DD251984A5 - Verfahren zur herstellung von 3'-azidonucleosiden und pharmazeutisch vertraeglichen derivaten davon - Google Patents

Verfahren zur herstellung von 3'-azidonucleosiden und pharmazeutisch vertraeglichen derivaten davon Download PDF

Info

Publication number: DD251984A5
Authority: DD; German Democratic Republic
Prior art keywords: formula; azido; compound; group; amino
Prior art date: 1985-09-17

Application number

DD86294404A

Other languages

German (de)

English (en)

Inventor

Janet L Rideout

David W Barry

Sandra N Lehrman

Clair Martha H St

Phillip A Furman

George A Freeman

Thomas P Zimmerman

Gerald Wolberg

De Paulo M Miranda

Sammy R Shaver

Geoffrey White

Original Assignee

The Wellcome Foundation Limited,Gb

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-09-17

Filing date

1986-09-15

Publication date

1987-12-02

1985-09-17 Priority claimed from US06/776,899 external-priority patent/US4724232A/en

1986-09-15 Application filed by The Wellcome Foundation Limited,Gb filed Critical The Wellcome Foundation Limited,Gb

1987-12-02 Publication of DD251984A5 publication Critical patent/DD251984A5/de

Links

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-1 cytidine radical Chemical class 0.000 claims description 51
239000003795 chemical substances by application Substances 0.000 claims description 36
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 28
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims description 22
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims description 21
238000006243 chemical reaction Methods 0.000 claims description 20
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DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims description 17
239000001257 hydrogen Substances 0.000 claims description 17
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 16
239000002243 precursor Substances 0.000 claims description 13
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229960000814 tetanus toxoid Drugs 0.000 description 1
VDZOOKBUILJEDG-UHFFFAOYSA-M tetrabutylammonium hydroxide Substances [OH-].CCCC[N+](CCCC)(CCCC)CCCC VDZOOKBUILJEDG-UHFFFAOYSA-M 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
208000014754 thrombocytosis disease Diseases 0.000 description 1
LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
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238000002054 transplantation Methods 0.000 description 1
125000001425 triazolyl group Chemical group 0.000 description 1
GRGCWBWNLSTIEN-UHFFFAOYSA-N trifluoromethanesulfonyl chloride Chemical compound FC(F)(F)S(Cl)(=O)=O GRGCWBWNLSTIEN-UHFFFAOYSA-N 0.000 description 1
VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
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ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
229960003414 zomepirac Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DD86294404A 1985-09-17 1986-09-15 Verfahren zur herstellung von 3'-azidonucleosiden und pharmazeutisch vertraeglichen derivaten davon DD251984A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/776,899 US4724232A (en)	1985-03-16	1985-09-17	Treatment of human viral infections

Publications (1)

Publication Number	Publication Date
DD251984A5 true DD251984A5 (de)	1987-12-02

Family

ID=25108682

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DD86294404A DD251984A5 (de)	1985-09-17	1986-09-15	Verfahren zur herstellung von 3'-azidonucleosiden und pharmazeutisch vertraeglichen derivaten davon
DD86309343A DD262802A5 (de)	1985-09-17	1986-09-15	Verfahren zur herstellung einer pharmazeutischen formulierung

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DD86309343A DD262802A5 (de)	1985-09-17	1986-09-15	Verfahren zur herstellung einer pharmazeutischen formulierung

Country Status (3)

