DE60319599D1 - Verfahren zur differenzierung einer mesenchym-stammzelle zu einer nervenzelle sowie die nervenzelle eine neurodegenerative krankheit - Google Patents

Verfahren zur differenzierung einer mesenchym-stammzelle zu einer nervenzelle sowie die nervenzelle eine neurodegenerative krankheit

Info

Publication number: DE60319599D1
Authority: DE; Germany
Prior art keywords: stem cell; differentiating; nervencell; nervencel; neurodeegenerative
Prior art date: 2003-10-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60319599T

Other languages

English (en)

Other versions

DE60319599T8 (de

DE60319599T2 (de

Inventor

Hyun-Soo Kim

Young-Mo Kang

Kyung-Bock Lee

Sang-Kyo Park

Sang-Kap Lee

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

FCB-Pharmicell Co Ltd

Original Assignee

FCB-Pharmicell Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-29

Filing date

2003-10-29

Publication date

2008-04-17

2003-10-29 Application filed by FCB-Pharmicell Co Ltd filed Critical FCB-Pharmicell Co Ltd

2008-04-17 Publication of DE60319599D1 publication Critical patent/DE60319599D1/de

2008-06-26 Application granted granted Critical

2008-06-26 Publication of DE60319599T2 publication Critical patent/DE60319599T2/de

2008-10-16 Publication of DE60319599T8 publication Critical patent/DE60319599T8/de

Status Active legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 3
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
210000000130 stem cell Anatomy 0.000 title 1
210000002901 mesenchymal stem cell Anatomy 0.000 abstract 4
210000003061 neural cell Anatomy 0.000 abstract 2
230000002062 proliferating effect Effects 0.000 abstract 2
102000009024 Epidermal Growth Factor Human genes 0.000 abstract 1
101800003838 Epidermal growth factor Proteins 0.000 abstract 1
102000003745 Hepatocyte Growth Factor Human genes 0.000 abstract 1
108090000100 Hepatocyte Growth Factor Proteins 0.000 abstract 1
210000001130 astrocyte Anatomy 0.000 abstract 1
238000007796 conventional method Methods 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
229940116977 epidermal growth factor Drugs 0.000 abstract 1
210000005087 mononuclear cell Anatomy 0.000 abstract 1
210000002569 neuron Anatomy 0.000 abstract 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Psychology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)

DE60319599T 2003-10-29 2003-10-29 Verfahren zur differenzierung einer mesenchym-stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit Active DE60319599T8 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/KR2003/002302 WO2005040362A1 (en)	2003-10-29	2003-10-29	Method for differentiating mesenchymal stem cell into neural cell and pharmaceutical composition containing the neural cell for neurodegenerative disease

Publications (3)

Publication Number	Publication Date
DE60319599D1 true DE60319599D1 (de)	2008-04-17
DE60319599T2 DE60319599T2 (de)	2008-06-26
DE60319599T8 DE60319599T8 (de)	2008-10-16

Family

ID=34510740

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60319599T Active DE60319599T8 (de)	2003-10-29	2003-10-29	Verfahren zur differenzierung einer mesenchym-stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit

Country Status (9)

Country	Link
US (1)	US7635591B2 (de)
EP (1)	EP1687413B8 (de)
JP (1)	JP4126060B2 (de)
CN (1)	CN100554409C (de)
AT (1)	ATE388223T1 (de)
AU (1)	AU2003273118B2 (de)
CA (1)	CA2543118C (de)
DE (1)	DE60319599T8 (de)
WO (1)	WO2005040362A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004069172A2 (en)	2003-01-30	2004-08-19	The Government of the United States of America as represented by the Department of Veterans Affairs	Multilineage-inducible cells and uses thereof
EP1620827B1 (de) *	2003-04-24	2010-06-02	Koninklijke Philips Electronics N.V.	Eingriffsfreie links-herzkammervolumenbestimmung
US20090136461A1 (en) *	2007-11-28	2009-05-28	Moon Suk Kim	Neuronal differentiation method of adult stem cells using small molecules
WO2009085216A2 (en)	2007-12-20	2009-07-09	Squicor	Compositions and methods for detecting or elimninating senescent cells to diagnose or treat disease
DK2330889T3 (en)	2008-08-20	2017-01-30	Anthrogenesis Corp	Improved cell composition and process for making the same
US8790638B2 (en) *	2009-02-04	2014-07-29	Stemedica Cell Technologies, Inc.	Compositions of stem cells and stem cell factors and methods for their use and manufacture
CN102439136A (zh)	2009-03-26	2012-05-02	加州大学校董	产生用于疾病修饰的抑制性rna的间充质干细胞
CN101948803B (zh) *	2010-09-13	2012-09-05	中山大学中山眼科中心	人表皮源性间充质干细胞样多能细胞及其制备方法
WO2012156968A2 (en) *	2011-05-19	2012-11-22	Ariel - University Research And Development Company, Ltd.	Use of mesenchymal stem cells for the improvement of affective and cognitive function
KR101446711B1 (ko) *	2011-05-23	2014-10-06	아주대학교산학협력단	간세포 성장인자 유전자 및 염기성 나선-고리-나선 계열의 신경형성 전사인자 유전자가 도입된 성체 줄기세포주 및 그의 용도
US20140065110A1 (en)	2012-08-31	2014-03-06	The Regents Of The University Of California	Genetically modified msc and therapeutic methods
CN103275070A (zh) *	2013-05-10	2013-09-04	郑彪	调节单核细胞增殖的四环化合物及其应用
CN103919806A (zh) *	2014-04-09	2014-07-16	大连医科大学	骨髓间充质干细胞作为治疗正己烷致周围性神经病的药物的应用
CN104004713A (zh) *	2014-05-14	2014-08-27	安沂华	脐带间充质干细胞诱导培养为神经细胞的方法
US20160074438A1 (en) *	2014-09-11	2016-03-17	Taiwan Mitochondrion Applied Technology Co., Ltd	Pharmaceutical compositions for treating degenerative neurological disease with mitocells
WO2019204509A2 (en)	2018-04-18	2019-10-24	Summa Health	Compositions and methods for the treatment of ischemia and cardiomyopathy
WO2022046771A1 (en) *	2020-08-24	2022-03-03	The Johns Hopkins University	Juvenile protective factors to arrest and reverse aging in the enteric nervous system

