DD159908A5 - Fuellmaterial fuer schnellfluessigkeitschromatographie und verfahren fuer dessen herstellung - Google Patents

Fuellmaterial fuer schnellfluessigkeitschromatographie und verfahren fuer dessen herstellung Download PDF

Info

Publication number: DD159908A5
Authority: DD; German Democratic Republic
Prior art keywords: gel; units; item; vinyl; carboxylic acid
Prior art date: 1980-06-25

Application number

DD81231105A

Other languages

German (de)

English (en)

Inventor

Yuzo Yanagihara

Kohji Noguchi

Makoto Honda

Original Assignee

Asahi Chemical Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-25

Filing date

1981-06-24

Publication date

1983-04-13

1980-06-25 Priority claimed from JP8524380A external-priority patent/JPS5730945A/ja

1980-12-26 Priority claimed from JP55183703A external-priority patent/JPS57108662A/ja

1981-06-24 Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind

1983-04-13 Publication of DD159908A5 publication Critical patent/DD159908A5/de

Links

238000000034 method Methods 0.000 title claims abstract description 23
239000000463 material Substances 0.000 title claims abstract description 22
238000004587 chromatography analysis Methods 0.000 title claims 2
239000012530 fluid Substances 0.000 title claims 2
238000004519 manufacturing process Methods 0.000 title description 4
239000000446 fuel Substances 0.000 title 1
238000004132 cross linking Methods 0.000 claims abstract description 41
239000000178 monomer Substances 0.000 claims abstract description 41
150000001732 carboxylic acid derivatives Chemical class 0.000 claims abstract description 32
229920001577 copolymer Polymers 0.000 claims abstract description 32
229920001567 vinyl ester resin Polymers 0.000 claims abstract description 32
239000000945 filler Substances 0.000 claims abstract description 17
IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims abstract description 15
ZFSLODLOARCGLH-UHFFFAOYSA-N isocyanuric acid Chemical group OC1=NC(O)=NC(O)=N1 ZFSLODLOARCGLH-UHFFFAOYSA-N 0.000 claims abstract description 15
238000011049 filling Methods 0.000 claims abstract description 12
238000010557 suspension polymerization reaction Methods 0.000 claims abstract description 11
238000004811 liquid chromatography Methods 0.000 claims abstract description 8
238000002360 preparation method Methods 0.000 claims abstract description 7
230000008569 process Effects 0.000 claims abstract description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 45
150000002148 esters Chemical group 0.000 claims description 38
239000002245 particle Substances 0.000 claims description 34
239000000203 mixture Substances 0.000 claims description 31
238000007127 saponification reaction Methods 0.000 claims description 29
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 21
229920002307 Dextran Polymers 0.000 claims description 19
KOMNUTZXSVSERR-UHFFFAOYSA-N 1,3,5-tris(prop-2-enyl)-1,3,5-triazinane-2,4,6-trione Chemical compound C=CCN1C(=O)N(CC=C)C(=O)N(CC=C)C1=O KOMNUTZXSVSERR-UHFFFAOYSA-N 0.000 claims description 16
229920001223 polyethylene glycol Polymers 0.000 claims description 12
238000011084 recovery Methods 0.000 claims description 11
UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical group CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 claims description 6
-1 polyethylene Polymers 0.000 claims description 4
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 4
125000004432 carbon atom Chemical group C* 0.000 claims description 3
MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 claims description 3
229920002554 vinyl polymer Polymers 0.000 claims description 3
239000002202 Polyethylene glycol Substances 0.000 claims description 2
YCUBDDIKWLELPD-UHFFFAOYSA-N ethenyl 2,2-dimethylpropanoate Chemical compound CC(C)(C)C(=O)OC=C YCUBDDIKWLELPD-UHFFFAOYSA-N 0.000 claims description 2
BLZSRIYYOIZLJL-UHFFFAOYSA-N ethenyl pentanoate Chemical compound CCCCC(=O)OC=C BLZSRIYYOIZLJL-UHFFFAOYSA-N 0.000 claims description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
BGUAPYRHJPWVEM-UHFFFAOYSA-N 2,2-dimethyl-4-pentenoic acid Chemical compound OC(=O)C(C)(C)CC=C BGUAPYRHJPWVEM-UHFFFAOYSA-N 0.000 claims 1
229920001634 Copolyester Polymers 0.000 claims 1
239000004698 Polyethylene Substances 0.000 claims 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
229920000573 polyethylene Polymers 0.000 claims 1
238000005227 gel permeation chromatography Methods 0.000 abstract description 29
239000000499 gel Substances 0.000 description 215
238000004458 analytical method Methods 0.000 description 39
