DK0398143T3 - Mærkede kemotaktiske peptider til visualisering af infektions- eller inflammationssteder - Google Patents

Mærkede kemotaktiske peptider til visualisering af infektions- eller inflammationssteder

Info

Publication number: DK0398143T3
Authority: DK; Denmark
Prior art keywords: chemotactic peptides; infection; inflammation sites; labeled chemotactic; visualizing
Prior art date: 1989-05-09

Application number

DK90108734.6T

Other languages

Danish (da)

English (en)

Inventor

Alan Jay Fischman

Harry William Strauss

Anthony Joseph Fuccello

Douglas James Riexinger

Robert Harold Rubin

Daniel John Kroon

Original Assignee

Gen Hospital Corp

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-09

Filing date

1990-05-09

Publication date

1995-05-22

1990-05-09 Application filed by Gen Hospital Corp, Ortho Pharma Corp filed Critical Gen Hospital Corp

1995-05-22 Application granted granted Critical

1995-05-22 Publication of DK0398143T3 publication Critical patent/DK0398143T3/da

Links

101710091342 Chemotactic peptide Proteins 0.000 title abstract 3
206010061218 Inflammation Diseases 0.000 title abstract 2
208000015181 infectious disease Diseases 0.000 title abstract 2
230000004054 inflammatory process Effects 0.000 title abstract 2
239000000203 mixture Substances 0.000 abstract 2
KFKWRHQBZQICHA-STQMWFEESA-N L-leucyl-L-phenylalanine Natural products CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 KFKWRHQBZQICHA-STQMWFEESA-N 0.000 abstract 1
108010044056 leucyl-phenylalanine Proteins 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Oncology (AREA)
Genetics & Genomics (AREA)
Communicable Diseases (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicinal Preparation (AREA)
Respiratory Apparatuses And Protective Means (AREA)
Iron Core Of Rotating Electric Machines (AREA)

DK90108734.6T 1989-05-09 1990-05-09 Mærkede kemotaktiske peptider til visualisering af infektions- eller inflammationssteder DK0398143T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34918689A	1989-05-09	1989-05-09

Publications (1)

Publication Number	Publication Date
DK0398143T3 true DK0398143T3 (da)	1995-05-22

Family

ID=23371254

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90108734.6T DK0398143T3 (da)	1989-05-09	1990-05-09	Mærkede kemotaktiske peptider til visualisering af infektions- eller inflammationssteder

Country Status (14)

