TW591035B - Multi-functional chimeric hematopoietic receptor agonists - Google Patents

Multi-functional chimeric hematopoietic receptor agonists Download PDF

Info

Publication number: TW591035B
Authority: TW; Taiwan
Prior art keywords: xaa; identification number; sequence identification; leu; seq
Prior art date: 1996-10-25

Application number

TW086116018A

Other languages

English (en)

Chinese (zh)

Inventor

Wherter Charles A Mc

Yiqing Feng

Kearn John P Mc

Neena L Summers

Nicholas R Staten

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-25

Filing date

1997-10-27

Publication date

2004-06-11

1997-10-27 Application filed by Searle & Co filed Critical Searle & Co

2004-06-11 Application granted granted Critical

2004-06-11 Publication of TW591035B publication Critical patent/TW591035B/zh

Links

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239000012312 sodium hydride Substances 0.000 description 1
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230000002269 spontaneous effect Effects 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000011476 stem cell transplantation Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000013517 stratification Methods 0.000 description 1
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239000000758 substrate Substances 0.000 description 1
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239000000725 suspension Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
229960000278 theophylline Drugs 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
108010061238 threonyl-glycine Proteins 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
229960000187 tissue plasminogen activator Drugs 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
238000010361 transduction Methods 0.000 description 1
230000026683 transduction Effects 0.000 description 1
239000012581 transferrin Substances 0.000 description 1
230000009261 transgenic effect Effects 0.000 description 1
230000005945 translocation Effects 0.000 description 1
102000035160 transmembrane proteins Human genes 0.000 description 1
108091005703 transmembrane proteins Proteins 0.000 description 1
229910052722 tritium Inorganic materials 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
238000013385 tryptic peptide mapping Methods 0.000 description 1
108010015666 tryptophyl-leucyl-glutamic acid Proteins 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
241001430294 unidentified retrovirus Species 0.000 description 1
229960005356 urokinase Drugs 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
239000002821 viper venom Substances 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
210000001835 viscera Anatomy 0.000 description 1
101150099695 vps11 gene Proteins 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
238000001262 western blot Methods 0.000 description 1
210000004885 white matter Anatomy 0.000 description 1
210000005253 yeast cell Anatomy 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Oncology (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

TW086116018A 1996-10-25 1997-10-27 Multi-functional chimeric hematopoietic receptor agonists TW591035B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2962996P	1996-10-25	1996-10-25

Publications (1)

Publication Number	Publication Date
TW591035B true TW591035B (en)	2004-06-11

Family

ID=21850035

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
TW086116018A TW591035B (en)	1996-10-25	1997-10-27	Multi-functional chimeric hematopoietic receptor agonists
TW093111460A TW200413407A (en)	1996-10-25	1997-10-27	Multi-functional chimeric hematopoietic receptor agonist-related pharmaceutical compositions

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
TW093111460A TW200413407A (en)	1996-10-25	1997-10-27	Multi-functional chimeric hematopoietic receptor agonist-related pharmaceutical compositions

Country Status (17)

Country	Link
EP (1)	EP0935663A2 (de)
JP (1)	JP2001504689A (de)
KR (1)	KR100497423B1 (de)
AR (1)	AR010041A1 (de)
AU (1)	AU725547B2 (de)
BR (1)	BR9713668A (de)
CA (1)	CA2268742A1 (de)
CZ (1)	CZ295843B6 (de)
IL (1)	IL129565A0 (de)
NO (1)	NO991948L (de)
NZ (1)	NZ335382A (de)
PL (1)	PL333023A1 (de)
RO (1)	RO120919B1 (de)
RU (2)	RU2245887C2 (de)
TW (2)	TW591035B (de)
WO (1)	WO1998017810A2 (de)
ZA (1)	ZA979607B (de)

Families Citing this family (14)

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US5581476A (en)	1993-01-28	1996-12-03	Amgen Inc.	Computer-based methods and articles of manufacture for preparing G-CSF analogs
US20020137890A1 (en) *	1997-03-31	2002-09-26	Genentech, Inc.	Secreted and transmembrane polypeptides and nucleic acids encoding the same
BR9808514A (pt) *	1997-04-11	2000-05-23	Searle & Co	Proteìnas quiméricas do ligante flt3
BR9905867A (pt) *	1998-11-06	2001-01-23	Bio Sidus S A	Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
WO2002101047A1 (en) *	2001-06-12	2002-12-19	Smithkline Beecham Corporation	Method of identifying compounds that modulate epo primary response gene 1, eprg1, activities
IL159524A0 (en)	2001-07-11	2004-06-01	Maxygen Holdings Ltd	G-csf conjugates
EP1668114B1 (de)	2003-08-18	2009-11-04	The Regents of the University of California	Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon
US7381805B2 (en)	2005-06-01	2008-06-03	Maxygen Holdings, Ltd.	Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF
US7550433B2 (en) *	2005-06-03	2009-06-23	Affymax, Inc.	Erythropoietin receptor peptide formulations and uses
AU2006284651C1 (en)	2005-08-31	2013-09-12	The Regents Of The University Of California	Cellular libraries of peptide sequences (CLiPS) and methods of using the same
WO2007098548A1 (en) *	2006-03-01	2007-09-07	Apollo Life Sciences Limited	A molecule and chimeric molecules thereof
WO2009014726A1 (en)	2007-07-26	2009-01-29	The Regents Of The University Of California	Methods for enhancing bacterial cell display of proteins and peptides
US10071109B2 (en)	2013-11-06	2018-09-11	Molecular Templates, Inc.	Predictive biomarker for hypoxia-activated prodrug therapy
CN113645988A (zh) *	2019-03-28	2021-11-12	奥里尼斯生物科学股份有限公司	基于fms样酪氨酸激酶3配体(flt3l)的嵌合蛋白

