DK0387771T3 - Benzopyranderivater - Google Patents

Benzopyranderivater

Info

Publication number: DK0387771T3
Authority: DK; Denmark
Prior art keywords: hydrogen; alkyl; formula; bond; group
Prior art date: 1989-03-13

Application number

DK90104680.5T

Other languages

English (en)

Inventor

Shuichi Ohuchida

Masaaki Toda

Tsumoru Miyamoto

Original Assignee

Ono Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-13

Filing date

1990-03-12

Publication date

1995-07-31

1990-03-12 Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co

1995-07-31 Application granted granted Critical

1995-07-31 Publication of DK0387771T3 publication Critical patent/DK0387771T3/da

Links

KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 15
239000001257 hydrogen Substances 0.000 abstract 15
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 12
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 8
150000002431 hydrogen Chemical class 0.000 abstract 7
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 5
125000002947 alkylene group Chemical group 0.000 abstract 4
229910052799 carbon Inorganic materials 0.000 abstract 4
125000004450 alkenylene group Chemical group 0.000 abstract 3
125000004419 alkynylene group Chemical group 0.000 abstract 3
125000002837 carbocyclic group Chemical group 0.000 abstract 3
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000000204 (C2-C4) acyl group Chemical group 0.000 abstract 1
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000032683 aging Effects 0.000 abstract 1
230000003064 anti-oxidating effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001562 benzopyrans Chemical class 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004953 trihalomethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Saccharide Compounds (AREA)

DK90104680.5T 1989-03-13 1990-03-12 Benzopyranderivater DK0387771T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP6031789		1989-03-13
JP28280589		1989-10-30

Publications (1)

Publication Number	Publication Date
DK0387771T3 true DK0387771T3 (da)	1995-07-31

Family

ID=26401387

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90104680.5T DK0387771T3 (da)	1989-03-13	1990-03-12	Benzopyranderivater

Country Status (10)

Country	Link
US (1)	US5055598A (da)
EP (1)	EP0387771B1 (da)
JP (1)	JP2955717B2 (da)
KR (1)	KR0156538B1 (da)
AT (1)	ATE123491T1 (da)
CA (1)	CA2011899A1 (da)
DE (1)	DE69019849T2 (da)
DK (1)	DK0387771T3 (da)
ES (1)	ES2075079T3 (da)
GR (1)	GR3016985T3 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2676056B1 (fr) *	1991-05-03	1993-07-16	Adir	Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP0550292A1 (en) *	1992-01-02	1993-07-07	Merrell Dow Pharmaceuticals Inc.	Tissue protective tocopherol analogs
SI9300097B (en) *	1992-02-27	2001-12-31	Janssen Pharmaceutica Nv	(benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
US5510373A (en) *	1992-04-06	1996-04-23	Merrell Pharmaceuticals Inc.	Cardioprotective agents
US5721233A (en) *	1992-04-06	1998-02-24	Merrell Pharmaceuticals Inc.	Derivatives of 2,3-dihydro benzofuranols
US5545660A (en) *	1992-04-07	1996-08-13	Merrell Pharmaceuticals Inc.	Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
US5703115A (en) *	1993-02-19	1997-12-30	Janssen Pharmaceutica, N.V.	(benzodioxan, benzofuran or benzopyran) alkylamino! alkyl substituted guanidines
US5811453A (en)	1994-12-23	1998-09-22	Alcon Laboratories, Inc.	Viscoelastic compositions and methods of use
US5925673A (en) *	1994-12-23	1999-07-20	Alcon Laboratories, Inc.	Benzofurans and benzopyrans as cytoprotective agents
US5607966A (en) *	1994-12-23	1997-03-04	Alcon Laboratories, Inc.	Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs
US5643943A (en) *	1994-12-23	1997-07-01	Alcon Laboratories, Inc.	Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
US5750564A (en) *	1995-09-12	1998-05-12	Hellberg; Mark	Anti-oxidant esters of non-steroidal anti-inflammatory agents
US6197806B1 (en)	1995-12-20	2001-03-06	Nippon Zoki Pharmaceutical Co., Ltd.	Eliminating agent for activated oxygen and free radicals
US5747528A (en) *	1996-02-21	1998-05-05	Warner-Lambert Company	Chroman derivatives as anti-oxidants
IT1289494B1 (it) *	1996-12-20	1998-10-15	Biomedica Foscana Ind Chimico	Acidi 5-idrossi- e 5-acilossi-2,3-diidro-4,6,7-trimetil-2- benzofuranaceti e loro esteri per il trattamento e la prevenzione
CA2319131A1 (en)	1998-01-26	1999-07-29	Walter H. Moos	Mitochondria protecting agents for treating mitochondria associated diseases
CA2339879C (en)	1998-08-24	2011-11-15	Toshio Miyata	Carbonyl-stress improving agent and peritoneal dialysate
AU754989B2 (en)	1998-11-16	2002-11-28	Nippon Zoki Pharmaceutical Co., Ltd.	A therapeutic agent for intractable vasculitis
US6503949B1 (en)	1999-05-17	2003-01-07	Noro Nordisk A/S	Glucagon antagonists/inverse agonists
JP4711523B2 (ja)	2001-02-13	2011-06-29	日本臓器製薬株式会社	低アルブミン血症改善剤
FR2822463B1 (fr) *	2001-03-21	2004-07-30	Lipha	Derives bicycliques de guanidines et leurs applications en therapeutique
ITTO20030140U1 (it) *	2003-09-16	2005-03-17	Interfila Srl	Matita cosmetica
WO2005033092A1 (en)	2003-09-19	2005-04-14	Galileo Pharmaceuticals, Inc.	Chroman derivatives
US7384558B2 (en) *	2004-07-26	2008-06-10	Baxter International Inc.	Compositions capable of inhibiting reactive oxygen and carbonyl species
KR102634384B1 (ko) *	2023-03-28	2024-02-06	자경케미칼 주식회사	헤테로사이클릭 아미노산의 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1286299C (en) *	1985-05-13	1991-07-16	Johji Yamahara	3,4-dihydrobenzopyran derivatives and medicinal uses thereof
JPH0631207B2 (ja) *	1985-05-13	1994-04-27	株式会社クラレ	３，４−ジヒドロベンゾピラン誘導体類及びこれを有効成分とする抗消化性潰瘍剤

