CZ301232B6 - Použití vakcíny na vodné bázi - Google Patents

Použití vakcíny na vodné bázi Download PDF

Info

Publication number: CZ301232B6
Authority: CZ; Czechia
Prior art keywords: hepatitis; vaccine; formaldehyde; month; hav
Prior art date: 1998-05-01

Application number

CZ20004061A

Other languages

Czech (cs)

English (en)

Other versions

CZ20004061A3 (cs

Inventor

Artois@Claude

J. Clark@Michael

Thiriart@Clothilde

Gabriel Jozef Thoelen@Stefan

Original Assignee

Smithkline Beecham Biologicals S. A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-01

Filing date

1999-04-27

Publication date

2009-12-16

1999-04-27 Application filed by Smithkline Beecham Biologicals S. A. filed Critical Smithkline Beecham Biologicals S. A.

2001-04-11 Publication of CZ20004061A3 publication Critical patent/CZ20004061A3/cs

2009-12-16 Publication of CZ301232B6 publication Critical patent/CZ301232B6/cs

Links

229960005486 vaccine Drugs 0.000 title claims abstract description 51
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 5
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract description 96
239000000427 antigen Substances 0.000 claims abstract description 28
102000036639 antigens Human genes 0.000 claims abstract description 28
108091007433 antigens Proteins 0.000 claims abstract description 28
208000002672 hepatitis B Diseases 0.000 claims abstract description 26
241000709721 Hepatovirus A Species 0.000 claims abstract description 17
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims abstract description 15
ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims abstract description 14
208000005252 hepatitis A Diseases 0.000 claims abstract description 14
230000002480 immunoprotective effect Effects 0.000 claims abstract description 4
239000000203 mixture Substances 0.000 claims abstract 4
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 7
241000700721 Hepatitis B virus Species 0.000 claims description 4
101710137302 Surface antigen S Proteins 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 2
229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 1
229940001007 aluminium phosphate Drugs 0.000 abstract 1
229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 description 12
229940024545 aluminum hydroxide Drugs 0.000 description 11
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
229940124914 Havrix Drugs 0.000 description 8
229940124922 Twinrix Drugs 0.000 description 6
239000002671 adjuvant Substances 0.000 description 5
102000004169 proteins and genes Human genes 0.000 description 5
108090000623 proteins and genes Proteins 0.000 description 5
125000003275 alpha amino acid group Chemical group 0.000 description 4
229960000074 biopharmaceutical Drugs 0.000 description 3
238000002255 vaccination Methods 0.000 description 3
229910017119 AlPO Inorganic materials 0.000 description 2
229940124884 Engerix-B Drugs 0.000 description 2
229940096437 Protein S Drugs 0.000 description 2
102000029301 Protein S Human genes 0.000 description 2
108010066124 Protein S Proteins 0.000 description 2
101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 description 2
229940001442 combination vaccine Drugs 0.000 description 2
230000003053 immunization Effects 0.000 description 2
238000002649 immunization Methods 0.000 description 2
108010026228 mRNA guanylyltransferase Proteins 0.000 description 2
239000002245 particle Substances 0.000 description 2
230000000405 serological effect Effects 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
229940024546 aluminum hydroxide gel Drugs 0.000 description 1
SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
230000002238 attenuated effect Effects 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
239000011246 composite particle Substances 0.000 description 1
230000021615 conjugation Effects 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
238000007429 general method Methods 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
229960002348 hepatitis b surface antigen vaccine Drugs 0.000 description 1
230000028993 immune response Effects 0.000 description 1
230000005847 immunogenicity Effects 0.000 description 1
239000002502 liposome Substances 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
238000000034 method Methods 0.000 description 1
229940035032 monophosphoryl lipid a Drugs 0.000 description 1
231100000957 no side effect Toxicity 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
- C12N2770/32434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Communicable Diseases (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Biotechnology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CZ20004061A 1998-05-01 1999-04-27 Použití vakcíny na vodné bázi CZ301232B6 (cs)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9809507.8A GB9809507D0 (en)	1998-05-01	1998-05-01	Novel composition

Publications (2)

Publication Number	Publication Date
CZ20004061A3 CZ20004061A3 (cs)	2001-04-11
CZ301232B6 true CZ301232B6 (cs)	2009-12-16

Family

ID=10831426

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ20004061A CZ301232B6 (cs)	1998-05-01	1999-04-27	Použití vakcíny na vodné bázi

Country Status (28)

