DD143257A5 - Verfahren zur herstellung von aminoderivaten von 3-alkyl-5-(2-hydroxystyryl)-isoxazolen - Google Patents

Verfahren zur herstellung von aminoderivaten von 3-alkyl-5-(2-hydroxystyryl)-isoxazolen Download PDF

Info

Publication number: DD143257A5
Authority: DD; German Democratic Republic
Prior art keywords: isoxazole; styryl; acid; hydroxy; mol
Prior art date: 1978-04-29

Application number

DD79212522A

Other languages

German (de)

English (en)

Inventor

Peter C Thieme

Fritz-Frieder Fricke

Hans Theobald

Albrecht Franke

Dieter Lenke

Josef Gries

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-29

Filing date

1979-04-26

Publication date

1980-08-13

1979-04-26 Application filed by Basf Ag filed Critical Basf Ag

1980-08-13 Publication of DD143257A5 publication Critical patent/DD143257A5/de

Links

150000001412 amines Chemical class 0.000 title claims description 12
-1 2-HYDROXYSTYRYL Chemical class 0.000 title description 53
CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title description 7
238000004519 manufacturing process Methods 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims description 37
239000002253 acid Substances 0.000 claims description 26
125000004432 carbon atom Chemical group C* 0.000 claims description 22
239000002904 solvent Substances 0.000 claims description 18
238000002360 preparation method Methods 0.000 claims description 14
150000003839 salts Chemical class 0.000 claims description 10
239000011230 binding agent Substances 0.000 claims description 8
238000000034 method Methods 0.000 claims description 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
125000003342 alkenyl group Chemical group 0.000 claims description 2
125000003545 alkoxy group Chemical group 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims description 2
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 33
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 29
238000006243 chemical reaction Methods 0.000 description 29
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 28
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 24
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 20
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 20
239000000243 solution Substances 0.000 description 20
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239000000460 chlorine Substances 0.000 description 16
239000013078 crystal Substances 0.000 description 16
239000000203 mixture Substances 0.000 description 16
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 15
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
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BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DD79212522A 1978-04-29 1979-04-26 Verfahren zur herstellung von aminoderivaten von 3-alkyl-5-(2-hydroxystyryl)-isoxazolen DD143257A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19782818999 DE2818999A1 (de)	1978-04-29	1978-04-29	Aminoderivate von 3-alkyl-5-(2- hydroxystyryl)-isoxazolen

Publications (1)

Publication Number	Publication Date
DD143257A5 true DD143257A5 (de)	1980-08-13

Family

ID=6038372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD79212522A DD143257A5 (de)	1978-04-29	1979-04-26	Verfahren zur herstellung von aminoderivaten von 3-alkyl-5-(2-hydroxystyryl)-isoxazolen

Country Status (19)