239000011148 porous material Substances 0.000 description 25
239000000126 substance Substances 0.000 description 25
102000004169 proteins and genes Human genes 0.000 description 23
108090000623 proteins and genes Proteins 0.000 description 23
239000007788 liquid Substances 0.000 description 22
OZAIFHULBGXAKX-UHFFFAOYSA-N 2,2'-azo-bis-isobutyronitrile Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 20
238000006243 chemical reaction Methods 0.000 description 19
DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 16
229920000642 polymer Polymers 0.000 description 16
238000000926 separation method Methods 0.000 description 16
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
125000002887 hydroxy group Chemical group [H]O* 0.000 description 13
239000002904 solvent Substances 0.000 description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
239000012736 aqueous medium Substances 0.000 description 12
238000010828 elution Methods 0.000 description 12
125000004185 ester group Chemical group 0.000 description 11
238000006116 polymerization reaction Methods 0.000 description 10
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 9
239000007864 aqueous solution Substances 0.000 description 9
239000003085 diluting agent Substances 0.000 description 9
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
108010062374 Myoglobin Proteins 0.000 description 7
102000036675 Myoglobin Human genes 0.000 description 7
108010088751 Albumins Proteins 0.000 description 6
102000009027 Albumins Human genes 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
108010058846 Ovalbumin Proteins 0.000 description 6
229940092253 ovalbumin Drugs 0.000 description 6
238000000862 absorption spectrum Methods 0.000 description 5
238000011088 calibration curve Methods 0.000 description 5
238000001914 filtration Methods 0.000 description 5
229920002451 polyvinyl alcohol Polymers 0.000 description 5
235000019422 polyvinyl alcohol Nutrition 0.000 description 5
210000002966 serum Anatomy 0.000 description 5
239000003381 stabilizer Substances 0.000 description 5
BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 4
239000004372 Polyvinyl alcohol Substances 0.000 description 4
NNBZCPXTIHJBJL-UHFFFAOYSA-N decalin Chemical compound C1CCCC2CCCCC21 NNBZCPXTIHJBJL-UHFFFAOYSA-N 0.000 description 4
238000005259 measurement Methods 0.000 description 4
239000011118 polyvinyl acetate Substances 0.000 description 4
229920002689 polyvinyl acetate Polymers 0.000 description 4
239000000243 solution Substances 0.000 description 4
239000000725 suspension Substances 0.000 description 4
210000002700 urine Anatomy 0.000 description 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
102000002572 Alpha-Globulins Human genes 0.000 description 3
108010068307 Alpha-Globulins Proteins 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
108091003079 Bovine Serum Albumin Proteins 0.000 description 3
239000004793 Polystyrene Substances 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000004480 active ingredient Substances 0.000 description 3
229940098773 bovine serum albumin Drugs 0.000 description 3
150000001720 carbohydrates Chemical class 0.000 description 3
230000000052 comparative effect Effects 0.000 description 3
238000009826 distribution Methods 0.000 description 3
239000003999 initiator Substances 0.000 description 3
239000007870 radical polymerization initiator Substances 0.000 description 3
239000000523 sample Substances 0.000 description 3
229920003170 water-soluble synthetic polymer Polymers 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
239000004342 Benzoyl peroxide Substances 0.000 description 2
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 2
102000006395 Globulins Human genes 0.000 description 2
108010044091 Globulins Proteins 0.000 description 2
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
230000008901 benefit Effects 0.000 description 2
235000019400 benzoyl peroxide Nutrition 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
238000010586 diagram Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
AOGQPLXWSUTHQB-UHFFFAOYSA-N hexyl acetate Chemical compound CCCCCCOC(C)=O AOGQPLXWSUTHQB-UHFFFAOYSA-N 0.000 description 2
210000003734 kidney Anatomy 0.000 description 2
208000017169 kidney disease Diseases 0.000 description 2
208000019423 liver disease Diseases 0.000 description 2
239000002609 medium Substances 0.000 description 2
239000012488 sample solution Substances 0.000 description 2
238000004062 sedimentation Methods 0.000 description 2
