DK0417449T3 - Arylpyrazolderivater som blodpladeaggregationsinhibitorer - Google Patents

Arylpyrazolderivater som blodpladeaggregationsinhibitorer

Info

Publication number: DK0417449T3
Authority: DK; Denmark
Prior art keywords: hydrogen; platelet aggregation; integer; aggregation inhibitors; inhibitors
Prior art date: 1989-07-31

Application number

DK90114619.1T

Other languages

English (en)

Inventor

Nicholas Andrew Meanwell

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-31

Filing date

1990-07-30

Publication date

1995-04-03

1990-07-30 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1995-04-03 Application granted granted Critical

1995-04-03 Publication of DK0417449T3 publication Critical patent/DK0417449T3/da

Links

229940127218 antiplatelet drug Drugs 0.000 title 1
239000000106 platelet aggregation inhibitor Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
239000003112 inhibitor Substances 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 abstract 1
XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 abstract 1
102000008186 Collagen Human genes 0.000 abstract 1
108010035532 Collagen Proteins 0.000 abstract 1
230000002776 aggregation Effects 0.000 abstract 1
238000004220 aggregation Methods 0.000 abstract 1
210000001772 blood platelet Anatomy 0.000 abstract 1
229920001436 collagen Polymers 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
210000004623 platelet-rich plasma Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Separation Of Suspended Particles By Flocculating Agents (AREA)

DK90114619.1T 1989-07-31 1990-07-30 Arylpyrazolderivater som blodpladeaggregationsinhibitorer DK0417449T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38774989A	1989-07-31	1989-07-31
US07/523,637 US4994482A (en)	1989-07-31	1990-05-10	Arylpyrazol derivatives as anti-platelet agents, compositions and use

Publications (1)

Publication Number	Publication Date
DK0417449T3 true DK0417449T3 (da)	1995-04-03

Family

ID=27012007

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90114619.1T DK0417449T3 (da)	1989-07-31	1990-07-30	Arylpyrazolderivater som blodpladeaggregationsinhibitorer

Country Status (13)

Country	Link
US (1)	US4994482A (da)
EP (1)	EP0417449B1 (da)
JP (1)	JP2939909B2 (da)
AT (1)	ATE118485T1 (da)
AU (1)	AU630991B2 (da)
CA (1)	CA2022183C (da)
DE (1)	DE69016894T2 (da)
DK (1)	DK0417449T3 (da)
ES (1)	ES2067601T3 (da)
FI (1)	FI104169B (da)
GR (1)	GR3015206T3 (da)
IE (1)	IE66600B1 (da)
PT (1)	PT94856B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5374712A (en) *	1989-12-20	1994-12-20	Case Western Reserve University	Imidazopyridinium compound and processes for isolating, identifying, and chemically synthesizing same
US5155126A (en) *	1990-03-20	1992-10-13	E. I. Du Pont De Nemours And Company	Treatment of central nervous system disorders with pyrazole, pyrrole and triazole angiotensin-II receptor antagonists
DE4330959A1 (de) *	1993-09-09	1995-03-16	Schering Ag	Neue Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
DE19649460A1 (de) *	1996-11-26	1998-05-28	Bayer Ag	Neue substituierte Pyrazolderivate
DE19904391A1 (de) *	1999-02-04	2000-08-10	Bayer Ag	Pyrazol-Alkylamide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ178996A (en) *	1974-11-15	1978-06-02	Kornis G	Pyrfazole amides and thioamides;herbicidal compositions
CA1098527A (en) *	1976-12-20	1981-03-31	Denis M. Bailey	1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles
DE3228271A1 (de) *	1982-07-29	1984-02-02	A. Nattermann & Cie GmbH, 5000 Köln	Triphenylimidazolyloxyalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4826868A (en) *	1986-05-29	1989-05-02	Ortho Pharmaceutical Corporation	1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
IL86926A (en) *	1987-07-13	1992-07-15	Sterling Drug Inc	Diphenyl-1h-pyrazole-1-alkanamides,their preparation and antiarrhythmic compositions containing them
US4916150A (en) *	1989-03-22	1990-04-10	Sterling Drug Inc.	1H-pyrazole-1-alkanamines antiarrhythmic compositions and use
US4898880A (en) *	1989-03-22	1990-02-06	Sterling Drug Inc.	N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use

1990
- 1990-05-10 US US07/523,637 patent/US4994482A/en not_active Expired - Lifetime
- 1990-07-26 FI FI903741A patent/FI104169B/fi active IP Right Grant
- 1990-07-27 CA CA002022183A patent/CA2022183C/en not_active Expired - Fee Related
- 1990-07-30 PT PT94856A patent/PT94856B/pt not_active IP Right Cessation
- 1990-07-30 DE DE69016894T patent/DE69016894T2/de not_active Expired - Fee Related
- 1990-07-30 DK DK90114619.1T patent/DK0417449T3/da active
- 1990-07-30 AU AU59970/90A patent/AU630991B2/en not_active Ceased
- 1990-07-30 AT AT90114619T patent/ATE118485T1/de not_active IP Right Cessation
- 1990-07-30 EP EP90114619A patent/EP0417449B1/en not_active Expired - Lifetime
- 1990-07-30 ES ES90114619T patent/ES2067601T3/es not_active Expired - Lifetime
- 1990-07-30 IE IE275790A patent/IE66600B1/en not_active IP Right Cessation
- 1990-07-30 JP JP2199359A patent/JP2939909B2/ja not_active Expired - Fee Related
1995
- 1995-02-28 GR GR940403971T patent/GR3015206T3/el unknown

Also Published As

Publication number	Publication date
US4994482A (en)	1991-02-19
AU5997090A (en)	1991-01-31
FI104169B1 (fi)	1999-11-30
PT94856A (pt)	1991-03-20
ATE118485T1 (de)	1995-03-15
JP2939909B2 (ja)	1999-08-25
PT94856B (pt)	1997-03-31
DE69016894D1 (de)	1995-03-23
IE66600B1 (en)	1996-01-24
CA2022183C (en)	2000-07-18
FI104169B (fi)	1999-11-30
IE902757A1 (en)	1991-02-27
CA2022183A1 (en)	1991-02-01
DE69016894T2 (de)	1995-06-08
AU630991B2 (en)	1992-11-12
ES2067601T3 (es)	1995-04-01
EP0417449A1 (en)	1991-03-20
FI903741A0 (fi)	1990-07-26
GR3015206T3 (en)	1995-05-31
JPH0381265A (ja)	1991-04-05
EP0417449B1 (en)	1995-02-15

Publication	Publication Date	Title
DK0378518T3 (da)	1994-10-24	Adenosinderivater med farmaceutisk aktivitet som antihypertensiva
ES2172580T3 (es)	2002-10-01	1,3-oxatiolanos sustituidos con propiedades antiviricas.
DE3781716D1 (de)	1992-10-22	Mittel zur ortsspezifischen alkylierung.
DE68924681D1 (de)	1995-12-07	Heterocyclische Biphosphonsäurederivate.
FI862757A0 (fi)	1986-06-27	Pyridonkarbonsyraderivat och foerfarande foer framstaellning av dessa.
FI915970A0 (fi)	1991-12-18	Laekemedel, som aer nyttiga vid vaord av cancer och som har antihistaminegenskaper.
GB8627512D0 (en)	1986-12-17	Phenoxyalkylcarboxylic acids & esters
AP9701010A0 (en)	1997-07-31	Piperidineacetic acid derivatives useful as fibrinogen.
DE3677943D1 (de)	1991-04-11	Zytoprotektive derivate zur anwendung bei ischaemischen erkrankungen, ihre herstellung und sie enthaltende zusammensetzungen.
DK0417449T3 (da)	1995-04-03	Arylpyrazolderivater som blodpladeaggregationsinhibitorer
ES8503333A1 (es)	1985-02-16	Un metodo de preparar derivados de 4-quinolona
FI890293A0 (fi)	1989-01-19	Foerfarande foer framstaellning av tioformamidderivat.
AU8672582A (en)	1983-02-10	Benzodioxane substituted imidazolines
MY102275A (en)	1992-05-15	Antimykotische aminoazole ii
DE69219219D1 (de)	1997-05-28	Verwendung von 3-Pyridazinone zur Verringerung der Blutplätchenzahl
EA200000598A1 (ru)	2001-02-26	Новые ингибиторы металлопротеазы, способ их получения и содержащие их фармацевтические композиции
ES8802507A1 (es)	1988-07-16	Procedimiento para preparar eteres 1,3-dioxano.
ATE99306T1 (de)	1994-01-15	Antagonisten von leukotrien d4.
ATE67197T1 (de)	1991-09-15	Thiadiazinon-derivate.