CZ295843B6 - Multi-funkční chimérní agonisté hematopoietických receptorů - Google Patents

Multi-funkční chimérní agonisté hematopoietických receptorů Download PDF

Info

Publication number: CZ295843B6
Authority: CZ; Czechia
Prior art keywords: xaa; leu; seq; ser; arg
Prior art date: 1996-10-25

Application number

CZ19991323A

Other languages

Czech (cs)

English (en)

Other versions

CZ132399A3 (cs

Inventor

Wherter Charles A. Mc

Yiqing Feng

Kearn John P. Mc

Neena L. Summers

Nicholas R. Staten

Philip R. Streeter

John C. Minnerly

Nancy I. Minster

Susan L. Woulfe

Original Assignee

G. D. Searle & Co.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-25

Filing date

1997-10-23

Publication date

2005-11-16

1997-10-23 Application filed by G. D. Searle & Co. filed Critical G. D. Searle & Co.

1999-12-15 Publication of CZ132399A3 publication Critical patent/CZ132399A3/cs

2005-11-16 Publication of CZ295843B6 publication Critical patent/CZ295843B6/cs

Links

230000003394 haemopoietic effect Effects 0.000 title claims abstract 48
239000000018 receptor agonist Substances 0.000 title claims abstract 16
229940044601 receptor agonist Drugs 0.000 title claims abstract 16
108090000623 proteins and genes Proteins 0.000 claims abstract 49
102000004169 proteins and genes Human genes 0.000 claims abstract 46
238000000034 method Methods 0.000 claims abstract 6
102000039446 nucleic acids Human genes 0.000 claims 474
108020004707 nucleic acids Proteins 0.000 claims 474
150000007523 nucleic acids Chemical class 0.000 claims 474
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 249
235000001014 amino acid Nutrition 0.000 claims 228
150000001413 amino acids Chemical class 0.000 claims 218
BUZMZDDKFCSKOT-CIUDSAMLSA-N Glu-Glu-Glu Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O BUZMZDDKFCSKOT-CIUDSAMLSA-N 0.000 claims 139
KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims 108
108010055341 glutamyl-glutamic acid Proteins 0.000 claims 103
XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims 99
108010050848 glycylleucine Proteins 0.000 claims 98
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 87
HDHZCEDPLTVHFZ-GUBZILKMSA-N Asn-Leu-Glu Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O HDHZCEDPLTVHFZ-GUBZILKMSA-N 0.000 claims 70
108010025198 decaglycine Proteins 0.000 claims 48
YOKVEHGYYQEQOP-QWRGUYRKSA-N Leu-Leu-Gly Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O YOKVEHGYYQEQOP-QWRGUYRKSA-N 0.000 claims 46
108010026333 seryl-proline Proteins 0.000 claims 43
235000018102 proteins Nutrition 0.000 claims 42
XCIGOVDXZULBBV-DCAQKATOSA-N Ala-Val-Lys Chemical compound CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(O)=O XCIGOVDXZULBBV-DCAQKATOSA-N 0.000 claims 41
108010002311 N-glycylglutamic acid Proteins 0.000 claims 40
108010001064 glycyl-glycyl-glycyl-glycine Proteins 0.000 claims 39
WZDCVAWMBUNDDY-KBIXCLLPSA-N Ile-Glu-Ala Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O)N WZDCVAWMBUNDDY-KBIXCLLPSA-N 0.000 claims 38
108010091871 leucylmethionine Proteins 0.000 claims 38
