DD148584A5 - Verfahren zur thermischen stabilisierung und verbesserung der formbestaendigkeit von weichgelatine-kapseln - Google Patents

Verfahren zur thermischen stabilisierung und verbesserung der formbestaendigkeit von weichgelatine-kapseln Download PDF

Info

Publication number: DD148584A5
Authority: DD; German Democratic Republic
Prior art keywords: film; capsules; soft gelatin; gelatin capsules; film coating
Prior art date: 1979-02-01

Application number

DD80218609A

Other languages

German (de)

English (en)

Inventor

Peter Schmidt

Josef Prochazka

Irmgard Boehrer

Original Assignee

Heumann Ludwig & Co Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-02-01

Filing date

1980-01-23

Publication date

1981-06-03

1980-01-23 Application filed by Heumann Ludwig & Co Gmbh filed Critical Heumann Ludwig & Co Gmbh

1981-06-03 Publication of DD148584A5 publication Critical patent/DD148584A5/de

Links

238000000034 method Methods 0.000 title claims abstract description 19
230000006641 stabilisation Effects 0.000 title claims abstract description 5
238000011105 stabilization Methods 0.000 title claims abstract description 5
239000002775 capsule Substances 0.000 title abstract description 27
239000007903 gelatin capsule Substances 0.000 claims abstract description 42
239000007888 film coating Substances 0.000 claims abstract description 23
238000009501 film coating Methods 0.000 claims abstract description 23
229920000642 polymer Polymers 0.000 claims abstract description 9
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 9
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 9
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 9
238000000576 coating method Methods 0.000 claims description 7
239000013543 active substance Substances 0.000 claims description 6
239000011248 coating agent Substances 0.000 claims description 6
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
229920002678 cellulose Polymers 0.000 claims description 3
229920003086 cellulose ether Polymers 0.000 claims description 3
125000005397 methacrylic acid ester group Chemical group 0.000 claims description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
239000004480 active ingredient Substances 0.000 abstract description 7
239000002904 solvent Substances 0.000 abstract description 5
238000003860 storage Methods 0.000 abstract description 3
230000002035 prolonged effect Effects 0.000 abstract description 2
239000000243 solution Substances 0.000 description 28
239000007921 spray Substances 0.000 description 22
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 21
229920000159 gelatin Polymers 0.000 description 19
235000019322 gelatine Nutrition 0.000 description 19
108010010803 Gelatin Proteins 0.000 description 17
239000008273 gelatin Substances 0.000 description 17
235000011852 gelatine desserts Nutrition 0.000 description 17
229920001223 polyethylene glycol Polymers 0.000 description 17
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
239000002202 Polyethylene glycol Substances 0.000 description 16
238000005507 spraying Methods 0.000 description 15
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
238000002360 preparation method Methods 0.000 description 13
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 10
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 10
229960004063 propylene glycol Drugs 0.000 description 10
235000013772 propylene glycol Nutrition 0.000 description 10
239000004922 lacquer Substances 0.000 description 9
239000003973 paint Substances 0.000 description 8
239000011877 solvent mixture Substances 0.000 description 8
238000003756 stirring Methods 0.000 description 8
229920003091 Methocel™ Polymers 0.000 description 6
239000000203 mixture Substances 0.000 description 6
235000011187 glycerol Nutrition 0.000 description 5
239000004014 plasticizer Substances 0.000 description 5
229920002494 Zein Polymers 0.000 description 4
230000000052 comparative effect Effects 0.000 description 4
238000004090 dissolution Methods 0.000 description 4