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US6214334B1 (en) *	1991-10-21	2001-04-10	Trustees Of The University Of Pennsylvania	Compositions and methods for producing and using homogenous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries
EP0792350A1 (de) *	1994-11-14	1997-09-03	Neurospheres Holdings Ltd.	Proliferation regelung von neuralen stammzellen
US5736396A (en)	1995-01-24	1998-04-07	Case Western Reserve University	Lineage-directed induction of human mesenchymal stem cell differentiation
US7015037B1 (en) *	1999-08-05	2006-03-21	Regents Of The University Of Minnesota	Multiponent adult stem cells and methods for isolation
KR100449141B1 (ko) *	2001-04-19	2004-09-21	(주)라이프코드	간엽 간세포를 신경세포로 분화시키는 방법
CN1221660C (zh) *	2001-07-09	2005-10-05	中国人民解放军军事医学科学院野战输血研究所	人骨髓和脐带血间充质干细胞体外分离扩增和向神经细胞定向诱导的方法
CN1745168A (zh) *	2002-12-02	2006-03-08	安增子摩祺株式会社	利用肝细胞生长因子培养神经干细胞的方法

2003
- 2003-10-29 US US10/595,620 patent/US7635591B2/en not_active Expired - Fee Related
- 2003-10-29 JP JP2005509875A patent/JP4126060B2/ja not_active Expired - Fee Related
- 2003-10-29 WO PCT/KR2003/002302 patent/WO2005040362A1/en not_active Ceased
- 2003-10-29 AU AU2003273118A patent/AU2003273118B2/en not_active Ceased
- 2003-10-29 EP EP03754305A patent/EP1687413B8/de not_active Expired - Lifetime
- 2003-10-29 DE DE60319599T patent/DE60319599T8/de active Active
- 2003-10-29 AT AT03754305T patent/ATE388223T1/de active
- 2003-10-29 CA CA002543118A patent/CA2543118C/en not_active Expired - Fee Related
- 2003-10-29 CN CNB2003801106268A patent/CN100554409C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2003273118B2 (en)	2007-05-17
DE60319599T8 (de)	2008-10-16
JP4126060B2 (ja)	2008-07-30
HK1093755A1 (zh)	2007-03-09
WO2005040362A1 (en)	2005-05-06
ATE388223T1 (de)	2008-03-15
DE60319599T2 (de)	2008-06-26
CN100554409C (zh)	2009-10-28
EP1687413A1 (de)	2006-08-09
AU2003273118A1 (en)	2005-05-11
CA2543118A1 (en)	2005-05-06
EP1687413A4 (de)	2006-11-08
JP2007528196A (ja)	2007-10-11
CA2543118C (en)	2009-10-06
EP1687413B1 (de)	2008-03-05
US20070054399A1 (en)	2007-03-08
US7635591B2 (en)	2009-12-22
CN1860224A (zh)	2006-11-08
EP1687413B8 (de)	2008-10-01

Legal Events

Date

Code

Title

Description

2008-10-02

8381

Inventor (new situation)

Inventor name: KIM, HYUN-SOO, SUWON-SI, KYUNGGI-DO, KR

Inventor name: KANG, YOUNG-MO, SUWON-SI, KYUNGGI-DO, KR

Inventor name: LEE, KYUNG-BOCK, SUWON-SI, KYUNGGI-DO, KR

Inventor name: PARK, SANG-KYO, PALDAL-GU, SUWON-SI, KYUNGGI-D, KR

Inventor name: LEE, SANG-KAP, DAEGU-SI, KR

2009-03-26

8364

No opposition during term of opposition

2011-11-22

R082

Change of representative

Ref document number: 1687413

Country of ref document: EP

Representative=s name: PATENT- UND RECHTSANWAELTE KRAUS & WEISERT, 80539

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