DK0399633T3 - Leukotrien B4-derivater, fremgangsmåde til fremstilling heraf samt deres anvendelse som lægemiddel - Google Patents

Leukotrien B4-derivater, fremgangsmåde til fremstilling heraf samt deres anvendelse som lægemiddel

Info

Publication number
DK0399633T3
DK0399633T3 DK90250136.0T DK90250136T DK0399633T3 DK 0399633 T3 DK0399633 T3 DK 0399633T3 DK 90250136 T DK90250136 T DK 90250136T DK 0399633 T3 DK0399633 T3 DK 0399633T3
Authority
DK
Denmark
Prior art keywords
image
pct
group
trans
sec
Prior art date
Application number
DK90250136.0T
Other languages
English (en)
Inventor
Werner Dr Skuballa
Bernd Dr Buchmann
Joseph Dr Heindl
Wolfgang Dr Froehlich
Roland Dr Ekerdt
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0399633T3 publication Critical patent/DK0399633T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/12Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0058Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a not condensed ring different from a five-membered ring
    • C07C405/0066Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a not condensed ring different from a five-membered ring to a six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK90250136.0T 1989-05-26 1990-05-25 Leukotrien B4-derivater, fremgangsmåde til fremstilling heraf samt deres anvendelse som lægemiddel DK0399633T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3917597A DE3917597A1 (de) 1989-05-26 1989-05-26 Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DK0399633T3 true DK0399633T3 (da) 1995-05-15

Family

ID=6381687

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90250136.0T DK0399633T3 (da) 1989-05-26 1990-05-25 Leukotrien B4-derivater, fremgangsmåde til fremstilling heraf samt deres anvendelse som lægemiddel

Country Status (15)

Country Link
US (1) US5187286A (da)
EP (1) EP0399633B1 (da)
JP (1) JP2921600B2 (da)
AT (1) ATE114633T1 (da)
AU (1) AU5669990A (da)
CA (1) CA2033187A1 (da)
DD (1) DD294705A5 (da)
DE (2) DE3917597A1 (da)
DK (1) DK0399633T3 (da)
ES (1) ES2065475T3 (da)
FI (1) FI910346A0 (da)
GR (1) GR3015097T3 (da)
HU (1) HUT55745A (da)
NO (1) NO910304L (da)
WO (1) WO1990014329A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4108351A1 (de) * 1991-03-12 1992-09-17 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5414016A (en) * 1991-03-12 1995-05-09 Schering Aktiengesellschaft New leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents
TW282463B (da) * 1991-11-15 1996-08-01 Sterling Winthrop Inc
EP0614457B1 (de) * 1991-11-29 1996-08-21 Schering Aktiengesellschaft Leukotrien-b 4?-derivative, verfahren zu ihrer herstellung und arzneimittel
AU5971394A (en) * 1994-01-27 1995-08-15 Schering Aktiengesellschaft Leukotriene b4 derivatives, methods of preparing them and their use as drugs
US5783602A (en) * 1994-01-27 1998-07-21 Schering Aktiengesellschaft Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents
CN1049992C (zh) * 1994-09-16 2000-03-01 联华电子股份有限公司 用于图像合成装置的位置转换装置
DE19722853A1 (de) * 1997-05-23 1998-12-10 Schering Ag Leukotrien-B¶4¶-Antagonisten, insbesondere 3-Carba-Tetrahydronaphthalin-LTB¶4¶-Antagonisten
DE19722845A1 (de) * 1997-05-23 1998-12-10 Schering Ag Leukotrien-B¶4¶-Derivate, insbesondere Interphenylen-7-Methylcyclohexyl-LTB¶4¶-Antagonisten
DE19722846A1 (de) * 1997-05-23 1998-12-24 Schering Ag Leukotrien-B¶4¶-Derivate, insbesondere 7-Methylcyclohexyl-LTB¶4¶-Antagonisten
US8729108B2 (en) * 2008-06-17 2014-05-20 Christopher J Dannaker Waterborne topical compositions for the delivery of active ingredients such as azelaic acid
WO2010039531A1 (en) * 2008-09-23 2010-04-08 Resolvyx Pharmaceuticals, Inc. Therapeutic compounds