Country	Link
EP (1)	EP0398143B1 (fr)
JP (1)	JP2931093B2 (fr)
KR (1)	KR0185995B1 (fr)
AT (1)	ATE119784T1 (fr)
AU (1)	AU644364B2 (fr)
CA (1)	CA2016235C (fr)
DE (1)	DE69017751T2 (fr)
DK (1)	DK0398143T3 (fr)
ES (1)	ES2072329T3 (fr)
FI (1)	FI106467B (fr)
NO (1)	NO309326B1 (fr)
NZ (2)	NZ233601A (fr)
WO (1)	WO1990013317A1 (fr)
ZA (1)	ZA903517B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5376356A (en) *	1989-03-14	1994-12-27	Neorx Corporation	Imaging tissue sites of inflammation
US5792444A (en) *	1989-05-09	1998-08-11	The General Hospital Corporation	Labeled chemotactic peptides to image focal sites of infection or inflammation
US5700444A (en) *	1992-02-20	1997-12-23	Rhomed Incorporated	Chemotactic peptide pharmaceutical applications
US5985240A (en) *	1989-08-09	1999-11-16	Rhomed Incorporated	Peptide radiopharmaceutical applications
CA2065299C (fr) *	1989-08-09	2001-07-24	Buck A. Rhodes	Radio-etiquetage direct des anticorps et d'autres proteines a l'aide de technetium ou de rhenium
US5759515A (en) *	1989-08-09	1998-06-02	Rhomed Incorporated	Polyvalent peptide pharmaceutical applications
US5443816A (en) *	1990-08-08	1995-08-22	Rhomed Incorporated	Peptide-metal ion pharmaceutical preparation and method
US5206023A (en) *	1991-01-31	1993-04-27	Robert F. Shaw	Method and compositions for the treatment and repair of defects or lesions in cartilage
US6019958A (en) *	1991-02-08	2000-02-01	Diatide, Inc.	Technetium-99m labeled peptides for imaging inflammation
US5997844A (en) *	1991-02-08	1999-12-07	Diatide, Inc.	Technetium-99m labeled peptides for imaging
US5965107A (en) *	1992-03-13	1999-10-12	Diatide, Inc.	Technetium-99m labeled peptides for imaging
US5645815A (en) *	1991-02-08	1997-07-08	Diatide, Inc.	Radiolabled compounds for thrombus imaging
US6107459A (en) *	1991-02-08	2000-08-22	Diatide, Inc.	Technetium-99m labeled peptides for diagnostic imaging
JP2774378B2 (ja) *	1991-02-08	1998-07-09	ダイアテク，インコーポレイテッド	映像用テクネチウム−９９ｍ標識化ポリペプチド
US5552525A (en) *	1991-02-08	1996-09-03	Diatech Inc.	Technetium-99m labeled peptides for imaging inflammation
US5561220A (en) *	1991-02-08	1996-10-01	Diatech, Inc.	Technetium-99m labeled peptides for imaging inflammation
US5270300A (en) *	1991-09-06	1993-12-14	Robert Francis Shaw	Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5738838A (en) *	1992-02-20	1998-04-14	Rhomed Incorporated	IKVAV peptide radiopharmaceutical applications
DE69231586T2 (de) *	1992-01-03	2001-07-19	Rhomed, Inc.	Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
US5556609A (en) *	1992-02-20	1996-09-17	Rhomed Incorporated	YIGSR peptide radiopharmaceutical applications
US5643549A (en) *	1992-02-20	1997-07-01	Rhomed Incorporated	Leukostimulatory agent for in vivo leukocyte tagging
AU683015B2 (en) *	1992-03-13	1997-10-30	Diatech, Inc.	Technetium-99m labeled peptides for imaging inflammation
US5989519A (en) *	1992-03-13	1999-11-23	Diatide, Inc.	Technetium-99m labeled peptides for imaging inflammation
US5413778A (en) *	1992-10-05	1995-05-09	The Regents Of The University Of Michigan	Labelled monocyte chemoattractant protein material and medical uses thereof
US5605671A (en) *	1992-10-05	1997-02-25	The Regents Of The University Of Michigan	Radiolabeled neutrophil activating peptides for imaging
US5346686A (en) *	1992-10-05	1994-09-13	Mallinckrodt Medical, Inc.	Labelled interleukin-8 and medical uses thereof
AU5537994A (en) *	1992-10-22	1994-05-09	Mallinckrodt Medical, Inc.	Therapeutic treatment for inhibiting vascular restenosis
US5480970A (en) *	1993-12-22	1996-01-02	Resolution Pharmaceuticals	Metal chelators
EP0709100A1 (fr) *	1994-09-30	1996-05-01	Nihon Medi-Physics Co., Ltd.	Agent de contraste contenant plusieurs groupes de détection par molécule
US5891418A (en) *	1995-06-07	1999-04-06	Rhomed Incorporated	Peptide-metal ion pharmaceutical constructs and applications
JPH10511701A (ja) *	1995-10-19	1998-11-10	ブラッコインターナショナルベスローテンフエンノートシャップ	生体組織のｎｍｒイメージングにおける標的コントラスト剤としての磁気標識化学誘引剤
US5910300A (en) *	1995-11-01	1999-06-08	Bracco Research S.A.	Amphiphilic linkers for coupling administrable diagnostically or physiologically active agents and bioselective targeting compounds
US6331285B1 (en)	1996-06-05	2001-12-18	Palatin Technologies, Inc.	Structurally determined cyclic metallo-constructs and applications
BR9815288A (pt)	1997-11-13	2001-02-13	Histatek Llc	Composição farmacêutica, processos para inibir a desgranulação de mastócitos, para tratar asma em um paciente, para tratar inflamação em um paciente, para inibir a liberação de citocinas em um paciente, para inibir a liberação de histaminas em um paciente, para inibir a liberação de leucotrienos em um paciente, para reduzir a adesão, migração e agregação de linfócitos, eosinófilos e neutrófilos para um sìtio de inflamação em um paciente, para reduzir a produção de anticorpos ige no sìtio de inflamação em um paciente, para inibir a permeabilidade vascular aumentada no sìtio de inflamação em um paciente, e, para tratar inflamação crÈnica em um paciente.
US6872536B1 (en) *	1998-11-10	2005-03-29	Bracco Imaging S.P.A.	Chemotactic peptide antagonists for imaging sites of inflammation
AU1801899A (en) *	1998-12-03	2000-06-19	Histatek, Llc	Small peptides and methods for treatment of asthma and inflammation
US6685914B1 (en)	1999-09-13	2004-02-03	Bristol-Myers Squibb Pharma Company	Macrocyclic chelants for metallopharmaceuticals
US7385025B2 (en)	2000-12-19	2008-06-10	Palatin Technologies, Inc.	Metallopeptide compounds
AU2002332042A1 (en) *	2001-10-05	2003-04-22	United States Of America As Represented By The Secretary Of The Navy	N-formyl peptide receptor mediation of platelet chemotaxis toward injured cells and activation of immune response
US7220827B2 (en)	2002-09-27	2007-05-22	Nihon Medi-Physics Co., Ltd.	Compound binding to leukocytes and medicinal composition containing the compound in labeled state as the active ingredient
US7319149B2 (en)	2003-06-13	2008-01-15	Bristol-Myers Squibb Pharma Company	Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en)	2003-06-13	2008-01-08	Bristol-Myers Squibb Pharma Company	Chelants and macrocyclic metal complex radiopharmaceuticals thereof
JP5994971B2 (ja)	2011-03-30	2016-09-21	日本メジフィジックス株式会社	炎症部位集積性化合物、核医学画像診断剤及び標識前駆体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU597032B2 (en) *	1986-01-16	1990-05-24	General Hospital Corporation, The	Method for the diagnosis and treatment of inflammation