101150014526 Gla gene Proteins 0.000 claims 37
SQUTUWHAAWJYES-GUBZILKMSA-N Met-Asp-Arg Chemical compound [H]N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SQUTUWHAAWJYES-GUBZILKMSA-N 0.000 claims 37
125000003275 alpha amino acid group Chemical group 0.000 claims 35
UPLYXVPQLJVWMM-KKUMJFAQSA-N Ser-Phe-Leu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O UPLYXVPQLJVWMM-KKUMJFAQSA-N 0.000 claims 34
YBPLKDWJFYCZSV-ZLUOBGJFSA-N Ala-Asn-Cys Chemical compound C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)O)N YBPLKDWJFYCZSV-ZLUOBGJFSA-N 0.000 claims 33
SENJXOPIZNYLHU-UHFFFAOYSA-N L-leucyl-L-arginine Natural products CC(C)CC(N)C(=O)NC(C(O)=O)CCCN=C(N)N SENJXOPIZNYLHU-UHFFFAOYSA-N 0.000 claims 32
YVKSMSDXKMSIRX-GUBZILKMSA-N Leu-Glu-Asn Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O YVKSMSDXKMSIRX-GUBZILKMSA-N 0.000 claims 32
108010087924 alanylproline Proteins 0.000 claims 32
108010067216 glycyl-glycyl-glycine Proteins 0.000 claims 32
108010000761 leucylarginine Proteins 0.000 claims 32
ZMUQQMGITUJQTI-CIUDSAMLSA-N Asn-Leu-Asn Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O ZMUQQMGITUJQTI-CIUDSAMLSA-N 0.000 claims 31
MMEDVBWCMGRKKC-GARJFASQSA-N Leu-Asp-Pro Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@@H]1C(=O)O)N MMEDVBWCMGRKKC-GARJFASQSA-N 0.000 claims 31
RIAKPZVSNBBNRE-BJDJZHNGSA-N Ser-Ile-Leu Chemical compound OC[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O RIAKPZVSNBBNRE-BJDJZHNGSA-N 0.000 claims 31
SPIPSJXLZVTXJL-ZLUOBGJFSA-N Asn-Cys-Ser Chemical compound NC(=O)C[C@H](N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(O)=O SPIPSJXLZVTXJL-ZLUOBGJFSA-N 0.000 claims 29
XAJRHVUUVUPFQL-ACZMJKKPSA-N Asp-Glu-Asp Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O XAJRHVUUVUPFQL-ACZMJKKPSA-N 0.000 claims 29
-1 His Chemical group 0.000 claims 29
IDAHFEPYTJJZFD-PEFMBERDSA-N Ile-Asp-Glu Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N IDAHFEPYTJJZFD-PEFMBERDSA-N 0.000 claims 29
NWAHPBGBDIFUFD-KKUMJFAQSA-N Asp-Tyr-Leu Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(O)=O NWAHPBGBDIFUFD-KKUMJFAQSA-N 0.000 claims 28
LESXFEZIFXFIQR-LURJTMIESA-N Leu-Gly Chemical compound CC(C)C[C@H](N)C(=O)NCC(O)=O LESXFEZIFXFIQR-LURJTMIESA-N 0.000 claims 28
GPAHWYRSHCKICP-GUBZILKMSA-N Met-Glu-Glu Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O GPAHWYRSHCKICP-GUBZILKMSA-N 0.000 claims 28
SITLTJHOQZFJGG-UHFFFAOYSA-N N-L-alpha-glutamyl-L-valine Natural products CC(C)C(C(O)=O)NC(=O)C(N)CCC(O)=O SITLTJHOQZFJGG-UHFFFAOYSA-N 0.000 claims 28
QWTLUPDHBKBULE-UHFFFAOYSA-N 2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetic acid Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(O)=O QWTLUPDHBKBULE-UHFFFAOYSA-N 0.000 claims 27
XTQFHTHIAKKCTM-YFKPBYRVSA-N Gly-Glu-Gly Chemical compound NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(O)=O XTQFHTHIAKKCTM-YFKPBYRVSA-N 0.000 claims 27
YMDNFPNTIPQMJP-NAKRPEOUSA-N Ser-Ile-Met Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(O)=O YMDNFPNTIPQMJP-NAKRPEOUSA-N 0.000 claims 27
108010069205 aspartyl-phenylalanine Proteins 0.000 claims 27
