ES2075079T3 - Derivados de benzopirano. - Google Patents

Derivados de benzopirano.

Info

Publication number
ES2075079T3
ES2075079T3 ES90104680T ES90104680T ES2075079T3 ES 2075079 T3 ES2075079 T3 ES 2075079T3 ES 90104680 T ES90104680 T ES 90104680T ES 90104680 T ES90104680 T ES 90104680T ES 2075079 T3 ES2075079 T3 ES 2075079T3
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
formula
bond
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90104680T
Other languages
English (en)
Inventor
Shuichi Ohuchida
Masaaki Toda
Tsumoru Miyamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2075079T3 publication Critical patent/ES2075079T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

DICHO DERIVADO DE FORMULA (IA) DONDE: R1A ES UN HIDROGENO, ALQUIL C1-4, ALCOXI C1-4; O DOS R1A FORMADOS JUNTOS CON EL SEPTIMO Y EL OCTAVO CARBONO PARA EL CUAL SON UNIDOS FORMANDO UN ANILLO CARBOCICLICO C6; R2A ES HIDROGENO, ALQUIL C1-4 O ALCOXI C1-4; R3A ES HIDROGENO, ACIL C2-4 O BENZOIL; HA ES 1-4; YA ES ALQUILENO C1-7, ALQUENILO C2-7 O ALQUENILENO C2-7; MA ES I) ENLACE, II) UN GRUPO DE FORMULA -DA-BA-; DA ES I) -O-OR, II) -S-, BA ES I) ALQUILENO C1-4, II) UN GRUPO DE FORMULA.
ES90104680T 1989-03-13 1990-03-12 Derivados de benzopirano. Expired - Lifetime ES2075079T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6031789 1989-03-13
JP28280589 1989-10-30

Publications (1)

Publication Number Publication Date
ES2075079T3 true ES2075079T3 (es) 1995-10-01

Family

ID=26401387

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90104680T Expired - Lifetime ES2075079T3 (es) 1989-03-13 1990-03-12 Derivados de benzopirano.

Country Status (10)

Country Link
US (1) US5055598A (es)
EP (1) EP0387771B1 (es)
JP (1) JP2955717B2 (es)
KR (1) KR0156538B1 (es)
AT (1) ATE123491T1 (es)
CA (1) CA2011899A1 (es)
DE (1) DE69019849T2 (es)
DK (1) DK0387771T3 (es)
ES (1) ES2075079T3 (es)
GR (1) GR3016985T3 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP0550292A1 (en) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Tissue protective tocopherol analogs
SI9300097B (en) * 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
US5703115A (en) * 1993-02-19 1997-12-30 Janssen Pharmaceutica, N.V. (benzodioxan, benzofuran or benzopyran) alkylamino! alkyl substituted guanidines
US5607966A (en) * 1994-12-23 1997-03-04 Alcon Laboratories, Inc. Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs
US5925673A (en) * 1994-12-23 1999-07-20 Alcon Laboratories, Inc. Benzofurans and benzopyrans as cytoprotective agents
US5643943A (en) * 1994-12-23 1997-07-01 Alcon Laboratories, Inc. Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
US5811453A (en) 1994-12-23 1998-09-22 Alcon Laboratories, Inc. Viscoelastic compositions and methods of use
US5750564A (en) * 1995-09-12 1998-05-12 Hellberg; Mark Anti-oxidant esters of non-steroidal anti-inflammatory agents
US6197806B1 (en) 1995-12-20 2001-03-06 Nippon Zoki Pharmaceutical Co., Ltd. Eliminating agent for activated oxygen and free radicals
US5747528A (en) * 1996-02-21 1998-05-05 Warner-Lambert Company Chroman derivatives as anti-oxidants
IT1289494B1 (it) * 1996-12-20 1998-10-15 Biomedica Foscana Ind Chimico Acidi 5-idrossi- e 5-acilossi-2,3-diidro-4,6,7-trimetil-2- benzofuranaceti e loro esteri per il trattamento e la prevenzione
CA2319131A1 (en) 1998-01-26 1999-07-29 Walter H. Moos Mitochondria protecting agents for treating mitochondria associated diseases
JP3811008B2 (ja) 1998-08-24 2006-08-16 黒川 清 カルボニルストレス状態改善剤、および腹膜透析液
AU754989B2 (en) 1998-11-16 2002-11-28 Nippon Zoki Pharmaceutical Co., Ltd. A therapeutic agent for intractable vasculitis
US6503949B1 (en) 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
JP4711523B2 (ja) 2001-02-13 2011-06-29 日本臓器製薬株式会社 低アルブミン血症改善剤
FR2822463B1 (fr) * 2001-03-21 2004-07-30 Lipha Derives bicycliques de guanidines et leurs applications en therapeutique
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
WO2005033092A1 (en) * 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Chroman derivatives
US7384558B2 (en) * 2004-07-26 2008-06-10 Baxter International Inc. Compositions capable of inhibiting reactive oxygen and carbonyl species
KR102634384B1 (ko) * 2023-03-28 2024-02-06 자경케미칼 주식회사 헤테로사이클릭 아미노산의 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0631207B2 (ja) * 1985-05-13 1994-04-27 株式会社クラレ ３，４−ジヒドロベンゾピラン誘導体類及びこれを有効成分とする抗消化性潰瘍剤
EP0202580B1 (en) * 1985-05-13 1990-03-28 Kuraray Co., Ltd. 3,4-dihydrobenzopyran derivatives

