DD295344A5 - Benzanilide - Google Patents
Benzanilide Download PDFInfo
- Publication number
- DD295344A5 DD295344A5 DD90344265A DD34426590A DD295344A5 DD 295344 A5 DD295344 A5 DD 295344A5 DD 90344265 A DD90344265 A DD 90344265A DD 34426590 A DD34426590 A DD 34426590A DD 295344 A5 DD295344 A5 DD 295344A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- group
- benzamide
- methylthio
- methoxy
- carbon atoms
- Prior art date
Links
- ZVSKZLHKADLHSD-UHFFFAOYSA-N benzanilide Chemical class C=1C=CC=CC=1C(=O)NC1=CC=CC=C1 ZVSKZLHKADLHSD-UHFFFAOYSA-N 0.000 title claims abstract description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 49
- 150000001875 compounds Chemical class 0.000 claims abstract description 35
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 22
- 239000001257 hydrogen Substances 0.000 claims abstract description 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 8
- 125000005843 halogen group Chemical group 0.000 claims abstract description 8
- 125000002252 acyl group Chemical group 0.000 claims abstract description 7
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 7
- 239000001301 oxygen Substances 0.000 claims abstract description 7
- 125000005236 alkanoylamino group Chemical group 0.000 claims abstract description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 5
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims abstract description 5
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 4
- -1 2-methoxyethylaminocarbonyl Chemical group 0.000 claims description 79
- 229910052757 nitrogen Inorganic materials 0.000 claims description 33
- 229910052717 sulfur Inorganic materials 0.000 claims description 31
- 125000004432 carbon atom Chemical group C* 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 21
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 9
- 239000000460 chlorine Substances 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims description 4
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 4
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 150000008064 anhydrides Chemical class 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000011737 fluorine Substances 0.000 claims description 2
- 229910052731 fluorine Inorganic materials 0.000 claims description 2
- 125000002541 furyl group Chemical group 0.000 claims description 2
- 125000001786 isothiazolyl group Chemical group 0.000 claims description 2
- 125000002757 morpholinyl group Chemical group 0.000 claims description 2
- 125000003386 piperidinyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
- 125000004434 sulfur atom Chemical group 0.000 claims description 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims description 2
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 1
- 230000000879 anti-atherosclerotic effect Effects 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 229910052736 halogen Inorganic materials 0.000 abstract description 2
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 144
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 114
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 69
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 54
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 51
- 239000000203 mixture Substances 0.000 description 40
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 27
- 238000000921 elemental analysis Methods 0.000 description 25
- 239000000243 solution Substances 0.000 description 25