108010038633 aspartylglutamate Proteins 0.000 claims 27
108010025306 histidylleucine Proteins 0.000 claims 27
108010048818 seryl-histidine Proteins 0.000 claims 27
108010057821 leucylproline Proteins 0.000 claims 26
FLMYSKVSDVHLEW-SVSWQMSJSA-N Ser-Thr-Ile Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O FLMYSKVSDVHLEW-SVSWQMSJSA-N 0.000 claims 25
BTWMICVCQLKKNR-DCAQKATOSA-N Val-Leu-Ser Chemical compound CC(C)[C@H]([NH3+])C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C([O-])=O BTWMICVCQLKKNR-DCAQKATOSA-N 0.000 claims 25
ADSGHMXEAZJJNF-DCAQKATOSA-N Ala-Pro-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N ADSGHMXEAZJJNF-DCAQKATOSA-N 0.000 claims 24
WQWSMEOYXJTFRU-GUBZILKMSA-N Leu-Glu-Ser Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O WQWSMEOYXJTFRU-GUBZILKMSA-N 0.000 claims 24
108010085325 histidylproline Proteins 0.000 claims 24
XABFFGOGKOORCG-CIUDSAMLSA-N Cys-Asp-Leu Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O XABFFGOGKOORCG-CIUDSAMLSA-N 0.000 claims 23
108010006664 gamma-glutamyl-glycyl-glycine Proteins 0.000 claims 23
102000004196 processed proteins & peptides Human genes 0.000 claims 23
108090000765 processed proteins & peptides Proteins 0.000 claims 23
OGNJZUXUTPQVBR-BQBZGAKWSA-N Glu-Gly-Glu Chemical compound OC(=O)CC[C@H](N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(O)=O OGNJZUXUTPQVBR-BQBZGAKWSA-N 0.000 claims 22
YWAQATDNEKZFFK-BYPYZUCNSA-N Gly-Gly-Ser Chemical compound NCC(=O)NCC(=O)N[C@@H](CO)C(O)=O YWAQATDNEKZFFK-BYPYZUCNSA-N 0.000 claims 22
SBVPYBFMIGDIDX-SRVKXCTJSA-N Pro-Pro-Pro Chemical compound OC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)[C@H]2NCCC2)CCC1 SBVPYBFMIGDIDX-SRVKXCTJSA-N 0.000 claims 22
108010016686 methionyl-alanyl-serine Proteins 0.000 claims 22
229920001184 polypeptide Polymers 0.000 claims 22
108010048397 seryl-lysyl-leucine Proteins 0.000 claims 22
VILLWIDTHYPSLC-PEFMBERDSA-N Asp-Glu-Ile Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O VILLWIDTHYPSLC-PEFMBERDSA-N 0.000 claims 21
MBRWOKXNHTUJMB-CIUDSAMLSA-N Cys-Pro-Glu Chemical compound [H]N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O MBRWOKXNHTUJMB-CIUDSAMLSA-N 0.000 claims 21
ILWHFUZZCFYSKT-AVGNSLFASA-N Glu-Lys-Leu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O ILWHFUZZCFYSKT-AVGNSLFASA-N 0.000 claims 21
MSASLZGZQAXVFP-PEDHHIEDSA-N Ile-Met-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O)N MSASLZGZQAXVFP-PEDHHIEDSA-N 0.000 claims 21
YBAFDPFAUTYYRW-UHFFFAOYSA-N N-L-alpha-glutamyl-L-leucine Natural products CC(C)CC(C(O)=O)NC(=O)C(N)CCC(O)=O YBAFDPFAUTYYRW-UHFFFAOYSA-N 0.000 claims 21
108010013835 arginine glutamate Proteins 0.000 claims 21
JLWZLIQRYCTYBD-IHRRRGAJSA-N Leu-Lys-Arg Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O JLWZLIQRYCTYBD-IHRRRGAJSA-N 0.000 claims 20
PWPBLZXWFXJFHE-RHYQMDGZSA-N Leu-Pro-Thr Chemical compound CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(O)=O PWPBLZXWFXJFHE-RHYQMDGZSA-N 0.000 claims 20
108010077112 prolyl-proline Proteins 0.000 claims 20
