DD258992A1 - Verfahren zum gleichzeitigen trocknen und granulieren von extaktstoffen aus enteiweissten kaelberblut - Google Patents

Verfahren zum gleichzeitigen trocknen und granulieren von extaktstoffen aus enteiweissten kaelberblut Download PDF

Info

Publication number: DD258992A1
Authority: DD; German Democratic Republic
Prior art keywords: fluidized bed; extractives; granules; weight; temperature
Prior art date: 1985-10-04

Application number

DD86295006A

Other languages

German (de)

English (en)

Inventor

Otto Klug

Heinrich Schluenken

Dietmar Siegel

Original Assignee

Hormon Chemie Muenchen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-04

Filing date

1986-10-03

Publication date

1988-08-10

1986-10-03 Application filed by Hormon Chemie Muenchen filed Critical Hormon Chemie Muenchen

1988-08-10 Publication of DD258992A1 publication Critical patent/DD258992A1/de

Links

238000000034 method Methods 0.000 title claims abstract description 38
238000001035 drying Methods 0.000 title claims abstract description 13
239000008280 blood Substances 0.000 title claims abstract description 12
210000004369 blood Anatomy 0.000 title claims abstract description 12
238000005469 granulation Methods 0.000 title description 6
230000003179 granulation Effects 0.000 title description 6
238000012656 cationic ring opening polymerization Methods 0.000 title 1
239000008187 granular material Substances 0.000 claims abstract description 69
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
239000007864 aqueous solution Substances 0.000 claims abstract description 21
238000005507 spraying Methods 0.000 claims abstract description 19
239000000945 filler Substances 0.000 claims abstract description 17
239000011230 binding agent Substances 0.000 claims abstract description 16
244000309466 calf Species 0.000 claims abstract description 14
239000000969 carrier Substances 0.000 claims abstract description 13
239000000243 solution Substances 0.000 claims description 23
238000002360 preparation method Methods 0.000 claims description 14
239000007909 solid dosage form Substances 0.000 claims description 12
239000007921 spray Substances 0.000 claims description 12
239000000203 mixture Substances 0.000 claims description 10
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
239000008108 microcrystalline cellulose Substances 0.000 claims description 8
235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
229920000642 polymer Polymers 0.000 claims description 5
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
238000011084 recovery Methods 0.000 claims description 5
229920002785 Croscarmellose sodium Polymers 0.000 claims description 4
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 4
239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims description 4
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 4
238000010924 continuous production Methods 0.000 claims description 3
239000000546 pharmaceutical excipient Substances 0.000 claims description 3
238000007493 shaping process Methods 0.000 claims description 3
239000000825 pharmaceutical preparation Substances 0.000 claims description 2
239000004480 active ingredient Substances 0.000 claims 1
239000000126 substance Substances 0.000 abstract description 13
239000000463 material Substances 0.000 abstract description 12
239000000284 extract Substances 0.000 abstract description 10
238000007906 compression Methods 0.000 abstract description 3
230000006835 compression Effects 0.000 abstract description 3
239000007787 solid Substances 0.000 abstract description 3
239000003814 drug Substances 0.000 abstract 2
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 12
239000003570 air Substances 0.000 description 10
238000005054 agglomeration Methods 0.000 description 9
230000002776 aggregation Effects 0.000 description 9
239000007789 gas Substances 0.000 description 9
238000004519 manufacturing process Methods 0.000 description 8
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
238000002845 discoloration Methods 0.000 description 5
239000008298 dragée Substances 0.000 description 5
238000004108 freeze drying Methods 0.000 description 5
239000000454 talc Substances 0.000 description 5
229910052623 talc Inorganic materials 0.000 description 5
239000000654 additive Substances 0.000 description 3
238000001704 evaporation Methods 0.000 description 3
239000012530 fluid Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
238000002156 mixing Methods 0.000 description 3
230000002572 peristaltic effect Effects 0.000 description 3
239000000843 powder Substances 0.000 description 3
230000002035 prolonged effect Effects 0.000 description 3
238000003860 storage Methods 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
206010052428 Wound Diseases 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
238000005299 abrasion Methods 0.000 description 2
239000013543 active substance Substances 0.000 description 2
239000003918 blood extract Substances 0.000 description 2
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
230000000694 effects Effects 0.000 description 2
230000035876 healing Effects 0.000 description 2
239000011777 magnesium Substances 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
239000003232 water-soluble binding agent Substances 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
239000003463 adsorbent Substances 0.000 description 1
239000012080 ambient air Substances 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000017531 blood circulation Effects 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
238000007908 dry granulation Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
229910021485 fumed silica Inorganic materials 0.000 description 1
239000008103 glucose Substances 0.000 description 1
150000002314 glycerols Chemical class 0.000 description 1
FETSQPAGYOVAQU-UHFFFAOYSA-N glyceryl palmitostearate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O FETSQPAGYOVAQU-UHFFFAOYSA-N 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
150000002605 large molecules Chemical class 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
208000030159 metabolic disease Diseases 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
238000010926 purge Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000008646 thermal stress Effects 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Developmental Biology & Embryology (AREA)
Immunology (AREA)
Virology (AREA)
Zoology (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

