DD229151A5 - Verfahren zur herstellung von gewebeplasminogenaktivatoren - Google Patents

Verfahren zur herstellung von gewebeplasminogenaktivatoren Download PDF

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Publication number: DD229151A5
Authority: DD; German Democratic Republic
Prior art keywords: gpa; yeast; dna; pho5; promoter
Prior art date: 1983-11-21

Application number

DD84269628A

Other languages

German (de)

English (en)

Inventor

Bernd Meyhack

Albert Hinnen

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-21

Filing date

1984-11-19

Publication date

1985-10-30

1983-11-21 Priority claimed from GB838331045A external-priority patent/GB8331045D0/en

1984-11-19 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1985-10-30 Publication of DD229151A5 publication Critical patent/DD229151A5/de

Links

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- C12N9/6424—Serine endopeptidases (3.4.21)
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- C12N15/90—Stable introduction of foreign DNA into chromosome
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)

DD84269628A 1983-11-21 1984-11-19 Verfahren zur herstellung von gewebeplasminogenaktivatoren DD229151A5 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB838331045A GB8331045D0 (en)	1983-11-21	1983-11-21	Synthesis of fibrinolytic agents by yeast
GB848423112A GB8423112D0 (en)	1983-11-21	1984-09-13	Synthesis of fibrino lytic agents by yeast

Publications (1)

Publication Number	Publication Date
DD229151A5 true DD229151A5 (de)	1985-10-30

Family

ID=26287024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD84269628A DD229151A5 (de)	1983-11-21	1984-11-19	Verfahren zur herstellung von gewebeplasminogenaktivatoren

Country Status (17)

Country	Link
EP (1)	EP0143081B1 (da)
JP (1)	JPS6119489A (da)
KR (1)	KR930002889B1 (da)
AU (1)	AU595478B2 (da)
DD (1)	DD229151A5 (da)
DE (1)	DE3479520D1 (da)
DK (1)	DK164941C (da)
ES (1)	ES8609471A1 (da)
FI (1)	FI86746C (da)
GR (1)	GR80966B (da)
HU (1)	HU201115B (da)
IE (1)	IE57699B1 (da)
IL (1)	IL73568A (da)
NO (1)	NO844618L (da)
NZ (1)	NZ210266A (da)
PH (1)	PH22337A (da)
PT (1)	PT79518B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR78180B (da) *	1982-04-15	1984-09-26	Genentech Inc
US7138505B1 (en)	1984-01-12	2006-11-21	Novartis Vaccines And Diagnostics, Inc.	Factor VIII:C nucleic acid molecules
JPS61502655A (ja) *	1984-07-09	1986-11-20	インテグレ−テッド・ジェネティックス・インコ−ポレ−テッド	酵母クロ−ニングビヒクル
NZ213647A (en) *	1984-10-01	1989-05-29	Integrated Genetics Inc	Recombinant human tissue plasminogen activator (tpa) modified in n-linked glycosylation pattern
JPS624233A (ja) *	1985-07-01	1987-01-10	Toyobo Co Ltd	組織性プラスミノ−ゲン活性化因子の製造法
JPS6229975A (ja) *	1985-08-01	1987-02-07	Mitsui Toatsu Chem Inc	粗ｔＰＡの精製法
GB8521496D0 (en) *	1985-08-29	1985-10-02	Ciba Geigy Ag	Repressible yeast promoters
EP0216573B1 (en) *	1985-09-18	1990-11-22	Green Cross Corporation	Yeast promoter and method of producing heterologous proteins
USH2055H1 (en) *	1985-09-20	2002-12-03	Zymogenetics, Inc.	Expression of tissue-type plasminogen activator in bacteria
GB8530631D0 (en)	1985-12-12	1986-01-22	Ciba Geigy Ag	Thrombin inhibitors
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.
US5106741A (en) *	1985-12-20	1992-04-21	The Upjohn Company	Tissue plasminogen activator (TPA) analogs
US4898825A (en) *	1986-05-07	1990-02-06	Mitsui Toatsu Chemicals, Incorporated	Methods for purification of single-chain and double-chain tissue plasminogen activator
ZA872534B (en) *	1986-05-08	1987-11-25	Phillips Petroleum Co	Yeast production of streptokinase
PT84991B (pt) *	1986-06-06	1990-03-08	Genentech Inc	Processo para a producao de actividador do plasminogenio biologicamente activo
JPS6463378A (en) *	1986-08-11	1989-03-09	Mitsui Toatsu Chemicals	Separation of single stranded tpa and double standard tpa
GB8621118D0 (en) *	1986-09-01	1986-10-08	Whitbread & Co Plc	Stabilised polypeptides
DE3789413T2 (de)	1986-10-03	1994-07-28	Ciba Geigy Ag	Lymphokin-ähnliche Peptide.
PT86162B (pt) *	1986-11-21	1990-11-20	Smithkline Beecham Corp	Expressao de proteina recombinante
ZA879286B (en)	1986-12-16	1988-10-26	Smith Kline Rit	New plasminogen activators
US5149533A (en) *	1987-06-04	1992-09-22	Zymogenetics, Inc.	Modified t-PA with kringle-/replaced by another kringle
US5089409A (en) *	1989-09-28	1992-02-18	Monsanto Company	Method of increasing specific activity of t-pa
US5326700A (en) *	1990-11-06	1994-07-05	Eli Lilly And Company	DNA sequences encoding t-PA derivatives with cleavable sites
WO1995004823A1 (en) *	1993-08-04	1995-02-16	Ciba-Geigy Ag	High molecular weight desulphatohirudin
PT801682E (pt)	1995-02-09	2002-03-28	Behringwerke Ag	Processo para a producao de proteinas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4775622A (en) *	1982-03-08	1988-10-04	Genentech, Inc.	Expression, processing and secretion of heterologous protein by yeast
AR241654A1 (es) *	1982-05-05	1992-10-30	Genentech Inc	Procedimiento para producir activador de plasminogeno de tejido humano.
GB2125047B (en) *	1982-08-09	1986-02-19	Ciba Geigy Ag	Yeast hybrid vectors and their use for the production of polypeptides
EP0174835A1 (en) *	1984-09-11	1986-03-19	The Upjohn Company	Human tissue plasminogen activator and recombinant DNA compounds
NZ213647A (en) *	1984-10-01	1989-05-29	Integrated Genetics Inc	Recombinant human tissue plasminogen activator (tpa) modified in n-linked glycosylation pattern