NMRHDSAOIURTNT-RWMBFGLXSA-N Arg-Leu-Pro Chemical compound CC(C)C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCCN=C(N)N)N NMRHDSAOIURTNT-RWMBFGLXSA-N 0.000 claims 19
HUWYGQOISIJNMK-SIGLWIIPSA-N Ile-Ile-His Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)N HUWYGQOISIJNMK-SIGLWIIPSA-N 0.000 claims 19
FCWFBHMAJZGWRY-XUXIUFHCSA-N Ile-Leu-Met Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)O)N FCWFBHMAJZGWRY-XUXIUFHCSA-N 0.000 claims 19
HBJZFCIVFIBNSV-DCAQKATOSA-N Leu-Arg-Asn Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(O)=O HBJZFCIVFIBNSV-DCAQKATOSA-N 0.000 claims 19
HYIFFZAQXPUEAU-QWRGUYRKSA-N Leu-Gly-Leu Chemical compound CC(C)C[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CC(C)C HYIFFZAQXPUEAU-QWRGUYRKSA-N 0.000 claims 19
BVLPIIBTWIYOML-ZKWXMUAHSA-N Ala-Val-Asp Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O BVLPIIBTWIYOML-ZKWXMUAHSA-N 0.000 claims 18
HOBNTSHITVVNBN-ZPFDUUQYSA-N Asp-Ile-Leu Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC(=O)O)N HOBNTSHITVVNBN-ZPFDUUQYSA-N 0.000 claims 18
SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical compound NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 claims 18
125000002987 valine group Chemical compound [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 18
XWFWAXPOLRTDFZ-FXQIFTODSA-N Ala-Pro-Ser Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O XWFWAXPOLRTDFZ-FXQIFTODSA-N 0.000 claims 17
WATXSTJXNBOHKD-LAEOZQHASA-N Glu-Asp-Val Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O WATXSTJXNBOHKD-LAEOZQHASA-N 0.000 claims 17
MUSGDMDGNGXULI-DCAQKATOSA-N Glu-Glu-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCC(O)=O MUSGDMDGNGXULI-DCAQKATOSA-N 0.000 claims 17
KJBGAZSLZAQDPV-KKUMJFAQSA-N Glu-Phe-Arg Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCC(=O)O)N KJBGAZSLZAQDPV-KKUMJFAQSA-N 0.000 claims 17
DSFYPIUSAMSERP-IHRRRGAJSA-N Leu-Leu-Arg Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N DSFYPIUSAMSERP-IHRRRGAJSA-N 0.000 claims 17
QNBVTHNJGCOVFA-AVGNSLFASA-N Leu-Leu-Glu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CCC(O)=O QNBVTHNJGCOVFA-AVGNSLFASA-N 0.000 claims 17
KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 claims 17
108010086434 alanyl-seryl-glycine Proteins 0.000 claims 17
210000004027 cell Anatomy 0.000 claims 17
108010031719 prolyl-serine Proteins 0.000 claims 17
108010090894 prolylleucine Proteins 0.000 claims 17
108010011667 Ala-Phe-Ala Proteins 0.000 claims 16
QDXQWFBLUVTOFL-FXQIFTODSA-N Asn-Met-Ala Chemical compound C[C@@H](C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)N)N QDXQWFBLUVTOFL-FXQIFTODSA-N 0.000 claims 16
NXTYATMDWQYLGJ-BQBZGAKWSA-N Cys-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CS NXTYATMDWQYLGJ-BQBZGAKWSA-N 0.000 claims 16
DTPOVRRYXPJJAZ-FJXKBIBVSA-N Gly-Arg-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CCCN=C(N)N DTPOVRRYXPJJAZ-FJXKBIBVSA-N 0.000 claims 16
GDOZQTNZPCUARW-YFKPBYRVSA-N Gly-Gly-Glu Chemical compound NCC(=O)NCC(=O)N[C@H](C(O)=O)CCC(O)=O GDOZQTNZPCUARW-YFKPBYRVSA-N 0.000 claims 16
YAALVYQFVJNXIV-KKUMJFAQSA-N His-Leu-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CN=CN1 YAALVYQFVJNXIV-KKUMJFAQSA-N 0.000 claims 16
