DE69822859T2 - Krytallinischer fungizider polymorph - Google Patents

Krytallinischer fungizider polymorph Download PDF

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Publication number
DE69822859T2
DE69822859T2 DE69822859T DE69822859T DE69822859T2 DE 69822859 T2 DE69822859 T2 DE 69822859T2 DE 69822859 T DE69822859 T DE 69822859T DE 69822859 T DE69822859 T DE 69822859T DE 69822859 T2 DE69822859 T2 DE 69822859T2
Authority
DE
Germany
Prior art keywords
phenyl
crystalline
polymorphic form
crystalline polymorphic
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69822859T
Other languages
German (de)
English (en)
Other versions
DE69822859D1 (de
Inventor
R. David ANDREWS
William Leong
R. Anantha SUDHAKAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69822859D1 publication Critical patent/DE69822859D1/de
Application granted granted Critical
Publication of DE69822859T2 publication Critical patent/DE69822859T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69822859T 1997-10-07 1998-10-05 Krytallinischer fungizider polymorph Expired - Lifetime DE69822859T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94618397A 1997-10-07 1997-10-07
US946183 1997-10-07
PCT/US1998/020476 WO1999018097A1 (en) 1997-10-07 1998-10-05 Crystalline antifungal polymorph

Publications (2)

Publication Number Publication Date
DE69822859D1 DE69822859D1 (de) 2004-05-06
DE69822859T2 true DE69822859T2 (de) 2005-01-27

Family

ID=25484068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69822859T Expired - Lifetime DE69822859T2 (de) 1997-10-07 1998-10-05 Krytallinischer fungizider polymorph

Country Status (30)

Country Link
EP (1) EP1021439B1 (2)
JP (4) JP2001519346A (2)
KR (1) KR100626109B1 (2)
CN (1) CN1125067C (2)
AR (1) AR015947A1 (2)
AT (1) ATE263163T1 (2)
AU (1) AU759982B2 (2)
BR (1) BR9812866A (2)
CA (1) CA2305803C (2)
CO (1) CO4970829A1 (2)
CZ (1) CZ299835B6 (2)
DE (1) DE69822859T2 (2)
DK (1) DK1021439T3 (2)
ES (1) ES2217594T3 (2)
HU (1) HU225233B1 (2)
ID (1) ID29290A (2)
IL (1) IL135331A (2)
IN (1) IN1998CH02232A (2)
MX (1) MX225999B (2)
MY (1) MY130126A (2)
NO (1) NO318827B1 (2)
NZ (1) NZ503662A (2)
PE (1) PE120499A1 (2)
PH (1) PH11998002606B1 (2)
PL (1) PL189317B1 (2)
PT (1) PT1021439E (2)
SK (1) SK285190B6 (2)
TW (1) TW589310B (2)
WO (1) WO1999018097A1 (2)
ZA (1) ZA989063B (2)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2130540A1 (en) * 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
EP2451805A1 (en) 2009-07-09 2012-05-16 Sandoz AG A crystalline form of posaconazole
EP2571847B1 (en) 2010-05-19 2016-09-21 Sandoz AG Process for the preparation of chiral hydrazides
US9040539B2 (en) 2010-05-19 2015-05-26 Sandoz Ag Process for the preparation of chiral triazolones
CN102892762B (zh) 2010-05-19 2016-04-20 桑多斯股份公司 制备泊沙康唑中间体
RU2585683C2 (ru) 2010-05-19 2016-06-10 Сандоз Аг Очистка позаконазола и промежуточных продуктов для синтеза позаконазола
CN103635465A (zh) 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
EP2758385B1 (en) * 2011-09-19 2018-03-28 MSN Laboratories Limited Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof
WO2015011224A1 (en) * 2013-07-25 2015-01-29 Sandoz Ag Improved process for the preparation of crystalline form iv of posaconazole
ITMI20132115A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132117A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132114A1 (it) 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132118A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
CN104387374A (zh) * 2014-10-21 2015-03-04 江苏恒盛药业有限公司 泊沙康唑晶型i的制备工艺
UA119794C2 (uk) 2014-10-21 2019-08-12 Аріад Фармасьютикалз, Інк. Кристалічна форма 5-хлор-n4-[2-(диметилфосфорил)феніл]-n2-{2-метокси-4-[4-(4-метилпіперазин-1-іл)піперидин-1-іл]}піримідин-2,4-діаміну
PL3331501T3 (pl) 2015-08-08 2020-03-31 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Preparat o zwiększonej odporności na warunki przewodu pokarmowego zawierający pozakonazol
EA039213B1 (ru) 2015-12-24 2021-12-17 Такеда Фармасьютикал Компани Лимитед Сокристалл, способ его получения и лекарственное средство, содержащее сокристалл
EP4424308A3 (en) 2016-02-26 2024-12-04 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
TR201722493A2 (tr) 2017-12-28 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon
WO2022034232A1 (en) 2020-08-13 2022-02-17 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant high-strength formulation containing posaconazole
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole
EP4181883B1 (en) 2021-11-25 2025-11-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
IL112081A (en) * 1993-12-21 2001-08-26 Schering Plough Corp Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them
ES2141329T3 (es) * 1994-01-24 2000-03-16 Janssen Pharmaceutica Nv Antifungicos azolicos solubles en agua.
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
IL118464A (en) * 1995-06-02 2000-08-13 Schering Corp (2R-cis)-4-¬4-¬4-¬4¬¬-5-(2',4 dihalophenyl)-tetrahydro-5-(1-H-1,2,4,triazol-1-yl-methyl)furan-3-yl(methoxy¾phenyl¾-1-piperazinyl¬phenyl2,4,dihydro2¬(5)-1-ethyl-2-(5)hydroxy propyl¾-3H-1,2,4-triazol-3-one and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
PE120499A1 (es) 1999-12-04
CZ20001264A3 (cs) 2000-08-16
IN1998CH02232A (2) 2005-03-04
HUP0004899A2 (hu) 2002-02-28
PL189317B1 (pl) 2005-07-29
PL339659A1 (en) 2001-01-02
JP2012153729A (ja) 2012-08-16
NO20001779D0 (no) 2000-04-06
MX225999B (es) 2005-02-02
CO4970829A1 (es) 2000-11-07
HU225233B1 (en) 2006-08-28
JP2001519346A (ja) 2001-10-23
CA2305803C (en) 2009-12-22
IL135331A0 (en) 2001-05-20
JP2012153730A (ja) 2012-08-16
SK285190B6 (sk) 2006-08-03
EP1021439A1 (en) 2000-07-26
CN1125067C (zh) 2003-10-22
TW589310B (en) 2004-06-01
PH11998002606B1 (en) 2006-08-10
ZA989063B (en) 1999-04-06
ID29290A (id) 2001-08-16
KR100626109B1 (ko) 2006-09-20
DK1021439T3 (da) 2004-05-10
CN1281449A (zh) 2001-01-24
AR015947A1 (es) 2001-05-30
AU759982B2 (en) 2003-05-01
ES2217594T3 (es) 2004-11-01
EP1021439B1 (en) 2004-03-31
NO318827B1 (no) 2005-05-09
CZ299835B6 (cs) 2008-12-10
DE69822859D1 (de) 2004-05-06
AU9780398A (en) 1999-04-27
NO20001779L (no) 2000-06-06
NZ503662A (en) 2002-10-25
HK1029588A1 (en) 2001-04-06
MY130126A (en) 2007-06-29
BR9812866A (pt) 2000-08-08
JP2008106075A (ja) 2008-05-08
CA2305803A1 (en) 1999-04-15
IL135331A (en) 2005-08-31
ATE263163T1 (de) 2004-04-15
KR20010030959A (ko) 2001-04-16
PT1021439E (pt) 2004-07-30
MXPA00003404A (es) 2000-11-01
HUP0004899A3 (en) 2002-03-28
SK5122000A3 (en) 2000-09-12
WO1999018097A1 (en) 1999-04-15

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