239000001488 sodium phosphate Substances 0.000 description 2
229910000162 sodium phosphate Inorganic materials 0.000 description 2
235000011008 sodium phosphates Nutrition 0.000 description 2
238000001179 sorption measurement Methods 0.000 description 2
241000894007 species Species 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
230000008961 swelling Effects 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
229940116269 uric acid Drugs 0.000 description 2
PXXNTAGJWPJAGM-UHFFFAOYSA-N vertaline Natural products C1C2C=3C=C(OC)C(OC)=CC=3OC(C=C3)=CC=C3CCC(=O)OC1CC1N2CCCC1 PXXNTAGJWPJAGM-UHFFFAOYSA-N 0.000 description 2
JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 1
MWZJGRDWJVHRDV-UHFFFAOYSA-N 1,4-bis(ethenoxy)butane Chemical compound C=COCCCCOC=C MWZJGRDWJVHRDV-UHFFFAOYSA-N 0.000 description 1
OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 description 1
COXCGWKSEPPDAA-UHFFFAOYSA-N 2,4-dimethylpentanenitrile Chemical compound CC(C)CC(C)C#N COXCGWKSEPPDAA-UHFFFAOYSA-N 0.000 description 1
WDQMWEYDKDCEHT-UHFFFAOYSA-N 2-ethylhexyl 2-methylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C(C)=C WDQMWEYDKDCEHT-UHFFFAOYSA-N 0.000 description 1
FRIBMENBGGCKPD-UHFFFAOYSA-N 3-(2,3-dimethoxyphenyl)prop-2-enal Chemical compound COC1=CC=CC(C=CC=O)=C1OC FRIBMENBGGCKPD-UHFFFAOYSA-N 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
238000004438 BET method Methods 0.000 description 1
102100031102 C-C motif chemokine 4 Human genes 0.000 description 1
101100054773 Caenorhabditis elegans act-2 gene Proteins 0.000 description 1
201000009030 Carcinoma Diseases 0.000 description 1
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
YIVJZNGAASQVEM-UHFFFAOYSA-N Lauroyl peroxide Chemical compound CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC YIVJZNGAASQVEM-UHFFFAOYSA-N 0.000 description 1
101000878457 Macrocallista nimbosa FMRFamide Proteins 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
230000009471 action Effects 0.000 description 1
239000003463 adsorbent Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
239000003513 alkali Substances 0.000 description 1
150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
239000012888 bovine serum Substances 0.000 description 1
230000008859 change Effects 0.000 description 1
239000007810 chemical reaction solvent Substances 0.000 description 1
229910052804 chromium Inorganic materials 0.000 description 1
239000011651 chromium Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
229940109239 creatinine Drugs 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
238000010612 desalination reaction Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
LSXWFXONGKSEMY-UHFFFAOYSA-N di-tert-butyl peroxide Chemical compound CC(C)(C)OOC(C)(C)C LSXWFXONGKSEMY-UHFFFAOYSA-N 0.000 description 1
229910001873 dinitrogen Inorganic materials 0.000 description 1
DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000012847 fine chemical Substances 0.000 description 1
239000007789 gas Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
238000002329 infrared spectrum Methods 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
GJRQTCIYDGXPES-UHFFFAOYSA-N iso-butyl acetate Natural products CC(C)COC(C)=O GJRQTCIYDGXPES-UHFFFAOYSA-N 0.000 description 1
FGKJLKRYENPLQH-UHFFFAOYSA-M isocaproate Chemical compound CC(C)CCC([O-])=O FGKJLKRYENPLQH-UHFFFAOYSA-M 0.000 description 1
OQAGVSWESNCJJT-UHFFFAOYSA-N isovaleric acid methyl ester Natural products COC(=O)CC(C)C OQAGVSWESNCJJT-UHFFFAOYSA-N 0.000 description 1
150000002576 ketones Chemical group 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000003990 molecular pathway Effects 0.000 description 1
QYZFTMMPKCOTAN-UHFFFAOYSA-N n-[2-(2-hydroxyethylamino)ethyl]-2-[[1-[2-(2-hydroxyethylamino)ethylamino]-2-methyl-1-oxopropan-2-yl]diazenyl]-2-methylpropanamide Chemical compound OCCNCCNC(=O)C(C)(C)N=NC(C)(C)C(=O)NCCNCCO QYZFTMMPKCOTAN-UHFFFAOYSA-N 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
239000006179 pH buffering agent Substances 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000009877 rendering Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
239000011800 void material Substances 0.000 description 1
239000011240 wet gel Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
- B01J20/285—Porous sorbents based on polymers
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28047—Gels
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28057—Surface area, e.g. B.E.T specific surface area
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/12—Hydrolysis

