DE69015019D1 - Verfahren zur Fermentation und Isolierung von Bernsteinsäure. - Google Patents

Verfahren zur Fermentation und Isolierung von Bernsteinsäure.

Info

Publication number
DE69015019D1
DE69015019D1 DE69015019T DE69015019T DE69015019D1 DE 69015019 D1 DE69015019 D1 DE 69015019D1 DE 69015019 T DE69015019 T DE 69015019T DE 69015019 T DE69015019 T DE 69015019T DE 69015019 D1 DE69015019 D1 DE 69015019D1
Authority
DE
Germany
Prior art keywords
succinic acid
succinate
calcium
treating
highly purified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69015019T
Other languages
English (en)
Other versions
DE69015019T2 (de
Inventor
Rathin Datta
David A Glassner
Mahendra K Jain
John R Vick Roy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Michigan Biotechnology Institute
Original Assignee
Michigan Biotechnology Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michigan Biotechnology Institute filed Critical Michigan Biotechnology Institute
Publication of DE69015019D1 publication Critical patent/DE69015019D1/de
Application granted granted Critical
Publication of DE69015019T2 publication Critical patent/DE69015019T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69015019T 1989-06-28 1990-02-20 Verfahren zur Fermentation und Isolierung von Bernsteinsäure. Expired - Fee Related DE69015019T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/372,721 US5168055A (en) 1986-06-11 1989-06-28 Fermentation and purification process for succinic acid

Publications (2)

Publication Number Publication Date
DE69015019D1 true DE69015019D1 (de) 1995-01-26
DE69015019T2 DE69015019T2 (de) 1995-07-20

Family

ID=23469350

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69015019T Expired - Fee Related DE69015019T2 (de) 1989-06-28 1990-02-20 Verfahren zur Fermentation und Isolierung von Bernsteinsäure.

Country Status (8)

Country Link
US (1) US5168055A (de)
EP (1) EP0405707B1 (de)
JP (1) JPH0330685A (de)
AT (1) ATE115629T1 (de)
AU (1) AU626634B2 (de)
CA (1) CA1338905C (de)
DE (1) DE69015019T2 (de)
NZ (1) NZ231413A (de)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2691457A1 (fr) * 1992-05-20 1993-11-26 Rhone Poulenc Chimie Procédé d'hydrolyse de dicarboxylate d'alkyle.
US5985617A (en) * 1997-02-18 1999-11-16 Liao; James C. Microorganisms and methods for overproduction of DAHP by cloned PPS gene
US5521075A (en) * 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) * 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5573931A (en) * 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
US5869301A (en) * 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5958744A (en) * 1997-08-18 1999-09-28 Applied Carbochemicals Succinic acid production and purification
MY121380A (en) 1998-04-13 2006-01-28 Univ Georgia Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6670505B1 (en) 2000-03-07 2003-12-30 Eastman Chemical Company Process for the recovery of organic acids from aqueous solutions
US6320061B1 (en) 2000-06-05 2001-11-20 Eastman Chemical Company Solvent exchange process
KR20020005200A (ko) * 2000-06-23 2002-01-17 윤덕용 목질계 당화액을 이용한 숙신산의 생산방법
DE10255195A1 (de) * 2002-11-27 2004-06-09 Lipoid Gmbh Micellare wasserlösliche Konzentrate
JP4469568B2 (ja) * 2003-07-09 2010-05-26 三菱化学株式会社 有機酸の製造方法
EP1672077B1 (de) * 2003-08-28 2015-01-21 Mitsubishi Chemical Corporation Verfahren zur herstellung von bernsteinsäure
JP4619291B2 (ja) * 2003-09-17 2011-01-26 三菱化学株式会社 非アミノ有機酸の製造方法
CN100534972C (zh) * 2003-09-30 2009-09-02 味之素株式会社 从发酵液中纯化琥珀酸的方法
JP4301918B2 (ja) * 2003-11-06 2009-07-22 三菱化学株式会社 ポリエステルの製造方法
EP1686183A1 (de) * 2003-11-07 2006-08-02 Mitsubishi Chemical Corporation Verfahren zur herstellung einer organischen säure-ammonium-lösung
KR20050051149A (ko) * 2003-11-27 2005-06-01 한국과학기술원 루멘 박테리아 변이균주 및 이를 이용한 숙신산의 제조방법
JP5023701B2 (ja) 2004-05-20 2012-09-12 味の素株式会社 コハク酸生産菌及びコハク酸の製造方法
JP5572279B2 (ja) * 2004-05-20 2014-08-13 味の素株式会社 コハク酸生産菌及びコハク酸の製造方法
JP4380704B2 (ja) * 2005-04-22 2009-12-09 三菱化学株式会社 バイオマス資源由来ポリエステル及びその製造方法
JP4380653B2 (ja) * 2005-04-22 2009-12-09 三菱化学株式会社 ポリエステル及びその製造方法
JP2009079057A (ja) * 2005-04-22 2009-04-16 Mitsubishi Chemicals Corp ポリエステル及びその製造方法
JP2009077719A (ja) * 2005-04-22 2009-04-16 Mitsubishi Chemicals Corp ポリエステル及びその製造方法
JP2006321996A (ja) * 2005-04-22 2006-11-30 Mitsubishi Chemicals Corp ポリエステルの製造方法
JP2006321994A (ja) * 2005-04-22 2006-11-30 Mitsubishi Chemicals Corp ポリエステルの製造方法
JP4380654B2 (ja) * 2005-04-22 2009-12-09 三菱化学株式会社 ポリエステル及びその製造方法
JP5168072B2 (ja) * 2005-04-26 2013-03-21 三菱化学株式会社 ポリエステルの製造方法
KR100679638B1 (ko) * 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
KR100727054B1 (ko) * 2005-08-19 2007-06-12 한국과학기술원 푸마레이트 하이드라타제 ｃ를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
KR100676160B1 (ko) * 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
AU2006287257A1 (en) * 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
CN101297043B (zh) * 2005-10-18 2013-01-16 味之素株式会社 用于产生琥珀酸的方法
EP1948815A1 (de) * 2005-10-20 2008-07-30 Kris Arvid Bergelund Verfahren zur herstellung von bernsteinsäure
JP5180060B2 (ja) * 2006-02-24 2013-04-10 三菱化学株式会社 有機酸生産菌及び有機酸の製造法
KR100762962B1 (ko) * 2006-05-04 2007-10-04 한국과학기술원 게놈정보 및 인실리코 분석을 이용한 배양배지의 제조방법
JP5052234B2 (ja) * 2006-07-19 2012-10-17 昭和電工株式会社 コハク酸の製造方法
WO2008010373A1 (en) * 2006-07-19 2008-01-24 Showa Denko K.K. A process for producing succinic acid
KR100780324B1 (ko) 2006-07-28 2007-11-29 한국과학기술원 신규 순수 숙신산 생성 변이 미생물 및 이를 이용한 숙신산제조방법
JP5130816B2 (ja) * 2006-08-02 2013-01-30 東レ株式会社 連続発酵によるコハク酸の製造方法
JP4967578B2 (ja) * 2006-10-06 2012-07-04 三菱化学株式会社 バイオマス資源由来ポリエステル製モノフィラメント及びその製造方法
JP5600861B2 (ja) * 2006-10-06 2014-10-08 三菱化学株式会社 バイオマス資源由来ポリエステル製フィルム及びその製造方法
JP5504551B2 (ja) * 2006-10-06 2014-05-28 三菱化学株式会社 バイオマス資源由来ポリエステル製シート及びその製造方法
WO2008091627A2 (en) 2007-01-22 2008-07-31 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
JP5333213B2 (ja) * 2007-05-18 2013-11-06 味の素株式会社 コハク酸およびコハク酸アンモニウム溶液の製造方法
WO2009014289A1 (en) * 2007-07-25 2009-01-29 Korea Advanced Institute Of Science And Technology Method for preparing succinic acid using sucrose as a carbon source
WO2009045637A2 (en) * 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
CN101153294B (zh) * 2007-08-30 2010-11-10 合肥工业大学 琥珀酸的固定化细胞单罐高强度连续发酵工艺
FR2925068B1 (fr) * 2007-12-13 2010-01-08 Roquette Freres Procedes de production d'acide succinique
CN107090424A (zh) 2008-01-22 2017-08-25 基因组股份公司 利用合成气或其它气态碳源和甲醇的方法和有机体
EP3450550A1 (de) 2008-03-05 2019-03-06 Genomatica, Inc. Primäre, alkohole produzierende organismen
PL2265709T3 (pl) 2008-03-27 2018-05-30 Genomatica, Inc. Mikroorganizmy do produkcji kwasu adypinowego i innych związków
WO2009135074A2 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
WO2009155382A1 (en) * 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
ES2655739T3 (es) 2008-12-02 2018-02-21 Purac Biochem Bv Procedimiento de preparación de una sal de succinato monovalente
CA2746952A1 (en) 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
BRPI1013505A2 (pt) 2009-04-30 2018-02-14 Genomatica Inc organismos para a produção de isopropanol, n-butanol, e isobutanol
EP3865569B1 (de) 2009-04-30 2023-10-04 Genomatica, Inc. Organismen zur herstellung von 1,3-butandiol
WO2010129936A1 (en) 2009-05-07 2010-11-11 Genomatica, Inc. Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
KR20120036851A (ko) 2009-05-15 2012-04-18 게노마티카 인코포레이티드 사이클로헥사논의 제조를 위한 유기체
WO2010144746A2 (en) 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
DK2462221T3 (en) 2009-08-05 2017-05-22 Genomatica Inc SEMISYNTHETIC TEREPHTHALIC ACID BY MICRO-ORGANISMS PRODUCING MUCONIC ACID
US8715971B2 (en) 2009-09-09 2014-05-06 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol and 1,4-butanediol
WO2011043443A1 (ja) * 2009-10-07 2011-04-14 三菱化学株式会社 脂肪族ジカルボン酸の製造方法
AU2010306785B2 (en) 2009-10-13 2016-01-14 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
US20110097767A1 (en) 2009-10-23 2011-04-28 Priti Pharkya Microorganisms for the production of aniline
WO2011064151A1 (en) 2009-11-24 2011-06-03 Dsm Ip Assets B.V. Process for the crystallization of succinic acid
WO2011069008A1 (en) 2009-12-02 2011-06-09 Board Of Trustees Michigan State University Carboxylic acid recovery and methods related thereto
CN102753698A (zh) 2009-12-10 2012-10-24 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
EP2519491A4 (de) 2009-12-31 2014-10-08 Groupe Novasep Sas Reinigung von bernsteinsäure aus der fermentierung von sprossen mit ammoniumsuccinat
CN102834508A (zh) 2010-01-29 2012-12-19 基因组股份公司 用于生物合成对甲苯甲酸和对苯二甲酸的微生物和方法
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
WO2011115136A1 (ja) 2010-03-16 2011-09-22 三菱化学株式会社 コハク酸の製造方法
EP2371802A1 (de) 2010-03-30 2011-10-05 DSM IP Assets B.V. Verfahren zur Kristallisierung von Bernsteinsäure
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
KR20190006103A (ko) 2010-05-05 2019-01-16 게노마티카 인코포레이티드 부타디엔을 생합성하기 위한 미생물 및 방법
DE102010025167A1 (de) 2010-06-25 2011-12-29 Uhde Gmbh Verfahren zur Abtrennung, Gewinnung und Reinigung von Bernsteinsäure
WO2012018624A2 (en) 2010-07-26 2012-02-09 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
US20130130339A1 (en) 2010-07-31 2013-05-23 Myriant Corporation Fermentation process for the production of organic acids
JP6368488B2 (ja) * 2010-12-29 2018-08-01 シージェイ チェイルジェダン コーポレーション Ｌ−メチオニン及び関連産物の生産方法
JP6032198B2 (ja) 2011-03-18 2016-11-24 三菱化学株式会社 ポリマーの製造方法、有機酸の製造方法及び有機酸生産菌
WO2013028783A1 (en) * 2011-08-22 2013-02-28 Suganit Systems, Inc. Production of bio-butanol and related products
DE102011120632A1 (de) 2011-12-09 2013-06-13 Thyssenkrupp Uhde Gmbh Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen
FR2987678B1 (fr) 2012-03-02 2016-04-15 Roquette Freres Methode de mesure de la stabilite thermique d'un acide succinique cristallin destine a la fabrication de polymeres
CN102807486B (zh) * 2012-08-16 2014-09-17 旭阳化学技术研究院有限公司 一种制备丁二酸的方法
EP2745905A1 (de) 2012-12-21 2014-06-25 ThyssenKrupp Uhde GmbH Verfahren zur Reinigung von Carboxylsäuren durch subkritische oder superkritische Chromatography
DE102013000027A1 (de) 2013-01-03 2014-07-03 Thyssenkrupp Industrial Solutions Ag Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen
WO2014108163A2 (de) 2013-01-11 2014-07-17 Thyssenkrupp Uhde Gmbh Verfahren zur herstellung von dicarbonsäuren
JP2015080744A (ja) * 2013-10-22 2015-04-27 三菱化学株式会社 脂肪族ジカルボン酸含有液の製造方法
TW201538477A (zh) 2013-12-06 2015-10-16 Myriant Corp 製備丁二酸酯之方法
JP2014139325A (ja) * 2014-04-17 2014-07-31 Mitsubishi Chemicals Corp バイオマス資源由来ポリエステル製フィルム
JP2014133899A (ja) * 2014-04-23 2014-07-24 Mitsubishi Chemicals Corp バイオマス資源由来ポリエステル製延伸フィルム
FR3028864B1 (fr) 2014-11-26 2018-05-18 Roquette Freres Procede de recuperation de cristaux d'acide succinique avec mise en œuvre de tensioactifs au cours de la cristallisation, cristaux obtenus et leurs utilisations
CN104876817B (zh) * 2015-04-24 2017-07-28 镇江博睿兴邦生物科技有限公司 一种使用丁二酸发酵液提取丁二酸的方法
WO2018089971A1 (en) * 2016-11-14 2018-05-17 Lygos, Inc. Process for purification of malonic acid from fermentation broth
PL236607B1 (pl) * 2017-11-09 2021-02-08 Politechnika Poznanska Sposób wydzielania kwasu bursztynowego z brzeczki fermentacyjnej
JP7483305B2 (ja) * 2021-01-15 2024-05-15 エルジー・ケム・リミテッド ３－ヒドロキシプロピオネートの結晶および３－ヒドロキシプロピオン酸の回収工程
CN120796113A (zh) * 2025-07-04 2025-10-17 中国食品发酵工业研究院有限公司 一株高产丁二酸的大肠杆菌及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US588545A (en) * 1897-08-17 Chusetts
US4110175A (en) * 1976-06-30 1978-08-29 Aqua-Chem, Inc. Electrodialysis method
US4564594A (en) * 1983-06-30 1986-01-14 E. I. Du Pont De Nemours And Company Fermentation process for production of carboxylic acids
FR2555200B1 (fr) * 1983-11-23 1986-07-25 Centre Nat Rech Scient Procede de preparation d'acide lactique par fermentation de lactoserum et installation pour la mise en oeuvre en continu de ce procede
US4766161A (en) * 1986-06-05 1988-08-23 Allied Corporation Bipolar membranes and methods of making same
ES2036188T3 (es) * 1986-06-11 1993-05-16 Michigan Biotechnology Institute Un procedimiento para la produccion de acido succinico por fermentacion anaerobia.
US4678553A (en) * 1986-07-11 1987-07-07 Ionics, Incorporated Renaturing reversibly denatured polypeptides and proteins by electrodialysis of solutions thereof in denaturants

Also Published As

Publication number Publication date
EP0405707B1 (de) 1994-12-14
ATE115629T1 (de) 1994-12-15
AU626634B2 (en) 1992-08-06
CA1338905C (en) 1997-02-11
EP0405707A1 (de) 1991-01-02
AU4938690A (en) 1991-01-03
DE69015019T2 (de) 1995-07-20
JPH0330685A (ja) 1991-02-08
US5168055A (en) 1992-12-01
NZ231413A (en) 1992-03-26

Similar Documents

Publication Publication Date Title
ATE115629T1 (de) Verfahren zur fermentation und isolierung von bernsteinsäure.
DE69015233D1 (de) Verfahren zur Herstellung und Reinigung von Bernsteinsäure.
JPS6427485A (en) Production of l-2-amino-4-(hydroxymethylphosphinyl)-butyric acid
DE3570866D1 (en) Process for the isolation of citric acid
ATE132904T1 (de) Verfahren zur herstellung von trehalulose und isomaltulose
PH25423A (en) Method of treating bacterial infections using benzoxazine carboxylic acid
ATE126829T1 (de) Verfahren zur herstellung von salzen des l- ornithins.
DE69213876D1 (de) Verfahren zum Abtrennen von Lysine in Form von einer wässerigen Lösung und Verwendung dieser Lösung in der Tierernährung
DE3684434D1 (de) Verfahren zur herstellung von 2-keto-d-glukarsaeure.
ATE210729T1 (de) Verfahren zur herstellung von trans-4-hydroxy-l- prolin
DE3581218D1 (de) Verfahren zur herstellung von 6-hydroxynikotinsaeure.
FI853910A0 (fi) Foerbaettrat foerfarande foer framstaellning av a-21978c-derivat.
ATE129699T1 (de) Verfahren zur herstellung gereinigter alkansulfonsäuren.
FR2635334B1 (fr) Procede de production d'acide lactique par fermentation
ATE167871T1 (de) Verfahren zur herstellung von vancomycin
ATE289355T1 (de) Verfahren zur herstellung von gluconsäure und durch dieses hergestellte gluconsäure
DE59603480D1 (de) Verfahren zur Herstellung einer organischen Säure
DE59209053D1 (de) Verfahren zur Herstellung aktivierter Sialinsäuren
ATE361280T1 (de) Verfahren zur herstellung von hochreinem nicotinamid
US3058888A (en) Process for producing alpha-isoleucine
ATE124954T1 (de) Verfahren zur herstellung von tauroursodesoxycholsäure dihydrat.
ATE15052T1 (de) Verfahren zur herstellung von alpha-aspartylphenylalamin methylester.
JPS55108294A (en) Production of purine nucleoside through fermentation process
ATE144554T1 (de) Mikrobiologisches verfahren zur herstellung von 6-hydroxypyrazincarbonsäure
DE1770167C3 (de) Verfahren zur fermentativen Herstellung von Orotidylsäure

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee