DK0399556T3 - Aminosubstituerede heterocycliske forbindelser som renininhibitorer - Google Patents

Aminosubstituerede heterocycliske forbindelser som renininhibitorer

Info

Publication number: DK0399556T3
Authority: DK; Denmark
Prior art keywords: amino; renin; substituted heterocyclic; heterocyclic compounds; renin inhibitors
Prior art date: 1989-05-26

Application number

DK90109990.3T

Other languages

Danish (da)

English (en)

Inventor

Cleo Conolly

Annette Marian Doherty

Harriet Wall Hamilton

William Chester Patt

Ila Sircar

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-26

Filing date

1990-05-25

Publication date

1995-05-29

1990-05-25 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1995-05-29 Application granted granted Critical

1995-05-29 Publication of DK0399556T3 publication Critical patent/DK0399556T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Crystallography & Structural Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Ophthalmology & Optometry (AREA)
Virology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)

DK90109990.3T 1989-05-26 1990-05-25 Aminosubstituerede heterocycliske forbindelser som renininhibitorer DK0399556T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35756189A	1989-05-26	1989-05-26
US07/511,271 US5238923A (en)	1989-05-26	1990-04-25	Amino-substituted heterocycles as renin inhibitors

Publications (1)

Publication Number	Publication Date
DK0399556T3 true DK0399556T3 (da)	1995-05-29

Family

ID=26999702

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90109990.3T DK0399556T3 (da)	1989-05-26	1990-05-25	Aminosubstituerede heterocycliske forbindelser som renininhibitorer

Country Status (15)

Country	Link
US (3)	US5238923A (de)
EP (1)	EP0399556B1 (de)
JP (1)	JP2980129B2 (de)
KR (1)	KR900018140A (de)
AT (1)	ATE116331T1 (de)
AU (1)	AU625354B2 (de)
CA (1)	CA2017552A1 (de)
DE (1)	DE69015437T2 (de)
DK (1)	DK0399556T3 (de)
ES (1)	ES2066905T3 (de)
FI (1)	FI902557A7 (de)
GR (1)	GR3015497T3 (de)
NO (1)	NO902318L (de)
NZ (1)	NZ233811A (de)
PT (1)	PT94159A (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE68045B1 (en) *	1990-05-11	1996-05-15	Abbott Lab	Renin inhibitors
US5178877A (en) *	1991-01-04	1993-01-12	Abbott Laboratories	Encapsulated renin inhibitor composition
US5089616A (en) *	1991-04-23	1992-02-18	Warner-Lambert Company	Process for the preparation of [1S-(1R,2S,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide
US5220031A (en) *	1991-04-23	1993-06-15	Warner-Lambert Company	Process for the preparation of [1S-(1R,2S3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide
US5516784A (en) *	1991-08-13	1996-05-14	Schering Corporation	Anti-HIV (AIDS) agents
WO1993006127A1 (en) *	1991-09-17	1993-04-01	Warner-Lambert Company	Novel amino acid prodrug renin inhibitors
US6677360B2 (en) *	1998-12-16	2004-01-13	Bayer Aktiengesellschaft	Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6420396B1 (en)	1998-12-16	2002-07-16	Beiersdorf Ag	Biphenyl and biphenyl-analogous compounds as integrin antagonists
AR039156A1 (es) *	2002-03-28	2005-02-09	Novartis Ag	Amidas del acido piperidinilamino sulfamico o piperazinil sulfamico y su uso para la manufactura de un medicamento en enfermedades mediadas por la accion de la sulfatasa esteroide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4845079A (en) *	1985-01-23	1989-07-04	Luly Jay R	Peptidylaminodiols
CA1286846C (en) *	1985-02-12	1991-07-23	Catherine Cazaubon	Peptide derivatives which inhibit renin and acid proteases
HU200473B (en) *	1985-11-01	1990-06-28	Pfizer	Process for producing polypeptides containing difluorocyclostatine and pharmaceutical compositions comprising same
US4839357A (en) *	1987-10-02	1989-06-13	Merck & Co., Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
US5063207A (en) *	1987-10-26	1991-11-05	Warner-Lambert Company	Renin inhibitors, method for using them, and compositions containing them
US5036053A (en) *	1988-05-27	1991-07-30	Warner-Lambert Company	Diol-containing renin inhibitors
US5178877A (en) *	1991-01-04	1993-01-12	Abbott Laboratories	Encapsulated renin inhibitor composition
US5219851A (en) *	1991-03-05	1993-06-15	Warner-Lambert Company	Tetrahydroisoquinoline-type renin inhibiting peptides
US5178887A (en) *	1991-04-10	1993-01-12	Ameron, Inc.	Compound fluted mold for casting prestressed concrete lamp poles

