DE10347311A1 - Method and device for carrying out reactions - Google Patents

Method and device for carrying out reactions Download PDF

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Publication number
DE10347311A1
DE10347311A1 DE2003147311 DE10347311A DE10347311A1 DE 10347311 A1 DE10347311 A1 DE 10347311A1 DE 2003147311 DE2003147311 DE 2003147311 DE 10347311 A DE10347311 A DE 10347311A DE 10347311 A1 DE10347311 A1 DE 10347311A1
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Germany
Prior art keywords
reaction
carrying
out reactions
time
path
Prior art date
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Application number
DE2003147311
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German (de)
Inventor
Wolfgang Ehrfeld
Karoly Nagy
Alexander Azzawi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ehrfeld Mikrotechnik BTS GmbH
Original Assignee
EHRFELD MIKROTECHNIK AG
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Application filed by EHRFELD MIKROTECHNIK AG filed Critical EHRFELD MIKROTECHNIK AG
Priority to DE2003147311 priority Critical patent/DE10347311A1/en
Priority to EP04765899A priority patent/EP1673161A1/en
Priority to PCT/EP2004/011291 priority patent/WO2005035110A1/en
Publication of DE10347311A1 publication Critical patent/DE10347311A1/en
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
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    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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Abstract

Die Erfindung betrifft eine Vorrichtung zur Durchführung von Reaktionen mit Reagenzmengen im Bereich von 0,5 bis 10 nmol, bei der die Reagenzien über Dosierstationen (5, 9, 11, 13) an Reaktionsorte (3) dosiert werden, die sich entlang einer Reaktionsstrecke (2) bewegen, wobei mindestens eine Dosierstation (5, 9, 11, 13) und eine Entnahmestelle (16) derart angeordnet sind, dass die Zeit, in der sich die Reaktionsorte (3) auf der Reaktionsstrecke (2) bewegen, mindestens der erforderlichen Reaktionszeit für einen Reaktionsschritt entspricht.The invention relates to a device for carrying out reactions with reagent amounts in the range of 0.5 to 10 nmol, in which the reagents are dosed via metering stations (5, 9, 11, 13) to reaction sites (3) which extend along a reaction path (FIG. 2), wherein at least one dosing station (5, 9, 11, 13) and a removal point (16) are arranged such that the time in which the reaction sites (3) move on the reaction path (2), at least the required Reaction time for one reaction step.

DE2003147311 2003-10-08 2003-10-08 Method and device for carrying out reactions Withdrawn DE10347311A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE2003147311 DE10347311A1 (en) 2003-10-08 2003-10-08 Method and device for carrying out reactions
EP04765899A EP1673161A1 (en) 2003-10-08 2004-10-08 Method and device for carrying out reactions
PCT/EP2004/011291 WO2005035110A1 (en) 2003-10-08 2004-10-08 Method and device for carrying out reactions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2003147311 DE10347311A1 (en) 2003-10-08 2003-10-08 Method and device for carrying out reactions

Publications (1)

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DE10347311A1 true DE10347311A1 (en) 2005-05-12

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DE2003147311 Withdrawn DE10347311A1 (en) 2003-10-08 2003-10-08 Method and device for carrying out reactions

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EP (1) EP1673161A1 (en)
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