Also Published As

Publication number Publication date
WO1990014329A1 (de) 1990-11-29
HU905269D0 (en) 1991-05-28
CA2033187A1 (en) 1990-11-27
JP2921600B2 (ja) 1999-07-19
AU5669990A (en) 1990-12-18
NO910304D0 (no) 1991-01-25
NO910304L (no) 1991-03-22
ATE114633T1 (de) 1994-12-15
DD294705A5 (de) 1991-10-10
JPH04501119A (ja) 1992-02-27
FI910346A7 (fi) 1991-01-23
DE59007805D1 (de) 1995-01-12
EP0399633B1 (de) 1994-11-30
ES2065475T3 (es) 1995-02-16
DE3917597A1 (de) 1990-11-29
US5187286A (en) 1993-02-16
GR3015097T3 (en) 1995-05-31
HUT55745A (en) 1991-06-28
FI910346A0 (fi) 1991-01-23
EP0399633A1 (de) 1990-11-28

Similar Documents

Publication Publication Date Title
DK0399633T3 (da) Leukotrien B4-derivater, fremgangsmåde til fremstilling heraf samt deres anvendelse som lægemiddel
NO964813D0 (no) Fremgangsmåte for stabilisering av duocarmycinderivater
DE3561199D1 (en) Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient
SE7909392L (sv) Nya substituerade 5-(2-imidazolin-2-yl)-aminopyrimidiner
RU94030476A (ru) Производные пиперазина, способ их получения и фармацевтическая композиция
NO301542B1 (no) Nye pyrazin-derivater
KR890005086A (ko) 1-[(2- 피리미디닐) 아미노알킬]피페리딘, 그의 제법 및 치료에의 이용
DK0474712T3 (da) Anvendelse af lysolecitinderivater til fremstilling af et farmaceutisk præparat
DK118083D0 (da) Theophyllinylalkyloxadiazoler eller additionssalte deraf, deres fremstilling og anvendelse som laegemidler
IL63782A (en) 2-(1,4-benzodioxan-2-ylalkyl)imidazoles,their preparation and pharmaceutical compositions containing them
DK326481A (da) Fremgangsmaade til fremstilling af i 5-stillingen substituerede 5,10-dihydro-11h-dibenzo (b,e) (1,4) diazepin-11-oner eller syreadditionssalte deraf
DE58907920D1 (de) Neue Alkanophenone.
DK0419610T3 (da) Leukotrien-B4-derivater og fremgangsmåde til fremstilling deraf
KR890013033A (ko) 염기성-치환된 5-할로-티에노이소티아졸-3(2h)-온 1,1-디옥사이드, 이의 제조방법, 및 이를 함유하는 약제학적 제제
DE69130266D1 (de) Optisch wirksame Alkylendioxybenzolderivate und ihre Verwendung als Arzneimittel
DE59206593D1 (de) Verwendung von 2-Iminothiazolidin-4-onderivaten als neuartige Arzneimittelwirkstoffe
ES486049A1 (es) Procedimiento para la obtencion de derivados aminopropanoli-cos de la 6-hidroxi-2,3,4,5-tetrahidro-1h-1-benzazepin-2-ona
KR890002079A (ko) 1-[2-(페닐메틸)페닐]피페라진 및 그의 제조방법
DK0416069T3 (da) Leukotrien-B4derivater og fremgangsmåde til fremstilling deraf
DK0530268T3 (da) Fremgangsmåde til fremstilling af 7alfa-alkoxycephemderivater
JPS5551081A (en) Trans-3,4-epoxythujane and its preparation
SE8301785L (sv) Sett att framstella 2-tiofen-ettiksyraderivat och mellanprodukter erforderliga for deras framstellning
ES391916A1 (es) Un procedimiento de preparar nuevos compuestos de sulfoni- lurea o de sus sales.
JPS5566577A (en) Novel carboxylic derivative and its preparation
ATE1606T1 (de) Indanyloxaminsaeure-derivate, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.