DD227048A5 - Verfahren zur herstellung eines roentgenkontrastmittels - Google Patents

Verfahren zur herstellung eines roentgenkontrastmittels Download PDF

Info

Publication number: DD227048A5
Authority: DD; German Democratic Republic
Prior art keywords: barium sulfate; crystals; suspension; lignosulfonic acid; coarser
Prior art date: 1983-08-26

Application number

DD84266333A

Other languages

German (de)

English (en)

Inventor

Heide M Boessler

Klaus Lehmann

Original Assignee

Roehm Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-26

Filing date

1984-08-16

Publication date

1985-09-11

1984-08-16 Application filed by Roehm Gmbh filed Critical Roehm Gmbh

1985-09-11 Publication of DD227048A5 publication Critical patent/DD227048A5/de

Links

238000000034 method Methods 0.000 title claims abstract 8
238000004519 manufacturing process Methods 0.000 title claims description 3
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims abstract description 78
239000002872 contrast media Substances 0.000 claims abstract description 15
239000002245 particle Substances 0.000 claims abstract description 13
238000009826 distribution Methods 0.000 claims abstract description 6
230000002902 bimodal effect Effects 0.000 claims abstract description 5
229940039231 contrast media Drugs 0.000 claims abstract 2
239000000725 suspension Substances 0.000 claims description 16
FOGYNLXERPKEGN-UHFFFAOYSA-N 3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfopropyl)phenoxy]propane-1-sulfonic acid Chemical compound COC1=CC=CC(CC(CS(O)(=O)=O)OC=2C(=CC(CCCS(O)(=O)=O)=CC=2)OC)=C1O FOGYNLXERPKEGN-UHFFFAOYSA-N 0.000 claims description 11
239000000203 mixture Substances 0.000 claims description 10
239000013078 crystal Substances 0.000 claims description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 6
239000003513 alkali Substances 0.000 claims description 6
229920001732 Lignosulfonate Polymers 0.000 claims description 4
239000000654 additive Substances 0.000 claims description 4
239000000843 powder Substances 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
238000002156 mixing Methods 0.000 claims description 3
239000007864 aqueous solution Substances 0.000 claims description 2
239000004615 ingredient Substances 0.000 claims description 2
239000007791 liquid phase Substances 0.000 claims 1
238000005507 spraying Methods 0.000 claims 1
239000007900 aqueous suspension Substances 0.000 abstract description 3
239000002253 acid Substances 0.000 abstract description 2
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal citrate Chemical class 0.000 abstract 1
239000001509 sodium citrate Substances 0.000 description 10
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 10
229920005552 sodium lignosulfonate Polymers 0.000 description 7
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
239000000600 sorbitol Substances 0.000 description 5
235000010356 sorbitol Nutrition 0.000 description 5
230000002378 acidificating effect Effects 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
210000002784 stomach Anatomy 0.000 description 3
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 2
230000000996 additive effect Effects 0.000 description 2
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 2
239000013530 defoamer Substances 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
229960001462 sodium cyclamate Drugs 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
235000012216 bentonite Nutrition 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
229920005610 lignin Polymers 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000000047 product Substances 0.000 description 1
239000012264 purified product Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000003871 sulfonates Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0404—X-ray contrast preparations containing barium sulfate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Inorganic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Analysing Materials By The Use Of Radiation (AREA)
Apparatus For Radiation Diagnosis (AREA)

DD84266333A 1983-08-26 1984-08-16 Verfahren zur herstellung eines roentgenkontrastmittels DD227048A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3330769A DE3330769A1 (de)	1983-08-26	1983-08-26	Roentgenkontrastmittel

Publications (1)

Publication Number	Publication Date
DD227048A5 true DD227048A5 (de)	1985-09-11

Family

ID=6207472

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD84266333A DD227048A5 (de)	1983-08-26	1984-08-16	Verfahren zur herstellung eines roentgenkontrastmittels

Country Status (8)

Country	Link
EP (1)	EP0135765B1 (fr)
JP (1)	JPS6061537A (fr)
AT (1)	ATE58296T1 (fr)
CA (1)	CA1230549A (fr)
DD (1)	DD227048A5 (fr)
DE (2)	DE3330769A1 (fr)
ES (1)	ES8506453A1 (fr)
ZA (1)	ZA846625B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62153229A (ja) *	1985-12-27	1987-07-08	Nippon Oil Co Ltd	皮膚マ−カ−
JP3717007B2 (ja) *	1995-12-08	2005-11-16	和三平井	新規なバリウム粉末製剤、それを用いた上部消化管造影用極超高濃度バリウム懸濁液、およびこれらの製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3689630A (en) *	1968-09-09	1972-09-05	Sakai Chemical Industry Co	Barium sulfate contrast media
NL7500169A (en) *	1975-01-07	1976-07-09	Josephus Henricus Joannes Ruij	Combined radiography of gall bladder and gastro-intestinal tract - using an oil-contg. X-ray contrast agent