1990
- 1990-03-09 CA CA002011899A patent/CA2011899A1/en not_active Abandoned
- 1990-03-12 DK DK90104680.5T patent/DK0387771T3/da active
- 1990-03-12 ES ES90104680T patent/ES2075079T3/es not_active Expired - Lifetime
- 1990-03-12 AT AT90104680T patent/ATE123491T1/de not_active IP Right Cessation
- 1990-03-12 DE DE69019849T patent/DE69019849T2/de not_active Expired - Fee Related
- 1990-03-12 EP EP90104680A patent/EP0387771B1/en not_active Expired - Lifetime
- 1990-03-12 US US07/491,876 patent/US5055598A/en not_active Expired - Fee Related
- 1990-03-13 KR KR1019900003301A patent/KR0156538B1/ko not_active Expired - Fee Related
- 1990-03-13 JP JP2059845A patent/JP2955717B2/ja not_active Expired - Fee Related
1995
- 1995-08-02 GR GR950402101T patent/GR3016985T3/el unknown

Also Published As

Publication number	Publication date
EP0387771B1 (en)	1995-06-07
KR900014350A (ko)	1990-10-23
JP2955717B2 (ja)	1999-10-04
ATE123491T1 (de)	1995-06-15
EP0387771A3 (en)	1990-12-27
DE69019849T2 (de)	1995-11-16
EP0387771A2 (en)	1990-09-19
KR0156538B1 (ko)	1998-11-16
CA2011899A1 (en)	1990-09-13
GR3016985T3 (en)	1995-11-30
DE69019849D1 (de)	1995-07-13
ES2075079T3 (es)	1995-10-01
US5055598A (en)	1991-10-08
JPH03204874A (ja)	1991-09-06

Publication	Publication Date	Title
DE69019849D1 (de)	1995-07-13	Benzopyran-Derivate.
FR2372804A1 (fr)	1978-06-30	Derives d'amino-acides, en tant qu'agents anti-hypertension
NL960019I2 (nl)	1997-06-02	Morfolino-ethylester van mycofenolzuur en derivaten ervan, de bereiding ervan en hun toepassing in farmaceutische samenstellingen.
DK0430045T3 (da)	1995-07-17	Ascorbinsyretocopherylphosphatdiestere til hæmning af Maillards reaktion
FI894045A0 (fi)	1989-08-29	Menetelmä terapeuttisesti aktiivisen 10-atsaspiro-9-fluori-2,3-dihydro-3-metyyli-7-okso-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihappojohdannaisen valmistamiseksi
ES2039356T3 (es)	1993-10-01	Un procedimiento para la preparacion de derivados del acido p-guanidinobenzoico.
DK390587A (da)	1988-01-29	7-oeoe3-aminomethyl-3-alkylaa-1-pyrrolidinylaa-quino lin-carboxylsyre
ATE102606T1 (de)	1994-03-15	Substituierte semicarbazon-arthropodizide.
ATE92489T1 (de)	1993-08-15	Imid-derivate, ihre herstellung und verwendung.
IE871374L (en)	1987-12-10	Variants of alpha-one-antitrypsin.
ES2044908T3 (es)	1994-01-16	Procedimiento para la produccion de derivados de quinazolina.
ATE86985T1 (de)	1993-04-15	Chinoxalinon-derivate.
ATE63541T1 (de)	1991-06-15	N-phenylethylaminoalkyl-benzamide als antiarrhythmische mittel.
NO892743D0 (no)	1989-07-03	Fremgangsmaate for fremstilling av farmakologisk aktive glycerolderivater.
ATE60779T1 (de)	1991-02-15	N-glykolylneuraminsaeurederivat.
DK348389A (da)	1990-01-15	Phenylpropenderivater
ES2031477T3 (es)	1992-12-16	Procedimiento para producir esteres de acido 1-hidroxi-5-oxo-5h-pirido/3,2-a/fenoxazin-3-carboxilico.
ES2051722T3 (es)	1994-07-01	Procedimiento para estabilizar derivados de procaterol.
DE3788761D1 (de)	1994-02-24	Physiologisch aktive Substanz FA-4283, Derivate und ihre Herstellung.
LU88449I2 (fr)	1994-09-09	Fleroxacine et ses dérivés pharmaceutiquement acceptables.