Landscapes

Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Dispersion Chemistry (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)

DD81231105A 1980-06-25 1981-06-24 Fuellmaterial fuer schnellfluessigkeitschromatographie und verfahren fuer dessen herstellung DD159908A5 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP8524380A JPS5730945A (en)	1980-06-25	1980-06-25	Hydrophilic filler for gel permeation chromatography
JP55183703A JPS57108662A (en)	1980-12-26	1980-12-26	Filler for high speed liquid chromatography

Publications (1)

Publication Number	Publication Date
DD159908A5 true DD159908A5 (de)	1983-04-13

Family

ID=26426260

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD81231105A DD159908A5 (de)	1980-06-25	1981-06-24	Fuellmaterial fuer schnellfluessigkeitschromatographie und verfahren fuer dessen herstellung

Country Status (6)

Country	Link
US (1)	US4368275A (fr)
EP (1)	EP0043074B1 (fr)
CA (1)	CA1157996A (fr)
DD (1)	DD159908A5 (fr)
DE (1)	DE3166309D1 (fr)
SU (1)	SU1311631A3 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57168157A (en) *	1981-02-12	1982-10-16	Asahi Chem Ind Co Ltd	High performance liquid chromatography column and analysis method using the same
JPS57190003A (en) *	1981-05-18	1982-11-22	Asahi Chem Ind Co Ltd	Wholly porous activated gel
JPS5861463A (ja) *	1981-10-07	1983-04-12	Kureha Chem Ind Co Ltd	液体クロマトグラフイ−用担体及び該担体を用いる脂溶性物質の分離精製方法
CA1204720A (fr) *	1982-09-30	1986-05-20	Hajimu Kitahara	Produits de garnissage pour colonnes chromatographiques; methode d'analyse d'un melange enantiomere a l'aide de ces produits
US4543363A (en) *	1983-06-15	1985-09-24	Asahi Kasei Kogyo Kabushiki Kaisha	Ion exchanger having hydroxyl groups bonded directly to backbone skeleton
US4904519A (en) *	1986-05-12	1990-02-27	Minnesota Mining And Manufacturing Company	Ink-receptive sheet
DE3778113D1 (de) *	1986-10-24	1992-05-14	Asahi Chemical Ind	Vernetztes hydrophobes polymer und verfahren zu seiner herstellung.
LT3061B (en)	1992-07-16	1994-10-25	Fermentas Biotech Inst	Process for the preparation of polymeric gels for sorbents manufacturing
US6573327B1 (en)	1997-04-01	2003-06-03	Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha	Highly stable aqueous solution of partially saponified vinyl ester resin
US6881761B2 (en)	2000-05-29	2005-04-19	Showa Denko K.K.	Porous polymer particle, anion exchanger, producing method thereof, column for ion chromatography, and method for measuring anions
EP1160260B1 (fr) *	2000-05-29	2011-04-13	Showa Denko K.K.	Particules polymériques poreuses, échangeurs d'anions, leur procédé de fabrication, colonne de chromatographie ionique, et procédé de mesure d'anions
JP4717253B2 (ja) *	2000-12-19	2011-07-06	昭和電工株式会社	多孔質重合体粒子、耐アルカリ性陰イオン交換体、その製造方法、イオンクロマトグラフィー用カラム、及び陰イオン測定方法
JP4268347B2 (ja) *	2001-05-30	2009-05-27	富士フイルム株式会社	乾式分析素子用の管理血清
EP1275436A1 (fr) *	2001-07-09	2003-01-15	Showa Denko Kabushiki Kaisha	Matériau de garnissage et cartouche pour l'extraction en phase solide
US20080154007A1 (en) *	2004-12-28	2008-06-26	Kaneka Corporation	Cross-Linked Polymer Particle and Manufacturing Method Thereof
US20090039018A1 (en) *	2007-08-08	2009-02-12	Jordi Howard C	Suspension homopolymerization of an isocyanurates
GB201405624D0 (en) *	2014-03-28	2014-05-14	Synthomer Uk Ltd	Method of making a branched polymer, a branched polymer and uses of such a polymer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL6702806A (fr) *	1966-03-31	1967-10-02
JPS5265597A (en) *	1975-11-27	1977-05-31	Sumitomo Chem Co Ltd	Preparation of high polimeric materials with improved water absorption
JPS52138077A (en) *	1976-03-09	1977-11-17	Toyo Soda Mfg Co Ltd	Production of porous polyvinyl alcohol hard gel
US4314032A (en)	1978-10-26	1982-02-02	Kureha Kagaku Kogyo Kabushiki Kaisha	Crosslinked polyvinyl alcohol gel

