DD299028A5 - BACTERICIDE MEDIUM - Google Patents

Abstract

The invention relates to bactericidal agents which can be used in crop and storage protection. The aim and object of the invention is to expand the state of the art with new agents which are superior in their effect and can be used with low concentrations of active substance. According to the invention, substituted benzonitriles are used as the active ingredient. These are particularly suitable for applications where resistance phenomena have already occurred with known agents. {Bactericidal agent; substituted benzonitriles; very good effect; low application concentration; against sporulating and non-sporulating bacteria; combinable with other plant protection products}

Description

means

in addition to common excipients and carriers included.

2. means still point! ", Characterized in that at least one of the following substituted Benzop.itrile

3,5-Dibroi ^v, -4-hydroxybenzonitrile 3,5-diiodo- _'t -acetoxybenzonitril 3-iodo-5-nitro-4-butyroxybenzonitril 3-iodo-5-ritro-4-benzoyloxybenzonitril 3-nitro-4 hydroxybenzonitri!

3-bromo-'5nitro-4-hydroxybenzonitrile is included as an active ingredient.

Field of application dnr invention

The present invention relates to bactericidal agents which can be used in crop and storage protection.

Characteristic of the known technical solutions

For the control of bacteria diverse active ingredients and commercial preparations are known.

Due to relatively fast resistance training of the bacteria is a frequent drug change and the application of drug mixture ^ necessary.

On the basis of the basic structure of the phenol, a variety of bactericidal compounds are described, e.g. in DE-OS 1492726, where p-Hydroxybenzoesäuraester for preservation of canned food use findsn.

These compounds have the disadvantages of too high an application concentration, a too low long-term effect and a lack of latitude.

Object of the invention

The aim of the invention is the extension of the state of the art by new bactericidal agents for applications where already Resistenzeif.cheinungen have occurred.

Explanation of the essence of the invention

The object of the invention is the search for substituted phenols which are superior in their bactericidal action to previously known active substances and achieve a comparatively higher effect in low application concentrations.

It has been found that compounds of the type of the general formula ₍

E ₁

R ₁ , R ₂ : H, Hal and / or NO ₂ R ₃ : H, -C-Alkoder-C-Aryl

mean, against sporulating and non-sporulating bacteria have very good bactericidal effects that are superior to comparable drugs.

Preferably, the following active ingredients are particularly suitable:

3,5-dibromo-4-hydroxybenzonitrile 3,5-diiodo-4-acetoxybenzonitrile 3-iodo-5-nitro-4-butyroxybenzonitrile 3-iodo-5-nitro-4-benzyloxybenzonitrile 3-nitro-4-hydroxybenzonitrile 3-bromo -5-nitro-4-hydroxybenzonitrile

Diq active ingredients can be converted by customary methods into application-formulated formulations, for. B. in the form of emulsion concentrates, solutions, wettable powders, etc.

For this purpose, they are mixed in a known manner with liquid or solid carriers and optionally added surface-active compounds.

The application and the application rates of the funds depend on the particular field of application, the type of formulation and the desired breadth and depth effect. The application takes place z. 3. by addition, pouring, brushing, spraying or spreading.

The agents according to the invention can be combined with other active ingredients to expand the range of use and be used together with other crop protection agents, fertilizers and growth regulators. The agents according to the invention can also be added as agents for protection against bacteria and their destructive effects paints, plastics, cooling emulsion, etc. The following examples illustrate the good effect of the agents according to the invention.

AusiOhrungsbelspiele

example 1

Composition of emulsion concentrates:

10% of an active ingredient according to the invention 10% Dispersal L 80% xylene

Example 2

Agar plate test

The nutrient stock I (immuno-preparations Berlin) is used for stammering and breeding with the following; Composition:

Pancreatic peptone (meat, fish) 20 g / l sodium chloride 5 g / l Agar for culture media 12 g / l PH value 7.2

The active ingredient formulations are added to the liquid, sterile agar so that the desired active substance concentration in the medium is achieved. The active ingredient-containing agar is poured into plates and inoculated after cooling with the appropriate bacterial culture in the strip test procedure. The inhibition of growth (breadth of the bacterial Mifida) is expressed in% of the control cultures without added active substance.

Agar plate test with Staphylococcus oureus

connection Active substance concentration mg χ 1 "' Example 3 Agar plate assay with Bacillus mycoldes Active substance concentration mg χ Γ ¹ Inhibition% 4-hydroxybenzoic acid ethyl ester (known) 100 250 500 1000 connection 100 250 500 1000 17 20 20 100 3,5-dibromo-4-hydroxybenzonitrile 100 4-hydroxybonoic acid ethyl ester (known) 100 250 100 SBrom-δ-nitro-hydroxybenzonitrile 100 250 3,5-dibromo-4-hydroxybenzonitrile 100 250 500 20 100 3,5-diiodo-4-acetoxybenzonitrile 100 3-nitro-4-hydroxybenzonitrile 100 100 3-nitro-4-acetoxybenzonitrile 100 100 S.S-diiodoacetoxybenzonitrile 100 250 20 100 3,5-diiodo-4-butyroxybenzonitri! 100 S-iodo-O-nitro-acetoxybenzonitrile 100 100 3-iodo-5-nitro-4-butyroxybenzonitrile 100 3-iodo-5-nitro-4-butyroxybenzonitrile 100 250 500 100 S.ö-dichloro-benzoyloxybenzonitrile 100 250 500 3-nitro-4-butyroxybenzonitrile 100 0 87 100 3-iodo-5-nitro-4-benzoyl-oxybenzonitrile 100 3-iodo-5-nitro-4-benzoyl-cxybenzonitrile ιυο 250 500 100 3-nitro-4-benzoyloxybenzonitrile Inhibition% 8 13 66 100 31 100 47 95 100 100 13 100 100 53 9b 100 100 40 95 100

Claims (1)

1. Bactericidal agent, characterized in that it contains at least one substituted Benzonitri as active ingredients! the general formula I, 0-IU ' X. ^{3 ΑΙ} Ρ ^ ~ "ρ · .λ!" J ON in the R ₁₁ R ₂ : H, Haland / odfirNO ₂ R ₃ : Η, -C-Alkodö'-C-aryl O O