DD86295006A 1985-10-04 1986-10-03 Verfahren zum gleichzeitigen trocknen und granulieren von extaktstoffen aus enteiweissten kaelberblut DD258992A1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19853535536 DE3535536A1 (de)	1985-10-04	1985-10-04	Verfahren zum gleichzeitigen trocknen und granulieren von extraktstoffen aus enteiweisstem kaelberblut

Publications (1)

Publication Number	Publication Date
DD258992A1 true DD258992A1 (de)	1988-08-10

Family

ID=6282808

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD86295006A DD258992A1 (de)	1985-10-04	1986-10-03	Verfahren zum gleichzeitigen trocknen und granulieren von extaktstoffen aus enteiweissten kaelberblut

Country Status (16)

Country	Link
US (1)	US4753803A (fr)
EP (1)	EP0223033B1 (fr)
JP (1)	JPH0717512B2 (fr)
AT (1)	ATE65026T1 (fr)
BG (1)	BG49498A3 (fr)
CA (1)	CA1268706A (fr)
CS (1)	CS261898B2 (fr)
DD (1)	DD258992A1 (fr)
DE (2)	DE3535536A1 (fr)
DK (1)	DK167843B1 (fr)
ES (1)	ES2038587T3 (fr)
GR (1)	GR3002290T3 (fr)
HU (1)	HU196712B (fr)
PL (1)	PL148336B1 (fr)
SU (1)	SU1743334A3 (fr)
YU (1)	YU44931B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5017383A (en) *	1989-08-22	1991-05-21	Taisho Pharmaceutical Co., Ltd.	Method of producing fine coated pharmaceutical preparation
DE4441167C1 (de) *	1994-11-18	1996-03-14	Fraunhofer Ges Forschung	Verfahren zur Trocknung von Blutplasma
US6083532A (en) *	1995-03-01	2000-07-04	Duramed Pharmaceuticals, Inc.	Sustained release formulation containing three different types of polymers and tablet formed therefrom
AU754458B2 (en) *	1998-12-23	2002-11-14	Csl Behring Gmbh	Fibrin-based glue granulate and corresponding production method
TWI332400B (en) *	2001-12-14	2010-11-01	Solvay Pharm Gmbh	Preformulation for the tableting of natural mixtures of conjugated estrogens
TWI252111B (en) *	2001-12-14	2006-04-01	Solvay Pharm Gmbh	Matrix film tablet with controlled release of a natural mixture of conjugated estrogens
DE102008014237A1 (de) *	2008-03-14	2009-09-17	J. Rettenmaier & Söhne Gmbh + Co. Kg	Direktverpressbares Tablettierhilfsmittel

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1076888B (de) *	1956-12-18	1960-03-03	Karl Heinz Jaeger Dr Med	Verfahren zur Gewinnung atmungsfoerdernder Wirkstoffe fuer therapeutische Zwecke
US3458622A (en) *	1967-04-07	1969-07-29	Squibb & Sons Inc	Controlled release tablet
DE2143519B2 (de) *	1971-08-31	1974-05-30	Sandoz Ag, 8500 Nuernberg	Verfahren zur Wirbelschichtgranulation pulverförmiger pharmazeutischer Mischungen
AT330953B (de) *	1972-11-16	1976-07-26	Solco Basel Ag	Verfahren zur herstellung eines pharmazeutischen praparates zur verbesserung der zellatmung
DE3237303A1 (de) *	1982-10-08	1984-04-12	Glatt GmbH, 7851 Binzen	Vorrichtung fuer wirbelschichtverfahren sowie damit durchfuehrbares verfahren
EP0106309A3 (fr) *	1982-10-12	1986-12-30	Kailash Kumar Dr. Prof. Gauri	Extraits biologiquement actifs, procédé pour leur obtention, agents pharmaceutiques et cosmétiques les contenant et leur utilisation comme additifs pour des produits alimentaires et stimulants
US4662880A (en) *	1986-03-14	1987-05-05	Alza Corporation	Pseudoephedrine, brompheniramine therapy

1985
- 1985-10-04 DE DE19853535536 patent/DE3535536A1/de not_active Withdrawn
1986
- 1986-09-29 US US06/913,152 patent/US4753803A/en not_active Expired - Lifetime
- 1986-09-30 CA CA000519455A patent/CA1268706A/fr not_active Expired - Lifetime
- 1986-10-01 YU YU1694/86A patent/YU44931B/xx unknown
- 1986-10-02 BG BG076611A patent/BG49498A3/xx unknown
- 1986-10-02 CS CS867084A patent/CS261898B2/cs not_active IP Right Cessation
- 1986-10-03 JP JP61234731A patent/JPH0717512B2/ja not_active Expired - Fee Related
- 1986-10-03 ES ES198686113714T patent/ES2038587T3/es not_active Expired - Lifetime
- 1986-10-03 DE DE8686113714T patent/DE3680183D1/de not_active Expired - Lifetime
- 1986-10-03 DD DD86295006A patent/DD258992A1/de not_active IP Right Cessation
- 1986-10-03 SU SU864028373A patent/SU1743334A3/ru active
- 1986-10-03 PL PL1986261696A patent/PL148336B1/pl unknown
- 1986-10-03 EP EP86113714A patent/EP0223033B1/fr not_active Expired - Lifetime
- 1986-10-03 AT AT86113714T patent/ATE65026T1/de not_active IP Right Cessation
- 1986-10-03 DK DK472886A patent/DK167843B1/da not_active IP Right Cessation
- 1986-10-03 HU HU864180A patent/HU196712B/hu unknown
1991
- 1991-07-11 GR GR91400332T patent/GR3002290T3/el unknown

