DD262802A5 - Verfahren zur herstellung einer pharmazeutischen formulierung - Google Patents

Verfahren zur herstellung einer pharmazeutischen formulierung Download PDF

Info

Publication number: DD262802A5
Authority: DD; German Democratic Republic
Prior art keywords: formula; azido; compound; active ingredient; pharmaceutically acceptable
Prior art date: 1985-09-17

Application number

DD86309343A

Other languages

German (de)

English (en)

Inventor

Janet L Rideout

David W Barry

Sandra N Lehrman

Clair Martha H St

Phillip A Furman

George A Freeman

Thomas P Zimmerman

Gerald Wolberg

Paulo M De Miranda

Sammy R Shaver

Geoffrey White

Original Assignee

The Wellcome Foundation Limited,Gb

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-09-17

Filing date

1986-09-15

Publication date

1988-12-14

1985-09-17 Priority claimed from US06/776,899 external-priority patent/US4724232A/en

1986-09-15 Application filed by The Wellcome Foundation Limited,Gb filed Critical The Wellcome Foundation Limited,Gb

1988-12-14 Publication of DD262802A5 publication Critical patent/DD262802A5/de

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 9
238000004519 manufacturing process Methods 0.000 title 1
239000004480 active ingredient Substances 0.000 claims abstract description 102
238000000034 method Methods 0.000 claims abstract description 61
230000008569 process Effects 0.000 claims abstract description 10
238000002360 preparation method Methods 0.000 claims abstract description 9
150000001875 compounds Chemical class 0.000 claims description 139
229910052739 hydrogen Inorganic materials 0.000 claims description 102
-1 hydroxy , Mercapto, amino Chemical group 0.000 claims description 53
239000003795 chemical substances by application Substances 0.000 claims description 32
125000000217 alkyl group Chemical group 0.000 claims description 21
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 21
102000014150 Interferons Human genes 0.000 claims description 17
108010050904 Interferons Proteins 0.000 claims description 17
229940079322 interferon Drugs 0.000 claims description 17
239000001257 hydrogen Substances 0.000 claims description 16
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 15
125000003545 alkoxy group Chemical group 0.000 claims description 14
229960004150 aciclovir Drugs 0.000 claims description 13
238000006243 chemical reaction Methods 0.000 claims description 13
KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims description 12
125000003282 alkyl amino group Chemical group 0.000 claims description 12
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims description 10
239000002243 precursor Substances 0.000 claims description 10
125000004093 cyano group Chemical group *C#N 0.000 claims description 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
125000004414 alkyl thio group Chemical group 0.000 claims description 8
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 8
150000002431 hydrogen Chemical class 0.000 claims description 8
125000000623 heterocyclic group Chemical group 0.000 claims description 7
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 6
125000003342 alkenyl group Chemical group 0.000 claims description 6
230000000925 erythroid effect Effects 0.000 claims description 6
229940104230 thymidine Drugs 0.000 claims description 6
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims description 5
125000000304 alkynyl group Chemical group 0.000 claims description 5
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims description 5
125000002252 acyl group Chemical group 0.000 claims description 4
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims description 4
125000004663 dialkyl amino group Chemical group 0.000 claims description 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
125000005017 substituted alkenyl group Chemical group 0.000 claims description 3
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BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 3
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ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 13
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 13
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IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 8
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OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
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LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DD86309343A 1985-09-17 1986-09-15 Verfahren zur herstellung einer pharmazeutischen formulierung DD262802A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/776,899 US4724232A (en)	1985-03-16	1985-09-17	Treatment of human viral infections

Publications (1)

Publication Number	Publication Date
DD262802A5 true DD262802A5 (de)	1988-12-14

Family

ID=25108682

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DD86309343A DD262802A5 (de)	1985-09-17	1986-09-15	Verfahren zur herstellung einer pharmazeutischen formulierung
DD86294404A DD251984A5 (de)	1985-09-17	1986-09-15	Verfahren zur herstellung von 3'-azidonucleosiden und pharmazeutisch vertraeglichen derivaten davon