Country	Link
EP (1)	EP1073462B1 (de)
JP (2)	JP5138843B2 (de)
KR (1)	KR100612547B1 (de)
CN (1)	CN1263509C (de)
AR (1)	AR016987A1 (de)
AT (1)	ATE345815T1 (de)
AU (1)	AU743759B2 (de)
BR (1)	BR9910157A (de)
CA (1)	CA2331086C (de)
CO (1)	CO5050367A1 (de)
CY (1)	CY1107322T1 (de)
CZ (1)	CZ301232B6 (de)
DE (1)	DE69934108T2 (de)
DK (1)	DK1073462T3 (de)
ES (1)	ES2277437T3 (de)
GB (1)	GB9809507D0 (de)
GC (1)	GC0000101A (de)
HU (1)	HU228209B1 (de)
IL (1)	IL139269A0 (de)
MY (1)	MY128929A (de)
NO (1)	NO20005483L (de)
NZ (1)	NZ507902A (de)
PL (1)	PL190729B1 (de)
PT (1)	PT1073462E (de)
TR (1)	TR200003235T2 (de)
TW (1)	TW553744B (de)
WO (1)	WO1999056772A2 (de)
ZA (1)	ZA200006118B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1513555A (zh) *	2003-07-31	2004-07-21	长春生物制品研究所	甲-乙型肝炎联合疫苗及其冻干制剂
EP1862176A1 (de) *	2006-05-31	2007-12-05	Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH	Ein Verfahren zur Herstellung einer Impfzusammensetzung
EP1862177A1 (de) *	2006-06-01	2007-12-05	Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH	Ein Verfahren zur Herstellung einer Impfzusammensetzung
CN102198270B (zh) *	2011-05-16	2012-06-27	大连汉信生物制药有限公司	一种含铝佐剂乙肝疫苗的制备方法
KR101281098B1 (ko) *	2011-06-30	2013-07-02	주식회사 녹십자	Ｂ형 간염 바이러스 표면 항원상의 에피토프 및 이의 용도
CN102988975A (zh) *	2012-11-30	2013-03-27	深圳康泰生物制品股份有限公司	甲型、乙型肝炎联合疫苗及其制备方法
US9849066B2 (en)	2013-04-24	2017-12-26	Corning Incorporated	Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
WO2020099927A1 (en) *	2018-11-13	2020-05-22	Variation Biotechnologies Inc.	Immunogenic compositions for treatment of hepatitis b

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993024148A1 (en) *	1992-05-23	1993-12-09	Smithkline Beecham Biologicals (S.A.)	Combined vaccines comprising hepatitis b surface antigen and other antigens
WO1996026741A1 (en) *	1995-02-25	1996-09-06	Smithkline Beeecham Biologicals S.A.	Hepatitis b vaccine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0349686A (ja) *	1989-07-11	1991-03-04	Smithkline Biologicals Sa	レトロウイルスｇａｇ蛋白の真核生物細胞における発現
US6372225B1 (en) *	1996-03-23	2002-04-16	The Research Foundation Of Microbial Diseases Of Osaka University	Tetanus toxin functional fragment antigen and tetanus vaccine

1998
- 1998-05-01 GB GBGB9809507.8A patent/GB9809507D0/en not_active Ceased
1999
- 1999-04-27 IL IL13926999A patent/IL139269A0/xx not_active IP Right Cessation
- 1999-04-27 ES ES99924871T patent/ES2277437T3/es not_active Expired - Lifetime
- 1999-04-27 HU HU0101652A patent/HU228209B1/hu unknown
- 1999-04-27 CA CA2331086A patent/CA2331086C/en not_active Expired - Lifetime
- 1999-04-27 PT PT99924871T patent/PT1073462E/pt unknown
- 1999-04-27 TR TR2000/03235T patent/TR200003235T2/xx unknown
- 1999-04-27 EP EP99924871A patent/EP1073462B1/de not_active Expired - Lifetime
- 1999-04-27 AT AT99924871T patent/ATE345815T1/de active
- 1999-04-27 CN CNB998081418A patent/CN1263509C/zh not_active Expired - Lifetime
- 1999-04-27 CZ CZ20004061A patent/CZ301232B6/cs not_active IP Right Cessation
- 1999-04-27 BR BR9910157-2A patent/BR9910157A/pt not_active Application Discontinuation
- 1999-04-27 WO PCT/EP1999/003024 patent/WO1999056772A2/en not_active Ceased
- 1999-04-27 PL PL99344137A patent/PL190729B1/pl unknown
- 1999-04-27 AU AU41379/99A patent/AU743759B2/en not_active Expired
- 1999-04-27 KR KR1020007012162A patent/KR100612547B1/ko not_active Expired - Lifetime
- 1999-04-27 DK DK99924871T patent/DK1073462T3/da active
- 1999-04-27 GC GCP1999139 patent/GC0000101A/xx active
- 1999-04-27 DE DE69934108T patent/DE69934108T2/de not_active Expired - Lifetime
- 1999-04-27 JP JP2000546796A patent/JP5138843B2/ja not_active Expired - Lifetime
- 1999-04-27 NZ NZ507902A patent/NZ507902A/en unknown
- 1999-04-29 AR ARP990102002A patent/AR016987A1/es unknown
- 1999-04-29 MY MYPI99001705A patent/MY128929A/en unknown
- 1999-04-29 CO CO99025940A patent/CO5050367A1/es unknown
- 1999-06-29 TW TW088110991A patent/TW553744B/zh not_active IP Right Cessation
2000
- 2000-10-30 ZA ZA200006118A patent/ZA200006118B/xx unknown
- 2000-10-31 NO NO20005483A patent/NO20005483L/no not_active Application Discontinuation
2007
- 2007-02-08 CY CY20071100163T patent/CY1107322T1/el unknown
2010
- 2010-06-29 JP JP2010148061A patent/JP2010209118A/ja active Pending

