DK0399504T3 - Aryloxyphenylpropylaminer og deres fremstilling og anvendelse - Google Patents
Aryloxyphenylpropylaminer og deres fremstilling og anvendelseInfo
- Publication number
- DK0399504T3 DK0399504T3 DK90109829.3T DK90109829T DK0399504T3 DK 0399504 T3 DK0399504 T3 DK 0399504T3 DK 90109829 T DK90109829 T DK 90109829T DK 0399504 T3 DK0399504 T3 DK 0399504T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- cycloalkyl
- alkoxy
- aryloxy
- cyano
- Prior art date
Links
- 125000004104 aryloxy group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- -1 3,4-methylenedioxy Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 abstract 1
- 206010002660 Anoxia Diseases 0.000 abstract 1
- 241000976983 Anoxia Species 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000007953 anoxia Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000008736 traumatic injury Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Luminescent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK258389A DK258389D0 (da) | 1989-05-26 | 1989-05-26 | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0399504T3 true DK0399504T3 (da) | 1995-09-04 |
Family
ID=8113376
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK258389A DK258389D0 (da) | 1989-05-26 | 1989-05-26 | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
| DK90109829.3T DK0399504T3 (da) | 1989-05-26 | 1990-05-23 | Aryloxyphenylpropylaminer og deres fremstilling og anvendelse |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK258389A DK258389D0 (da) | 1989-05-26 | 1989-05-26 | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5145870A (da) |
| EP (1) | EP0399504B1 (da) |
| JP (1) | JPH0317046A (da) |
| AT (1) | ATE122031T1 (da) |
| AU (1) | AU641653B2 (da) |
| CA (1) | CA2017468A1 (da) |
| DE (1) | DE69019060T2 (da) |
| DK (2) | DK258389D0 (da) |
| ES (1) | ES2071699T3 (da) |
| FI (1) | FI902629A7 (da) |
| IE (1) | IE70070B1 (da) |
| IL (1) | IL94452A (da) |
| NO (1) | NO174342C (da) |
| NZ (1) | NZ233809A (da) |
| PT (1) | PT94167B (da) |
| ZA (1) | ZA904072B (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0576766A1 (en) * | 1992-06-29 | 1994-01-05 | Novo Nordisk A/S | Propanolamine derivatives, their preparation and use |
| US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6017965A (en) * | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6211245B1 (en) | 1993-02-08 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6750244B2 (en) | 1993-02-08 | 2004-06-15 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US7087765B2 (en) | 1995-06-07 | 2006-08-08 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| KR100366745B1 (ko) | 1994-02-08 | 2003-04-18 | 엔피에스 파마슈티칼즈, 인코포레이티드 | 신경 질환 및 신경 질병의 치료에 유용한 수용체-작동된 칼슘채널의 신규 부위에서 활성인 화합물 |
| DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| IT1304874B1 (it) * | 1998-07-17 | 2001-04-05 | Univ Firenze | Amminoalcoli,amminochetoni e loro derivati,loro preparazione ed usocome farmaci per le patologie del sistema nervoso centrale (snc) e |
| GB0004152D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0004153D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004151D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| SE0102641D0 (sv) * | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| SE0102640D0 (sv) | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| SE0102639D0 (sv) * | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| US6846957B2 (en) * | 2002-11-22 | 2005-01-25 | Board Of Regents, The University Of Texas System | Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor |
| WO2005063707A1 (en) * | 2003-12-26 | 2005-07-14 | Natco Pharma Limited | Enantiospecific process for the preparation of paroxetine intermediate |
| ITMI20061987A1 (it) * | 2006-10-16 | 2008-04-17 | Archimica Srl | Processo per la sintesi di arilossipropilammine ed eteroarilossipropilammine. |
| WO2008081477A1 (en) * | 2007-01-04 | 2008-07-10 | Natco Pharma Limited | 3-aryloxy 3-substituted propanamines |
