DE60123115D1 - Verfahren für die synthese eines lhrh peptides - Google Patents

Verfahren für die synthese eines lhrh peptides

Info

Publication number: DE60123115D1
Authority: DE; Germany
Prior art keywords: peptide; synthesis; lhrh peptide; protecting group; residue
Prior art date: 2000-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60123115T

Other languages

English (en)

Other versions

DE60123115T2 (de

Inventor

Allen Jackson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ipsen Manufacturing Ireland Ltd

Original Assignee

Ipsen Manufacturing Ireland Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-22

Filing date

2001-12-19

Publication date

2006-10-26

2001-12-19 Application filed by Ipsen Manufacturing Ireland Ltd filed Critical Ipsen Manufacturing Ireland Ltd

2006-10-26 Publication of DE60123115D1 publication Critical patent/DE60123115D1/de

2007-03-29 Application granted granted Critical

2007-03-29 Publication of DE60123115T2 publication Critical patent/DE60123115T2/de

2021-12-20 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 title 1
102100024028 Progonadoliberin-1 Human genes 0.000 title 1
101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
125000006239 protecting group Chemical group 0.000 abstract 2
238000003776 cleavage reaction Methods 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/068—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for heterocyclic side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE60123115T 2000-12-22 2001-12-19 Verfahren für die synthese eines lhrh peptides Expired - Lifetime DE60123115T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IE20001079		2000-12-22
IE20001079		2000-12-22
PCT/IE2001/000159 WO2002051861A2 (en)	2000-12-22	2001-12-19	Process for the synthesis of a peptide having a tryptophan residue

Publications (2)

Publication Number	Publication Date
DE60123115D1 true DE60123115D1 (de)	2006-10-26
DE60123115T2 DE60123115T2 (de)	2007-03-29

Family

ID=11042704

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60123115T Expired - Lifetime DE60123115T2 (de)	2000-12-22	2001-12-19	Verfahren für die synthese eines lhrh peptides

Country Status (24)

Country	Link
US (1)	US7122628B2 (de)
EP (1)	EP1343808B1 (de)
JP (1)	JP4064817B2 (de)
KR (1)	KR100591832B1 (de)
CN (2)	CN1481389A (de)
AT (1)	ATE339442T1 (de)
AU (1)	AU2002222439C1 (de)
BR (1)	BR0116447B1 (de)
CA (1)	CA2432708C (de)
CZ (1)	CZ299141B6 (de)
DE (1)	DE60123115T2 (de)
DK (1)	DK1343808T3 (de)
ES (1)	ES2266104T3 (de)
HU (2)	HU230601B1 (de)
IE (1)	IES20011090A2 (de)
IL (2)	IL156258A0 (de)
MX (1)	MXPA03005678A (de)
NO (1)	NO325038B1 (de)
NZ (1)	NZ526990A (de)
PL (1)	PL205949B1 (de)
PT (1)	PT1343808E (de)
RU (1)	RU2276156C2 (de)
WO (1)	WO2002051861A2 (de)
ZA (1)	ZA200304809B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7091311B2 (en)	1996-06-07	2006-08-15	Smithkline Beecham Corporation	Peptides and compounds that bind to a receptor
ES2781475T3 (es)	2002-09-18	2020-09-02	Janssen Pharmaceuticals Inc	Métodos para aumentar la producción de células madre hematopoyéticas y plaquetas
SG131110A1 (en) *	2003-08-28	2007-04-26	Ortho Mcneil Pharm Inc	Peptides and compounds that bind to thrombopoietin receptors
WO2007077112A1 (en) *	2005-12-30	2007-07-12	F. Hoffmann-La Roche Ag	Methods for the synthesis of arginine-containing peptides
WO2014047822A1 (zh) *	2012-09-27	2014-04-03	深圳翰宇药业股份有限公司	一种制备布舍瑞林的方法
US9969769B2 (en)	2014-12-19	2018-05-15	Cem Corporation	Coupling method for peptide synthesis at elevated temperatures
US10308677B2 (en)	2014-12-19	2019-06-04	Cem Corporation	Coupling method for peptide synthesis at elevated temperatures

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4211693A (en)	1977-09-20	1980-07-08	The Salk Institute For Biological Studies	Peptides with para-substituted phenylalanine
US4569927A (en) *	1984-02-23	1986-02-11	The Salk Institute For Biological Studies	GnRH Antagonists IV
IL74827A (en)	1984-05-21	1989-06-30	Salk Inst For Biological Studi	Peptides active as gnrh antagonists and pharmaceutical compositions containing them
IT1203600B (it)	1985-12-06	1989-02-15	Phidea Srl	Metodo per preparare il (d-trp6)-lhrh
GB8822502D0 (en)	1988-09-24	1988-10-26	Expansia Sa	New peptide synthesis method
US5175254A (en) *	1988-09-24	1992-12-29	Societe D'expansion Scientifque Expansia	Solid phase peptide synthesis using a polyacrylic support in aqueous solution
RU2043362C1 (ru) *	1991-08-12	1995-09-10	Синтекс (Ю-Эс-Эй) Инк.	Способ твердофазного синтеза пептидов
JPH05331188A (ja)	1992-05-28	1993-12-14	Nippon Chemiphar Co Ltd	トリペプチド、その製造方法及びエンドセリン拮抗剤
RU2086561C1 (ru) *	1995-09-25	1997-08-10	Тихонов Александр Васильевич	Способ получения нонапептидэтиламида

