DE2139082A1 - Substituierte pyrimidine, verfahren zu deren herstellung und sie enthaltende arzneimittel - Google Patents

Substituierte pyrimidine, verfahren zu deren herstellung und sie enthaltende arzneimittel

Info

Publication number: DE2139082A1
Authority: DE; Germany
Prior art keywords: group; methyl; hydrogen atom; atom; carbon atoms
Prior art date: 1971-08-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

DE19712139082

Other languages

German (de)

English (en)

Inventor

Kurt Dipl Chem Dr Klemm

Wolfgang Dipl Chem Dr Pruesse

Wolfgang Dr Med Schoetensack

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Takeda GmbH

Original Assignee

Byk Gulden Lomberg Chemische Fabrik GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-08-04

Filing date

1971-08-04

Publication date

1973-02-15

Priority to BE787125D priority Critical patent/BE787125A/fr

1971-08-04 Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH

1971-08-04 Priority to DE19712139082 priority patent/DE2139082A1/de

1972-08-01 Priority to LU65836A priority patent/LU65836A1/xx

1972-08-02 Priority to FR7227858A priority patent/FR2150722A1/fr

1972-08-03 Priority to JP7799272A priority patent/JPS4826777A/ja

1972-08-03 Priority to NL7210636A priority patent/NL7210636A/xx

1973-02-15 Publication of DE2139082A1 publication Critical patent/DE2139082A1/de

Status Pending legal-status Critical Current

Links

238000004519 manufacturing process Methods 0.000 title description 7
229940126601 medicinal product Drugs 0.000 title 1
-1 hydrocarbon radical Chemical class 0.000 claims description 52
150000001875 compounds Chemical class 0.000 claims description 48
150000003839 salts Chemical class 0.000 claims description 44
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 40
125000004432 carbon atom Chemical group C* 0.000 claims description 34
238000000034 method Methods 0.000 claims description 27
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 24
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
150000003230 pyrimidines Chemical class 0.000 claims description 20
125000003545 alkoxy group Chemical group 0.000 claims description 18
125000000217 alkyl group Chemical group 0.000 claims description 16
150000003254 radicals Chemical class 0.000 claims description 16
239000003814 drug Substances 0.000 claims description 14
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238000006243 chemical reaction Methods 0.000 claims description 13
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CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 3
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KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 4
239000002585 base Substances 0.000 description 4
238000004440 column chromatography Methods 0.000 description 4
239000006185 dispersion Substances 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
229910000104 sodium hydride Inorganic materials 0.000 description 4
239000012312 sodium hydride Substances 0.000 description 4
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125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 3
239000012071 phase Substances 0.000 description 3
239000000454 talc Substances 0.000 description 3
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LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
LRHPLDYGYMQRHN-UHFFFAOYSA-N n-Butanol Substances CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
230000000933 noradrenolytic effect Effects 0.000 description 1
229960002748 norepinephrine Drugs 0.000 description 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
UWBHMRBRLOJJAA-UHFFFAOYSA-N oxaluric acid Chemical compound NC(=O)NC(=O)C(O)=O UWBHMRBRLOJJAA-UHFFFAOYSA-N 0.000 description 1
QMMOXUPEWRXHJS-UHFFFAOYSA-N pent-2-ene Chemical group CCC=CC QMMOXUPEWRXHJS-UHFFFAOYSA-N 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000004742 propyloxycarbonyl group Chemical group 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
125000005920 sec-butoxy group Chemical group 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
230000001624 sedative effect Effects 0.000 description 1
239000007787 solid Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000006318 tert-butyl amino group Chemical group [H]N(*)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE19712139082 1971-08-04 1971-08-04 Substituierte pyrimidine, verfahren zu deren herstellung und sie enthaltende arzneimittel Pending DE2139082A1 (de)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
BE787125D BE787125A (fr)	1971-08-04		Pyrimidines substituees, leurs procedes de preparation et medicaments les contenant
DE19712139082 DE2139082A1 (de)	1971-08-04	1971-08-04	Substituierte pyrimidine, verfahren zu deren herstellung und sie enthaltende arzneimittel
LU65836A LU65836A1 (fr)	1971-08-04	1972-08-01
FR7227858A FR2150722A1 (en)	1971-08-04	1972-08-02	Substd pyrimidines - hypotensives and analgesics
JP7799272A JPS4826777A (fr)	1971-08-04	1972-08-03
NL7210636A NL7210636A (fr)	1971-08-04	1972-08-03

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19712139082 DE2139082A1 (de)	1971-08-04	1971-08-04	Substituierte pyrimidine, verfahren zu deren herstellung und sie enthaltende arzneimittel

Publications (1)

