DD265336A5 - Verfahren und vorrichtung zum granulieren und granuliertes produkt - Google Patents
Verfahren und vorrichtung zum granulieren und granuliertes produkt Download PDFInfo
- Publication number
- DD265336A5 DD265336A5 DD87300665A DD30066587A DD265336A5 DD 265336 A5 DD265336 A5 DD 265336A5 DD 87300665 A DD87300665 A DD 87300665A DD 30066587 A DD30066587 A DD 30066587A DD 265336 A5 DD265336 A5 DD 265336A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- feedstock
- distributor device
- substance
- distributor
- peripheral portions
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 44
- 239000000126 substance Substances 0.000 claims abstract description 63
- 239000002245 particle Substances 0.000 claims abstract description 58
- 238000002844 melting Methods 0.000 claims abstract description 57
- 230000008018 melting Effects 0.000 claims abstract description 56
- 239000011230 binding agent Substances 0.000 claims abstract description 24
- 230000002093 peripheral effect Effects 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 239000004744 fabric Substances 0.000 claims abstract description 15
- 239000011159 matrix material Substances 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims description 27
- 239000008187 granular material Substances 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 15
- 238000009826 distribution Methods 0.000 claims description 13
- RGHAZVBIOOEVQX-UHFFFAOYSA-N Metoprolol succinate Chemical compound OC(=O)CCC(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 RGHAZVBIOOEVQX-UHFFFAOYSA-N 0.000 claims description 9
- 229960000939 metoprolol succinate Drugs 0.000 claims description 9
- 239000007858 starting material Substances 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 7
- 230000001965 increasing effect Effects 0.000 claims description 7
- 230000002411 adverse Effects 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 5
- 239000000155 melt Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000001993 wax Substances 0.000 claims description 5
- 239000003925 fat Substances 0.000 claims description 3
- 230000006698 induction Effects 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 229910021538 borax Inorganic materials 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 2
- 239000004328 sodium tetraborate Substances 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 150000003626 triacylglycerols Chemical class 0.000 claims description 2
- URFIUJMADXJBKL-UHFFFAOYSA-N benzoic acid;1-(propan-2-ylamino)-3-(2-prop-2-enylphenoxy)propan-2-ol Chemical compound OC(=O)C1=CC=CC=C1.CC(C)NCC(O)COC1=CC=CC=C1CC=C URFIUJMADXJBKL-UHFFFAOYSA-N 0.000 claims 3
- 239000013618 particulate matter Substances 0.000 claims 3
- 238000007599 discharging Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 description 28
- 239000007787 solid Substances 0.000 description 24
- 238000005469 granulation Methods 0.000 description 14
- 230000003179 granulation Effects 0.000 description 14
- 230000008569 process Effects 0.000 description 14
- 238000001816 cooling Methods 0.000 description 10
- 238000012545 processing Methods 0.000 description 9
- 230000015556 catabolic process Effects 0.000 description 8
- 238000006731 degradation reaction Methods 0.000 description 8
- 239000013078 crystal Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000012254 powdered material Substances 0.000 description 6
- 238000007711 solidification Methods 0.000 description 6
- 230000008023 solidification Effects 0.000 description 6
- 229960002237 metoprolol Drugs 0.000 description 5
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 5
- 239000012768 molten material Substances 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000010419 fine particle Substances 0.000 description 4
- 239000012798 spherical particle Substances 0.000 description 4
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 4
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 229940081974 saccharin Drugs 0.000 description 2