2001
- 2001-12-19 CZ CZ20031634A patent/CZ299141B6/cs not_active IP Right Cessation
- 2001-12-19 US US10/451,486 patent/US7122628B2/en not_active Expired - Lifetime
- 2001-12-19 CN CNA018210384A patent/CN1481389A/zh active Pending
- 2001-12-19 KR KR1020037008232A patent/KR100591832B1/ko not_active Expired - Lifetime
- 2001-12-19 WO PCT/IE2001/000159 patent/WO2002051861A2/en not_active Ceased
- 2001-12-19 DE DE60123115T patent/DE60123115T2/de not_active Expired - Lifetime
- 2001-12-19 DK DK01272223T patent/DK1343808T3/da active
- 2001-12-19 CN CNA2007100047879A patent/CN101003563A/zh active Pending
- 2001-12-19 NZ NZ526990A patent/NZ526990A/xx not_active IP Right Cessation
- 2001-12-19 AT AT01272223T patent/ATE339442T1/de active
- 2001-12-19 PL PL361993A patent/PL205949B1/pl unknown
- 2001-12-19 JP JP2002552954A patent/JP4064817B2/ja not_active Expired - Lifetime
- 2001-12-19 RU RU2003122779/04A patent/RU2276156C2/ru not_active IP Right Cessation
- 2001-12-19 HU HUP1400157A patent/HU230601B1/hu unknown
- 2001-12-19 IL IL15625801A patent/IL156258A0/xx active IP Right Grant
- 2001-12-19 EP EP01272223A patent/EP1343808B1/de not_active Expired - Lifetime
- 2001-12-19 HU HU0302633A patent/HU229701B1/hu unknown
- 2001-12-19 MX MXPA03005678A patent/MXPA03005678A/es active IP Right Grant
- 2001-12-19 CA CA2432708A patent/CA2432708C/en not_active Expired - Lifetime
- 2001-12-19 BR BRPI0116447-3B1A patent/BR0116447B1/pt active IP Right Grant
- 2001-12-19 ES ES01272223T patent/ES2266104T3/es not_active Expired - Lifetime
- 2001-12-19 AU AU2002222439A patent/AU2002222439C1/en not_active Expired
- 2001-12-19 PT PT01272223T patent/PT1343808E/pt unknown
- 2001-12-20 IE IE20011090A patent/IES20011090A2/en not_active IP Right Cessation
2003
- 2003-06-02 IL IL156258A patent/IL156258A/en unknown
- 2003-06-20 NO NO20032852A patent/NO325038B1/no not_active IP Right Cessation
- 2003-06-20 ZA ZA200304809A patent/ZA200304809B/en unknown

Also Published As

Publication number	Publication date
NO20032852L (no)	2003-08-22
PL361993A1 (en)	2004-10-18
CZ20031634A3 (cs)	2003-09-17
EP1343808B1 (de)	2006-09-13
HUP0302633A2 (hu)	2003-12-29
NO20032852D0 (no)	2003-06-20
HUP0302633A3 (en)	2008-04-28
AU2002222439C1 (en)	2005-10-27
MXPA03005678A (es)	2003-10-06
NZ526990A (en)	2005-04-29
KR20030081355A (ko)	2003-10-17
BR0116447B1 (pt)	2014-04-29
BR0116447A (pt)	2003-10-07
CN101003563A (zh)	2007-07-25
WO2002051861A2 (en)	2002-07-04
AU2002222439B2 (en)	2005-04-07
WO2002051861A3 (en)	2002-10-10
CA2432708C (en)	2011-07-12
HU230601B1 (hu)	2017-02-28
US20040077827A1 (en)	2004-04-22
IES20011090A2 (en)	2002-12-30
CZ299141B6 (cs)	2008-04-30
PL205949B1 (pl)	2010-06-30
KR100591832B1 (ko)	2006-06-20
ATE339442T1 (de)	2006-10-15
NO325038B1 (no)	2008-01-21
RU2276156C2 (ru)	2006-05-10
CA2432708A1 (en)	2002-07-04
DE60123115T2 (de)	2007-03-29
ZA200304809B (en)	2004-04-20
HUP1400157A2 (en)	2003-12-29
PT1343808E (pt)	2007-01-31
ES2266104T3 (es)	2007-03-01
JP4064817B2 (ja)	2008-03-19
HU229701B1 (en)	2014-05-28
IL156258A0 (en)	2004-01-04
DK1343808T3 (da)	2006-12-11
JP2004516330A (ja)	2004-06-03
RU2003122779A (ru)	2005-02-20
CN1481389A (zh)	2004-03-10
IL156258A (en)	2008-06-05
EP1343808A2 (de)	2003-09-17
US7122628B2 (en)	2006-10-17
HK1055749A1 (en)	2004-01-21

Legal Events

Date	Code	Title	Description
2007-10-04	8364	No opposition during term of opposition

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DE60123115D1 (de)	2006-10-26	Verfahren für die synthese eines lhrh peptides
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CO5210964A1 (es)	2002-10-30	Proceso para la (co)polimerizacion en fase gaseosa de olefinas en un reactor de lecho fluidificado
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DE502004005119D1 (de)	2007-11-15	Verfahren zur Herstellung von TCD-Alkohol DM
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AR027327A1 (es)	2003-03-26	Procedimiento para la separacion einzimatica de racematos de derivados de aminometil-aril-ciclohezanol
Ravindranath et al.	2003	Selective removal of N‐Boc protecting group from aromatic amines using silica gel‐supported sodium hydrogen sulfate and HY‐zeolite as heterogeneous Catalysts [1]
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ATE287399T1 (de)	2005-02-15	Verfahren zur herstellung eines pgd2-antagonisten
IL178228A0 (en)	2006-12-31	A process for the semisynthesis of deserpidine
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