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 239000003208 petroleum Substances 0.000 description 14
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
- YAMRKMLTCHKZJD-UHFFFAOYSA-N 3-amino-n-(2-methoxyethyl)-4-methylsulfanylbenzamide Chemical compound COCCNC(=O)C1=CC=C(SC)C(N)=C1 YAMRKMLTCHKZJD-UHFFFAOYSA-N 0.000 description 9
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 8
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 238000002425 crystallisation Methods 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 8
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 7
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 239000013078 crystal Substances 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 230000008025 crystallization Effects 0.000 description 6
- 238000001665 trituration Methods 0.000 description 6
- 238000010992 reflux Methods 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- NZNICZRIRMGOFG-UHFFFAOYSA-N 4-decoxybenzoic acid Chemical compound CCCCCCCCCCOC1=CC=C(C(O)=O)C=C1 NZNICZRIRMGOFG-UHFFFAOYSA-N 0.000 description 4
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 230000006978 adaptation Effects 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 239000003480 eluent Substances 0.000 description 4
- 239000003701 inert diluent Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 4
- 235000019341 magnesium sulphate Nutrition 0.000 description 4
- UQLQARPYHKDGAI-UHFFFAOYSA-N n-(2-methoxyethyl)-4-methylsulfanyl-3-nitrobenzamide Chemical compound COCCNC(=O)C1=CC=C(SC)C([N+]([O-])=O)=C1 UQLQARPYHKDGAI-UHFFFAOYSA-N 0.000 description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000001953 recrystallisation Methods 0.000 description 4
- 239000008247 solid mixture Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- JIMREUKKAQBFMO-UHFFFAOYSA-N 3-amino-4-methoxy-n-(2-methylsulfanylethyl)benzamide Chemical group COC1=CC=C(C(=O)NCCSC)C=C1N JIMREUKKAQBFMO-UHFFFAOYSA-N 0.000 description 3
- UFJFLHXOHCJBMH-UHFFFAOYSA-N 3-amino-4-methylsulfanyl-n-(2-methylsulfanylethyl)benzamide Chemical group CSCCNC(=O)C1=CC=C(SC)C(N)=C1 UFJFLHXOHCJBMH-UHFFFAOYSA-N 0.000 description 3
- ALNGFXNHCQVYOE-UHFFFAOYSA-N 4-decylsulfanylbenzoic acid Chemical compound CCCCCCCCCCSC1=CC=C(C(O)=O)C=C1 ALNGFXNHCQVYOE-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229940072049 amyl acetate Drugs 0.000 description 3
- PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 238000003818 flash chromatography Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- MLFKUEQFNLAOQT-UHFFFAOYSA-N methyl 4-methylsulfanyl-3-nitrobenzoate Chemical compound COC(=O)C1=CC=C(SC)C([N+]([O-])=O)=C1 MLFKUEQFNLAOQT-UHFFFAOYSA-N 0.000 description 3
- HCOITUYQNKEZQH-UHFFFAOYSA-N 1-bromo-4-decylsulfanylbenzene Chemical compound CCCCCCCCCCSC1=CC=C(Br)C=C1 HCOITUYQNKEZQH-UHFFFAOYSA-N 0.000 description 2
- ASUDFOJKTJLAIK-UHFFFAOYSA-N 2-methoxyethanamine Chemical compound COCCN ASUDFOJKTJLAIK-UHFFFAOYSA-N 0.000 description 2
- WFJLZWLCGSDPLW-UHFFFAOYSA-N 4-decoxy-2-phenylbenzamide Chemical compound C1(=CC=CC=C1)C1=C(C(=O)N)C=CC(=C1)OCCCCCCCCCC WFJLZWLCGSDPLW-UHFFFAOYSA-N 0.000 description 2
- BPZVSOOQLVSCDF-UHFFFAOYSA-N 4-methylsulfanyl-3-nitrobenzoic acid Chemical compound CSC1=CC=C(C(O)=O)C=C1[N+]([O-])=O BPZVSOOQLVSCDF-UHFFFAOYSA-N 0.000 description 2