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DD86294404A DD251984A5 (de)	1985-09-17	1986-09-15	Verfahren zur herstellung von 3'-azidonucleosiden und pharmazeutisch vertraeglichen derivaten davon

Country Status (3)

Country	Link
JP (1)	JP2523527B2 (ja)
DD (2)	DD262802A5 (ja)
ZA (1)	ZA867013B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4916122A (en) *	1987-01-28	1990-04-10	University Of Georgia Research Foundation, Inc.	3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
DE3739366A1 (de) *	1987-04-10	1988-10-27	Boehringer Mannheim Gmbh	Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
GB8800276D0 (en) *	1988-01-07	1988-02-10	Univ Liverpool	Medical treatment
JPH02255696A (ja) *	1989-03-28	1990-10-16	Sanyo Kokusaku Pulp Co Ltd	３’―アジド―２’、３’―ジデオキシ―４―チオピリミジンヌクレオシド誘導体、その製法およびそれを用いた抗ウイルス剤
WO1997006179A1 (en) *	1995-08-04	1997-02-20	Kobayashi Perfumery Co., Ltd.	Process for producing azido nucleoside derivatives
EA200800932A1 (ru)	2005-09-26	2008-10-30	Фармассет, Инк.	Модифицированные 4`-нуклеозиды в качестве противовирусных агентов
DE102006037786A1 (de) *	2006-08-11	2008-03-20	Resprotect Gmbh	Nukleoside, diese enthaltendes Arzneimittel und deren Verwendung

1986
- 1986-09-15 DD DD86309343A patent/DD262802A5/de not_active IP Right Cessation
- 1986-09-15 DD DD86294404A patent/DD251984A5/de not_active IP Right Cessation
- 1986-09-15 ZA ZA867013A patent/ZA867013B/xx unknown
- 1986-09-16 JP JP61217871A patent/JP2523527B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2523527B2 (ja)	1996-08-14
DD251984A5 (de)	1987-12-02
JPS62103100A (ja)	1987-05-13
ZA867013B (en)	1988-04-27

Legal Events

Date	Code	Title	Description
1999-02-04	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
CA1302263C (en)	1992-06-02	Therapeutic nucleosides
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DE69318031T2 (de)	1998-09-03	Ematiomerenreine beta-d-dioxolane nucleoside mit selektiver antihepatitis b-virus wirkung
EP0254268B2 (de)	1994-01-12	Fluorierte Nucleoside, ihre Herstellung und ihre pharmazeutische Verwendung gegen AIDS
US5646125A (en)	1997-07-08	Polysubstituted benzimidazoles as antiviral agents
DE3650130T2 (de)	1995-03-16	Antivirale Nukleoside.
DE69806919T2 (de)	2003-02-27	Antivirale pyrimidin-nukleosid-analogen
DE60102293T2 (de)	2005-02-17	Antivirale pyrimidin-nukleosid-analogen
DD293962A5 (de)	1991-09-19	Verfahren zur herstellung einer pharmazeutischen formulierung
MXPA97002932A (en)	1998-04-01	L-ribofuranosilnucleosi
WO1991001325A1 (de)	1991-02-07	Nucleosid-derivate und deren verwendung als arzneimittel
DE4207363A1 (de)	1993-09-09	Antivirale nucleosidanaloga, ihre herstellung und ihre pharmazeutische verwendung
DE68922235T2 (de)	1995-08-31	Durch Acetylen, Cyan oder Allen substituierte Aristeromycin- oder Adenosin-Derivate.
DE3855470T2 (de)	1997-03-13	Aristeromycin/Adenosin-Derivate
JP2001131075A (ja)	2001-05-15	抗ｈｉｖ剤
DE3875769T2 (de)	1993-04-08	Therapeutische nukleoside.
DE3854811T2 (de)	1996-08-01	Anti-HIV Pyrimidin Nucleoside
DE69431304T2 (de)	2003-05-15	Nukleoside und nukleotide mit vergrösserten ringen
DE68914750T2 (de)	1994-10-20	Therapeutische Nucleoside.