DD257010A1 - ERGOTROPE MEDIUM - Google Patents
ERGOTROPE MEDIUM Download PDFInfo
- Publication number
- DD257010A1 DD257010A1 DD29920487A DD29920487A DD257010A1 DD 257010 A1 DD257010 A1 DD 257010A1 DD 29920487 A DD29920487 A DD 29920487A DD 29920487 A DD29920487 A DD 29920487A DD 257010 A1 DD257010 A1 DD 257010A1
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- ergotropic
- alkylamino
- hydroxy
- feed
- iso
- Prior art date
Links
- 230000002031 ergotropic effect Effects 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract description 4
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 4
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 3
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract description 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 3
- 239000001257 hydrogen Substances 0.000 claims abstract description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 3
- 150000003839 salts Chemical class 0.000 claims abstract description 3
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract description 2
- 150000003918 triazines Chemical class 0.000 abstract 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Die Erfindung betrifft neue Ergotropica fuer die Landwirtschaft, die durch einen Gehalt an Triazinderivaten der allgemeinen Formel, worin R1 und R2 unabhaengig voneinander Wasserstoff, Hydroxy-, Alkoxy, Mercapto-, Alkylmercapto-, Amino-, Alkylamino-, Dialkylamino-, R3 Alkyl- oder ggf. substituierte Arylgruppen sein koennen, und/oder ihre Salze und/oder ihre Komplexverbindungen, in Konzentrationen zwischen 0,000001 und 90%, gekennzeichnet sind. Die erfindungsgemaessen Mittel koennen in der landwirtschaftlichen Tierproduktion durch Einsparung von Futtermitteln und beschleunigte Massezunahme bei den Tieren zu einer hoeheren Wirtschaftlichkeit fuehren. Die Wirkung wird nicht durch Selektion resistenter Bakterienstaemme gefaehrdet. FormelThe invention relates to novel ergotropics for agriculture, which by a content of triazine derivatives of the general formula wherein R1 and R2 are independently hydrogen, hydroxy, alkoxy, mercapto, alkylmercapto, amino, alkylamino, dialkylamino, R3 alkyl or optionally substituted aryl groups, and / or their salts and / or their complex compounds, in concentrations between 0.000001 and 90%, are characterized. The agents according to the invention can lead to a higher economic efficiency in the agricultural animal production by saving of animal feed and accelerated mass increase with the animals. The effect is not endangered by the selection of resistant bacteria. formula
Description
Die Erfindung betrifft neue ergotrope Mittel, die geeignet sind, die Wirtschaftlichkeit der landwirtschaftlichen Tierproduktion durch Beschleunigung der Massezunahme und/oder durch höhere Ausnutzung der Futtermittel zu verbessern.The invention relates to new ergotropic means which are suitable for improving the profitability of agricultural animal production by accelerating the increase in mass and / or by making greater use of the feed.
Die meisten bekannten Ergotropika beruhen auf einer milden antibiotischen Wirkung. So kann zum Beispiel durch Bekämpfung von Methanbakterien, die einen Teil der Futterstoffe in Methan umwandeln und dadurch der Verwertung im tierischen Organismus entziehen, eine bessere Futterverwertung und beschleunigte Mast erreicht werden. Ein Nachteil dieser antimikribiell wirkenden Ergotropika besteht jedoch darin, daß die Wirkung nach einiger Zeit durch Selektion resistenter Bakterienstämme nachläßt. Außerdem ist es bei antibakteriell wirkender Ergotropika möglich, daß im Sinne einer Kreuzresistenz die Anwendbarkeit von anderen Antibiotika in der Human- und Veterinärmedizin gefährdet wird.Most known ergotropics are based on a mild antibiotic effect. For example, better control of feed conversion and accelerated fattening can be achieved by controlling methane bacteria, which convert part of the feed into methane and thereby deprive it of use in the animal organism. A disadvantage of these antimicrobial ergotropics, however, is that the effect diminishes after some time by selecting resistant bacterial strains. In addition, it is possible with antibacterial ergotropics that in the interest of cross-resistance, the applicability of other antibiotics in human and veterinary medicine is at risk.
Ziel der ErfindungObject of the invention
Das Ziel der Erfindung besteht darin, daß neue ergotrope Mittel mit anderen als antimikrobiellen Wirkungsmechanismen aufgezeigt werden sollen.The object of the invention is to demonstrate new ergotropic agents with other than antimicrobial mechanisms of action.