1990
- 1990-05-08 NZ NZ233601A patent/NZ233601A/en unknown
- 1990-05-08 CA CA002016235A patent/CA2016235C/fr not_active Expired - Fee Related
- 1990-05-08 NZ NZ314680A patent/NZ314680A/xx active IP Right Revival
- 1990-05-09 WO PCT/US1990/002572 patent/WO1990013317A1/fr not_active Ceased
- 1990-05-09 DK DK90108734.6T patent/DK0398143T3/da active
- 1990-05-09 AU AU56590/90A patent/AU644364B2/en not_active Ceased
- 1990-05-09 KR KR1019910701566A patent/KR0185995B1/ko not_active Expired - Fee Related
- 1990-05-09 JP JP2507823A patent/JP2931093B2/ja not_active Expired - Fee Related
- 1990-05-09 AT AT90108734T patent/ATE119784T1/de not_active IP Right Cessation
- 1990-05-09 ES ES90108734T patent/ES2072329T3/es not_active Expired - Lifetime
- 1990-05-09 ZA ZA903517A patent/ZA903517B/xx unknown
- 1990-05-09 EP EP90108734A patent/EP0398143B1/fr not_active Expired - Lifetime
- 1990-05-09 DE DE69017751T patent/DE69017751T2/de not_active Expired - Fee Related
1991
- 1991-11-06 FI FI915249A patent/FI106467B/fi not_active IP Right Cessation
- 1991-11-07 NO NO914354A patent/NO309326B1/no unknown

