DD283820A5 - Verfahren zur herstellung von 1,2-dithiol-3-thion-s-oxid-verbindungen - Google Patents

Verfahren zur herstellung von 1,2-dithiol-3-thion-s-oxid-verbindungen Download PDF

Info

Publication number: DD283820A5
Authority: DD; German Democratic Republic
Prior art keywords: dithiol; thione; compounds; formula; carbon atoms
Prior art date: 1988-05-27

Application number

DD89328800A

Other languages

German (de)

English (en)

Inventor

Dominique Biard

Marie-Odile Christen

Patrick Dansette

Daniel Jasserand

Daniel Mansuy

Amor Sassi

Original Assignee

��`��@��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-27

Filing date

1989-05-22

Publication date

1990-10-24

1989-05-22 Application filed by ��`��@��@��k�� filed Critical ��`��@��@��k��

1990-10-24 Publication of DD283820A5 publication Critical patent/DD283820A5/de

Links

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238000004519 manufacturing process Methods 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 27
238000000034 method Methods 0.000 claims abstract description 17
238000002360 preparation method Methods 0.000 claims abstract description 12
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229940079593 drug Drugs 0.000 claims abstract description 4
125000004432 carbon atom Chemical group C* 0.000 claims description 13
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230000002443 hepatoprotective effect Effects 0.000 claims description 10
125000003545 alkoxy group Chemical group 0.000 claims description 9
229910052736 halogen Inorganic materials 0.000 claims description 8
125000000217 alkyl group Chemical group 0.000 claims description 7
229910052739 hydrogen Inorganic materials 0.000 claims description 7
239000001257 hydrogen Substances 0.000 claims description 7
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
125000005530 alkylenedioxy group Chemical group 0.000 claims description 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
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125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
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239000002243 precursor Substances 0.000 claims 1
239000000126 substance Substances 0.000 abstract description 15
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PORXOKAPCYTNPQ-UHFFFAOYSA-N 5-(4-chlorophenyl)dithiole-3-thione Chemical compound C1=CC(Cl)=CC=C1C1=CC(=S)SS1 PORXOKAPCYTNPQ-UHFFFAOYSA-N 0.000 description 1
XXDYQIINMXOSSO-UHFFFAOYSA-N 5-(4-hydroxyphenyl)dithiol-3-one Chemical compound C1=CC(O)=CC=C1C1=CC(=O)SS1 XXDYQIINMXOSSO-UHFFFAOYSA-N 0.000 description 1
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101710098398 Probable alanine aminotransferase, mitochondrial Proteins 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

DD89328800A 1988-05-27 1989-05-22 Verfahren zur herstellung von 1,2-dithiol-3-thion-s-oxid-verbindungen DD283820A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP88401304A EP0343303A1 (fr)	1988-05-27	1988-05-27	Médicaments contenant des composés 1,2-dithiol-3-thione-S-oxyde

Publications (1)

Publication Number	Publication Date
DD283820A5 true DD283820A5 (de)	1990-10-24

Family

ID=8200390

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD89328800A DD283820A5 (de)	1988-05-27	1989-05-22	Verfahren zur herstellung von 1,2-dithiol-3-thion-s-oxid-verbindungen

Country Status (22)

Country	Link
US (1)	US5096920A (fr)
EP (2)	EP0343303A1 (fr)
JP (1)	JP2718429B2 (fr)
KR (1)	KR970011289B1 (fr)
CN (2)	CN1027893C (fr)
AR (1)	AR247207A1 (fr)
AU (1)	AU624141B2 (fr)
CA (1)	CA1332609C (fr)
DD (1)	DD283820A5 (fr)
DE (1)	DE58905106D1 (fr)
DK (1)	DK175286B1 (fr)
DZ (1)	DZ1340A1 (fr)
ES (1)	ES2058386T3 (fr)
FI (1)	FI88503C (fr)
GR (1)	GR3009107T3 (fr)
HU (1)	HU203745B (fr)
IE (1)	IE63291B1 (fr)
IL (1)	IL90407A0 (fr)
NO (1)	NO172579C (fr)
NZ (1)	NZ229274A (fr)
PT (1)	PT90521B (fr)
ZA (1)	ZA893037B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6437092B1 (en) *	1998-11-06	2002-08-20	Conjuchem, Inc.	Conjugates of opioids and endogenous carriers
KR100484526B1 (ko) *	2002-11-13	2005-04-20	씨제이 주식회사	티온 유도체, 그 제조방법 및 약제학적 조성물
CN101463030B (zh) *	2009-01-09	2012-03-21	福建深纳生物工程有限公司	茴三硫的制备方法
CN103012394B (zh) *	2012-11-19	2015-03-25	苏州大学	一种罗丹宁衍生物及其制备方法
CN102993166B (zh) *	2012-12-13	2015-05-13	苏州大学	一种3h-1,2-二硫环戊烯-3-硫酮类化合物的制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE874447C (de) *	1944-08-22	1953-04-23	Bruno Dr Boettcher	Verfahren zur Herstellung von 5-Thion-1, 2-dithiolen
US2556963A (en) *	1946-07-15	1951-06-12	Gaudin Olivier	Benzenes containing sulfur in their allylic or propenylic side chains and process of preparing them
US2662899A (en) *	1950-07-29	1953-12-15	Stauffer Chemical Co	Chlorinated cyclic organic trithiocarbonate and process for preparing same
US2688620A (en) *	1951-05-04	1954-09-07	Gaudin Olivier	Trisulfureted heterocyclic compounds
US2816116A (en) *	1954-06-01	1957-12-10	Standard Oil Co	2-para-t-butyl phenyl trithione
US3225062A (en) *	1963-02-11	1965-12-21	American Cyanamid Co	Process for 1,2-dithiole-3-thiones
US3214442A (en) *	1963-06-26	1965-10-26	American Cyanamid Co	4, 5-dicyano-1, 3-dithiole-2-thione oxide and its preparation
US3847943A (en) *	1972-09-08	1974-11-12	P Warner	Preparing anethole trithione using sulfolane solvent