UNBFGVQVQGXXCK-KKUMJFAQSA-N Phe-Ser-Leu Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O UNBFGVQVQGXXCK-KKUMJFAQSA-N 0.000 claims 16
RWCOTTLHDJWHRS-YUMQZZPRSA-N Pro-Pro Chemical compound OC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCCC1 RWCOTTLHDJWHRS-YUMQZZPRSA-N 0.000 claims 16
KDBHVPXBQADZKY-GUBZILKMSA-N Pro-Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCCC1 KDBHVPXBQADZKY-GUBZILKMSA-N 0.000 claims 16
WBAXJMCUFIXCNI-WDSKDSINSA-N Ser-Pro Chemical compound OC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O WBAXJMCUFIXCNI-WDSKDSINSA-N 0.000 claims 16
239000003795 chemical substances by application Substances 0.000 claims 16
VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 claims 16
108010034529 leucyl-lysine Proteins 0.000 claims 16
KMSGYZQRXPUKGI-BYPYZUCNSA-N Gly-Gly-Asn Chemical compound NCC(=O)NCC(=O)N[C@H](C(O)=O)CC(N)=O KMSGYZQRXPUKGI-BYPYZUCNSA-N 0.000 claims 15
RNMNYMDTESKEAJ-KKUMJFAQSA-N His-Leu-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CN=CN1 RNMNYMDTESKEAJ-KKUMJFAQSA-N 0.000 claims 15
CMNMPCTVCWWYHY-MXAVVETBSA-N Ile-His-Leu Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(C)C)C(=O)O)N CMNMPCTVCWWYHY-MXAVVETBSA-N 0.000 claims 15
VCSBGUACOYUIGD-CIUDSAMLSA-N Leu-Asn-Asp Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O VCSBGUACOYUIGD-CIUDSAMLSA-N 0.000 claims 15
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GVJUTBOZZBTBIG-AVGNSLFASA-N Val-Lys-Arg Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N GVJUTBOZZBTBIG-AVGNSLFASA-N 0.000 claims 1
IJGPOONOTBNTFS-GVXVVHGQSA-N Val-Lys-Glu Chemical compound [H]N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O IJGPOONOTBNTFS-GVXVVHGQSA-N 0.000 claims 1
XPKCFQZDQGVJCX-RHYQMDGZSA-N Val-Lys-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)N)O XPKCFQZDQGVJCX-RHYQMDGZSA-N 0.000 claims 1
DOFAQXCYFQKSHT-SRVKXCTJSA-N Val-Pro-Pro Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 DOFAQXCYFQKSHT-SRVKXCTJSA-N 0.000 claims 1
VIKZGAUAKQZDOF-NRPADANISA-N Val-Ser-Glu Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCC(O)=O VIKZGAUAKQZDOF-NRPADANISA-N 0.000 claims 1
HTONZBWRYUKUKC-RCWTZXSCSA-N Val-Thr-Val Chemical compound CC(C)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(O)=O HTONZBWRYUKUKC-RCWTZXSCSA-N 0.000 claims 1
NLNCNKIVJPEFBC-DLOVCJGASA-N Val-Val-Glu Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CCC(O)=O NLNCNKIVJPEFBC-DLOVCJGASA-N 0.000 claims 1
108010017893 alanyl-alanyl-alanine Proteins 0.000 claims 1
108010024078 alanyl-glycyl-serine Proteins 0.000 claims 1
108010041407 alanylaspartic acid Proteins 0.000 claims 1
108010005233 alanylglutamic acid Proteins 0.000 claims 1
INJRKJPEYSAMPD-UHFFFAOYSA-N aluminum;silicic acid;hydrate Chemical compound O.[Al].[Al].O[Si](O)(O)O INJRKJPEYSAMPD-UHFFFAOYSA-N 0.000 claims 1
150000001412 amines Chemical class 0.000 claims 1
125000000539 amino acid group Chemical group 0.000 claims 1
108010025592 aminoadipoyl-cysteinyl-allylglycine Proteins 0.000 claims 1
235000019270 ammonium chloride Nutrition 0.000 claims 1