Country	Link
US (1)	US4251539A (fr)
EP (1)	EP0005192B1 (fr)
JP (1)	JPS54144365A (fr)
AT (1)	AT366674B (fr)
AU (1)	AU522924B2 (fr)
CA (1)	CA1128051A (fr)
CS (1)	CS207788B2 (fr)
DD (1)	DD143257A5 (fr)
DE (2)	DE2818999A1 (fr)
DK (1)	DK150602C (fr)
ES (1)	ES480046A1 (fr)
FI (1)	FI791363A7 (fr)
GR (1)	GR68708B (fr)
HU (1)	HU178989B (fr)
IE (1)	IE48277B1 (fr)
IL (1)	IL57088A0 (fr)
NO (1)	NO791428L (fr)
YU (1)	YU40994B (fr)
ZA (1)	ZA792025B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2943405A1 (de) *	1979-10-26	1981-05-07	Basf Ag, 6700 Ludwigshafen	Neue aminoderivate des 5-(2-hydroxystyryl)-isoxazols
IE59813B1 (en) *	1986-05-09	1994-04-06	Warner Lambert Co	Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
WO1994022842A1 (fr) *	1993-03-29	1994-10-13	Basf Aktiengesellschaft	Derives de 1-amino-3-phenoxy-propane en tant que modulateurs de la resistance a des agents therapeutiques multiples
AU3486297A (en)	1996-06-17	1998-01-07	Eli Lilly And Company	Drug resistance and multidrug resistance modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH451115A (de) *	1964-09-10	1968-05-15	Ciba Geigy	Verfahren zur Herstellung eines neuen Amins
CA945172A (en) *	1969-02-21	1974-04-09	Imperial Chemical Industries Limited	Alkanolamine derivatives
US3836671A (en) *	1969-02-21	1974-09-17	Ici Ltd	Alkanolamine derivatives for producing beta-adrenergic blockade
BE754405A (fr) *	1969-08-05	1971-02-04	Thomae Gmbh Dr K	Nouveaux beta-aryl-2-aminoalcoxystyrenes
US3624079A (en) *	1969-10-20	1971-11-30	Upjohn Co	5-(phenylstryl)-3methylisoxazoles
DE2624918A1 (de) *	1976-06-03	1977-12-15	Thomae Gmbh Dr K	Arzneimittel mit antiarrhythmischer wirkung

1978
- 1978-04-29 DE DE19782818999 patent/DE2818999A1/de not_active Withdrawn
1979
- 1979-03-16 GR GR58627A patent/GR68708B/el unknown
- 1979-04-11 CA CA325,382A patent/CA1128051A/fr not_active Expired
- 1979-04-11 EP EP79101108A patent/EP0005192B1/fr not_active Expired
- 1979-04-11 DE DE7979101108T patent/DE2961653D1/de not_active Expired
- 1979-04-17 IL IL57088A patent/IL57088A0/xx unknown
- 1979-04-17 US US06/030,927 patent/US4251539A/en not_active Expired - Lifetime
- 1979-04-24 JP JP4991979A patent/JPS54144365A/ja active Granted
- 1979-04-25 CS CS792882A patent/CS207788B2/cs unknown
- 1979-04-26 DD DD79212522A patent/DD143257A5/de unknown
- 1979-04-26 FI FI791363A patent/FI791363A7/fi not_active Application Discontinuation
- 1979-04-27 NO NO791428A patent/NO791428L/no unknown
- 1979-04-27 AU AU46557/79A patent/AU522924B2/en not_active Ceased
- 1979-04-27 YU YU1021/79A patent/YU40994B/xx unknown
- 1979-04-27 HU HU79BA3778A patent/HU178989B/hu not_active IP Right Cessation
- 1979-04-27 AT AT0319779A patent/AT366674B/de not_active IP Right Cessation
- 1979-04-27 ZA ZA792025A patent/ZA792025B/xx unknown
- 1979-04-27 DK DK175179A patent/DK150602C/da not_active IP Right Cessation
- 1979-04-27 ES ES480046A patent/ES480046A1/es not_active Expired
- 1979-08-08 IE IE857/79A patent/IE48277B1/en unknown

Also Published As

Publication number	Publication date
YU102179A (en)	1983-02-28
US4251539A (en)	1981-02-17
HU178989B (en)	1982-07-28
EP0005192B1 (fr)	1981-12-30
EP0005192A1 (fr)	1979-11-14
DK150602C (da)	1987-12-07
ATA319779A (de)	1981-09-15
ES480046A1 (es)	1980-09-01
AU522924B2 (en)	1982-07-01
JPS54144365A (en)	1979-11-10
GR68708B (fr)	1982-02-02
AT366674B (de)	1982-04-26
IL57088A0 (en)	1979-07-25
CA1128051A (fr)	1982-07-20
ZA792025B (en)	1980-06-25
IE790857L (en)	1979-10-29
NO791428L (no)	1979-10-30
FI791363A7 (fi)	1981-01-01
AU4655779A (en)	1979-11-01
CS207788B2 (en)	1981-08-31
YU40994B (en)	1986-10-31
DE2818999A1 (de)	1979-11-15
JPS6320819B2 (fr)	1988-04-30
DE2961653D1 (en)	1982-02-18
IE48277B1 (en)	1984-11-28
DK150602B (da)	1987-04-13
DK175179A (da)	1979-10-30