239000003814 drug Substances 0.000 description 4
239000000975 dye Substances 0.000 description 4
238000011049 filling Methods 0.000 description 4
-1 for example Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
239000005019 zein Substances 0.000 description 4
229940093612 zein Drugs 0.000 description 4
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
229920001577 copolymer Polymers 0.000 description 3
239000000463 material Substances 0.000 description 3
229920000609 methyl cellulose Polymers 0.000 description 3
239000001923 methylcellulose Substances 0.000 description 3
235000010981 methylcellulose Nutrition 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
239000007787 solid Substances 0.000 description 3
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
206010011224 Cough Diseases 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
239000001856 Ethyl cellulose Substances 0.000 description 2
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
229920003148 Eudragit® E polymer Polymers 0.000 description 2
239000001828 Gelatine Substances 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
239000008186 active pharmaceutical agent Substances 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 2
239000013065 commercial product Substances 0.000 description 2
DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
229940079593 drug Drugs 0.000 description 2
229920001249 ethyl cellulose Polymers 0.000 description 2
235000019325 ethyl cellulose Nutrition 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
229940041616 menthol Drugs 0.000 description 2
238000000465 moulding Methods 0.000 description 2
239000003921 oil Substances 0.000 description 2
229920002545 silicone oil Polymers 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
TYCHBDHDMFEQMC-UHFFFAOYSA-N 3-(dimethylamino)-2-methylprop-2-enoic acid Chemical compound CN(C)C=C(C)C(O)=O TYCHBDHDMFEQMC-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
229920003083 Kollidon® VA64 Polymers 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
229920003072 Plasdone™ povidone Polymers 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000954 anitussive effect Effects 0.000 description 1
229940124584 antitussives Drugs 0.000 description 1
235000013871 bee wax Nutrition 0.000 description 1
239000012166 beeswax Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
206010006451 bronchitis Diseases 0.000 description 1
229940097217 cardiac glycoside Drugs 0.000 description 1
239000002368 cardiac glycoside Substances 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000001055 chewing effect Effects 0.000 description 1
229960003333 chlorhexidine gluconate Drugs 0.000 description 1
YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
FHHZOYXKOICLGH-UHFFFAOYSA-N dichloromethane;ethanol Chemical compound CCO.ClCCl FHHZOYXKOICLGH-UHFFFAOYSA-N 0.000 description 1
ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000003292 glue Substances 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
206010022000 influenza Diseases 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000155 melt Substances 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
229920003145 methacrylic acid copolymer Polymers 0.000 description 1
229940117841 methacrylic acid copolymer Drugs 0.000 description 1
YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
201000009240 nasopharyngitis Diseases 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000003605 opacifier Substances 0.000 description 1
RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
230000002028 premature Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
229940085605 saccharin sodium Drugs 0.000 description 1
238000013112 stability test Methods 0.000 description 1
229930002534 steroid glycoside Natural products 0.000 description 1
150000008143 steroidal glycosides Chemical class 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
239000002966 varnish Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells

Landscapes

Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)

DD80218609A 1979-02-01 1980-01-23 Verfahren zur thermischen stabilisierung und verbesserung der formbestaendigkeit von weichgelatine-kapseln DD148584A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2903778A DE2903778C2 (de)	1979-02-01	1979-02-01	Verwendung von Hydroxypropylmethylcellulose zum Überziehen von den pharmazeutischen Wirkstoff in der Hülle enthaltenden Weichgelatine-Buccalkapseln

Publications (1)

Publication Number	Publication Date
DD148584A5 true DD148584A5 (de)	1981-06-03

Family

ID=6061893

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD80218609A DD148584A5 (de)	1979-02-01	1980-01-23	Verfahren zur thermischen stabilisierung und verbesserung der formbestaendigkeit von weichgelatine-kapseln

Country Status (20)

Country	Link
JP (1)	JPS55104212A (cs)
AR (1)	AR223202A1 (cs)
AT (1)	AT372607B (cs)
AU (1)	AU5488780A (cs)
BE (1)	BE881462A (cs)
CA (1)	CA1142084A (cs)
CS (1)	CS222299B2 (cs)
DD (1)	DD148584A5 (cs)
DE (1)	DE2903778C2 (cs)
DK (1)	DK42880A (cs)
FR (1)	FR2447720A1 (cs)
GB (1)	GB2043442A (cs)
GR (1)	GR70084B (cs)
HU (1)	HU183053B (cs)
IL (1)	IL59137A (cs)
IT (1)	IT8067057A0 (cs)
NL (1)	NL8000634A (cs)
PT (1)	PT70706A (cs)
SE (1)	SE8000467L (cs)
ZA (1)	ZA80382B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5953410A (ja) *	1982-09-20	1984-03-28	Fujisawa Pharmaceut Co Ltd	新型ソフトカプセル剤
CH666405A5 (de) *	1985-06-24	1988-07-29	Ciba Geigy Ag	Feste, haltbare darreichungsformen mit elastischem filmueberzug.
US5068110A (en) *	1987-09-29	1991-11-26	Warner-Lambert Company	Stabilization of enteric coated dosage form
JPH02205A (ja) *	1987-11-09	1990-01-05	Taisho Pharmaceut Co Ltd	香料含有ソフトカプセル用コーティング剤
FR2698560B1 (fr) *	1992-11-30	1995-02-03	Virbac Laboratoires	Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications.
US6030641A (en) *	1997-06-03	2000-02-29	Uni Colloid Kabushiki Kaisha	Sustained release capsule and method for preparing the same
US20070053972A1 (en) *	2005-09-08	2007-03-08	Cadbury Adams Usa Llc.	Gelatin capsules containing actives
AR126384A1 (es) *	2021-07-06	2023-10-11	Scherer Technologies Llc R P	Cápsula blanda

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE695234C (de) *	1937-10-30	1940-08-20	Schering Ag	Verfahren zum Schutz von in fester, kristalliner Fersplittern
CH476499A (de) *	1964-12-31	1969-08-15	Ciba Geigy	Mischung zum Überziehen von Rektal-Kapseln
DE1617671C3 (de) *	1967-03-07	1980-07-03	A. Nattermann & Cie Gmbh, 5000 Koeln	Weichgelatine-Kapseln mit erhöhter Wärmestabilität
DE1767425B2 (de) *	1968-05-09	1973-05-17	R P Scherer GmbH, 6930 Eberbach	Verfahren zur herstellung von magensaftresistenten gelatinekapseln
BE757715A (fr) *	1969-10-21	1971-04-20	Ciba Geigy	Revetement pour capsules en gelatine et procede pour leur preparation

1979
- 1979-02-01 DE DE2903778A patent/DE2903778C2/de not_active Expired
1980
- 1980-01-15 AT AT0019280A patent/AT372607B/de not_active IP Right Cessation
- 1980-01-16 IT IT8067057A patent/IT8067057A0/it unknown
- 1980-01-16 IL IL59137A patent/IL59137A/xx unknown
- 1980-01-17 PT PT70706A patent/PT70706A/pt unknown
- 1980-01-21 SE SE8000467A patent/SE8000467L/ not_active Application Discontinuation
- 1980-01-21 GR GR60993A patent/GR70084B/el unknown
- 1980-01-23 AU AU54887/80A patent/AU5488780A/en not_active Abandoned
- 1980-01-23 ZA ZA00800382A patent/ZA80382B/xx unknown
- 1980-01-23 DD DD80218609A patent/DD148584A5/de unknown
- 1980-01-24 AR AR279725A patent/AR223202A1/es active
- 1980-01-25 JP JP769480A patent/JPS55104212A/ja active Pending
- 1980-01-25 GB GB8002576A patent/GB2043442A/en not_active Withdrawn
- 1980-01-28 CS CS80585A patent/CS222299B2/cs unknown
- 1980-01-28 FR FR8001763A patent/FR2447720A1/fr not_active Withdrawn
- 1980-01-28 HU HU80177A patent/HU183053B/hu unknown
- 1980-01-31 BE BE0/199196A patent/BE881462A/fr not_active IP Right Cessation
- 1980-01-31 CA CA000344841A patent/CA1142084A/en not_active Expired
- 1980-01-31 DK DK42880A patent/DK42880A/da not_active Application Discontinuation
- 1980-01-31 NL NL8000634A patent/NL8000634A/nl not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPS55104212A (en)	1980-08-09
FR2447720A1 (fr)	1980-08-29
DE2903778A1 (de)	1980-08-07
AU5488780A (en)	1980-08-07
GR70084B (cs)	1982-07-30
GB2043442A (en)	1980-10-08
CS222299B2 (en)	1983-06-24
BE881462A (fr)	1980-05-16
DK42880A (da)	1980-08-02
SE8000467L (sv)	1980-08-02
HU183053B (en)	1984-04-28
AR223202A1 (es)	1981-07-31
CA1142084A (en)	1983-03-01
IT8067057A0 (it)	1980-01-16
PT70706A (de)	1980-02-01
ATA19280A (de)	1983-03-15
AT372607B (de)	1983-10-25
NL8000634A (nl)	1980-08-05
DE2903778C2 (de)	1982-06-03
IL59137A (en)	1983-10-31
ZA80382B (en)	1981-01-28