108010040443 aspartyl-aspartic acid Proteins 0.000 claims 1
108010093581 aspartyl-proline Proteins 0.000 claims 1
238000013475 authorization Methods 0.000 claims 1
210000003719 b-lymphocyte Anatomy 0.000 claims 1
238000004166 bioassay Methods 0.000 claims 1
230000015572 biosynthetic process Effects 0.000 claims 1
208000035269 cancer or benign tumor Diseases 0.000 claims 1
239000006285 cell suspension Substances 0.000 claims 1
150000001875 compounds Chemical class 0.000 claims 1
238000012258 culturing Methods 0.000 claims 1
230000009089 cytolysis Effects 0.000 claims 1
210000004443 dendritic cell Anatomy 0.000 claims 1
108010009297 diglycyl-histidine Proteins 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
238000005516 engineering process Methods 0.000 claims 1
238000001914 filtration Methods 0.000 claims 1
238000001415 gene therapy Methods 0.000 claims 1
108010064177 glutamine synthetase I Proteins 0.000 claims 1
108010079547 glutamylmethionine Proteins 0.000 claims 1
KZNQNBZMBZJQJO-YFKPBYRVSA-N glyclproline Chemical compound NCC(=O)N1CCC[C@H]1C(O)=O KZNQNBZMBZJQJO-YFKPBYRVSA-N 0.000 claims 1
108010000434 glycyl-alanyl-leucine Proteins 0.000 claims 1
108010033706 glycylserine Proteins 0.000 claims 1
239000003102 growth factor Substances 0.000 claims 1
210000004209 hair Anatomy 0.000 claims 1
208000018706 hematopoietic system disease Diseases 0.000 claims 1
102000056003 human IL15 Human genes 0.000 claims 1
208000015181 infectious disease Diseases 0.000 claims 1
230000010354 integration Effects 0.000 claims 1
108010027338 isoleucylcysteine Proteins 0.000 claims 1
238000002372 labelling Methods 0.000 claims 1
108010047926 leucyl-lysyl-tyrosine Proteins 0.000 claims 1
108010030617 leucyl-phenylalanyl-valine Proteins 0.000 claims 1
MVCNPXUMKZNDRO-OAHLLOKOSA-N lysergene Chemical compound C1=CC(C2=CC(=C)CN([C@@H]2C2)C)=C3C2=CNC3=C1 MVCNPXUMKZNDRO-OAHLLOKOSA-N 0.000 claims 1
108010064235 lysylglycine Proteins 0.000 claims 1
108010017391 lysylvaline Proteins 0.000 claims 1
108010085203 methionylmethionine Proteins 0.000 claims 1
229920000609 methyl cellulose Polymers 0.000 claims 1
239000001923 methylcellulose Substances 0.000 claims 1
238000001823 molecular biology technique Methods 0.000 claims 1
235000016709 nutrition Nutrition 0.000 claims 1
MXHCPCSDRGLRER-UHFFFAOYSA-N pentaglycine Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(O)=O MXHCPCSDRGLRER-UHFFFAOYSA-N 0.000 claims 1
210000005259 peripheral blood Anatomy 0.000 claims 1
239000011886 peripheral blood Substances 0.000 claims 1
210000004976 peripheral blood cell Anatomy 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
108010051242 phenylalanylserine Proteins 0.000 claims 1
108700042769 prolyl-leucyl-glycine Proteins 0.000 claims 1
238000001742 protein purification Methods 0.000 claims 1
210000004989 spleen cell Anatomy 0.000 claims 1
108010071097 threonyl-lysyl-proline Proteins 0.000 claims 1
108010017949 tyrosyl-glycyl-glycine Proteins 0.000 claims 1
108010073969 valyllysine Proteins 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

