DD141926A6 - Verfahren zur herstellung von neuen veraetherten hydroxybenzodiheterocyclen - Google Patents

Verfahren zur herstellung von neuen veraetherten hydroxybenzodiheterocyclen Download PDF

Info

Publication number: DD141926A6
Authority: DD; German Democratic Republic
Prior art keywords: formula; alk; group; compound; hydrogen
Prior art date: 1978-02-09

Application number

DD79210909A

Other languages

German (de)

English (en)

Inventor

Knut A Jaeggi

Franz Ostermayer

Herbert Schroeter

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-02-09

Filing date

1979-02-08

Publication date

1980-05-28

1979-02-08 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1980-05-28 Publication of DD141926A6 publication Critical patent/DD141926A6/de

Links

238000000034 method Methods 0.000 title claims description 27
238000002360 preparation method Methods 0.000 title claims description 11
150000001875 compounds Chemical class 0.000 claims description 66
150000003839 salts Chemical class 0.000 claims description 43
239000002253 acid Substances 0.000 claims description 29
239000007858 starting material Substances 0.000 claims description 22
239000001257 hydrogen Substances 0.000 claims description 21
229910052739 hydrogen Inorganic materials 0.000 claims description 21
238000006243 chemical reaction Methods 0.000 claims description 18
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
230000002829 reductive effect Effects 0.000 claims description 10
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
101000588924 Anthopleura elegantissima Delta-actitoxin-Ael1a Proteins 0.000 claims description 5
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 5
XLHUBROMZOAQMV-UHFFFAOYSA-N 1,4-benzosemiquinone Chemical group [O]C1=CC=C(O)C=C1 XLHUBROMZOAQMV-UHFFFAOYSA-N 0.000 claims description 4
229910052760 oxygen Inorganic materials 0.000 claims description 4
125000004432 carbon atom Chemical group C* 0.000 claims description 3
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 3
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125000005336 allyloxy group Chemical group 0.000 description 3
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MYONAGGJKCJOBT-UHFFFAOYSA-N benzimidazol-2-one Chemical compound C1=CC=CC2=NC(=O)N=C21 MYONAGGJKCJOBT-UHFFFAOYSA-N 0.000 description 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
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239000000546 pharmaceutical excipient Substances 0.000 description 1
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229910003446 platinum oxide Inorganic materials 0.000 description 1
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239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
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229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
235000015497 potassium bicarbonate Nutrition 0.000 description 1
239000011736 potassium bicarbonate Substances 0.000 description 1
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
239000000843 powder Substances 0.000 description 1
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230000002035 prolonged effect Effects 0.000 description 1
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
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239000000377 silicon dioxide Substances 0.000 description 1
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239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
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QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
235000011006 sodium potassium tartrate Nutrition 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000003797 solvolysis reaction Methods 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229950000244 sulfanilic acid Drugs 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
210000001177 vas deferen Anatomy 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000025033 vasoconstriction Effects 0.000 description 1
230000024883 vasodilation Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DD79210909A 1978-02-09 1979-02-08 Verfahren zur herstellung von neuen veraetherten hydroxybenzodiheterocyclen DD141926A6 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH145078		1978-02-09
CH559478		1978-05-23

Publications (1)

Publication Number	Publication Date
DD141926A6 true DD141926A6 (de)	1980-05-28

Family

ID=25687688

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD79210909A DD141926A6 (de)	1978-02-09	1979-02-08	Verfahren zur herstellung von neuen veraetherten hydroxybenzodiheterocyclen

Country Status (12)