1984
- 1984-11-19 PT PT79518A patent/PT79518B/pt not_active IP Right Cessation
- 1984-11-19 DE DE8484810564T patent/DE3479520D1/de not_active Expired
- 1984-11-19 GR GR80966A patent/GR80966B/el unknown
- 1984-11-19 DD DD84269628A patent/DD229151A5/de not_active IP Right Cessation
- 1984-11-19 PH PH31460A patent/PH22337A/en unknown
- 1984-11-19 EP EP84810564A patent/EP0143081B1/en not_active Expired
- 1984-11-19 FI FI844544A patent/FI86746C/fi not_active IP Right Cessation
- 1984-11-20 NO NO844618A patent/NO844618L/no unknown
- 1984-11-20 NZ NZ210266A patent/NZ210266A/xx unknown
- 1984-11-20 IE IE2965/84A patent/IE57699B1/en not_active IP Right Cessation
- 1984-11-20 DK DK551084A patent/DK164941C/da not_active IP Right Cessation
- 1984-11-20 HU HU844309A patent/HU201115B/hu not_active IP Right Cessation
- 1984-11-20 AU AU35719/84A patent/AU595478B2/en not_active Ceased
- 1984-11-20 IL IL73568A patent/IL73568A/xx unknown
- 1984-11-20 JP JP59243529A patent/JPS6119489A/ja active Pending
- 1984-11-21 KR KR1019840007284A patent/KR930002889B1/ko not_active Expired - Lifetime
- 1984-11-21 ES ES537828A patent/ES8609471A1/es not_active Expired