- SUGHWWAVYCGJGH-UHFFFAOYSA-N 4-methylsulfanyl-n-(2-methylsulfanylethyl)-3-nitrobenzamide Chemical group CSCCNC(=O)C1=CC=C(SC)C([N+]([O-])=O)=C1 SUGHWWAVYCGJGH-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- CNJJSTPBUHAEFH-UHFFFAOYSA-N methyl 4-fluoro-3-nitrobenzoate Chemical compound COC(=O)C1=CC=C(F)C([N+]([O-])=O)=C1 CNJJSTPBUHAEFH-UHFFFAOYSA-N 0.000 description 2
- NMYUSSVMHPWMIT-UHFFFAOYSA-N n-butyl-4-methylsulfanyl-3-nitrobenzamide Chemical group CCCCNC(=O)C1=CC=C(SC)C([N+]([O-])=O)=C1 NMYUSSVMHPWMIT-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 description 1
- LDKSCZJUIURGMW-UHFFFAOYSA-N 1-isothiocyanato-3-methylsulfanylpropane Chemical group CSCCCN=C=S LDKSCZJUIURGMW-UHFFFAOYSA-N 0.000 description 1
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- CYWGSFFHHMQKET-UHFFFAOYSA-N 2-methylsulfanylethanamine Chemical compound CSCCN CYWGSFFHHMQKET-UHFFFAOYSA-N 0.000 description 1
- VCFGDHUCAOASTJ-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-ethoxy-n-ethylbenzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCC)=CC=C1OCC VCFGDHUCAOASTJ-UHFFFAOYSA-N 0.000 description 1
- KDRHKRNZFSSJTJ-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-ethoxy-n-methylbenzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NC)=CC=C1OCC KDRHKRNZFSSJTJ-UHFFFAOYSA-N 0.000 description 1
- QIFWEPSAXMJPBL-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-ethylsulfanyl-n-(2-methylsulfanylethyl)benzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCCSC)=CC=C1SCC QIFWEPSAXMJPBL-UHFFFAOYSA-N 0.000 description 1
- DYBVMVMELCPFHK-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-methoxy-n-(2-methoxyethyl)benzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCCOC)=CC=C1OC DYBVMVMELCPFHK-UHFFFAOYSA-N 0.000 description 1
- VZFAUTOHTSPTCS-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-methoxy-n-(2-piperidin-1-ylethyl)benzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCCN2CCCCC2)=CC=C1OC VZFAUTOHTSPTCS-UHFFFAOYSA-N 0.000 description 1
- DFUJEAUAAZNMSN-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-methoxy-n-(2-pyridin-4-ylethyl)benzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCCC=2C=CN=CC=2)=CC=C1OC DFUJEAUAAZNMSN-UHFFFAOYSA-N 0.000 description 1
- DFQKJENKIVALRX-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-methoxy-n-(3-methyl-1,2-thiazol-5-yl)benzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NC=2SN=C(C)C=2)=CC=C1OC DFQKJENKIVALRX-UHFFFAOYSA-N 0.000 description 1
- YYBWYWAWIBFDDH-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-methoxy-n-(3-methylbutyl)benzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCCC(C)C)=CC=C1OC YYBWYWAWIBFDDH-UHFFFAOYSA-N 0.000 description 1
- JIVKQNAYQXZMIU-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-methoxy-n-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NC=2SC(C)=NN=2)=CC=C1OC JIVKQNAYQXZMIU-UHFFFAOYSA-N 0.000 description 1
- OMTYNADTVFPCES-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-methoxy-n-(pyridin-2-ylmethyl)benzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCC=2N=CC=CC=2)=CC=C1OC OMTYNADTVFPCES-UHFFFAOYSA-N 0.000 description 1
- HDKCTPWNVRCOCJ-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-4-methylsulfanyl-n-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NC=2SC(C)=NN=2)=CC=C1SC HDKCTPWNVRCOCJ-UHFFFAOYSA-N 0.000 description 1
- SXOGYRGHEYCBGR-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-n-(2-methoxyethyl)-4-methylbenzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCCOC)=CC=C1C SXOGYRGHEYCBGR-UHFFFAOYSA-N 0.000 description 1
