DK0416286T3 - Sulfonylhydraziner og deres anvendelse som antineoplastiske midler og som antitrypanosomale midler - Google Patents

Sulfonylhydraziner og deres anvendelse som antineoplastiske midler og som antitrypanosomale midler

Info

Publication number: DK0416286T3
Authority: DK; Denmark
Prior art keywords: agents; sulfonylhydrazines; antitrypanosomal; aryl; alkyl
Prior art date: 1989-09-06

Application number

DK90114747.0T

Other languages

English (en)

Inventor

Alan C Sartorelli

Alan A Divo

Krishnamurthy Shyam

Philip G Penketh

Original Assignee

Univ Yale

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-06

Filing date

1990-08-01

Publication date

1995-12-11

1990-08-01 Application filed by Univ Yale filed Critical Univ Yale

1995-12-11 Application granted granted Critical

1995-12-11 Publication of DK0416286T3 publication Critical patent/DK0416286T3/da

Links

ISNKSXRJJVWFIL-UHFFFAOYSA-N (sulfonylamino)amine Chemical class NN=S(=O)=O ISNKSXRJJVWFIL-UHFFFAOYSA-N 0.000 title abstract 3
239000002246 antineoplastic agent Substances 0.000 title abstract 2
239000003702 antitrypanosomal agent Substances 0.000 title abstract 2
229940034982 antineoplastic agent Drugs 0.000 title 1
229940124578 antitrypanosomal agent Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
239000003795 chemical substances by application Substances 0.000 abstract 2
230000001035 methylating effect Effects 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
230000001099 anti-trypanosomal effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK90114747.0T 1989-09-06 1990-08-01 Sulfonylhydraziner og deres anvendelse som antineoplastiske midler og som antitrypanosomale midler DK0416286T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/403,533 US5101072A (en)	1989-09-06	1989-09-06	Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents

Publications (1)

Publication Number	Publication Date
DK0416286T3 true DK0416286T3 (da)	1995-12-11

Family

ID=23596136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90114747.0T DK0416286T3 (da)	1989-09-06	1990-08-01	Sulfonylhydraziner og deres anvendelse som antineoplastiske midler og som antitrypanosomale midler

Country Status (9)

Country	Link
US (1)	US5101072A (da)
EP (1)	EP0416286B1 (da)
JP (1)	JPH03167168A (da)
AT (1)	ATE126209T1 (da)
CA (1)	CA2024523A1 (da)
DE (1)	DE69021466T2 (da)
DK (1)	DK0416286T3 (da)
ES (1)	ES2076998T3 (da)
GR (1)	GR3018021T3 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5256820A (en) *	1991-11-08	1993-10-26	Yale University	1-alkyl-2-acyl-1,2-disulfonylhydrazines
US5637619A (en) *	1995-07-05	1997-06-10	Yale University	Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines
US6040338A (en) *	1997-11-03	2000-03-21	Yale University	N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents
US20020142941A1 (en) *	2001-03-30	2002-10-03	Pro Duct Health, Inc.	Intraductal treatment targeting methylated promoters in breast cancer
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
US6855695B2 (en) *	2003-06-13	2005-02-15	Vion Pharmaceuticals, Inc.	Water-soluble SHPs as novel alkylating agents
WO2005094282A2 (en) *	2004-03-26	2005-10-13	Vion Pharmaceuticals, Inc.	Combination therapy comprising cloretazinetm
JP4814245B2 (ja) *	2004-09-21	2011-11-16	ヴァイオンファーマシューティカルズ、インコーポレーテッド	低酸素選択性抗腫瘍剤としてのスルホニルヒドラジンのリン酸含有プロドラッグ
CA2789262C (en)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Pharma-informatics system
EP1808173A1 (en) *	2006-01-12	2007-07-18	Matthias Dormeyer	Use of CNS penetrating anticancer compounds for the treatment of protozan diseases
EP2063905B1 (en)	2006-09-18	2014-07-30	Raptor Pharmaceutical Inc	Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
TR201908314T4 (tr)	2009-02-20	2019-06-21	2 Bbb Medicines B V	Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1069637B (de) *		1960-04-28	Farbenfabriken Bayer Aktiengesellschaft Leverkusen Bayerwerk	Verfahren zur Herstellung von Hydraziden aliphatischer Sulfosäuren
US4209632A (en) *	1974-06-05	1980-06-24	Uniroyal, Inc.	Sulfonyl carbazates
US4175200A (en) *	1975-04-11	1979-11-20	Uniroyal, Inc.	N,N-Disubstituted sulfonyl hydrazines
US4684747A (en) *	1984-12-20	1987-08-04	Yale University	N,N'-bis(sulfonyl)hydrazines having antineoplastic activity
US4849563A (en) *	1986-01-21	1989-07-18	Yale University	Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity

1989
- 1989-09-06 US US07/403,533 patent/US5101072A/en not_active Expired - Lifetime
1990
- 1990-08-01 DK DK90114747.0T patent/DK0416286T3/da active
- 1990-08-01 ES ES90114747T patent/ES2076998T3/es not_active Expired - Lifetime
- 1990-08-01 DE DE69021466T patent/DE69021466T2/de not_active Expired - Fee Related
- 1990-08-01 AT AT90114747T patent/ATE126209T1/de not_active IP Right Cessation
- 1990-08-01 EP EP90114747A patent/EP0416286B1/en not_active Expired - Lifetime
- 1990-08-27 JP JP2222674A patent/JPH03167168A/ja active Pending
- 1990-09-04 CA CA002024523A patent/CA2024523A1/en not_active Abandoned
1995
- 1995-11-08 GR GR950403134T patent/GR3018021T3/el unknown

Also Published As

Publication number	Publication date
JPH03167168A (ja)	1991-07-19
ATE126209T1 (de)	1995-08-15
DE69021466D1 (de)	1995-09-14
US5101072A (en)	1992-03-31
ES2076998T3 (es)	1995-11-16
EP0416286A1 (en)	1991-03-13
EP0416286B1 (en)	1995-08-09
GR3018021T3 (en)	1996-02-29
DE69021466T2 (de)	1996-02-29
CA2024523A1 (en)	1991-03-07

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