DD135445A5 - Verfahren zur herstellung eines antibiotischen mittels - Google Patents

Verfahren zur herstellung eines antibiotischen mittels

Info

Publication number
DD135445A5
DD135445A5 DD78204656A DD20465678A DD135445A5 DD 135445 A5 DD135445 A5 DD 135445A5 DD 78204656 A DD78204656 A DD 78204656A DD 20465678 A DD20465678 A DD 20465678A DD 135445 A5 DD135445 A5 DD 135445A5
Authority
DD
German Democratic Republic
Prior art keywords
producing
antibiotic agent
antibiotic
agent
Prior art date
Application number
DD78204656A
Other languages
German (de)
English (en)
Inventor
William W Armstrong
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DD135445A5 publication Critical patent/DD135445A5/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)
DD78204656A 1977-04-27 1978-04-07 Verfahren zur herstellung eines antibiotischen mittels DD135445A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
DD135445A5 true DD135445A5 (de) 1979-05-09

Family

ID=25154289

Family Applications (1)

Application Number Title Priority Date Filing Date
DD78204656A DD135445A5 (de) 1977-04-27 1978-04-07 Verfahren zur herstellung eines antibiotischen mittels

Country Status (38)

Country Link
US (1) US4126680A (fr)
JP (1) JPS53136514A (fr)
AR (1) AR217844A1 (fr)
AT (1) AT360148B (fr)
AU (1) AU503139B1 (fr)
BE (1) BE866419A (fr)
BG (1) BG47943A3 (fr)
CA (1) CA1100875A (fr)
CH (1) CH630260A5 (fr)
CS (1) CS199527B2 (fr)
DD (1) DD135445A5 (fr)
DE (1) DE2817335C3 (fr)
DK (1) DK155977C (fr)
EG (1) EG14348A (fr)
ES (1) ES468749A1 (fr)
FI (3) FI801197A7 (fr)
FR (1) FR2388561A1 (fr)
GB (1) GB1563478A (fr)
GR (1) GR70062B (fr)
HU (1) HU179050B (fr)
IE (1) IE47049B1 (fr)
IL (1) IL54581A0 (fr)
IN (1) IN148197B (fr)
IT (1) IT1094557B (fr)
LU (1) LU79547A1 (fr)
MX (1) MX6087E (fr)
NL (1) NL7804455A (fr)
NO (1) NO148280C (fr)
NZ (1) NZ187046A (fr)
OA (1) OA05949A (fr)
PH (1) PH12962A (fr)
PL (1) PL110459B1 (fr)
PT (1) PT67895B (fr)
RO (2) RO75099A (fr)
SE (1) SE443507B (fr)
YU (1) YU87178A (fr)
ZA (1) ZA782400B (fr)
ZM (1) ZM3878A1 (fr)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (fr) * 1993-04-20 1994-10-26 Nostras S.A. Composition antibiotique contenant de l'oxytétracycline et du glycofurol
CZ301835B6 (cs) 1999-09-14 2010-07-07 Trustees Of Tufts College Zpusob prípravy 7-, 9- nebo 13- substituované tetracyklinové slouceniny, reaktivní tetracyklinový chemický komplex a tetracyklinová sloucenina substituovaná v poloze 7 nebo 9
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6833365B2 (en) 2000-01-24 2004-12-21 Trustees Of Tufts College Tetracycline compounds for treatment of Cryptosporidium parvum related disorders
ATE365710T1 (de) * 2000-03-31 2007-07-15 Tufts College 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen
AU2001259701A1 (en) * 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
WO2001098236A2 (fr) 2000-06-16 2001-12-27 Trustees Of Tufts College Composes de tetracycline 7-phenyl-substituee
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
ATE504562T1 (de) 2000-07-07 2011-04-15 Tufts College 7-, 8- und 9-substitutierte tetracyclinverbindungen
AU2001271616A1 (en) 2000-07-07 2002-01-21 Paratek Pharmaceuticals, Inc 13-substituted methacycline compounds
CZ2003344A3 (cs) 2000-07-07 2003-05-14 Trustees Of Tufts College 9-Substituované minocyklinové sloučeniny
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
BR0112265A (pt) 2000-07-07 2003-06-24 Tufts College Compostos de tetraciclina substituìda, e de sanciclina 7-substituìda, método para tratar um estado responsivo à tetraciclina em um indivìduo, e, composição farmacêutica
