DD294935A5 - Verfahren zur herstellung von halogensubstituierten diphenylsulfiden und einer sie enthaltenden pharmazeutischen zubereitung - Google Patents

Verfahren zur herstellung von halogensubstituierten diphenylsulfiden und einer sie enthaltenden pharmazeutischen zubereitung Download PDF

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Publication number
DD294935A5
DD294935A5 DD90341317A DD34131790A DD294935A5 DD 294935 A5 DD294935 A5 DD 294935A5 DD 90341317 A DD90341317 A DD 90341317A DD 34131790 A DD34131790 A DD 34131790A DD 294935 A5 DD294935 A5 DD 294935A5
Authority
DD
German Democratic Republic
Prior art keywords
pharmaceutically acceptable
compound
general formula
thio
methyl
Prior art date
Application number
DD90341317A
Other languages
German (de)
English (en)
Inventor
Nariman B Mehta
Lawrence E Brieaddy
Hollingsworth Claudia E Baxter
Barrett R Cooper
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by ��������@��������@����������@���k�� filed Critical ��������@��������@����������@���k��
Publication of DD294935A5 publication Critical patent/DD294935A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/17—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DD90341317A 1989-06-06 1990-06-05 Verfahren zur herstellung von halogensubstituierten diphenylsulfiden und einer sie enthaltenden pharmazeutischen zubereitung DD294935A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898912971A GB8912971D0 (en) 1989-06-06 1989-06-06 Halogen substituted diphenylsulfides

Publications (1)

Publication Number Publication Date
DD294935A5 true DD294935A5 (de) 1991-10-17

Family

ID=10657952

Family Applications (1)

Application Number Title Priority Date Filing Date
DD90341317A DD294935A5 (de) 1989-06-06 1990-06-05 Verfahren zur herstellung von halogensubstituierten diphenylsulfiden und einer sie enthaltenden pharmazeutischen zubereitung

Country Status (18)

Country Link
US (2) US5095039A (ja)
EP (1) EP0402097A1 (ja)
JP (1) JPH0324052A (ja)
KR (1) KR910000630A (ja)
AU (1) AU636892B2 (ja)
CA (1) CA2018307A1 (ja)
DD (1) DD294935A5 (ja)
FI (1) FI902801A7 (ja)
GB (1) GB8912971D0 (ja)
HU (1) HUT57717A (ja)
IL (1) IL94620A0 (ja)
MX (1) MX9203419A (ja)
NO (1) NO902474L (ja)
NZ (1) NZ233929A (ja)
PH (1) PH27095A (ja)
PL (1) PL285487A1 (ja)
PT (1) PT94273A (ja)
ZA (1) ZA904313B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8912971D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Halogen substituted diphenylsulfides
GB9126311D0 (en) * 1991-12-11 1992-02-12 Wellcome Found Substituted diphenylsulfides
CZ293595A3 (cs) * 1995-11-09 1999-12-15 Farmak A. S. Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích
JP2002543173A (ja) * 1999-04-30 2002-12-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア セロトニン輸送体のためのｓｐｅｃｔ画像化剤
US6921840B1 (en) 1999-04-30 2005-07-26 The Trustees Of The University Of Pennsylvania SPECT imaging agents for serotonin transporters
US6448293B1 (en) 2000-03-31 2002-09-10 Pfizer Inc. Diphenyl ether compounds useful in therapy
US6610747B2 (en) 2000-08-31 2003-08-26 Pfizer Inc. Phenoxybenzylamine derivatives as SSRIs
US6630504B2 (en) 2000-08-31 2003-10-07 Pfizer Inc. Phenoxyphenylheterocyclyl derivatives as SSRIs
AU2003223278A1 (en) 2002-03-14 2003-09-29 Hank F. Kung Fluorinated phenyl thiophenyl derivatives and their use for imaging serotonin transporters
UA81300C2 (en) * 2003-04-04 2007-12-25 Lundbeck & Co As H Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture
CA2521258C (en) * 2003-04-04 2009-12-01 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
TWI347183B (en) 2003-12-23 2011-08-21 Lundbeck & Co As H 2-(1h-indolylsulfanyl)-benzyl amine derivatives
ATE396970T1 (de) 2003-12-23 2008-06-15 Lundbeck & Co As H 2-(1h-indolylsulfanyl)-benzylaminderivate als ssri
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
US7629473B2 (en) * 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) * 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254125A (en) * 1963-11-29 1966-05-31 Universal Oil Prod Co Preparation of aminodiphenyl sulfides
US4194009A (en) * 1974-01-10 1980-03-18 Eli Lilly And Company Aryloxyphenylpropylamines for obtaining a psychotropic effect
DE2516382A1 (de) * 1974-04-18 1975-11-06 Ciba Geigy Ag Phenyl-aralkyl-aether, -thioaether und -amine
US4055665A (en) * 1974-11-25 1977-10-25 Merck & Co., Inc. Treating arrythmia with phenylthioaralkylamines
US4056632A (en) * 1975-07-21 1977-11-01 Burroughs Wellcome Co. 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use
US3997540A (en) * 1975-07-21 1976-12-14 Burroughs Wellcome Co. O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates
CS261295B1 (cs) * 1987-07-17 1989-01-12 Karel Sindelar Amidiny a amidoximy difenylsulfidové řady á jejich soli
EP0396827A1 (en) * 1989-05-09 1990-11-14 SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu 2-Phenylthiobenzylamine dervivatives and acid addition salts thereof
GB8912971D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Halogen substituted diphenylsulfides

Also Published As

Publication number Publication date
AU636892B2 (en) 1993-05-13
NZ233929A (en) 1992-05-26
HU903486D0 (en) 1990-10-28
US5104897A (en) 1992-04-14
ZA904313B (en) 1992-02-26
IL94620A0 (en) 1991-04-15
MX9203419A (es) 1992-07-01
GB8912971D0 (en) 1989-07-26
US5095039A (en) 1992-03-10
PL285487A1 (en) 1991-01-28
KR910000630A (ko) 1991-01-29
NO902474D0 (no) 1990-06-05
NO902474L (no) 1990-12-07
JPH0324052A (ja) 1991-02-01
AU5684190A (en) 1990-12-13
FI902801A0 (fi) 1990-06-05
EP0402097A1 (en) 1990-12-12
HUT57717A (en) 1991-12-30
FI902801A7 (fi) 1990-12-07
PH27095A (en) 1993-02-26
PT94273A (pt) 1991-02-08
CA2018307A1 (en) 1990-12-06

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