ATE388223T1 - Verfahren zur differenzierung einer mesenchym- stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit - Google Patents

Verfahren zur differenzierung einer mesenchym- stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit

Info

Publication number: ATE388223T1
Authority: AT; Austria
Prior art keywords: cell; nerve cell; stem cell; differentiation; pharmaceutical composition
Prior art date: 2003-10-29

Application number

AT03754305T

Other languages

English (en)

Inventor

Hyun-Soo Kim

Young-Mo Kang

Kyung-Bock Lee

Sang-Kyo Park

Sang-Kap Lee

Original Assignee

Fcb Pharmicell Co Ltd

Kim Hyun Soo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-29

Filing date

2003-10-29

Publication date

2008-03-15

2003-10-29 Application filed by Fcb Pharmicell Co Ltd, Kim Hyun Soo filed Critical Fcb Pharmicell Co Ltd

2008-03-15 Application granted granted Critical

2008-03-15 Publication of ATE388223T1 publication Critical patent/ATE388223T1/de

Links

238000000034 method Methods 0.000 title abstract 3
210000002569 neuron Anatomy 0.000 title abstract 3
230000004069 differentiation Effects 0.000 title 1
210000003716 mesoderm Anatomy 0.000 title 1
230000004770 neurodegeneration Effects 0.000 title 1
208000015122 neurodegenerative disease Diseases 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
210000000130 stem cell Anatomy 0.000 title 1
210000002901 mesenchymal stem cell Anatomy 0.000 abstract 4
210000003061 neural cell Anatomy 0.000 abstract 2
230000002062 proliferating effect Effects 0.000 abstract 2
102000009024 Epidermal Growth Factor Human genes 0.000 abstract 1
101800003838 Epidermal growth factor Proteins 0.000 abstract 1
102000003745 Hepatocyte Growth Factor Human genes 0.000 abstract 1
108090000100 Hepatocyte Growth Factor Proteins 0.000 abstract 1
210000001130 astrocyte Anatomy 0.000 abstract 1
238000007796 conventional method Methods 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
229940116977 epidermal growth factor Drugs 0.000 abstract 1
210000005087 mononuclear cell Anatomy 0.000 abstract 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Psychology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)

AT03754305T 2003-10-29 2003-10-29 Verfahren zur differenzierung einer mesenchym- stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit ATE388223T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/KR2003/002302 WO2005040362A1 (en)	2003-10-29	2003-10-29	Method for differentiating mesenchymal stem cell into neural cell and pharmaceutical composition containing the neural cell for neurodegenerative disease

Publications (1)

Publication Number	Publication Date
ATE388223T1 true ATE388223T1 (de)	2008-03-15

Family

ID=34510740

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03754305T ATE388223T1 (de)	2003-10-29	2003-10-29	Verfahren zur differenzierung einer mesenchym- stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit

Country Status (9)

Country	Link
US (1)	US7635591B2 (de)
EP (1)	EP1687413B8 (de)
JP (1)	JP4126060B2 (de)
CN (1)	CN100554409C (de)
AT (1)	ATE388223T1 (de)
AU (1)	AU2003273118B2 (de)
CA (1)	CA2543118C (de)
DE (1)	DE60319599T8 (de)
WO (1)	WO2005040362A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
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WO2004069172A2 (en)	2003-01-30	2004-08-19	The Government of the United States of America as represented by the Department of Veterans Affairs	Multilineage-inducible cells and uses thereof
CN100377165C (zh) *	2003-04-24	2008-03-26	皇家飞利浦电子股份有限公司	无创式左心室的容积测定
US20090136461A1 (en) *	2007-11-28	2009-05-28	Moon Suk Kim	Neuronal differentiation method of adult stem cells using small molecules
WO2009085216A2 (en)	2007-12-20	2009-07-09	Squicor	Compositions and methods for detecting or elimninating senescent cells to diagnose or treat disease
KR20240052847A (ko)	2008-08-20	2024-04-23	셀룰래리티 인코포레이티드	개선된 세포 조성물 및 그의 제조 방법
US8790638B2 (en) *	2009-02-04	2014-07-29	Stemedica Cell Technologies, Inc.	Compositions of stem cells and stem cell factors and methods for their use and manufacture
CA2756670A1 (en)	2009-03-26	2010-09-30	The Regents Of The University Of California	Mesenchymal stem cells producing inhibitory rna for disease modification
CN101948803B (zh) *	2010-09-13	2012-09-05	中山大学中山眼科中心	人表皮源性间充质干细胞样多能细胞及其制备方法
WO2012156968A2 (en) *	2011-05-19	2012-11-22	Ariel - University Research And Development Company, Ltd.	Use of mesenchymal stem cells for the improvement of affective and cognitive function
KR101446711B1 (ko)	2011-05-23	2014-10-06	아주대학교산학협력단	간세포 성장인자 유전자 및 염기성 나선-고리-나선 계열의 신경형성 전사인자 유전자가 도입된 성체 줄기세포주 및 그의 용도
US20140065110A1 (en)	2012-08-31	2014-03-06	The Regents Of The University Of California	Genetically modified msc and therapeutic methods
CN103275070A (zh) *	2013-05-10	2013-09-04	郑彪	调节单核细胞增殖的四环化合物及其应用
CN103919806A (zh) *	2014-04-09	2014-07-16	大连医科大学	骨髓间充质干细胞作为治疗正己烷致周围性神经病的药物的应用
CN104004713A (zh) *	2014-05-14	2014-08-27	安沂华	脐带间充质干细胞诱导培养为神经细胞的方法
TWI707040B (zh) *	2014-09-11	2020-10-11	台灣粒線體應用技術股份有限公司	一種用於治療退化性神經疾病的細胞、含有該細胞的醫藥組合物及其應用
EP3781182A4 (de)	2018-04-18	2021-11-17	Summa Health	Zusammensetzungen und verfahren zur behandlung von ischämie und kardiomyopathie
WO2022046771A1 (en) *	2020-08-24	2022-03-03	The Johns Hopkins University	Juvenile protective factors to arrest and reverse aging in the enteric nervous system