CZ19991323A 1996-10-25 1997-10-23 Multi-funkční chimérní agonisté hematopoietických receptorů CZ295843B6 (cs)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2962996P	1996-10-25	1996-10-25

Publications (2)

Publication Number	Publication Date
CZ132399A3 CZ132399A3 (cs)	1999-12-15
CZ295843B6 true CZ295843B6 (cs)	2005-11-16

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ID=21850035

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ19991323A CZ295843B6 (cs)	1996-10-25	1997-10-23	Multi-funkční chimérní agonisté hematopoietických receptorů

Country Status (17)

Country	Link
EP (1)	EP0935663A2 (de)
JP (1)	JP2001504689A (de)
KR (1)	KR100497423B1 (de)
AR (1)	AR010041A1 (de)
AU (1)	AU725547B2 (de)
BR (1)	BR9713668A (de)
CA (1)	CA2268742A1 (de)
CZ (1)	CZ295843B6 (de)
IL (1)	IL129565A0 (de)
NO (1)	NO991948L (de)
NZ (1)	NZ335382A (de)
PL (1)	PL333023A1 (de)
RO (1)	RO120919B1 (de)
RU (2)	RU2245887C2 (de)
TW (2)	TW591035B (de)
WO (1)	WO1998017810A2 (de)
ZA (1)	ZA979607B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5581476A (en)	1993-01-28	1996-12-03	Amgen Inc.	Computer-based methods and articles of manufacture for preparing G-CSF analogs
US20020137890A1 (en) *	1997-03-31	2002-09-26	Genentech, Inc.	Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2284127A1 (en) *	1997-04-11	1998-10-22	G.D. Searle & Co.	Flt3 ligand chimeric proteins
BR9905867A (pt) *	1998-11-06	2001-01-23	Bio Sidus S A	Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
WO2002101047A1 (en) *	2001-06-12	2002-12-19	Smithkline Beecham Corporation	Method of identifying compounds that modulate epo primary response gene 1, eprg1, activities
PL371781A1 (en)	2001-07-11	2005-06-27	Maxygen Holdings, Ltd.	G-csf conjugates
DE602004023956D1 (de)	2003-08-18	2009-12-17	Univ California	Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon
EP1888119B1 (de)	2005-06-01	2011-03-09	Maxygen, Inc.	Pegylierte g-csf-polypeptide und herstellungsverfahren dafür
US7550433B2 (en) *	2005-06-03	2009-06-23	Affymax, Inc.	Erythropoietin receptor peptide formulations and uses
EP2535346B1 (de)	2005-08-31	2017-08-02	The Regents of The University of California	Zelluläre Peptidsequenzbibliotheken (CLiPS) und Verwendungsverfahren dafür
WO2007098548A1 (en) *	2006-03-01	2007-09-07	Apollo Life Sciences Limited	A molecule and chimeric molecules thereof
US8293685B2 (en)	2007-07-26	2012-10-23	The Regents Of The University Of California	Methods for enhancing bacterial cell display of proteins and peptides
US10071109B2 (en)	2013-11-06	2018-09-11	Molecular Templates, Inc.	Predictive biomarker for hypoxia-activated prodrug therapy
WO2020198659A1 (en) *	2019-03-28	2020-10-01	Orionis Biosciences, Inc.	Fms-like tyrosine kinase 3 ligand (flt3l)-based chimeric proteins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2069746A1 (en) *	1990-09-28	1992-03-29	Jonathan I. Rosen	Hybrid growth factors
US5376367A (en) *	1991-11-22	1994-12-27	Immunex Corporation	Fusion proteins comprising MGF and IL-3
US5738849A (en) *	1992-11-24	1998-04-14	G. D. Searle & Co.	Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6057133A (en) *	1992-11-24	2000-05-02	G. D. Searle	Multivariant human IL-3 fusion proteins and their recombinant production
US5635599A (en) *	1994-04-08	1997-06-03	The United States Of America As Represented By The Department Of Health And Human Services	Fusion proteins comprising circularly permuted ligands