Also Published As

Publication number	Publication date
AU5659090A (en)	1990-11-29
FI915249A0 (fi)	1991-11-06
CA2016235A1 (fr)	1990-11-09
WO1990013317A1 (fr)	1990-11-15
FI106467B (fi)	2001-02-15
EP0398143B1 (fr)	1995-03-15
ES2072329T3 (es)	1995-07-16
DE69017751T2 (de)	1995-07-13
NO309326B1 (no)	2001-01-15
NO914354D0 (no)	1991-11-07
NZ233601A (en)	1997-06-24
DE69017751D1 (de)	1995-04-20
ZA903517B (en)	1991-03-27
JPH04505761A (ja)	1992-10-08
KR0185995B1 (ko)	1999-05-01
CA2016235C (fr)	2002-03-12
ATE119784T1 (de)	1995-04-15
NO914354L (no)	1992-01-07
JP2931093B2 (ja)	1999-08-09
KR920700700A (ko)	1992-08-10
NZ314680A (en)	2000-08-25
AU644364B2 (en)	1993-12-09
EP0398143A1 (fr)	1990-11-22

Publication	Publication Date	Title
DK0398143T3 (da)	1995-05-22	Mærkede kemotaktiske peptider til visualisering af infektions- eller inflammationssteder
DK0695757T3 (da)	2002-08-19	Peptidamider til inhibering af human cancer
DE3676670D1 (de)	1991-02-07	Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung.
LU90458I2 (fr)	2001-04-13	Refacto
ATE87655T1 (de)	1993-04-15	Markierer der t-zelle aktivierung.
KR910700062A (ko)	1991-03-13	마가이닌 펩타이드의 결실 동족체
ES2179587T3 (es)	2003-01-16	Utilizacion de betainas como agentes antitranspirantes.
FI961737A0 (fi)	1996-04-22	Leimatut kemotaktiset peptidit infektio- tai tulehduskohtien kuvaamiseksi
NO303783B1 (no)	1998-08-31	Substituerte aminofosfonatderivater og farmas°ytiske preparater derav
ATE172216T1 (de)	1998-10-15	Konjugate von calcitonin und polyethylenglycol
ATE24917T1 (de)	1987-01-15	Peptide-derivate, deren herstellung und verwendung als elastasehemmende mittel.
DE69009795D1 (de)	1994-07-21	Muramylpeptid-Derivate und diese enthaltende immunregulierende Zusammensetzungen.
DK0463053T3 (da)	1998-10-07	Fremstilling og anvendelse af anthelmintiske midler og beskyttende immunogener
DE69018275D1 (de)	1995-05-11	Peptide, deren Verwendung als Hemmer gegen Entwicklung von t-Lymphocyten und Wirksamkeit von Makrophagen und Verfahren zu deren Herstellung.
DK0428352T3 (da)	1995-12-27	Antiinflammatoriske præparater til udvendig anvendelse
DE3485017D1 (de)	1991-10-10	Antikoerper und antikoerper enthaltende zubereitungen fuer die inhibition von periodontitis.
ITBO920036A1 (it)	1993-08-07	Dispositivo per l'applicazione di etichette ad involucri
DK1612555T3 (da)	2009-02-09	Kryptiske peptider til anvendelse til at inducere immunologisk tolerance
NO172895C (no)	1993-09-22	Peptid-aminoalkylamider, deres anvendelse for fremstilling av peptider samt en fremgangsmaate for fremstilling av slike peptider
FR2710243B3 (fr)	1995-10-13	Composition énergétique à base d'acides aminés à chaîne ramifiée.
ATE136586T1 (de)	1996-04-15	Protektive plasmodium falciparum hybridproteine, die teilsequenzen der malaria-antigene hrpii und serp enthalten
ES2023746A6 (es)	1992-02-01	Procedimiento de preparacion de peptidos de serina-acido aspartico- lisina
ATE158587T1 (de)	1997-10-15	Galactosamin-substituierte poly-omega- substituierte l-glutaminsäure und/oder - asparaginsäure
ES2091571T3 (es)	1996-11-01	Nuevos derivados peptidicos activos en los procesos de adhesion celular, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DE68901361D1 (de)	1992-06-04	Anorexigenische und hypotensive peptide.