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US6214334B1 (en) *	1991-10-21	2001-04-10	Trustees Of The University Of Pennsylvania	Compositions and methods for producing and using homogenous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries
FI971956L (fi) *	1994-11-14	1997-07-04	Neurospheres Holdings Ltd	Hermosolujen lisääntymisen säännöstely
US5736396A (en) *	1995-01-24	1998-04-07	Case Western Reserve University	Lineage-directed induction of human mesenchymal stem cell differentiation
US7015037B1 (en) *	1999-08-05	2006-03-21	Regents Of The University Of Minnesota	Multiponent adult stem cells and methods for isolation
KR100449141B1 (ko)	2001-04-19	2004-09-21	(주)라이프코드	간엽 간세포를 신경세포로 분화시키는 방법
CN1221660C (zh) *	2001-07-09	2005-10-05	中国人民解放军军事医学科学院野战输血研究所	人骨髓和脐带血间充质干细胞体外分离扩增和向神经细胞定向诱导的方法
CA2507395A1 (en) *	2002-12-02	2004-06-17	Anges Mg, Inc.	Method for culturing neural stem cells using hepatocyte growth factor

2003
- 2003-10-29 AT AT03754305T patent/ATE388223T1/de active
- 2003-10-29 US US10/595,620 patent/US7635591B2/en not_active Expired - Fee Related
- 2003-10-29 EP EP03754305A patent/EP1687413B8/de not_active Expired - Lifetime
- 2003-10-29 DE DE60319599T patent/DE60319599T8/de active Active
- 2003-10-29 CA CA002543118A patent/CA2543118C/en not_active Expired - Fee Related
- 2003-10-29 WO PCT/KR2003/002302 patent/WO2005040362A1/en not_active Ceased
- 2003-10-29 CN CNB2003801106268A patent/CN100554409C/zh not_active Expired - Fee Related
- 2003-10-29 AU AU2003273118A patent/AU2003273118B2/en not_active Ceased
- 2003-10-29 JP JP2005509875A patent/JP4126060B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2543118A1 (en)	2005-05-06
CA2543118C (en)	2009-10-06
JP2007528196A (ja)	2007-10-11
US7635591B2 (en)	2009-12-22
US20070054399A1 (en)	2007-03-08
EP1687413B1 (de)	2008-03-05
AU2003273118B2 (en)	2007-05-17
AU2003273118A1 (en)	2005-05-11
JP4126060B2 (ja)	2008-07-30
CN1860224A (zh)	2006-11-08
DE60319599T8 (de)	2008-10-16
EP1687413A1 (de)	2006-08-09
HK1093755A1 (zh)	2007-03-09
CN100554409C (zh)	2009-10-28
DE60319599T2 (de)	2008-06-26
EP1687413B8 (de)	2008-10-01
DE60319599D1 (de)	2008-04-17
EP1687413A4 (de)	2006-11-08
WO2005040362A1 (en)	2005-05-06

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