1988
- 1988-05-27 EP EP88401304A patent/EP0343303A1/fr not_active Withdrawn
1989
- 1989-04-21 KR KR1019890005296A patent/KR970011289B1/ko not_active Expired - Fee Related
- 1989-04-25 ZA ZA893037A patent/ZA893037B/xx unknown
- 1989-04-28 AR AR89313802A patent/AR247207A1/es active
- 1989-05-10 PT PT90521A patent/PT90521B/pt not_active IP Right Cessation
- 1989-05-21 DZ DZ890078A patent/DZ1340A1/fr active
- 1989-05-22 HU HU892514A patent/HU203745B/hu unknown
- 1989-05-22 DD DD89328800A patent/DD283820A5/de unknown
- 1989-05-23 ES ES89109207T patent/ES2058386T3/es not_active Expired - Lifetime
- 1989-05-23 DE DE8989109207T patent/DE58905106D1/de not_active Expired - Lifetime
- 1989-05-23 EP EP89109207A patent/EP0343573B1/fr not_active Expired - Lifetime
- 1989-05-25 IL IL90407A patent/IL90407A0/xx not_active IP Right Cessation
- 1989-05-25 NZ NZ229274A patent/NZ229274A/xx unknown
- 1989-05-26 CN CN89103718A patent/CN1027893C/zh not_active Expired - Fee Related
- 1989-05-26 US US07/357,271 patent/US5096920A/en not_active Expired - Lifetime
- 1989-05-26 JP JP1131700A patent/JP2718429B2/ja not_active Expired - Lifetime
- 1989-05-26 DK DK198902566A patent/DK175286B1/da not_active IP Right Cessation
- 1989-05-26 FI FI892571A patent/FI88503C/fi not_active IP Right Cessation
- 1989-05-26 NO NO892147A patent/NO172579C/no not_active IP Right Cessation
- 1989-05-26 AU AU35216/89A patent/AU624141B2/en not_active Ceased
- 1989-05-29 CA CA000601030A patent/CA1332609C/fr not_active Expired - Fee Related
- 1989-06-12 IE IE177789A patent/IE63291B1/en not_active IP Right Cessation
1993
- 1993-09-21 GR GR930400136T patent/GR3009107T3/el unknown
1994
- 1994-02-09 CN CN94101573A patent/CN1047171C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1047171C (zh)	1999-12-08
FI892571A0 (fi)	1989-05-26
NO892147D0 (no)	1989-05-26
FI88503B (fi)	1993-02-15
CA1332609C (fr)	1994-10-18
NO172579B (no)	1993-05-03
HU203745B (en)	1991-09-30
JPH0219376A (ja)	1990-01-23
CN1039246A (zh)	1990-01-31
KR890017241A (ko)	1989-12-15
HUT49870A (en)	1989-11-28
DK175286B1 (da)	2004-08-09
GR3009107T3 (fr)	1993-12-30
NO172579C (no)	1993-08-11
AU3521689A (en)	1989-11-30
EP0343573A1 (fr)	1989-11-29
FI892571L (fi)	1989-11-28
DK256689A (da)	1989-11-28
PT90521B (pt)	1994-10-31
ZA893037B (en)	1989-12-27
AU624141B2 (en)	1992-06-04
US5096920A (en)	1992-03-17
CN1101348A (zh)	1995-04-12
ES2058386T3 (es)	1994-11-01
PT90521A (pt)	1989-11-30
KR970011289B1 (ko)	1997-07-09
IE891777L (en)	1989-11-27
DE58905106D1 (de)	1993-09-09
CN1027893C (zh)	1995-03-15
FI88503C (fi)	1993-05-25
IE63291B1 (en)	1995-04-05
NO892147L (no)	1989-11-28
DK256689D0 (da)	1989-05-26
EP0343303A1 (fr)	1989-11-29
NZ229274A (en)	1990-10-26
DZ1340A1 (fr)	2004-09-13
AR247207A1 (es)	1994-11-30
IL90407A0 (en)	1990-01-18
EP0343573B1 (fr)	1993-08-04
JP2718429B2 (ja)	1998-02-25

Legal Events

Date	Code	Title	Description
1994-04-14	RPV	Change in the person, the name or the address of the representative (searches according to art. 11 and 12 extension act)
1997-08-14	RPI	Change in the person, name or address of the patentee (searches according to art. 11 and 12 extension act)
2004-04-28	ASS	Change of applicant or owner	Owner name: SOLVAY PHARMACEUTICALS GMBH, HANNOVER Effective date: 19970619
2004-04-28	IF04	In force in the year 2004	Expiry date: 20090523

Publication	Publication Date	Title
DE2928485A1 (de)	1981-01-29	Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen
DE2516554A1 (de)	1975-10-30	Thienyl- und thiaethylverbindungen
DE2705582B2 (fr)	1980-08-21
DE2233458A1 (de)	1973-02-08	Neue chinolinderivate
EP0046961A1 (fr)	1982-03-10	Acides époxy-cycloalcoylalcanoiques, procédé pour les préparer, leur utilisation et médicaments les contenant
EP0343573B1 (fr)	1993-08-04	Médicaments contenant des composés 1,2-dithiol-3-thione-S-oxyde
DE2523103A1 (de)	1976-12-09	Neue propargyl-2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
EP0075140B1 (fr)	1984-12-19	Acides thiazolyl-oxamiques tricycliques et dérivés, procédé pour leur fabrication, et moyens thérapeutiques les contenant
EP0101898A1 (fr)	1984-03-07	4H-1,4-benzothiazines condensées, procédé pour leur préparation et leur application comme médicaments
EP0061056A1 (fr)	1982-09-29	5,6-Diméthylpyrrolo (2,3-b) pyridines, procédé pour leur préparation et leur utilisation comme médicament
DE2749584A1 (de)	1978-05-18	Ueberbrueckte geminale diphenylpiperidine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
EP0313935B1 (fr)	1994-07-27	Enoléthers de 6-chloro-4-hydroxy-2-méthyl-N-(2-pyridyl)-2H-thiéno(2,3-e)-1,2-thiazin-3-carboxamides-1,1-dioxyde, un procédé pour leur préparation et leur utilisation
EP0301428A2 (fr)	1989-02-01	Dérivés de benzyldiaminopyrimidine et leur utilisation comme médicaments
DD283817A5 (de)	1990-10-24	Verfahren zur herstellung heterocyclischer nitromethanderivate
EP0030343B1 (fr)	1983-08-31	Amino-2 dihydro-3,4-pyridines substituées, procédé pour leur préparation et utilisation comme médicaments
EP0241834A2 (fr)	1987-10-21	Utilisation de 3-carbamoyl-4-hydroxy-coumarines pour combattre les helminthes parasitaires, les 3-carbamoyl-4-hydroxy-coumarines et leur préparation
EP0149818A2 (fr)	1985-07-31	Dérivés de 1,4-naphtoquinone, procédé pour leur préparation et leur utilisation comme médicaments
DE4134893A1 (de)	1993-04-29	Thiadiazinone
EP0147778A2 (fr)	1985-07-10	Dérivés de 1,4-naphthoquinone anti-inflammatoires
EP0213295B1 (fr)	1991-04-10	Dérivés de thiéno-1,2-thiazole, leur procédé de préparation et compositions pharmaceutiques les contenant
DE3025656C2 (fr)	1989-06-22
DE2415064A1 (de)	1974-10-10	N-arylsulfonylharnstoffderivate, sie enthaltende arzneimittel und ihre herstellung
EP0095641A1 (fr)	1983-12-07	Dérivés de la quinazolinone, leur procédé de préparation et leur utilisation dans des médicaments
EP0253182A1 (fr)	1988-01-20	Utilisation de thiadiazinones pour combattre les endoparasites
EP0049538A2 (fr)	1982-04-14	Utilisation des dérivés de thiourée comme médicaments dans le traitement des dérèglements du métabolisme des lipides