1981
- 1981-06-10 US US06/272,230 patent/US4368275A/en not_active Expired - Lifetime
- 1981-06-11 CA CA000379558A patent/CA1157996A/fr not_active Expired
- 1981-06-23 EP EP81104826A patent/EP0043074B1/fr not_active Expired
- 1981-06-23 DE DE8181104826T patent/DE3166309D1/de not_active Expired
- 1981-06-24 DD DD81231105A patent/DD159908A5/de unknown
- 1981-06-24 SU SU813303096A patent/SU1311631A3/ru active

Also Published As

Publication number	Publication date
EP0043074A3 (en)	1982-01-13
SU1311631A3 (ru)	1987-05-15
CA1157996A (fr)	1983-11-29
EP0043074A2 (fr)	1982-01-06
EP0043074B1 (fr)	1984-09-26
US4368275A (en)	1983-01-11
DE3166309D1 (en)	1984-10-31

Publication	Publication Date	Title
DD159908A5 (de)	1983-04-13	Fuellmaterial fuer schnellfluessigkeitschromatographie und verfahren fuer dessen herstellung
DE69316231T2 (de)	1998-08-20	Selektive, die porengrösse betreffende chemische modifikation poröser materialien
DE3851616T2 (de)	1995-02-09	Makroporöse Polymermembranen, ihre Herstellung und Verwendung zur Abtrennung von Polymere.
EP0175990B1 (fr)	1991-06-19	Membrane pour porter des réactifs, méthode pour sa préparation et son utilisation comme moyen analytique et dans des méthodes analytiques
EP1910433B1 (fr)	2014-11-05	Polymère hydrophile réticulé
DE60038123T2 (de)	2009-03-05	Weitporige partikel für chromatographie hergestellt durch suspensionspolymerisation
DE60104364T2 (de)	2005-08-04	Organisch/Anorganisches Hybrid-Hydrogel und Verfahren zu seiner Herstellung
DE2524754C2 (de)	1982-12-09	Verfahren zur Herstellung poröser Mischpolymerisate
DE69303602T2 (de)	1997-03-06	Herstellung von oberflächenfunktionalisierten polymer-teilchen
DE69927792T2 (de)	2006-07-20	Chromatographische vorrichtung
EP0154246B1 (fr)	1988-07-13	Supports de phase pour la chromatographie de partage de macromolécules, procédé pour leur préparation et leur application
DE3888564T2 (de)	1994-10-20	Verfahren zur Herstellung von vernetzten Polymerteilchen.
DE2503774A1 (de)	1975-08-07	Verfahren zur herstellung von ionenaustauschern aus hydrophilen polymeren gelen
DE3040106C2 (de)	1983-07-14	Hydrophiles Füllmaterial für die Chromatographie
DE60026017T2 (de)	2006-08-10	Sulfoniertes polymerharz und dessen herstellung
DE3783706T2 (de)	1993-07-01	Feinteilchen-cellulose und verfahren zu deren herstellung.
DE69731444T2 (de)	2005-10-13	Alkyliertes poröses harz, verfahren zu seiner herstellung und seine verwendung
DE69020246T2 (de)	1996-01-18	Chromatographie auf einem kontinuierlichem polymer.
DE102017000631A1 (de)	2018-07-26	Chromatographiemedium mit gebundenen Mikroglobuli und Verfahren zu dessen Herstellung
DE3609021A1 (de)	1986-09-25	Chromatographisches trennmedium fuer die schnelle analyse von kleinen proben
DE68908147T2 (de)	1993-12-16	Feine teilchen von poröser ionenaustauschercellulose, herstellungsverfahren und affinitätsträger.
DD202626A5 (de)	1983-09-28	Eine fluessigkeitschromatographie-saeule, verfahren zu ihrer herstellung und ihrem einsatz bei der fraktionierung
DE1918399A1 (de)	1970-12-23	Verfahren zur Herstellung eines poroesen,vernetzten Mischpolymers,insbesondere zur Verwendung als Ionenaustauscherharz
DE69410763T2 (de)	1998-11-12	Microsphäre und Verfahren zu deren Herstellung
DE3300366C2 (fr)	1989-04-27