Country	Link
EP (1)	EP0003758A1 (da)
JP (1)	JPS54117475A (da)
AU (1)	AU4410279A (da)
DD (1)	DD141926A6 (da)
DK (1)	DK52179A (da)
FI (1)	FI790397A7 (da)
GB (1)	GB2014146A (da)
GR (1)	GR72461B (da)
IE (1)	IE790237L (da)
IL (1)	IL56617A0 (da)
NO (1)	NO790409L (da)
PL (1)	PL213252A3 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2905877A1 (de) *	1979-02-16	1980-08-28	Boehringer Mannheim Gmbh	Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
SE8003277L (sv)	1979-05-04	1980-11-05	Continental Pharma	Bensimidazolderivat, deras framstellning och anvendning samt kompositioner innehallande dessa derivat
JPH09502166A (ja) *	1993-07-31	1997-03-04	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	アドレナリン受容体作動薬活性を有する２−ベンゾヘテロシクリルオキシまたはチオプロパノールアミン誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1058822A (en) *	1963-07-30	1967-02-15	Ici Ltd	3-amino-2-hydroxypropoxy heterocyclic derivatives
CH476719A (de) *	1963-07-30	1969-08-15	Ici Ltd	Verfahren zur Herstellung neuer heterocyclischer Derivate
CH624395A5 (da) *	1976-01-08	1981-07-31	Ciba Geigy Ag
GB1595316A (en) *	1977-05-03	1981-08-12	Roche Products Ltd	4-(3-amino-2-hydroxy-propoxy)-benzimidazole derivatives and pharmaceutical compositions containing them
NZ187066A (en) *	1977-05-03	1981-02-11	Hoffmann La Roche	4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones)

1979
- 1979-01-31 EP EP79100273A patent/EP0003758A1/de not_active Withdrawn
- 1979-02-07 GR GR58288A patent/GR72461B/el unknown
- 1979-02-07 IL IL56617A patent/IL56617A0/xx unknown
- 1979-02-07 PL PL21325279A patent/PL213252A3/xx unknown
- 1979-02-07 FI FI790397A patent/FI790397A7/fi unknown
- 1979-02-08 AU AU44102/79A patent/AU4410279A/en not_active Abandoned
- 1979-02-08 GB GB7904509A patent/GB2014146A/en not_active Withdrawn
- 1979-02-08 DK DK52179A patent/DK52179A/da unknown
- 1979-02-08 IE IE790237A patent/IE790237L/xx unknown
- 1979-02-08 NO NO790409A patent/NO790409L/no unknown
- 1979-02-08 DD DD79210909A patent/DD141926A6/de unknown
- 1979-02-09 JP JP1346479A patent/JPS54117475A/ja active Pending

Also Published As

Publication number	Publication date
AU4410279A (en)	1979-08-16
IL56617A0 (en)	1979-05-31
FI790397A7 (fi)	1979-08-10
GR72461B (da)	1983-11-10
GB2014146A (en)	1979-08-22
PL213252A3 (da)	1980-03-24
NO790409L (no)	1979-08-10
IE790237L (en)	1979-08-09
JPS54117475A (en)	1979-09-12
DK52179A (da)	1979-08-10
EP0003758A1 (de)	1979-09-05

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DD141926A6 (de)	1980-05-28	Verfahren zur herstellung von neuen veraetherten hydroxybenzodiheterocyclen
EP0000485A1 (de)	1979-02-07	Piperidino-propanole, ihre Herstellung und pharmazeutische Präparate die diese enthalten
EP0086453B1 (de)	1988-09-28	Thiazaspiranderivate, Verfahren zu ihrer Herstellung und Arzneimittel
DE2458624A1 (de)	1975-07-03	Neue phenoxypropylaminderivate und ein verfahren zu deren herstellung
EP0271099A2 (de)	1988-06-15	Substituierte Aminopropionsäureamide, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung sowie die bei der Herstellung anfallenden neuen Zwischenprodukte
DE1915230B2 (de)	1978-02-23	Hydroxyphenylalkylaminderivate, verfahren zu deren herstellung und arzneimittel auf deren basis
EP0020303B1 (de)	1985-08-28	Guanidine, Verfahren zur Herstellung und pharmazeutische Präparate enthaltend solche Verbindungen
DE2535930B2 (de)	1978-02-09	Abietinsaeureamidderivate und verfahren zu ihrer herstellung
DE2821584A1 (de)	1978-11-30	Neue, pharmazeutisch wirksame verbindungen, verfahren zu ihrer herstellung und arzneimittel
EP0029992B1 (de)	1983-06-29	Neue Aminopropanolderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
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DE2653147A1 (de)	1977-06-08	Tetrahydropyridin- und pyperidinderivate und verfahren zu ihrer herstellung
DD253616A5 (de)	1988-01-27	Verfahren zur herstellung von neuen pleunromutilinderivaten
DE3314196A1 (de)	1983-09-29	Heterocyclylaether
AT355038B (de)	1980-02-11	Verfahren zur herstellung von neuen veraetherten hydroxy-benzimidazolonen, -benzoxazolonen, - -benzoxazinonen, -chinazolinonen und- chino- xazolinonen
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