Publication	Publication Date	Title
DE2336218C3 (de)	1985-11-14	Orale Arzneiform
DE69518820T2 (de)	2001-02-22	Rotogranulat und Beschichtung von Acetaminophen, Pseudoephedrin, Chlorpheniramin und, gegebenenfalls, Dextromethorphan
DE69429119T2 (de)	2002-07-18	Verfahren zur herstellung von gefriergetrockneten arzneistoffdosierungsformen
DE69703897T2 (de)	2001-06-21	Filmbildende polymerzusammensetzungen für kapseln
DE69203242T2 (de)	1996-03-14	Arzneimittel bestehend aus diltiazem in retardformen.
DE69020758T2 (de)	1995-12-07	Die Wirkstoffabgabe steuerndes Überzugsmaterial für lang wirksame Formulierungen.
DE60128215T2 (de)	2008-01-10	Beschichtungszusammensetzung zur geschmacksmaskierung
AT396329B (de)	1993-08-25	Pharmazeutische granulate und verfahren zu ihrer herstellung
AT396330B (de)	1993-08-25	Verfahren zur herstellung einer festen haltbaren darreichungsform
DE3915575C2 (de)	1997-07-03	Ranitidinhydrochlorid-Tablette
DE69813602T2 (de)	2003-11-06	Venlafaxinhaltiges arzneimittel mit verlängerter wirkstoffabgabe
LU81503A1 (de)	1980-08-08	Arzneimittel-retardform mit unloeslichen poroesen diffusioshuellen
DE3148802A1 (de)	1982-08-05	Tabletten mit einem gehalt an erythromycin-base
DE69429964T2 (de)	2002-10-02	Feste, therapeutische oder hygienische, mucoadhäsive Zusammensetzung zur Verabreichung durch Auftragen auf der Mund-schleimhaut oder der Nasen-schleimhaut
EP4076392B1 (de)	2025-02-26	Lösliche rückschicht für otf
EP0378137A2 (de)	1990-07-18	Neue Arzneiform
DD148584A5 (de)	1981-06-03	Verfahren zur thermischen stabilisierung und verbesserung der formbestaendigkeit von weichgelatine-kapseln
DE2301664A1 (de)	1974-08-01	Nitroglycerin und polyvinylpyrrolidon in homogener phase enthaltende mischungen
DE2854651A1 (de)	1979-07-12	Ueberzugsmittel fuer feste medikamente
EP2632443B1 (de)	2014-09-17	Herstellung orodispersibler filme
EP0175671A1 (de)	1986-03-26	Pharmazeutische Zubereitung sowie Verfahren zum Darreichen dieser pharmazeutischen Zubereitung
DE3233764C2 (de)	1987-05-07	Verfahren zur Herstellung oraler Dosierungseinheiten
DE2616748A1 (de)	1976-10-28	Darmloesliche kapseln
DE3877621T2 (de)	1993-05-13	Trockene orale theophyllinzubereitung mit verzoegerter freisetzung.
DE2105110A1 (de)	1971-08-12	Neuartiges Medikament