Publication	Publication Date	Title
EP0117403B1 (fr)	1988-06-01	Dérivés de 6-(Acylaminoaryl)-3(2H)-pyridazinones, leur préparation et utilisation
EP0034276B1 (fr)	1983-11-09	Dérivés phénylpipérazinyle de 1,3,4-oxadiazolylphénols, leur préparation et les compositions thérapeutiques les contenant
EP0687256B1 (fr)	1997-09-03	Derives de l'acide hydroxymethylfurazanne-carboxylique et leur utilisation dans le traitement de maladies cardio-vasculaires
EP0056866B1 (fr)	1985-06-19	Dérivés phénylpipérazines d'hétarylphénoles et d'hétarylanilines, leur préparation et leurs compositions pharmaceutiques
DD143257A5 (de)	1980-08-13	Verfahren zur herstellung von aminoderivaten von 3-alkyl-5-(2-hydroxystyryl)-isoxazolen
EP0011747B1 (fr)	1982-05-19	Dérivés aminopropanols de 6-hydroxy-2,3,4,5-tétrahydro-1H-1-benzazépin-2-ones, procédé pour leur préparation, et compositions pharmaceutiques les contenant
DE3006351A1 (de)	1981-09-17	2- ((3-amino-2- hydroxy-propoxy)-styryl )-verbindungen
EP0027928B1 (fr)	1983-03-09	Dérivés pipéridiniques d'esters de l'acide 4,5-dialkyle-3-hydroxy-pyrrol-2-carboxylique, leur préparation et compositions pharmaceutiques les contenant
EP0027978B1 (fr)	1982-12-29	Dérivés aminés du (hydroxy-2 styryl)-5 isoxazole, procédés pour leur préparation et agents thérapeutiques les contenant
EP0034754A1 (fr)	1981-09-02	2-((3-amino-2-hydroxy-propoxy)-styryl)-isoxazoles, procédé pour leur préparation et préparations pharmaceutiques les contenant
EP0030688B1 (fr)	1983-09-28	Dérivés de pipéridine d'esters de l'acide 3-hydroxy-thiophène-2-carboxylique, leur préparation et préparations pharmaceutiques les contenant
EP0008108B1 (fr)	1982-05-05	Dérivés aminopropanolés de 2-(o-hydroxyphényl)-pyrroles, procédé de préparation et compositions pharmaceutiques les contenant
DE2943406A1 (de)	1981-05-07	Aminoderivate des 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazols
DE2720613A1 (de)	1978-11-16	Aminoderivate von substituierten hydroxy-thiophenen
DE2811638A1 (de)	1979-09-20	Substituierte aryloxy-aminopropanole und verfahren zu deren herstellung
DE2944222A1 (de)	1981-05-14	Neue aminoderivate des 1,2-benzisothiazols
EP0006971B1 (fr)	1981-12-02	Dérivés aminés de 2-méthyl-5-(2-hydroxystyryl)-1,3,4-thiadiazoles, leur procédé de préparation et compositions thérapeutiques les contenant
EP0025528B1 (fr)	1982-12-29	1-(2-Acétylphénylthio)-3-alkylamino-2-propanols et leurs sels d'addition acides, procédé pour leur préparation et médicaments les contenant
DE2760038C2 (fr)	1989-02-16
EP0005186A1 (fr)	1979-11-14	2-Alcoyl-5-(2-hydroxy-styryl)-isoxazoles et leur procédé de préparation
DE2711382A1 (de)	1978-09-21	Aminoderivate des 3-methyl-4-hydroxy- 1,2-benzisoxazols, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel