ATE210729T1 - Verfahren zur herstellung von trans-4-hydroxy-l- prolin - Google Patents

Verfahren zur herstellung von trans-4-hydroxy-l- prolin

Info

Publication number: ATE210729T1
Authority: AT; Austria
Prior art keywords: proline; hydroxy; trans; useful; aqueous medium
Prior art date: 1993-09-07

Application number

AT94113955T

Other languages

English (en)

Inventor

Akio Ozaki

Hideo Mori

Takeshi Shibasaki

Katsuhiko Ando

Shigeru Chiba

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-07

Filing date

1994-09-06

Publication date

2001-12-15

1994-09-06 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE210729T1 publication Critical patent/ATE210729T1/de

Links

PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 title abstract 5
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 title abstract 5
PMMYEEVYMWASQN-IMJSIDKUSA-N trans-4-Hydroxy-L-proline Natural products O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 3
KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 2
229930182821 L-proline Natural products 0.000 abstract 2
239000012736 aqueous medium Substances 0.000 abstract 2
229960002429 proline Drugs 0.000 abstract 2
241000187643 Amycolatopsis Species 0.000 abstract 1
241001495437 Dactylosporangium Species 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
235000013305 food Nutrition 0.000 abstract 1
230000033444 hydroxylation Effects 0.000 abstract 1
238000005805 hydroxylation reaction Methods 0.000 abstract 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 1
229910052742 iron Inorganic materials 0.000 abstract 1
-1 iron ion Chemical class 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000002994 raw material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
- C12Y114/11002—Procollagen-proline dioxygenase (1.14.11.2), i.e. proline-hydroxylase

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT94113955T 1993-09-07 1994-09-06 Verfahren zur herstellung von trans-4-hydroxy-l- prolin ATE210729T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP22194093		1993-09-07
JP33256193		1993-12-27

Publications (1)

Publication Number	Publication Date
ATE210729T1 true ATE210729T1 (de)	2001-12-15

Family

ID=26524587

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94113955T ATE210729T1 (de)	1993-09-07	1994-09-06	Verfahren zur herstellung von trans-4-hydroxy-l- prolin

Country Status (6)

Country	Link
EP (1)	EP0641862B1 (de)
KR (1)	KR100356926B1 (de)
CN (2)	CN1085253C (de)
AT (1)	ATE210729T1 (de)
DE (1)	DE69429396T2 (de)
ES (1)	ES2164675T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2176441T3 (es) *	1995-03-07	2002-12-01	Kyowa Hakko Kogyo Kk	Meetodo para producir trnas-4-hiddroxi-l-prolina.
JP3739143B2 (ja) *	1996-09-03	2006-01-25	協和醗酵工業株式会社	トランス−４−ヒドロキシ−ｌ−プロリンの製造法
CA2234412C (en) *	1997-06-09	2008-09-02	Kyowa Hakko Kogyo Co., Ltd.	Method for producing optically active compound
US9790527B2 (en)	2012-05-08	2017-10-17	Codexis, Inc.	Engineered proline hydroxylase polypeptides
DK2847214T3 (en)	2012-05-11	2018-03-12	Codexis Inc	CONSTRUCTED IMINE REDUCTIONS AND PROCEDURES FOR THE REDUCED AMINING OF KETON AND AMINE COMPOUNDS
US9822346B2 (en)	2013-11-13	2017-11-21	Codexis, Inc.	Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
JP6719463B2 (ja)	2014-11-25	2020-07-15	コデクシス，インコーポレイテッド	ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法
CN105483069B (zh) *	2015-12-09	2019-01-18	浙江绿创生物科技有限公司	一株生产反式-4-羟基-l-脯氨酸的重组菌株及其构建与应用
SG11201809575TA (en)	2016-06-09	2018-11-29	Codexis Inc	Biocatalysts and methods for hydroxylation of chemical compounds
WO2017218325A1 (en)	2016-06-15	2017-12-21	Codexis, Inc.	Engineered beta-glucosidases and glucosylation methods
EP3515926B1 (de)	2016-08-26	2023-10-25	Codexis, Inc.	Manipulierte iminreduktasen und verfahren zur reduktiven aminierung von keton- und aminverbindungen
US12215368B2 (en)	2019-05-01	2025-02-04	Codexis, Inc.	Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN114096662B (zh)	2019-05-01	2025-04-15	科德克希思公司	工程化葡萄糖脱氢酶和用于酮和胺化合物的还原胺化的方法
US12344865B2 (en)	2019-11-26	2025-07-01	Codexis, Inc.	Biocatalysts and methods for hydroxylation of chemical compounds
US12565641B2 (en)	2021-10-15	2026-03-03	Codexis, Inc.	Engineered terminal deoxynucleotidyl transferase variants
CN116855551A (zh) *	2023-08-22	2023-10-10	石家庄市冀荣药业有限公司	一种生物法转化生产l-羟脯氨酸的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0190350A1 (de) *	1984-07-31	1986-08-13	NAGAI, Yoshiki	Verfahren zur herstellung menschlicher hydroxylase
WO1993004181A1 (fr) *	1991-08-26	1993-03-04	Kyowa Hakko Kogyo Co., Ltd.	Procede pour la production de 4-hydroxy-l-proline
JPH05236980A (ja) *	1991-12-17	1993-09-17	Sankyo Co Ltd	トランス−４−ヒドロキシ−ｌ−プロリンの製造法

1994
- 1994-09-01 KR KR1019940022036A patent/KR100356926B1/ko not_active Expired - Lifetime
- 1994-09-05 CN CN94115662A patent/CN1085253C/zh not_active Expired - Lifetime
- 1994-09-06 DE DE69429396T patent/DE69429396T2/de not_active Expired - Lifetime
- 1994-09-06 EP EP94113955A patent/EP0641862B1/de not_active Expired - Lifetime
- 1994-09-06 AT AT94113955T patent/ATE210729T1/de not_active IP Right Cessation
- 1994-09-06 ES ES94113955T patent/ES2164675T3/es not_active Expired - Lifetime
2001
- 2001-11-19 CN CNB011374608A patent/CN1171992C/zh not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0641862B1 (de)	2001-12-12
KR100356926B1 (ko)	2003-01-10
DE69429396D1 (de)	2002-01-24
EP0641862A2 (de)	1995-03-08
ES2164675T3 (es)	2002-03-01
CN1392257A (zh)	2003-01-22
CN1106457A (zh)	1995-08-09
KR950008692A (ko)	1995-04-19
EP0641862A3 (de)	1997-06-04
DE69429396T2 (de)	2002-06-13
HK1051218A1 (en)	2003-07-25
CN1171992C (zh)	2004-10-20
CN1085253C (zh)	2002-05-22

Legal Events

Date	Code	Title	Description
2002-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE210729T1 (de)	2001-12-15	Verfahren zur herstellung von trans-4-hydroxy-l- prolin
ATE287959T1 (de)	2005-02-15	Verfahren zur herstellung von trans-4-hydroxy-l- prolin
EP0625571A3 (de)	1995-02-15	Neue Mikroorganismen, deren Verwendung und Verfahren zur Herstellung von L-Alpha-Aminosäuren.
ATE106451T1 (de)	1994-06-15	Fermentationsverfahren zur herstellung von 2-keto-l-gulonsäure.
ATE486949T1 (de)	2010-11-15	Verfahren zur herstellung von n- acetylneuraminsäure
DE68906904D1 (de)	1993-07-15	Verfahren zur herstellung von optisch aktiven 2-arylalkansaeuren.
ATE196166T1 (de)	2000-09-15	Enzymatisches hydroxylierungsverfahren zur herstellung von hmg-coa-reduktaseinhibitoren und intermediate hiervon
ATE59859T1 (de)	1991-01-15	Verfahren zur herstellung von 6hydroxynikotins\|ure.
GR3021357T3 (en)	1997-01-31	Production of vanillin by bioconversion of benzenic precursors
CA2253977A1 (en)	1997-12-04	Process for the preparation of amino alcohols and derivatives thereof
ATE164628T1 (de)	1998-04-15	L-proline-3-hydroxylase und verfahren zur herstellung von cis-3-hydroxy-l-prolin
CA2131776A1 (en)	1995-10-06	Process for producing cis-3-hydroxy-l-proline
CA2131775A1 (en)	1995-06-28	Process for producing trans-4-hydroxy-l-proline
EP0589285A3 (de)	1995-02-15	Verfahren zur Herstellung von Biotin.
ES521943A0 (es)	1984-08-16	Un procedimiento de produccion de glucosa deshidrogenasa.
DE58907274D1 (de)	1994-04-28	VERFAHREN ZUR STEIGERUNG VON ENZYM-AKTIVITÄTEN UND DER SYNTHESELEISTUNG VON MIKROORGANISMEN UND HöHEREN PFLANZEN.
DE3885438D1 (de)	1993-12-09	Verfahren zur Herstellung von mikrobieller Cellulose.
Ozaki et al.	2001	Process for producing trans-4-hydroxy-l-proline
ATE144554T1 (de)	1996-11-15	Mikrobiologisches verfahren zur herstellung von 6-hydroxypyrazincarbonsäure
ATE95568T1 (de)	1993-10-15	Mikrobiologisches verfahren zur herstellung von uk-61.689 und mikroorganismen zur verwendung darin.
DE3853143D1 (de)	1995-03-30	Verfahren zur Herstellung von AccI-Restriktionsendonuklease und -methylase.
DE59208669D1 (de)	1997-08-14	Verfahren zur Herstellung von MA
DE68908253D1 (de)	1993-09-16	Verfahren zur herstellung von itaconsaeure.
AU2564888A (en)	1989-05-18	Novel urease and method of producing the same
ATE144285T1 (de)	1996-11-15	Mikrobiologisches verfahren zur herstellung von 5-hydroxy-2-pyrazincarbonsäure