GR3018021T3 - Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents. - Google Patents

Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents.

Info

Publication number: GR3018021T3
Authority: GR; Greece
Prior art keywords: agents; sulfonylhydrazines; antitrypanosomal; aryl; alkyl
Prior art date: 1989-09-06

Application number

GR950403134T

Other languages

English (en)

Inventor

Alan C Sartorelli

Alan A Divo

Krishnamurthy Shyam

Philip G Penketh

Original Assignee

Univ Yale

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-06

Filing date

1995-11-08

Publication date

1996-02-29

1995-11-08 Application filed by Univ Yale filed Critical Univ Yale

1996-02-29 Publication of GR3018021T3 publication Critical patent/GR3018021T3/el

Links

ISNKSXRJJVWFIL-UHFFFAOYSA-N (sulfonylamino)amine Chemical class NN=S(=O)=O ISNKSXRJJVWFIL-UHFFFAOYSA-N 0.000 title abstract 3
239000002246 antineoplastic agent Substances 0.000 title abstract 2
239000003702 antitrypanosomal agent Substances 0.000 title abstract 2
229940034982 antineoplastic agent Drugs 0.000 title 1
229940124578 antitrypanosomal agent Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
239000003795 chemical substances by application Substances 0.000 abstract 2
230000001035 methylating effect Effects 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
230000001099 anti-trypanosomal effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

GR950403134T 1989-09-06 1995-11-08 Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents. GR3018021T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/403,533 US5101072A (en)	1989-09-06	1989-09-06	Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents

Publications (1)

Publication Number	Publication Date
GR3018021T3 true GR3018021T3 (en)	1996-02-29

Family

ID=23596136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR950403134T GR3018021T3 (en)	1989-09-06	1995-11-08	Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents.

Country Status (9)

Country	Link
US (1)	US5101072A (el)
EP (1)	EP0416286B1 (el)
JP (1)	JPH03167168A (el)
AT (1)	ATE126209T1 (el)
CA (1)	CA2024523A1 (el)
DE (1)	DE69021466T2 (el)
DK (1)	DK0416286T3 (el)
ES (1)	ES2076998T3 (el)
GR (1)	GR3018021T3 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5256820A (en) *	1991-11-08	1993-10-26	Yale University	1-alkyl-2-acyl-1,2-disulfonylhydrazines
US5637619A (en) *	1995-07-05	1997-06-10	Yale University	Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines
US6040338A (en) *	1997-11-03	2000-03-21	Yale University	N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents
US20020142941A1 (en) *	2001-03-30	2002-10-03	Pro Duct Health, Inc.	Intraductal treatment targeting methylated promoters in breast cancer
CA2450073C (en)	2001-07-25	2017-08-29	Biomarin Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
US6855695B2 (en) *	2003-06-13	2005-02-15	Vion Pharmaceuticals, Inc.	Water-soluble SHPs as novel alkylating agents
EP1804816B1 (en) *	2004-03-26	2011-12-21	Vion Pharmaceuticals, Inc.	Combination therapy comprising cloretazine(tm)
EP1793823B1 (en) *	2004-09-21	2012-08-08	Vion Pharmaceuticals, Inc.	Phosphate containing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents
EP2671508B1 (en)	2005-04-28	2020-09-16	Proteus Digital Health, Inc.	Pharma-informatics system
EP1808173A1 (en) *	2006-01-12	2007-07-18	Matthias Dormeyer	Use of CNS penetrating anticancer compounds for the treatment of protozan diseases
JP2010503710A (ja)	2006-09-18	2010-02-04	ラプトールファーマシューティカルインコーポレイテッド	受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es)	2009-02-20	2022-07-27	Enhanx Biopharm Inc	Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko)	2009-05-06	2018-10-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1069637B (de) *		1960-04-28	Farbenfabriken Bayer Aktiengesellschaft Leverkusen Bayerwerk	Verfahren zur Herstellung von Hydraziden aliphatischer Sulfosäuren
US4209632A (en) *	1974-06-05	1980-06-24	Uniroyal, Inc.	Sulfonyl carbazates
US4175200A (en) *	1975-04-11	1979-11-20	Uniroyal, Inc.	N,N-Disubstituted sulfonyl hydrazines
US4684747A (en) *	1984-12-20	1987-08-04	Yale University	N,N'-bis(sulfonyl)hydrazines having antineoplastic activity
US4849563A (en) *	1986-01-21	1989-07-18	Yale University	Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity

1989
- 1989-09-06 US US07/403,533 patent/US5101072A/en not_active Expired - Lifetime
1990
- 1990-08-01 ES ES90114747T patent/ES2076998T3/es not_active Expired - Lifetime
- 1990-08-01 DE DE69021466T patent/DE69021466T2/de not_active Expired - Fee Related
- 1990-08-01 DK DK90114747.0T patent/DK0416286T3/da active
- 1990-08-01 EP EP90114747A patent/EP0416286B1/en not_active Expired - Lifetime
- 1990-08-01 AT AT90114747T patent/ATE126209T1/de not_active IP Right Cessation
- 1990-08-27 JP JP2222674A patent/JPH03167168A/ja active Pending
- 1990-09-04 CA CA002024523A patent/CA2024523A1/en not_active Abandoned
1995
- 1995-11-08 GR GR950403134T patent/GR3018021T3/el unknown

Also Published As

Publication number	Publication date
EP0416286B1 (en)	1995-08-09
DE69021466T2 (de)	1996-02-29
CA2024523A1 (en)	1991-03-07
DK0416286T3 (da)	1995-12-11
EP0416286A1 (en)	1991-03-13
US5101072A (en)	1992-03-31
JPH03167168A (ja)	1991-07-19
ES2076998T3 (es)	1995-11-16
ATE126209T1 (de)	1995-08-15
DE69021466D1 (de)	1995-09-14

Publication	Publication Date	Title
DK0416286T3 (da)	1995-12-11	Sulfonylhydraziner og deres anvendelse som antineoplastiske midler og som antitrypanosomale midler
SG54203A1 (en)	1998-11-16	Novel 7- (substituted)-8-(substituted)-9- [(substituted glycyl]-6-demethyl-6-deoxytetracyclines
FI902386A0 (fi)	1990-05-14	Nukleosidanaloger.
DK0582788T3 (da)	1999-02-01	7-(Substituerede)-9-[(substitueret glycyl)-amido]-demethyl-6-deoxytetracycliner
ATE184789T1 (de)	1999-10-15	Verwendung von carnosolsäure wegen seiner anticarcinogenen und antiviralen eigenschaften
ATE152111T1 (de)	1997-05-15	K-252a derivate
FI930977A0 (fi)	1993-03-04	Taxanderivat, deras framstaellning och onkologiska anvaendning
FI924118A0 (fi)	1992-09-15	Kinoxalinfoereningar och deras framstaellning och anvaendning.
ZA918703B (en)	1992-07-29	Fungicidal compositions
ES8205214A1 (es)	1982-06-01	Un procedimiento para la preparacion de un derivado de 3-o- desmetilsannamicina c o del antibiotico ax-127b-1.
GB2055377B (en)	1983-07-06	Cis-platinum (11) amine ascorbate complexes
AU6136690A (en)	1991-10-03	Triazinic compounds
AU580646B2 (en)	1989-01-19	13``-alkyl-17``-(3-aceloxy-propyl)-gonane
HUT37646A (en)	1986-01-23	Fireproof, biologically degradable working liquid
SE8100341L (sv)	1981-07-25	Antitumormedel och kompositioner pa basis derav samt forfarande for framstellning av dessa kompositioner
DE3660426D1 (de)	1988-09-01	Urea acryl derivatives
DK0610076T3 (da)	1999-01-25	Cytotoksiske forbindelser
ZA877951B (en)	1988-04-26	Acylation products of bis(2-imidazolin-2-ylhydrazones)of 9,10-anthracenedicarboxaldehyde
IT1245737B (it)	1994-10-14	Trialchilsilil tetrafluoroetanfosfonati e procedimento per la loro preparazione
FR2508909B1 (el)	1983-12-23
JPS5390247A (en)	1978-08-08	2-methylene-4-oxycyclopentanone derivs. and process for their preparation