ZA903517B - Labeled chemotactic peptides to image focal sites of infection or inflammation - Google Patents

Labeled chemotactic peptides to image focal sites of infection or inflammation

Info

Publication number
ZA903517B
ZA903517B ZA903517A ZA903517A ZA903517B ZA 903517 B ZA903517 B ZA 903517B ZA 903517 A ZA903517 A ZA 903517A ZA 903517 A ZA903517 A ZA 903517A ZA 903517 B ZA903517 B ZA 903517B
Authority
ZA
South Africa
Prior art keywords
inflammation
infection
chemotactic peptides
image focal
focal sites
Prior art date
Application number
ZA903517A
Other languages
English (en)
Inventor
Alan Jay Fischman
Jay Fischman Alan
Robert Harold Rubin
Harold Rubin Robert
Harry William Strauss
William Strauss Harry
Anthony Joseph Fuccello
Joseph Fuccello Anthony
Daniel John Kroon
John Kroon Daniel
Douglas James Riexinger
James Riexinger Douglas
Original Assignee
Gen Hospital Corp & Mcneilab I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp & Mcneilab I filed Critical Gen Hospital Corp & Mcneilab I
Publication of ZA903517B publication Critical patent/ZA903517B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
ZA903517A 1989-05-09 1990-05-09 Labeled chemotactic peptides to image focal sites of infection or inflammation ZA903517B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34918689A 1989-05-09 1989-05-09

Publications (1)

Publication Number Publication Date
ZA903517B true ZA903517B (en) 1991-03-27

Family

ID=23371254

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA903517A ZA903517B (en) 1989-05-09 1990-05-09 Labeled chemotactic peptides to image focal sites of infection or inflammation

Country Status (14)

Country Link
EP (1) EP0398143B1 (fr)
JP (1) JP2931093B2 (fr)
KR (1) KR0185995B1 (fr)
AT (1) ATE119784T1 (fr)
AU (1) AU644364B2 (fr)
CA (1) CA2016235C (fr)
DE (1) DE69017751T2 (fr)
DK (1) DK0398143T3 (fr)
ES (1) ES2072329T3 (fr)
FI (1) FI106467B (fr)
NO (1) NO309326B1 (fr)
NZ (2) NZ233601A (fr)
WO (1) WO1990013317A1 (fr)
ZA (1) ZA903517B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376356A (en) * 1989-03-14 1994-12-27 Neorx Corporation Imaging tissue sites of inflammation
US5792444A (en) * 1989-05-09 1998-08-11 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
CA2065299C (fr) * 1989-08-09 2001-07-24 Buck A. Rhodes Radio-etiquetage direct des anticorps et d'autres proteines a l'aide de technetium ou de rhenium
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
DE69231586T2 (de) * 1992-01-03 2001-07-19 Rhomed, Inc. Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
AU683015B2 (en) * 1992-03-13 1997-10-30 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5989519A (en) * 1992-03-13 1999-11-23 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5413778A (en) * 1992-10-05 1995-05-09 The Regents Of The University Of Michigan Labelled monocyte chemoattractant protein material and medical uses thereof
US5605671A (en) * 1992-10-05 1997-02-25 The Regents Of The University Of Michigan Radiolabeled neutrophil activating peptides for imaging
US5346686A (en) * 1992-10-05 1994-09-13 Mallinckrodt Medical, Inc. Labelled interleukin-8 and medical uses thereof
AU5537994A (en) * 1992-10-22 1994-05-09 Mallinckrodt Medical, Inc. Therapeutic treatment for inhibiting vascular restenosis
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
EP0709100A1 (fr) * 1994-09-30 1996-05-01 Nihon Medi-Physics Co., Ltd. Agent de contraste contenant plusieurs groupes de détection par molécule
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
JPH10511701A (ja) * 1995-10-19 1998-11-10 ブラッコ インターナショナル ベスローテン フエンノートシャップ 生体組織のｎｍｒイメージングにおける標的コントラスト剤としての磁気標識化学誘引剤
US5910300A (en) * 1995-11-01 1999-06-08 Bracco Research S.A. Amphiphilic linkers for coupling administrable diagnostically or physiologically active agents and bioselective targeting compounds
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
BR9815288A (pt) 1997-11-13 2001-02-13 Histatek Llc Composição farmacêutica, processos para inibir a desgranulação de mastócitos, para tratar asma em um paciente, para tratar inflamação em um paciente, para inibir a liberação de citocinas em um paciente, para inibir a liberação de histaminas em um paciente, para inibir a liberação de leucotrienos em um paciente, para reduzir a adesão, migração e agregação de linfócitos, eosinófilos e neutrófilos para um sìtio de inflamação em um paciente, para reduzir a produção de anticorpos ige no sìtio de inflamação em um paciente, para inibir a permeabilidade vascular aumentada no sìtio de inflamação em um paciente, e, para tratar inflamação crÈnica em um paciente.
US6872536B1 (en) * 1998-11-10 2005-03-29 Bracco Imaging S.P.A. Chemotactic peptide antagonists for imaging sites of inflammation
AU1801899A (en) * 1998-12-03 2000-06-19 Histatek, Llc Small peptides and methods for treatment of asthma and inflammation
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
AU2002332042A1 (en) * 2001-10-05 2003-04-22 United States Of America As Represented By The Secretary Of The Navy N-formyl peptide receptor mediation of platelet chemotaxis toward injured cells and activation of immune response
US7220827B2 (en) 2002-09-27 2007-05-22 Nihon Medi-Physics Co., Ltd. Compound binding to leukocytes and medicinal composition containing the compound in labeled state as the active ingredient
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
JP5994971B2 (ja) 2011-03-30 2016-09-21 日本メジフィジックス株式会社 炎症部位集積性化合物、核医学画像診断剤及び標識前駆体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU597032B2 (en) * 1986-01-16 1990-05-24 General Hospital Corporation, The Method for the diagnosis and treatment of inflammation

Also Published As

Publication number Publication date
AU5659090A (en) 1990-11-29
FI915249A0 (fi) 1991-11-06
CA2016235A1 (fr) 1990-11-09
WO1990013317A1 (fr) 1990-11-15
FI106467B (fi) 2001-02-15
EP0398143B1 (fr) 1995-03-15
ES2072329T3 (es) 1995-07-16
DE69017751T2 (de) 1995-07-13
NO309326B1 (no) 2001-01-15
NO914354D0 (no) 1991-11-07
NZ233601A (en) 1997-06-24
DE69017751D1 (de) 1995-04-20
DK0398143T3 (da) 1995-05-22
JPH04505761A (ja) 1992-10-08
KR0185995B1 (ko) 1999-05-01
CA2016235C (fr) 2002-03-12
ATE119784T1 (de) 1995-04-15
NO914354L (no) 1992-01-07
JP2931093B2 (ja) 1999-08-09
KR920700700A (ko) 1992-08-10
NZ314680A (en) 2000-08-25
AU644364B2 (en) 1993-12-09
EP0398143A1 (fr) 1990-11-22

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