- YWQSRBUZAXAYEE-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-n-(2-methoxyethyl)-4-propoxybenzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCCOC)=CC=C1OCCC YWQSRBUZAXAYEE-UHFFFAOYSA-N 0.000 description 1
- PFPVHAFZIQZYEI-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-n-(2-methoxyethyl)-4-propylbenzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCCOC)=CC=C1CCC PFPVHAFZIQZYEI-UHFFFAOYSA-N 0.000 description 1
- ZAXUCMNSZSJDQG-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-n-(2-methylsulfanylethyl)-4-propan-2-ylbenzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCCSC)=CC=C1C(C)C ZAXUCMNSZSJDQG-UHFFFAOYSA-N 0.000 description 1
- MLBJNMKBCPASBG-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-n-(4,6-dimethylpyridin-2-yl)-4-methoxybenzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NC=2N=C(C)C=C(C)C=2)=CC=C1OC MLBJNMKBCPASBG-UHFFFAOYSA-N 0.000 description 1
- JAQGVHVFMYGLOR-UHFFFAOYSA-N 3-[(4-decoxybenzoyl)amino]-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-methoxybenzamide Chemical compound C1=CC(OCCCCCCCCCC)=CC=C1C(=O)NC1=CC(C(=O)NCC2N(CCC2)CC)=CC=C1OC JAQGVHVFMYGLOR-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898921792A GB8921792D0 (en) | 1989-09-27 | 1989-09-27 | New compositions of matter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD295344A5 true DD295344A5 (de) | 1991-10-31 |
Family
ID=10663679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD90344265A DD295344A5 (de) | 1989-09-27 | 1990-09-27 | Benzanilide |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5159114A (cs) |
| EP (1) | EP0424194B1 (cs) |
| JP (1) | JPH03178954A (cs) |
| KR (1) | KR910006219A (cs) |
| AT (1) | ATE110715T1 (cs) |
| AU (1) | AU641686B2 (cs) |
| CA (1) | CA2026273A1 (cs) |
| CS (1) | CS465690A3 (cs) |
| DD (1) | DD295344A5 (cs) |
| DE (1) | DE69012040T2 (cs) |
| DK (1) | DK0424194T3 (cs) |
| ES (1) | ES2058849T3 (cs) |
| FI (1) | FI904728A7 (cs) |
| GB (1) | GB8921792D0 (cs) |
| HU (1) | HU207839B (cs) |
| IE (1) | IE903448A1 (cs) |
| IL (1) | IL95762A0 (cs) |
| MX (1) | MX9203712A (cs) |
| NO (1) | NO173057C (cs) |
| NZ (1) | NZ235454A (cs) |
| PL (1) | PL163034B1 (cs) |
| PT (1) | PT95439A (cs) |
| RU (1) | RU2007389C1 (cs) |
| ZA (1) | ZA907639B (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9016581D0 (en) * | 1990-07-27 | 1990-09-12 | Ici Plc | Fungicides |
| GB9017710D0 (en) * | 1990-08-13 | 1990-09-26 | May & Baker Ltd | New compositions of matter |
| DE4200259A1 (de) * | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
| AU672699B2 (en) * | 1993-06-30 | 1996-10-10 | Sankyo Company Limited | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
| GB9408185D0 (en) * | 1994-04-25 | 1994-06-15 | Fujisawa Pharmaceutical Co | New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same |
| DE19701694A1 (de) * | 1997-01-20 | 1998-07-23 | Asta Medica Ag | Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung |
| FR2946345B1 (fr) | 2009-06-05 | 2011-05-20 | Galderma Res & Dev | Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
| FR2946346B1 (fr) | 2009-06-05 | 2011-05-20 | Galderma Res & Dev | Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
| FR2946340B1 (fr) | 2009-06-05 | 2011-06-24 | Galderma Res & Dev | Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
| FR2946342B1 (fr) | 2009-06-05 | 2011-06-24 | Galderma Res & Dev | Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1438612A (en) * | 1974-02-08 | 1976-06-09 | Biorex Laboratories Ltd | Glycyrrhetinic acid derivatives |