1990
- 1990-04-25 US US07/511,271 patent/US5238923A/en not_active Expired - Lifetime
- 1990-05-23 FI FI902557A patent/FI902557A7/fi not_active IP Right Cessation
- 1990-05-24 NZ NZ233811A patent/NZ233811A/en unknown
- 1990-05-24 AU AU55908/90A patent/AU625354B2/en not_active Ceased
- 1990-05-25 NO NO90902318A patent/NO902318L/no unknown
- 1990-05-25 AT AT90109990T patent/ATE116331T1/de not_active IP Right Cessation
- 1990-05-25 CA CA002017552A patent/CA2017552A1/en not_active Abandoned
- 1990-05-25 DK DK90109990.3T patent/DK0399556T3/da active
- 1990-05-25 PT PT94159A patent/PT94159A/pt not_active Application Discontinuation
- 1990-05-25 KR KR1019900007732A patent/KR900018140A/ko not_active Withdrawn
- 1990-05-25 JP JP2134257A patent/JP2980129B2/ja not_active Expired - Fee Related
- 1990-05-25 ES ES90109990T patent/ES2066905T3/es not_active Expired - Lifetime
- 1990-05-25 DE DE69015437T patent/DE69015437T2/de not_active Expired - Fee Related
- 1990-05-25 EP EP90109990A patent/EP0399556B1/de not_active Expired - Lifetime
1993
- 1993-03-26 US US08/038,728 patent/US5453488A/en not_active Expired - Fee Related
1995
- 1995-03-20 GR GR950400628T patent/GR3015497T3/el unknown
- 1995-05-15 US US08/440,585 patent/US5643879A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5643879A (en)	1997-07-01
AU5590890A (en)	1990-11-29
KR900018140A (ko)	1990-12-20
JP2980129B2 (ja)	1999-11-22
EP0399556A1 (de)	1990-11-28
US5453488A (en)	1995-09-26
NO902318D0 (no)	1990-05-25
NO902318L (no)	1990-11-27
ATE116331T1 (de)	1995-01-15
US5238923A (en)	1993-08-24
NZ233811A (en)	1992-10-28
JPH0386870A (ja)	1991-04-11
FI902557A0 (fi)	1990-05-23
DE69015437D1 (de)	1995-02-09
DE69015437T2 (de)	1995-05-04
FI902557A7 (fi)	1990-11-27
CA2017552A1 (en)	1990-11-26
PT94159A (pt)	1991-02-08
GR3015497T3 (en)	1995-06-30
ES2066905T3 (es)	1995-03-16
EP0399556B1 (de)	1994-12-28
AU625354B2 (en)	1992-07-09

Publication	Publication Date	Title
EP0343654A3 (de)	1991-05-29	Diol enthaltende Renininhibitoren
AU3416584A (en)	1986-09-11	Blood-pressure lowering piperazine derivatives
ATE396988T1 (de)	2008-06-15	Chinolin- und chianzolinderivate zur behandlung von tumoren
ES2036562T3 (es)	1993-06-01	Un procedimiento para produccion de un derivado de pirrolidinamida.
AU625354B2 (en)	1992-07-09	Amino-substituted heterocycles as renin inhibitors
DE69406323D1 (de)	1997-11-27	Substituierte Aminsäure Derivate verwendbar für die Behandlung von Arteriosclerosis
NO161564C (no)	1989-08-30	Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-oxadiazolylderivater.
DE69015885D1 (de)	1995-02-23	Enzyminhibitoren.
DK147588D0 (da)	1988-03-17	Benzoxazinderivat samt fremgangsmaade til fremstilling deraf
NO173991C (no)	1994-03-02	Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,5-ditiazocin-derivater
ES2106439T3 (es)	1997-11-01	5-(piperazinilalquil)-1,5-benzotiazepinonas utiles como antagonistas de calcio.
NO164474C (no)	1990-10-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive heksahydropyrrolo(2,1-a)isokinolin-derivater.
NO159927C (no)	1989-02-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive aromatiske aminoacetylener.
MX9703363A (es)	1998-02-28	Nuevos derivados de pirimidiniloxi- y pirimidinilamino etilfenil-dioxolano.
PT89492A (pt)	1989-10-04	Processo de preparacao de novos derivados de tioformamida terapeuticamente activos
DK360388A (da)	1989-01-02	Laegemiddel til behandling af hjerteinsufficiens
DE69213264D1 (de)	1996-10-10	Verfahren zur Herstellung von Fluorbenzolderivaten und verwandter Verbindungen
DK284080A (da)	1981-01-03	Fremgangsmaade til fremstilling af clavulansyrederivater
CA2198266A1 (en)	1997-01-30	Novel benzimidazole derivatives