1983
- 1983-08-26 DE DE3330769A patent/DE3330769A1/de not_active Withdrawn
1984
- 1984-07-03 ES ES533964A patent/ES8506453A1/es not_active Expired
- 1984-08-10 EP EP84109534A patent/EP0135765B1/fr not_active Expired - Lifetime
- 1984-08-10 DE DE8484109534T patent/DE3483597D1/de not_active Expired - Lifetime
- 1984-08-10 AT AT84109534T patent/ATE58296T1/de active
- 1984-08-16 DD DD84266333A patent/DD227048A5/de not_active IP Right Cessation
- 1984-08-21 JP JP59172548A patent/JPS6061537A/ja active Pending
- 1984-08-24 CA CA000461708A patent/CA1230549A/fr not_active Expired
- 1984-08-24 ZA ZA846625A patent/ZA846625B/xx unknown

Also Published As

Publication number	Publication date
CA1230549A (fr)	1987-12-22
ES533964A0 (es)	1985-08-16
ZA846625B (en)	1985-04-24
DE3483597D1 (de)	1990-12-20
EP0135765B1 (fr)	1990-11-14
ES8506453A1 (es)	1985-08-16
EP0135765A2 (fr)	1985-04-03
JPS6061537A (ja)	1985-04-09
ATE58296T1 (de)	1990-11-15
EP0135765A3 (en)	1988-08-17
DE3330769A1 (de)	1985-03-21

Legal Events

Date	Code	Title	Description
2000-01-20	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
EP0133444B1 (fr)	1988-09-07	Procédé de préparation de sulfate de barium d'une fluidité et densité augmentée convenant comme composant assombrissant dans des agents de contraste pour rayons X, produit obtenu par ce procédé et agent de contraste pour rayons X obtenu à partir de ce produit
DE69026555T2 (de)	1996-09-19	Feste zubereitung von aktivem vitamin d3 mit verbesserter stabilität
DE2609039B2 (de)	1980-02-14	Verfahren zum Herstellen von beständigem Natriumpercarbonat
CH630069A5 (de)	1982-05-28	Verfahren zur herstellung von neuen cystein-derivaten.
DE102004031181A1 (de)	2006-01-19	Phosphatadsorbens
DE2945790A1 (de)	1980-05-29	Neutrales kristallines salz einer basischen l-aminosaeure mit l-apfelsaeure und verfahren zu dessen herstellung
DE2630586A1 (de)	1977-08-11	Waessrige emulsion von perfluorkohlenstoffverbindungen mit 9 bis 11 kohlenstoffatomen, verfahren zu ihrer herstellung und ihre verwendung als blutersatzmittel und perfusionsfluessigkeit
DE1192369B (de)	1965-05-06	Roentgenkontrastmittel
DE1443755C3 (de)	1978-12-07	Arzneimittel mit Antiplasminwirkung
DD227048A5 (de)	1985-09-11	Verfahren zur herstellung eines roentgenkontrastmittels
DE3429436C2 (fr)	1992-04-16
DE1768655A1 (de)	1971-11-18	Neue Salze der N-Carbamylglutaminsaeure und der N-Carbamylasparaginsaeure
DD202017A5 (de)	1983-08-24	Verfahren zur herstellung von calciumoxaprozin
CH432726A (de)	1967-03-31	Röntgenkontrastmittel und Verfahren zu dessen Herstellung
DE3233894C2 (de)	1994-05-11	Stabile Natriumaluminosilikatsuspensionen
CH403798A (de)	1965-12-15	Verfahren zur Herstellung eines Amprotropin enthaltenden Arzneimittels
DD241071A5 (de)	1986-11-26	Verfahren zur herstellung eines salzes von dobutamin
DE2028025C (de)	1972-12-28	Röntgenkontrastmittel
AT205170B (de)	1959-09-10	Verfahren zur Herstellung von in Wasser schwerlöslichen Salzen der Tetracycline
EP0139997B1 (fr)	1987-07-29	Gel de phosphate d'aluminium basique, sa préparation et son emploi
DE3443270A1 (de)	1986-05-28	Menadioncholinbisulfit-addukt und verfahren zu dessen herstellung
AT204694B (de)	1959-08-10	Verfahren zur Herstellung von kristallinen Komplexverbindungen des Tetracyclins
DE102022103160A1 (de)	2023-08-10	Pulver/Granulat zur Herstellung eines Duschgels oder Shampoos
DE902110C (de)	1954-01-18	Verfahren zur Herstellung eines loeslichen pulverisierten Pektinpraeparates
DE2028025B (de)	1972-04-13	Röntgenkontrastmittel