Also Published As

Publication number Publication date
CA2011899A1 (en) 1990-09-13
JP2955717B2 (ja) 1999-10-04
US5055598A (en) 1991-10-08
DK0387771T3 (da) 1995-07-31
EP0387771A2 (en) 1990-09-19
JPH03204874A (ja) 1991-09-06
KR0156538B1 (ko) 1998-11-16
DE69019849D1 (de) 1995-07-13
EP0387771A3 (en) 1990-12-27
DE69019849T2 (de) 1995-11-16
GR3016985T3 (en) 1995-11-30
ATE123491T1 (de) 1995-06-15
EP0387771B1 (en) 1995-06-07
KR900014350A (ko) 1990-10-23

Similar Documents

Publication Publication Date Title
ES2075079T3 (es) Derivados de benzopirano.
FR2372804A1 (fr) Derives d'amino-acides, en tant qu'agents anti-hypertension
NL960019I1 (nl) Moforlino-ethylester van mycofenolzuur en derivaten ervan, de bereiding ervan en hun toepassing in farmaceutische samenstellingen.
DE69019111D1 (de) Ascorbinsäure-Tocopheryl-Phosphatdiester zur Hemmung der Maillard-Reaktion.
ES2039356T3 (es) Un procedimiento para la preparacion de derivados del acido p-guanidinobenzoico.
DK390587D0 (da) 7-oeoe3-aminomethyl-3-alkylaa-1-pyrrolidinylaa-quino lin-carboxylsyre
DE68913706D1 (de) Substituierte Semicarbazon-Arthropodizide.
ATE92489T1 (de) Imid-derivate, ihre herstellung und verwendung.
ES2083954T3 (es) Proceso para la preparacion de compuestos de piridina fundidos.
IE871374L (en) Variants of alpha-one-antitrypsin.
ES2044908T3 (es) Procedimiento para la produccion de derivados de quinazolina.
ATE86985T1 (de) Chinoxalinon-derivate.
ATE63541T1 (de) N-phenylethylaminoalkyl-benzamide als antiarrhythmische mittel.
NO892743D0 (no) Fremgangsmaate for fremstilling av farmakologisk aktive glycerolderivater.
ATE60779T1 (de) N-glykolylneuraminsaeurederivat.
DK348389A (da) Phenylpropenderivater
ES2031477T3 (es) Procedimiento para producir esteres de acido 1-hidroxi-5-oxo-5h-pirido/3,2-a/fenoxazin-3-carboxilico.
DE69331814D1 (de) Salze von Glukopyranosederivate und ihre Zwischenprodukte
ES2051722T3 (es) Procedimiento para estabilizar derivados de procaterol.
DE3788761D1 (de) Physiologisch aktive Substanz FA-4283, Derivate und ihre Herstellung.
EP0276124A3 (en) Prostaglandin derivatives, their preparation and their therapeutic use

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 387771

Country of ref document: ES