Publication Number	Publication Date
DE2139082A1 true DE2139082A1 (de)	1973-02-15

Family

ID=5815787

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE19712139082 Pending DE2139082A1 (de)	1971-08-04	1971-08-04	Substituierte pyrimidine, verfahren zu deren herstellung und sie enthaltende arzneimittel

Country Status (6)

Country	Link
JP (1)	JPS4826777A (fr)
BE (1)	BE787125A (fr)
DE (1)	DE2139082A1 (fr)
FR (1)	FR2150722A1 (fr)
LU (1)	LU65836A1 (fr)
NL (1)	NL7210636A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4425143A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Substituierte Pyrimidinverbindungen und deren Verwendung

0
- BE BE787125D patent/BE787125A/fr unknown
1971
- 1971-08-04 DE DE19712139082 patent/DE2139082A1/de active Pending
1972
- 1972-08-01 LU LU65836A patent/LU65836A1/xx unknown
- 1972-08-02 FR FR7227858A patent/FR2150722A1/fr not_active Withdrawn
- 1972-08-03 NL NL7210636A patent/NL7210636A/xx unknown
- 1972-08-03 JP JP7799272A patent/JPS4826777A/ja active Pending

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4425143A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Substituierte Pyrimidinverbindungen und deren Verwendung
WO1996002519A1 (fr) *	1994-07-15	1996-02-01	Basf Aktiengesellschaft	Composes substitues de pyrimidine et leur utilisation

Also Published As

Publication number	Publication date
BE787125A (fr)	1973-02-05
FR2150722A1 (en)	1973-04-13
LU65836A1 (fr)	1973-08-17
JPS4826777A (fr)	1973-04-09
NL7210636A (fr)	1973-02-06

Publication	Publication Date	Title
DE1695556C3 (de)	1981-06-25	3-Alkyl-1,2,3,4,4a,9-hexahydropyrazino[1,2-f]morphanthridinderivate
DE2366106C2 (de)	1980-02-14	2-Amino-6,7-dimethoxy-4-(methoxysubstituierte-lÄ3»4-tetrahydroisochinolin-2-yl)-chinazolinderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2504565A1 (de)	1975-08-14	Neue derivate von 1h-imidazo(4,5-c) pyridin-7-carboxylsaeuren und -saeureestern
WO1980000152A1 (fr)	1980-02-07	Derives d'un 3-aminopropoxy-aryle, leur preparation et utilisation
DE2226703A1 (de)	1973-12-13	Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung
EP0163260A1 (fr)	1985-12-04	Nouvelles pyrrolidones substituées, procédé pour leur préparation et médicaments
EP0180115A2 (fr)	1986-05-07	1,2,4-Triazolyl carbamates et leurs sels d'addition acides, procédé pour leur préparation et médicaments
DE2523103A1 (de)	1976-12-09	Neue propargyl-2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
EP1326842A1 (fr)	2003-07-16	Derives d'arylpiperazine et leur utilisation comme medicaments psychotropes
DE2658558A1 (de)	1978-06-29	Diazabicyclo(3,3,1)nonane, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2143730A1 (de)	1973-03-08	Substituierte pyridine, verfahren zu deren herstellung und sie enthaltende arzneimittel
DE2431609A1 (de)	1975-01-30	Neue sulfamoylbenzoesaeureamide
DE3427985A1 (de)	1986-01-30	Neue 2h-l-benzopyran-2-on-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
EP0056866A2 (fr)	1982-08-04	Dérivés phénylpipérazines d'hétarylphénoles et d'hétarylanilines, leur préparation et leurs compositions pharmaceutiques
DE2364685A1 (de)	1975-07-03	Phenoxyalkylamine und verfahren zu ihrer herstellung
EP0124630B1 (fr)	1987-01-28	Dérivés de pyrimidinothioalkyle pyridine, procédé pour leur préparation et médicaments contenant ces composés
DE2139082A1 (de)	1973-02-15	Substituierte pyrimidine, verfahren zu deren herstellung und sie enthaltende arzneimittel
DE2139083A1 (de)	1973-02-15	Substituierte pyrimidine, verfahren zu deren herstellung und sie enthaltende arzneimittel
EP0212551B1 (fr)	1990-10-24	Composés tétraoxo
EP0088323B1 (fr)	1987-05-06	Amides d'acides imidazothiadiazolealcanecarboxyliques, produits intermédiaires pour leur fabrication, leur fabrication et leur application en médicaments
DE2258403A1 (de)	1973-06-07	Basisch substituierte chinazolon-(2)derivate, verfahren zu deren herstellung und sie enthaltende arzneimittel
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DE1620368A1 (de)	1970-04-02	Verfahren zur Herstellung neuer heterocyclischer Verbindungen
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