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
WO2002072532A1 (fr) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues en position 7,9
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
US6841546B2 (en) 2001-03-14 2005-01-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
EP1381372A2 (fr) 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
EP1399414B1 (fr) 2001-04-24 2010-01-13 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues destines au traitement de la malaria
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2311797A1 (fr) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. Composés de tétracycline 4-dedimethylamino
JP2005526754A (ja) 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド アミノメチル置換されたテトラサイクリン化合物
EP1503981A4 (fr) 2002-03-21 2007-08-15 Paratek Pharm Innc Derives substitues de tetracycline
WO2004006850A2 (fr) 2002-07-12 2004-01-22 Paratek Pharmaceuticals, Inc Composes de tetracycline substituee en 3, 10, et 12a
WO2004038001A2 (fr) 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Composes tetracycline substituee servant au traitement du paludisme
JP4738333B2 (ja) 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド ９−アミノメチルテトラサイクリン化合物のプロドラッグ
WO2005009943A2 (fr) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues
NZ544826A (en) * 2003-07-25 2008-07-31 Warner Chilcott Co Inc A doxycycline metal complex in a solid dosage form
EP2332904A3 (fr) * 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derives des composes de tetracycline
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
WO2006047756A2 (fr) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues
JP2008518025A (ja) * 2004-10-25 2008-05-29 パラテック ファーマシューティカルズ インコーポレイテッド ４−アミノテトラサイクリンおよびその使用の方法
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US20080242642A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
EP1991236A2 (fr) 2006-01-24 2008-11-19 Paratek Pharmaceuticals, Inc. Procede permettant d'accroitre la biodisponibilite orale de tetracyclines
EP2007713A2 (fr) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Isolement de dérivés de la tétracycline
PT2016045E (pt) * 2006-04-24 2015-02-05 Teva Pharma Forma cristalina de tigeciclina e processos para a sua preparação
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
WO2007133797A2 (fr) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Méthodes de régulation de l'expression de gènes ou de produits géniques à l'aide de composés de tétracycline substituée
ES2315123B1 (es) * 2006-09-25 2009-12-30 Divasa-Farmavic, S.A. Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
WO2008045507A2 (fr) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Composés de tétracycline substitués utilisés pour le traitement d'infections à bacillus anthracis
PL2120963T3 (pl) 2006-12-21 2019-05-31 Paratek Pharm Innc Podstawione związki tetracyklinowe do leczenia zaburzeń zapalnych skóry
IL270446B2 (en) * 2006-12-21 2023-10-01 Paratek Pharm Innc A tetracycline compound, a pharmaceutical preparation containing the tetracycline compound, and the tetracycline compound or the pharmaceutical preparation for the treatment of the tetracycline-responsive condition
AU2012230089B2 (en) * 2007-03-23 2013-11-21 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
JP5395052B2 (ja) * 2007-03-23 2014-01-22 モレキュラー リサーチ センター インコーポレイテッド 炎症を処置するための組成物および方法
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
EP2144614A1 (fr) * 2007-04-12 2010-01-20 Paratek Pharmaceuticals, Inc. Procédés pour le traitement de l'amyotrophie spinale à l'aide de composés tétracyclines.