Also Published As

Publication number	Publication date
DK551084D0 (da)	1984-11-20
NZ210266A (en)	1988-11-29
KR850003733A (ko)	1985-06-26
EP0143081A2 (en)	1985-05-29
JPS6119489A (ja)	1986-01-28
KR930002889B1 (ko)	1993-04-12
FI844544A0 (fi)	1984-11-19
IL73568A0 (en)	1985-02-28
AU3571984A (en)	1986-03-20
PT79518A (en)	1984-12-01
HUT36185A (en)	1985-08-28
NO844618L (no)	1985-05-22
DK551084A (da)	1985-05-22
FI86746B (fi)	1992-06-30
ES537828A0 (es)	1986-07-16
ES8609471A1 (es)	1986-07-16
EP0143081A3 (en)	1987-01-07
HU201115B (en)	1990-09-28
FI844544L (fi)	1985-05-22
IE842965L (en)	1985-05-21
FI86746C (fi)	1992-10-12
PH22337A (en)	1988-08-12
DE3479520D1 (en)	1989-09-28
DK164941C (da)	1993-02-01
PT79518B (pt)	1986-12-12
IE57699B1 (en)	1993-03-10
AU595478B2 (en)	1990-04-05
IL73568A (en)	1992-07-15
DK164941B (da)	1992-09-14
EP0143081B1 (en)	1989-08-23
GR80966B (en)	1985-03-15

Legal Events

Date	Code	Title	Description
1995-09-14	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DD229151A5 (de)	1985-10-30	Verfahren zur herstellung von gewebeplasminogenaktivatoren
DE3885668T2 (de)	1994-05-05	Kluyveromyces als Wirtsstamm.
DE3686136T2 (de)	1992-12-17	Fibrinolytisches agens.
DE3316297C2 (da)	1989-09-21
DE3382760T2 (de)	1995-03-02	Herstellung von funktionellen menschlichen Urokinasepolypeptiden.
DE3751128T2 (de)	1995-07-20	Rekombinante gereinigte Protease, Nexin.
DE69428719T2 (de)	2002-08-08	Für das yap3 signalpeptid kodierendes dna-konstrukt
DE3881776T2 (de)	1993-11-18	DNS-Konstruktionen, enthaltend eine Kluyveromyces-alpha-Factor-Leadersequenz zur Leitung der Sekretion von heterologen Polypeptiden.
DE68923298T2 (de)	1996-01-11	Gewebe-plasminogenaktivator mit zymogenen oder fibrinspezifischen eigenschaften.
DE68923123T2 (de)	1995-11-30	Herstellung von Proteinen.
DE69229126T2 (de)	1999-12-30	Verfahren zur Herstellung von Thrombin
DD218118A5 (de)	1985-01-30	Verfahren zur herstellung eines hefe- oder nichthefepolypeptids
EP1472346A2 (de)	2004-11-03	Verfahren zur herstellung von rekombinanten proteinen in mikroorganismen
DE3851259T2 (de)	1994-12-15	Mutierter t-PA mit Kringle-Ersatz.
DE3752008T2 (de)	1997-08-14	Hybride Plasminogenaktivatoren
DE3537176A1 (de)	1986-07-10	Expression eines plasminogenaktivators in hefe
DE3853100T2 (de)	1995-08-03	Gewebs-Plasminogen-Aktivator-Analoge mit modifizierten Wachstumsfaktordomänen.
EP0408945B1 (de)	1995-12-13	Plasmide, deren Herstellung und deren Verwendung bei der Gewinnung eines Plasminogenaktivators
DE3888386T2 (de)	1994-07-14	Verfahren zur Herstellung von Proteinen.
EP0496327B1 (de)	2001-08-16	Verfahren zur Herstellung von Polypeptiden mit Prourokinase-Aktivität
WO1996001312A1 (de)	1996-01-18	Nicht-glykosylierte plasminogenaktivator-derivate und ihre verwendung bei erhöhtem blutungsrisiko
DE3887425T2 (de)	1994-06-23	BAR1-Sekretions-Signal-Sequenz.
EP0917567A1 (de)	1999-05-26	Thrombinaktivierbarer plasminogenaktivator
JPS62500103A (ja)	1987-01-16	ヒト結合組織アクチベ−タ−及び関連ペプチドの発現
WO1987006611A1 (fr)	1987-11-05	Procede de production d'activateurs de plasminogene dans des procaryotes