DerErfindung liegt die Aufgabe zugrunde, neue Ergotropika aufzuzeigen, deren Wirkung nicht durch Selektion resistenter Bakterienstämme gefährdet ist.The invention is based on the object to show new ergotropics whose effect is not endangered by selection of resistant strains of bacteria.
Diese Aufgabe wird überraschend dadurch gelöst, daß Verbindungen der allgemeinen Formel IThis object is surprisingly achieved in that compounds of the general formula I.
R1 und R2 unabhängig voneinander Wasserstoff, Hydroxy-, Alkoxy-, Mercapto-, Alkylmercapto-, Amino-, Alkylamino-, Dialkylämino-,R 1 and R 2 independently of one another are hydrogen, hydroxyl, alkoxy, mercapto, alkylmercapto, amino, alkylamino, dialkylamino,
R3 Alkyl-oder ggf. substituierte Arylgruppen sein können und/oder ihre Salze und/oder ihre Komplexverbindungen in Konzentrationen zwischen 0,000001 und 95%, vorzugsweise zwischen 0,00001 und 90%, enthalten sind.R 3 may be alkyl or optionally substituted aryl groups and / or their salts and / or their complex compounds in concentrations between 0.000001 and 95%, preferably between 0.00001 and 90%, are included.
R(DR (D
R (2)R (2)
9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19.9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19.
-NH-C2H5 -NH-C 2 H 5
-NH-C3H7(ISO)-NH-C 3 H 7 (ISO)
-NH-C3H7(ISo)-NH-C 3 H 7 (ISo)
-NH-C3H7(ISo)-NH-C 3 H 7 (ISo)
-NH-C3H7(ISo)-NH-C 3 H 7 (ISo)
-NH-C3H7(ISO)-NH-C 3 H 7 (ISO)
-NH-C3H7(ISO)-NH-C 3 H 7 (ISO)
-NH-(CH2J3OCH3 -NH- (CH 2 J 3 OCH 3
-NH-(C2H5)-NH- (C 2 H 5 )
-NH-CH3 -NH-CH 3
-NH-C2H5 -NH-C 2 H 5
-NH-C4Hg(tert) -NH-C 4 H g (tert)
-NH-C„H9(tert)-NH-C "H 9 (tert)
-NH-C4H9(tert)-NH-C 4 H 9 (tert)
-NH-C4H9(tert)-NH-C 4 H 9 (tert)
-NH-C4J9(tert)-NH-C 4 J 9 (tert)
-NH-C3H7(ISo)-NH-C 3 H 7 (ISo)
-NH-C4H9(tert)-NH-C 4 H 9 (tert)
-NH-(C2H6)-NH- (C 2 H 6 )
-C2H5 -C 2 H 5
-C2H5 -C 2 H 5
-C3H7(ISo)-C 3 H 7 (ISo)
-CH3 -CH 3
-C3H7(ISO)-C 3 H 7 (ISO)
-(CH2J3-OCH3 - (CH 2 J 3 -OCH 3
-(CH2)3-OCH3 - (CH 2 ) 3 -OCH 3
-C2H5 -C 2 H 5
-CH3 -CH 3
-CH3 -CH 3
-CH3 -CH 3
-C2H5 -C 2 H 5
-C3H7(JSO)-C 3 H 7 (JSO)
-C3H7(n)-C 3 H 7 (n)
-C4Hg(tert)-C 4 Hg (tert)
-OH -OH -OH -OH -OH -OH -OH -OH -OH -OH -OH -OH -OH -OH -OH -OH -OH -OH -OH-OH -OH-OH-OH-OH-OH-OH-OH-OH-OH-OH-OH-OH-OH-OH-OH-OH
Die besonders bevorzugten Verbindungen sind bekannt und können nach bekannten Verfahren hergestellt werden. Erfindungsgemäß können sie in Reinsubstanz als ergotrope Mittel angewendet oder zuvor mit üblichen festen oder flüssigen Trägerstoffen und ggf. weiteren Zuschlagstoffen in eine für die Anwendung geeignetere Form gebracht werden. Die Applikation erfolgt in den tierischen Organismus oder durch Behandlung des Lebensraumes der Tiere. Besonderts bevorzugt ist die orale Applikation in Form von Lösungen, Suspensionen oder Pulverpräparaten gleichzeitig mit dem Futter und/oder Trinkwasser und/oder die Applikation'über Schleimhäute.The most preferred compounds are known and can be prepared by known methods. According to the invention, they can be used in pure form as ergotropic agents or be previously brought in a form suitable for the application with conventional solid or liquid carriers and optionally further additives. The application takes place in the animal organism or by treatment of the habitat of the animals. Particularly preferred is the oral administration in the form of solutions, suspensions or powder preparations simultaneously with the feed and / or drinking water and / or the Anwendung'über mucous membranes.