- 235000019204 saccharin Nutrition 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- CRDNMYFJWFXOCH-BUHFOSPRSA-N Couroupitine B Natural products N\1C2=CC=CC=C2C(=O)C/1=C1/C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-BUHFOSPRSA-N 0.000 description 1
- 229920002292 Nylon 6 Polymers 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 230000035508 accumulation Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229960004308 acetylcysteine Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- PAZJSJFMUHDSTF-UHFFFAOYSA-N alprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1CC=C PAZJSJFMUHDSTF-UHFFFAOYSA-N 0.000 description 1
- 229960002213 alprenolol Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000007771 core particle Substances 0.000 description 1
- 239000010431 corundum Substances 0.000 description 1
- 229910052593 corundum Inorganic materials 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000009477 fluid bed granulation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000011361 granulated particle Substances 0.000 description 1
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 1
- CRDNMYFJWFXOCH-UHFFFAOYSA-N indirubin Chemical compound N1C2=CC=CC=C2C(=O)C1=C1C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000007909 melt granulation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical class C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000005029 sieve analysis Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229960001947 tripalmitin Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
- B29C67/02—Moulding by agglomerating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/14—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating dishes or pans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/28—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using special binding agents
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Disintegrating Or Milling (AREA)
- Medicinal Preparation (AREA)
- Glanulating (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Seasonings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Photoreceptors In Electrophotography (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/838,828 US5019302A (en) | 1986-03-12 | 1986-03-12 | Method for granulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD265336A5 true DD265336A5 (de) | 1989-03-01 |
Family
ID=25278149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD87300665A DD265336A5 (de) | 1986-03-12 | 1987-03-11 | Verfahren und vorrichtung zum granulieren und granuliertes produkt |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5019302A (cs) |
| EP (1) | EP0237345B1 (cs) |
| JP (1) | JPH01501768A (cs) |
| KR (1) | KR880701175A (cs) |
| CN (1) | CN1013479B (cs) |
| AT (1) | ATE64547T1 (cs) |
| AU (1) | AU591268B2 (cs) |
| BR (1) | BR8707635A (cs) |
| CA (1) | CA1321692C (cs) |
| CS (1) | CS150887A3 (cs) |
| DD (1) | DD265336A5 (cs) |
| DE (1) | DE3770843D1 (cs) |
| EG (1) | EG17922A (cs) |
| ES (1) | ES2023892B3 (cs) |
| FI (1) | FI884162A0 (cs) |
| GR (1) | GR3002725T3 (cs) |
| HU (1) | HUT48522A (cs) |
| IL (1) | IL81760A (cs) |
| IS (1) | IS1499B (cs) |
| NZ (1) | NZ219532A (cs) |
| PL (1) | PL264591A1 (cs) |
| PT (1) | PT84438B (cs) |
| WO (1) | WO1987005561A1 (cs) |
| ZA (1) | ZA871163B (cs) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5100592A (en) * | 1986-03-12 | 1992-03-31 | Washington University Technology Associated, Inc. | Method and apparatus for granulation and granulated product |
| ATE75394T1 (de) * | 1986-11-14 | 1992-05-15 | Ciba Geigy Ag | Orales osmotisches system fuer metoprolol mit verbesserten formulierungseigenschaften. |
| US5137669A (en) * | 1988-03-02 | 1992-08-11 | Endocon, Inc. | Manufacture of partially fused peptide pellet |
| JP3191948B2 (ja) * | 1990-04-12 | 2001-07-23 | 塩野義製薬株式会社 | 被覆製剤およびその製造法 |
| US5290569A (en) * | 1990-04-12 | 1994-03-01 | Shionogi & Co., Ltd. | Coated composition and its preparation process |
| US5342557A (en) * | 1990-11-27 | 1994-08-30 | United States Surgical Corporation | Process for preparing polymer particles |
