| HU (1) | HUP0300685A3 (pl) |
| IL (1) | IL153919A0 (pl) |
| MX (1) | MXPA03000714A (pl) |
| NO (1) | NO20030332L (pl) |
| PL (1) | PL365612A1 (pl) |
| WO (1) | WO2002009689A1 (pl) |
| ZA (1) | ZA200300476B (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| DE10110772A1 (de) * | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| US7776315B2 (en) | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
| GB0118373D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| DE10230769A1 (de) * | 2002-07-09 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren |
| ES2335498T3 (es) | 2003-03-10 | 2010-03-29 | Nycomed Gmbh | Nuevo proceso para la preparacion de reflumilast. |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| KR102087661B1 (ko) * | 2018-07-27 | 2020-03-11 | 강원대학교산학협력단 | Ｇｅｂｒ―７ｂ 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ3019A1 (fr) * | 1999-03-01 | 2005-05-20 | Smithkline Beecham Corp | Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd. |
| SE9902937D0 (sv) * | 1999-08-18 | 1999-08-18 | Astra Pharma Prod | Pharmaceutical compositions |
| JP2003513038A (ja) * | 1999-10-29 | 2003-04-08 | スミスクライン・ビーチャム・コーポレイション | ホスホジエステラーゼ４阻害剤の投与法 |
-
2001
- 2001-07-25 AR ARP010103546A patent/AR029984A1/es not_active Application Discontinuation
- 2001-07-26 PL PL01365612A patent/PL365612A1/pl not_active Application Discontinuation
- 2001-07-26 JP JP2002515242A patent/JP2004505039A/ja not_active Withdrawn
- 2001-07-26 HU HU0300685A patent/HUP0300685A3/hu unknown
- 2001-07-26 CZ CZ2003141A patent/CZ2003141A3/cs unknown
- 2001-07-26 WO PCT/US2001/023542 patent/WO2002009689A1/en not_active Ceased
- 2001-07-26 AU AU2001279023A patent/AU2001279023B2/en not_active Ceased
- 2001-07-26 CN CN01813330A patent/CN1444476A/zh active Pending
- 2001-07-26 MX MXPA03000714A patent/MXPA03000714A/es unknown
- 2001-07-26 AU AU7902301A patent/AU7902301A/xx active Pending
- 2001-07-26 KR KR10-2003-7001144A patent/KR20030019620A/ko not_active Withdrawn
- 2001-07-26 IL IL15391901A patent/IL153919A0/xx unknown
- 2001-07-26 EP EP01957262A patent/EP1320361A4/en not_active Withdrawn
- 2001-07-26 BR BR0112682-2A patent/BR0112682A/pt not_active IP Right Cessation
- 2001-07-26 CA CA002417336A patent/CA2417336A1/en not_active Abandoned
-
2003
- 2003-01-17 ZA ZA200300476A patent/ZA200300476B/en unknown
- 2003-01-22 NO NO20030332A patent/NO20030332L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR029984A1 (es) | 2003-07-23 |
| KR20030019620A (ko) | 2003-03-06 |
| PL365612A1 (pl) | 2005-01-10 |
| AU2001279023B2 (en) | 2005-11-10 |
| ZA200300476B (en) | 2004-04-23 |
| HUP0300685A3 (en) | 2004-10-28 |
| JP2004505039A (ja) | 2004-02-19 |
| CA2417336A1 (en) | 2002-02-07 |
| NO20030332D0 (no) | 2003-01-22 |
| BR0112682A (pt) | 2003-06-24 |
| MXPA03000714A (es) | 2003-06-04 |
| NO20030332L (no) | 2003-01-22 |
| CN1444476A (zh) | 2003-09-24 |
| AU7902301A (en) | 2002-02-13 |
| EP1320361A1 (en) | 2003-06-25 |
| HUP0300685A2 (hu) | 2003-12-29 |
| EP1320361A4 (en) | 2006-04-05 |
| IL153919A0 (en) | 2003-07-31 |
| WO2002009689A1 (en) | 2002-02-07 |
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