Zur Erweiterung des Wirkungsspektrums können die erfindungsgemäßen Mittel mit weiteren biologisch aktiven Stoffen vermischt und gemeinsam mit diesen angewendet werden, so z. B. mit Arzneimitteln, mineralischen und/oder organischen Nährstoffen bzw. Futtermitteln und/oder Hormonen und/oder Vitaminen.To extend the spectrum of action agents of the invention may be mixed with other biologically active substances and used together with these, such. As with drugs, mineral and / or organic nutrients or feed and / or hormones and / or vitamins.
Anwendungsbeispieleapplications
Zum Nachweis der ergotropen Wirkung der erfindungsgemäßen Mittel wurden Fütterungsversuche mit 6-Oxy-2-ethylamino-4-isopropylamino-[1,3,5]triazin (Verbindung 2 der aufgelisteten bevorzugten Verbindungen) an wachsenden männlichen Ratten durchgeführt.To demonstrate the ergotropic effect of the agents according to the invention, feeding experiments with 6-oxy-2-ethylamino-4-isopropylamino- [1,3,5] triazine (compound 2 of the preferred compounds listed) were carried out on growing male rats.
Es wurden Wistar-Ratten (Herkunft Schönwalde) verwendet. Das erfindungsgemäße Mittel wurde in Form seines Hydrochlorids in einer Konzentration von 0,005μg/ml in einer 200-ml-Trinkflasche ad libitum bereitgestellt. Die durchschnittliche FlüssigkeitsaufnahmeTier/d betrug 23,4ml.Wistar rats (origin Schönwalde) were used. The composition according to the invention was provided in the form of its hydrochloride in a concentration of 0.005 μg / ml in a 200 ml bottle ad libitum. The average fluid intake animal / d was 23.4 ml.
Die Kontrolltiere erhielten ebenfalls Wasser ad libitum. In beiden Gruppen betrug der Futterverbrauch 20,5g/d/Tier.The control animals also received water ad libitum. In both groups the feed consumption was 20.5g / d / animal.
Anfangsgewichtinitial weight
EndgewichtFinal weight
Zunahme(g)Increase (g)
Mittel 71Mean 71
Kontrolle - 79Control - 79
(n = 10, Zunahme zur Kontrolle 8,7%)(n = 10, increase to control 8.7%)
195 193195 193
124 114124 114
Claims (1)
2. Ergotrope Mittel nach Anspruch 1, dadurch gekennzeichnet, daß R1 eine Alkylamino-, R2 eine0.00001 and 90%, are included.
2. Ergotropic agent according to claim 1, characterized in that R 1 is an alkylamino, R 2 is a
3l Ergotrope Mittel nach Anspruch 1 bis 2, dadurch gekennzeichnet, daß zusätzlich Futtermittel,Hydroxy and R 3 is an alkyl group.
3l Ergotropic agent according to claim 1 to 2, characterized in that additionally feed,
4. Ergotrope Mittel, nach Anspruch 1 bis 3, dadurch gekennzeichnet, daß Vormischungen bzw. Futtermittelmischungen verwendet werden.Vitamins, minerals and / or active ingredients are included.
4. Ergotropic agent, according to claim 1 to 3, characterized in that premixes or feed mixtures are used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD29920487A DD257010A1 (en) | 1987-01-13 | 1987-01-13 | ERGOTROPE MEDIUM |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD29920487A DD257010A1 (en) | 1987-01-13 | 1987-01-13 | ERGOTROPE MEDIUM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD257010A1 true DD257010A1 (en) | 1988-06-01 |
Family
ID=5586312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD29920487A DD257010A1 (en) | 1987-01-13 | 1987-01-13 | ERGOTROPE MEDIUM |
Country Status (1)
| Country | Link |
|---|---|
| DD (1) | DD257010A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2804113A1 (en) * | 2000-01-26 | 2001-07-27 | Lipha | New 2,4-diamino-3,6-dihydro-1,3,5-triazine derivatives, useful for treating disorders associated with insulin resistance syndrome, e.g. diabetes, dislipidemia, obesity or arterial hypertension |
-
1987
- 1987-01-13 DD DD29920487A patent/DD257010A1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2804113A1 (en) * | 2000-01-26 | 2001-07-27 | Lipha | New 2,4-diamino-3,6-dihydro-1,3,5-triazine derivatives, useful for treating disorders associated with insulin resistance syndrome, e.g. diabetes, dislipidemia, obesity or arterial hypertension |
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