| JP5246715B2 (ja) * | 2009-01-27 | 2013-07-24 | 独立行政法人科学技術振興機構 | 蛋白質架橋阻害剤およびその用途 |
| DE102009036164B4 (de) | 2009-05-28 | 2011-06-09 | Schott Ag | Verfahren zum Biegen und thermischen Vorspannen von Strahlenschutzglas |
| WO2014046544A1 (en) * | 2012-09-21 | 2014-03-27 | Aapa B.V. | Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3095449A (en) * | 1957-08-06 | 1963-06-25 | Bayer Ag | 1-(gamma-dimethylaminopropoxy)-2-alkoxy alkenylbenzenes |
| US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
| US4194009A (en) * | 1974-01-10 | 1980-03-18 | Eli Lilly And Company | Aryloxyphenylpropylamines for obtaining a psychotropic effect |
| CH609331A5 (en) * | 1974-01-10 | 1979-02-28 | Lilly Co Eli | Process for the preparation of 3-aryloxy-3-phenyl-propylamines |
| FR2432500A1 (fr) * | 1978-02-24 | 1980-02-29 | Roussel Uclaf | Nouveaux derives de la benzene propanamine et leurs sels, procede de preparation et application a titre de medicaments |
| DE2940765A1 (de) * | 1979-10-08 | 1981-04-23 | Basf Ag, 6700 Ludwigshafen | Substituierte alkylammoniumsalze, ihre herstellung, ihre verwendung zur regulierung des pflanzenwachstums und mittel dafuer |
| DE2950135A1 (de) * | 1979-12-13 | 1981-06-19 | Merck Patent Gmbh, 6100 Darmstadt | Basischer aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
| ZA817863B (en) * | 1980-11-14 | 1983-06-29 | Lilly Co Eli | (-)n-methyl-3-(2-methylphenoxy)-3-phenylpropylamnie,antidepressant |
| US4956388A (en) * | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| CA1329937C (en) * | 1987-04-09 | 1994-05-31 | Dennis Charles Thompson | 1-phenyl-3-naphthalenyloxypropanamines |
| DK630987D0 (da) * | 1987-12-01 | 1987-12-01 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
-
1989
- 1989-05-26 DK DK258389A patent/DK258389D0/da not_active Application Discontinuation
-
1990
- 1990-05-18 IE IE179090A patent/IE70070B1/en not_active IP Right Cessation
- 1990-05-21 IL IL9445290A patent/IL94452A/en not_active IP Right Cessation
- 1990-05-22 AU AU55821/90A patent/AU641653B2/en not_active Ceased
- 1990-05-23 AT AT90109829T patent/ATE122031T1/de not_active IP Right Cessation
- 1990-05-23 DE DE69019060T patent/DE69019060T2/de not_active Expired - Fee Related
- 1990-05-23 DK DK90109829.3T patent/DK0399504T3/da active
- 1990-05-23 EP EP90109829A patent/EP0399504B1/en not_active Expired - Lifetime
- 1990-05-23 ES ES90109829T patent/ES2071699T3/es not_active Expired - Lifetime
- 1990-05-24 CA CA002017468A patent/CA2017468A1/en not_active Abandoned
- 1990-05-24 JP JP2132771A patent/JPH0317046A/ja active Pending
- 1990-05-24 US US07/529,004 patent/US5145870A/en not_active Expired - Fee Related
- 1990-05-24 NZ NZ233809A patent/NZ233809A/en unknown
- 1990-05-25 NO NO902338A patent/NO174342C/no unknown
- 1990-05-25 FI FI902629A patent/FI902629A7/fi not_active Application Discontinuation
- 1990-05-25 PT PT94167A patent/PT94167B/pt not_active IP Right Cessation
- 1990-05-28 ZA ZA904072A patent/ZA904072B/xx unknown
-
1992
- 1992-06-12 US US07/898,060 patent/US5310756A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK258389D0 (da) | 1989-05-26 |
| US5310756A (en) | 1994-05-10 |
| ATE122031T1 (de) | 1995-05-15 |
| US5145870A (en) | 1992-09-08 |
| NZ233809A (en) | 1993-04-28 |
| NO902338L (no) | 1990-11-27 |
| AU5582190A (en) | 1990-11-29 |
| EP0399504A2 (en) | 1990-11-28 |
| NO174342B (no) | 1994-01-10 |
| NO174342C (no) | 1994-04-20 |
| IL94452A (en) | 1995-11-27 |
| AU641653B2 (en) | 1993-09-30 |
| NO902338D0 (no) | 1990-05-25 |
| ES2071699T3 (es) | 1995-07-01 |
| IE901790L (en) | 1990-11-26 |
| CA2017468A1 (en) | 1990-11-26 |
| FI902629A7 (fi) | 1990-11-27 |
| FI902629A0 (fi) | 1990-05-25 |
| JPH0317046A (ja) | 1991-01-25 |
| EP0399504B1 (en) | 1995-05-03 |
| EP0399504A3 (en) | 1992-02-12 |
| ZA904072B (en) | 1991-03-27 |
| PT94167B (pt) | 1996-12-31 |
| DE69019060T2 (de) | 1995-08-31 |
| IE70070B1 (en) | 1996-10-30 |
| DE69019060D1 (de) | 1995-06-08 |
| IL94452A0 (en) | 1991-03-10 |
| PT94167A (pt) | 1991-01-08 |
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