| US5143662A (en) * | 1991-02-12 | 1992-09-01 | United States Surgical Corporation | Process for preparing particles of bioabsorbable polymer |
| US5429825A (en) * | 1992-06-26 | 1995-07-04 | Mcneil-Ppc, Inc. | Rotomelt granulation |
| US5628945A (en) * | 1992-08-03 | 1997-05-13 | Riman; Richard E. | Multicomponent powder mixing process and compositions produced thereby |
| US5447565A (en) * | 1993-12-10 | 1995-09-05 | Wm. Wrigley Jr. Company | Apparatus and method for coating particles |
| US5508276A (en) | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
| US5700497A (en) * | 1995-06-12 | 1997-12-23 | Kason Corporation | Vibratory agglomerator |
| WO1998022474A1 (fr) * | 1996-11-20 | 1998-05-28 | Otkrytoe Aktsionernoe Obschestvo 'aviabor' Dzerzhinsky Opytny Zavod Aviatsionnykh Materialov | Procede de fabrication de granules d'une substance thermolabile et installation requise |
| EP1314764B1 (en) * | 1997-05-15 | 2005-09-07 | Kansai Paint Co., Ltd. | Process for preparing a granulated powder coating composition |
| DE19933289A1 (de) * | 1999-07-15 | 2001-01-18 | Basf Ag | Verfahren zur Herstellung eines Granulats aus einer Schmelze |
| US6273260B1 (en) | 2000-03-08 | 2001-08-14 | Eli Lilly And Company | Pharmaceutical packaging system |
| US6631808B2 (en) | 2001-08-07 | 2003-10-14 | Particle And Coating Technologies, Inc. | Air classifier system for the separation of particles |
| US6691765B2 (en) | 2001-08-07 | 2004-02-17 | Noram Technology, Ltd. | Products for the manufacture of molds and cores used in metal casting and a method for their manufacture and recycle from crushed rock |
| US6932286B2 (en) * | 2001-11-07 | 2005-08-23 | Fred P. Smith | Combination drop and broadcast spreader |
| EP1589957A1 (en) * | 2003-02-05 | 2005-11-02 | IPCA Laboratories Limited | Pharmaceutical compositions and process of production thereof |
| US20040265378A1 (en) * | 2003-06-25 | 2004-12-30 | Yingxu Peng | Method and compositions for producing granules containing high concentrations of biologically active substances |
| EP1491253A1 (en) * | 2003-06-26 | 2004-12-29 | Urea Casale S.A. | Fluid bed granulation process and apparatus |
| US7314640B2 (en) * | 2003-07-11 | 2008-01-01 | Mongkol Sriwongjanya | Formulation and process for drug loaded cores |
| CA2547597A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate compositions with improved stability |
| WO2005053639A2 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Controlled release multiparticulates formed with dissolution enhancers |
| US6984403B2 (en) * | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
| ATE399536T1 (de) * | 2003-12-04 | 2008-07-15 | Pfizer Prod Inc | Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten |
| CN1889931A (zh) * | 2003-12-04 | 2007-01-03 | 辉瑞产品公司 | 利用挤压器制备优选含泊洛沙姆和甘油酯的多重粒子阿奇霉素组合物的喷雾－冻凝方法 |
| JP2007513147A (ja) * | 2003-12-04 | 2007-05-24 | ファイザー・プロダクツ・インク | 押し出し機を使用して、好ましくはポロキサマーとグリセリドを含有する多粒子結晶性医薬組成物を製造するための噴霧凝結方法 |
| WO2005053652A1 (en) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride |
| ATE534876T1 (de) * | 2004-09-21 | 2011-12-15 | Iglesias Vives Joan | Verfahren und maschine zum sintern und/oder trocknen von pulvermaterialien unter verwendung von infrarotstrahlung |
| US20070053983A1 (en) * | 2005-09-06 | 2007-03-08 | Girish Jain | Extended release compositions of metoprolol succinate |
| US7261529B2 (en) * | 2005-09-07 | 2007-08-28 | Southwest Research Institute | Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents |
| US7758778B2 (en) * | 2005-09-07 | 2010-07-20 | Southwest Research Institute | Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents |
| US9693967B2 (en) * | 2005-09-07 | 2017-07-04 | Southwest Research Institute | Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates |
| US8563032B2 (en) | 2005-12-05 | 2013-10-22 | Roxane Laboratories, Inc. | Formulation and manufacturing process for calcium acetate capsules |
| US20110217553A1 (en) * | 2007-12-20 | 2011-09-08 | Warner Isiah M | Frozen Ionic Liquid Microparticles and Nanoparticles, and Methods for their Synthesis and Use |