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH05502463A (ja) *	1990-09-28	1993-04-28	オーソ・フアーマシユーチカル・コーポレーシヨン	ハイブリツド成長因子
US5376367A (en) *	1991-11-22	1994-12-27	Immunex Corporation	Fusion proteins comprising MGF and IL-3
US5738849A (en) *	1992-11-24	1998-04-14	G. D. Searle & Co.	Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6057133A (en) *	1992-11-24	2000-05-02	G. D. Searle	Multivariant human IL-3 fusion proteins and their recombinant production
US5635599A (en) *	1994-04-08	1997-06-03	The United States Of America As Represented By The Department Of Health And Human Services	Fusion proteins comprising circularly permuted ligands

1997
- 1997-10-23 EP EP97946495A patent/EP0935663A2/de not_active Withdrawn
- 1997-10-23 RU RU99111071/13A patent/RU2245887C2/ru not_active IP Right Cessation
- 1997-10-23 WO PCT/US1997/020037 patent/WO1998017810A2/en not_active Ceased
- 1997-10-23 KR KR10-1999-7003635A patent/KR100497423B1/ko not_active Expired - Fee Related
- 1997-10-23 PL PL97333023A patent/PL333023A1/xx unknown
- 1997-10-23 CA CA002268742A patent/CA2268742A1/en not_active Abandoned
- 1997-10-23 CZ CZ19991323A patent/CZ295843B6/cs not_active IP Right Cessation
- 1997-10-23 RO RO99-00480A patent/RO120919B1/ro unknown
- 1997-10-23 AU AU51652/98A patent/AU725547B2/en not_active Ceased
- 1997-10-23 BR BR9713668-9A patent/BR9713668A/pt not_active Application Discontinuation
- 1997-10-23 NZ NZ335382A patent/NZ335382A/xx unknown
- 1997-10-23 JP JP51975498A patent/JP2001504689A/ja not_active Abandoned
- 1997-10-23 IL IL12956597A patent/IL129565A0/xx unknown
- 1997-10-27 TW TW086116018A patent/TW591035B/zh not_active IP Right Cessation
- 1997-10-27 ZA ZA979607A patent/ZA979607B/xx unknown
- 1997-10-27 TW TW093111460A patent/TW200413407A/zh unknown
- 1997-10-28 AR ARP970104979A patent/AR010041A1/es unknown
1999
- 1999-04-23 NO NO991948A patent/NO991948L/no not_active Application Discontinuation
2005
- 2005-02-24 RU RU2005105360/13A patent/RU2005105360A/ru not_active Application Discontinuation

Also Published As

Publication number	Publication date
CZ295843B6 (cs)	2005-11-16
ZA979607B (en)	1999-04-28
WO1998017810A3 (en)	1998-10-15
PL333023A1 (en)	1999-11-08
RU2005105360A (ru)	2006-08-10
NO991948L (no)	1999-06-23
RO120919B1 (ro)	2006-09-29
EP0935663A2 (de)	1999-08-18
TW200413407A (en)	2004-08-01
NO991948D0 (no)	1999-04-23
WO1998017810A2 (en)	1998-04-30
KR100497423B1 (ko)	2005-07-07
JP2001504689A (ja)	2001-04-10
CZ132399A3 (cs)	1999-12-15
AR010041A1 (es)	2000-05-17
NZ335382A (en)	2001-03-30
CA2268742A1 (en)	1998-04-30
BR9713668A (pt)	2000-03-08
KR20000052812A (ko)	2000-08-25
AU5165298A (en)	1998-05-15
AU725547B2 (en)	2000-10-12
RU2245887C2 (ru)	2005-02-10
IL129565A0 (en)	2000-02-29

Legal Events

Date	Code	Title	Description
2008-05-01	MM4A	Annulment or lapse of patent due to non-payment of fees

Publication	Publication Date	Title
KR102724029B1 (ko)	2024-10-29	포유동물 세포의 특성을 변경하기 위한 인공 마이크로-rna 및 이들 생성물의 조성물을 사용한 포유동물 세포의 변형
TW591035B (en)	2004-06-11	Multi-functional chimeric hematopoietic receptor agonists
TW565570B (en)	2003-12-11	Human IL-13 receptor beta
JPH09511916A (ja)	1997-12-02	核酸伝達系
AU705083B2 (en)	1999-05-13	Multi-functional hematopoietic receptor agonists
US6730303B1 (en)	2004-05-04	Fused G-CSF and IL-3 proteins and uses thereof
US20040127410A1 (en)	2004-07-01	Circular permuteins of flt3 ligand
AU717733B2 (en)	2000-03-30	Novel G-CSF receptor agonists
US6358505B1 (en)	2002-03-19	G-CSF receptor agonists
WO1997023639A1 (en)	1997-07-03	Process for producing biologically active fused proteins
US6967092B1 (en)	2005-11-22	Multi-functional chimeric hematopoietic receptor agonists
AU722759B2 (en)	2000-08-10	Novel C-MPL receptor agonists
MXPA99003877A (en)	1999-10-14	Multi-functional chimeric hematopoietic receptor agonists
CN1242049A (zh)	2000-01-19	多功能嵌合造血受体激动剂
HK1025353A (en)	2000-11-10	Multi-functional chimeric hematopoietic receptor agonists
CN117083384A (zh)	2023-11-17	工程细胞的基因转移载体和方法
CZ346799A3 (cs)	2000-03-15	Chimérické proteiny jako flt3 ligandy