EP2144870A2 (fr) * 2007-04-27 2010-01-20 Paratek Pharmaceuticals, Inc. Procedes de synthese et de purification de composes d'aminoalkyltetracycline
WO2009009042A1 (fr) 2007-07-06 2009-01-15 Paratek Pharmaceuticals, Inc. Procédés servant à synthétiser des composés de tétracycline substituée
MX2010009693A (es) * 2008-03-05 2010-12-20 Paratek Pharm Innc Compuestos de monociclina y metodos de uso de la misma.
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
JP2011517697A (ja) * 2008-04-14 2011-06-16 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
TWI585071B (zh) 2008-05-19 2017-06-01 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
EP2341771A4 (fr) * 2008-09-19 2012-08-15 Paratek Pharm Innc Composés de tétracycline utilisés dans le traitement de la polyarthrite rhumatoïde et méthodes thérapeutiques associées
JP2012523438A (ja) 2009-04-10 2012-10-04 タフツ メディカル センター インコーポレイテッド メタロプロテイナーゼ−１（ｍｍｐ−１）によるｐａｒ−１活性化
LT2707003T (lt) 2011-05-12 2019-10-10 Paratek Pharmaceuticals, Inc. Kristalinės (4s,4as,5ar,12as)-4-dimetilamino-3,10,12,12a-tetrahidroksi-7-[(metoksi(metil)amino)-metil]-1,11-diokso-1,4,4a,5,5a,6,11,12a-oktahidro-naftacen-2-karboksirūgšties amido druskos ir jų panaudojimo būdai
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
EP2805732B1 (fr) * 2013-05-20 2016-09-28 Fundación Comunidad Valenciana Centro de Investigación Principe Felipe Conjugués médicament-polymère pour le traitement de l'amyloïdose
AU2016235237B2 (en) 2015-03-23 2021-03-11 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use
SG11201903846TA (en) 2016-11-01 2019-05-30 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
CA3070663A1 (fr) 2017-07-21 2019-01-24 Almirall, Llc Traitement de lesions non inflammatoires
CN113655052B (zh) * 2021-08-03 2023-12-12 哈尔滨工程大学 基于高活性MgO对四环素类抗生素可视化检测的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) * 1963-01-30 1966-02-02 Chugai Pharmaceutical Co Ltd Hemostatic preparation for injection and process for the production thereof
DK129969B (da) * 1973-01-11 1974-12-09 Rosco Ak Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
PT67895B (en) 1979-11-14
IT1094557B (it) 1985-08-02
ATA300478A (de) 1980-05-15
DK155977C (da) 1989-10-30
NZ187046A (en) 1980-03-05
RO75099A (fr) 1980-12-30
FI801196A7 (fi) 1981-01-01
NO148280C (no) 1983-09-21
DK182578A (da) 1978-10-28
ZA782400B (en) 1979-04-25
HU179050B (en) 1982-08-28
PH12962A (en) 1979-10-19
FR2388561A1 (fr) 1978-11-24
BE866419A (fr) 1978-10-26
OA05949A (fr) 1981-06-30
AT360148B (de) 1980-12-29
DK155977B (da) 1989-06-12
CA1100875A (fr) 1981-05-12
DE2817335C3 (de) 1982-04-22
YU87178A (en) 1984-04-30
MX6087E (es) 1984-11-08
AR217844A1 (es) 1980-04-30
IE780828L (en) 1978-10-27
ZM3878A1 (en) 1978-11-21
FR2388561B1 (fr) 1980-07-18
IN148197B (fr) 1980-11-29
IT7822720A0 (it) 1978-04-26
EG14348A (en) 1984-09-30
US4126680A (en) 1978-11-21
BG47943A3 (bg) 1990-10-15
DE2817335A1 (de) 1978-11-16
JPS5632290B2 (fr) 1981-07-27
DE2817335B2 (de) 1981-06-11
PL110459B1 (en) 1980-07-31
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
CS199527B2 (en) 1980-07-31
RO77953A (fr) 1981-12-25
AU503139B1 (en) 1979-08-23
IL54581A0 (en) 1978-07-31
LU79547A1 (fr) 1979-11-07
IE47049B1 (en) 1983-12-14
JPS53136514A (en) 1978-11-29
PT67895A (en) 1978-05-01
CH630260A5 (fr) 1982-06-15
NO781457L (no) 1978-10-30
FI801197A7 (fi) 1981-01-01
FI781300A7 (fi) 1978-10-28
NO148280B (no) 1983-06-06
GR70062B (fr) 1982-07-26
ES468749A1 (es) 1979-01-01
SE443507B (sv) 1986-03-03
GB1563478A (en) 1980-03-26
NL7804455A (nl) 1978-10-31

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