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993024148A1 (en) *	1992-05-23	1993-12-09	Smithkline Beecham Biologicals (S.A.)	Combined vaccines comprising hepatitis b surface antigen and other antigens
WO1996026741A1 (en) *	1995-02-25	1996-09-06	Smithkline Beeecham Biologicals S.A.	Hepatitis b vaccine

Also Published As

Publication number	Publication date
PL190729B1 (pl)	2005-12-30
NZ507902A (en)	2002-03-28
CN1308547A (zh)	2001-08-15
HUP0101652A3 (en)	2004-10-28
HU228209B1 (en)	2013-01-28
BR9910157A (pt)	2001-01-09
ATE345815T1 (de)	2006-12-15
NO20005483L (no)	2000-12-08
HUP0101652A1 (hu)	2001-09-28
PL344137A1 (en)	2001-10-08
ES2277437T3 (es)	2007-07-01
GB9809507D0 (en)	1998-07-01
DE69934108T2 (de)	2007-04-19
CO5050367A1 (es)	2001-06-27
JP2010209118A (ja)	2010-09-24
DK1073462T3 (da)	2007-02-26
AR016987A1 (es)	2001-08-01
CA2331086A1 (en)	1999-11-11
TR200003235T2 (tr)	2001-03-21
CN1263509C (zh)	2006-07-12
JP2002513771A (ja)	2002-05-14
NO20005483D0 (no)	2000-10-31
DE69934108D1 (de)	2007-01-04
MY128929A (en)	2007-02-28
WO1999056772A2 (en)	1999-11-11
CA2331086C (en)	2010-06-22
PT1073462E (pt)	2007-01-31
KR20010043224A (ko)	2001-05-25
GC0000101A (en)	2005-06-29
EP1073462A2 (de)	2001-02-07
AU743759B2 (en)	2002-02-07
CZ20004061A3 (cs)	2001-04-11
JP5138843B2 (ja)	2013-02-06
EP1073462B1 (de)	2006-11-22
ZA200006118B (en)	2002-01-30
IL139269A0 (en)	2001-11-25
TW553744B (en)	2003-09-21
WO1999056772A3 (en)	2000-02-03
CY1107322T1 (el)	2012-11-21
KR100612547B1 (ko)	2006-08-11
AU4137999A (en)	1999-11-23
HK1034202A1 (en)	2001-10-19

Legal Events

Date	Code	Title	Description
2019-05-09	MK4A	Patent expired	Effective date: 20190427

Publication	Publication Date	Title
US6013264A (en)	2000-01-11	Vaccine
EP2066344B2 (de)	2016-06-29	Inaktiviertes Poliovirus Mischimpfstoff
JP5232006B2 (ja)	2013-07-10	Ｂ型肝炎ウイルス表面抗原および界面活性剤の両方を含むワクチンの製造
CZ267497A3 (cs)	1998-02-18	Prostředek pro vakcinaci a popužití antigenu hepatitidy B
EP2661277A2 (de)	2013-11-13	Siebenwertiger kombinationsimpfstoff
CZ295954B6 (cs)	2005-12-14	Vakcinační prostředek
JP2010209118A (ja)	2010-09-24	新規組成物
US7144703B2 (en)	2006-12-05	Composition
HK1034202B (en)	2007-06-08	Combined vaccine against hepatitis a and hepatitis b
HK1021142B (en)	2010-05-28	Combined vaccines comprising hepatitis b surface antigen and other antigens
HK1011290B (en)	2000-04-28	Combined vaccines comprising hepatitis b surface antigen and other antigens
HK1137937A (en)	2010-08-13	Combined vaccines comprising hepatitis b surface antigen and other antigens