Country	Link
JP (1)	JP2523527B2 (ja)
DD (2)	DD251984A5 (ja)
ZA (1)	ZA867013B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4916122A (en) *	1987-01-28	1990-04-10	University Of Georgia Research Foundation, Inc.	3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
DE3739366A1 (de) *	1987-04-10	1988-10-27	Boehringer Mannheim Gmbh	Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
GB8800276D0 (en) *	1988-01-07	1988-02-10	Univ Liverpool	Medical treatment
JPH02255696A (ja) *	1989-03-28	1990-10-16	Sanyo Kokusaku Pulp Co Ltd	３’―アジド―２’、３’―ジデオキシ―４―チオピリミジンヌクレオシド誘導体、その製法およびそれを用いた抗ウイルス剤
AU6630996A (en) *	1995-08-04	1997-03-05	Kobayashi Perfumery Co., Ltd.	Process for producing azido nucleoside derivatives
NZ567272A (en) *	2005-09-26	2012-02-24	Pharmasset Inc	Modified 4'-nucleosides as antiviral agents
DE102006037786A1 (de)	2006-08-11	2008-03-20	Resprotect Gmbh	Nukleoside, diese enthaltendes Arzneimittel und deren Verwendung

1986
- 1986-09-15 DD DD86294404A patent/DD251984A5/de not_active IP Right Cessation
- 1986-09-15 ZA ZA867013A patent/ZA867013B/xx unknown
- 1986-09-15 DD DD86309343A patent/DD262802A5/de not_active IP Right Cessation
- 1986-09-16 JP JP61217871A patent/JP2523527B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DD262802A5 (de)	1988-12-14
JPS62103100A (ja)	1987-05-13
JP2523527B2 (ja)	1996-08-14
ZA867013B (en)	1988-04-27

Legal Events

Date	Code	Title	Description
1999-02-04	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
CA1302263C (en)	1992-06-02	Therapeutic nucleosides
DE69933860T2 (de)	2007-05-31	2'-fluoronukleoside
DE69929060T2 (de)	2006-08-31	Beta-l-2'-deoxynukleoside für die behandlung von hepatitis b virus
DE60208794T2 (de)	2006-08-31	4'-substituierte nukleoside zur behandlung von hepatitis-c-virus-vermittelten erkrankungen
DE3650130T2 (de)	1995-03-16	Antivirale Nukleoside.
DE69318031T2 (de)	1998-09-03	Ematiomerenreine beta-d-dioxolane nucleoside mit selektiver antihepatitis b-virus wirkung
DE69232845T2 (de)	2003-04-24	1,3-Oxathiolannukleosid-analoge Verbindungen
EP0254268B2 (de)	1994-01-12	Fluorierte Nucleoside, ihre Herstellung und ihre pharmazeutische Verwendung gegen AIDS
DE69729887T2 (de)	2005-07-28	Purin-L-Nukleoside, Analoga und deren Verwendung
DE3689976T2 (de)	1995-03-16	Therapeutische Nucleoside und deren Herstellung.
DE69025529T2 (de)	1996-10-17	Weitere antivirale Pyrimidin-Nukleosiden
DE69230140T2 (de)	2000-04-06	Antivirale nucleosidkombination
DE69425574T2 (de)	2001-01-04	L-2',3'-dideoxy-nukleosidanaloga als anti-hepatitis b-(hbv) und anti-hiv-wirkstoffe
EP0484333B1 (de)	1995-11-15	Nucleosid-derivate und deren verwendung als arzneimittel
DE3854297T2 (de)	1996-03-28	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
DE60102293T2 (de)	2005-02-17	Antivirale pyrimidin-nukleosid-analogen
DD274766A5 (de)	1990-01-03	Verfahren zur herstellung einer pharmazeutischen formulierung
DD293962A5 (de)	1991-09-19	Verfahren zur herstellung einer pharmazeutischen formulierung
DE4207363A1 (de)	1993-09-09	Antivirale nucleosidanaloga, ihre herstellung und ihre pharmazeutische verwendung
DE3739366A1 (de)	1988-10-27	Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
EP0479336A1 (en)	1992-04-08	Antiviral compounds
DE3875769T2 (de)	1993-04-08	Therapeutische nukleoside.
EP0355031A2 (de)	1990-02-21	Substituierte Pyrimidinnucleoside, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
DE3854811T2 (de)	1996-08-01	Anti-HIV Pyrimidin Nucleoside
DE68914750T2 (de)	1994-10-20	Therapeutische Nucleoside.