1997
- 1997-10-23 NZ NZ335382A patent/NZ335382A/xx unknown
- 1997-10-23 CA CA002268742A patent/CA2268742A1/en not_active Abandoned
- 1997-10-23 AU AU51652/98A patent/AU725547B2/en not_active Ceased
- 1997-10-23 CZ CZ19991323A patent/CZ295843B6/cs not_active IP Right Cessation
- 1997-10-23 IL IL12956597A patent/IL129565A0/xx unknown
- 1997-10-23 WO PCT/US1997/020037 patent/WO1998017810A2/en not_active Ceased
- 1997-10-23 BR BR9713668-9A patent/BR9713668A/pt not_active Application Discontinuation
- 1997-10-23 EP EP97946495A patent/EP0935663A2/de not_active Withdrawn
- 1997-10-23 PL PL97333023A patent/PL333023A1/xx unknown
- 1997-10-23 KR KR10-1999-7003635A patent/KR100497423B1/ko not_active Expired - Fee Related
- 1997-10-23 RO RO99-00480A patent/RO120919B1/ro unknown
- 1997-10-23 JP JP51975498A patent/JP2001504689A/ja not_active Abandoned
- 1997-10-23 RU RU99111071/13A patent/RU2245887C2/ru not_active IP Right Cessation
- 1997-10-27 TW TW086116018A patent/TW591035B/zh not_active IP Right Cessation
- 1997-10-27 ZA ZA979607A patent/ZA979607B/xx unknown
- 1997-10-27 TW TW093111460A patent/TW200413407A/zh unknown
- 1997-10-28 AR ARP970104979A patent/AR010041A1/es unknown
1999
- 1999-04-23 NO NO991948A patent/NO991948L/no not_active Application Discontinuation
2005
- 2005-02-24 RU RU2005105360/13A patent/RU2005105360A/ru not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO991948D0 (no)	1999-04-23
TW591035B (en)	2004-06-11
CZ132399A3 (cs)	1999-12-15
WO1998017810A3 (en)	1998-10-15
NZ335382A (en)	2001-03-30
IL129565A0 (en)	2000-02-29
RU2005105360A (ru)	2006-08-10
BR9713668A (pt)	2000-03-08
PL333023A1 (en)	1999-11-08
WO1998017810A2 (en)	1998-04-30
RU2245887C2 (ru)	2005-02-10
AU5165298A (en)	1998-05-15
TW200413407A (en)	2004-08-01
AU725547B2 (en)	2000-10-12
AR010041A1 (es)	2000-05-17
NO991948L (no)	1999-06-23
RO120919B1 (ro)	2006-09-29
JP2001504689A (ja)	2001-04-10
KR20000052812A (ko)	2000-08-25
KR100497423B1 (ko)	2005-07-07
EP0935663A2 (de)	1999-08-18
CA2268742A1 (en)	1998-04-30
ZA979607B (en)	1999-04-28

Legal Events

Date	Code	Title	Description
2000-06-30	PD00	Pending as of 2000-06-30 in czech republic
2006-09-13	MM4A	Patent lapsed due to non-payment of fee	Effective date: 19971023

Publication	Publication Date	Title
CZ295843B6 (cs)	2005-11-16	Multi-funkční chimérní agonisté hematopoietických receptorů
CN113912737A (zh)	2022-01-11	白介素-2/白介素-2受体α融合蛋白和使用方法
US6730303B1 (en)	2004-05-04	Fused G-CSF and IL-3 proteins and uses thereof
AU705083B2 (en)	1999-05-13	Multi-functional hematopoietic receptor agonists
US20040127410A1 (en)	2004-07-01	Circular permuteins of flt3 ligand
AU717733B2 (en)	2000-03-30	Novel G-CSF receptor agonists
US6358505B1 (en)	2002-03-19	G-CSF receptor agonists
WO1997023639A1 (en)	1997-07-03	Process for producing biologically active fused proteins
US6967092B1 (en)	2005-11-22	Multi-functional chimeric hematopoietic receptor agonists
MXPA99003877A (en)	1999-10-14	Multi-functional chimeric hematopoietic receptor agonists
WO1997012978A1 (en)	1997-04-10	NOVEL c-mpl RECEPTOR AGONISTS
CN1242049A (zh)	2000-01-19	多功能嵌合造血受体激动剂
HK1025353A (en)	2000-11-10	Multi-functional chimeric hematopoietic receptor agonists
CZ346799A3 (cs)	2000-03-15	Chimérické proteiny jako flt3 ligandy