| JP2010099586A (ja) * | 2008-10-23 | 2010-05-06 | National Institute For Materials Science | 固形粒子の製造装置及び製造方法 |
| CN102413915B (zh) * | 2009-03-16 | 2014-06-04 | Gabae技术有限责任公司 | 使用旋转毛细管来制造颗粒的装置、系统和方法 |
| US8951541B2 (en) * | 2010-10-04 | 2015-02-10 | 3M Innovative Properties Company | Method of modifying dissolution rate of particles by addition of hydrophobic nanoparticles |
| CN104062210B (zh) * | 2013-12-13 | 2018-04-27 | 郑州轻工业学院 | 颗粒采集及检测系统 |
| KR102193599B1 (ko) | 2014-09-17 | 2020-12-21 | 스티어라이프 인디아 프라이빗 리미티드 | 발포성 조성물 및 이의 제조방법 |
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| CN105128165A (zh) * | 2015-07-13 | 2015-12-09 | 北京化工大学 | 一种离心法制备聚合物超细颗粒的装置 |
| CN105342857A (zh) * | 2015-12-07 | 2016-02-24 | 江苏知原药业有限公司 | 一种中药滴丸制备设备 |
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| CN106994316A (zh) * | 2017-05-31 | 2017-08-01 | 安硕文教用品（上海）股份有限公司 | 一种铅笔料颗粒机 |
| CN107362047B (zh) * | 2017-08-25 | 2023-02-17 | 七次方家用电器（上海）有限公司 | 分料机构 |
| CN108889238A (zh) * | 2018-06-29 | 2018-11-27 | 东北大学 | 液态氯化镁粒化装置及余热回收系统与方法 |
| CN112371054A (zh) * | 2020-10-22 | 2021-02-19 | 武汉木兰山水生态农业发展有限公司 | 一种微生物肥料离心造粒方法 |
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-
1986
- 1986-03-12 US US06/838,828 patent/US5019302A/en not_active Expired - Lifetime
-
1987
- 1987-02-12 CA CA000529571A patent/CA1321692C/en not_active Expired - Fee Related
- 1987-02-18 ZA ZA871163A patent/ZA871163B/xx unknown
- 1987-02-26 IS IS3199A patent/IS1499B/is unknown
- 1987-03-03 IL IL81760A patent/IL81760A/xx unknown
- 1987-03-04 JP JP62501926A patent/JPH01501768A/ja active Pending
- 1987-03-04 AU AU71626/87A patent/AU591268B2/en not_active Ceased
- 1987-03-04 HU HU871809A patent/HUT48522A/hu unknown
- 1987-03-04 WO PCT/US1987/000434 patent/WO1987005561A1/en not_active Ceased
- 1987-03-04 BR BR8707635A patent/BR8707635A/pt not_active Application Discontinuation
- 1987-03-05 EG EG125/87A patent/EG17922A/xx active
- 1987-03-06 CS CS871508A patent/CS150887A3/cs unknown
- 1987-03-06 NZ NZ219532A patent/NZ219532A/en unknown
- 1987-03-10 PT PT84438A patent/PT84438B/pt not_active IP Right Cessation
- 1987-03-11 DE DE8787302115T patent/DE3770843D1/de not_active Expired - Lifetime
- 1987-03-11 AT AT87302115T patent/ATE64547T1/de not_active IP Right Cessation
- 1987-03-11 EP EP87302115A patent/EP0237345B1/en not_active Expired - Lifetime
- 1987-03-11 DD DD87300665A patent/DD265336A5/de not_active IP Right Cessation
- 1987-03-11 ES ES87302115T patent/ES2023892B3/es not_active Expired - Lifetime
- 1987-03-12 PL PL1987264591A patent/PL264591A1/xx unknown
- 1987-03-12 CN CN87101837A patent/CN1013479B/zh not_active Expired
- 1987-11-12 KR KR1019870701034A patent/KR880701175A/ko not_active Ceased
-
1988
- 1988-09-09 FI FI884162A patent/FI884162A0/fi not_active IP Right Cessation
-
1991
- 1991-09-16 GR GR91401340T patent/GR3002725T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7162687A (en) | 1987-10-09 |
| HUT48522A (en) | 1989-06-28 |
| CS150887A3 (en) | 1992-11-18 |
| GR3002725T3 (en) | 1993-01-25 |
| IS1499B (is) | 1992-07-30 |
| EP0237345A3 (en) | 1988-11-02 |
| EP0237345B1 (en) | 1991-06-19 |
| PL264591A1 (en) | 1988-04-28 |
| PT84438B (pt) | 1989-10-04 |
| WO1987005561A1 (en) | 1987-09-24 |
| FI884162A7 (fi) | 1988-09-09 |
| EG17922A (en) | 1991-06-30 |
| AU591268B2 (en) | 1989-11-30 |
| CN1013479B (zh) | 1991-08-14 |
| ATE64547T1 (de) | 1991-07-15 |
| BR8707635A (pt) | 1989-03-14 |
| ZA871163B (en) | 1987-09-30 |
| CA1321692C (en) | 1993-08-31 |
| PT84438A (en) | 1987-04-01 |
| JPH01501768A (ja) | 1989-06-22 |
| FI884162A0 (fi) | 1988-09-09 |
| DE3770843D1 (de) | 1991-07-25 |
| IL81760A (en) | 1990-04-29 |
| ES2023892B3 (es) | 1992-02-16 |
| NZ219532A (en) | 1990-01-29 |
| EP0237345A2 (en) | 1987-09-16 |
| IS3199A7 (is) | 1987-09-13 |
| US5019302A (en) | 1991-05-28 |
| KR880701175A (ko) | 1988-07-26 |
| CN87101837A (zh) | 1987-12-02 |
| IL81760A0 (en) | 1987-10-20 |
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