DD239407A5 - Verfahren zur herstellung von statin oder derivate hiervon enthaltenden renin-inhibitoren - Google Patents

Verfahren zur herstellung von statin oder derivate hiervon enthaltenden renin-inhibitoren Download PDF

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Publication number
DD239407A5
DD239407A5 DD85274895A DD27489585A DD239407A5 DD 239407 A5 DD239407 A5 DD 239407A5 DD 85274895 A DD85274895 A DD 85274895A DD 27489585 A DD27489585 A DD 27489585A DD 239407 A5 DD239407 A5 DD 239407A5
Authority
DD
German Democratic Republic
Prior art keywords
carbon atoms
item
butyloxycarbonyl
phenylalanine
glutamic acid
Prior art date
Application number
DD85274895A
Other languages
German (de)
English (en)
Inventor
Jasjit S Bindra
Edward F Kleinman
Robert L Rosati
Original Assignee
������@���Kk��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FI850948A priority Critical patent/FI850948A7/fi
Priority to CA000476191A priority patent/CA1254699A/en
Priority to DK110285A priority patent/DK110285A/da
Priority to AU39744/85A priority patent/AU557123B2/en
Priority to PT80094A priority patent/PT80094B/pt
Priority to EG157/85A priority patent/EG17763A/xx
Priority to EP85301691A priority patent/EP0155809B1/en
Priority to JP60049216A priority patent/JPS60252495A/ja
Application filed by ������@���Kk�� filed Critical ������@���Kk��
Priority to DD85274895A priority patent/DD239407A5/de
Priority to US06/839,010 priority patent/US4749687A/en
Publication of DD239407A5 publication Critical patent/DD239407A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DD85274895A 1984-03-12 1985-04-04 Verfahren zur herstellung von statin oder derivate hiervon enthaltenden renin-inhibitoren DD239407A5 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FI850948A FI850948A7 (fi) 1984-03-12 1985-03-11 Reniinin inhibitoreja, jotka sisältävät statiinia tai sen johdannaisia.
CA000476191A CA1254699A (en) 1984-03-12 1985-03-11 Renin inhibitors containing statine or derivatives thereof
DK110285A DK110285A (da) 1984-03-12 1985-03-11 Polypeptider og polypeptidderivater indeholdende statin eller derivater deraf og farmaceutiske praeparater
AU39744/85A AU557123B2 (en) 1984-03-12 1985-03-12 Peptide renin inhibitors containing statine or derivatives thereof
PT80094A PT80094B (pt) 1984-03-12 1985-03-12 Processo para a preparacao de inibidores de renina contendo estatina ou os seus derivados
EG157/85A EG17763A (en) 1984-03-12 1985-03-12 Process for preparing delivery device for zero-ordrenin inhibitors containing statine or derivativeser release of an active principale into a dissolut thereof ion fluid
EP85301691A EP0155809B1 (en) 1984-03-12 1985-03-12 Renin inhibitors containing statine or derivatives thereof
JP60049216A JPS60252495A (ja) 1984-03-12 1985-03-12 スタチンまたはその誘導体を含有するレニン阻害剤
DD85274895A DD239407A5 (de) 1984-03-12 1985-04-04 Verfahren zur herstellung von statin oder derivate hiervon enthaltenden renin-inhibitoren
US06/839,010 US4749687A (en) 1984-03-12 1986-03-10 Renin inhibitors containing statine or derivatives thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58827984A 1984-03-12 1984-03-12
DD85274895A DD239407A5 (de) 1984-03-12 1985-04-04 Verfahren zur herstellung von statin oder derivate hiervon enthaltenden renin-inhibitoren

Publications (1)

Publication Number Publication Date
DD239407A5 true DD239407A5 (de) 1986-09-24

Family

ID=25747953

Family Applications (1)

Application Number Title Priority Date Filing Date
DD85274895A DD239407A5 (de) 1984-03-12 1985-04-04 Verfahren zur herstellung von statin oder derivate hiervon enthaltenden renin-inhibitoren

Country Status (9)