| AU547405B2 (en) * | 1981-07-08 | 1985-10-17 | Sanofi | Amidobenzamides |
| US4500714A (en) * | 1981-10-15 | 1985-02-19 | Chugai Seiyaku Kabushiki Kaisha | 3-Substituted-ureido-N-pyridyl benzamides |
| AU567140B2 (en) * | 1984-01-06 | 1987-11-12 | Shionogi & Co., Ltd. | Sulphonamido-benzamide derivatives |
| LU86258A1 (fr) * | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
| US4835181A (en) * | 1987-02-18 | 1989-05-30 | Eli Lilly And Company | Anticonvulsant agents using cyano dimethylphenyl benzamides |
-
1989
- 1989-09-27 GB GB898921792A patent/GB8921792D0/en active Pending
-
1990
- 1990-09-24 IL IL95762A patent/IL95762A0/xx unknown
- 1990-09-25 NZ NZ235454A patent/NZ235454A/en unknown
- 1990-09-25 ZA ZA907639A patent/ZA907639B/xx unknown
- 1990-09-25 KR KR1019900015212A patent/KR910006219A/ko not_active Withdrawn
- 1990-09-25 DE DE69012040T patent/DE69012040T2/de not_active Expired - Fee Related
- 1990-09-25 AU AU63133/90A patent/AU641686B2/en not_active Ceased
- 1990-09-25 CS CS904656A patent/CS465690A3/cs unknown
- 1990-09-25 IE IE344890A patent/IE903448A1/en unknown
- 1990-09-25 EP EP90402635A patent/EP0424194B1/en not_active Expired - Lifetime
- 1990-09-25 JP JP2252053A patent/JPH03178954A/ja active Pending
- 1990-09-25 ES ES90402635T patent/ES2058849T3/es not_active Expired - Lifetime
- 1990-09-25 AT AT90402635T patent/ATE110715T1/de not_active IP Right Cessation
- 1990-09-25 DK DK90402635.8T patent/DK0424194T3/da active
- 1990-09-26 NO NO904187A patent/NO173057C/no unknown
- 1990-09-26 HU HU906230A patent/HU207839B/hu not_active IP Right Cessation
- 1990-09-26 CA CA002026273A patent/CA2026273A1/en not_active Abandoned
- 1990-09-26 FI FI904728A patent/FI904728A7/fi not_active Application Discontinuation
- 1990-09-26 RU SU904831109A patent/RU2007389C1/ru active
- 1990-09-27 DD DD90344265A patent/DD295344A5/de not_active IP Right Cessation
- 1990-09-27 PL PL90287073A patent/PL163034B1/pl unknown
- 1990-09-27 PT PT95439A patent/PT95439A/pt not_active Application Discontinuation
-
1991
- 1991-08-05 US US07/742,493 patent/US5159114A/en not_active Expired - Fee Related
-
1992
- 1992-06-29 MX MX9203712A patent/MX9203712A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5159114A (en) | 1992-10-27 |
| AU6313390A (en) | 1991-04-11 |
| FI904728A7 (fi) | 1991-03-28 |
| JPH03178954A (ja) | 1991-08-02 |
| HU207839B (en) | 1993-06-28 |
| EP0424194B1 (en) | 1994-08-31 |
| PL287073A1 (en) | 1991-11-04 |
| CA2026273A1 (en) | 1991-03-28 |
| CS465690A3 (en) | 1992-04-15 |
| RU2007389C1 (ru) | 1994-02-15 |
| PL163034B1 (pl) | 1994-02-28 |
| IE903448A1 (en) | 1991-04-10 |
| HUT55349A (en) | 1991-05-28 |
| DK0424194T3 (da) | 1994-10-03 |
| AU641686B2 (en) | 1993-09-30 |
| NZ235454A (en) | 1992-04-28 |
| NO173057B (no) | 1993-07-12 |
| MX9203712A (es) | 1992-07-01 |
| DE69012040D1 (de) | 1994-10-06 |
| EP0424194A2 (en) | 1991-04-24 |
| NO904187D0 (no) | 1990-09-26 |
| PT95439A (pt) | 1991-05-22 |
| GB8921792D0 (en) | 1989-11-08 |
| ZA907639B (en) | 1991-07-31 |
| NO173057C (no) | 1993-10-20 |
| IL95762A0 (en) | 1991-06-30 |
| ES2058849T3 (es) | 1994-11-01 |
| FI904728A0 (fi) | 1990-09-26 |
| HU906230D0 (en) | 1991-03-28 |
| EP0424194A3 (en) | 1991-09-25 |
| KR910006219A (ko) | 1991-04-27 |
| NO904187L (no) | 1991-04-02 |
| ATE110715T1 (de) | 1994-09-15 |
| DE69012040T2 (de) | 1995-01-05 |
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| ENJ | Ceased due to non-payment of renewal fee |