Also Published As

Publication number	Publication date
GR3002290T3 (en)	1992-12-30
HUT42328A (en)	1987-07-28
CS708486A2 (en)	1988-06-15
DE3535536A1 (de)	1987-04-09
DE3680183D1 (de)	1991-08-14
CA1268706A (fr)	1990-05-08
US4753803A (en)	1988-06-28
EP0223033A3 (en)	1988-06-29
EP0223033A2 (fr)	1987-05-27
PL148336B1 (en)	1989-10-31
CS261898B2 (en)	1989-02-10
EP0223033B1 (fr)	1991-07-10
HU196712B (en)	1989-01-30
YU169486A (en)	1987-12-31
BG49498A3 (en)	1991-11-15
PL261696A1 (en)	1988-01-07
YU44931B (en)	1991-04-30
DK472886A (da)	1987-04-05
ATE65026T1 (de)	1991-07-15
SU1743334A3 (ru)	1992-06-23
JPH0717512B2 (ja)	1995-03-01
JPS6287518A (ja)	1987-04-22
DK167843B1 (da)	1993-12-27
ES2038587T3 (es)	1993-08-01
DK472886D0 (da)	1986-10-03

Legal Events

Date	Code	Title	Description
1996-09-12	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
DE2950977C2 (fr)	1987-11-05
AT394310B (de)	1992-03-10	Verfahren zur herstellung lagerstabiler, schnellzerfallender pharmazeutischer wirkstoff-presslinge
DE69704426T2 (de)	2001-11-15	Verfahren zur herstellung von medizinischem kaugummi mit einem guten geschmack, enthaltend eine einschlussverbindung
DE69233239T2 (de)	2004-08-19	Pharmazeutische Granulate mit intragranularem Sprengmittel
EP0078430B1 (fr)	1986-04-23	Procédé de fabrication de préparations pharmaceutiques solides à libération rapide de dihydropyridines
DE69802543T3 (de)	2013-07-04	Verbesserte multipartikel-tablette mit schnellauflösbarkeit
DE60008912T2 (de)	2004-08-19	Direktverpressbare, ultrafeine acetaminophenzusammensetzungen und verfahren zu ihrer herstellung
EP0122574B1 (fr)	1986-10-29	Pastille divisible à libération retardée de l'ingrédient actif et procédé pour la fabrication de celle-ci
EP0108898B1 (fr)	1986-08-20	Formes galéniques orales de mopidamol
DE69326163T2 (de)	2000-05-04	Verfahren zur herstellung von arzneiformen und kontrollierte freigabe und die soerhaltenen arzneiformen
EP0232277B1 (fr)	1990-01-17	Preparations pharmaceutiques sous forme de granules ou pilules instantanes, et procede de fabrication
DE69518820T2 (de)	2001-02-22	Rotogranulat und Beschichtung von Acetaminophen, Pseudoephedrin, Chlorpheniramin und, gegebenenfalls, Dextromethorphan
DE69110592T2 (de)	1995-12-21	Pharmazeutische Zubereitung mit verbessertem Geschmack, poröse Partikel enthaltend, und deren Herstellungsmethode.
EP0173210A2 (fr)	1986-03-05	Préparation sous forme de pellet
EP0068191A2 (fr)	1983-01-05	Formes orales du dipyridamole
EP0793958A2 (fr)	1997-09-10	Procédé de préparation d'un composition contenant du fénofibrate
DE2813146A1 (de)	1978-10-19	Tablettieren von mikrokapseln
DE1292783B (de)	1969-04-17	Verfahren zum Herstellen einer Tablette mit Depotwirkung
DE4444052A1 (de)	1996-06-13	Pharmazeutische, oral anwendbare Zubereitung
DE69306243T2 (de)	1997-03-20	Zusammensetzungen mit verzögerter wirkstoffabgabe
EP0223033B1 (fr)	1991-07-10	Procédé pour le séchage et la granulation simultanés d'extraits du sang de veau déprotéiné, granulé obtenu par ce procédé et son utilisation pour la fabrication de préparations pharmaceutiques
DE1935879A1 (de)	1970-01-22	Pharmazeutisches Praeparat und Verfahren zur Herstellung von diesem
EP0164571B1 (fr)	1990-06-27	Formes retard du alpha-(2,5-diméthoxy phényl)-bêta-glycinamidoéthanol et procédé pour leur fabrication
DE3142853A1 (de)	1983-05-11	Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung
EP0116358B1 (fr)	1988-04-27	Complexes de prostaglandines