Country Link
US (1) US4749687A (da)
EP (1) EP0155809B1 (da)
JP (1) JPS60252495A (da)
AU (1) AU557123B2 (da)
CA (1) CA1254699A (da)
DD (1) DD239407A5 (da)
DK (1) DK110285A (da)
FI (1) FI850948A7 (da)
PT (1) PT80094B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
DE3438545A1 (de) * 1984-10-20 1986-04-24 Merck Patent Gmbh, 6100 Darmstadt Peptide
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
FI872890L (fi) * 1985-11-01 1987-06-30 Pfizer Polypeptider innehaollande difluorcyklostatin.
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
DE3601248A1 (de) * 1986-01-17 1987-07-23 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
DE3610593A1 (de) * 1986-03-29 1987-10-01 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
WO1988000939A1 (fr) * 1986-07-25 1988-02-11 Banyu Pharmaceutical Co., Ltd. Derives d'amino-alcools optiquement actifs et procede pour leur preparation
MY103189A (en) * 1986-10-31 1993-05-29 Pfizer Nor-statine and nor-cyclostatine polypeptides
US4927565A (en) * 1986-12-19 1990-05-22 Banyu Pharmaceutical Co., Ltd. 5-substituted amino-4-hydroxy-pentenoic acid derivatives and their use
DE3789101T2 (de) * 1986-12-19 1994-07-21 Sankyo Co Renin inhibierende Oligopeptide, ihre Präparation und ihre Anwendung.
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
US5089471A (en) * 1987-10-01 1992-02-18 G. D. Searle & Co. Peptidyl beta-aminoacyl aminodiol carbamates as anti-hypertensive agents
EP0312158A3 (en) * 1987-10-13 1990-07-25 Merck & Co. Inc. Tetrapeptide renin inhibitors having novel c-terminal amino acid amide
EP0312157A3 (en) * 1987-10-13 1990-07-25 Merck & Co. Inc. Tetrapeptide renin inhibitors having a novel c-terminal amino acid
US5034512A (en) * 1987-10-22 1991-07-23 Warner-Lambert Company Branched backbone renin inhibitors
GB8728560D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
ATE107658T1 (de) * 1988-01-26 1994-07-15 Sankyo Co Renin inhibierende polypeptide, ihre herstellung und anwendung.
US5036054A (en) * 1988-02-11 1991-07-30 Warner-Lambert Company Renin inhibitors containing alpha-heteroatom amino acids
US5126451A (en) * 1988-02-11 1992-06-30 Warner-Lambert Company Renin inhibitors containing α-heteroatom amino acids
TW225540B (da) * 1990-06-28 1994-06-21 Shionogi & Co
IL131748A0 (en) 1997-05-07 2001-03-19 Basf Ag Subtituted 2-(3-alkenyl - benzoyl) -cyclohexane- 1, 3- diones
FR2869539B1 (fr) * 2004-04-29 2008-08-08 Univ Paris Descartes Compositions pharmaceutiques pour la prevention et le traitement de l'atherosclerose
EP2113510A1 (en) * 2008-04-30 2009-11-04 Freie Universität Berlin Pepstatin A derivatives
CN104447759B (zh) * 2014-11-24 2017-05-03 吉林农业大学 一种环二肽的生产方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
JPS6010588B2 (ja) * 1979-08-01 1985-03-18 東京電力株式会社 放射能モニタリング方法
PT70158A1 (en) * 1980-03-03 1982-03-01 Univ Miami Process for preparing anti-hypertensive agents
US4609643A (en) * 1980-08-06 1986-09-02 Aktiebolaget Hassle Renin inhibitors, treatments and dipeptide synthesis
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4478826A (en) * 1981-10-08 1984-10-23 Merck & Co., Inc. Renin inhibitory peptides
CA1258748A (en) 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
US4470971A (en) * 1981-10-19 1984-09-11 Merck & Co., Inc. Renin inhibitory peptides having His13
US4397786A (en) 1981-11-23 1983-08-09 Merck & Co., Inc. Method of preparing statine and derivatives
US4479941A (en) * 1981-12-10 1984-10-30 Merck & Co., Inc. Renin inhibitory peptides having PHE13 delection
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
FR2531951A1 (fr) * 1982-08-17 1984-02-24 Sanofi Sa Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
US4650661A (en) * 1982-09-15 1987-03-17 Aktiebolaget Hassle Enzyme inhibitors
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
DE3381565D1 (de) * 1982-12-27 1990-06-21 Merck & Co Inc Reninhemmende tripeptide.
FI843837A0 (fi) * 1983-02-07 1984-09-28 Ferring Ab Enzyminhibitorer.
US4478827A (en) * 1983-05-09 1984-10-23 The General Hospital Corporation Renin inhibitors
US4455303A (en) * 1983-05-24 1984-06-19 The General Hospital Corporation Renin inhibitors
US4485099A (en) * 1983-06-15 1984-11-27 Merck & Co., Inc. Renin inhibitors containing a C-terminal amide cycle
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate

Also Published As

Publication number Publication date
FI850948L (fi) 1985-09-13
DK110285D0 (da) 1985-03-11
CA1254699A (en) 1989-05-23
AU557123B2 (en) 1986-12-04
FI850948A7 (fi) 1985-09-13
FI850948A0 (fi) 1985-03-11
PT80094B (pt) 1987-10-20
EP0155809B1 (en) 1990-05-09
EP0155809A2 (en) 1985-09-25
US4749687A (en) 1988-06-07
DK110285A (da) 1985-09-13
EP0155809A3 (en) 1987-05-27
JPS60252495A (ja) 1985-12-13
AU3974485A (en) 1985-09-19
PT80094A (en) 1985-04-01

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